Project acronym 0MSPIN
Project Spintronics based on relativistic phenomena in systems with zero magnetic moment
Researcher (PI) Tomáš Jungwirth
Host Institution (HI) FYZIKALNI USTAV AV CR V.V.I
Call Details Advanced Grant (AdG), PE3, ERC-2010-AdG_20100224
Summary The 0MSPIN project consists of an extensive integrated theoretical, experimental and device development programme of research opening a radical new approach to spintronics. Spintronics has the potential to supersede existing storage and memory applications, and to provide alternatives to current CMOS technology. Ferromagnetic matels used in all current spintronics applications may make it impractical to realise the full potential of spintronics. Metals are unsuitable for transistor and information processing applications, for opto-electronics, or for high-density integration. The 0MSPIN project aims to remove the major road-block holding back the development of spintronics in a radical way: removing the ferromagnetic component from key active parts or from the whole of the spintronic devices. This approach is based on exploiting the combination of exchange and spin-orbit coupling phenomena and material systems with zero macroscopic moment. The goal of the 0MSPIN is to provide a new paradigm by which spintronics can enter the realms of conventional semiconductors in both fundamental condensed matter research and in information technologies. In the central part of the proposal, the research towards this goal is embedded within a materials science project whose aim is to introduce into physics and microelectronics an entirely new class of semiconductors. 0MSPIN seeks to exploit three classes of material systems: (1) Antiferromagnetic bi-metallic 3d-5d alloys (e.g. Mn2Au). (2) Antiferromagnetic I-II-V semiconductors (e.g. LiMnAs). (3) Non-magnetic spin-orbit coupled semiconductors with injected spin-polarized currents (e.g. 2D III-V structures). Proof of concept devices operating at high temperatures will be fabricated to show-case new functionalities offered by zero-moment systems for sensing and memory applications, information processing, and opto-electronics technologies.
Summary
The 0MSPIN project consists of an extensive integrated theoretical, experimental and device development programme of research opening a radical new approach to spintronics. Spintronics has the potential to supersede existing storage and memory applications, and to provide alternatives to current CMOS technology. Ferromagnetic matels used in all current spintronics applications may make it impractical to realise the full potential of spintronics. Metals are unsuitable for transistor and information processing applications, for opto-electronics, or for high-density integration. The 0MSPIN project aims to remove the major road-block holding back the development of spintronics in a radical way: removing the ferromagnetic component from key active parts or from the whole of the spintronic devices. This approach is based on exploiting the combination of exchange and spin-orbit coupling phenomena and material systems with zero macroscopic moment. The goal of the 0MSPIN is to provide a new paradigm by which spintronics can enter the realms of conventional semiconductors in both fundamental condensed matter research and in information technologies. In the central part of the proposal, the research towards this goal is embedded within a materials science project whose aim is to introduce into physics and microelectronics an entirely new class of semiconductors. 0MSPIN seeks to exploit three classes of material systems: (1) Antiferromagnetic bi-metallic 3d-5d alloys (e.g. Mn2Au). (2) Antiferromagnetic I-II-V semiconductors (e.g. LiMnAs). (3) Non-magnetic spin-orbit coupled semiconductors with injected spin-polarized currents (e.g. 2D III-V structures). Proof of concept devices operating at high temperatures will be fabricated to show-case new functionalities offered by zero-moment systems for sensing and memory applications, information processing, and opto-electronics technologies.
Max ERC Funding
1 938 000 €
Duration
Start date: 2011-06-01, End date: 2016-05-31
Project acronym 3-TOP
Project Exploring the physics of 3-dimensional topological insulators
Researcher (PI) Laurens Wigbolt Molenkamp
Host Institution (HI) JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG
Call Details Advanced Grant (AdG), PE3, ERC-2010-AdG_20100224
Summary Topological insulators constitute a novel class of materials where the topological details of the bulk band structure induce a robust surface state on the edges of the material. While transport data for 2-dimensional topological insulators have recently become available, experiments on their 3-dimensional counterparts are mainly limited to photoelectron spectroscopy. At the same time, a plethora of interesting novel physical phenomena have been predicted to occur in such systems.
