Project acronym 2STEPPARKIN
Project A novel two-step model for neurodegeneration in Parkinson’s disease
Researcher (PI) Emi Nagoshi
Host Institution (HI) UNIVERSITE DE GENEVE
Call Details Starting Grant (StG), LS5, ERC-2012-StG_20111109
Summary Parkinson’s disease (PD) is the second most common neurodegenerative disorder primarily caused by the progressive loss of dopaminergic (DA) neurons in the substantia nigra (SN). Despite the advances in gene discovery associated with PD, the knowledge of the PD pathogenesis is largely limited to the involvement of these genes in the generic cell death pathways, and why degeneration is specific to DA neurons and why the degeneration is progressive remain enigmatic. Broad goal of our work is therefore to elucidate the mechanisms underlying specific and progressive DA neuron degeneration in PD. Our new Drosophila model of PD ⎯Fer2 gene loss-of-function mutation⎯ is unusually well suited to address these questions. Fer2 mutants exhibit specific and progressive death of brain DA neurons as well as severe locomotor defects and short life span. Strikingly, the death of DA neuron is initiated in a small cluster of Fer2-expressing DA neurons and subsequently propagates to Fer2-negative DA neurons. We therefore propose a novel two-step model of the neurodegeneration in PD: primary cell death occurs in a specific subset of dopamindegic neurons that are genetically defined, and subsequently the failure of the neuronal connectivity triggers and propagates secondary cell death to remaining DA neurons. In this research, we will test this hypothesis and investigate the underlying molecular mechanisms. This will be the first study to examine circuit-dependency in DA neuron degeneration. Our approach will use a combination of non-biased genomic techniques and candidate-based screening, in addition to the powerful Drosophila genetic toolbox. Furthermore, to test this hypothesis beyond the Drosophila model, we will establish new mouse models of PD that exhibit progressive DA neuron degeneration. Outcome of this research will likely revolutionize the understanding of PD pathogenesis and open an avenue toward the discovery of effective therapy strategies against PD.
Summary
Parkinson’s disease (PD) is the second most common neurodegenerative disorder primarily caused by the progressive loss of dopaminergic (DA) neurons in the substantia nigra (SN). Despite the advances in gene discovery associated with PD, the knowledge of the PD pathogenesis is largely limited to the involvement of these genes in the generic cell death pathways, and why degeneration is specific to DA neurons and why the degeneration is progressive remain enigmatic. Broad goal of our work is therefore to elucidate the mechanisms underlying specific and progressive DA neuron degeneration in PD. Our new Drosophila model of PD ⎯Fer2 gene loss-of-function mutation⎯ is unusually well suited to address these questions. Fer2 mutants exhibit specific and progressive death of brain DA neurons as well as severe locomotor defects and short life span. Strikingly, the death of DA neuron is initiated in a small cluster of Fer2-expressing DA neurons and subsequently propagates to Fer2-negative DA neurons. We therefore propose a novel two-step model of the neurodegeneration in PD: primary cell death occurs in a specific subset of dopamindegic neurons that are genetically defined, and subsequently the failure of the neuronal connectivity triggers and propagates secondary cell death to remaining DA neurons. In this research, we will test this hypothesis and investigate the underlying molecular mechanisms. This will be the first study to examine circuit-dependency in DA neuron degeneration. Our approach will use a combination of non-biased genomic techniques and candidate-based screening, in addition to the powerful Drosophila genetic toolbox. Furthermore, to test this hypothesis beyond the Drosophila model, we will establish new mouse models of PD that exhibit progressive DA neuron degeneration. Outcome of this research will likely revolutionize the understanding of PD pathogenesis and open an avenue toward the discovery of effective therapy strategies against PD.
