Project acronym AXIAL.EC
Project PRINCIPLES OF AXIAL POLARITY-DRIVEN VASCULAR PATTERNING
Researcher (PI) Claudio Franco
Host Institution (HI) INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES
Call Details Starting Grant (StG), LS4, ERC-2015-STG
Summary The formation of a functional patterned vascular network is essential for development, tissue growth and organ physiology. Several human vascular disorders arise from the mis-patterning of blood vessels, such as arteriovenous malformations, aneurysms and diabetic retinopathy. Although blood flow is recognised as a stimulus for vascular patterning, very little is known about the molecular mechanisms that regulate endothelial cell behaviour in response to flow and promote vascular patterning.
Recently, we uncovered that endothelial cells migrate extensively in the immature vascular network, and that endothelial cells polarise against the blood flow direction. Here, we put forward the hypothesis that vascular patterning is dependent on the polarisation and migration of endothelial cells against the flow direction, in a continuous flux of cells going from low-shear stress to high-shear stress regions. We will establish new reporter mouse lines to observe and manipulate endothelial polarity in vivo in order to investigate how polarisation and coordination of endothelial cells movements are orchestrated to generate vascular patterning. We will manipulate cell polarity using mouse models to understand the importance of cell polarisation in vascular patterning. Also, using a unique zebrafish line allowing analysis of endothelial cell polarity, we will perform a screen to identify novel regulators of vascular patterning. Finally, we will explore the hypothesis that defective flow-dependent endothelial polarisation underlies arteriovenous malformations using two genetic models.
This integrative approach, based on high-resolution imaging and unique experimental models, will provide a unifying model defining the cellular and molecular principles involved in vascular patterning. Given the physiological relevance of vascular patterning in health and disease, this research plan will set the basis for the development of novel clinical therapies targeting vascular disorders.
Summary
The formation of a functional patterned vascular network is essential for development, tissue growth and organ physiology. Several human vascular disorders arise from the mis-patterning of blood vessels, such as arteriovenous malformations, aneurysms and diabetic retinopathy. Although blood flow is recognised as a stimulus for vascular patterning, very little is known about the molecular mechanisms that regulate endothelial cell behaviour in response to flow and promote vascular patterning.
Recently, we uncovered that endothelial cells migrate extensively in the immature vascular network, and that endothelial cells polarise against the blood flow direction. Here, we put forward the hypothesis that vascular patterning is dependent on the polarisation and migration of endothelial cells against the flow direction, in a continuous flux of cells going from low-shear stress to high-shear stress regions. We will establish new reporter mouse lines to observe and manipulate endothelial polarity in vivo in order to investigate how polarisation and coordination of endothelial cells movements are orchestrated to generate vascular patterning. We will manipulate cell polarity using mouse models to understand the importance of cell polarisation in vascular patterning. Also, using a unique zebrafish line allowing analysis of endothelial cell polarity, we will perform a screen to identify novel regulators of vascular patterning. Finally, we will explore the hypothesis that defective flow-dependent endothelial polarisation underlies arteriovenous malformations using two genetic models.
This integrative approach, based on high-resolution imaging and unique experimental models, will provide a unifying model defining the cellular and molecular principles involved in vascular patterning. Given the physiological relevance of vascular patterning in health and disease, this research plan will set the basis for the development of novel clinical therapies targeting vascular disorders.