In this proposal, we sketch an approach to tackle the transport and magnetic properties of the surface states in these materials. This starts with high quality layer growth, using molecular beam epitaxy, of bulk layers of HgTe, Bi2Se3 and Bi2Te3, which are the prime candidates to show the novel physics expected in this field. The existence of the relevant surface states will be assessed spectroscopically, but from there on research will focus on fabricating and characterizing nanostructures designed to elucidate the transport and magnetic properties of the topological surfaces using electrical, optical and scanning probe techniques. Apart from a general characterization of the Dirac band structure of the surface states, research will focus on the predicted magnetic monopole-like response of the system to an electrical test charge. In addition, much effort will be devoted to contacting the surface state with superconducting and magnetic top layers, with the final aim of demonstrating Majorana fermion behavior. As a final benefit, growth of thin high quality thin Bi2Se3 or Bi2Te3 layers could allow for a demonstration of the (2-dimensional) quantum spin Hall effect at room temperature - offering a road map to dissipation-less transport for the semiconductor industry.
Summary
Topological insulators constitute a novel class of materials where the topological details of the bulk band structure induce a robust surface state on the edges of the material. While transport data for 2-dimensional topological insulators have recently become available, experiments on their 3-dimensional counterparts are mainly limited to photoelectron spectroscopy. At the same time, a plethora of interesting novel physical phenomena have been predicted to occur in such systems.
In this proposal, we sketch an approach to tackle the transport and magnetic properties of the surface states in these materials. This starts with high quality layer growth, using molecular beam epitaxy, of bulk layers of HgTe, Bi2Se3 and Bi2Te3, which are the prime candidates to show the novel physics expected in this field. The existence of the relevant surface states will be assessed spectroscopically, but from there on research will focus on fabricating and characterizing nanostructures designed to elucidate the transport and magnetic properties of the topological surfaces using electrical, optical and scanning probe techniques. Apart from a general characterization of the Dirac band structure of the surface states, research will focus on the predicted magnetic monopole-like response of the system to an electrical test charge. In addition, much effort will be devoted to contacting the surface state with superconducting and magnetic top layers, with the final aim of demonstrating Majorana fermion behavior. As a final benefit, growth of thin high quality thin Bi2Se3 or Bi2Te3 layers could allow for a demonstration of the (2-dimensional) quantum spin Hall effect at room temperature - offering a road map to dissipation-less transport for the semiconductor industry.
Max ERC Funding
2 419 590 €
Duration
Start date: 2011-04-01, End date: 2016-03-31
Project acronym AMPCAT
Project Self-Amplifying Stereodynamic Catalysts in Enantioselective Catalysis
Researcher (PI) Oliver Trapp
Host Institution (HI) RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
Call Details Starting Grant (StG), PE5, ERC-2010-StG_20091028
Summary Think about an enantioselective catalyst, which can switch its enantioselectivity and which can be imprinted and provides self-amplification by its own chiral reaction product. Think about a catalyst, which can be fine-tuned for efficient stereoselective synthesis of drugs and other materials, e.g. polymers.
Highly promising reactions such as enantioselective autocatalysis (Soai reaction) and chiral catalysts undergoing dynamic interconversions, e.g. BIPHEP ligands, are still not understood. Their application is very limited to a few compounds, which opens the field for novel investigations.
I propose the development of a smart or switchable chiral ligand undergoing dynamic interconversions. These catalysts will be tuned by their reaction product, and this leads to self-amplification of one of the stereoisomers. I propose a novel fundamental mechanism which has the potential to overcome the limitations of the Soai reaction, exploiting the full potential of enantioselective catalysis.
As representatives of enantioselective self-amplifying stereodynamic catalysts a novel class of diazirine based ligands will be developed, their interconversion barrier is tuneable between 80 and 130 kJ/mol. Specifically, following areas will be explored:
1. Investigation of the kinetics and thermodynamics of the Soai reaction as a model reaction by analysis of large sets of kinetic data.
2. Ligands with diaziridine moieties with flexible structure will be designed and investigated, to control the enantioselectivity.
3. Design of a ligand receptor group for product interaction to switch the chirality. Study of self-amplification in enantioselective processes.
4. Enantioselective hydrogenations, Diels-Alder reactions, epoxidations and reactions generating multiple stereocenters will be targeted.
Summary
Think about an enantioselective catalyst, which can switch its enantioselectivity and which can be imprinted and provides self-amplification by its own chiral reaction product. Think about a catalyst, which can be fine-tuned for efficient stereoselective synthesis of drugs and other materials, e.g. polymers.
Highly promising reactions such as enantioselective autocatalysis (Soai reaction) and chiral catalysts undergoing dynamic interconversions, e.g. BIPHEP ligands, are still not understood. Their application is very limited to a few compounds, which opens the field for novel investigations.
