Project acronym COLLREGEN
Project Collagen scaffolds for bone regeneration: applied biomaterials, bioreactor and stem cell technology
Researcher (PI) Fergal Joseph O'brien
Host Institution (HI) ROYAL COLLEGE OF SURGEONS IN IRELAND
Call Details Starting Grant (StG), PE8, ERC-2009-StG
Summary Regenerative medicine aims to regenerate damaged tissues by developing functional cell, tissue, and organ substitutes to repair, replace or enhance biological function in damaged tissues. The focus of this research programme is to develop bone graft substitute biomaterials and laboratory-engineered bone tissue for implantation in damaged sites. At a simplistic level, biological tissues consist of cells, signalling mechanisms and extracellular matrix. Regenerative medicine/tissue engineering technologies are based on this biological triad and involve the successful interaction between three components: the scaffold that holds the cells together to create the tissues physical form, the cells that create the tissue, and the biological signalling mechanisms (such as growth factors or bioreactors) that direct the cells to express the desired tissue phenotype. The research proposed in this project includes specific projects in all three areas. The programme will be centred on the collagen-based biomaterials developed in the applicant s laboratory and will incorporate cutting edge stem cell technologies, growth factor delivery, gene therapy and bioreactor technology which will translate to in vivo tissue repair. This translational research programme will be divided into four specific themes: (i) development of novel osteoinductive and angiogenic smart scaffolds for bone tissue regeneration, (ii) scaffold and stem cell therapies for bone tissue regeneration, (iii) bone tissue engineering using a flow perfusion bioreactor and (iv) in vivo bone repair using engineered bone and smart scaffolds.
Summary
Regenerative medicine aims to regenerate damaged tissues by developing functional cell, tissue, and organ substitutes to repair, replace or enhance biological function in damaged tissues. The focus of this research programme is to develop bone graft substitute biomaterials and laboratory-engineered bone tissue for implantation in damaged sites. At a simplistic level, biological tissues consist of cells, signalling mechanisms and extracellular matrix. Regenerative medicine/tissue engineering technologies are based on this biological triad and involve the successful interaction between three components: the scaffold that holds the cells together to create the tissues physical form, the cells that create the tissue, and the biological signalling mechanisms (such as growth factors or bioreactors) that direct the cells to express the desired tissue phenotype. The research proposed in this project includes specific projects in all three areas. The programme will be centred on the collagen-based biomaterials developed in the applicant s laboratory and will incorporate cutting edge stem cell technologies, growth factor delivery, gene therapy and bioreactor technology which will translate to in vivo tissue repair. This translational research programme will be divided into four specific themes: (i) development of novel osteoinductive and angiogenic smart scaffolds for bone tissue regeneration, (ii) scaffold and stem cell therapies for bone tissue regeneration, (iii) bone tissue engineering using a flow perfusion bioreactor and (iv) in vivo bone repair using engineered bone and smart scaffolds.
Max ERC Funding
1 999 530 €
Duration
Start date: 2009-11-01, End date: 2015-09-30
Project acronym LIMOD
Project The Limits of Demobilization, 1917-1923: Paramilitary Violence in Europe and the Wider World
Researcher (PI) Robert Benjamin Gerwarth
Host Institution (HI) UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Call Details Starting Grant (StG), SH6, ERC-2009-StG
Summary The purpose of the proposed project is to think afresh about the violent aftermath of the Great War and its legacies. This will be achieved by forging a team of researchers who focus on the violent conflicts that erupted in many of the former combatant states after 1917/18 from a comparative or transnational global perspective and the ways in which these conflicts were avoided in other areas. The project will differ from previous attempts to analyse the violent transition from war to peace in this period in several ways: The first is its comparative and transational complexion. Despite recent attempts to write transnational histories of the Great War, the global history of its immediate aftermath is yet to be written. War and the politics of conflicts (and its aftermaths) are still largely studied according to divisions of national identity or ethnic difference. And yet clearly the First World War was a phenomenon that crossed frontiers and left legacies that posessed common themes. Indeed one of its consequences, especially in East-Central Europe but also in the shatter-zones of the Ottoman Empire and colonial contexts, was the destruction of frontiers, creating spaces without order or unquestioned government authority. The project will thus approach its subject matter by zones of victory, of defeat, and of mutilated or ambivalent victories rather than nation-states as a novel way of overcoming nation-centric frameworks of analysis. In terms of chronological scope, the investigation moves away from the traditional emphasis on the years 1914-18 as the crucible years of twentieth-century history. Furthermore, the project is at once European and global, investigating the emergence of violent conflicts in both the shatter-zones of European land empires and colonial conflicts.