Max ERC Funding
1 618 750 €
Duration
Start date: 2016-09-01, End date: 2021-08-31
Project acronym ContentMAP
Project Contentotopic mapping: the topographical organization of object knowledge in the brain
Researcher (PI) Jorge ALMEIDA
Host Institution (HI) UNIVERSIDADE DE COIMBRA
Call Details Starting Grant (StG), SH4, ERC-2018-STG
Summary Our ability to recognize an object amongst many others is one of the most important features of the human mind. However, object recognition requires tremendous computational effort, as we need to solve a complex and recursive environment with ease and proficiency. This challenging feat is dependent on the implementation of an effective organization of knowledge in the brain. In ContentMAP I will put forth a novel understanding of how object knowledge is organized in the brain, by proposing that this knowledge is topographically laid out in the cortical surface according to object-related dimensions that code for different types of representational content – I will call this contentotopic mapping. To study this fine-grain topography, I will use a combination of fMRI, behavioral, and neuromodulation approaches. I will first obtain patterns of neural and cognitive similarity between objects, and from these extract object-related dimensions using a dimensionality reduction technique. I will then parametrically manipulate these dimensions with an innovative use of a visual field mapping technique, and test how functional selectivity changes across the cortical surface according to an object’s score on a target dimension. Moreover, I will test the tuning function of these contentotopic maps. Finally, to mirror the complexity of implementing a high-dimensional manifold onto a 2D cortical sheet, I will aggregate the topographies for the different dimensions into a composite map, and develop an encoding model to predict neural signatures for each object. To sum up, ContentMAP will have a dramatic impact in the cognitive sciences by describing how the stuff of concepts is represented in the brain, and providing a complete description of how fine-grain representations and functional selectivity within high-level complex processes are topographically implemented.
Summary
Our ability to recognize an object amongst many others is one of the most important features of the human mind. However, object recognition requires tremendous computational effort, as we need to solve a complex and recursive environment with ease and proficiency. This challenging feat is dependent on the implementation of an effective organization of knowledge in the brain. In ContentMAP I will put forth a novel understanding of how object knowledge is organized in the brain, by proposing that this knowledge is topographically laid out in the cortical surface according to object-related dimensions that code for different types of representational content – I will call this contentotopic mapping. To study this fine-grain topography, I will use a combination of fMRI, behavioral, and neuromodulation approaches. I will first obtain patterns of neural and cognitive similarity between objects, and from these extract object-related dimensions using a dimensionality reduction technique. I will then parametrically manipulate these dimensions with an innovative use of a visual field mapping technique, and test how functional selectivity changes across the cortical surface according to an object’s score on a target dimension. Moreover, I will test the tuning function of these contentotopic maps. Finally, to mirror the complexity of implementing a high-dimensional manifold onto a 2D cortical sheet, I will aggregate the topographies for the different dimensions into a composite map, and develop an encoding model to predict neural signatures for each object. To sum up, ContentMAP will have a dramatic impact in the cognitive sciences by describing how the stuff of concepts is represented in the brain, and providing a complete description of how fine-grain representations and functional selectivity within high-level complex processes are topographically implemented.
Max ERC Funding
1 816 004 €
Duration
Start date: 2019-02-01, End date: 2024-01-31
Project acronym CRISP
Project Cognitive Aging: From Educational Opportunities to Individual Risk Profiles
Researcher (PI) Anja LEIST
Host Institution (HI) UNIVERSITE DU LUXEMBOURG
Call Details Starting Grant (StG), SH3, ERC-2018-STG
Summary Cognitive impairment and dementia have dramatic individual and social consequences, and create high economic costs for societies. In order to delay cognitive aging of future generations as long as possible, we need evidence about which contextual factors are most supportive for individuals to reach highest cognitive levels relative to their potential. At the same time, for current older generations, we need scalable methods to exactly identify individuals at risk of cognitive impairment. The project intends to apply recent methodological and statistical advancements to reach two objectives. Firstly, contextual influences on cognitive aging will be comparatively assessed, with a focus on inequalities related to educational opportunities and gender inequalities. This will be done using longitudinal, population-representative, harmonized cross-national aging surveys, merged with contextual information. Secondly, the project will quantify the ability of singular and clustered individual characteristics, such as indicators of cognitive reserve and behaviour change, to predict cognitive aging and diagnosis of dementia. Project methodology will rely partly on parametric ‘traditional’ multilevel- or fixed-effects modelling, partly on non-parametric statistical learning approaches, to address objectives both hypothesis- and data-driven. Applying statistical learning techniques in the field of cognitive reserve will open new research avenues for efficient handling of large amounts of data, among which most prominently the accurate prediction of health and disease outcomes. Quantifying the role of contextual inequalities related to education and gender will guide policymaking in and beyond the project. Assessing risk profiles of individuals in relation to cognitive aging will support efficient and scalable risk screening of individuals. Identifying the value of behaviour change to delay cognitive impairment will guide treatment plans for individuals affected by dementia.