I propose the development of a smart or switchable chiral ligand undergoing dynamic interconversions. These catalysts will be tuned by their reaction product, and this leads to self-amplification of one of the stereoisomers. I propose a novel fundamental mechanism which has the potential to overcome the limitations of the Soai reaction, exploiting the full potential of enantioselective catalysis.
As representatives of enantioselective self-amplifying stereodynamic catalysts a novel class of diazirine based ligands will be developed, their interconversion barrier is tuneable between 80 and 130 kJ/mol. Specifically, following areas will be explored:
1. Investigation of the kinetics and thermodynamics of the Soai reaction as a model reaction by analysis of large sets of kinetic data.
2. Ligands with diaziridine moieties with flexible structure will be designed and investigated, to control the enantioselectivity.
3. Design of a ligand receptor group for product interaction to switch the chirality. Study of self-amplification in enantioselective processes.
4. Enantioselective hydrogenations, Diels-Alder reactions, epoxidations and reactions generating multiple stereocenters will be targeted.
Max ERC Funding
1 452 000 €
Duration
Start date: 2010-12-01, End date: 2016-05-31
Project acronym ANAMULTISCALE
Project Analysis of Multiscale Systems Driven by Functionals
Researcher (PI) Alexander Mielke
Host Institution (HI) FORSCHUNGSVERBUND BERLIN EV
Call Details Advanced Grant (AdG), PE1, ERC-2010-AdG_20100224
Summary Many complex phenomena in the sciences are described by nonlinear partial differential equations, the solutions of which exhibit oscillations and concentration effects on multiple temporal or spatial scales. Our aim is to use methods from applied analysis to contribute to the understanding of the interplay of effects on different scales. The central question is to determine those quantities on the microscale which are needed to for the correct description of the macroscopic evolution.
We aim to develop a mathematical framework for analyzing and modeling coupled systems with multiple scales. This will include Hamiltonian dynamics as well as different types of dissipation like gradient flows or rate-independent dynamics. The choice of models will be guided by specific applications in material modeling (e.g., thermoplasticity, pattern formation, porous media) and optoelectronics (pulse interaction, Maxwell-Bloch systems, semiconductors, quantum mechanics). The research will address mathematically fundamental issues like existence and stability of solutions but will mainly be devoted to the modeling of multiscale phenomena in evolution systems. We will focus on systems with geometric structures, where the dynamics is driven by functionals. Thus, we can go much beyond the classical theory of homogenization and singular perturbations. The novel features of our approach are
- the combination of different dynamical effects in one framework,
- the use of geometric and metric structures for coupled partial differential equations,
- the exploitation of Gamma-convergence for evolution systems driven by functionals.
Summary
Many complex phenomena in the sciences are described by nonlinear partial differential equations, the solutions of which exhibit oscillations and concentration effects on multiple temporal or spatial scales. Our aim is to use methods from applied analysis to contribute to the understanding of the interplay of effects on different scales. The central question is to determine those quantities on the microscale which are needed to for the correct description of the macroscopic evolution.
We aim to develop a mathematical framework for analyzing and modeling coupled systems with multiple scales. This will include Hamiltonian dynamics as well as different types of dissipation like gradient flows or rate-independent dynamics. The choice of models will be guided by specific applications in material modeling (e.g., thermoplasticity, pattern formation, porous media) and optoelectronics (pulse interaction, Maxwell-Bloch systems, semiconductors, quantum mechanics). The research will address mathematically fundamental issues like existence and stability of solutions but will mainly be devoted to the modeling of multiscale phenomena in evolution systems. We will focus on systems with geometric structures, where the dynamics is driven by functionals. Thus, we can go much beyond the classical theory of homogenization and singular perturbations. The novel features of our approach are
- the combination of different dynamical effects in one framework,
- the use of geometric and metric structures for coupled partial differential equations,
- the exploitation of Gamma-convergence for evolution systems driven by functionals.
