Project acronym AACCT
Project Advanced Atmospheric Carbon Capture Technology
Researcher (PI) Wolfgang SCHMITT
Host Institution (HI) THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Country Ireland
Call Details Proof of Concept (PoC), ERC-2019-PoC
Summary Ever increasing atmospheric CO2 concentrations and global emissions of 36 Gt/year impose unprecedented threats to the world’s ecosystem and endanger industrial human activities in their entirety. This AACCT project will establish a new advanced technology that facilitates efficient CO2 capture from air and results in a commercial, stand-alone prototype that will demonstrate its economical and ecological viability, outperforming all other emerging approaches to atmospheric CO2 capture. The technology takes advantage of unique, intrinsic micro- and macro-molecular structures of porous materials that were developed within the ERC SUPRAMOL and Science Foundation Ireland funded projects. These adsorbents reveal extraordinary affinity to CO2, are non-corrosive, non-toxic and are based on stable, cheap and abundant silica materials. The system operates in moist air whereby the CO2 recovery is facilitated at mild conditions under which the adsorbent is regenerated. These intrinsic characteristics in combination with the macro-structure of sub-millimetre pellets that enhances the ad/desorption kinetics, results in exceptionally low operational CO2 capture costs. The technology is modular and the number of capture units scales linearly with the desired CO2 quantity. It is not restricted to fixed locations or CO2 point sources and thus, can conceptionally lead to negative or net zero CO2 emissions.
The AACCT technology will provide pure CO2 that can be sold, used or transformed within established or emerging chemical processes (i.e. methanol synthesis). Initially, it is envisaged that the systems, using low-grade waste heat, will be employed in energy-intensive industrial sectors requiring air circulation and cooling devices. A very modest adaptation of the AACCT prototypes can facilitate the reduction of Ireland’s greenhouse gas emissions by >10%, thus highlighting the potential impact and scalability of the proposed technology at European and global levels.
Summary
Ever increasing atmospheric CO2 concentrations and global emissions of 36 Gt/year impose unprecedented threats to the world’s ecosystem and endanger industrial human activities in their entirety. This AACCT project will establish a new advanced technology that facilitates efficient CO2 capture from air and results in a commercial, stand-alone prototype that will demonstrate its economical and ecological viability, outperforming all other emerging approaches to atmospheric CO2 capture. The technology takes advantage of unique, intrinsic micro- and macro-molecular structures of porous materials that were developed within the ERC SUPRAMOL and Science Foundation Ireland funded projects. These adsorbents reveal extraordinary affinity to CO2, are non-corrosive, non-toxic and are based on stable, cheap and abundant silica materials. The system operates in moist air whereby the CO2 recovery is facilitated at mild conditions under which the adsorbent is regenerated. These intrinsic characteristics in combination with the macro-structure of sub-millimetre pellets that enhances the ad/desorption kinetics, results in exceptionally low operational CO2 capture costs. The technology is modular and the number of capture units scales linearly with the desired CO2 quantity. It is not restricted to fixed locations or CO2 point sources and thus, can conceptionally lead to negative or net zero CO2 emissions.
The AACCT technology will provide pure CO2 that can be sold, used or transformed within established or emerging chemical processes (i.e. methanol synthesis). Initially, it is envisaged that the systems, using low-grade waste heat, will be employed in energy-intensive industrial sectors requiring air circulation and cooling devices. A very modest adaptation of the AACCT prototypes can facilitate the reduction of Ireland’s greenhouse gas emissions by >10%, thus highlighting the potential impact and scalability of the proposed technology at European and global levels.
