Project acronym 4DPHOTON
Project Beyond Light Imaging: High-Rate Single-Photon Detection in Four Dimensions
Researcher (PI) Massimiliano FIORINI
Host Institution (HI) ISTITUTO NAZIONALE DI FISICA NUCLEARE
Call Details Consolidator Grant (CoG), PE2, ERC-2018-COG
Summary Goal of the 4DPHOTON project is the development and construction of a photon imaging detector with unprecedented performance. The proposed device will be capable of detecting fluxes of single-photons up to one billion photons per second, over areas of several square centimetres, and will measure - for each photon - position and time simultaneously with resolutions better than ten microns and few tens of picoseconds, respectively. These figures of merit will open many important applications allowing significant advances in particle physics, life sciences or other emerging fields where excellent timing and position resolutions are simultaneously required.
Our goal will be achieved thanks to the use of an application-specific integrated circuit in 65 nm complementary metal-oxide-semiconductor (CMOS) technology, that will deliver a timing resolution of few tens of picoseconds at the pixel level, over few hundred thousand individually-active pixel channels, allowing very high rates of photons to be detected, and the corresponding information digitized and transferred to a processing unit.
As a result of the 4DPHOTON project we will remove the constraints that many light imaging applications have due to the lack of precise single-photon information on four dimensions (4D): the three spatial coordinates and time simultaneously. In particular, we will prove the performance of this detector in the field of particle physics, performing the reconstruction of Cherenkov photon rings with a timing resolution of ten picoseconds. With its excellent granularity, timing resolution, rate capability and compactness, this detector will represent a new paradigm for the realisation of future Ring Imaging Cherenkov detectors, capable of achieving high efficiency particle identification in environments with very high particle multiplicities, exploiting time-association of the photon hits.
Summary
Goal of the 4DPHOTON project is the development and construction of a photon imaging detector with unprecedented performance. The proposed device will be capable of detecting fluxes of single-photons up to one billion photons per second, over areas of several square centimetres, and will measure - for each photon - position and time simultaneously with resolutions better than ten microns and few tens of picoseconds, respectively. These figures of merit will open many important applications allowing significant advances in particle physics, life sciences or other emerging fields where excellent timing and position resolutions are simultaneously required.
Our goal will be achieved thanks to the use of an application-specific integrated circuit in 65 nm complementary metal-oxide-semiconductor (CMOS) technology, that will deliver a timing resolution of few tens of picoseconds at the pixel level, over few hundred thousand individually-active pixel channels, allowing very high rates of photons to be detected, and the corresponding information digitized and transferred to a processing unit.
As a result of the 4DPHOTON project we will remove the constraints that many light imaging applications have due to the lack of precise single-photon information on four dimensions (4D): the three spatial coordinates and time simultaneously. In particular, we will prove the performance of this detector in the field of particle physics, performing the reconstruction of Cherenkov photon rings with a timing resolution of ten picoseconds. With its excellent granularity, timing resolution, rate capability and compactness, this detector will represent a new paradigm for the realisation of future Ring Imaging Cherenkov detectors, capable of achieving high efficiency particle identification in environments with very high particle multiplicities, exploiting time-association of the photon hits.
Max ERC Funding
1 975 000 €
Duration
Start date: 2019-12-01, End date: 2024-11-30
Project acronym AFRISCREENWORLDS
Project African Screen Worlds: Decolonising Film and Screen Studies
Researcher (PI) Lindiwe Dovey
Host Institution (HI) SCHOOL OF ORIENTAL AND AFRICAN STUDIES ROYAL CHARTER
Call Details Consolidator Grant (CoG), SH5, ERC-2018-COG
Summary A half century since it came into existence, the discipline of Film and Screen Studies remains mostly Eurocentric in its historical, theoretical and critical frameworks. Although “world cinema” and “transnational cinema” scholars have attempted to broaden its canon and frameworks, several major problems persist. Films and scholarship by Africans in particular, and by people of colour in general, are frequently marginalised if not altogether excluded. This prevents exciting exchanges that could help to re-envision Film and Screen Studies for the twenty-first century, in an era in which greater access to the technological means of making films, and circulating them on a range of screens, means that dynamic “screen worlds” are developing at a rapid rate. AFRISCREENWORLDS will study these “screen worlds” (in both their textual forms and industrial structures), with a focus on Africa, as a way of centring the most marginalised regional cinema. We will also elaborate comparative studies of global “screen worlds” – and, in particular, “screen worlds” in the Global South – exploring their similarities, differences, and parallel developments. We will respond to the exclusions of Film and Screen Studies not only in scholarly ways – through conferences and publications – but also in creative and activist ways – through drawing on cutting-edge creative research methodologies (such as audiovisual criticism and filmmaking) and through helping to decolonise Film and Screen Studies (through the production of ‘toolkits’ on how to make curricula, syllabi, and teaching more globally representative and inclusive). On a theoretical level, we will make an intervention through considering how the concept of “screen worlds” is better equipped than “world cinema” or “transnational cinema” to explore the complexities of audiovisual narratives, and their production and circulation in our contemporary moment, in diverse contexts throughout the globe.