Max ERC Funding
1 518 960 €
Duration
Start date: 2013-06-01, End date: 2018-05-31
Project acronym ACROSSBORDERS
Project Across ancient borders and cultures: An Egyptian microcosm in Sudan during the 2nd millennium BC
Researcher (PI) Julia Budka
Host Institution (HI) LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Call Details Starting Grant (StG), SH6, ERC-2012-StG_20111124
Summary Pharaonic Egypt is commonly known for its pyramids and tomb treasures. The present knowledge of Egyptian everyday life and social structures derives mostly from mortuary records associated with the upper classes, whereas traces of ordinary life from domestic sites are generally disregarded. Settlement archaeology in Egypt and Nubia (Ancient North Sudan) is still in its infancy; it is timely to strenghten this field. Responsible for the pottery at three major settlement sites (Abydos and Elephantine in Egypt; Sai Island in Sudan), the PI is in a unique position to co-ordinate a research project on settlement patterns in Northeast Africa of the 2nd millennium BC based on the detailed analysis of material remains. The selected case studies situated across ancient and modern borders and of diverse environmental and cultural preconditions, show very similar archaeological remains. Up to now, no attempt has been made to explain this situation in detail.
The focus of the project is the well-preserved, only partially explored site of Sai Island, seemingly an Egyptian microcosm in New Kingdom Upper Nubia. Little time is left to conduct the requisite large-scale archaeology as Sai is endangered by the planned high dam of Dal. With the application of microarchaeology we will introduce an approach that is new in Egyptian settlement archaeology. Our interdisciplinary research will result in novel insights into (a) multifaceted lives on Sai at a micro-spatial level and (b) domestic life in 2nd millennium BC Egypt and Nubia from a macroscopic view. The present understanding of the political situation in Upper Nubia during the New Kingdom as based on written records will be significantly enlarged by the envisaged approach. Furthermore, in reconstructing Sai Island as “home away from home”, the project presents a showcase study of what we can learn about acculturation and adaptation from ancient cultures, in this case from the coexistence of Egyptians and Nubians
Summary
Pharaonic Egypt is commonly known for its pyramids and tomb treasures. The present knowledge of Egyptian everyday life and social structures derives mostly from mortuary records associated with the upper classes, whereas traces of ordinary life from domestic sites are generally disregarded. Settlement archaeology in Egypt and Nubia (Ancient North Sudan) is still in its infancy; it is timely to strenghten this field. Responsible for the pottery at three major settlement sites (Abydos and Elephantine in Egypt; Sai Island in Sudan), the PI is in a unique position to co-ordinate a research project on settlement patterns in Northeast Africa of the 2nd millennium BC based on the detailed analysis of material remains. The selected case studies situated across ancient and modern borders and of diverse environmental and cultural preconditions, show very similar archaeological remains. Up to now, no attempt has been made to explain this situation in detail.
The focus of the project is the well-preserved, only partially explored site of Sai Island, seemingly an Egyptian microcosm in New Kingdom Upper Nubia. Little time is left to conduct the requisite large-scale archaeology as Sai is endangered by the planned high dam of Dal. With the application of microarchaeology we will introduce an approach that is new in Egyptian settlement archaeology. Our interdisciplinary research will result in novel insights into (a) multifaceted lives on Sai at a micro-spatial level and (b) domestic life in 2nd millennium BC Egypt and Nubia from a macroscopic view. The present understanding of the political situation in Upper Nubia during the New Kingdom as based on written records will be significantly enlarged by the envisaged approach. Furthermore, in reconstructing Sai Island as “home away from home”, the project presents a showcase study of what we can learn about acculturation and adaptation from ancient cultures, in this case from the coexistence of Egyptians and Nubians
Max ERC Funding
1 497 460 €
Duration
Start date: 2012-12-01, End date: 2018-04-30
Project acronym ADAPT
Project The Adoption of New Technological Arrays in the Production of Broadcast Television
Researcher (PI) John Cyril Paget Ellis
Host Institution (HI) ROYAL HOLLOWAY AND BEDFORD NEW COLLEGE
Call Details Advanced Grant (AdG), SH5, ERC-2012-ADG_20120411
