Project acronym AARTFAAC
Project Amsterdam-ASTRON Radio Transient Facility And Analysis Centre: Probing the Extremes of Astrophysics
Researcher (PI) Ralph Antoine Marie Joseph Wijers
Host Institution (HI) UNIVERSITEIT VAN AMSTERDAM
Call Details Advanced Grant (AdG), PE9, ERC-2009-AdG
Summary Some of the most extreme tests of physical law come from its manifestations in the behaviour of black holes and neutron stars, and as such these objects should be used as fundamental physics labs. Due to advances in both theoretical work and observational techniques, I have a major opportunity now to significantly push this agenda forward and get better answers to questions like: How are black holes born? How can energy be extracted from black holes? What is the origin of magnetic fields and cosmic rays in jets and shocks? Is their primary energy stream hadronic or magnetic? I propose to do this by exploiting the advent of wide-field radio astronomy: extreme objects are very rare and usually transient, so not only must one survey large areas of sky, but also must one do this often. I propose to form and shape a group that will use the LOFAR wide-field radio telescope to hunt for these extreme transients and systematically collect enough well-documented examples of the behaviour of each type of transient. Furthermore, I propose to expand LOFAR with a true 24/7 all-sky monitor to catch and study even the rarest of events. Next, I will use my experience in gamma-ray burst followup to conduct a vigorous multi-wavelength programme of study of these objects, to constrain their physics from as many angles as possible. This will eventually include results from multi-messenger astrophysics, in which we use neutrinos, gravity waves, and other non-electromagnetic messengers as extra diagnostics of the physics of these sources. Finally, I will build on my experience in modelling accretion phenomena and relativistic explosions to develop a theoretical framework for these phenomena and constrain the resulting models with the rich data sets we obtain.
Summary
Some of the most extreme tests of physical law come from its manifestations in the behaviour of black holes and neutron stars, and as such these objects should be used as fundamental physics labs. Due to advances in both theoretical work and observational techniques, I have a major opportunity now to significantly push this agenda forward and get better answers to questions like: How are black holes born? How can energy be extracted from black holes? What is the origin of magnetic fields and cosmic rays in jets and shocks? Is their primary energy stream hadronic or magnetic? I propose to do this by exploiting the advent of wide-field radio astronomy: extreme objects are very rare and usually transient, so not only must one survey large areas of sky, but also must one do this often. I propose to form and shape a group that will use the LOFAR wide-field radio telescope to hunt for these extreme transients and systematically collect enough well-documented examples of the behaviour of each type of transient. Furthermore, I propose to expand LOFAR with a true 24/7 all-sky monitor to catch and study even the rarest of events. Next, I will use my experience in gamma-ray burst followup to conduct a vigorous multi-wavelength programme of study of these objects, to constrain their physics from as many angles as possible. This will eventually include results from multi-messenger astrophysics, in which we use neutrinos, gravity waves, and other non-electromagnetic messengers as extra diagnostics of the physics of these sources. Finally, I will build on my experience in modelling accretion phenomena and relativistic explosions to develop a theoretical framework for these phenomena and constrain the resulting models with the rich data sets we obtain.
Max ERC Funding
3 499 128 €
Duration
Start date: 2010-10-01, End date: 2016-09-30
Project acronym BABYLON
Project By the Rivers of Babylon: New Perspectives on Second Temple Judaism from Cuneiform Texts
Researcher (PI) Caroline Waerzeggers
Host Institution (HI) UNIVERSITEIT LEIDEN
Call Details Starting Grant (StG), SH6, ERC-2009-StG
Summary This project has the potential to radically change current understanding of cultic and social transformation in the post-exilic temple community of Jerusalem (c. 6th-4th centuries BCE), an important formative phase of ancient Judaism. “BABYLON” draws on recent, ground-breaking advances in the study of cuneiform texts to illuminate the Babylonian environment of the Judean exile, the socio-historical context which gave rise to the transformative era in Second Temple Judaism. In particular, these new data show that the parallels between Babylonian and post-exilic forms of cultic and social organization were substantially more far-reaching than presently recognized in Biblical scholarship. “BABYLON” will study the extent of these similarities and explore the question how Babylonian models could have influenced the restoration effort in Jerusalem.