Summary
A half century since it came into existence, the discipline of Film and Screen Studies remains mostly Eurocentric in its historical, theoretical and critical frameworks. Although “world cinema” and “transnational cinema” scholars have attempted to broaden its canon and frameworks, several major problems persist. Films and scholarship by Africans in particular, and by people of colour in general, are frequently marginalised if not altogether excluded. This prevents exciting exchanges that could help to re-envision Film and Screen Studies for the twenty-first century, in an era in which greater access to the technological means of making films, and circulating them on a range of screens, means that dynamic “screen worlds” are developing at a rapid rate. AFRISCREENWORLDS will study these “screen worlds” (in both their textual forms and industrial structures), with a focus on Africa, as a way of centring the most marginalised regional cinema. We will also elaborate comparative studies of global “screen worlds” – and, in particular, “screen worlds” in the Global South – exploring their similarities, differences, and parallel developments. We will respond to the exclusions of Film and Screen Studies not only in scholarly ways – through conferences and publications – but also in creative and activist ways – through drawing on cutting-edge creative research methodologies (such as audiovisual criticism and filmmaking) and through helping to decolonise Film and Screen Studies (through the production of ‘toolkits’ on how to make curricula, syllabi, and teaching more globally representative and inclusive). On a theoretical level, we will make an intervention through considering how the concept of “screen worlds” is better equipped than “world cinema” or “transnational cinema” to explore the complexities of audiovisual narratives, and their production and circulation in our contemporary moment, in diverse contexts throughout the globe.
Max ERC Funding
1 985 578 €
Duration
Start date: 2019-06-01, End date: 2024-05-31
Project acronym AMPHIBIANS
Project All Optical Manipulation of Photonic Metasurfaces for Biophotonic Applications in Microfluidic Environments
Researcher (PI) Andrea DI FALCO
Host Institution (HI) THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS
Call Details Consolidator Grant (CoG), PE7, ERC-2018-COG
Summary The current trend in biophotonics is to try and replicate the same ease and precision that our hands, eyes and ears offer at the macroscopic level, e.g. to hold, observe, squeeze and pull, rotate, cut and probe biological specimens in microfluidic environments. The bidding to get closer and closer to the object of interest has prompted the development of extremely advanced manipulation techniques at scales comparable to that of the wavelength of light. However, the fact that the optical beam can only access the microfluidic chip from the narrow aperture of a microscopic objective limits the versatility of the photonic function that can be realized.
With this project, the applicant proposes to introduce a new biophotonic platform based on the all optical manipulation of flexible photonic metasurfaces. These artificial two-dimensional materials have virtually arbitrary photonic responses and have an intrinsic exceptional mechanical stability. This cross-disciplinary project, bridging photonics, material sciences and biology, will enable the adoption of the most modern and advanced photonic designs in microfluidic environments, with transformative benefits for microscopy and biophotonic applications at the interface of molecular and cell biology.
Summary
The current trend in biophotonics is to try and replicate the same ease and precision that our hands, eyes and ears offer at the macroscopic level, e.g. to hold, observe, squeeze and pull, rotate, cut and probe biological specimens in microfluidic environments. The bidding to get closer and closer to the object of interest has prompted the development of extremely advanced manipulation techniques at scales comparable to that of the wavelength of light. However, the fact that the optical beam can only access the microfluidic chip from the narrow aperture of a microscopic objective limits the versatility of the photonic function that can be realized.
