Project acronym CAFYR
Project Constructing Age for Young Readers
Researcher (PI) Vanessa JOOSEN
Host Institution (HI) UNIVERSITEIT ANTWERPEN
Call Details Starting Grant (StG), SH5, ERC-2018-STG
Summary Constructing Age for Young Readers (CAFYR)
CAFYR starts from the observations that Europe has recently witnessed a few pertinent crises in intergenerational tension, that age norms and ageism frequently go unchecked and that they are part of children’s socialization. It aims at developing pioneering research for understanding how age is constructed in cultural products. CAFYR focuses on fiction for young readers as a discourse that often naturalizes age norms as part of an engaging story and that is endorsed in educational contexts for contributing to children’s literacy, social and cultural development. The effect of three factors on the construction of age in children’s books is studied: the age of the author, the age of the intended reader, and the age of the real reader.
CAFYR aims to lay bare whether and how the age and aging process of children’s authors affect their construction of the life stages in their works. It will show how various crosswriters shape the stages in life differently for young and adult readers. It considers the age of young readers as varied in its own right, and investigates how age is constructed differently for children of different ages, from preschoolers to adolescents. Finally, it brings together readers of various stages in the life course in a reception study that will help understand how real readers construct age, during the reading process and in dialogue with each other. CAFYR also aims to break new theoretical and methodological ground. It offers an interdisciplinary approach that enriches children’s literature research with concepts and theories from age studies. It combines close reading strategies with distant reading and tools developed for digital text analysis. It provides a platform to people of different stages in life, contributing to their awareness about age, and facilitating and investigating dialogues about age, with the aim of ultimately fostering them more.
Summary
Constructing Age for Young Readers (CAFYR)
CAFYR starts from the observations that Europe has recently witnessed a few pertinent crises in intergenerational tension, that age norms and ageism frequently go unchecked and that they are part of children’s socialization. It aims at developing pioneering research for understanding how age is constructed in cultural products. CAFYR focuses on fiction for young readers as a discourse that often naturalizes age norms as part of an engaging story and that is endorsed in educational contexts for contributing to children’s literacy, social and cultural development. The effect of three factors on the construction of age in children’s books is studied: the age of the author, the age of the intended reader, and the age of the real reader.
CAFYR aims to lay bare whether and how the age and aging process of children’s authors affect their construction of the life stages in their works. It will show how various crosswriters shape the stages in life differently for young and adult readers. It considers the age of young readers as varied in its own right, and investigates how age is constructed differently for children of different ages, from preschoolers to adolescents. Finally, it brings together readers of various stages in the life course in a reception study that will help understand how real readers construct age, during the reading process and in dialogue with each other. CAFYR also aims to break new theoretical and methodological ground. It offers an interdisciplinary approach that enriches children’s literature research with concepts and theories from age studies. It combines close reading strategies with distant reading and tools developed for digital text analysis. It provides a platform to people of different stages in life, contributing to their awareness about age, and facilitating and investigating dialogues about age, with the aim of ultimately fostering them more.
Max ERC Funding
1 400 885 €
Duration
Start date: 2019-02-01, End date: 2024-01-31
Project acronym CALLIOPE
Project voCAL articuLations Of Parliamentary Identity and Empire
Researcher (PI) Josephine HOEGAERTS
Host Institution (HI) HELSINGIN YLIOPISTO
Call Details Starting Grant (StG), SH5, ERC-2017-STG
Summary What did politicians sound like before they were on the radio and television? The fascination with politicians’ vocal characteristics and quirks is often connected to the rise of audio-visual media. But in the age of the printed press, political representatives also had to ‘speak well’ – without recourse to amplification.
Historians and linguists have provided sophisticated understandings of the discursive and aesthetic aspects of politicians’ language, but have largely ignored the importance of the acoustic character of their speech. CALLIOPE studies how vocal performances in parliament have influenced the course of political careers and political decision making in the 19th century. It shows how politicians’ voices helped to define the diverse identities they articulated. In viewing parliament through the lens of audibility, the project offers a new perspective on political representation by reframing how authority was embodied (through performances that were heard, rather than seen). It does so for the Second Chamber in Britain and France, and in dialogue with ‘colonial’ modes of speech in Kolkata and Algiers, which, we argue, exerted considerable influence on European vocal culture.