This goal will be achieved through four sub-projects. P1 will study the social dynamics and intellectual universe of the Babylonian priesthood. P2 will finalize the publication of cuneiform archives of Babylonian priests living in the time of the exile. P3 will identify the exact areas of change in the post-exilic temple community of Jerusalem. P4, the synthesis, will draw from each of these sub-projects to present a comparative study of the Second Temple and contemporary Babylonian models of cultic and social organization, and to propose a strategy of research into the possible routes of transmission between Babylonia and Jerusalem.
The research will be carried out by three team members: the PI (P1 and P4), a PhD in Assyriology (P2) and a post-doctoral researcher in Biblical Studies specialized in the Second Temple period (P3 and P4). The participation of the wider academic community will be invited at two moments in the course of the project, in the form of a workshop and an international conference.
“BABYLON” will adopt an interdisciplinary approach by bringing together Assyriologists and Biblical scholars for a much-needed dialogue, thereby exploding the artificial boundaries that currently exist in the academic landscape between these two fields.
Summary
This project has the potential to radically change current understanding of cultic and social transformation in the post-exilic temple community of Jerusalem (c. 6th-4th centuries BCE), an important formative phase of ancient Judaism. “BABYLON” draws on recent, ground-breaking advances in the study of cuneiform texts to illuminate the Babylonian environment of the Judean exile, the socio-historical context which gave rise to the transformative era in Second Temple Judaism. In particular, these new data show that the parallels between Babylonian and post-exilic forms of cultic and social organization were substantially more far-reaching than presently recognized in Biblical scholarship. “BABYLON” will study the extent of these similarities and explore the question how Babylonian models could have influenced the restoration effort in Jerusalem.
This goal will be achieved through four sub-projects. P1 will study the social dynamics and intellectual universe of the Babylonian priesthood. P2 will finalize the publication of cuneiform archives of Babylonian priests living in the time of the exile. P3 will identify the exact areas of change in the post-exilic temple community of Jerusalem. P4, the synthesis, will draw from each of these sub-projects to present a comparative study of the Second Temple and contemporary Babylonian models of cultic and social organization, and to propose a strategy of research into the possible routes of transmission between Babylonia and Jerusalem.
The research will be carried out by three team members: the PI (P1 and P4), a PhD in Assyriology (P2) and a post-doctoral researcher in Biblical Studies specialized in the Second Temple period (P3 and P4). The participation of the wider academic community will be invited at two moments in the course of the project, in the form of a workshop and an international conference.
“BABYLON” will adopt an interdisciplinary approach by bringing together Assyriologists and Biblical scholars for a much-needed dialogue, thereby exploding the artificial boundaries that currently exist in the academic landscape between these two fields.
Max ERC Funding
1 200 000 €
Duration
Start date: 2009-09-01, End date: 2015-08-31
Project acronym BEAUTY
Project Towards a comparative sociology of beauty The transnational modelling industry and the social shaping of beauty standards in six European countries
Researcher (PI) Giselinde Maniouschka Marije Kuipers
Host Institution (HI) UNIVERSITEIT VAN AMSTERDAM
Call Details Starting Grant (StG), SH2, ERC-2009-StG
Summary This project studies how beauty standards - perceptions of physical beauty in women and men - are socially shaped. It will focus on the transnational modelling industry, an institution centrally concerned with the production and dissemination of beauty standards. The project aims to develop a comparative sociology of beauty. By comparing beauty standards both within and across nations, it will identify central mechanisms and institutions through which such standards are developed and disseminated. In 4 subprojects this study investigates 1. How standards of female and male beauty are perceived, shaped, and disseminated by professionals in the transnational modelling field; 2. How female and male models perceive, represent and embody beauty standards in their work; 3. How female and male beauty has been portrayed by models in mainstream and high fashion magazines from 1980 till 2010; 4. How people of different backgrounds perceive female and male beauty, and how their beauty standards are related to the images disseminated in modelling. Each project will be done in France, Italy, the Netherlands, Poland, Turkey and the UK. This project is innovative in several ways. It is the first comprehensive study of the social shaping of beauty standards. The 4 subprojects will result in an extensive account of production, products, and reception of a contested cultural industry. Moreover, this project draws together in novel ways theories about media, cultural production and taste formation; gender and the body; and globalization. The project will make a major contribution to the study of globalization: it studies a transnational cultural industry, and its comparative and longitudinal design allows us to gauge the impact of globalization in different contexts. Finally, the project is innovative in its comparative, multi-method research design, in which the subprojects will follow the entire process of production and consumption in a transnational field.