With this project, the applicant proposes to introduce a new biophotonic platform based on the all optical manipulation of flexible photonic metasurfaces. These artificial two-dimensional materials have virtually arbitrary photonic responses and have an intrinsic exceptional mechanical stability. This cross-disciplinary project, bridging photonics, material sciences and biology, will enable the adoption of the most modern and advanced photonic designs in microfluidic environments, with transformative benefits for microscopy and biophotonic applications at the interface of molecular and cell biology.
Max ERC Funding
1 999 524 €
Duration
Start date: 2019-02-01, End date: 2024-01-31
Project acronym APOLLO
Project Advanced Signal Processing Technologies for Wireless Powered Communications
Researcher (PI) Ioannis Krikidis
Host Institution (HI) UNIVERSITY OF CYPRUS
Call Details Consolidator Grant (CoG), PE7, ERC-2018-COG
Summary Wireless power transfer (WPT), pioneered by Tesla, is an idea at least as old as radio communications. However, on the one hand, due to health concerns and the large antenna dimensions required for transmission of high energy levels, until recently WPT has been limited mostly to very short distance applications. On the other hand, recent advances in silicon technology have significantly reduced the energy needs of electronic systems, making WPT over radio waves a potential source of energy for low power devices. Although WPT through radio waves has already found various short-range applications (such as the radio-frequency identification technology, healthcare monitoring etc.), its integration as a building block in the operation of wireless communications systems is still unexploited. On the other hand, conventional radio wave based information and energy transmissions have largely been designed separately. However, many applications can benefit from simultaneous wireless information and power transfer (SWIPT).
The overall objective of the APOLLO project is to study the integration of WPT/SWIPT technology into future wireless communication systems. Compared to past and current research efforts in this area, our technical approach is deeply interdisciplinary and more comprehensive, combining the expertise of wireless communications, control theory, information theory, optimization, and electronics/microwave engineering.
The key outcomes of the project include: 1) a rigorous and complete mathematical theory for WPT/SWIPT via information/communication/control theoretic studies; 2) new physical and cross-layer mechanisms that will enable the integration of WPT/SWIPT into future communication systems; 3) new network architectures that will fully exploit potential benefits of WPT/SWIPT; and 4) development of a proof-of-concept by implementing highly-efficient and multi-band metamaterial energy harvesting sensors for SWIPT.
Summary
Wireless power transfer (WPT), pioneered by Tesla, is an idea at least as old as radio communications. However, on the one hand, due to health concerns and the large antenna dimensions required for transmission of high energy levels, until recently WPT has been limited mostly to very short distance applications. On the other hand, recent advances in silicon technology have significantly reduced the energy needs of electronic systems, making WPT over radio waves a potential source of energy for low power devices. Although WPT through radio waves has already found various short-range applications (such as the radio-frequency identification technology, healthcare monitoring etc.), its integration as a building block in the operation of wireless communications systems is still unexploited. On the other hand, conventional radio wave based information and energy transmissions have largely been designed separately. However, many applications can benefit from simultaneous wireless information and power transfer (SWIPT).
The overall objective of the APOLLO project is to study the integration of WPT/SWIPT technology into future wireless communication systems. Compared to past and current research efforts in this area, our technical approach is deeply interdisciplinary and more comprehensive, combining the expertise of wireless communications, control theory, information theory, optimization, and electronics/microwave engineering.
The key outcomes of the project include: 1) a rigorous and complete mathematical theory for WPT/SWIPT via information/communication/control theoretic studies; 2) new physical and cross-layer mechanisms that will enable the integration of WPT/SWIPT into future communication systems; 3) new network architectures that will fully exploit potential benefits of WPT/SWIPT; and 4) development of a proof-of-concept by implementing highly-efficient and multi-band metamaterial energy harvesting sensors for SWIPT.