The project devises an innovative methodological approach to include the sound of the human voice in studies of the past that precede acoustic recording. Adapting methods developed in sound studies and combining them with the tools of political history, the project proposes a new way to analyse parliamentary reporting, while also drawing on a variety of sources that are rarely connected to the history of politics.
The main source material for the study comprise transcripts of parliamentary speech (official reports and renditions by journalists). However, the project also mobilizes educational, satirical and fictional sources to elucidate the convoluted processes that led to the cultivation, exertion, reception and evaluation of a voice ‘fit’ for nineteenth-century politics.
Summary
What did politicians sound like before they were on the radio and television? The fascination with politicians’ vocal characteristics and quirks is often connected to the rise of audio-visual media. But in the age of the printed press, political representatives also had to ‘speak well’ – without recourse to amplification.
Historians and linguists have provided sophisticated understandings of the discursive and aesthetic aspects of politicians’ language, but have largely ignored the importance of the acoustic character of their speech. CALLIOPE studies how vocal performances in parliament have influenced the course of political careers and political decision making in the 19th century. It shows how politicians’ voices helped to define the diverse identities they articulated. In viewing parliament through the lens of audibility, the project offers a new perspective on political representation by reframing how authority was embodied (through performances that were heard, rather than seen). It does so for the Second Chamber in Britain and France, and in dialogue with ‘colonial’ modes of speech in Kolkata and Algiers, which, we argue, exerted considerable influence on European vocal culture.
The project devises an innovative methodological approach to include the sound of the human voice in studies of the past that precede acoustic recording. Adapting methods developed in sound studies and combining them with the tools of political history, the project proposes a new way to analyse parliamentary reporting, while also drawing on a variety of sources that are rarely connected to the history of politics.
The main source material for the study comprise transcripts of parliamentary speech (official reports and renditions by journalists). However, the project also mobilizes educational, satirical and fictional sources to elucidate the convoluted processes that led to the cultivation, exertion, reception and evaluation of a voice ‘fit’ for nineteenth-century politics.
Max ERC Funding
1 499 905 €
Duration
Start date: 2018-03-01, End date: 2023-02-28
Project acronym CANCERSTEM
Project Stem cells in epithelial cancer initiation and growth
Researcher (PI) Cédric Blanpain
Host Institution (HI) UNIVERSITE LIBRE DE BRUXELLES
Call Details Starting Grant (StG), LS6, ERC-2007-StG
Summary Cancer is the result of a multi-step process requiring the accumulation of mutations in several genes. For most cancers, the target cells of oncogenic mutations are unknown. Adult stem cells (SCs) might be the initial target cells as they self-renew for extended periods of time, providing increased opportunity to accumulate the mutations required for cancer formation. Certain cancers contain cells characteristics of SC with high self-renewal capacities and the ability to reform the parental tumor upon transplantation. However, whether the initial oncogenic mutations arise in normal stem cells or in more differentiated cells that re-acquire stem cell-like properties remains to be determined. The demonstration that SCs are the target cells of the initial transforming events and that cancers contain cells with SC characteristics await the development of tools allowing for the isolation and characterization of normal adult SCs. In most epithelia from which cancers naturally arise, such tools are not yet available. We have recently developed novel methods to specifically mark and isolate multipotent epidermal slow-cycling SCs, making it now possible to determine the role of SC during epithelial cancer formation. In this project, we will use mice epidermis as a model to define the role of SC in epithelial cancer initiation and growth. Specifically, we will determine whether epithelial SCs are the initial target cells of oncogenic mutations during skin cancer formation, whether oncogenic mutations lead preferentially to skin cancer when they arise in SC rather than in more committed cells and whether cancer stem cells contribute to epithelial tumor growth and relapse after therapy.