Max ERC Funding
150 000 €
Duration
Start date: 2019-10-01, End date: 2021-09-30
Project acronym ACHIEVE
Project Advanced Cellular Hierarchical Tissue-Imitations based on Excluded Volume Effect
Researcher (PI) Dimitrios ZEVGOLIS
Host Institution (HI) NATIONAL UNIVERSITY OF IRELAND GALWAY
Country Ireland
Call Details Consolidator Grant (CoG), PE8, ERC-2019-COG
Summary ACHIEVE focuses on the application of Excluded Volume Effect in cell culture systems in order to enhance Extracellular Matrix (ECM) deposition. It represents a new horizon in in vitro cell culture which will address major challenges in medical advancement and food security. ACHIEVE will elucidate extracellular processes which occur during tissue generation, identifying favourable conditions for optimum tissue cultivation in vitro. These results will be applied in the diverse fields of regenerative medicine, drug discovery and cellular agriculture which all require advancements in in vitro tissue engineering to overcome current bottlenecks. Effective in vitro tissue culture is currently limited by lengthy culture periods. An inability to maintain physiologic (in vivo) conditions during this lengthy in vitro culture leads to cellular phenotype drift, ultimately resulting in generation of an undesired tissue. Enhanced tissue generation in vitro will greatly reduce culture times and costs, effecting improved in vitro tissue substitutes which remain true to their original phenotype. The research will be addressed under four work-packages. WP1 will investigate biochemical, biophysical and biological responses to varying culture conditions; WP 2, 3 and 4 will apply results in the fields of Tissue Engineering, Drug Discovery and Cellular Agriculture respectively. Research will involve extensive characterisation of derived- and stem-cell cultures in varying conditions of expansion and relevant health and safety and preclinical testing. The five year programme will be undertaken at the National University of Ireland, Galway, a centre of excellence in tissue engineering research, at a cost of € 2,439,270.
Summary
ACHIEVE focuses on the application of Excluded Volume Effect in cell culture systems in order to enhance Extracellular Matrix (ECM) deposition. It represents a new horizon in in vitro cell culture which will address major challenges in medical advancement and food security. ACHIEVE will elucidate extracellular processes which occur during tissue generation, identifying favourable conditions for optimum tissue cultivation in vitro. These results will be applied in the diverse fields of regenerative medicine, drug discovery and cellular agriculture which all require advancements in in vitro tissue engineering to overcome current bottlenecks. Effective in vitro tissue culture is currently limited by lengthy culture periods. An inability to maintain physiologic (in vivo) conditions during this lengthy in vitro culture leads to cellular phenotype drift, ultimately resulting in generation of an undesired tissue. Enhanced tissue generation in vitro will greatly reduce culture times and costs, effecting improved in vitro tissue substitutes which remain true to their original phenotype. The research will be addressed under four work-packages. WP1 will investigate biochemical, biophysical and biological responses to varying culture conditions; WP 2, 3 and 4 will apply results in the fields of Tissue Engineering, Drug Discovery and Cellular Agriculture respectively. Research will involve extensive characterisation of derived- and stem-cell cultures in varying conditions of expansion and relevant health and safety and preclinical testing. The five year programme will be undertaken at the National University of Ireland, Galway, a centre of excellence in tissue engineering research, at a cost of € 2,439,270.
Max ERC Funding
2 076 770 €
Duration
Start date: 2020-09-01, End date: 2025-08-31
Project acronym AncestralWeave
Project 1,000 ancient genomes: gene-economy innovation in cattle, sheep and goat
Researcher (PI) Daniel BRADLEY
Host Institution (HI) THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Country Ireland
Call Details Advanced Grant (AdG), SH6, ERC-2019-ADG
Summary The genetic threads of goat, cattle and sheep ancestry have been woven by human breeding, environmental pressures, hybridisation and the chance effects of genetic drift. The ancestral weaves of these key animals intertwine with human creativity in the most profoundly innovative episodes of the human past. Three broad episodes of particular import were: initial domestications circa 11 kya in Southwest Asia; the intensification circa 6 kya of use of those animal products which are harvested without killing such as wool, milk and traction; and the development of exceptionally productive landraces, later formalized into breeds, in recent millennia. However, each of these is loosely defined in time and space, the key traits are often osteologically invisible, and the vectors of causality in their virtuous cycles of gene-economy innovation are completely unknown.
