Project acronym CORKtheCAMBIA
Project Thickening of plant organs by nested stem cells
Researcher (PI) Ari Pekka MÄHÖNEN
Host Institution (HI) HELSINGIN YLIOPISTO
Call Details Consolidator Grant (CoG), LS3, ERC-2018-COG
Summary Growth originates from meristems, where stem cells are located. Lateral meristems, which provide thickness to tree stems and other plant organs, include vascular cambium (produces xylem [wood] and phloem); and cork cambium (forms cork, a tough protective layer).
We recently identified the molecular mechanism that specifies stem cells of vascular cambium. Unexpectedly, this same set of experiments revealed also novel aspects of the regulation of cork cambium, a meristem whose development has remained unknown. CORKtheCAMBIA aims to identify the stem cells of cork cambium and reveal how they mechanistically regulate plant organ thickening. Thus, stemming from these novel unpublished findings and my matching expertise on plant stem cells and lateral growth, the timing is perfect to discover the molecular mechanism underlying specification of stem cells of cork cambium.
To identify the origin of stem cells of cork cambium, 1st-we will combine lineage tracing with a detailed molecular marker analysis. To deduce the cell dynamics of cork cambium, 2nd-we will follow regeneration of the stem cells after ablation of this meristem. To discover the molecular factors regulating the stem cell specification of cork cambium, 3rd-we will utilize molecular genetics and a novel method (inducible CRISPR/Cas9 mutant targeting) being developed in my lab. Since the lateral growth is orchestrated by two adjacent, nested meristems, cork and vascular cambia, the growth process must be tightly co-regulated. Thus, 4th-an in silico model of the intertwined growth process will be generated. By combining modelling with experimentation, we will uncover mechanistically how cork and vascular cambium coordinate lateral growth.
CORKtheCAMBIA will thus provide long-awaited insight into the regulatory mechanisms specifying the stem cells of lateral meristem as whole, lay the foundation for studies on radial thickening and facilitate rational manipulation of lateral meristems of crop plants and trees.
Summary
Growth originates from meristems, where stem cells are located. Lateral meristems, which provide thickness to tree stems and other plant organs, include vascular cambium (produces xylem [wood] and phloem); and cork cambium (forms cork, a tough protective layer).
We recently identified the molecular mechanism that specifies stem cells of vascular cambium. Unexpectedly, this same set of experiments revealed also novel aspects of the regulation of cork cambium, a meristem whose development has remained unknown. CORKtheCAMBIA aims to identify the stem cells of cork cambium and reveal how they mechanistically regulate plant organ thickening. Thus, stemming from these novel unpublished findings and my matching expertise on plant stem cells and lateral growth, the timing is perfect to discover the molecular mechanism underlying specification of stem cells of cork cambium.
To identify the origin of stem cells of cork cambium, 1st-we will combine lineage tracing with a detailed molecular marker analysis. To deduce the cell dynamics of cork cambium, 2nd-we will follow regeneration of the stem cells after ablation of this meristem. To discover the molecular factors regulating the stem cell specification of cork cambium, 3rd-we will utilize molecular genetics and a novel method (inducible CRISPR/Cas9 mutant targeting) being developed in my lab. Since the lateral growth is orchestrated by two adjacent, nested meristems, cork and vascular cambia, the growth process must be tightly co-regulated. Thus, 4th-an in silico model of the intertwined growth process will be generated. By combining modelling with experimentation, we will uncover mechanistically how cork and vascular cambium coordinate lateral growth.
CORKtheCAMBIA will thus provide long-awaited insight into the regulatory mechanisms specifying the stem cells of lateral meristem as whole, lay the foundation for studies on radial thickening and facilitate rational manipulation of lateral meristems of crop plants and trees.
Max ERC Funding
1 999 752 €
Duration
Start date: 2019-09-01, End date: 2024-08-31
Project acronym COYOTE
Project Coherent Optics Everywhere: a New Dawn for Photonic Networks
Researcher (PI) Bernhard SCHRENK
Host Institution (HI) AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH
Call Details Starting Grant (StG), PE7, ERC-2018-STG
Summary The widespread adoption of the Internet and its influence on our daily life is unquestioned. Global Zettabyte traffic has rendered photonics as indispensable for the communication infrastructure. While direct signal detection has been dismissed in radio communications decades ago, it prevails in short- and medium-reach optics in virtue of its simplicity. In such an environment photonics can only rely on incremental improvements, whereas it desperately seeks for disruptive concepts.