Summary
Cancer is the result of a multi-step process requiring the accumulation of mutations in several genes. For most cancers, the target cells of oncogenic mutations are unknown. Adult stem cells (SCs) might be the initial target cells as they self-renew for extended periods of time, providing increased opportunity to accumulate the mutations required for cancer formation. Certain cancers contain cells characteristics of SC with high self-renewal capacities and the ability to reform the parental tumor upon transplantation. However, whether the initial oncogenic mutations arise in normal stem cells or in more differentiated cells that re-acquire stem cell-like properties remains to be determined. The demonstration that SCs are the target cells of the initial transforming events and that cancers contain cells with SC characteristics await the development of tools allowing for the isolation and characterization of normal adult SCs. In most epithelia from which cancers naturally arise, such tools are not yet available. We have recently developed novel methods to specifically mark and isolate multipotent epidermal slow-cycling SCs, making it now possible to determine the role of SC during epithelial cancer formation. In this project, we will use mice epidermis as a model to define the role of SC in epithelial cancer initiation and growth. Specifically, we will determine whether epithelial SCs are the initial target cells of oncogenic mutations during skin cancer formation, whether oncogenic mutations lead preferentially to skin cancer when they arise in SC rather than in more committed cells and whether cancer stem cells contribute to epithelial tumor growth and relapse after therapy.
Max ERC Funding
1 600 000 €
Duration
Start date: 2008-07-01, End date: 2013-12-31
Project acronym COMICS
Project Children in Comics: An Intercultural History from 1865 to Today
Researcher (PI) Maaheen AHMED
Host Institution (HI) UNIVERSITEIT GENT
Call Details Starting Grant (StG), SH5, ERC-2017-STG
Summary Owing to their visual essence and status as a popular, modern medium, comics – newspaper strips, comics magazines and graphic novels – provide valuable insight into the transformation of collective consciousness. This project advances the hypothesis that children in comics are distinctive embodiments of the complex experience of modernity, channeling and tempering modern anxieties and incarnating the freedom denied to adults. In testing this hypothesis, the project constructs the first intercultural history of children in European comics, tracing the changing conceptualizations of child protagonists in popular comics for both children and adults from the mid-19th century to the present. In doing so, it takes key points in European history as well as the history of comics into account.
Assembling a team of six multilingual researchers, the project uses an interdisciplinary methodology combining comics studies and childhood studies while also incorporating specific insights from cultural studies (history of family life, history of public life, history of the body, affect theory and scholarship on the carnivalesque). This enables the project to analyze the transposition of modern anxieties, conceptualizations of childishness, child-adult power relations, notions of liberty, visualizations of the body, family life, school and public life as well as the presence of affects such as nostalgia and happiness in comics starring children.
The project thus opens up a new field of research lying at the intersection of comics studies and childhood studies and illustrates its potential. In studying popular but often overlooked comics, the project provides crucial historical and analytical material that will shape future comics criticism and the fields associated with childhood studies. Furthermore, the project’s outreach activities will increase collective knowledge about comic strips, which form an important, increasingly visible part of cultural heritage.
Summary
Owing to their visual essence and status as a popular, modern medium, comics – newspaper strips, comics magazines and graphic novels – provide valuable insight into the transformation of collective consciousness. This project advances the hypothesis that children in comics are distinctive embodiments of the complex experience of modernity, channeling and tempering modern anxieties and incarnating the freedom denied to adults. In testing this hypothesis, the project constructs the first intercultural history of children in European comics, tracing the changing conceptualizations of child protagonists in popular comics for both children and adults from the mid-19th century to the present. In doing so, it takes key points in European history as well as the history of comics into account.
Assembling a team of six multilingual researchers, the project uses an interdisciplinary methodology combining comics studies and childhood studies while also incorporating specific insights from cultural studies (history of family life, history of public life, history of the body, affect theory and scholarship on the carnivalesque). This enables the project to analyze the transposition of modern anxieties, conceptualizations of childishness, child-adult power relations, notions of liberty, visualizations of the body, family life, school and public life as well as the presence of affects such as nostalgia and happiness in comics starring children.
The project thus opens up a new field of research lying at the intersection of comics studies and childhood studies and illustrates its potential. In studying popular but often overlooked comics, the project provides crucial historical and analytical material that will shape future comics criticism and the fields associated with childhood studies. Furthermore, the project’s outreach activities will increase collective knowledge about comic strips, which form an important, increasingly visible part of cultural heritage.