A combination of high coverage ancient whole genome data coupled with new analysis methods that allow efficient computation of genomewide locus genealogies will be used to untangle the threads of ancestry in sheep, cattle and goat across the whole genome in these transformative phases. Combining these with additional low coverage genomes generated from less preserved samples will generate a total set of 1,000 ancient animal genomes. These data will be unprecedented and will allow tracking of selection at trait genes, in order to detect human agency in breeding and, in collaboration with archaeologist partners, asking are there periods and places where threads of innovation coalesce. The project will also use ancient epigenetics to explore archaeological variation in gene activation patterns and will seek to understand the problematic build up of harmful mutations that threaten livestock today. With cognate disciplines, it will compare signals of animal mobility identifying distinct genetic strata correlating with archaeological horizons and affording the prospect of DNA-dating in future excavation.
Summary
The genetic threads of goat, cattle and sheep ancestry have been woven by human breeding, environmental pressures, hybridisation and the chance effects of genetic drift. The ancestral weaves of these key animals intertwine with human creativity in the most profoundly innovative episodes of the human past. Three broad episodes of particular import were: initial domestications circa 11 kya in Southwest Asia; the intensification circa 6 kya of use of those animal products which are harvested without killing such as wool, milk and traction; and the development of exceptionally productive landraces, later formalized into breeds, in recent millennia. However, each of these is loosely defined in time and space, the key traits are often osteologically invisible, and the vectors of causality in their virtuous cycles of gene-economy innovation are completely unknown.
A combination of high coverage ancient whole genome data coupled with new analysis methods that allow efficient computation of genomewide locus genealogies will be used to untangle the threads of ancestry in sheep, cattle and goat across the whole genome in these transformative phases. Combining these with additional low coverage genomes generated from less preserved samples will generate a total set of 1,000 ancient animal genomes. These data will be unprecedented and will allow tracking of selection at trait genes, in order to detect human agency in breeding and, in collaboration with archaeologist partners, asking are there periods and places where threads of innovation coalesce. The project will also use ancient epigenetics to explore archaeological variation in gene activation patterns and will seek to understand the problematic build up of harmful mutations that threaten livestock today. With cognate disciplines, it will compare signals of animal mobility identifying distinct genetic strata correlating with archaeological horizons and affording the prospect of DNA-dating in future excavation.
Max ERC Funding
2 499 199 €
Duration
Start date: 2020-12-01, End date: 2025-11-30
Project acronym APCG
Project Arabic Poetry in the Cairo Genizah
Researcher (PI) Mohamed Ali Hussein Ahmed
Host Institution (HI) THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Country Ireland
Call Details Starting Grant (StG), SH5, ERC-2019-STG
Summary Poetry enjoys a special place in Arabic culture and literature. For centuries, Arabs of all faiths have considered poetry a key source for knowledge, intellectuality and wisdom. In the pre-Islamic era, poetry was considered as ‘the Arab knowledge’ and ‘the Arab cultural archive’, in which the social and cultural history, language, arts, music, religious and Arab’s human experience were stored and preserved. Being a part of Arabic culture, Jews of Arab lands equally enjoyed writing and reading poetry. APCG will investigate for the first time a hitherto neglected collection of Arabic poetry fragments written in Hebrew script (in Judaeo-Arabic), which has been preserved in arguably the most important Jewish treasure trove: the Cairo Genizah. The fragments, numbered in the hundreds, constitute a unique source for understanding medieval and Early Modern Egypt from three main perspectives: Arabic studies, Jewish social and cultural studies, and anthropological studies.
The core aims of the project are:
• to make the entirety of Arabic and Judaeo-Arabic poetry in the Cairo Genizah accessible to both academic scholars and to the public in a comprehensive database and in critical editions;
• to reveal, through the study of poetry, hitherto hidden aspects of social and cultural history of the Jews in the Middle East with regard to literacy, education and intercommunal relations;
• to explore hierarchies, interpersonal relationships and the social function of poetry in medieval and early modern Egypt through the study of Genizah poetry.
To achieve the planned main objectives, APCG carries out a thorough interdisciplinary study of Genizah’s Arabic poetry. This approach involves research from philological, linguistic, literary, historical and anthropological perspectives.