Max ERC Funding
1 930 625 €
Duration
Start date: 2019-07-01, End date: 2024-06-30
Project acronym Atto-Zepto
Project Ultrasensitive Nano-Optomechanical Sensors
Researcher (PI) Olivier ARCIZET
Host Institution (HI) CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Call Details Consolidator Grant (CoG), PE2, ERC-2018-COG
Summary By enabling the conversion of forces into measurable displacements, mechanical oscillators have always played a central role in experimental physics. Recent developments in the PI group demonstrated the possibility to realize ultrasensitive and vectorial force field sensing by using suspended SiC nanowires and optical readout of their transverse vibrations. Astonishing sensitivities were obtained at room and dilution temperatures, at the Atto- Zepto-newton level, for which the electron-electron interaction becomes detectable at 100µm.
The goal of the project is to push forward those ultrasensitive nano-optomechanical force sensors, to realize even more challenging explorations of novel fundamental interactions at the quantum-classical interface.
We will develop universal advanced sensing protocols to explore the vectorial structure of fundamental optical, electrostatic or magnetic interactions, and investigate Casimir force fields above nanostructured surfaces, in geometries where it was recently predicted to become repulsive. The second research axis is the one of cavity nano-optomechanics: inserting the ultrasensitive nanowire in a high finesse optical microcavity should enhance the light-nanowire interaction up to the point where a single cavity photon can displace the nanowire by more than its zero point quantum fluctuations. We will investigate this so-called ultrastrong optomechanical coupling regime, and further explore novel regimes in cavity optomechanics, where optical non-linearities at the single photon level become accessible. The last part is dedicated to the exploration of hybrid qubit-mechanical systems, in which nanowire vibrations are magnetically coupled to the spin of a single Nitrogen Vacancy defect in diamond. We will focus on the exploration of spin-dependent forces, aiming at mechanically detecting qubit excitations, opening a novel road towards the generation of non-classical states of motion, and mechanically enhanced quantum sensors.
Summary
By enabling the conversion of forces into measurable displacements, mechanical oscillators have always played a central role in experimental physics. Recent developments in the PI group demonstrated the possibility to realize ultrasensitive and vectorial force field sensing by using suspended SiC nanowires and optical readout of their transverse vibrations. Astonishing sensitivities were obtained at room and dilution temperatures, at the Atto- Zepto-newton level, for which the electron-electron interaction becomes detectable at 100µm.
The goal of the project is to push forward those ultrasensitive nano-optomechanical force sensors, to realize even more challenging explorations of novel fundamental interactions at the quantum-classical interface.
We will develop universal advanced sensing protocols to explore the vectorial structure of fundamental optical, electrostatic or magnetic interactions, and investigate Casimir force fields above nanostructured surfaces, in geometries where it was recently predicted to become repulsive. The second research axis is the one of cavity nano-optomechanics: inserting the ultrasensitive nanowire in a high finesse optical microcavity should enhance the light-nanowire interaction up to the point where a single cavity photon can displace the nanowire by more than its zero point quantum fluctuations. We will investigate this so-called ultrastrong optomechanical coupling regime, and further explore novel regimes in cavity optomechanics, where optical non-linearities at the single photon level become accessible. The last part is dedicated to the exploration of hybrid qubit-mechanical systems, in which nanowire vibrations are magnetically coupled to the spin of a single Nitrogen Vacancy defect in diamond. We will focus on the exploration of spin-dependent forces, aiming at mechanically detecting qubit excitations, opening a novel road towards the generation of non-classical states of motion, and mechanically enhanced quantum sensors.
Max ERC Funding
2 067 905 €
Duration
Start date: 2019-09-01, End date: 2024-08-31
Project acronym BrightEyes
Project Multi-Parameter Live-Cell Observation of Biomolecular Processes with Single-Photon Detector Array
Researcher (PI) Giuseppe Vicidomini
Host Institution (HI) FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
Call Details Consolidator Grant (CoG), PE7, ERC-2018-COG
Summary Fluorescence single-molecule (SM) detection techniques have the potential to provide insights into the complex functions, structures and interactions of individual, specifically labelled biomolecules. However, current SM techniques work properly only when the biomolecule is observed in controlled environments, e.g., immobilized on a glass surface. Observation of biomolecular processes in living (multi)cellular environments – which is fundamental for sound biological conclusion – always comes with a price, such as invasiveness, limitations in the accessible information and constraints in the spatial and temporal scales.