Summary "Since 1960, the television industry has undergone successive waves of technological change. Both the methods of programme making and the programmes themselves have changed substantially. The current opening of TV’s vast archives to public and academic use has emphasised the need to explain old programming to new users. Why particular programmes are like they are is not obvious to the contemporary viewer: the prevailing technologies imposed limits and enabled forms that have fallen into disuse. The project will examine the processes of change which gave rise to the particular dominant configurations of technologies for sound and image capture and processing, and some idea of the national and regional variants that existed. It will emphasise the capabilities of the machines in use rather than the process of their invention. The project therefore studies how the technologies of film and tape were implemented; how both broadcasters and individual filmers coped with the conflicting demands of the different machines at their disposal; how new ‘standard ways of doing things’ gradually emerged; and how all of this enabled desired changes in the resultant programmes. The project will produce an overall written account of the principal changes in the technologies in use in broadcast TV since 1960 to the near present. It will offer a theory of technological innovation, and a major case study in the adoption of digital workflow management in production for broadcasting: the so-called ‘tapeless environment’ which is currently being implemented in major organisations. It will offer two historical case studies: a longditudinal study of the evolution of tape-based sound recording and one of the rapid change from 16mm film cutting to digital editing, a process that took less than five years. Reconstructions of the process of working with particular technological arrays will be filmed and will be made available as explanatory material for any online archive of TV material ."
Summary
"Since 1960, the television industry has undergone successive waves of technological change. Both the methods of programme making and the programmes themselves have changed substantially. The current opening of TV’s vast archives to public and academic use has emphasised the need to explain old programming to new users. Why particular programmes are like they are is not obvious to the contemporary viewer: the prevailing technologies imposed limits and enabled forms that have fallen into disuse. The project will examine the processes of change which gave rise to the particular dominant configurations of technologies for sound and image capture and processing, and some idea of the national and regional variants that existed. It will emphasise the capabilities of the machines in use rather than the process of their invention. The project therefore studies how the technologies of film and tape were implemented; how both broadcasters and individual filmers coped with the conflicting demands of the different machines at their disposal; how new ‘standard ways of doing things’ gradually emerged; and how all of this enabled desired changes in the resultant programmes. The project will produce an overall written account of the principal changes in the technologies in use in broadcast TV since 1960 to the near present. It will offer a theory of technological innovation, and a major case study in the adoption of digital workflow management in production for broadcasting: the so-called ‘tapeless environment’ which is currently being implemented in major organisations. It will offer two historical case studies: a longditudinal study of the evolution of tape-based sound recording and one of the rapid change from 16mm film cutting to digital editing, a process that took less than five years. Reconstructions of the process of working with particular technological arrays will be filmed and will be made available as explanatory material for any online archive of TV material ."
Max ERC Funding
1 680 121 €
Duration
Start date: 2013-08-01, End date: 2018-07-31
Project acronym AgricUrb
Project The Agricultural Origins of Urban Civilization
Researcher (PI) Amy Marie Bogaard
Host Institution (HI) THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Call Details Starting Grant (StG), SH6, ERC-2012-StG_20111124
Summary The establishment of farming is a pivotal moment in human history, setting the stage for the emergence of class-based society and urbanization. Monolithic views of the nature and development of early agriculture, however, have prevented clear understanding of how exactly farming fuelled, shaped and sustained the emergence of complex societies. A breakthrough in archaeological approach is needed to determine the actual roles of farming in the emergence of social complexity. The methodology required must push beyond conventional interpretation of the most direct farming evidence – archaeobotanical remains of crops and associated arable weeds – to reconstruct not only what crops were grown, but also how, where and why farming was practised. Addressing these related aspects, in contexts ranging from early agricultural villages to some of the world’s earliest cities, would provide the key to unraveling the contribution of farming to the development of lasting social inequalities. The research proposed here takes a new interdisciplinary approach combining archaeobotany, plant stable isotope chemistry and functional plant ecology, building on groundwork laid in previous research by the applicant. These approaches will be applied to two relatively well researched areas, western Asia and Europe, where a series of sites that chart multiple pathways to early complex societies offer rich plant and other bioarchaeological assemblages. The proposed project will set a wholly new standard of insight into early farming and its relationship with early civilization, facilitating similar approaches in other parts of the world and the construction of comparative perspectives on the global significance of early agriculture in social development.
