Project acronym FatemapB
Project High Resolution Mapping of Fetal and Adult B Cell Fates During Ontogeny
Researcher (PI) Joan YUAN
Host Institution (HI) LUNDS UNIVERSITET
Call Details Starting Grant (StG), LS6, ERC-2016-STG
Summary FateMapB aims to understand how the unique differentiation potential of fetal hematopoietic stem and progenitor cells
(HSPCs) contribute to functionally distinct cell types of the adult immune system. While most immune cells are replenished
by HSPCs through life, others emerge during a limited window in fetal life and sustain through self-renewal in situ. The
lineage identity of fetal HSPCs, and the extent of their contribution to the adult immune repertoire remain surprisingly
unclear. I previously identified the fetal specific RNA binding protein Lin28b as a post-transcriptional molecular switch
capable of inducing fetal-like hematopoiesis in adult bone marrow HSPCs (Yuan et al. Science, 2012). This discovery has
afforded me with unique perspectives on the formation of the mammalian immune system. The concept that the mature
immune system is a mosaic of fetal and adult derived cell types is addressed herein with an emphasis on the B cell lineage.
We will use two complementary lineage-tracing technologies to stratify the immune system as a function of developmental
time, generating fundamental insight into the division of labor between fetal and adult HSPCs that ultimately provides
effective host protection.
Aim 1. Determine the qualitative and quantitative contribution of fetal HSPCs to the mature immune repertoire in situ
through Cre recombination mediated lineage-tracing.
Aim 2. Resolve the disputed lineage relationship between fetal derived B1a cells and adult derived B2 cells by single cell
lineage-tracing using cellular barcoding in vivo.
Aim 3. Characterize the mechanism and effector functions of Lin28b induced B1a cell development for assessing the
clinical utility of inducible fetal-like lymphopoiesis.
The implications of FateMapB extend beyond normal development to immune regeneration and age-related features of
leukemogenesis. Finally, our combinatorial lineage-tracing approach enables dissection of cell fates with previously
unattainable resolution.
Summary
FateMapB aims to understand how the unique differentiation potential of fetal hematopoietic stem and progenitor cells
(HSPCs) contribute to functionally distinct cell types of the adult immune system. While most immune cells are replenished
by HSPCs through life, others emerge during a limited window in fetal life and sustain through self-renewal in situ. The
lineage identity of fetal HSPCs, and the extent of their contribution to the adult immune repertoire remain surprisingly
unclear. I previously identified the fetal specific RNA binding protein Lin28b as a post-transcriptional molecular switch
capable of inducing fetal-like hematopoiesis in adult bone marrow HSPCs (Yuan et al. Science, 2012). This discovery has
afforded me with unique perspectives on the formation of the mammalian immune system. The concept that the mature
immune system is a mosaic of fetal and adult derived cell types is addressed herein with an emphasis on the B cell lineage.
We will use two complementary lineage-tracing technologies to stratify the immune system as a function of developmental
time, generating fundamental insight into the division of labor between fetal and adult HSPCs that ultimately provides
effective host protection.
Aim 1. Determine the qualitative and quantitative contribution of fetal HSPCs to the mature immune repertoire in situ
through Cre recombination mediated lineage-tracing.
Aim 2. Resolve the disputed lineage relationship between fetal derived B1a cells and adult derived B2 cells by single cell
lineage-tracing using cellular barcoding in vivo.
Aim 3. Characterize the mechanism and effector functions of Lin28b induced B1a cell development for assessing the
clinical utility of inducible fetal-like lymphopoiesis.
The implications of FateMapB extend beyond normal development to immune regeneration and age-related features of
leukemogenesis. Finally, our combinatorial lineage-tracing approach enables dissection of cell fates with previously
unattainable resolution.