COYOTE envisions a novel coherent homodyne transceiver concept for analogue signals and access to higher-order formats with efficiencies of 10 bits/symbol. On top of this, high-fidelity transport of multi-band 5G radio signals in the millimetre-wave range up to 100 GHz will be enabled by analogue coherent photonics while mitigating energy-hungry digital signal processing. COYOTE takes one more leap and dares the contradictory full-duplex data transmission in virtue of its novel reception engine to ultimately guarantee a lean solution with greatly simplified yet flexible “hardware”.
The key asset of COYOTE’s coherent engine will be a locked laser with improved coherence characteristics together with a flexible modulator-detector element, which is capable to emulate direct-detection systems in a transparent way while giving birth to novel networking concepts. Exploration of the 3D Stokes and 2D quadrature spaces through a segmented receiver architecture will boost the spectral efficiency to >10 bits/s/Hz.
It is the lean and yet efficient coherent transceiver methodology of COYOTE that will remove the currently existing boundary between direct-detection and coherent systems in the midst of network reaches. By coherently “reviving” these telecom segments of integrated wireline-wireless access networks, optical interconnects for intra-datacentre connectivity and even quantum communication, an order-of-magnitude improvement in terms of spectral efficiency x reach product will be gained.
Summary
The widespread adoption of the Internet and its influence on our daily life is unquestioned. Global Zettabyte traffic has rendered photonics as indispensable for the communication infrastructure. While direct signal detection has been dismissed in radio communications decades ago, it prevails in short- and medium-reach optics in virtue of its simplicity. In such an environment photonics can only rely on incremental improvements, whereas it desperately seeks for disruptive concepts.
COYOTE envisions a novel coherent homodyne transceiver concept for analogue signals and access to higher-order formats with efficiencies of 10 bits/symbol. On top of this, high-fidelity transport of multi-band 5G radio signals in the millimetre-wave range up to 100 GHz will be enabled by analogue coherent photonics while mitigating energy-hungry digital signal processing. COYOTE takes one more leap and dares the contradictory full-duplex data transmission in virtue of its novel reception engine to ultimately guarantee a lean solution with greatly simplified yet flexible “hardware”.
The key asset of COYOTE’s coherent engine will be a locked laser with improved coherence characteristics together with a flexible modulator-detector element, which is capable to emulate direct-detection systems in a transparent way while giving birth to novel networking concepts. Exploration of the 3D Stokes and 2D quadrature spaces through a segmented receiver architecture will boost the spectral efficiency to >10 bits/s/Hz.
It is the lean and yet efficient coherent transceiver methodology of COYOTE that will remove the currently existing boundary between direct-detection and coherent systems in the midst of network reaches. By coherently “reviving” these telecom segments of integrated wireline-wireless access networks, optical interconnects for intra-datacentre connectivity and even quantum communication, an order-of-magnitude improvement in terms of spectral efficiency x reach product will be gained.
Max ERC Funding
1 500 000 €
Duration
Start date: 2019-01-01, End date: 2023-12-31
Project acronym CRISPR2.0
Project Microbial genome defence pathways: from molecular mechanisms to next-generation molecular tools
Researcher (PI) Martin JINEK
Host Institution (HI) UNIVERSITAT ZURICH
Call Details Consolidator Grant (CoG), LS1, ERC-2018-COG
Summary The constant arms race between prokaryotic microbes and their molecular parasites such as viruses, plasmids and transposons has driven the evolution of complex genome defence mechanisms. The CRISPR-Cas defence systems provide adaptive RNA-guided immunity against invasive nucleic acid elements. CRISPR-associated effector nucleases such as Cas9, Cas12a and Cas13 have emerged as powerful tools for precision genome editing, gene expression control and nucleic acid detection. However, these technologies suffer from drawbacks that limit their efficacy and versatility, necessitating the search for additional exploitable molecular activities. Building on our recent structural and biochemical studies, the goal of this project is to investigate the molecular architectures and mechanisms of CRISPR-associated systems and other genome defence mechanisms, aiming not only to shed light on their biological roles but also inform their technological development. Specifically, the proposed studies will examine (i) the molecular basis of cyclic oligoadenylate signalling in type III CRISPR-Cas systems, (ii) the mechanism of transposon-associated type I CRISPR-Cas systems and their putative function in RNA-guided DNA transposition, and (iii) molecular activities associated with recently described non-CRISPR defence systems. Collectively, the proposed studies will advance our understanding of the molecular functions of genome defence mechanisms in shaping the evolution of prokaryotic genomes and make critical contributions to their development as novel genetic engineering tools.