Summary
The establishment of farming is a pivotal moment in human history, setting the stage for the emergence of class-based society and urbanization. Monolithic views of the nature and development of early agriculture, however, have prevented clear understanding of how exactly farming fuelled, shaped and sustained the emergence of complex societies. A breakthrough in archaeological approach is needed to determine the actual roles of farming in the emergence of social complexity. The methodology required must push beyond conventional interpretation of the most direct farming evidence – archaeobotanical remains of crops and associated arable weeds – to reconstruct not only what crops were grown, but also how, where and why farming was practised. Addressing these related aspects, in contexts ranging from early agricultural villages to some of the world’s earliest cities, would provide the key to unraveling the contribution of farming to the development of lasting social inequalities. The research proposed here takes a new interdisciplinary approach combining archaeobotany, plant stable isotope chemistry and functional plant ecology, building on groundwork laid in previous research by the applicant. These approaches will be applied to two relatively well researched areas, western Asia and Europe, where a series of sites that chart multiple pathways to early complex societies offer rich plant and other bioarchaeological assemblages. The proposed project will set a wholly new standard of insight into early farming and its relationship with early civilization, facilitating similar approaches in other parts of the world and the construction of comparative perspectives on the global significance of early agriculture in social development.
Max ERC Funding
1 199 647 €
Duration
Start date: 2013-02-01, End date: 2017-01-31
Project acronym AMYLOID
Project Identification and modulation of pathogenic Amyloid beta-peptide species
Researcher (PI) Christian Haass
Host Institution (HI) LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Call Details Advanced Grant (AdG), LS5, ERC-2012-ADG_20120314
Summary The frequency of Alzheimer's disease (AD) will dramatically increase in the ageing western society during the next decades. Currently, about 18 million people suffer worldwide from AD. Since no cure is available, this devastating disorder represents one of the most challenging socio-economical problems of our future. As onset and progression of AD is triggered by the amyloid cascade, I will put particular attention on amyloid ß-peptide (Aß). The reason for this approach is, that even though 20 years ago the Aß generating processing pathway was identified (Haass et al., Nature 1992a & b), the identity of the Aß species, which initiate the deadly cascade is still unknown. I will first tackle this challenge by investigating if a novel and so far completely overlooked proteolytic processing pathway is involved in the generation of Aß species capable to initiate spreading of pathology and neurotoxicity. I will then search for modulating proteins, which could affect generation of pathological Aß species. This includes a genome-wide screen for modifiers of gamma-secretase, one of the proteases involved in Aß generation as well as a targeted search for RNA binding proteins capable to posttranscriptionally regulate beta- and alpha-secretase. In a disease-crossing approach, RNA binding proteins, which were recently found not only to be deposited in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis but also in many AD cases, will be investigated for their potential to modulate Aß aggregation and AD pathology. Modifiers and novel antibodies specifically recognizing neurotoxic Aß assemblies will be validated for their potential not only to prevent amyloid plaque formation, but also spreading of pathology as well as neurotoxicity. In vivo validations include studies in innovative zebrafish models, which allow life imaging of neuronal cell death, as well as the establishment of microPET amyloid imaging for longitudinal studies in individual animals.