Summary
Cognitive impairment and dementia have dramatic individual and social consequences, and create high economic costs for societies. In order to delay cognitive aging of future generations as long as possible, we need evidence about which contextual factors are most supportive for individuals to reach highest cognitive levels relative to their potential. At the same time, for current older generations, we need scalable methods to exactly identify individuals at risk of cognitive impairment. The project intends to apply recent methodological and statistical advancements to reach two objectives. Firstly, contextual influences on cognitive aging will be comparatively assessed, with a focus on inequalities related to educational opportunities and gender inequalities. This will be done using longitudinal, population-representative, harmonized cross-national aging surveys, merged with contextual information. Secondly, the project will quantify the ability of singular and clustered individual characteristics, such as indicators of cognitive reserve and behaviour change, to predict cognitive aging and diagnosis of dementia. Project methodology will rely partly on parametric ‘traditional’ multilevel- or fixed-effects modelling, partly on non-parametric statistical learning approaches, to address objectives both hypothesis- and data-driven. Applying statistical learning techniques in the field of cognitive reserve will open new research avenues for efficient handling of large amounts of data, among which most prominently the accurate prediction of health and disease outcomes. Quantifying the role of contextual inequalities related to education and gender will guide policymaking in and beyond the project. Assessing risk profiles of individuals in relation to cognitive aging will support efficient and scalable risk screening of individuals. Identifying the value of behaviour change to delay cognitive impairment will guide treatment plans for individuals affected by dementia.
Max ERC Funding
1 148 290 €
Duration
Start date: 2019-01-01, End date: 2023-12-31
Project acronym IL7sigNETure
Project IL-7/IL-7R signaling networks in health and malignancy
Researcher (PI) João Pedro Taborda Barata
Host Institution (HI) INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES
Call Details Consolidator Grant (CoG), LS4, ERC-2014-CoG
Summary Deregulation of signal transduction is a feature of tumor cells and signaling therapies are gaining importance in the growing arsenal against cancer. However, their full potential can only be achieved once we overcome the limited knowledge on how signaling networks are wired in cancer cells. Interleukin 7 (IL7) and its receptor (IL7R) are essential for normal T-cell development and function. However, they can also promote autoimmunity, chronic inflammation and cancer. We showed that patients with T-cell acute lymphoblastic leukemia (T-ALL), an aggressive hematological cancer, can display IL7R gain-of-function mutations leading to downstream signaling activation and cell transformation. Despite the biological relevance of IL7 and IL7R, the characterization of their signaling effectors remains limited. Here, we propose to move from the single molecule/pathway-centered analysis that has characterized the research on IL7/IL7R signaling, into a ‘holistic’ view of the IL7/IL7R signaling landscape. To do so, we will employ a multidisciplinary strategy, in which data from complementary high throughput analyses, informing on different levels of regulation of the IL7/IL7R signaling network, will be integrated via a systems biology approach, and complemented by cell and molecular biology experimentation and state-of-the-art in vivo models. The knowledge we will generate should have a profound impact on the understanding of the fundamental mechanisms by which IL7/IL7R signaling promotes leukemia and reveal novel targets for fine-tuned therapeutic intervention in T-ALL. Moreover, the scope of insights gained should extend beyond leukemia. Our in-depth, systems-level characterization of IL7/IL7R signaling will constitute a platform with extraordinary potential to illuminate the molecular role of the IL7/IL7R axis in other cancers (e.g. breast and lung) and pathological settings where IL7 has been implicated, such as HIV infection, multiple sclerosis and rheumatoid arthritis.