Max ERC Funding
1 499 905 €
Duration
Start date: 2017-10-01, End date: 2022-09-30
Project acronym GRETPOL
Project Greening the Poles: Science, the Environment, and the Creation of the Modern Arctic and Antarctic
Researcher (PI) Peder ROBERTS
Host Institution (HI) KUNGLIGA TEKNISKA HOEGSKOLAN
Call Details Starting Grant (StG), SH6, ERC-2016-STG
Summary This project investigates how and why environmental concerns have become so important to our conceptions of the polar regions today. Through a historical study of both the Arctic and Antarctic from 1945 to the turn of the past century, the project explores the connections between how environments are described - particularly through the natural sciences and economics - and the judgments made about how those environments should be administered. The key hypothesis of this project is that the process of describing an environment cannot be separated from the process of controlling and managing it. Changing perceptions of concepts such as development, ecological fragility, and wilderness have provided frames for describing and understanding the polar regions. Why has natural resource extraction been deemed appropriate (or even necessary) in some contexts, and wholly forbidden in others? Why did the concept of sustainable development become important during the 1980s? Can we think of scientific research programs as instruments of colonialism? And why did national parks and conservation agreements become politically useful? GRETPOL will produce a new understanding of how far from being the passive frames for human action, environments (in the polar regions but indeed also beyond) are constructed by human agency. As anthropogenic climate change reduces polar ice extent and threatens the entire globe, the question has never been timelier.
Summary
This project investigates how and why environmental concerns have become so important to our conceptions of the polar regions today. Through a historical study of both the Arctic and Antarctic from 1945 to the turn of the past century, the project explores the connections between how environments are described - particularly through the natural sciences and economics - and the judgments made about how those environments should be administered. The key hypothesis of this project is that the process of describing an environment cannot be separated from the process of controlling and managing it. Changing perceptions of concepts such as development, ecological fragility, and wilderness have provided frames for describing and understanding the polar regions. Why has natural resource extraction been deemed appropriate (or even necessary) in some contexts, and wholly forbidden in others? Why did the concept of sustainable development become important during the 1980s? Can we think of scientific research programs as instruments of colonialism? And why did national parks and conservation agreements become politically useful? GRETPOL will produce a new understanding of how far from being the passive frames for human action, environments (in the polar regions but indeed also beyond) are constructed by human agency. As anthropogenic climate change reduces polar ice extent and threatens the entire globe, the question has never been timelier.
Max ERC Funding
1 499 952 €
Duration
Start date: 2017-02-01, End date: 2022-01-31
Project acronym LACOLA
Project Language, cognition and landscape: understanding cross-cultural and individual variation in geographical ontology
Researcher (PI) Niclas Burenhult
Host Institution (HI) LUNDS UNIVERSITET
Call Details Starting Grant (StG), SH4, ERC-2010-StG_20091209
Summary This project will break new ground in the language sciences by pursuing a linguistic inquiry into landscape. From the linguist s point of view, the geophysical environment is virtually unexplored. Yet it has vast potential for influence on the discipline. The project will play a pioneering role in situating landscape within linguistics as a fundamental domain of representational systems, opening up important links to other disciplines concerned with landscape that usually have little to do with language. It will achieve this by (1) exploring landscape categorization in a number of languages, (2) comparing such categorization, (3) developing a model for understanding categorization across languages and speakers, and (4) documenting vanishing landscape systems. The research team will study landscape categorization in six diverse language settings. Each setting is a case study carried out by a team member with expert knowledge and prior field experience of the setting. Each setting offers opportunities of studying closely related languages as well as individuals speaking the same language, making comparison possible not only among maximally diverse languages but also at finer levels of linguistic granularity. An exploratory psycholinguistic subproject will probe the relationship between language and cognition in the landscape domain. The project will blaze a trail in applying GIS to linguistic data, in testing advanced experimental techniques in the field, and in documenting domain-specific data from a global language sample. Cross-cultural variation in landscape ontology is a matter of great practical importance understanding the meaning and reference of landscape terms and place names is crucial to major fields of human cooperation, from navigation to international law.
Summary
This project will break new ground in the language sciences by pursuing a linguistic inquiry into landscape. From the linguist s point of view, the geophysical environment is virtually unexplored. Yet it has vast potential for influence on the discipline. The project will play a pioneering role in situating landscape within linguistics as a fundamental domain of representational systems, opening up important links to other disciplines concerned with landscape that usually have little to do with language. It will achieve this by (1) exploring landscape categorization in a number of languages, (2) comparing such categorization, (3) developing a model for understanding categorization across languages and speakers, and (4) documenting vanishing landscape systems. The research team will study landscape categorization in six diverse language settings. Each setting is a case study carried out by a team member with expert knowledge and prior field experience of the setting. Each setting offers opportunities of studying closely related languages as well as individuals speaking the same language, making comparison possible not only among maximally diverse languages but also at finer levels of linguistic granularity. An exploratory psycholinguistic subproject will probe the relationship between language and cognition in the landscape domain. The project will blaze a trail in applying GIS to linguistic data, in testing advanced experimental techniques in the field, and in documenting domain-specific data from a global language sample. Cross-cultural variation in landscape ontology is a matter of great practical importance understanding the meaning and reference of landscape terms and place names is crucial to major fields of human cooperation, from navigation to international law.