Summary
The frequency of Alzheimer's disease (AD) will dramatically increase in the ageing western society during the next decades. Currently, about 18 million people suffer worldwide from AD. Since no cure is available, this devastating disorder represents one of the most challenging socio-economical problems of our future. As onset and progression of AD is triggered by the amyloid cascade, I will put particular attention on amyloid ß-peptide (Aß). The reason for this approach is, that even though 20 years ago the Aß generating processing pathway was identified (Haass et al., Nature 1992a & b), the identity of the Aß species, which initiate the deadly cascade is still unknown. I will first tackle this challenge by investigating if a novel and so far completely overlooked proteolytic processing pathway is involved in the generation of Aß species capable to initiate spreading of pathology and neurotoxicity. I will then search for modulating proteins, which could affect generation of pathological Aß species. This includes a genome-wide screen for modifiers of gamma-secretase, one of the proteases involved in Aß generation as well as a targeted search for RNA binding proteins capable to posttranscriptionally regulate beta- and alpha-secretase. In a disease-crossing approach, RNA binding proteins, which were recently found not only to be deposited in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis but also in many AD cases, will be investigated for their potential to modulate Aß aggregation and AD pathology. Modifiers and novel antibodies specifically recognizing neurotoxic Aß assemblies will be validated for their potential not only to prevent amyloid plaque formation, but also spreading of pathology as well as neurotoxicity. In vivo validations include studies in innovative zebrafish models, which allow life imaging of neuronal cell death, as well as the establishment of microPET amyloid imaging for longitudinal studies in individual animals.
Max ERC Funding
2 497 020 €
Duration
Start date: 2013-03-01, End date: 2018-02-28
Project acronym ANALYTICAL SOCIOLOGY
Project Analytical Sociology: Theoretical Developments and Empirical Research
Researcher (PI) Mats Peter Hedström
Host Institution (HI) LINKOPINGS UNIVERSITET
Call Details Advanced Grant (AdG), SH2, ERC-2012-ADG_20120411
Summary This proposal outlines a highly ambitious and path-breaking research program. Through a tightly integrated package of basic theoretical work, strategic empirical research projects, international workshops, and a large number of publications in leading journals, the research program seeks to move sociology in a more analytical direction.
One part of the research program focuses on the epistemological and methodological foundations of analytical sociology, an approach to sociological theory and research that currently receives considerable attention in the international scholarly community. This work will be organized around two core themes: (1) the principles of mechanism-based explanations and (2) the micro-macro link.
The empirical research analyzes in great detail the ethnic, gender, and socio-economic segregation of key interaction domains in Sweden using the approach of analytical sociology. The interaction domains focused upon are schools, workplaces and neighborhoods; domains where people spend a considerable part of their time, where much of the social interaction between people takes place, where identities are formed, and where important resources are distributed.
Large-scale longitudinal micro data on the entire Swedish population, unique longitudinal data on social networks within school classes, and various agent-based simulation techniques, are used to better understand the processes through which schools, workplaces and neighborhoods become segregated along various dimensions, how the domains interact with one another, and how the structure and extent of segregation affects diverse social and economic outcomes.
Summary
This proposal outlines a highly ambitious and path-breaking research program. Through a tightly integrated package of basic theoretical work, strategic empirical research projects, international workshops, and a large number of publications in leading journals, the research program seeks to move sociology in a more analytical direction.
One part of the research program focuses on the epistemological and methodological foundations of analytical sociology, an approach to sociological theory and research that currently receives considerable attention in the international scholarly community. This work will be organized around two core themes: (1) the principles of mechanism-based explanations and (2) the micro-macro link.
The empirical research analyzes in great detail the ethnic, gender, and socio-economic segregation of key interaction domains in Sweden using the approach of analytical sociology. The interaction domains focused upon are schools, workplaces and neighborhoods; domains where people spend a considerable part of their time, where much of the social interaction between people takes place, where identities are formed, and where important resources are distributed.
Large-scale longitudinal micro data on the entire Swedish population, unique longitudinal data on social networks within school classes, and various agent-based simulation techniques, are used to better understand the processes through which schools, workplaces and neighborhoods become segregated along various dimensions, how the domains interact with one another, and how the structure and extent of segregation affects diverse social and economic outcomes.