Summary
The constant arms race between prokaryotic microbes and their molecular parasites such as viruses, plasmids and transposons has driven the evolution of complex genome defence mechanisms. The CRISPR-Cas defence systems provide adaptive RNA-guided immunity against invasive nucleic acid elements. CRISPR-associated effector nucleases such as Cas9, Cas12a and Cas13 have emerged as powerful tools for precision genome editing, gene expression control and nucleic acid detection. However, these technologies suffer from drawbacks that limit their efficacy and versatility, necessitating the search for additional exploitable molecular activities. Building on our recent structural and biochemical studies, the goal of this project is to investigate the molecular architectures and mechanisms of CRISPR-associated systems and other genome defence mechanisms, aiming not only to shed light on their biological roles but also inform their technological development. Specifically, the proposed studies will examine (i) the molecular basis of cyclic oligoadenylate signalling in type III CRISPR-Cas systems, (ii) the mechanism of transposon-associated type I CRISPR-Cas systems and their putative function in RNA-guided DNA transposition, and (iii) molecular activities associated with recently described non-CRISPR defence systems. Collectively, the proposed studies will advance our understanding of the molecular functions of genome defence mechanisms in shaping the evolution of prokaryotic genomes and make critical contributions to their development as novel genetic engineering tools.
Max ERC Funding
1 996 525 €
Duration
Start date: 2019-05-01, End date: 2024-04-30
Project acronym DIA
Project Deep Integration Agreements
Researcher (PI) Ralph Ossa
Host Institution (HI) UNIVERSITAT ZURICH
Call Details Consolidator Grant (CoG), SH1, ERC-2018-COG
Summary This project aims to improve our understanding of deep integration agreements, which have generated an extraordinary amount of controversy in recent years. Unlike ordinary trade agreements, deep integration agreements do not just focus on reducing tariff barriers but seek to achieve much broader economic integration. Prominent examples include the Transatlantic Trade and Investment Partnership (TTIP) negotiated between the EU and the US and the Comprehensive Economic and Trade Agreement (CETA) negotiated between the EU and Canada.
I proceed in three complementary parts, focusing on the most controversial deep integration issues. In a first part, I consider provisions regarding investor protection including the Investor-State Dispute Settlement System. My ambition is to provide a comprehensive theoretical treatment of international investment agreements, which sheds light on their fundamental purpose and assesses their real-world design. In a second part, I turn to efforts towards regulatory cooperation such as CETA’s Regulatory Cooperation Forum. Here, my goal is again to provide a broad theoretical analysis, which identifies the scope for regulatory cooperation and makes suggestions for their real-world design. In a third part, I study intellectual property rights protection, specifically the agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS). In particular, I propose to take a canonical model of intellectual property rights agreements to the data and quantitatively assess the efficiency and equity implications of TRIPS.
Summary
This project aims to improve our understanding of deep integration agreements, which have generated an extraordinary amount of controversy in recent years. Unlike ordinary trade agreements, deep integration agreements do not just focus on reducing tariff barriers but seek to achieve much broader economic integration. Prominent examples include the Transatlantic Trade and Investment Partnership (TTIP) negotiated between the EU and the US and the Comprehensive Economic and Trade Agreement (CETA) negotiated between the EU and Canada.