Summary
This project studies how beauty standards - perceptions of physical beauty in women and men - are socially shaped. It will focus on the transnational modelling industry, an institution centrally concerned with the production and dissemination of beauty standards. The project aims to develop a comparative sociology of beauty. By comparing beauty standards both within and across nations, it will identify central mechanisms and institutions through which such standards are developed and disseminated. In 4 subprojects this study investigates 1. How standards of female and male beauty are perceived, shaped, and disseminated by professionals in the transnational modelling field; 2. How female and male models perceive, represent and embody beauty standards in their work; 3. How female and male beauty has been portrayed by models in mainstream and high fashion magazines from 1980 till 2010; 4. How people of different backgrounds perceive female and male beauty, and how their beauty standards are related to the images disseminated in modelling. Each project will be done in France, Italy, the Netherlands, Poland, Turkey and the UK. This project is innovative in several ways. It is the first comprehensive study of the social shaping of beauty standards. The 4 subprojects will result in an extensive account of production, products, and reception of a contested cultural industry. Moreover, this project draws together in novel ways theories about media, cultural production and taste formation; gender and the body; and globalization. The project will make a major contribution to the study of globalization: it studies a transnational cultural industry, and its comparative and longitudinal design allows us to gauge the impact of globalization in different contexts. Finally, the project is innovative in its comparative, multi-method research design, in which the subprojects will follow the entire process of production and consumption in a transnational field.
Max ERC Funding
1 202 611 €
Duration
Start date: 2010-05-01, End date: 2015-08-31
Project acronym BOYS WILL BE BOYS?
Project Boys will be boys? Gender differences in the socialization of disruptive behaviour in early childhood
Researcher (PI) Judit Mesman
Host Institution (HI) UNIVERSITEIT LEIDEN
Call Details Starting Grant (StG), SH4, ERC-2009-StG
Summary The aim of the proposed project is to shed light on early childhood gender-differentiated socialization and gender-specific susceptibility to parenting within families in relation to disruptive behaviour in boys and girls in the first four years of life. The popular saying boys will be boys refers to the observation that boys show more disruptive behaviours (e.g., noncompliance or aggression) than girls, a pattern that has been confirmed frequently in scientific research. There is also evidence that parents treat boys differently from girls in ways that are likely to foster boys disruptive behaviour, and that boys are more susceptible to problematic family functioning than girls. The crucial question is whether gender differences in socialization, susceptibility to socialization, and children s behavioural outcomes are also salient when the same parents are doing the parenting of both a boy and a girl. Within-family comparisons are necessary to account for structural differences between families. To this end, families with two children born 22-26 months apart will be recruited from the general population. To account for birth order and gender-combination effects, the sample includes four groups of 150 families each, with the following sibling combinations: girl-boy, boy-girl, girl-girl, and boy-boy. The study has a four-wave longitudinal design, based on the youngest sibling with assessments at ages 12, 24, 36, and 48 months, because gender differences in disruptive behaviour develop during the toddler years. Each assessment consists of two home visits: one with mother and one with father, including observations of both children and of the children separately. Parenting behaviours will be studied in reaction to specific child behaviours, including aggression, noncompliance, and prosocial behaviours.