Max ERC Funding
1 452 500 €
Duration
Start date: 2018-10-01, End date: 2023-09-30
Project acronym CUTS
Project Creative Undoing and Textual Scholarship:
A Rapprochement between Genetic Criticism and Scholarly Editing
Researcher (PI) Dirk Van Hulle
Host Institution (HI) UNIVERSITEIT ANTWERPEN
Call Details Starting Grant (StG), SH5, ERC-2012-StG_20111124
Summary "In the past few decades, the disciplines of textual scholarship and genetic criticism have insisted on their respective differences. Nonetheless, a rapprochement would be mutually beneficial. The proposed research endeavours to innovate scholarly editing with the combined forces of these two disciplines. Since genetic criticism has objected to the subservient role of manuscript research in textual criticism, the proposed research suggests a reversal of roles: instead of employing manuscript research with a view to making an edition, an electronic edition can be designed in such a way that it becomes a tool for manuscript research and genetic criticism. The research hypothesis is that such a rapprochement can be achieved by means of an approach to textual variants that values creative undoing (ways of de-composing a text as an integral part of composition and literary invention) more than has hitherto been the case in textual scholarship. This change of outlook will be tested by means of the marginalia, notes and manuscripts of an author whose work is paradigmatic for genetic criticism: Samuel Beckett. His manuscripts will serve as a case study to determine the functions of creative undoing in the process of literary invention and its theoretical and practical implications for electronic scholarly editing and the genetic analysis of modern manuscripts. Extrapolating from this case study, the results are employed to tackle a topical issue in European textual scholarship. The envisaged rapprochement between the disciplines of genetic criticism and textual scholarship is the core of this proposal’s endeavour to advance the state of the art in these disciplines by giving shape to a new orientation within scholarly editing."
Summary
"In the past few decades, the disciplines of textual scholarship and genetic criticism have insisted on their respective differences. Nonetheless, a rapprochement would be mutually beneficial. The proposed research endeavours to innovate scholarly editing with the combined forces of these two disciplines. Since genetic criticism has objected to the subservient role of manuscript research in textual criticism, the proposed research suggests a reversal of roles: instead of employing manuscript research with a view to making an edition, an electronic edition can be designed in such a way that it becomes a tool for manuscript research and genetic criticism. The research hypothesis is that such a rapprochement can be achieved by means of an approach to textual variants that values creative undoing (ways of de-composing a text as an integral part of composition and literary invention) more than has hitherto been the case in textual scholarship. This change of outlook will be tested by means of the marginalia, notes and manuscripts of an author whose work is paradigmatic for genetic criticism: Samuel Beckett. His manuscripts will serve as a case study to determine the functions of creative undoing in the process of literary invention and its theoretical and practical implications for electronic scholarly editing and the genetic analysis of modern manuscripts. Extrapolating from this case study, the results are employed to tackle a topical issue in European textual scholarship. The envisaged rapprochement between the disciplines of genetic criticism and textual scholarship is the core of this proposal’s endeavour to advance the state of the art in these disciplines by giving shape to a new orientation within scholarly editing."
Max ERC Funding
1 147 740 €
Duration
Start date: 2013-01-01, End date: 2017-12-31
Project acronym DigitalMemories
Project We are all Ayotzinapa: The role of Digital Media in the Shaping of Transnational Memories on Disappearance
Researcher (PI) Silvana Mandolessi
Host Institution (HI) KATHOLIEKE UNIVERSITEIT LEUVEN
Call Details Starting Grant (StG), SH5, ERC-2015-STG
Summary The project seeks to study the role of digital media in the shaping of transnational memories on disappearance. It investigates a novel case that is in process of shaping: the disappearance of 43 students in Mexico in September 2014. The role of the new media in getting citizens’ attention and in marking a “turning point” was crucial to the upsurge of a counter-movement against the Mexican government and qualifies the event as significant for the transnational arena.