Summary
Deregulation of signal transduction is a feature of tumor cells and signaling therapies are gaining importance in the growing arsenal against cancer. However, their full potential can only be achieved once we overcome the limited knowledge on how signaling networks are wired in cancer cells. Interleukin 7 (IL7) and its receptor (IL7R) are essential for normal T-cell development and function. However, they can also promote autoimmunity, chronic inflammation and cancer. We showed that patients with T-cell acute lymphoblastic leukemia (T-ALL), an aggressive hematological cancer, can display IL7R gain-of-function mutations leading to downstream signaling activation and cell transformation. Despite the biological relevance of IL7 and IL7R, the characterization of their signaling effectors remains limited. Here, we propose to move from the single molecule/pathway-centered analysis that has characterized the research on IL7/IL7R signaling, into a ‘holistic’ view of the IL7/IL7R signaling landscape. To do so, we will employ a multidisciplinary strategy, in which data from complementary high throughput analyses, informing on different levels of regulation of the IL7/IL7R signaling network, will be integrated via a systems biology approach, and complemented by cell and molecular biology experimentation and state-of-the-art in vivo models. The knowledge we will generate should have a profound impact on the understanding of the fundamental mechanisms by which IL7/IL7R signaling promotes leukemia and reveal novel targets for fine-tuned therapeutic intervention in T-ALL. Moreover, the scope of insights gained should extend beyond leukemia. Our in-depth, systems-level characterization of IL7/IL7R signaling will constitute a platform with extraordinary potential to illuminate the molecular role of the IL7/IL7R axis in other cancers (e.g. breast and lung) and pathological settings where IL7 has been implicated, such as HIV infection, multiple sclerosis and rheumatoid arthritis.
Max ERC Funding
1 988 125 €
Duration
Start date: 2015-09-01, End date: 2020-08-31
Project acronym iPROTECTION
Project Molecular mechanisms of induced protection against sepsis by DNA damage responses
Researcher (PI) Luis Filipe Ferreira Moita
Host Institution (HI) FUNDACAO CALOUSTE GULBENKIAN
Call Details Consolidator Grant (CoG), LS4, ERC-2014-CoG
Summary Severe sepsis remains a poorly understood systemic inflammatory condition with high mortality rates and limited therapeutic options outside of infection control and organ support measures. Based on our recent discovery that anthracycline drugs prevent organ failure without affecting the bacterial burden in a model of severe sepsis, we propose that strategies aimed at target organ protection have extraordinary potential for the treatment of sepsis and possibly for other inflammation-driven conditions. However, the mechanisms of organ protection and disease tolerance are either unknown or poorly characterized.
The central goal of the current proposal is to identify and characterize novel cytoprotective mechanisms, with a focus on DNA damage response dependent protection activated by anthracyclines as a window into stress-induced genetic programs conferring disease tolerance. To that end, we will carry out a combination of candidate and unbiased approaches for the in vivo identification of ATM-dependent and independent mechanisms of tissue protection. We will validate the leading candidates through adenovirus-mediated delivery of constructs for overexpression (gain-of-function) or shRNA for gene silencing (loss-of-function) to the lung, based on our recent finding that rescuing this organ is essential and perhaps sufficient in anthracycline-induced protection against severe sepsis. The candidates showing the most promise will be characterized using a combination of in vitro and in vivo genetic, biochemical, cell biological and physiological methods.
The results arising from the current proposal are likely not only to inspire the design of transformative therapies for sepsis but also to open a completely new field of opportunity to molecularly understand core surveillance mechanisms of basic cellular processes with a critical role in the homeostasis of organ function and whose activation can ultimately promote quality of life during aging and increase lifespan.