Max ERC Funding
1 499 931 €
Duration
Start date: 2011-03-01, End date: 2016-02-29
Project acronym PASSIM
Project Patents as Scientific Information, 1895-2020
Researcher (PI) Eva Susan Margareta HEMMUNGS WIRTÉN
Host Institution (HI) LINKOPINGS UNIVERSITET
Call Details Advanced Grant (AdG), SH6, ERC-2016-ADG
Summary “History will remember Barack Obama as the great Slayer of Patent Trolls.” The headline from the 2014 March 20 issue of Wired credits POTUS with, perhaps, an unexpected feat. Referring to companies in the sole business of enforcing patents beyond their actual value, trolls are a recent installment in the history of an intellectual property whose ubiquitousness the Latin word PASSIM (“here and there, everywhere”) neatly captures. In the eye of the storm stands the patent bargain: disclosure of information in return for a limited monopoly. This contractual moment makes patents a source of information, the basis of new innovation. Or does it? By posing this simple question, PASSIM’s bold take on the legitimacy of intellectual property in the governance of informational resources follow patents as legal and informational documents during three historical “patent phases,” producing a visionary and theoretically savvy interpretation of intellectual property that stems from its humanities-based and interdisciplinary project design. PASSIM shows a way out of current analytical gridlocks that earmark the understanding of the role of intellectual property in knowledge infrastructures—most notably the enclosure/openness dichotomy—and provides a fresh take on the complexity of informational processes. A key steppingstone in the PI’s career, her own contribution to PASSIM will be a work of synthesis, highlighting major tendencies in the history of patents as scientific information from 1895 to the present. Four complementary empirical studies target specific themes that strengthen PASSIM’s validity and impact: questions of copyrights in patents, scientists’ patenting strategies both historically and today, the relationship between bibliometrics and patentometrics, and the status of the patent as a legal and informational document. Outputs include workshops, articles, monographs, policy papers and documentation of the project’s experiences with interdisciplinary self-reflexivity.
Summary
“History will remember Barack Obama as the great Slayer of Patent Trolls.” The headline from the 2014 March 20 issue of Wired credits POTUS with, perhaps, an unexpected feat. Referring to companies in the sole business of enforcing patents beyond their actual value, trolls are a recent installment in the history of an intellectual property whose ubiquitousness the Latin word PASSIM (“here and there, everywhere”) neatly captures. In the eye of the storm stands the patent bargain: disclosure of information in return for a limited monopoly. This contractual moment makes patents a source of information, the basis of new innovation. Or does it? By posing this simple question, PASSIM’s bold take on the legitimacy of intellectual property in the governance of informational resources follow patents as legal and informational documents during three historical “patent phases,” producing a visionary and theoretically savvy interpretation of intellectual property that stems from its humanities-based and interdisciplinary project design. PASSIM shows a way out of current analytical gridlocks that earmark the understanding of the role of intellectual property in knowledge infrastructures—most notably the enclosure/openness dichotomy—and provides a fresh take on the complexity of informational processes. A key steppingstone in the PI’s career, her own contribution to PASSIM will be a work of synthesis, highlighting major tendencies in the history of patents as scientific information from 1895 to the present. Four complementary empirical studies target specific themes that strengthen PASSIM’s validity and impact: questions of copyrights in patents, scientists’ patenting strategies both historically and today, the relationship between bibliometrics and patentometrics, and the status of the patent as a legal and informational document. Outputs include workshops, articles, monographs, policy papers and documentation of the project’s experiences with interdisciplinary self-reflexivity.
Max ERC Funding
2 261 523 €
Duration
Start date: 2017-10-01, End date: 2022-09-30
Project acronym RNANTIBIOTICS
Project RNA-mediated virulence gene regulation: Identification of novel antibacterial compounds
Researcher (PI) Jan Jörgen Johansson
Host Institution (HI) UMEA UNIVERSITET
Call Details Starting Grant (StG), LS6, ERC-2010-StG_20091118
Summary All kingdoms possess a large fraction of RNA-based regulation. We identified several small non-coding regulatory RNAs (ncRNAs) in the human bacterial pathogen Listeria monocytogenes that controlled virulence by a direct RNA:RNA interaction. My group have also identified several 5´-untranslated RNAs (5´-UTRs) known to control expression of their downstream mRNA by a switch mechanism triggered by certain metabolites, specific compartments of the host or by different temperatures.