The groundbreaking aspect of the project consists in proposing a double approach:
a) a theoretical approach in which “disappearance” is considered as a particular crime that becomes a model for analyzing digital memory. Disappearance is a technology that produces a subject with a new ontological status: the disappeared are non-beings, because they are neither alive nor dead. This ontological status transgresses the clear boundaries separating life and death, past, present and future, materiality and immateriality, personal and collective spheres. “Digital memory”, i.e. a memory mediated by digital technology, is also determined by the transgression of the boundaries of given categories
b) a multidisciplinary approach situating Mexico´s case in a long transnational history of disappearance in the Hispanic World, including Argentina and Spain. This longer history seeks to compare disappearance as a mnemonic object developed in the global sphere –in social network sites as blogs, Facebook, Twitter and YouTube– in Mexico and the social performances and artistic representations –literature, photo exhibitions, and films– developed in Spain and Argentina.
The Mexican case represents a paradigm for the redefinition of the relationship between media and memory. The main output of the project will consist in constructing a theoretical model for analyzing digital mnemonic objects in the rise of networked social movements with a transnational scope.
Summary
The project seeks to study the role of digital media in the shaping of transnational memories on disappearance. It investigates a novel case that is in process of shaping: the disappearance of 43 students in Mexico in September 2014. The role of the new media in getting citizens’ attention and in marking a “turning point” was crucial to the upsurge of a counter-movement against the Mexican government and qualifies the event as significant for the transnational arena.
The groundbreaking aspect of the project consists in proposing a double approach:
a) a theoretical approach in which “disappearance” is considered as a particular crime that becomes a model for analyzing digital memory. Disappearance is a technology that produces a subject with a new ontological status: the disappeared are non-beings, because they are neither alive nor dead. This ontological status transgresses the clear boundaries separating life and death, past, present and future, materiality and immateriality, personal and collective spheres. “Digital memory”, i.e. a memory mediated by digital technology, is also determined by the transgression of the boundaries of given categories
b) a multidisciplinary approach situating Mexico´s case in a long transnational history of disappearance in the Hispanic World, including Argentina and Spain. This longer history seeks to compare disappearance as a mnemonic object developed in the global sphere –in social network sites as blogs, Facebook, Twitter and YouTube– in Mexico and the social performances and artistic representations –literature, photo exhibitions, and films– developed in Spain and Argentina.
The Mexican case represents a paradigm for the redefinition of the relationship between media and memory. The main output of the project will consist in constructing a theoretical model for analyzing digital mnemonic objects in the rise of networked social movements with a transnational scope.
Max ERC Funding
1 444 125 €
Duration
Start date: 2016-07-01, End date: 2021-06-30
Project acronym ENVIROIMMUNE
Project Environmental modulators of the immune cell balance in health and disease
Researcher (PI) Markus Kleinewietfeld
Host Institution (HI) VIB
Call Details Starting Grant (StG), LS6, ERC-2014-STG
Summary The incidence of autoimmune diseases in developed societies is increasing at high rates, but the underlying cause for this phenomenon has not been elucidated yet. Since the genetic architect remains considerably stable, this increase is likely associated with changes in the environment. Autoimmunity is linked to an imbalance of pro-inflammatory Th17 cells and anti-inflammatory Foxp3+ regulatory T cells (Treg). However, little is known regarding environmental factors that influence the Th17/Treg balance. We recently discovered that a sodium-rich diet severely exacerbates experimental autoimmune encephalomyelitis (EAE) through an increased induction of pathogenic Th17 cells. Surprisingly, our preliminary data indicate that high-salt conditions also significantly impair Treg function, resembling a phenotype observed in several human autoimmune diseases. In addition, we have evidence that a high-salt diet affects the gut microbiota, implicating possible indirect effects on immune cells in vivo. Based on these findings we hypothesize that excess dietary salt represents an environmental risk factor for autoimmune diseases by modulating the Th17/Treg balance by several direct and indirect mechanisms. To address this hypothesis we will 1) examine the underlying mechanisms of high-salt induced Treg dysfunction and effects on the Treg/Th17 balance by molecular and functional analysis in vitro and compare it to known risk variants of human autoimmune diseases, and 2) define direct and indirect effects of excess dietary salt on the Th17/Treg balance and autoimmunity in vivo and explore potential novel pathways for targeted interventions. Thus, the proposed study will uncover the impact of a newly discovered environmental modulator of the immune cell balance and will ultimately pave the way for new approaches in therapy and prevention of autoimmune diseases.