Max ERC Funding
1 745 098 €
Duration
Start date: 2013-03-01, End date: 2018-02-28
Project acronym AncNar
Project Experience and Teleology in Ancient Narrative
Researcher (PI) Jonas Grethlein
Host Institution (HI) RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
Call Details Starting Grant (StG), SH5, ERC-2012-StG_20111124
Summary The last two decades have seen fascinating attempts to establish new narratologies, basing narratology on cognitive science or coupling it with other approaches such as postcolonial studies. While appreciating that these attempts have raised questions beyond the limits of structuralist narratology, critics have noted that by doing so they tend to abandon narratology’s strength, that is its analytical tools. In many cases, narratology has become a label that is as empty as it is fashionable. The project as outlined here, on the other hand, develops a new approach that combines the analytical arsenal of structuralist narratology with a phenomenological take on time in order to provide new answers as to the question of narrative’s function. By exploring the tension between experience and teleology in ancient literature, it sets out to demonstrate how narrative serves as a mode of coming to grips with time. Besides offering a new narratology that cross-fertilizes the strengths of different disciplines and pioneering a new approach to ancient literature, the project will steer the current debate on experience and presence into a new direction across disciplines in the humanities.
Summary
The last two decades have seen fascinating attempts to establish new narratologies, basing narratology on cognitive science or coupling it with other approaches such as postcolonial studies. While appreciating that these attempts have raised questions beyond the limits of structuralist narratology, critics have noted that by doing so they tend to abandon narratology’s strength, that is its analytical tools. In many cases, narratology has become a label that is as empty as it is fashionable. The project as outlined here, on the other hand, develops a new approach that combines the analytical arsenal of structuralist narratology with a phenomenological take on time in order to provide new answers as to the question of narrative’s function. By exploring the tension between experience and teleology in ancient literature, it sets out to demonstrate how narrative serves as a mode of coming to grips with time. Besides offering a new narratology that cross-fertilizes the strengths of different disciplines and pioneering a new approach to ancient literature, the project will steer the current debate on experience and presence into a new direction across disciplines in the humanities.
Max ERC Funding
1 383 840 €
Duration
Start date: 2013-02-01, End date: 2018-01-31
Project acronym APMPAL
Project Asset Prices and Macro Policy when Agents Learn
Researcher (PI) Albert Marcet Torrens
Host Institution (HI) FUNDACIÓ MARKETS, ORGANIZATIONS AND VOTES IN ECONOMICS
Call Details Advanced Grant (AdG), SH1, ERC-2012-ADG_20120411
Summary "A conventional assumption in dynamic models is that agents form their expectations in a very sophisticated manner. In particular, that they have Rational Expectations (RE). We develop some tools to relax this assumption while retaining fully optimal behaviour by agents. We study implications for asset pricing and macro policy.
We assume that agents have a consistent set of beliefs that is close, but not equal, to RE. Agents are ""Internally Rational"", that is, they behave rationally given their system of beliefs. Thus, it is conceptually a small deviation from RE. It provides microfoundations for models of adaptive learning, since the learning algorithm is determined by agents’ optimal behaviour. In previous work we have shown that this framework can match stock price and housing price fluctuations, and that policy implications are quite different.
In this project we intend to: i) develop further the foundations of internally rational (IR) learning, ii) apply this to explain observed asset price price behavior, such as stock prices, bond prices, inflation, commodity derivatives, and exchange rates, iii) extend the IR framework to the case when agents entertain various models, iv) optimal policy under IR learning and under private information when some hidden shocks are not revealed ex-post. Along the way we will address policy issues such as: effects of creating derivative markets, sovereign spread as a signal of sovereign default risk, tests of fiscal sustainability, fiscal policy when agents learn, monetary policy (more specifically, QE measures and interest rate policy), and the role of credibility in macro policy."