Summary
The aim of the proposed project is to shed light on early childhood gender-differentiated socialization and gender-specific susceptibility to parenting within families in relation to disruptive behaviour in boys and girls in the first four years of life. The popular saying boys will be boys refers to the observation that boys show more disruptive behaviours (e.g., noncompliance or aggression) than girls, a pattern that has been confirmed frequently in scientific research. There is also evidence that parents treat boys differently from girls in ways that are likely to foster boys disruptive behaviour, and that boys are more susceptible to problematic family functioning than girls. The crucial question is whether gender differences in socialization, susceptibility to socialization, and children s behavioural outcomes are also salient when the same parents are doing the parenting of both a boy and a girl. Within-family comparisons are necessary to account for structural differences between families. To this end, families with two children born 22-26 months apart will be recruited from the general population. To account for birth order and gender-combination effects, the sample includes four groups of 150 families each, with the following sibling combinations: girl-boy, boy-girl, girl-girl, and boy-boy. The study has a four-wave longitudinal design, based on the youngest sibling with assessments at ages 12, 24, 36, and 48 months, because gender differences in disruptive behaviour develop during the toddler years. Each assessment consists of two home visits: one with mother and one with father, including observations of both children and of the children separately. Parenting behaviours will be studied in reaction to specific child behaviours, including aggression, noncompliance, and prosocial behaviours.
Max ERC Funding
1 611 970 €
Duration
Start date: 2010-02-01, End date: 2015-03-31
Project acronym DIRECTDELIVERY
Project Controlled fusion of liposomes and cells: a new pathway for direct drug delivery
Researcher (PI) Alexander Kros
Host Institution (HI) UNIVERSITEIT LEIDEN
Call Details Starting Grant (StG), PE5, ERC-2009-StG
Summary Inspired by the natural membrane fusion machinery, the aim of this research line is to design a synthetic analogue in order to: 1) Understand the process of the peptide-controlled fusion of two membranes at the atomic, molecular and mesoscopic level. 2) Developing a new generic method for the controlled delivery of any (bio)molecule directly into the cytoplasm of a cell thereby omitting endocytotic pathways. This new paradigm opens many new applications in the fields of functional proteomics, genomics and siRNA-technology. Studying, imitating and dissecting processes from Nature and applying the underlying principles has been highly successful approach for many years and opened up new lines of research and applications which were previously unimagineable. Examples are the aptamer and antibody technology. I will use this learning-from-Nature approach to design synthetic analogues of the membrane fusion machinery to create new functions and/or applications which are currently non-existent. Membrane fusion is a key process in all living cells as it facilitates the transport of molecules between and within cells. A primary mechanism by which molecules are conveyed to the appropriate location is to encapsulate them in liposomes that deliver the cargo by fusing with the lipid membrane of the target cell or compartment. I will use synthetic analogues of the membrane fusion machinery to induce the controlled fusion between 1) specific liposomes and 2) liposome-cell. This approach opens up a new paradigm for the direct introduction of (bio)molecule into the cytoplasm of living cells omitting the endocytotic pathways for which the applications are only limited by one s imagination.
Summary
Inspired by the natural membrane fusion machinery, the aim of this research line is to design a synthetic analogue in order to: 1) Understand the process of the peptide-controlled fusion of two membranes at the atomic, molecular and mesoscopic level. 2) Developing a new generic method for the controlled delivery of any (bio)molecule directly into the cytoplasm of a cell thereby omitting endocytotic pathways. This new paradigm opens many new applications in the fields of functional proteomics, genomics and siRNA-technology. Studying, imitating and dissecting processes from Nature and applying the underlying principles has been highly successful approach for many years and opened up new lines of research and applications which were previously unimagineable. Examples are the aptamer and antibody technology. I will use this learning-from-Nature approach to design synthetic analogues of the membrane fusion machinery to create new functions and/or applications which are currently non-existent. Membrane fusion is a key process in all living cells as it facilitates the transport of molecules between and within cells. A primary mechanism by which molecules are conveyed to the appropriate location is to encapsulate them in liposomes that deliver the cargo by fusing with the lipid membrane of the target cell or compartment. I will use synthetic analogues of the membrane fusion machinery to induce the controlled fusion between 1) specific liposomes and 2) liposome-cell. This approach opens up a new paradigm for the direct introduction of (bio)molecule into the cytoplasm of living cells omitting the endocytotic pathways for which the applications are only limited by one s imagination.