Summary
Poetry enjoys a special place in Arabic culture and literature. For centuries, Arabs of all faiths have considered poetry a key source for knowledge, intellectuality and wisdom. In the pre-Islamic era, poetry was considered as ‘the Arab knowledge’ and ‘the Arab cultural archive’, in which the social and cultural history, language, arts, music, religious and Arab’s human experience were stored and preserved. Being a part of Arabic culture, Jews of Arab lands equally enjoyed writing and reading poetry. APCG will investigate for the first time a hitherto neglected collection of Arabic poetry fragments written in Hebrew script (in Judaeo-Arabic), which has been preserved in arguably the most important Jewish treasure trove: the Cairo Genizah. The fragments, numbered in the hundreds, constitute a unique source for understanding medieval and Early Modern Egypt from three main perspectives: Arabic studies, Jewish social and cultural studies, and anthropological studies.
The core aims of the project are:
• to make the entirety of Arabic and Judaeo-Arabic poetry in the Cairo Genizah accessible to both academic scholars and to the public in a comprehensive database and in critical editions;
• to reveal, through the study of poetry, hitherto hidden aspects of social and cultural history of the Jews in the Middle East with regard to literacy, education and intercommunal relations;
• to explore hierarchies, interpersonal relationships and the social function of poetry in medieval and early modern Egypt through the study of Genizah poetry.
To achieve the planned main objectives, APCG carries out a thorough interdisciplinary study of Genizah’s Arabic poetry. This approach involves research from philological, linguistic, literary, historical and anthropological perspectives.
Max ERC Funding
1 456 246 €
Duration
Start date: 2020-07-01, End date: 2025-06-30
Project acronym DANCING
Project Protecting the Right to Culture of Persons with Disabilities and Enhancing Cultural Diversity through European Union Law: Exploring New Paths
Researcher (PI) Delia Ferri
Host Institution (HI) NATIONAL UNIVERSITY OF IRELAND MAYNOOTH
Country Ireland
Call Details Consolidator Grant (CoG), SH2, ERC-2019-COG
Summary The right of people with disabilities to participate in cultural life - which encompasses the rights of access to, and to be involved in cultural activities, as well as the recognition of disability identities, such as Deaf culture – has been for long denied. The cultural exclusion of disabled people has engendered their marginalisation. It has also entailed a loss for society as a whole, because of the lack of cultural diversity resulting from an inaccessible and exclusionary cultural realm. DANCING will investigate the extent to which the protection of the right to take part in culture of people with disabilities and the promotion of cultural diversity intersect and complement each other in the European Union (EU) legal order. It will disrupt the conventional approach adopted by EU law scholarship by using a combination of legal, empirical and arts-based research to pursue three complementary objectives, experiential, normative and theoretical respectively. First, it will identify and categorise barriers and facilitators to cultural participation experienced by disabled people and how they affect the wider cultural domain. Secondly, it will provide a normative exploration of how the EU has used and can use its competence to combat discrimination and its supporting competence on cultural matters, in synergy with its wide internal market powers, to ensure the accessibility of cultural activities, to promote disability identities, while achieving cultural diversity. In doing so, it will bridge, in an unprecedented way, the implementation of the UN Convention on the Rights of Persons with Disabilities and the UNESCO Convention on the Protection and Promotion of the Diversity of Cultural Expressions. Thirdly, it will advance the understanding of the legal concept of cultural diversity, which stems from the intersection of different sources of law, and will propose a new theorization of the promotion of cultural diversity within the EU legal order.