Summary
Severe sepsis remains a poorly understood systemic inflammatory condition with high mortality rates and limited therapeutic options outside of infection control and organ support measures. Based on our recent discovery that anthracycline drugs prevent organ failure without affecting the bacterial burden in a model of severe sepsis, we propose that strategies aimed at target organ protection have extraordinary potential for the treatment of sepsis and possibly for other inflammation-driven conditions. However, the mechanisms of organ protection and disease tolerance are either unknown or poorly characterized.
The central goal of the current proposal is to identify and characterize novel cytoprotective mechanisms, with a focus on DNA damage response dependent protection activated by anthracyclines as a window into stress-induced genetic programs conferring disease tolerance. To that end, we will carry out a combination of candidate and unbiased approaches for the in vivo identification of ATM-dependent and independent mechanisms of tissue protection. We will validate the leading candidates through adenovirus-mediated delivery of constructs for overexpression (gain-of-function) or shRNA for gene silencing (loss-of-function) to the lung, based on our recent finding that rescuing this organ is essential and perhaps sufficient in anthracycline-induced protection against severe sepsis. The candidates showing the most promise will be characterized using a combination of in vitro and in vivo genetic, biochemical, cell biological and physiological methods.
The results arising from the current proposal are likely not only to inspire the design of transformative therapies for sepsis but also to open a completely new field of opportunity to molecularly understand core surveillance mechanisms of basic cellular processes with a critical role in the homeostasis of organ function and whose activation can ultimately promote quality of life during aging and increase lifespan.
Max ERC Funding
1 985 375 €
Duration
Start date: 2015-10-01, End date: 2020-09-30
Project acronym PHONICS
Project Positioning the nucleus for cell migration and muscle fiber function
Researcher (PI) Edgar Rodrigues Almeida Gomes
Host Institution (HI) INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES
Call Details Consolidator Grant (CoG), LS4, ERC-2013-CoG
Summary The cell nucleus is positioned at specific places within the cytoplasm and this position is important for different cellular, developmental and physiological processes. Nuclear positioning depends on connections between nuclear envelope proteins and the cytoskeleton. In migrating cells, we found that the nucleus is positioned away from the front of the cell and this event is important for cell migration. We performed an RNAi screen for nuclear positioning and found new nuclear envelope proteins involved in nuclear positioning. In fully developed myofibers, nuclei are specifically positioned at the periphery of the myofiber, while during development and regeneration, as well as in multiple muscle pathologies, the nucleus is centrally positioned. We found new mechanisms drive nuclear movement during myofiber formation. We also showed that nuclear position is important for muscle function. However why nuclear positioning is important for myofiber activity remains an open question.
We now propose to use unique systems to monitor cell migration and myofiber formation in combination with biochemistry, cell biology, high- and super-resolution microscopy approaches to:
1) Identify novel molecular mechanisms that mediate nuclear positioning during cell migration and myofiber formation.
3) Determine a role for nuclear positioning in myofiber function as well as the significance of altered nuclear positioning in different forms of muscle pathology.
The proposed work will establish new mechanisms for nuclear positioning. Importantly, by identifying mechanisms and understanding the role of nuclear positioning in myofiber function, we will lay the foundations for future studies to ameliorate or treat muscle disorders as well as other conditions where nucleus positioning may prove to play a role such as cancer.
Summary
The cell nucleus is positioned at specific places within the cytoplasm and this position is important for different cellular, developmental and physiological processes. Nuclear positioning depends on connections between nuclear envelope proteins and the cytoskeleton. In migrating cells, we found that the nucleus is positioned away from the front of the cell and this event is important for cell migration. We performed an RNAi screen for nuclear positioning and found new nuclear envelope proteins involved in nuclear positioning. In fully developed myofibers, nuclei are specifically positioned at the periphery of the myofiber, while during development and regeneration, as well as in multiple muscle pathologies, the nucleus is centrally positioned. We found new mechanisms drive nuclear movement during myofiber formation. We also showed that nuclear position is important for muscle function. However why nuclear positioning is important for myofiber activity remains an open question.