Max ERC Funding
1 390 000 €
Duration
Start date: 2011-04-01, End date: 2017-03-31
Project acronym ANOPTSETCON
Project Analysis of optimal sets and optimal constants: old questions and new results
Researcher (PI) Aldo Pratelli
Host Institution (HI) FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN NUERNBERG
Call Details Starting Grant (StG), PE1, ERC-2010-StG_20091028
Summary The analysis of geometric and functional inequalities naturally leads to consider the extremal cases, thus
looking for optimal sets, or optimal functions, or optimal constants. The most classical examples are the (different versions of the) isoperimetric inequality and the Sobolev-like inequalities. Much is known about equality cases and best constants, but there are still many questions which seem quite natural but yet have no answer. For instance, it is not known, even in the 2-dimensional space, the answer of a question by Brezis: which set,
among those with a given volume, has the biggest Sobolev-Poincaré constant for p=1? This is a very natural problem, and it appears reasonable that the optimal set should be the ball, but this has never been proved. The interest in problems like this relies not only in the extreme simplicity of the questions and in their classical flavour, but also in the new ideas and techniques which are needed to provide the answers.
The main techniques that we aim to use are fine arguments of symmetrization, geometric constructions and tools from mass transportation (which is well known to be deeply connected with functional inequalities). These are the basic tools that we already used to reach, in last years, many results in a specific direction, namely the search of sharp quantitative inequalities. Our first result, together with Fusco and Maggi, showed what follows. Everybody knows that the set which minimizes the perimeter with given volume is the ball.
But is it true that a set which almost minimizes the perimeter must be close to a ball? The question had been posed in the 1920's and many partial result appeared in the years. In our paper (Ann. of Math., 2007) we proved the sharp result. Many other results of this kind were obtained in last two years.
Summary
The analysis of geometric and functional inequalities naturally leads to consider the extremal cases, thus
looking for optimal sets, or optimal functions, or optimal constants. The most classical examples are the (different versions of the) isoperimetric inequality and the Sobolev-like inequalities. Much is known about equality cases and best constants, but there are still many questions which seem quite natural but yet have no answer. For instance, it is not known, even in the 2-dimensional space, the answer of a question by Brezis: which set,
among those with a given volume, has the biggest Sobolev-Poincaré constant for p=1? This is a very natural problem, and it appears reasonable that the optimal set should be the ball, but this has never been proved. The interest in problems like this relies not only in the extreme simplicity of the questions and in their classical flavour, but also in the new ideas and techniques which are needed to provide the answers.
The main techniques that we aim to use are fine arguments of symmetrization, geometric constructions and tools from mass transportation (which is well known to be deeply connected with functional inequalities). These are the basic tools that we already used to reach, in last years, many results in a specific direction, namely the search of sharp quantitative inequalities. Our first result, together with Fusco and Maggi, showed what follows. Everybody knows that the set which minimizes the perimeter with given volume is the ball.
But is it true that a set which almost minimizes the perimeter must be close to a ball? The question had been posed in the 1920's and many partial result appeared in the years. In our paper (Ann. of Math., 2007) we proved the sharp result. Many other results of this kind were obtained in last two years.
Max ERC Funding
540 000 €
Duration
Start date: 2010-08-01, End date: 2015-07-31
Project acronym ANTHOS
Project Analytic Number Theory: Higher Order Structures
Researcher (PI) Valentin Blomer
Host Institution (HI) GEORG-AUGUST-UNIVERSITAT GOTTINGENSTIFTUNG OFFENTLICHEN RECHTS
Call Details Starting Grant (StG), PE1, ERC-2010-StG_20091028
Summary This is a proposal for research at the interface of analytic number theory, automorphic forms and algebraic geometry. Motivated by fundamental conjectures in number theory, classical problems will be investigated in higher order situations: general number fields, automorphic forms on higher rank groups, the arithmetic of algebraic varieties of higher degree. In particular, I want to focus on
- computation of moments of L-function of degree 3 and higher with applications to subconvexity and/or non-vanishing, as well as subconvexity for multiple L-functions;
- bounds for sup-norms of cusp forms on various spaces and equidistribution of Hecke correspondences;
- automorphic forms on higher rank groups and general number fields, in particular new bounds towards the Ramanujan conjecture;
- a proof of Manin's conjecture for a certain class of singular algebraic varieties.
The underlying methods are closely related; for example, rational points on algebraic varieties
will be counted by a multiple L-series technique.
Summary
This is a proposal for research at the interface of analytic number theory, automorphic forms and algebraic geometry. Motivated by fundamental conjectures in number theory, classical problems will be investigated in higher order situations: general number fields, automorphic forms on higher rank groups, the arithmetic of algebraic varieties of higher degree. In particular, I want to focus on
- computation of moments of L-function of degree 3 and higher with applications to subconvexity and/or non-vanishing, as well as subconvexity for multiple L-functions;
- bounds for sup-norms of cusp forms on various spaces and equidistribution of Hecke correspondences;
- automorphic forms on higher rank groups and general number fields, in particular new bounds towards the Ramanujan conjecture;
- a proof of Manin's conjecture for a certain class of singular algebraic varieties.
