ERC FUNDED PROJECTS

"Understanding how organisms regulate size is one of the most fascinating open questions in biology. The aim of the AMAIZE project is to unravel how growth of maize leaves is controlled. Maize leaf development offers great opportunities to study the dynamics of growth regulatory networks, essentially because leaf development is a linear system with cell division at the leaf basis followed by cell expansion and maturation. Furthermore, the growth zone is relatively large allowing easy access of tissues at different positions. Four different perturbations of maize leaf size will be analyzed with cellular resolution: wild-type and plants having larger leaves (as a consequence of GA20OX1 overexpression), both grown under either well-watered or mild drought conditions. Firstly, a 3D cellular map of the growth zone of the fourth leaf will be made. RNA-SEQ of three different tissues (adaxial- and abaxial epidermis; mesophyll) obtained by laser dissection with an interval of 2.5 mm along the growth zone will allow for the analysis of the transcriptome with high resolution. Additionally, the composition of fifty selected growth regulatory protein complexes and DNA targets of transcription factors will be determined with an interval of 5 mm along the growth zone. Computational methods will be used to construct comprehensive integrative maps of the cellular and molecular processes occurring along the growth zone. Finally, selected regulatory nodes of the growth regulatory networks will be further functionally analyzed using a transactivation system in maize. AMAIZE opens up new perspectives for the identification of optimal growth regulatory networks that can be selected for by advanced breeding or for which more robust variants (e.g. reduced susceptibility to drought) can be obtained through genetic engineering. The ability to improve the growth of maize and in analogy other cereals could have a high impact in providing food security"

2 418 429 €

Start date: 2014-02-01, End date: 2019-01-31

"With the ground-breaking discovery of a new, Higgs-like boson on July 4th, 2012, by the CMS and ATLAS collaborations at CERN, a new era of particle physics has begun. The discovery is the first step in answering an unsolved problem in particle physics, the question how fundamental bosons and fermions acquire their mass. One of the major goals in collider physics in the next few years will be the deeper insight into the nature of the new particle, its connection to the known fundamental particles and possible extensions beyond the standard model (SM) of particle physics. My project aims at a particular interesting field to study, the relation of the new particle with the heaviest known elementary particle, the top quark. I aim to develop new, innovative techniques and beyond state-of-the-art methods to extract the Yukawa coupling between the top quark and the Higgs boson, which is expected to be of the order of one - much higher than that of any other quark. I will analyse the only process where the top-Higgs Yukawa coupling can be measured, in associated production of top quark pairs and a Higgs boson. The Higgs boson mainly decays into a pair of b-quarks. This is one of the most challenging channels at the LHC, as huge background processes from gluon splitting contribute. In particular, I will develop and study color flow variables, which provide a unique, powerful technique to distinguish color singlet Higgs bosons from the main background, color octet gluons. The ultimate goal of the project is the first measurement of the top-Higgs Yukawa coupling and its confrontation with SM and beyond SM Higgs boson models, resulting in an unprecedented insight into the fundamental laws of nature. The LHC will soon reach a new energy frontier of 13 TeV starting in 2014. This new environment will provide never seen opportunities to study hints of new physics and precisely measure properties of the newly found particle. This sets the stage for the project."

1 163 755 €

Start date: 2014-02-01, End date: 2019-01-31

Ego-media: The impact of new media on forms and practices of self-presentation This project aims to study the impact of new media on autobiographical narratives: an impact increasing as habits and practices of self-presentation evolve rapidly in response to constantly fast-changing technology. It will analyse the range of ways in which autobiographical forms and discursive practices are being transformed at the frontier of technological change; then consider the implications of the new forms and practices for such notions as autobiography, selfhood, subjectivity, individuality, self-intelligibility, agency, creativity, privacy, and sociability. Based in the interdisciplinary Centre for Life-Writing Research in the School of Arts and Humanities at King’s College London, it will combine a humanistic, life-writing theory approach with an interdisciplinary methodology, in collaboration with researchers from Sociolinguistics, Culture Media and Creative Industries, Digital Humanities, Medical Humanities, Psychiatry, War Studies, and Education. Keywords: Life-writing, Self-Presentation, Autobiography, Subjectivity, Agency, New Media, Social Media, Immediacy, Discourse, Digital Narratives, Internet, Web 2.0

2 206 994 €

Start date: 2014-05-01, End date: 2019-04-30

"The term ""German operetta"" in the project title embraces twentieth-century operettas originating in both Austria and Germany. These enjoyed remarkable success in London and New York during 1907–1937, and, without deeper knowledge of them and their audience reception, we are sadly lacking in our understanding of the cultural mainstream in early twentieth-century Austria, Germany, the UK, and USA. Surprisingly, there has been no rigorous scholarly study of the cultural transfer of these German operettas to Britain and the USA, despite its taking place in a period that can be demarcated clearly. Academic attention has focused, instead, on America’s influence on European stage works. After Lehár’s Die lustige Witwe was produced to great acclaim in London and New York in 1907, the public appetite for German operetta grew rapidly in these cities. Although the First World War brought a temporary diminution of opportunities for new productions, there was an enthusiastic renewal of interest in the 1920s, and operettas from the theatres of Berlin were regularly adapted for the West End and Broadway. This project investigates the changes made for the London and New York productions in the context of cultural and social issues of the period, examining audience expectations, aspirations, and anxieties, and the social, cultural, and moral values of the times in which these works were created. It investigates how the operettas engage with modernity, innovative technology, social change, and cultural difference, seeking findings that will enhance knowledge of cultural transfer and transformation. Recently, there have been encouraging signs of a new flowering of interest, as the music enters the public domain free from copyright restrictions. New publications offering digitized reprints of the vocal scores, and historic recordings of radio broadcasts are becoming available. This project will create new knowledge that will help to stimulate both academic and market interests."

1 061 762 €

Start date: 2014-03-01, End date: 2019-02-28