The overall objective of the BrightEyes project is to break the above limitations by creating a novel SM approach compatible with the state-of-the-art biomolecule-labelling protocols, able to track a biomolecule deep inside (multi)cellular environments – with temporal resolution in the microsecond scale, and with hundreds of micrometres tracking range – and simultaneously observe its structural changes, its nano- and micro-environments.
Specifically, by exploring a novel single-photon detectors array, the BrightEyes project will implement an optical system, able to continuously (i) track in real-time the biomolecule of interest from which to decode its dynamics and interactions; (ii) measure the nano-environment fluorescence spectroscopy properties, such as lifetime, photon-pair correlation and intensity, from which to extract the biochemical properties of the nano-environment, the structural properties of the biomolecule – via SM-FRET and anti-bunching – and the interactions of the biomolecule with other biomolecular species – via STED-FCS; (iii) visualize the sub-cellular structures within the micro-environment with sub-diffraction spatial resolution – via STED and image scanning microscopy.
This unique paradigm will enable unprecedented studies of biomolecular behaviours, interactions and self-organization at near-physiological conditions.
Summary
Fluorescence single-molecule (SM) detection techniques have the potential to provide insights into the complex functions, structures and interactions of individual, specifically labelled biomolecules. However, current SM techniques work properly only when the biomolecule is observed in controlled environments, e.g., immobilized on a glass surface. Observation of biomolecular processes in living (multi)cellular environments – which is fundamental for sound biological conclusion – always comes with a price, such as invasiveness, limitations in the accessible information and constraints in the spatial and temporal scales.
The overall objective of the BrightEyes project is to break the above limitations by creating a novel SM approach compatible with the state-of-the-art biomolecule-labelling protocols, able to track a biomolecule deep inside (multi)cellular environments – with temporal resolution in the microsecond scale, and with hundreds of micrometres tracking range – and simultaneously observe its structural changes, its nano- and micro-environments.
Specifically, by exploring a novel single-photon detectors array, the BrightEyes project will implement an optical system, able to continuously (i) track in real-time the biomolecule of interest from which to decode its dynamics and interactions; (ii) measure the nano-environment fluorescence spectroscopy properties, such as lifetime, photon-pair correlation and intensity, from which to extract the biochemical properties of the nano-environment, the structural properties of the biomolecule – via SM-FRET and anti-bunching – and the interactions of the biomolecule with other biomolecular species – via STED-FCS; (iii) visualize the sub-cellular structures within the micro-environment with sub-diffraction spatial resolution – via STED and image scanning microscopy.
This unique paradigm will enable unprecedented studies of biomolecular behaviours, interactions and self-organization at near-physiological conditions.
Max ERC Funding
1 861 250 €
Duration
Start date: 2019-09-01, End date: 2024-08-31
Project acronym CaLA
Project The Capillary Lock Actuator: A novel bistable microfluidic actuator for cost-effective high-density actuator arrays suitable for large-scale graphical tactile displays
Researcher (PI) Bastian Rapp
Host Institution (HI) ALBERT-LUDWIGS-UNIVERSITAET FREIBURG
Call Details Consolidator Grant (CoG), PE7, ERC-2018-COG
Summary According to the World Health Organization more than 285 million people worldwide are visually impaired. In a world where graphics and online content (images, webpages) become increasingly important the inability to perceive information visually is the primary inhibitor for inclusion. In contrast to display technology for sighted people, tactile displays which translate text and graphics to touchable pixels (taxels) have seen little progress in recent decades. So-called Braille lines which display only a single line of text are still the norm. The reason why graphical tactile displays do not exist is the lack of a suitable actuator technology which allows generating massively parallelized individually addressable cost-effective taxel arrays.