The underlying methods are closely related; for example, rational points on algebraic varieties
will be counted by a multiple L-series technique.
Max ERC Funding
1 004 000 €
Duration
Start date: 2010-10-01, End date: 2015-09-30
Project acronym ANTIBACTERIALS
Project Natural products and their cellular targets: A multidisciplinary strategy for antibacterial drug discovery
Researcher (PI) Stephan Axel Sieber
Host Institution (HI) TECHNISCHE UNIVERSITAET MUENCHEN
Call Details Starting Grant (StG), PE5, ERC-2010-StG_20091028
Summary After decades of successful treatment of bacterial infections with antibiotics, formerly treatable bacteria have developed drug resistance and consequently pose a major threat to public health. To address the urgent need for effective antibacterial drugs we will develop a streamlined chemical-biology platform that facilitates the consolidated identification and structural elucidation of natural products together with their dedicated cellular targets. This innovative concept overcomes several limitations of classical drug discovery processes by a chemical strategy that focuses on a directed isolation, enrichment and identification procedure for certain privileged natural product subclasses. This proposal consists of four specific aims: 1) synthesizing enzyme active site mimetics that capture protein reactive natural products out of complex natural sources, 2) designing natural product based probes to identify their cellular targets by a method called activity based protein profiling , 3) developing a traceless photocrosslinking strategy for the target identification of selected non-reactive natural products, and 4) application of all probes to identify novel enzyme activities linked to viability, resistance and pathogenesis. Moreover, the compounds will be used to monitor the infection process during invasion into eukaryotic cells and will reveal host specific targets that promote and support bacterial pathogenesis. Inhibition of these targets is a novel and so far neglected approach in the treatment of infectious diseases. We anticipate that these studies will provide a powerful pharmacological platform for the development of potent natural product derived antibacterial agents directed toward novel therapeutic targets.
Summary
After decades of successful treatment of bacterial infections with antibiotics, formerly treatable bacteria have developed drug resistance and consequently pose a major threat to public health. To address the urgent need for effective antibacterial drugs we will develop a streamlined chemical-biology platform that facilitates the consolidated identification and structural elucidation of natural products together with their dedicated cellular targets. This innovative concept overcomes several limitations of classical drug discovery processes by a chemical strategy that focuses on a directed isolation, enrichment and identification procedure for certain privileged natural product subclasses. This proposal consists of four specific aims: 1) synthesizing enzyme active site mimetics that capture protein reactive natural products out of complex natural sources, 2) designing natural product based probes to identify their cellular targets by a method called activity based protein profiling , 3) developing a traceless photocrosslinking strategy for the target identification of selected non-reactive natural products, and 4) application of all probes to identify novel enzyme activities linked to viability, resistance and pathogenesis. Moreover, the compounds will be used to monitor the infection process during invasion into eukaryotic cells and will reveal host specific targets that promote and support bacterial pathogenesis. Inhibition of these targets is a novel and so far neglected approach in the treatment of infectious diseases. We anticipate that these studies will provide a powerful pharmacological platform for the development of potent natural product derived antibacterial agents directed toward novel therapeutic targets.
Max ERC Funding
1 500 000 €
Duration
Start date: 2010-11-01, End date: 2015-10-31
Project acronym APPARENT
Project Transition to parenthood: International and national studies of norms and gender division of work at the life course transition to parenthood
Researcher (PI) Daniela Grunow
Host Institution (HI) JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN
Call Details Starting Grant (StG), SH2, ERC-2010-StG_20091209
Summary The project is the first comprehensive study to assess contemporary parenting norms and practices and their diffusion. The project develops a comparative framework to study prevalent motherhood and fatherhood norms, images, identities and behaviour in current societies. The project will focus on how parenting roles are constructed by professionals, welfare states, and popular media, and will assess how cultural and institutional norms and images are perceived and realized by expecting and new parents.