In the suggested project, we will analyze the mechanism by how various RNA-species function on a molecular level by biochemical and genetic approaches. By constructing mutations (deletion and base-substitutions), the role of the regulatory RNAs and their targets during pathogenesis will be pin-pointed using different virulence model organisms. For 5´-UTRs binding specific metabolites, we will add non-metabolic analogs to examine if such molecules can block the function of the 5´-UTRs and hence infection. The core structure of one identified ncRNA will be used as a scaffold to develop an RNA interference system in bacteria.
At least one RNA-helicase has been shown to be essential for bacterial motility and growth at 4°C. It is being purified to test its in vitro properties at mRNA targets and at different temperatures. Its in vivo role will be analyzed by genetic techniques.
Bacterial resistance against different antibiotics is an increasing problem worldwide. We have identified one pyridine molecule specifically targeting listerial virulence gene expression and its mechanism of action will be revealed by genetic and biochemical techniques. A diffusible, although yet unknown molecule, with bacteriostatic activity was observed and its nature and mechanism will be revealed mainly by biochemical experiments.
Our work will give important knowledge of how the bacterium uses RNA to sense its surroundings, but will also identifiy new types of antibacterial agents.
Summary
All kingdoms possess a large fraction of RNA-based regulation. We identified several small non-coding regulatory RNAs (ncRNAs) in the human bacterial pathogen Listeria monocytogenes that controlled virulence by a direct RNA:RNA interaction. My group have also identified several 5´-untranslated RNAs (5´-UTRs) known to control expression of their downstream mRNA by a switch mechanism triggered by certain metabolites, specific compartments of the host or by different temperatures.
In the suggested project, we will analyze the mechanism by how various RNA-species function on a molecular level by biochemical and genetic approaches. By constructing mutations (deletion and base-substitutions), the role of the regulatory RNAs and their targets during pathogenesis will be pin-pointed using different virulence model organisms. For 5´-UTRs binding specific metabolites, we will add non-metabolic analogs to examine if such molecules can block the function of the 5´-UTRs and hence infection. The core structure of one identified ncRNA will be used as a scaffold to develop an RNA interference system in bacteria.
At least one RNA-helicase has been shown to be essential for bacterial motility and growth at 4°C. It is being purified to test its in vitro properties at mRNA targets and at different temperatures. Its in vivo role will be analyzed by genetic techniques.
Bacterial resistance against different antibiotics is an increasing problem worldwide. We have identified one pyridine molecule specifically targeting listerial virulence gene expression and its mechanism of action will be revealed by genetic and biochemical techniques. A diffusible, although yet unknown molecule, with bacteriostatic activity was observed and its nature and mechanism will be revealed mainly by biochemical experiments.
Our work will give important knowledge of how the bacterium uses RNA to sense its surroundings, but will also identifiy new types of antibacterial agents.
Max ERC Funding
999 996 €
Duration
Start date: 2010-10-01, End date: 2015-09-30
Project acronym SeaLiT
Project Seafaring Lives in Transition. Mediterranean Maritime Labour and Shipping during Globalization, 1850s-1920s.
Researcher (PI) Apostolos Delis
Host Institution (HI) IDRYMA TECHNOLOGIAS KAI EREVNAS
Call Details Starting Grant (StG), SH6, ERC-2016-STG
Summary SeaLiT explores the transition from sail to steam navigation and its effects on seafaring populations in the Mediterranean and the Black Sea between the 1850s and the 1920s. In the core of the project lie the effects of technological innovation on seafaring people and maritime communities, whose lives were drastically altered by the advent of steam. The project addresses the changes through the actors, seafarers, shipowners and their families, focusing on the adjustment of seafaring lives to a novel socio-economic reality. It investigates the maritime labour market, the evolving relations among shipowner, captain, crew and their local societies, life on board and ashore, as well as the development of new business strategies, trade routes and navigation patterns.
Maritime labour and shipping remains an understudied case of the transition from the premodern working environment of the sailing ship to that of the steamer, in a period of rapid technological improvements, economic growth and market integration. Therefore, the project will address a major gap in maritime historiography: on the one hand, the transition from sail to steam, and on the other, the Mediterranean and the Black Sea, “the extended Mediterranean” according to F. Braudel.