I proceed in three complementary parts, focusing on the most controversial deep integration issues. In a first part, I consider provisions regarding investor protection including the Investor-State Dispute Settlement System. My ambition is to provide a comprehensive theoretical treatment of international investment agreements, which sheds light on their fundamental purpose and assesses their real-world design. In a second part, I turn to efforts towards regulatory cooperation such as CETA’s Regulatory Cooperation Forum. Here, my goal is again to provide a broad theoretical analysis, which identifies the scope for regulatory cooperation and makes suggestions for their real-world design. In a third part, I study intellectual property rights protection, specifically the agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS). In particular, I propose to take a canonical model of intellectual property rights agreements to the data and quantitatively assess the efficiency and equity implications of TRIPS.
Max ERC Funding
1 433 281 €
Duration
Start date: 2019-01-01, End date: 2023-12-31
Project acronym DiRECT
Project Directly reprogrammed renal cells for targeted medicine
Researcher (PI) Soeren LIENKAMP
Host Institution (HI) UNIVERSITAT ZURICH
Call Details Starting Grant (StG), LS3, ERC-2018-STG
Summary The global incidence of kidney disease is on the rise, but little progress has been made to develop novel therapies or preventative measures.
New methods to generated renal tissue in vitro hold great promise for regenerative medicine and the prospect of organ replacement. Most of the strategies employed differentiate induced pluripotent stem cells (iPSCs) into kidney organoids, which can be derived from patient tissue.
Direct reprogramming is an alternative approach to convert one cell type into another using cell fate specifying transcription factors. We were the first to develop a method to directly reprogram mouse and human fibroblasts to kidney cells (induced renal tubular epithelial cells - iRECs) without the need for pluripotent cells. Morphological, transcriptomic and functional analyses found that directly reprogrammed iRECs are remarkably similar to native renal tubular cells. Direct reprogramming is fast, technically simple and scalable.
This proposal aims to establish direct reprogramming in nephrology and develop novel in vitro models for kidney diseases that primarily affect the renal tubules. We will unravel the mechanics of how only four transcription factors can change the morphology and function of fibroblasts towards a renal tubule cell identity. These insights will be used to identify alternative routes to directly reprogram tubule cells with increased efficiency and accuracy. We will identify cell type specifying factors for reprogramming of tubular segment specific cell types. Finally, we will use of reprogrammed kidney cells to establish new in vitro models for autosomal dominant polycystic kidney disease and nephronophthisis.
Direct reprogramming holds enormous potential to deliver patient specific disease models for diagnostic and therapeutic applications in the age of personalized and targeted medicine.
Summary
The global incidence of kidney disease is on the rise, but little progress has been made to develop novel therapies or preventative measures.
New methods to generated renal tissue in vitro hold great promise for regenerative medicine and the prospect of organ replacement. Most of the strategies employed differentiate induced pluripotent stem cells (iPSCs) into kidney organoids, which can be derived from patient tissue.
Direct reprogramming is an alternative approach to convert one cell type into another using cell fate specifying transcription factors. We were the first to develop a method to directly reprogram mouse and human fibroblasts to kidney cells (induced renal tubular epithelial cells - iRECs) without the need for pluripotent cells. Morphological, transcriptomic and functional analyses found that directly reprogrammed iRECs are remarkably similar to native renal tubular cells. Direct reprogramming is fast, technically simple and scalable.
This proposal aims to establish direct reprogramming in nephrology and develop novel in vitro models for kidney diseases that primarily affect the renal tubules. We will unravel the mechanics of how only four transcription factors can change the morphology and function of fibroblasts towards a renal tubule cell identity. These insights will be used to identify alternative routes to directly reprogram tubule cells with increased efficiency and accuracy. We will identify cell type specifying factors for reprogramming of tubular segment specific cell types. Finally, we will use of reprogrammed kidney cells to establish new in vitro models for autosomal dominant polycystic kidney disease and nephronophthisis.
Direct reprogramming holds enormous potential to deliver patient specific disease models for diagnostic and therapeutic applications in the age of personalized and targeted medicine.