In 4 subprojects this study investigates 1) How standards of 'good' mothering and fathering are perceived, shaped and disseminated by professionals (gynaecologists, midwives, family councils); 2) How welfare states, labour markets and family policies target at mothers and fathers roles as earners and care givers, and how this has changed in recent decades; 3) How images of mothers and fathers roles have been portrayed in print media from 1980 until 2010; 4) How (expecting) mothers and fathers perceive, embody and represent parenting norms and images in their own work and family roles; 5) How new parents divide paid and unpaid work and how these divisions shape career patterns over the life course; 6) How these patterns differ cross-nationally. The international collaboration includes Sweden, the Netherlands, Germany, Italy, the Czech Republic, and Poland.
The aim of this project is to develop a contemporary sociology of adult sex roles and parenting norms: A theory of the social creation of parenting norms and a comprehensive framework to study empirically the change of men's and women's roles, identities and practices as earners and care givers in the early phase of family formation.
By combining expert interviews, policy analysis and content analysis of print media with analyses of qualitative and quantitative data on (nascent) parents, the project will address the diverse layers associated with changing gender roles and parenting norms over the adult life course.
Summary
The project is the first comprehensive study to assess contemporary parenting norms and practices and their diffusion. The project develops a comparative framework to study prevalent motherhood and fatherhood norms, images, identities and behaviour in current societies. The project will focus on how parenting roles are constructed by professionals, welfare states, and popular media, and will assess how cultural and institutional norms and images are perceived and realized by expecting and new parents.
In 4 subprojects this study investigates 1) How standards of 'good' mothering and fathering are perceived, shaped and disseminated by professionals (gynaecologists, midwives, family councils); 2) How welfare states, labour markets and family policies target at mothers and fathers roles as earners and care givers, and how this has changed in recent decades; 3) How images of mothers and fathers roles have been portrayed in print media from 1980 until 2010; 4) How (expecting) mothers and fathers perceive, embody and represent parenting norms and images in their own work and family roles; 5) How new parents divide paid and unpaid work and how these divisions shape career patterns over the life course; 6) How these patterns differ cross-nationally. The international collaboration includes Sweden, the Netherlands, Germany, Italy, the Czech Republic, and Poland.
The aim of this project is to develop a contemporary sociology of adult sex roles and parenting norms: A theory of the social creation of parenting norms and a comprehensive framework to study empirically the change of men's and women's roles, identities and practices as earners and care givers in the early phase of family formation.
By combining expert interviews, policy analysis and content analysis of print media with analyses of qualitative and quantitative data on (nascent) parents, the project will address the diverse layers associated with changing gender roles and parenting norms over the adult life course.
Max ERC Funding
1 393 751 €
Duration
Start date: 2011-01-01, End date: 2016-12-31
Project acronym ARCID
Project The Role of Arl Proteins in Retinal and other Ciliary Diseases
Researcher (PI) Alfred Wittinghofer
Host Institution (HI) MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Call Details Advanced Grant (AdG), LS1, ERC-2010-AdG_20100317
Summary Arl (Arf-like) proteins, GTP-binding proteins of the Ras superfamily, are molecular switches that cycle between a GDP-bound inactive and GTP-bound active state. There are 16 members of the Arl subfamily in the human genome whose basic mechanistic function is unknown. The interactome of Arl2/3 includes proteins involved in retinopathies and other ciliary diseases such as Leber¿s Congenital Amaurosis (LCA) and kidney diseases such as nephronophthisis. Arl6 has been found mutated in Bardet Biedl Syndrome, another pleiotropic ciliary disease. In the proposed interdisciplinary project I want to explore the function of the protein network of Arl2/3 and Arl6 by a combination of biochemical, biophysical and structural methods and use the knowledge obtained to probe their function in live cells. As with other subfamily proteins of the Ras superfamily which have been found to mediate similar biological functions I want to derive a basic understanding of the function of Arl proteins and how it relates to the development and function of the ciliary organelle and how they contribute to ciliary diseases. The molecules in the focus of the project are: the GTP-binding proteins Arl2, 3, 6; RP2, an Arl3GAP mutated in Retinitis pigmentosa; Regulators of Arl2 and 3; PDE¿ and HRG4, effectors of Arl2/3, which bind lipidated proteins; RPGR, mutated in Retinitis pigmentosa, an interactor of PDE¿; RPGRIP and RPGRIPL, interactors of RPGR mutated in LCA and other ciliopathies; Nephrocystin, mutated in nephronophthisis, an interactor of RPGRIP and Arl6, mutated in Bardet Biedl Syndrome, and the BBS complex. The working hypothesis is that Arl protein network(s) mediate ciliary transport processes and that the GTP switch cycle of Arl proteins is an important element of regulation of these processes.