Summary
The right of people with disabilities to participate in cultural life - which encompasses the rights of access to, and to be involved in cultural activities, as well as the recognition of disability identities, such as Deaf culture – has been for long denied. The cultural exclusion of disabled people has engendered their marginalisation. It has also entailed a loss for society as a whole, because of the lack of cultural diversity resulting from an inaccessible and exclusionary cultural realm. DANCING will investigate the extent to which the protection of the right to take part in culture of people with disabilities and the promotion of cultural diversity intersect and complement each other in the European Union (EU) legal order. It will disrupt the conventional approach adopted by EU law scholarship by using a combination of legal, empirical and arts-based research to pursue three complementary objectives, experiential, normative and theoretical respectively. First, it will identify and categorise barriers and facilitators to cultural participation experienced by disabled people and how they affect the wider cultural domain. Secondly, it will provide a normative exploration of how the EU has used and can use its competence to combat discrimination and its supporting competence on cultural matters, in synergy with its wide internal market powers, to ensure the accessibility of cultural activities, to promote disability identities, while achieving cultural diversity. In doing so, it will bridge, in an unprecedented way, the implementation of the UN Convention on the Rights of Persons with Disabilities and the UNESCO Convention on the Protection and Promotion of the Diversity of Cultural Expressions. Thirdly, it will advance the understanding of the legal concept of cultural diversity, which stems from the intersection of different sources of law, and will propose a new theorization of the promotion of cultural diversity within the EU legal order.
Max ERC Funding
1 999 337 €
Duration
Start date: 2020-09-01, End date: 2025-08-31
Project acronym DBScontrol
Project Implementation and preclinical testing of a closed-loop control system for deep brain stimulation
Researcher (PI) madeleine LOWERY
Host Institution (HI) UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Country Ireland
Call Details Proof of Concept (PoC), ERC-2019-PoC
Summary Over the past 25 years deep brain stimulation (DBS) has emerged as an effective treatment for the symptoms of Parkinson's disease (PD). Despite its success, the mechanisms of DBS are not yet fully understood. Moreover, patients experience side effects and poor control of symptoms associated with suboptimal programming of stimulus parameters. Current DBS systems operate in an 'open-loop' configuration with stimulus parameters (pulse amplitude, duration and frequency) empirically set and remaining fixed over time. Closed-loop DBS offers an alternative approach that has the potential to overcome current limitations and increase therapeutic efficacy, while reducing side-effects and increasing battery life, by automatically adjusting stimulation parameters as required. Although the potential benefits of closed-loop DBS are widely recognised, these systems have not yet been implemented clinically. Under the parent ERC project DBSmodel, we have developed biophysically detailed computational models of the neural circuits in the brain during DBS and are using these to develop and test novel algorithms for closed-loop DBS. Before these can be trialled in humans, however, feasibility must first to be demonstrated through implementation on a prototype device and pre-clinical testing in animal models. ERC proof of concept funding will enable us to do this by implementing and testing a novel closed-loop DBS system in an animal model of PD. The experimental validation will confirm the efficacy of a prototype solution suitable for translation to human studies.
Summary
Over the past 25 years deep brain stimulation (DBS) has emerged as an effective treatment for the symptoms of Parkinson's disease (PD). Despite its success, the mechanisms of DBS are not yet fully understood. Moreover, patients experience side effects and poor control of symptoms associated with suboptimal programming of stimulus parameters. Current DBS systems operate in an 'open-loop' configuration with stimulus parameters (pulse amplitude, duration and frequency) empirically set and remaining fixed over time. Closed-loop DBS offers an alternative approach that has the potential to overcome current limitations and increase therapeutic efficacy, while reducing side-effects and increasing battery life, by automatically adjusting stimulation parameters as required. Although the potential benefits of closed-loop DBS are widely recognised, these systems have not yet been implemented clinically. Under the parent ERC project DBSmodel, we have developed biophysically detailed computational models of the neural circuits in the brain during DBS and are using these to develop and test novel algorithms for closed-loop DBS. Before these can be trialled in humans, however, feasibility must first to be demonstrated through implementation on a prototype device and pre-clinical testing in animal models. ERC proof of concept funding will enable us to do this by implementing and testing a novel closed-loop DBS system in an animal model of PD. The experimental validation will confirm the efficacy of a prototype solution suitable for translation to human studies.