Summary
The incidence of autoimmune diseases in developed societies is increasing at high rates, but the underlying cause for this phenomenon has not been elucidated yet. Since the genetic architect remains considerably stable, this increase is likely associated with changes in the environment. Autoimmunity is linked to an imbalance of pro-inflammatory Th17 cells and anti-inflammatory Foxp3+ regulatory T cells (Treg). However, little is known regarding environmental factors that influence the Th17/Treg balance. We recently discovered that a sodium-rich diet severely exacerbates experimental autoimmune encephalomyelitis (EAE) through an increased induction of pathogenic Th17 cells. Surprisingly, our preliminary data indicate that high-salt conditions also significantly impair Treg function, resembling a phenotype observed in several human autoimmune diseases. In addition, we have evidence that a high-salt diet affects the gut microbiota, implicating possible indirect effects on immune cells in vivo. Based on these findings we hypothesize that excess dietary salt represents an environmental risk factor for autoimmune diseases by modulating the Th17/Treg balance by several direct and indirect mechanisms. To address this hypothesis we will 1) examine the underlying mechanisms of high-salt induced Treg dysfunction and effects on the Treg/Th17 balance by molecular and functional analysis in vitro and compare it to known risk variants of human autoimmune diseases, and 2) define direct and indirect effects of excess dietary salt on the Th17/Treg balance and autoimmunity in vivo and explore potential novel pathways for targeted interventions. Thus, the proposed study will uncover the impact of a newly discovered environmental modulator of the immune cell balance and will ultimately pave the way for new approaches in therapy and prevention of autoimmune diseases.
Max ERC Funding
1 499 041 €
Duration
Start date: 2015-08-01, End date: 2020-07-31
Project acronym ERSTRESS
Project Role of Endoplasmic Reticulum Stress in dendritic cells and immune-mediated lung diseases
Researcher (PI) Bart Lambrecht
Host Institution (HI) UNIVERSITEIT GENT
Call Details Starting Grant (StG), LS6, ERC-2010-StG_20091118
Summary My overall aim is to understand the physiologic and medical importance of lung dendritic cells (DC) and to define the suitability of inhibitors of their function for the treatment of inflammatory lung diseases like asthma and COPD.
Lung dendritic cells (DC) play crucial roles in the regulation of lung immunity. We still do not fully understand how they get activated in response to different types of environmental triggers like allergens, cigarette smoke and pathogens. Although recognition of conserved motifs by pattern recognition receptors on DCs could be a key event, these stimuli are also accompanied by accumulation of unfolded proteins in the endoplasmic reticulum (ER). Cells respond by mounting the unfolded protein response (UPR) that acts to ameliorate protein folding, but intersects with metabolism, induction of alarm signals and cellular suicide mechanisms. I hypothesize that the presence of unfolded proteins and ER stress in DCs is a crucial endogenous danger signal that is vital to understanding their biology and their involvement in inflammatory lung diseases.
My specific aims are to :
1.define the fine tuning of ER stress pathways in various lung DC subsets in health and disease
2. define the specific role of ER stress proteins XBP1, JIK and ORMDL3 in DCs
3. test if interfering with ER stress pathways alters the course of inflammatory lung disease
To approach these aims, I have developed mouse models of lung disease that are centered around lung DCs and where ER stress pathways can be genetically deleted. Using a combination of cell biological and immunological techniques I hope to achieve definitive answers as to how ER stress pathways regulate the function of DCs. Manipulation of ER stress pathways by drugs will have a major impact on very common diseases like diabetes, cardiovascular and neurodegenerative disease. Through the current proposal, I hope to extend this exciting field to lung biology.
Summary
My overall aim is to understand the physiologic and medical importance of lung dendritic cells (DC) and to define the suitability of inhibitors of their function for the treatment of inflammatory lung diseases like asthma and COPD.