Max ERC Funding
1 499 917 €
Duration
Start date: 2019-03-01, End date: 2024-02-29
Project acronym DISINTEGRATION
Project The Mass Politics of Disintegration
Researcher (PI) Stefanie Walter
Host Institution (HI) UNIVERSITAT ZURICH
Call Details Consolidator Grant (CoG), SH2, ERC-2018-COG
Summary In the past few years, there has been a growing popular backlash against international institutions. Examples include the 2015 Greek bailout referendum, the 2016 Brexit referendum, or the 2016 election of a US President seemingly determined to withdraw US support from various international treaties. The implications of these mass-based disintegration efforts reach far beyond the countries in which they originate. First, the disintegration process is shaped by how remaining member states respond to one member’s bid to unilaterally change or terminate the terms of an existing international agreement. Second, mass-based disintegration bids pose considerable political contagion risks by encouraging disintegrative tendencies in other countries. Unfortunately, our theoretical tools to understand such international disintegration processes are underdeveloped. DISINTEGRATION therefore conducts a broad, systematic, and comparative inquiry into the mass politics of disintegration that pays particular attention to reactions in the remaining member states. It explores when and how one country’s mass-based disintegration experience encourages or deters demands for disintegration in other countries, how these contagion effects are transmitted through domestic elites and domestic discourse, and how the remaining member states ultimately respond during disintegration negotiations. It undertakes large-scale multi-method data collection that exploits the research opportunities offered by two ongoing mass-based disintegration processes: the Brexit negotiations and an upcoming Swiss referendum aimed at terminating a Swiss-EU bilateral treaty. DISINTEGRATION’s main objective is to develop a much-needed theory of mass-based disintegration that helps us understand the transnational dynamics that unfold between governments, political elites and the mass public when one member state attempts to unilaterally withdraw from an international agreement on the basis of widespread popular support.
Summary
In the past few years, there has been a growing popular backlash against international institutions. Examples include the 2015 Greek bailout referendum, the 2016 Brexit referendum, or the 2016 election of a US President seemingly determined to withdraw US support from various international treaties. The implications of these mass-based disintegration efforts reach far beyond the countries in which they originate. First, the disintegration process is shaped by how remaining member states respond to one member’s bid to unilaterally change or terminate the terms of an existing international agreement. Second, mass-based disintegration bids pose considerable political contagion risks by encouraging disintegrative tendencies in other countries. Unfortunately, our theoretical tools to understand such international disintegration processes are underdeveloped. DISINTEGRATION therefore conducts a broad, systematic, and comparative inquiry into the mass politics of disintegration that pays particular attention to reactions in the remaining member states. It explores when and how one country’s mass-based disintegration experience encourages or deters demands for disintegration in other countries, how these contagion effects are transmitted through domestic elites and domestic discourse, and how the remaining member states ultimately respond during disintegration negotiations. It undertakes large-scale multi-method data collection that exploits the research opportunities offered by two ongoing mass-based disintegration processes: the Brexit negotiations and an upcoming Swiss referendum aimed at terminating a Swiss-EU bilateral treaty. DISINTEGRATION’s main objective is to develop a much-needed theory of mass-based disintegration that helps us understand the transnational dynamics that unfold between governments, political elites and the mass public when one member state attempts to unilaterally withdraw from an international agreement on the basis of widespread popular support.
Max ERC Funding
1 998 626 €
Duration
Start date: 2019-05-01, End date: 2024-04-30
Project acronym DIVLAW
Project How God Became a Lawgiver: The Place of the Torah in Ancient Near Eastern Legal History
Researcher (PI) Konrad Schmid
Host Institution (HI) UNIVERSITAT ZURICH
Call Details Advanced Grant (AdG), SH6, ERC-2018-ADG
Summary The Torah’s notion of divine law fundamentally transforms the nature of law found in its ancient Near Eastern context. Typically kings—not gods—took on the role of the promulgation of laws. The Torah’s conception of God as lawgiver emerged gradually through historical processes, rather than constituting the bedrock of the Bible’s literary and legal history. And, while scholars have long recognized the uniqueness of the Torah’s conception, its early historical development has received little attention. Only tangential analysis exists on the forces surrounding the genesis of the Torah’s notion of divine laws within ancient Near Eastern legal history or its impact on religion and politics in the early historical contexts of ancient Israel and Judah.