This ERC Consolidator project aims at a revolution in microactuator array technology with a fundamentally new concept termed the Capillary Lock Actuator (CaLA). CaLA is a novel bistable massively parallelizable microfluidic microactuator which overcomes many of the limitations currently associated with microactuators. It can be operated with low-voltage control signals and requires virtually no power for actuation. CaLA harnesses three concepts inherent to microfluidics: positive capillary pressure, segmented flow and controllable locally confined changes in wetting. The project will use CaLA actuator arrays for setting up the very first portable tactile graphic display with 30.000 individually addressable taxels thereby significantly outperforming the state-of-the-art. It will be based on manufacturing techniques for highly complex microstructures in glass invented by my group.
CaLA will be a significant breakthrough in actuator technology and enabling for many applications in microsystem technology. Most importantly, it will be a significant step towards making the information technology inclusive for the visually impaired by providing the first robust cost-effective solution to large-scale tactile displays.
Summary
According to the World Health Organization more than 285 million people worldwide are visually impaired. In a world where graphics and online content (images, webpages) become increasingly important the inability to perceive information visually is the primary inhibitor for inclusion. In contrast to display technology for sighted people, tactile displays which translate text and graphics to touchable pixels (taxels) have seen little progress in recent decades. So-called Braille lines which display only a single line of text are still the norm. The reason why graphical tactile displays do not exist is the lack of a suitable actuator technology which allows generating massively parallelized individually addressable cost-effective taxel arrays.
This ERC Consolidator project aims at a revolution in microactuator array technology with a fundamentally new concept termed the Capillary Lock Actuator (CaLA). CaLA is a novel bistable massively parallelizable microfluidic microactuator which overcomes many of the limitations currently associated with microactuators. It can be operated with low-voltage control signals and requires virtually no power for actuation. CaLA harnesses three concepts inherent to microfluidics: positive capillary pressure, segmented flow and controllable locally confined changes in wetting. The project will use CaLA actuator arrays for setting up the very first portable tactile graphic display with 30.000 individually addressable taxels thereby significantly outperforming the state-of-the-art. It will be based on manufacturing techniques for highly complex microstructures in glass invented by my group.
CaLA will be a significant breakthrough in actuator technology and enabling for many applications in microsystem technology. Most importantly, it will be a significant step towards making the information technology inclusive for the visually impaired by providing the first robust cost-effective solution to large-scale tactile displays.
Max ERC Funding
1 999 750 €
Duration
Start date: 2019-05-01, End date: 2024-04-30
Project acronym CHROMOTOPE
Project The 19th century chromatic turn - CHROMOTOPE
Researcher (PI) Charlotte Ribeyrol
Host Institution (HI) SORBONNE UNIVERSITE
Call Details Consolidator Grant (CoG), SH5, ERC-2018-COG
Summary CHROMOTOPE will offer the very first analysis of the changes that took place in attitudes to colour in the 19th century, and notably how the ‘chromatic turn’ of the 1850s mapped out new ways of thinking about colour in literature, art, science and technology throughout Europe. Britain’s industrial supremacy during this period is often perceived through the darkening filter of coal pollution, and yet the industrial revolution transformed colour thanks to a number of innovations like the invention in 1856 of the first aniline dye. Colour thus became a major signifier of the modern, generating new discourses on its production and perception. This Victorian ‘colour revolution’, which has never been approached from a cross-disciplinary perspective, came to prominence during the 1862 International Exhibition – a forgotten, and yet key, chromatic event which forced poets and artists like Ruskin, Morris and Burges to think anew about the materiality of colour. Rebelling against the bleakness of the industrial present, they invited their contemporaries to learn from the ‘sacred’ colours of the past – a ‘colour pedagogy’ which later shaped the European arts and crafts movement.
Building on a pioneering methodology, CHROMOTOPE will bring together literature, visual culture, the history of sciences and techniques and the chemistry of pigments and dyes, with high-impact outcomes, including one major exhibition at the Ashmolean Museum, a thorough pigment analysis of Burges’s Great Bookcase and the creation of an online database of 19th century texts on colour. This project will not only give invaluable insight into hitherto neglected aspects of 19th century European cultural history, it will also reveal the central role played by chromatic materiality in the intertwined artistic and literary practices of the period. This will in turn change the way the relationships between text and image, as well as the materiality of the text itself, may be envisaged in literary studies.