Lung dendritic cells (DC) play crucial roles in the regulation of lung immunity. We still do not fully understand how they get activated in response to different types of environmental triggers like allergens, cigarette smoke and pathogens. Although recognition of conserved motifs by pattern recognition receptors on DCs could be a key event, these stimuli are also accompanied by accumulation of unfolded proteins in the endoplasmic reticulum (ER). Cells respond by mounting the unfolded protein response (UPR) that acts to ameliorate protein folding, but intersects with metabolism, induction of alarm signals and cellular suicide mechanisms. I hypothesize that the presence of unfolded proteins and ER stress in DCs is a crucial endogenous danger signal that is vital to understanding their biology and their involvement in inflammatory lung diseases.
My specific aims are to :
1.define the fine tuning of ER stress pathways in various lung DC subsets in health and disease
2. define the specific role of ER stress proteins XBP1, JIK and ORMDL3 in DCs
3. test if interfering with ER stress pathways alters the course of inflammatory lung disease
To approach these aims, I have developed mouse models of lung disease that are centered around lung DCs and where ER stress pathways can be genetically deleted. Using a combination of cell biological and immunological techniques I hope to achieve definitive answers as to how ER stress pathways regulate the function of DCs. Manipulation of ER stress pathways by drugs will have a major impact on very common diseases like diabetes, cardiovascular and neurodegenerative disease. Through the current proposal, I hope to extend this exciting field to lung biology.
Max ERC Funding
1 499 580 €
Duration
Start date: 2010-12-01, End date: 2015-11-30
Project acronym EUROHERIT
Project Legitimation of European cultural heritage and the dynamics of identity politics in the EU
Researcher (PI) Tuuli Kaarina Lähdesmäki
Host Institution (HI) JYVASKYLAN YLIOPISTO
Call Details Starting Grant (StG), SH5, ERC-2014-STG
Summary The problematic of transnational cultural heritage has become topical in a new way in Europe with the utilization of the idea of heritage for political purposes in the EU policy. Since the turn of the century, the EU has launched or jointly administered several initiatives focusing on fostering the idea of a common European cultural heritage. The heritage initiatives are the EU’s ‘technologies of power’ aiming to legitimate and justify certain political ideas and ideologies, such as European-wide identity politics and the cultural integration in Europe. However, the politics, discourses, and practices of heritage—and of transnational heritage in particular—are often intertwined with contentions over its symbolical and factual ownership, meanings, and uses. The project investigates the EU as a new heritage agent and its heritage politics as an attempt to create a new trans-European heritage regime in Europe: How does the EU aim to create common European cultural heritage in a politically shaking and culturally diversified Europe, and what kind of explicit and implicit politics are included in its aims? The project will focus on the legitimation processes of European cultural heritage at different territorial levels and the power relations formed in the processes between diverse agencies. The academia still lacks a comparative empirical investigation on the politics and practices of trans-European cultural heritage and the theoretical discussion on the role of the EU in them. The project aims to respond to this lack with a broad comparative empirical research including cases from various parts of Europe, penetrating different territorial scales (local, regional, national, and the EU), and theorizing cultural heritage from a multisectional perspective (stressing its concurrent use in diverse societal domains and discourses). The project participates in a critical discussion on the current identity and integration politics and policies in the EU and Europe.
Summary
The problematic of transnational cultural heritage has become topical in a new way in Europe with the utilization of the idea of heritage for political purposes in the EU policy. Since the turn of the century, the EU has launched or jointly administered several initiatives focusing on fostering the idea of a common European cultural heritage. The heritage initiatives are the EU’s ‘technologies of power’ aiming to legitimate and justify certain political ideas and ideologies, such as European-wide identity politics and the cultural integration in Europe. However, the politics, discourses, and practices of heritage—and of transnational heritage in particular—are often intertwined with contentions over its symbolical and factual ownership, meanings, and uses. The project investigates the EU as a new heritage agent and its heritage politics as an attempt to create a new trans-European heritage regime in Europe: How does the EU aim to create common European cultural heritage in a politically shaking and culturally diversified Europe, and what kind of explicit and implicit politics are included in its aims? The project will focus on the legitimation processes of European cultural heritage at different territorial levels and the power relations formed in the processes between diverse agencies. The academia still lacks a comparative empirical investigation on the politics and practices of trans-European cultural heritage and the theoretical discussion on the role of the EU in them. The project aims to respond to this lack with a broad comparative empirical research including cases from various parts of Europe, penetrating different territorial scales (local, regional, national, and the EU), and theorizing cultural heritage from a multisectional perspective (stressing its concurrent use in diverse societal domains and discourses). The project participates in a critical discussion on the current identity and integration politics and policies in the EU and Europe.