Max ERC Funding
1 392 262 €
Duration
Start date: 2009-10-01, End date: 2014-09-30
Project acronym EATINGBODIES
Project The eating body in Western practice and theory
Researcher (PI) Anne-Marie Mol
Host Institution (HI) UNIVERSITEIT VAN AMSTERDAM
Call Details Advanced Grant (AdG), SH2, ERC-2009-AdG
Summary Human bodies eat. But what does this entail? The proposed project will explore how the eating body is shaped in different Western practices. These will include nutritional research and health care clinics, sites that have a far-reaching impact on how we eat. Four related sub-projects will trace the most relevant contrasts: (1) the eating body's health: limiting calorie intake versus maximising satisfaction; (2) the eating body's sensitivity: on tasting in various practices; (3) the eating body and other eaters: on different ways of relating individual and collective; (4) the eating body and its environment: on absorbing food, excreting waste and different bodily boundaries. These four sub-projects will together inform an anthropology of the eating body in Western practices. A fifth sub-project will attend to the eater in theory . Eating may be ubiquitous in practice, but it is strikingly absent from theorising in the Western philosophical tradition. This has profound implications for social science repertoires, which tend to include an actor modelled on the neuromuscular body. This actor sees, hears, moves and manipulates, but does not eat. Drawing on what we learn about the eating body in the empirical parts of the study, the fifth sub-project will model the actor on the eater. Eaters do not observe from a distance, but are mixed up with their surroundings. They do not judge impartially, but appreciate their food as they destroy it. Their metabolic activity, distributed over every cell, does not depend on central control. The theoretical possibilities that follow, will be experimentally explored. Thus the project aims to substantially enrich the Western tradition by feeding it with lessons drawn from its own marginalised experiences.
Summary
Human bodies eat. But what does this entail? The proposed project will explore how the eating body is shaped in different Western practices. These will include nutritional research and health care clinics, sites that have a far-reaching impact on how we eat. Four related sub-projects will trace the most relevant contrasts: (1) the eating body's health: limiting calorie intake versus maximising satisfaction; (2) the eating body's sensitivity: on tasting in various practices; (3) the eating body and other eaters: on different ways of relating individual and collective; (4) the eating body and its environment: on absorbing food, excreting waste and different bodily boundaries. These four sub-projects will together inform an anthropology of the eating body in Western practices. A fifth sub-project will attend to the eater in theory . Eating may be ubiquitous in practice, but it is strikingly absent from theorising in the Western philosophical tradition. This has profound implications for social science repertoires, which tend to include an actor modelled on the neuromuscular body. This actor sees, hears, moves and manipulates, but does not eat. Drawing on what we learn about the eating body in the empirical parts of the study, the fifth sub-project will model the actor on the eater. Eaters do not observe from a distance, but are mixed up with their surroundings. They do not judge impartially, but appreciate their food as they destroy it. Their metabolic activity, distributed over every cell, does not depend on central control. The theoretical possibilities that follow, will be experimentally explored. Thus the project aims to substantially enrich the Western tradition by feeding it with lessons drawn from its own marginalised experiences.
Max ERC Funding
1 848 701 €
Duration
Start date: 2010-03-01, End date: 2015-02-28
Project acronym ENTCHILD
Project The Entertainization of Childhood: An Etiology of Risks and Opportunities
Researcher (PI) Patricia Maria Valkenburg
Host Institution (HI) UNIVERSITEIT VAN AMSTERDAM
Call Details Advanced Grant (AdG), SH2, ERC-2009-AdG
Summary Never before has media entertainment been so abundantly accessible to children. In this project, I propose an entirely new theoretical model to understand entertainment processing and effects. The model enables us to simultaneously investigate: (a) how and why certain types of media entertainment may influence certain children, (b) which children are particularly susceptible to positive, which to negative, and which to both positive and negative entertainment effects, and (c) how children s social environment can maximize positive and minimize negative entertainment effects on children. The project involves a longitudinal panel study among 900 Dutch families. To measure the variables in the model, we will use some well-established survey instruments and neuropsychological tests. We will also employ two less conventional methods (coded media-use diaries and experience sampling methods) that may enhance serendipity in the development of our theory-advancing insights. We will use state-of-the art data-analytic techniques (e.g., multi-level and latent-growth curve modelling) to analyse the data. Although adventurous, this transdisciplinary project, the first in its kind, has great theoretical significance. If the assumptions of my model are supported, it may lead to a fundamental re-evaluation of earlier media-effects theories and research on children. The project will also have tremendous social relevance, not only for parents, but also for programme makers, educators, and the society as a whole. After all, only if we truly understand why, how, and which children are influenced by certain types of media entertainment, are we able to adequately target prevention and intervention strategies at these children.