This project therefore aims: 1) to explicate the anchoring of law in the religious ether of the Ancient Near East; 2) to elucidate for the first time the intellectual processes in ancient Israel and Judah that led to the notion of divine laws and God as lawgiver, drawing comparisons with other legal understandings and practices from the ancient Near East; 3) to assess the socio-political and religious impact of this notion with ancient Judaism through the Hellenistic Period; and 4) to contextualize this development in the ancient world in comparison to parallel developments in Greek polities.
The project’s innovative potential lies in: 1) the evaluation of the divine laws as a historical phenomenon; 2) the neglected effort to understand their intellectual genesis and early development in a reciprocal relation to their socio-political context; 3) the cross-cultural analysis of ancient Israel and Judah and its neighbouring cultures in this regard; and 4) the application of a longue durée and realgeschichtliche perspective to largely literary and philological disciplines. These investigations offer a new paradigm for elucidating the webs connecting divinity, law, and socio-political developments in the first millennium BCE.
Summary
The Torah’s notion of divine law fundamentally transforms the nature of law found in its ancient Near Eastern context. Typically kings—not gods—took on the role of the promulgation of laws. The Torah’s conception of God as lawgiver emerged gradually through historical processes, rather than constituting the bedrock of the Bible’s literary and legal history. And, while scholars have long recognized the uniqueness of the Torah’s conception, its early historical development has received little attention. Only tangential analysis exists on the forces surrounding the genesis of the Torah’s notion of divine laws within ancient Near Eastern legal history or its impact on religion and politics in the early historical contexts of ancient Israel and Judah.
This project therefore aims: 1) to explicate the anchoring of law in the religious ether of the Ancient Near East; 2) to elucidate for the first time the intellectual processes in ancient Israel and Judah that led to the notion of divine laws and God as lawgiver, drawing comparisons with other legal understandings and practices from the ancient Near East; 3) to assess the socio-political and religious impact of this notion with ancient Judaism through the Hellenistic Period; and 4) to contextualize this development in the ancient world in comparison to parallel developments in Greek polities.
The project’s innovative potential lies in: 1) the evaluation of the divine laws as a historical phenomenon; 2) the neglected effort to understand their intellectual genesis and early development in a reciprocal relation to their socio-political context; 3) the cross-cultural analysis of ancient Israel and Judah and its neighbouring cultures in this regard; and 4) the application of a longue durée and realgeschichtliche perspective to largely literary and philological disciplines. These investigations offer a new paradigm for elucidating the webs connecting divinity, law, and socio-political developments in the first millennium BCE.
Max ERC Funding
2 500 000 €
Duration
Start date: 2020-01-01, End date: 2024-12-31
Project acronym DYNAPOL
Project Modeling approaches toward bioinspired dynamic materials
Researcher (PI) Giovanni Maria PAVAN
Host Institution (HI) SCUOLA UNIVERSITARIA PROFESSIONALE DELLA SVIZZERA ITALIANA
Call Details Consolidator Grant (CoG), PE4, ERC-2018-COG
Summary Nature uses self-assembly to build fascinating supramolecular materials, such as microtubules and protein filaments, that can self-heal, reconfigure, adapt or respond to specific stimuli in dynamic way. Building synthetic (polymeric) supramolecular materials possessing similar bioinspired properties via the same self-assembly principles is interesting for many applications. But their rational design requires a detailed comprehension of the molecular determinants controlling the assembly (structure, dynamics and properties) that is typically very difficult to reach experimentally.