The project examines in a comparative approach seven maritime regions: the Ionian, Aegean, Tyrrhenian, Adriatic and Black Seas, Spain and southern France. The research team composed of the PI, three postdoctoral fellows, four senior researchers and four Ph.D. candidates from Greece, Italy, Spain, France and Ukraine will study unpublished sources: ship logbooks, crew lists, business records, and private correspondence. They will produce a collective volume, several articles, a final synthesis by the PI, four Ph.D. dissertations, three workshops, one international conference and a website with an online open access database, an archival and bibliographical corpus and reconstruction of ship voyages on a web G.I.S. application.
Summary
SeaLiT explores the transition from sail to steam navigation and its effects on seafaring populations in the Mediterranean and the Black Sea between the 1850s and the 1920s. In the core of the project lie the effects of technological innovation on seafaring people and maritime communities, whose lives were drastically altered by the advent of steam. The project addresses the changes through the actors, seafarers, shipowners and their families, focusing on the adjustment of seafaring lives to a novel socio-economic reality. It investigates the maritime labour market, the evolving relations among shipowner, captain, crew and their local societies, life on board and ashore, as well as the development of new business strategies, trade routes and navigation patterns.
Maritime labour and shipping remains an understudied case of the transition from the premodern working environment of the sailing ship to that of the steamer, in a period of rapid technological improvements, economic growth and market integration. Therefore, the project will address a major gap in maritime historiography: on the one hand, the transition from sail to steam, and on the other, the Mediterranean and the Black Sea, “the extended Mediterranean” according to F. Braudel.
The project examines in a comparative approach seven maritime regions: the Ionian, Aegean, Tyrrhenian, Adriatic and Black Seas, Spain and southern France. The research team composed of the PI, three postdoctoral fellows, four senior researchers and four Ph.D. candidates from Greece, Italy, Spain, France and Ukraine will study unpublished sources: ship logbooks, crew lists, business records, and private correspondence. They will produce a collective volume, several articles, a final synthesis by the PI, four Ph.D. dissertations, three workshops, one international conference and a website with an online open access database, an archival and bibliographical corpus and reconstruction of ship voyages on a web G.I.S. application.
Max ERC Funding
1 372 350 €
Duration
Start date: 2017-02-01, End date: 2022-01-31
Project acronym SIMULTAN
Project Aging-related changes in brain activation and deactivation during cognition: novel insights into the physiology of the human mind from simultaneous PET-fMRI imaging
Researcher (PI) Anna RIECKMANN
Host Institution (HI) UMEA UNIVERSITET
Call Details Starting Grant (StG), SH4, ERC-2016-STG
Summary There is no doubt that functional magnetic resonance imaging (fMRI) has led to a breakthrough in our ability to measure how the complexities of the mind are rooted in biology. However, deactivation of certain brain areas during cognitive control and increased activation of prefrontal areas in aging are two examples of consistently found patterns of fMRI activation that have had a large impact on the study of the human mind, but that prompt major questions of interpretation. The physiological basis of the fMRI signal reflects interplay between hemodynamics and metabolic demands that vary across the brain, as well as between different tasks and individuals, and cannot be resolved by fMRI alone. To be able to use non-invasive imaging to distinguish a normally aging brain from one that is in the pre-clinical stages of disease, it is important to understand the neurobiological basis of these functional brain changes. Positron emission tomography (PET) is a molecular imaging method that is able to monitor brain glucose metabolism, which stems primarily from synaptic activity and is invariant to changes in blood flow. Studies that have made use of the complementary information gained from fMRI and PET to investigate human brain function have had to rely on sequential scans, and correlation of the signals from both modalities between individuals. The investigation of within-person switches between different mental states with complementary modalities is only made possible by the recent development of a hybrid PET-MR system, which, for the first time, allows simultaneous assessment of fMRI signal, blood flow and PET glucose metabolism during cognitive task performance. The proposal is structured in three work packages that include PET-fMRI scans in 30 healthy younger and 40 older adults. The analyses are designed to disentangle the hemodynamic and metabolic contributions to fMRI deactivations and prefrontal over-activation in aging during cognitive task performance.