Summary
Never before has media entertainment been so abundantly accessible to children. In this project, I propose an entirely new theoretical model to understand entertainment processing and effects. The model enables us to simultaneously investigate: (a) how and why certain types of media entertainment may influence certain children, (b) which children are particularly susceptible to positive, which to negative, and which to both positive and negative entertainment effects, and (c) how children s social environment can maximize positive and minimize negative entertainment effects on children. The project involves a longitudinal panel study among 900 Dutch families. To measure the variables in the model, we will use some well-established survey instruments and neuropsychological tests. We will also employ two less conventional methods (coded media-use diaries and experience sampling methods) that may enhance serendipity in the development of our theory-advancing insights. We will use state-of-the art data-analytic techniques (e.g., multi-level and latent-growth curve modelling) to analyse the data. Although adventurous, this transdisciplinary project, the first in its kind, has great theoretical significance. If the assumptions of my model are supported, it may lead to a fundamental re-evaluation of earlier media-effects theories and research on children. The project will also have tremendous social relevance, not only for parents, but also for programme makers, educators, and the society as a whole. After all, only if we truly understand why, how, and which children are influenced by certain types of media entertainment, are we able to adequately target prevention and intervention strategies at these children.
Max ERC Funding
2 500 000 €
Duration
Start date: 2010-12-01, End date: 2016-08-31
Project acronym EXACTA
Project Exploring the aggressiveness of prostate cancer to enable an individualised treatment approach
Researcher (PI) Thomas Wilhelmus Jacobus Scheenen
Host Institution (HI) STICHTING KATHOLIEKE UNIVERSITEIT
Call Details Starting Grant (StG), LS7, ERC-2009-StG
Summary Prostate cancer is the most frequently diagnosed malignancy in the western male population and the associated socio-economic impact on healthcare is more than worrying. There is one key feature of confined (stage T2) prostate cancer that needs to be addressed with immediate urgency: its true aggressiveness. Not all cancers are life threatening and early diagnosis, although needed to improve outcome, will lead to overtreatment of patients with indolent prostate cancer resulting in unnecessary treatment-related morbidity. Therefore, methods to identify clinically significant forms of prostate cancer have to be developed. To pursue this, the initial assessment of the extent of the disease process (clinical staging) needs to be adequate. Obtaining pre-treatment representative tumor tissue (biopsies) is a major clinical challenge, as the disease is often multi-focal and heterogeneous. Accurate functional in vivo imaging modalities could guide these biopsies. Modern genomics technologies have identified numerous cancer cell-associated genetic markers being expressed in prostate cancer tissue or body fluids. Closing the gap between genomics and a non-invasive metabolic assessment of the in vivo prostate, we propose to identify new in vivo targets/biomarkers indicating confined prostate cancer aggressiveness with the underlying central hypothesis: early functional metabolic differences in different tumor foci determine whether it will grow into life-threatening prostate cancer or not. To track these early metabolic differences, the very latest magnetic resonance methodologies, including 13C MR of hyperpolarized metabolites and 1H- and 31P-MRSI of the in vivo human prostate at a field strength of 7 Tesla, will be further developed and implemented. In the well-established translational research environment at the host institution, potential new biomarkers translate into molecular diagnostics or imaging tools for an accurate individual assessment of cancer aggressiveness.
