ERC FUNDED PROJECTS

Which physical principles govern life regulation at the level of subcellular, membrane-enclosed nanosystems, such as transport vesicles and organelles? How do they achieve controlled movements across the crowded intracellular world? Which is the structural and functional organization of their surface and their lumen? This is only a small subset of key open questions that the biophysical approach envisaged here will allow to answer directly within living matter, for the first time. Thus far, state-of-the-art optical microscopy tools for delivering quantitative information in living matter failed to subtract the natural 3D movement of subcellular nanosystems while preserving the spatial and temporal resolution required to probe their structure and function at the molecular level. CAPTUR3D will tackle this bottleneck. An excitation light-beam will be focused in a periodic orbit around the nanosystem of interest and used to localize its position with unprecedented spatial (~10 nm) and temporal (~1000 Hz frequency response) resolution. Such privileged observation point will push biophysical investigations to a new level. For the first time, state-of-the-art imaging technologies and analytical tools (e.g. fluorescence correlation spectroscopy), will be used to perform molecular investigations on a moving, nanoscopic reference system. The insulin secretory granule (ISG) is selected as a paradigmatic case study. Key open issues at the ISG level are selected, namely: (i) ISG-environment interactions and their role in directing ISG trafficking, (ii) ISG-membrane spatiotemporal organization, (iii) ISG-lumen structural and functional organization, (iv) ISG alterations in type-2 diabetes (T2D). These issues will be tackled directly within human-derived Langherans islets. CAPTUR3D is envisioned not only to foster our knowledge on T2D physiopathology but also to concomitantly drive an unprecedented revolution in the way we address living matter at the subcellular scale.

1 985 750 €

Start date: 2021-03-01, End date: 2026-02-28

ELFO will provide the foundations of a new enabling technology for disruptive edible electronic systems, with applications in advanced biomedical devices for continuous monitoring of the health status within the gastro-intestinal (GI) tract, as well as in electronic tags for food monitoring, serving public health and providing at the same time a very powerful tool against counterfeiting. These systems will be unperceivable and mass produced mainly with mask-less, printing and direct-writing methods. Besides being completely safe for ingestion, such devices will also be perceived as food, favouring public acceptance. Such an ambitious plan will be implemented by: i) creating knowledge on electronic properties of food and food derivatives and complementing them with edible solution-processable, mainly carbon-based semiconductors, thus developing an extended library of edible electronic materials; ii) developing large-area, solution-based, printing and direct-writing scalable processes with high lateral resolution for the precise patterning of edible functional materials; iii) developing edible electronic components required in systems, from logic to power and sensors; iv) validating the progress with two proof-of-concept systems, an edible radio-frequency pill with controlled drug delivery, answering the need for compliance monitoring devices and actuators within the gut, and an edible passive food Radio-Frequency identification tag, answering the need for certification and anti-counterfeiting devices directly onto or into food products. ELFO will give solid engineering grounds to the visionary perspectives of edible electronics, introducing imperceptible intelligence in any edible item, thus accessing more information on what we eat, how it is assimilated and enabling biomedical devices for mass health screening.

1 980 000 €

Start date: 2020-09-01, End date: 2025-08-31

A new space era is fast approaching. A multitude of miniaturised probes will soon permeate the inner solar system. The abundantly variegated minor bodies will be the destinations of numerous missions driven by exploration and exploitation needs. Missions to rocky planets will feature networks of artificial satellites to support science and operations. Yet, the state-of-the-art is to pilot deep-space probes from ground. Although this is reliable, ground control slots will saturate soon, thus hampering the current momentum in space exploration. EXTREMA enables self-driving spacecraft: machines able to travel in the deep space free of human-driven instructions. We take the challenge to make these systems a reality, and fundamental research is conducted to lay down their foundations. The ambition of EXTREMA is to prove that minor bodies and inner planets can be reached in a totally autonomous fashion with highly constrained platforms. These systems are used to engineer ballistic capture, an extremely rare event observed in highly sensitive regimes. To reinforce this logic, a new approach in orbit validation is introduced, which excels pure computer simulations. Erected over three pillars, the project forges a Simulation Hub, which reproduces on ground the spacecraft-environment interaction. While the pillars enable intermediate milestones, such as inferring the spacecraft position by exploiting the surrounding environment (autonomous navigation), self-determining a nominal plan without a-priori knowledge (autonomous guidance), and targeting the corridors that conduce to ballistic capture, it is the activity performed in the Simulation Hub that allows achieving the objectives via dedicated case studies. A successful outcome will boost access to outer space. The impact is to favour settlements in the inner solar system on a large-scale basis. Located at the fringe of research, EXTREMA can determine a paradigm shift in the way we conceive and conduct deep-space mission.

1 972 837 €

Start date: 2021-01-01, End date: 2025-12-31

Soft magnetoactive materials can change their properties and undergo extremely large deformations when excited by magnetic stimuli. These reconfigurable soft materials hold great potential for a large variety of applications from sensing devices to energy harvesting, noise and vibration mitigation, and soft robotics. However, these materials operate at high magnetic fields, thus, limiting potential application of the technology. A promising approach to significantly enhance the magnetomechanical performance, and reduce the required magnetic field, is to design soft magnetoactive composites through architectured microstructures. Highly ordered microstructures are an origin for multiscale magnetomechanical instabilities and possible failure of the materials. In this research proposal, we directly address this crucial aspect for MAE-based technology. Moreover, we declare an ambitious goal: Turning failure into functionalities. Our strategy is to take the risk of operating MAEs in the unstable regime with predesigned instability developments. This novel MAE design concept will capitalize on controllable cascade microstructure transformations while attempting to avoid catastrophic failure. If successful, this concept will open a new avenue in design of morphing magnetoactive materials with new functionalities and superior performance. To achieve this ambitious goal, we will develop multiscale theoretical and computational frameworks to reveal and to predict the behavior of possible advantageous microstructures in the extreme regimes. If successful, we will fill the gap in magnetomechanical multiscale instability phenomena, and will significantly advance the frontier of knowledge about the reconfigurable soft matter. We will probe our ideas experimentally, and will fabricate the revealed advantageous materials with engineered microstructures and properties. We envision revealing the fundamental multiphysics mechanisms of the multiscale magnetomechanical instabilities.

1 999 085 €

Start date: 2020-03-01, End date: 2025-02-28