Summary
Arl (Arf-like) proteins, GTP-binding proteins of the Ras superfamily, are molecular switches that cycle between a GDP-bound inactive and GTP-bound active state. There are 16 members of the Arl subfamily in the human genome whose basic mechanistic function is unknown. The interactome of Arl2/3 includes proteins involved in retinopathies and other ciliary diseases such as Leber¿s Congenital Amaurosis (LCA) and kidney diseases such as nephronophthisis. Arl6 has been found mutated in Bardet Biedl Syndrome, another pleiotropic ciliary disease. In the proposed interdisciplinary project I want to explore the function of the protein network of Arl2/3 and Arl6 by a combination of biochemical, biophysical and structural methods and use the knowledge obtained to probe their function in live cells. As with other subfamily proteins of the Ras superfamily which have been found to mediate similar biological functions I want to derive a basic understanding of the function of Arl proteins and how it relates to the development and function of the ciliary organelle and how they contribute to ciliary diseases. The molecules in the focus of the project are: the GTP-binding proteins Arl2, 3, 6; RP2, an Arl3GAP mutated in Retinitis pigmentosa; Regulators of Arl2 and 3; PDE¿ and HRG4, effectors of Arl2/3, which bind lipidated proteins; RPGR, mutated in Retinitis pigmentosa, an interactor of PDE¿; RPGRIP and RPGRIPL, interactors of RPGR mutated in LCA and other ciliopathies; Nephrocystin, mutated in nephronophthisis, an interactor of RPGRIP and Arl6, mutated in Bardet Biedl Syndrome, and the BBS complex. The working hypothesis is that Arl protein network(s) mediate ciliary transport processes and that the GTP switch cycle of Arl proteins is an important element of regulation of these processes.
Max ERC Funding
2 434 400 €
Duration
Start date: 2011-04-01, End date: 2016-03-31
Project acronym ARMOS
Project Advanced multifunctional Reactors for green Mobility and Solar fuels
Researcher (PI) Athanasios Konstandopoulos
Host Institution (HI) ETHNIKO KENTRO EREVNAS KAI TECHNOLOGIKIS ANAPTYXIS
Call Details Advanced Grant (AdG), PE8, ERC-2010-AdG_20100224
Summary Green Mobility requires an integrated approach to the chain fuel/engine/emissions. The present project aims at ground breaking advances in the area of Green Mobility by (a) enabling the production of affordable, carbon-neutral, clean, solar fuels using exclusively renewable/recyclable raw materials, namely solar energy, water and captured Carbon Dioxide from combustion power plants (b) developing a highly compact, multifunctional reactor, able to eliminate gaseous and particulate emissions from the exhaust of engines operated on such clean fuels.
The overall research approach will be based on material science, engineering and simulation technology developed by the PI over the past 20 years in the area of Diesel Emission Control Reactors, which will be further extended and cross-fertilized in the area of Solar Thermochemical Reactors, an emerging discipline of high importance for sustainable development, where the PI’s research group has already made significant contributions, and received the 2006 European Commission’s Descartes Prize for the development of the first ever solar reactor, holding the potential to produce on a large scale, pure renewable Hydrogen from the thermochemical splitting of water, also known as the HYDROSOL technology.
Summary
Green Mobility requires an integrated approach to the chain fuel/engine/emissions. The present project aims at ground breaking advances in the area of Green Mobility by (a) enabling the production of affordable, carbon-neutral, clean, solar fuels using exclusively renewable/recyclable raw materials, namely solar energy, water and captured Carbon Dioxide from combustion power plants (b) developing a highly compact, multifunctional reactor, able to eliminate gaseous and particulate emissions from the exhaust of engines operated on such clean fuels.
The overall research approach will be based on material science, engineering and simulation technology developed by the PI over the past 20 years in the area of Diesel Emission Control Reactors, which will be further extended and cross-fertilized in the area of Solar Thermochemical Reactors, an emerging discipline of high importance for sustainable development, where the PI’s research group has already made significant contributions, and received the 2006 European Commission’s Descartes Prize for the development of the first ever solar reactor, holding the potential to produce on a large scale, pure renewable Hydrogen from the thermochemical splitting of water, also known as the HYDROSOL technology.
Max ERC Funding
1 750 000 €
Duration
Start date: 2011-02-01, End date: 2017-01-31