Summary
"A conventional assumption in dynamic models is that agents form their expectations in a very sophisticated manner. In particular, that they have Rational Expectations (RE). We develop some tools to relax this assumption while retaining fully optimal behaviour by agents. We study implications for asset pricing and macro policy.
We assume that agents have a consistent set of beliefs that is close, but not equal, to RE. Agents are ""Internally Rational"", that is, they behave rationally given their system of beliefs. Thus, it is conceptually a small deviation from RE. It provides microfoundations for models of adaptive learning, since the learning algorithm is determined by agents’ optimal behaviour. In previous work we have shown that this framework can match stock price and housing price fluctuations, and that policy implications are quite different.
In this project we intend to: i) develop further the foundations of internally rational (IR) learning, ii) apply this to explain observed asset price price behavior, such as stock prices, bond prices, inflation, commodity derivatives, and exchange rates, iii) extend the IR framework to the case when agents entertain various models, iv) optimal policy under IR learning and under private information when some hidden shocks are not revealed ex-post. Along the way we will address policy issues such as: effects of creating derivative markets, sovereign spread as a signal of sovereign default risk, tests of fiscal sustainability, fiscal policy when agents learn, monetary policy (more specifically, QE measures and interest rate policy), and the role of credibility in macro policy."
Max ERC Funding
1 970 260 €
Duration
Start date: 2013-06-01, End date: 2018-08-31
Project acronym ARCHOFCON
Project The Architecture of Consciousness
Researcher (PI) Timothy John Bayne
Host Institution (HI) THE UNIVERSITY OF MANCHESTER
Call Details Starting Grant (StG), SH4, ERC-2012-StG_20111124
Summary The nature of consciousness is one of the great unsolved mysteries of science. Although the global research effort dedicated to explaining how consciousness arises from neural and cognitive activity is now more than two decades old, as yet there is no widely accepted theory of consciousness. One reason for why no adequate theory of consciousness has yet been found is that there is a lack of clarity about what exactly a theory of consciousness needs to explain. What is needed is thus a model of the general features of consciousness — a model of the ‘architecture’ of consciousness — that will systematize the structural differences between conscious states, processes and creatures on the one hand and unconscious states, processes and creatures on the other. The aim of this project is to remove one of the central impediments to the progress of the science of consciousness by constructing such a model.
A great many of the data required for this task already exist, but these data concern different aspects of consciousness and are distributed across many disciplines. As a result, there have been few attempts to develop a truly comprehensive model of the architecture of consciousness. This project will overcome the limitations of previous work by drawing on research in philosophy, psychology, psychiatry, and cognitive neuroscience to develop a model of the architecture of consciousness that is structured around five of its core features: its subjectivity, its temporality, its unity, its selectivity, and its dimensionality (that is, the relationship between the levels of consciousness and the contents of consciousness). By providing a comprehensive characterization of what a theory of consciousness needs to explain, this project will provide a crucial piece of the puzzle of consciousness, enabling future generations of researchers to bridge the gap between raw data on the one hand and a full-blown theory of consciousness on the other
Summary
The nature of consciousness is one of the great unsolved mysteries of science. Although the global research effort dedicated to explaining how consciousness arises from neural and cognitive activity is now more than two decades old, as yet there is no widely accepted theory of consciousness. One reason for why no adequate theory of consciousness has yet been found is that there is a lack of clarity about what exactly a theory of consciousness needs to explain. What is needed is thus a model of the general features of consciousness — a model of the ‘architecture’ of consciousness — that will systematize the structural differences between conscious states, processes and creatures on the one hand and unconscious states, processes and creatures on the other. The aim of this project is to remove one of the central impediments to the progress of the science of consciousness by constructing such a model.
