ERC FUNDED PROJECTS

An inflation-probing B-mode signal in the polarization of the cosmic microwave background (CMB) would be a discovery of utmost importance in physics. While such a signal is aggressively pursued by experiments around the world, recent Planck results have showed that this breakthrough is still out of reach, because of contamination from Galactic dust. To get to the primordial B-modes, we need to subtract polarized emission of magnetized interstellar dust with high accuracy. A critical piece of this puzzle is the 3D structure of the magnetic field threading dust clouds, which cannot be accessed through microwave observations alone, since they record integrated emission along the line of sight. Instead, observations of a large number of stars at known distances in optical polarization, tracing the same CMB-obscuring dust, can map the magnetic field between them. The Gaia mission is measuring distances to a billion stars, providing an opportunity to produce, the first-ever tomographic map of the Galactic magnetic field, using optical polarization of starlight. Such a map would not only boost CMB polarization foreground removal, but it would also have a profound impact in a wide range of astrophysical research, including interstellar medium physics, high-energy astrophysics, and galactic evolution. Taking advantage of our privately-funded, novel-technology, high-accuracy WALOP optopolarimeters currently under construction, we propose an ambitious optopolarimetric program of unprecedented scale that can meet this challenge: a survey of both northern and southern Galactic polar regions targeted by CMB experiments, covering >10,000 square degrees, which will measure linear optical polarization at 0.2% accuracy of over 360 stars per square degree (over 3.5M stars, a 1000-fold increase over the state of the art), combining wide-field-optimized instruments and an extraordinary commitment of observing time by Skinakas Observatory and the South African Astronomical Observatory.

1 887 500 €

Start date: 2018-06-01, End date: 2023-05-31

Novel artificial materials (photonic crystals (PCs), negative index materials (NIMs), and plasmonics) enable the realization of innovative EM properties unattainable in naturally existing materials. These materials, called metamaterials (MMs), have been in the foreground of scientific interest in the last ten years. However, many serious obstacles must be overcome before the impressive possibilities of MMs, especially in the optical regime, become real applications. The present project combines NIMs, PCs, and aspects of plasmonics in a unified way in order to promote the development of functional MMs, and mainly functional optical MMs (OMMs). It identifies the main obstacles, proposes specific approaches to deal with them, and intends to study unexplored capabilities of OMMs. The project objectives are: (a) Design and realization of 3d OMMs, and achieve new metasurface designs applying Babinet’s principle. (b) Understanding and reducing the losses in OMM by incorporating gain and EM induced transparency (EIT). (c) Achieving highly efficient PC nanolasers and surface plasmons (SPs) lasers. (d) Use chiral MMs and SPs to reduce and manipulate Casimir forces, and (e) Using MMs, combined with nonlinear materials, for THz generation, and tunable response.(f)Calculate electron- phonon scattering and edge collisions in graphene and in graphene-based molecules. The unifying link in all these objectives is the endowment of photons with novel properties through imaginative use of EM-field / artificial-matter interactions. Some of these objectives seem almost certainly realizable; others are more risky but with higher reward if accomplished; some are directed towards new specific applications, while others explore new physical reality. The accomplishment of those objectives requires novel ideas, advanced computational techniques, nanofabrication approaches, and testing. The broad expertise of the PI and his team, and their pioneering contributions to NIMs, PCs, and plasmonics qualifies them for facing the challenges and ensuring the maximum possible success of the project.

2 100 000 €

Start date: 2013-03-01, End date: 2019-02-28

It is now widely recognized that a variety of major diseases, such as Alzheimer’s disease, Huntington’s disease, systemic amyloidosis, cystic fibrosis, type 2 diabetes etc., are characterized by a common molecular origin: the misfolding of specific proteins. These disorders have been termed protein misfolding diseases (PMDs) and the vast majority of them remain incurable. Here, I propose the development of a unified approach for the discovery of potential therapeutics against PMDs. I will generate engineered bacterial cells that function as a broadly applicable discovery platform for compounds that rescue the misfolding of PMD-associated proteins (MisPs). These compounds will be selected from libraries of drug-like molecules biosynthesized in engineered bacteria using a technology that allows the facile production of billions of different test molecules. These libraries will then be screened in the same bacterial cells that produce them and the rare molecules that rescue MisP misfolding effectively will be selected using an ultrahigh-throughput genetic screen. The effect of the selected compounds on MisP folding will then be evaluated by biochemical and biophysical methods, while their ability to inhibit MisP-induced pathogenicity will be tested in appropriate mammalian cell assays and in established animal models of the associated PMD. The molecules that rescue the misfolding of the target MisPs and antagonize their associated pathogenicity both in vitro and in vivo, will become drug candidates against the corresponding diseases. This procedure will be applied for different MisPs to identify potential therapeutics for four major PMDs: Huntington’s disease, cardiotoxic light chain amyloidosis, dialysis-related amyloidosis and retinitis pigmentosa. Successful realization of ProMiDis will provide invaluable therapeutic leads against major diseases and a unified framework for anti-PMD drug discovery.

1 972 000 €

Start date: 2019-03-01, End date: 2024-02-29

Predicting the electron and spin transport properties of organic crystals is a formidable theoretical challenge as these are determined both by the electronic structure of the individual molecules and by the morphology of the crystal. Quest's research program seeks at developing a fully quantitative theory for electron and spin transport in organic crystals, which does not rely on external parameters and can be applied to materials underpinning a multitude of applications, ranging from organic electronics, to spintronics, to energy. In particular we aim at combining state of the art density functional theory with advanced quantum transport methods and Monte Carlo simulations. We will then construct a hierarchical computational protocol enabling us to evaluate electron and spin transport across different length scales at finite temperature, including effects originating from external fields (electric and magnetic). Our developed tools will form a software package to be distributed freely to academia.

1 492 728 €

Start date: 2012-12-01, End date: 2018-11-30