The aim of this project is to obtain structure-dynamics-property relationships to learn how to control the dynamic bioinspired properties of supramolecular polymers. I propose to unravel the molecular origin of the bioinspired behavior through massive multiscale modeling, advanced simulations and machine learning. First, we will develop ad hoc molecular models to study monomer assembly and the supramolecular structure of various types of self-assembled materials on multiple scales. Second, using advanced simulation approaches we will characterize the supramolecular dynamics of these materials (dynamic exchange of monomers) at high (submolecular) resolution. We will then study bioinspired properties such as the ability of various supramolecular materials to self-heal, adapt or reconfigure dynamically in response to specific stimuli. Our models will be systematically validated by comparison with the experimental evidence from our collaborators. Finally, we will use machine learning approaches to analyze our high-resolution simulations and to identify the key monomer features that control and determine the structure, dynamics and dynamic properties of a supramolecular material (i.e., structure-dynamics-property relationships). This research will produce unprecedented insight and fundamental models for the rational design of artificial dynamic materials with controllable bioinspired properties.
Summary
Nature uses self-assembly to build fascinating supramolecular materials, such as microtubules and protein filaments, that can self-heal, reconfigure, adapt or respond to specific stimuli in dynamic way. Building synthetic (polymeric) supramolecular materials possessing similar bioinspired properties via the same self-assembly principles is interesting for many applications. But their rational design requires a detailed comprehension of the molecular determinants controlling the assembly (structure, dynamics and properties) that is typically very difficult to reach experimentally.
The aim of this project is to obtain structure-dynamics-property relationships to learn how to control the dynamic bioinspired properties of supramolecular polymers. I propose to unravel the molecular origin of the bioinspired behavior through massive multiscale modeling, advanced simulations and machine learning. First, we will develop ad hoc molecular models to study monomer assembly and the supramolecular structure of various types of self-assembled materials on multiple scales. Second, using advanced simulation approaches we will characterize the supramolecular dynamics of these materials (dynamic exchange of monomers) at high (submolecular) resolution. We will then study bioinspired properties such as the ability of various supramolecular materials to self-heal, adapt or reconfigure dynamically in response to specific stimuli. Our models will be systematically validated by comparison with the experimental evidence from our collaborators. Finally, we will use machine learning approaches to analyze our high-resolution simulations and to identify the key monomer features that control and determine the structure, dynamics and dynamic properties of a supramolecular material (i.e., structure-dynamics-property relationships). This research will produce unprecedented insight and fundamental models for the rational design of artificial dynamic materials with controllable bioinspired properties.
Max ERC Funding
1 999 623 €
Duration
Start date: 2019-06-01, End date: 2024-05-31
Project acronym EllipticPDE
Project Regularity and singularities in elliptic PDE's: beyond monotonicity formulas
Researcher (PI) Xavier ROS-OTON
Host Institution (HI) UNIVERSITAT ZURICH
Call Details Starting Grant (StG), PE1, ERC-2018-STG
Summary One of the oldest and most important questions in PDE theory is that of regularity. A classical example is Hilbert's XIXth problem (1900), solved by De Giorgi and Nash in 1956. During the second half of the XXth century, the regularity theory for elliptic and parabolic PDE's experienced a huge development, and many fundamental questions were answered by Caffarelli, Nirenberg, Krylov, Evans, Nadirashvili, Friedman, and many others. Still, there are problems of crucial importance that remain open.
The aim of this project is to go significantly beyond the state of the art in some of the most important open questions in this context. In particular, three key objectives of the project are the following. First, to introduce new techniques to obtain fine description of singularities in nonlinear elliptic PDE's. Aside from its intrinsic interest, a good regularity theory for singular points is likely to provide insightful applications in other contexts. A second aim of the project is to establish generic regularity results for free boundaries and other PDE problems. The development of methods which would allow one to prove generic regularity results may be viewed as one of the greatest challenges not only for free boundary problems, but for PDE problems in general. Finally, the third main objective is to achieve a complete regularity theory for nonlinear elliptic PDE's that does not rely on monotonicity formulas. These three objectives, while seemingly different, are in fact deeply interrelated.
Summary
One of the oldest and most important questions in PDE theory is that of regularity. A classical example is Hilbert's XIXth problem (1900), solved by De Giorgi and Nash in 1956. During the second half of the XXth century, the regularity theory for elliptic and parabolic PDE's experienced a huge development, and many fundamental questions were answered by Caffarelli, Nirenberg, Krylov, Evans, Nadirashvili, Friedman, and many others. Still, there are problems of crucial importance that remain open.