We now propose to use unique systems to monitor cell migration and myofiber formation in combination with biochemistry, cell biology, high- and super-resolution microscopy approaches to:
1) Identify novel molecular mechanisms that mediate nuclear positioning during cell migration and myofiber formation.
3) Determine a role for nuclear positioning in myofiber function as well as the significance of altered nuclear positioning in different forms of muscle pathology.
The proposed work will establish new mechanisms for nuclear positioning. Importantly, by identifying mechanisms and understanding the role of nuclear positioning in myofiber function, we will lay the foundations for future studies to ameliorate or treat muscle disorders as well as other conditions where nucleus positioning may prove to play a role such as cancer.
Max ERC Funding
1 968 000 €
Duration
Start date: 2014-07-01, End date: 2019-06-30
Project acronym POLITICS
Project The politics of anti-racism in Europe and Latin America: knowledge production, decision-making and collective struggles
Researcher (PI) Silvia RODRIGUEZ MAESO
Host Institution (HI) CENTRO DE ESTUDOS SOCIAIS
Call Details Consolidator Grant (CoG), SH3, ERC-2016-COG
Summary The main objective of POLITICS is to innovate knowledge on anti-racism that brings about a greater understanding of how historically rooted injustices are being challenged by institutions and grassroots movements. Considering the centrality and mutual influence of Europe and Latin America in the global processes of racial formation, POLITICS will develop an inter-disciplinary and comprehensive approach towards two core goals: (a) the analysis of processes of knowledge production about ‘race’ and (anti-)racism in the spheres of (inter)national governmental politics, State universities and grassroots movements; (b) the examination of diverse paths of denunciation and collective mobilisation against everyday racism concerning police practice and representations in the mass media.
POLITICS embraces a multilevel analysis and information-oriented selection of case-studies in three interrelated research streams: (i) Global, regional and state-sponsored political frameworks and public policies; (ii) Cultures of scholarship and the study of racism and (post)colonialism at State universities; (iii) Tackling everyday racism: processes of denunciation, political mobilisation and case-law concerning police practice, and racist representations in the media and mass media. The research challenges the shortcomings of evaluative comparisons and the selection of research contexts enables interrogating the relations between the global, national and local levels. They include the Organisation of American States, the European Union and national and local politics in Brazil, Peru, Portugal and Spain. Qualitative research and data collection engage with race critical theories, critical discourse analysis and participatory methods that consider power/knowledge at their core.
POLITICS will unravel the configuration of different notions of dignity, justice and equality resulting from anti-racist struggles and policy interventions and their significance for envisaging decolonial horizons.
Summary
The main objective of POLITICS is to innovate knowledge on anti-racism that brings about a greater understanding of how historically rooted injustices are being challenged by institutions and grassroots movements. Considering the centrality and mutual influence of Europe and Latin America in the global processes of racial formation, POLITICS will develop an inter-disciplinary and comprehensive approach towards two core goals: (a) the analysis of processes of knowledge production about ‘race’ and (anti-)racism in the spheres of (inter)national governmental politics, State universities and grassroots movements; (b) the examination of diverse paths of denunciation and collective mobilisation against everyday racism concerning police practice and representations in the mass media.
POLITICS embraces a multilevel analysis and information-oriented selection of case-studies in three interrelated research streams: (i) Global, regional and state-sponsored political frameworks and public policies; (ii) Cultures of scholarship and the study of racism and (post)colonialism at State universities; (iii) Tackling everyday racism: processes of denunciation, political mobilisation and case-law concerning police practice, and racist representations in the media and mass media. The research challenges the shortcomings of evaluative comparisons and the selection of research contexts enables interrogating the relations between the global, national and local levels. They include the Organisation of American States, the European Union and national and local politics in Brazil, Peru, Portugal and Spain. Qualitative research and data collection engage with race critical theories, critical discourse analysis and participatory methods that consider power/knowledge at their core.