Summary
CHROMOTOPE will offer the very first analysis of the changes that took place in attitudes to colour in the 19th century, and notably how the ‘chromatic turn’ of the 1850s mapped out new ways of thinking about colour in literature, art, science and technology throughout Europe. Britain’s industrial supremacy during this period is often perceived through the darkening filter of coal pollution, and yet the industrial revolution transformed colour thanks to a number of innovations like the invention in 1856 of the first aniline dye. Colour thus became a major signifier of the modern, generating new discourses on its production and perception. This Victorian ‘colour revolution’, which has never been approached from a cross-disciplinary perspective, came to prominence during the 1862 International Exhibition – a forgotten, and yet key, chromatic event which forced poets and artists like Ruskin, Morris and Burges to think anew about the materiality of colour. Rebelling against the bleakness of the industrial present, they invited their contemporaries to learn from the ‘sacred’ colours of the past – a ‘colour pedagogy’ which later shaped the European arts and crafts movement.
Building on a pioneering methodology, CHROMOTOPE will bring together literature, visual culture, the history of sciences and techniques and the chemistry of pigments and dyes, with high-impact outcomes, including one major exhibition at the Ashmolean Museum, a thorough pigment analysis of Burges’s Great Bookcase and the creation of an online database of 19th century texts on colour. This project will not only give invaluable insight into hitherto neglected aspects of 19th century European cultural history, it will also reveal the central role played by chromatic materiality in the intertwined artistic and literary practices of the period. This will in turn change the way the relationships between text and image, as well as the materiality of the text itself, may be envisaged in literary studies.
Max ERC Funding
1 884 867 €
Duration
Start date: 2019-10-01, End date: 2024-09-30
Project acronym CiliaTubulinCode
Project Self-organization of the cilium: the role of the tubulin code
Researcher (PI) Gaia PIGINO
Host Institution (HI) MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Call Details Consolidator Grant (CoG), LS1, ERC-2018-COG
Summary This project aims at understanding of the role of the tubulin code for self-organization of complex microtubule based structures. Cilia turn out to be the ideal structures for the proposed research.
A cilium is a sophisticated cellular machine that self-organizes from many protein complexes. It plays motility, sensory, and signaling roles in most eukaryotic cells, and its malfunction causes pathologies. The assembly of the cilium requires intraflagellar transport (IFT), a specialized bidirectional motility process that is mediated by adaptor proteins and direction specific molecular motors. Work from my lab shows that anterograde and retrograde IFT make exclusive use of the B-tubules and A-tubules, respectively. This insight answered a long standing question and shows that functional differentiation of tubules exists and is important for IFT.
Tubulin post-translational modifications (PTMs) contribute to a tubulin code, making microtubules suitable for specific functions. Mutation of tubulin-PTM enzymes can have dramatic effects on cilia function and assembly. However, we do not understand of the role of tubulin-PTMs in cilia. Therefore, I propose to address the hypotheses that the tubulin code contributes to regulating bidirectional IFT motility, and more generally, that the tubulin code is a key player in structuring complex cellular assembly processes in space and time.
This proposal aims at (i) understanding if tubulin-PTMs are necessary and/or sufficient to regulate the bidirectionality of IFT (ii) examining how the tubulin code regulates the assembly of cilia and (iii) generating a high-resolution atlas of tubulin-PTMs and their respective enzymes.
We will combine advanced techniques encompassing state-of-the-art cryo-electron tomography, biochemical imaging, fluorescent microscopy, and in vitro assays to achieve molecular and structural understanding of the role of the tubulin code in the self-organization of cilia and of microtubule based cellular structures.
Summary
This project aims at understanding of the role of the tubulin code for self-organization of complex microtubule based structures. Cilia turn out to be the ideal structures for the proposed research.
A cilium is a sophisticated cellular machine that self-organizes from many protein complexes. It plays motility, sensory, and signaling roles in most eukaryotic cells, and its malfunction causes pathologies. The assembly of the cilium requires intraflagellar transport (IFT), a specialized bidirectional motility process that is mediated by adaptor proteins and direction specific molecular motors. Work from my lab shows that anterograde and retrograde IFT make exclusive use of the B-tubules and A-tubules, respectively. This insight answered a long standing question and shows that functional differentiation of tubules exists and is important for IFT.