Summary
There is no doubt that functional magnetic resonance imaging (fMRI) has led to a breakthrough in our ability to measure how the complexities of the mind are rooted in biology. However, deactivation of certain brain areas during cognitive control and increased activation of prefrontal areas in aging are two examples of consistently found patterns of fMRI activation that have had a large impact on the study of the human mind, but that prompt major questions of interpretation. The physiological basis of the fMRI signal reflects interplay between hemodynamics and metabolic demands that vary across the brain, as well as between different tasks and individuals, and cannot be resolved by fMRI alone. To be able to use non-invasive imaging to distinguish a normally aging brain from one that is in the pre-clinical stages of disease, it is important to understand the neurobiological basis of these functional brain changes. Positron emission tomography (PET) is a molecular imaging method that is able to monitor brain glucose metabolism, which stems primarily from synaptic activity and is invariant to changes in blood flow. Studies that have made use of the complementary information gained from fMRI and PET to investigate human brain function have had to rely on sequential scans, and correlation of the signals from both modalities between individuals. The investigation of within-person switches between different mental states with complementary modalities is only made possible by the recent development of a hybrid PET-MR system, which, for the first time, allows simultaneous assessment of fMRI signal, blood flow and PET glucose metabolism during cognitive task performance. The proposal is structured in three work packages that include PET-fMRI scans in 30 healthy younger and 40 older adults. The analyses are designed to disentangle the hemodynamic and metabolic contributions to fMRI deactivations and prefrontal over-activation in aging during cognitive task performance.
Max ERC Funding
1 499 544 €
Duration
Start date: 2017-06-01, End date: 2022-05-31
Project acronym THE RISE
Project Travels, transmissions and transformations in the 3rd and 2nd millennium BC in northern Europe: the rise of
Bronze Age societies
Researcher (PI) Kristian Kristiansen
Host Institution (HI) GOETEBORGS UNIVERSITET
Call Details Advanced Grant (AdG), SH6, ERC-2010-AdG_20100407
Summary Research problem: The 3rd and 2nd millennium was a period that saw major social and cultural transformations in Europe, from migrations and the introduction of metal (the Bronze Age) to new cultural identities and languages. As these two millennia were formative for Europe’s later history, these are hotly debated issues. However, they can now be resolved, at least in part, by the application of new science-based methodologies and the development of new interpretative frameworks.
Aims and methodologies: The project does so by adopting an interdisciplinary methodological approach that combines science and culture. Isotope tracing in combination with recent advances in ancient DNA is employed to test human origins and movements during the two millennia, as well as the origin of wool and textiles. Lead isotope is adopted to trace the origin of copper. Based on this the project will document and explain the forging of new identities and new types of interaction during the 3rd and 2nd millennium BC in temperate northern Europe, but with implications for western Eurasia.
Progress and originality: Accomplishment of front-line research results by combining archaeology with new developments in the natural sciences to produce new knowledge about the mobility of people, animals, things, ideas and technologies. This will allow a critical comparison of different types of evidence on mobility from DNA to strontium isotope analyses, and will lead to improved knowledge about the ways in which European regional cultures and identities were formed in the Bronze Age through interaction. Finally, the project will potentially change our understanding and thinking about human mobility as a key factor in cultural and social change.
Summary
Research problem: The 3rd and 2nd millennium was a period that saw major social and cultural transformations in Europe, from migrations and the introduction of metal (the Bronze Age) to new cultural identities and languages. As these two millennia were formative for Europe’s later history, these are hotly debated issues. However, they can now be resolved, at least in part, by the application of new science-based methodologies and the development of new interpretative frameworks.
Aims and methodologies: The project does so by adopting an interdisciplinary methodological approach that combines science and culture. Isotope tracing in combination with recent advances in ancient DNA is employed to test human origins and movements during the two millennia, as well as the origin of wool and textiles. Lead isotope is adopted to trace the origin of copper. Based on this the project will document and explain the forging of new identities and new types of interaction during the 3rd and 2nd millennium BC in temperate northern Europe, but with implications for western Eurasia.
Progress and originality: Accomplishment of front-line research results by combining archaeology with new developments in the natural sciences to produce new knowledge about the mobility of people, animals, things, ideas and technologies. This will allow a critical comparison of different types of evidence on mobility from DNA to strontium isotope analyses, and will lead to improved knowledge about the ways in which European regional cultures and identities were formed in the Bronze Age through interaction. Finally, the project will potentially change our understanding and thinking about human mobility as a key factor in cultural and social change.
Max ERC Funding
2 488 264 €
Duration
Start date: 2011-06-01, End date: 2016-05-31