The aim of this project is to go significantly beyond the state of the art in some of the most important open questions in this context. In particular, three key objectives of the project are the following. First, to introduce new techniques to obtain fine description of singularities in nonlinear elliptic PDE's. Aside from its intrinsic interest, a good regularity theory for singular points is likely to provide insightful applications in other contexts. A second aim of the project is to establish generic regularity results for free boundaries and other PDE problems. The development of methods which would allow one to prove generic regularity results may be viewed as one of the greatest challenges not only for free boundary problems, but for PDE problems in general. Finally, the third main objective is to achieve a complete regularity theory for nonlinear elliptic PDE's that does not rely on monotonicity formulas. These three objectives, while seemingly different, are in fact deeply interrelated.
Max ERC Funding
1 335 250 €
Duration
Start date: 2019-01-01, End date: 2023-12-31
Project acronym EMPOWER
Project Medium Voltage Direct Current Electronic Transformer
Researcher (PI) Drazen DUJIC
Host Institution (HI) ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Call Details Consolidator Grant (CoG), PE7, ERC-2018-COG
Summary More than a century ago, the invention of alternating current (AC) transformer has made AC the preferred choice over the direct current (DC) technologies. Line AC transformers are bulky but simple and reliable devices, made out of copper and iron, providing voltage adaptation and galvanic isolation in AC power systems.
Currently, DC technology is increasing its presence in AC power systems, enabled by progress in semiconductor devices and power electronics based energy conversion. DC power distribution networks can effectively support energy transformation and high penetration of distributed energy resources and energy storage integration (both increasingly being DC by nature) in future energy systems. Despite this shift towards the DC power distribution networks, DC Transformer, offering AC transformer like features (and beyond) does not exist, either conceptually or practically.
To enable the next (r)evolution in power systems, the EMPOWER project will develop the DC Transformer, a novel, flexible, highly efficient, compact, and reliable conversion principle for seamless energy routing in high-power DC distribution networks. Through a holistic approach, novel concepts, integration and optimization, we will demonstrate new design paradigms for galvanically-isolated power conversion. Our approach relies on resonant conversion utilizing high-voltage semiconductor devices in combination with high-frequency magnetic materials. We propose a new approach for the DC Transformer, avoiding active power flow control and instead utilizing control effort for the safety and protection. The DC Transformer will unify functions of a power converter and a protection device into a single power electronics system, improving drastically the conversion efficiency, reliability and power density in future DC power distribution networks. The success of this project will place Europe at the edge of reliable, efficient and safe energy distribution and transmission technologies.
Summary
More than a century ago, the invention of alternating current (AC) transformer has made AC the preferred choice over the direct current (DC) technologies. Line AC transformers are bulky but simple and reliable devices, made out of copper and iron, providing voltage adaptation and galvanic isolation in AC power systems.
Currently, DC technology is increasing its presence in AC power systems, enabled by progress in semiconductor devices and power electronics based energy conversion. DC power distribution networks can effectively support energy transformation and high penetration of distributed energy resources and energy storage integration (both increasingly being DC by nature) in future energy systems. Despite this shift towards the DC power distribution networks, DC Transformer, offering AC transformer like features (and beyond) does not exist, either conceptually or practically.
To enable the next (r)evolution in power systems, the EMPOWER project will develop the DC Transformer, a novel, flexible, highly efficient, compact, and reliable conversion principle for seamless energy routing in high-power DC distribution networks. Through a holistic approach, novel concepts, integration and optimization, we will demonstrate new design paradigms for galvanically-isolated power conversion. Our approach relies on resonant conversion utilizing high-voltage semiconductor devices in combination with high-frequency magnetic materials. We propose a new approach for the DC Transformer, avoiding active power flow control and instead utilizing control effort for the safety and protection. The DC Transformer will unify functions of a power converter and a protection device into a single power electronics system, improving drastically the conversion efficiency, reliability and power density in future DC power distribution networks. The success of this project will place Europe at the edge of reliable, efficient and safe energy distribution and transmission technologies.
Max ERC Funding
2 198 145 €
Duration
Start date: 2019-06-01, End date: 2024-05-31