Summary
Prostate cancer is the most frequently diagnosed malignancy in the western male population and the associated socio-economic impact on healthcare is more than worrying. There is one key feature of confined (stage T2) prostate cancer that needs to be addressed with immediate urgency: its true aggressiveness. Not all cancers are life threatening and early diagnosis, although needed to improve outcome, will lead to overtreatment of patients with indolent prostate cancer resulting in unnecessary treatment-related morbidity. Therefore, methods to identify clinically significant forms of prostate cancer have to be developed. To pursue this, the initial assessment of the extent of the disease process (clinical staging) needs to be adequate. Obtaining pre-treatment representative tumor tissue (biopsies) is a major clinical challenge, as the disease is often multi-focal and heterogeneous. Accurate functional in vivo imaging modalities could guide these biopsies. Modern genomics technologies have identified numerous cancer cell-associated genetic markers being expressed in prostate cancer tissue or body fluids. Closing the gap between genomics and a non-invasive metabolic assessment of the in vivo prostate, we propose to identify new in vivo targets/biomarkers indicating confined prostate cancer aggressiveness with the underlying central hypothesis: early functional metabolic differences in different tumor foci determine whether it will grow into life-threatening prostate cancer or not. To track these early metabolic differences, the very latest magnetic resonance methodologies, including 13C MR of hyperpolarized metabolites and 1H- and 31P-MRSI of the in vivo human prostate at a field strength of 7 Tesla, will be further developed and implemented. In the well-established translational research environment at the host institution, potential new biomarkers translate into molecular diagnostics or imaging tools for an accurate individual assessment of cancer aggressiveness.
Max ERC Funding
1 800 209 €
Duration
Start date: 2010-03-01, End date: 2015-02-28
Project acronym FLUPLAN
Project Novel strategies to combat future influenza pandemics
Researcher (PI) Albertus Dominicus Marcellinus Erasmus Osterhaus
Host Institution (HI) ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Call Details Advanced Grant (AdG), LS7, ERC-2009-AdG
Summary The Mexican influenza A virus (H1N1) reminds us that the threat of an influenza pandemic is real. The 1918 Spanish flu virus, also started as a low pathogenic virus that mutated into a highly pathogenic virus within months, causing more than 50 million deaths. The Mexican influenza A virus (H1N1) may follow the same path. FLUPLAN will expand our knowledge of the packaging signals that govern reassortment events between influenza A viruses in general and between the Mexican influenza A virus (H1N1) and circulating human, porcine and highly pathogenic avian influenza A viruses in particular. FLUPLAN will thus lead to fundamental insights in the mechanisms that govern reassortment phenomena, providing a risk assessment concerning the pandemic potential of circulating avian and mammalian influenza A viruses. This will provide us with a panel of possible reassortant viruses of potentially pandemic nature. The MVA vaccine vector system that efficiently induced broad protective immunity against HPAI-H5N1 viruses in macaques, will be used for the preparation of a repository of MVA-H based pandemic vaccine seed viruses.The selection will be based on the reassortant viruses mentioned above, and on a repository of avian influenza viruses of the 16HA subtypes including the Mexican influenza A virus (H1N1) of avian/swine origin. The added value of including a relevant MVA-NP in the immunization schedule to obtain broader and longer protection will be determined in a macaque infection model. Collectively these studies will provide us with a highly versatile system that anticipates on future pandemic events by having seed viruses for vaccine development ready to go on the shelf, for the rapid production of broadly protective pandemic vaccines, which will save time and thus lives.