POLITICS will unravel the configuration of different notions of dignity, justice and equality resulting from anti-racist struggles and policy interventions and their significance for envisaging decolonial horizons.
Max ERC Funding
1 915 381 €
Duration
Start date: 2017-09-01, End date: 2022-08-31
Project acronym ReSEED
Project Rescuing seeds’ heritage: engaging in a new framework of agriculture and innovation since the 18th century
Researcher (PI) Maria Dulce ALVES FREIRE
Host Institution (HI) INSTITUTO DE CIENCIAS SOCIAIS
Call Details Starting Grant (StG), SH3, ERC-2017-STG
Summary Humanity is facing a huge challenge: how to feed a growing population in a sustainable way? Scientists from different fields are looking for answers and ReSEED aims to assist such endeavours. Solutions depend on one key issue: seeds. We can have appropriate soil, climate or technologies, however without proper seeds it is impossible to guarantee food production. As historiography has given little attention to the role of seed varieties, there are many gaps in scientific knowledge. I argue that long-term historical analysis is critical to provide the best answers to current questions. ReSEED examines the changing connections between seeds, environment and human action, the triangle that has always underpinned agriculture, since the 18th century. The main objectives are as follows. 1) To map geographical changes in local crop distribution, paying attention to the new seeds made available by Columbian Exchange. 2) To outline which were the social networks supporting the circulation and cultivation of edible seed varieties, and at later date, checking how they articulated with state services. 3) To identify human factors that contribute to reducing, increasing, maintaining or restoring regional agro-biodiversity. 4) To assess the impacts of national and international decisions on local management of the triangle, mainly on farmers’ innovation. 5) To re-examine the long-term dynamics behind various European agricultural modernization itineraries. Based on innovative interdisciplinary and transdisciplinary methodologies, I build robust empirical research on the case of Iberian Peninsula in connection to empires, which allows thorough comparisons with other regions in Europe and beyond. ReSEED promotes strategies for win-win environmental/society outcomes, linking edible seeds to places and to innovations needed for food production. This is crucial to better understand how historical experiences can contribute to create solutions that ensure sustainable futures.
Summary
Humanity is facing a huge challenge: how to feed a growing population in a sustainable way? Scientists from different fields are looking for answers and ReSEED aims to assist such endeavours. Solutions depend on one key issue: seeds. We can have appropriate soil, climate or technologies, however without proper seeds it is impossible to guarantee food production. As historiography has given little attention to the role of seed varieties, there are many gaps in scientific knowledge. I argue that long-term historical analysis is critical to provide the best answers to current questions. ReSEED examines the changing connections between seeds, environment and human action, the triangle that has always underpinned agriculture, since the 18th century. The main objectives are as follows. 1) To map geographical changes in local crop distribution, paying attention to the new seeds made available by Columbian Exchange. 2) To outline which were the social networks supporting the circulation and cultivation of edible seed varieties, and at later date, checking how they articulated with state services. 3) To identify human factors that contribute to reducing, increasing, maintaining or restoring regional agro-biodiversity. 4) To assess the impacts of national and international decisions on local management of the triangle, mainly on farmers’ innovation. 5) To re-examine the long-term dynamics behind various European agricultural modernization itineraries. Based on innovative interdisciplinary and transdisciplinary methodologies, I build robust empirical research on the case of Iberian Peninsula in connection to empires, which allows thorough comparisons with other regions in Europe and beyond. ReSEED promotes strategies for win-win environmental/society outcomes, linking edible seeds to places and to innovations needed for food production. This is crucial to better understand how historical experiences can contribute to create solutions that ensure sustainable futures.
Max ERC Funding
1 467 727 €
Duration
Start date: 2018-11-01, End date: 2023-10-31