Tubulin post-translational modifications (PTMs) contribute to a tubulin code, making microtubules suitable for specific functions. Mutation of tubulin-PTM enzymes can have dramatic effects on cilia function and assembly. However, we do not understand of the role of tubulin-PTMs in cilia. Therefore, I propose to address the hypotheses that the tubulin code contributes to regulating bidirectional IFT motility, and more generally, that the tubulin code is a key player in structuring complex cellular assembly processes in space and time.
This proposal aims at (i) understanding if tubulin-PTMs are necessary and/or sufficient to regulate the bidirectionality of IFT (ii) examining how the tubulin code regulates the assembly of cilia and (iii) generating a high-resolution atlas of tubulin-PTMs and their respective enzymes.
We will combine advanced techniques encompassing state-of-the-art cryo-electron tomography, biochemical imaging, fluorescent microscopy, and in vitro assays to achieve molecular and structural understanding of the role of the tubulin code in the self-organization of cilia and of microtubule based cellular structures.
Max ERC Funding
1 986 406 €
Duration
Start date: 2019-03-01, End date: 2024-02-29
Project acronym CLIC
Project Classical Influences and Irish Culture
Researcher (PI) Isabelle Torrance
Host Institution (HI) AARHUS UNIVERSITET
Call Details Consolidator Grant (CoG), SH5, ERC-2018-COG
Summary The hypothesis of this project is that Ireland has a unique and hitherto underexplored history of cultural engagement with models from ancient Greece and Rome. Unlike Britain and mainland Europe, Ireland was never part of the Roman Empire. Yet the island has an extraordinarily vibrant tradition of classical learning that dates back to its earliest recorded literature, and is unparalleled in other northern European countries. Research for this project will address why this is the case, by examining sources through nine significant diachronic themes identified by the PI: language; land; travel and exile; Troy; satire; Neoplatonism; female voices; material culture; and global influence. This multi-thematic approach will enable analysis of what is remarkable about classical reception in Ireland. It will also provide a heuristic framework that generates dialogue between normally disparate fields, such as classical reception studies, Irish and British history, English-language literature, Irish-language literature, medieval studies, postcolonial studies, philosophy, material culture, women's studies, and global studies. The project will engage with contemporary preoccupations surrounding the politics and history of the divided island of Ireland, such as the current decade of centenary commemorations for the foundation of an independent Irish state (1912-1922, 2012-2022), and the on-going violence and political divisions in Northern Ireland. These issues will serve as a springboard for opening new avenues of investigation that look far beyond the past 100 years, but are linked to them. The project will thus shed new light on the role of classical culture in shaping literary, social, and political discourse across the island of Ireland, and throughout its history.
Summary
The hypothesis of this project is that Ireland has a unique and hitherto underexplored history of cultural engagement with models from ancient Greece and Rome. Unlike Britain and mainland Europe, Ireland was never part of the Roman Empire. Yet the island has an extraordinarily vibrant tradition of classical learning that dates back to its earliest recorded literature, and is unparalleled in other northern European countries. Research for this project will address why this is the case, by examining sources through nine significant diachronic themes identified by the PI: language; land; travel and exile; Troy; satire; Neoplatonism; female voices; material culture; and global influence. This multi-thematic approach will enable analysis of what is remarkable about classical reception in Ireland. It will also provide a heuristic framework that generates dialogue between normally disparate fields, such as classical reception studies, Irish and British history, English-language literature, Irish-language literature, medieval studies, postcolonial studies, philosophy, material culture, women's studies, and global studies. The project will engage with contemporary preoccupations surrounding the politics and history of the divided island of Ireland, such as the current decade of centenary commemorations for the foundation of an independent Irish state (1912-1922, 2012-2022), and the on-going violence and political divisions in Northern Ireland. These issues will serve as a springboard for opening new avenues of investigation that look far beyond the past 100 years, but are linked to them. The project will thus shed new light on the role of classical culture in shaping literary, social, and political discourse across the island of Ireland, and throughout its history.
Max ERC Funding
1 888 592 €
Duration
Start date: 2019-10-01, End date: 2024-09-30