Summary
The Mexican influenza A virus (H1N1) reminds us that the threat of an influenza pandemic is real. The 1918 Spanish flu virus, also started as a low pathogenic virus that mutated into a highly pathogenic virus within months, causing more than 50 million deaths. The Mexican influenza A virus (H1N1) may follow the same path. FLUPLAN will expand our knowledge of the packaging signals that govern reassortment events between influenza A viruses in general and between the Mexican influenza A virus (H1N1) and circulating human, porcine and highly pathogenic avian influenza A viruses in particular. FLUPLAN will thus lead to fundamental insights in the mechanisms that govern reassortment phenomena, providing a risk assessment concerning the pandemic potential of circulating avian and mammalian influenza A viruses. This will provide us with a panel of possible reassortant viruses of potentially pandemic nature. The MVA vaccine vector system that efficiently induced broad protective immunity against HPAI-H5N1 viruses in macaques, will be used for the preparation of a repository of MVA-H based pandemic vaccine seed viruses.The selection will be based on the reassortant viruses mentioned above, and on a repository of avian influenza viruses of the 16HA subtypes including the Mexican influenza A virus (H1N1) of avian/swine origin. The added value of including a relevant MVA-NP in the immunization schedule to obtain broader and longer protection will be determined in a macaque infection model. Collectively these studies will provide us with a highly versatile system that anticipates on future pandemic events by having seed viruses for vaccine development ready to go on the shelf, for the rapid production of broadly protective pandemic vaccines, which will save time and thus lives.
Max ERC Funding
2 187 758 €
Duration
Start date: 2010-06-01, End date: 2015-05-31
Project acronym FUNCTIONAL GENOMICS
Project DISSECTING GENETIC DEPENDENCIES IN CANCER
Researcher (PI) René Bernards
Host Institution (HI) STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
Call Details Advanced Grant (AdG), LS2, ERC-2009-AdG
Summary While significant progress has been made in the diagnosis and treatment of cancer, several major issues remain unresolved. First, only a minority of patients respond to most forms of (chemo)therapy. It is generally believed that this poor responsiveness to drugs has its origin, at least in part, in the molecular heterogeneity of cancer. This heterogeneity requires the use of biomarkers to stratify patients having seemingly similar tumors according to their likely responses to specific cancer therapies. To identify such biomarkers, we will use large-scale genetic screens to identify genes that are causally involved in controlling responses to cancer drugs. Such genes are likely biomarkers of drug responsiveness in the clinic. Availability of such drug response biomarkers will facilitate a more personalized therapy choice for each individual patient. A second major deficit in effective cancer therapy is the lack of sufficient highly selective drug targets. The large-scale cancer genome re-sequencing efforts already indicate that there is a paucity of druggable genes that are consistently mutated in cancer and the same holds true for genes that are consistently over-expressed in cancer. Hence, there is an urgent need for innovative drug targets that have a similar cancer-selectivity as the genes that are specifically mutated or over-expressed in cancer. In this project, we will use large-scale loss of function genetic screens, exploiting the concept of synthetic lethality , to identify genes whose inactivation is selectively toxic to cells having a defined cancer-specific genetic alteration. Drugs against these targets will be highly cancer-selective, as their activity hinges on the presence of a specific genetic defect, which is only present in the cancer cell.
Summary
While significant progress has been made in the diagnosis and treatment of cancer, several major issues remain unresolved. First, only a minority of patients respond to most forms of (chemo)therapy. It is generally believed that this poor responsiveness to drugs has its origin, at least in part, in the molecular heterogeneity of cancer. This heterogeneity requires the use of biomarkers to stratify patients having seemingly similar tumors according to their likely responses to specific cancer therapies. To identify such biomarkers, we will use large-scale genetic screens to identify genes that are causally involved in controlling responses to cancer drugs. Such genes are likely biomarkers of drug responsiveness in the clinic. Availability of such drug response biomarkers will facilitate a more personalized therapy choice for each individual patient. A second major deficit in effective cancer therapy is the lack of sufficient highly selective drug targets. The large-scale cancer genome re-sequencing efforts already indicate that there is a paucity of druggable genes that are consistently mutated in cancer and the same holds true for genes that are consistently over-expressed in cancer. Hence, there is an urgent need for innovative drug targets that have a similar cancer-selectivity as the genes that are specifically mutated or over-expressed in cancer. In this project, we will use large-scale loss of function genetic screens, exploiting the concept of synthetic lethality , to identify genes whose inactivation is selectively toxic to cells having a defined cancer-specific genetic alteration. Drugs against these targets will be highly cancer-selective, as their activity hinges on the presence of a specific genetic defect, which is only present in the cancer cell.
Max ERC Funding
2 176 000 €
Duration
Start date: 2010-06-01, End date: 2015-05-31