Max ERC Funding
1 339 755 €
Duration
Start date: 2015-09-01, End date: 2020-08-31
Project acronym EVWRIT
Project Everyday Writing in Graeco-Roman and Late Antique Egypt (I - VIII AD). A Socio-Semiotic Study of Communicative Variation
Researcher (PI) Klaas BENTEIN
Host Institution (HI) UNIVERSITEIT GENT
Call Details Starting Grant (StG), SH5, ERC-2017-STG
Summary This five-year project aims to generate a paradigm shift in the understanding of Graeco-Roman and Late Antique communication. Non-literary, ‘documentary’ texts from Ancient Egypt such as letters, petitions and contracts have provided and continue to provide a key witness for our knowledge of the administration, education, economy, etc. of Ancient Egypt. This project argues that since documentary texts represent originals, their external characteristics should also be brought into the interpretation: elements such as handwriting, linguistic register or writing material transmit indirect social messages concerning hierarchy, status, and power relations, and can therefore be considered ‘semiotic resources’. The project’s driving hypothesis is that communicative variation – variation that is functionally insignificant but socially significant (e.g. there are ~ there’s ~ it’s a lot of people) – enables the expression of social meaning. The main aim of this project is to analyse the nature of this communicative variation. To this end, a multidisciplinary team of six researchers (one PI, one post-doc, and four PhD’s) will apply recent insights form socio-semiotic and socio-linguistic theory to a corpus of Graeco-Roman and Late Antique documentary texts (I – VIII AD) by means of a three-level approach: (i) an open-access database of annotated documentary texts will be created; (ii) the ‘semiotic potential’ of the different semiotic resources that play a role in documentary writing will be analysed; (iii) the interrelationships between the different semiotic resources will be studied. The project will have a significant scientific impact: (i) it will be the first to offer a holistic perspective towards the ‘meaning’ of documentary texts; (ii) the digital tool will open up new ways to investigate Ancient texts; (iii) it will make an important contribution to current socio-semiotic and socio-linguistic research; (iv) it will provide new insights about humans as social beings.
Summary
This five-year project aims to generate a paradigm shift in the understanding of Graeco-Roman and Late Antique communication. Non-literary, ‘documentary’ texts from Ancient Egypt such as letters, petitions and contracts have provided and continue to provide a key witness for our knowledge of the administration, education, economy, etc. of Ancient Egypt. This project argues that since documentary texts represent originals, their external characteristics should also be brought into the interpretation: elements such as handwriting, linguistic register or writing material transmit indirect social messages concerning hierarchy, status, and power relations, and can therefore be considered ‘semiotic resources’. The project’s driving hypothesis is that communicative variation – variation that is functionally insignificant but socially significant (e.g. there are ~ there’s ~ it’s a lot of people) – enables the expression of social meaning. The main aim of this project is to analyse the nature of this communicative variation. To this end, a multidisciplinary team of six researchers (one PI, one post-doc, and four PhD’s) will apply recent insights form socio-semiotic and socio-linguistic theory to a corpus of Graeco-Roman and Late Antique documentary texts (I – VIII AD) by means of a three-level approach: (i) an open-access database of annotated documentary texts will be created; (ii) the ‘semiotic potential’ of the different semiotic resources that play a role in documentary writing will be analysed; (iii) the interrelationships between the different semiotic resources will be studied. The project will have a significant scientific impact: (i) it will be the first to offer a holistic perspective towards the ‘meaning’ of documentary texts; (ii) the digital tool will open up new ways to investigate Ancient texts; (iii) it will make an important contribution to current socio-semiotic and socio-linguistic research; (iv) it will provide new insights about humans as social beings.
Max ERC Funding
1 476 250 €
Duration
Start date: 2018-06-01, End date: 2023-05-31