A great many of the data required for this task already exist, but these data concern different aspects of consciousness and are distributed across many disciplines. As a result, there have been few attempts to develop a truly comprehensive model of the architecture of consciousness. This project will overcome the limitations of previous work by drawing on research in philosophy, psychology, psychiatry, and cognitive neuroscience to develop a model of the architecture of consciousness that is structured around five of its core features: its subjectivity, its temporality, its unity, its selectivity, and its dimensionality (that is, the relationship between the levels of consciousness and the contents of consciousness). By providing a comprehensive characterization of what a theory of consciousness needs to explain, this project will provide a crucial piece of the puzzle of consciousness, enabling future generations of researchers to bridge the gap between raw data on the one hand and a full-blown theory of consciousness on the other
Max ERC Funding
1 477 483 €
Duration
Start date: 2013-03-01, End date: 2018-02-28
Project acronym ARSEM
Project LANGUAGE–PHILOLOGY–CULTURE: Arab Cultural Semantics in Transition
Researcher (PI) Kirill Dmitriev
Host Institution (HI) THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS
Call Details Starting Grant (StG), SH5, ERC-2012-StG_20111124
Summary This project aims to study:
• the semantic development of the vocabulary of the Arabic language,
• philological discourses on the semantic changes in the language in the classical Arabic philological tradition (8th-10th centuries A.D.), and
• the impact of Arabic philology in the wider historical and cultural context of the Judaeo-Arab neo-classical heritage (12th-13th centuries A.D.) and Christian-Arab intellectual history on the eve of modernity (19th century A.D.).
The project will explore the universal cultural significance and the pivotal role of language consciousness in the history of Arab culture. It will introduce a new dimension into the existing research on the Arabic language and Arabic philology, which until now have been studied without any comprehensive cultural and social contextualisation. The project will focus on the process of the transmission of Arabic poetry, which provides detailed evidence of the development of Arabic philological thought and its universal significance for the theological, philosophical, historical and linguistic discourses of Arab intellectual history. This project will document the transmission of early Arabic poetry and analyse its vocabulary in a systematic way for the first time. For this purpose it will create an Analytical Database of Arabic Poetry. This publicly accessible database will represent a ground-breaking contribution to European research on the Arabic language and the Arabic philological heritage, which so far lacks even such fundamental tools as an etymological dictionary of the Arabic language or a complete dictionary of Classical Arabic. The database will implement comprehensive analytical tools and will serve as a reference work for wider research on Arabic literature, history and culture. Thus, the project will create an integrative research platform for the history and semantics of the Arabic language—a subject indispensable for understanding the foundations of Arab culture past and present.
Summary
This project aims to study:
• the semantic development of the vocabulary of the Arabic language,
• philological discourses on the semantic changes in the language in the classical Arabic philological tradition (8th-10th centuries A.D.), and
• the impact of Arabic philology in the wider historical and cultural context of the Judaeo-Arab neo-classical heritage (12th-13th centuries A.D.) and Christian-Arab intellectual history on the eve of modernity (19th century A.D.).
The project will explore the universal cultural significance and the pivotal role of language consciousness in the history of Arab culture. It will introduce a new dimension into the existing research on the Arabic language and Arabic philology, which until now have been studied without any comprehensive cultural and social contextualisation. The project will focus on the process of the transmission of Arabic poetry, which provides detailed evidence of the development of Arabic philological thought and its universal significance for the theological, philosophical, historical and linguistic discourses of Arab intellectual history. This project will document the transmission of early Arabic poetry and analyse its vocabulary in a systematic way for the first time. For this purpose it will create an Analytical Database of Arabic Poetry. This publicly accessible database will represent a ground-breaking contribution to European research on the Arabic language and the Arabic philological heritage, which so far lacks even such fundamental tools as an etymological dictionary of the Arabic language or a complete dictionary of Classical Arabic. The database will implement comprehensive analytical tools and will serve as a reference work for wider research on Arabic literature, history and culture. Thus, the project will create an integrative research platform for the history and semantics of the Arabic language—a subject indispensable for understanding the foundations of Arab culture past and present.
Max ERC Funding
1 499 507 €
Duration
Start date: 2013-02-01, End date: 2019-01-31
