ERC FUNDED PROJECTS

To satisfy our growing energy demand while reducing reliance on fossil fuels, a switch to renewable energy sources is vital. The intermittent nature of the latter means innovations in energy storage technology is a key grand challenge. Cost and sustainability issues currently limit the widespread use of electrochemical energy storage technologies, such as lithium ion and redox flow batteries. As the scale for energy storage is simply enormous, the only option is to look for abundant materials. However, compounds that fulfil the extensive requirements entailed at low cost has yet to be reported. While it is possible that the holy grail of energy storage will be found, for example by advanced computational tools and machine learning to design “perfect” abundant molecules, a more flexible, innovative solution to sustainable and cost-effective large-scale energy storage is required. Bi3BoostFlowBat will develop game changing strategies to widen the choice of compounds utilizable for batteries to simultaneously satisfy the requirements for low cost, optimal redox potentials, high solubility and stability in all conditions. The aim of this project is to develop cost-efficient batteries by using solid boosters and by eliminating cross over. Two approaches will be pursued for cross-over elimination 1) bio-inspired polymer batteries, where cross-over of solubilized polymers is prevented by size-exclusion membranes and 2) biphasic emulsion flow batteries, where redox species are transferred to oil phase droplets upon charge. Third research direction focuses on systems to maintain a pH gradient, to allow operation of differential pH systems to improve the cell voltages. Limits of different approaches will be explored by taking an electrochemical engineering approach to model the performance of different systems and by validating the models experimentally. This work will chart the route towards the future third generation battery technologies for the large-scale energy storage.

1 499 880 €

Start date: 2021-01-01, End date: 2025-12-31

Anxiety disorders include different forms of pathological fear and anxiety and rank among the most common health concerns in human medicine. Millions of people become affected every year, and many of them do not respond to treatments. Anxiety disorders are heritable, but genetically complex. As a result, traditional gene mapping methods in the human population with prominent locus and allelic heterogeneity have not succeeded. Similarly, rodents have provided some insights into the circuitry of anxiety, but naturally occurring versions do not exist and gene deletion studies have not provided adequate models. To break through and identify new anxiety genes, I propose a novel and unique approach that resorts to man s best friend, dog. Taking advantage of the exaggerated genetic homogeneity characteristic of purebred dogs, recent genomics tools and the existence of naturally occurring heritable behaviour disorders in dogs can remedy the current lack of a suitable animal model of human psychiatric disorders. I propose to collect and perform a genome-wide association study in four breed-specific anxiety traits in dogs representing the three major forms of human anxiety: compulsive pacing and tail-chasing, noise phobia, and shyness corresponding to human OCD, panic disorder and social phobia, respectively. Canine anxiety disorders respond to human medications and other phenomenological studies suggest a share biological mechanism in both species. The proposed research has the potential to discover new genetic risk factors, which eventually will shed light on the biological basis of common neuropsychiatric disorders in both dog and human, provide insight into etiological mechanisms, enable identification of individuals at high-risk for adverse health outcomes, and facilitate development of tailored treatments.

1 381 807 €

Start date: 2010-10-01, End date: 2015-09-30

The problematic of transnational cultural heritage has become topical in a new way in Europe with the utilization of the idea of heritage for political purposes in the EU policy. Since the turn of the century, the EU has launched or jointly administered several initiatives focusing on fostering the idea of a common European cultural heritage. The heritage initiatives are the EU’s ‘technologies of power’ aiming to legitimate and justify certain political ideas and ideologies, such as European-wide identity politics and the cultural integration in Europe. However, the politics, discourses, and practices of heritage—and of transnational heritage in particular—are often intertwined with contentions over its symbolical and factual ownership, meanings, and uses. The project investigates the EU as a new heritage agent and its heritage politics as an attempt to create a new trans-European heritage regime in Europe: How does the EU aim to create common European cultural heritage in a politically shaking and culturally diversified Europe, and what kind of explicit and implicit politics are included in its aims? The project will focus on the legitimation processes of European cultural heritage at different territorial levels and the power relations formed in the processes between diverse agencies. The academia still lacks a comparative empirical investigation on the politics and practices of trans-European cultural heritage and the theoretical discussion on the role of the EU in them. The project aims to respond to this lack with a broad comparative empirical research including cases from various parts of Europe, penetrating different territorial scales (local, regional, national, and the EU), and theorizing cultural heritage from a multisectional perspective (stressing its concurrent use in diverse societal domains and discourses). The project participates in a critical discussion on the current identity and integration politics and policies in the EU and Europe.

1 339 755 €

Start date: 2015-09-01, End date: 2020-08-31

Glucose is key source of nutritional energy and raw material for biosynthetic processes. Maintaining glucose homeostasis requires a regulatory network that functions both in the systemic level through hormonal signaling and locally at the intracellular level. Insulin signalling is the main hormonal mechanism involved in maintaining the levels of circulating glucose through regulation of cellular glucose intake and metabolism. While the signalling pathways mediating the effects of insulin have been thoroughly studied, the transcriptional networks downstream of insulin signalling are not comprehensively understood. In addition to insulin signalling, intracellular glucose sensing mechanisms, including transcription factor complex MondoA/B-Mlx, have recently emerged as important regulators of glucose metabolism. In the proposed project we aim to take a systematic approach to characterize the transcriptional regulators involved in glucose sensing and metabolism in physiological context, using Drosophila as the main model system. We will use several complementary screening strategies, both in vivo and in cell culture, to identify transcription factors regulated by insulin and intracellular glucose. Identified transcription factors will be exposed to a panel of in vivo tests measuring parameters related to glucose and energy metabolism, aiming to identify those transcriptional regulators most essential in maintaining glucose homeostasis. With these factors, we will proceed to in-depth analysis, generating mutant alleles, analysing their metabolic profile and physiologically important target genes as well as functional conservation in mammals. Our aim is to identify and characterize several novel transcriptional regulators involved in glucose metabolism and to achieve a comprehensive overview on how these transcriptional regulators act together to achieve metabolic homeostasis in response to fluctuating dietary glucose intake.

1 496 930 €

Start date: 2012-01-01, End date: 2017-02-28