Summary
The purpose of the proposed project is to think afresh about the violent aftermath of the Great War and its legacies. This will be achieved by forging a team of researchers who focus on the violent conflicts that erupted in many of the former combatant states after 1917/18 from a comparative or transnational global perspective and the ways in which these conflicts were avoided in other areas. The project will differ from previous attempts to analyse the violent transition from war to peace in this period in several ways: The first is its comparative and transational complexion. Despite recent attempts to write transnational histories of the Great War, the global history of its immediate aftermath is yet to be written. War and the politics of conflicts (and its aftermaths) are still largely studied according to divisions of national identity or ethnic difference. And yet clearly the First World War was a phenomenon that crossed frontiers and left legacies that posessed common themes. Indeed one of its consequences, especially in East-Central Europe but also in the shatter-zones of the Ottoman Empire and colonial contexts, was the destruction of frontiers, creating spaces without order or unquestioned government authority. The project will thus approach its subject matter by zones of victory, of defeat, and of mutilated or ambivalent victories rather than nation-states as a novel way of overcoming nation-centric frameworks of analysis. In terms of chronological scope, the investigation moves away from the traditional emphasis on the years 1914-18 as the crucible years of twentieth-century history. Furthermore, the project is at once European and global, investigating the emergence of violent conflicts in both the shatter-zones of European land empires and colonial conflicts.
Max ERC Funding
1 199 386 €
Duration
Start date: 2009-09-01, End date: 2014-02-28
Project acronym RLPHARMFMRI
Project Beyond dopamine: Characterizing the computational functions of midbrain modulatory neurotransmitter systems in human reinforcement learning using model-based pharmacological fMRI
Researcher (PI) John O'doherty
Host Institution (HI) THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Call Details Starting Grant (StG), LS5, ERC-2009-StG
Summary Understanding how humans and other animals are able to learn from experience and use this information to select future behavioural strategies to obtain the reinforcers necessary for survival, is a fundamental research question in biology. Considerable progress has been made in recent years on the neural computational underpinnings of this process following the observation that the phasic activity of dopamine neurons in the midbrain resembles a prediction error from a formal computational theory known as reinforcement learning (RL). While much is known about the functions of dopamine in RL, much less is known about the computational functions of other modulatory neurotransmitter systems in the midbrain such as the cholinergic, norcpinephrine, and serotonergic systems. The goal of this research proposal to the ERC, is to begin a systematic study of the computational functions of these other neurotransmitter systems (beyond dopamine) in RL. To do this we will combine functional magnetic resonance imaging in human subjects while they perform simple decision making tasks and undergo pharmacological manipulations to modulate systemic levels of these different neurotransmitter systems. We will combine computational model-based analyses with fMRI and behavioural data in order to explore the effects that these pharmacological modulations exert on different parameters and modules within RL. Specifically, we will test the contributions that the cholinergic system makes in setting the learning rate during RL and in mediating computations of expected uncertainty in the distribution of rewards available, we will test for the role of norepinephrine in balancing the rate of exploration and exploitation during decision making, as well as in encoding the level of unexpected uncertainty, and we will explore the possible role of serotonin in setting the rate of temporal discounting for reward, or in encoding prediction errors during aversive as opposed to reward-learning.
Summary
Understanding how humans and other animals are able to learn from experience and use this information to select future behavioural strategies to obtain the reinforcers necessary for survival, is a fundamental research question in biology. Considerable progress has been made in recent years on the neural computational underpinnings of this process following the observation that the phasic activity of dopamine neurons in the midbrain resembles a prediction error from a formal computational theory known as reinforcement learning (RL). While much is known about the functions of dopamine in RL, much less is known about the computational functions of other modulatory neurotransmitter systems in the midbrain such as the cholinergic, norcpinephrine, and serotonergic systems. The goal of this research proposal to the ERC, is to begin a systematic study of the computational functions of these other neurotransmitter systems (beyond dopamine) in RL. To do this we will combine functional magnetic resonance imaging in human subjects while they perform simple decision making tasks and undergo pharmacological manipulations to modulate systemic levels of these different neurotransmitter systems. We will combine computational model-based analyses with fMRI and behavioural data in order to explore the effects that these pharmacological modulations exert on different parameters and modules within RL. Specifically, we will test the contributions that the cholinergic system makes in setting the learning rate during RL and in mediating computations of expected uncertainty in the distribution of rewards available, we will test for the role of norepinephrine in balancing the rate of exploration and exploitation during decision making, as well as in encoding the level of unexpected uncertainty, and we will explore the possible role of serotonin in setting the rate of temporal discounting for reward, or in encoding prediction errors during aversive as opposed to reward-learning.
Max ERC Funding
1 841 404 €
Duration
Start date: 2010-01-01, End date: 2010-09-30