Max ERC Funding
150 000 €
Duration
Start date: 2020-03-02, End date: 2021-09-01
Project acronym EndoSolve
Project A novel medical device for the treatment of Endometriosis
Researcher (PI) Martin O'HALLORAN
Host Institution (HI) NATIONAL UNIVERSITY OF IRELAND GALWAY
Country Ireland
Call Details Proof of Concept (PoC), ERC-2019-PoC
Summary Endometriosis is one of the most prevalent, impactful and undertreated disorders to affect European women. The condition is defined as an estrogen-dependent disorder, where endometrial tissue forms lesions outside the uterus resulting in chronic pain and infertility. Endometriosis affects an estimated 10% of European women in the reproductive-age group (176 million women worldwide and 10.7 million in the EU) with significant impact on their physical, mental, and social well-being (This impact is exacerbated by the fact that the correct diagnosis is made as late as 8–11 years after symptom presentation. Treatment delays are due to a lack of a reliable non-invasive diagnostic test, and the fact that the reference diagnostic standard is laparoscopy (invasive, expensive and not without risks). As there is no permanent cure for endometriosis, current therapies have three main goals: (i) to reduce pain; (ii) to increase the pregnancy rate for women who desire to have children and (iii) to delay recurrence for as long as possible. The EndoSolve project will develop the first medical device to treat the underlying mechanism of endometriosis, providing a long-term non-pharma treatment for the chronic disease.
Summary
Endometriosis is one of the most prevalent, impactful and undertreated disorders to affect European women. The condition is defined as an estrogen-dependent disorder, where endometrial tissue forms lesions outside the uterus resulting in chronic pain and infertility. Endometriosis affects an estimated 10% of European women in the reproductive-age group (176 million women worldwide and 10.7 million in the EU) with significant impact on their physical, mental, and social well-being (This impact is exacerbated by the fact that the correct diagnosis is made as late as 8–11 years after symptom presentation. Treatment delays are due to a lack of a reliable non-invasive diagnostic test, and the fact that the reference diagnostic standard is laparoscopy (invasive, expensive and not without risks). As there is no permanent cure for endometriosis, current therapies have three main goals: (i) to reduce pain; (ii) to increase the pregnancy rate for women who desire to have children and (iii) to delay recurrence for as long as possible. The EndoSolve project will develop the first medical device to treat the underlying mechanism of endometriosis, providing a long-term non-pharma treatment for the chronic disease.
Max ERC Funding
150 000 €
Duration
Start date: 2021-01-01, End date: 2021-12-31
Project acronym EVEREST
Project Extracellular Vesicles for Bone Regeneration – alternatives to Stem-cell Therapy
Researcher (PI) meadhbh BRENNAN
Host Institution (HI) NATIONAL UNIVERSITY OF IRELAND GALWAY
Country Ireland
Call Details Starting Grant (StG), LS7, ERC-2019-STG
Summary The therapeutic benefits of mesenchymal stem cells (MSCs), the state-of-the-art treatment for healing bone defects following trauma, resection of cancerous bone tumors, or metabolic bone diseases, has been attributed to their secreted factors. The regenerative potential of MSC-secreted extracellular vesicles (EVs), nanoparticles which deliver bioactive cargo (nucleic acids, proteins, and lipids) between cells, has recently been reported. The applicant will embark upon frontier research with the objective of progressing beyond the state-of-the-art, by harnessing the therapeutic effects of MSCs, but in a cutting-edge, cell-free manner, by developing high potency EV-based bone replacements. This objective will be addressed by firstly testing novel hypotheses to delineate how culture environments, specifically mechanical cues (substrate elasticity and 3D dynamic), hypoxia, and cell stress can modulate the cargo of EVs secreted by MSC. Size exclusion chromatography, which separates EVs from soluble proteins will be employed. Heterogeneity of EV cargo and functionality between human MSC donors will also be evaluated. Answering these hypotheses will permit the intelligent design of targeted EV therapies. The hypothesis that EV-functionalized constructs, fabricated by 3D-printing, will lead to controlled and sustained release of EVs and induce bone formation in vivo will best tested. Together, this will answer critical questions, namely the most favorable environment for collection of potent EVs for regenerative medicine, which secretome component (EV, soluble factors) is responsible for bone regeneration, and whether MSC cell therapy can be replaced by cell-free EVs. EVEREST will develop a platform for targeted EV delivery in ground-breaking, easy to transport and handle, ‘off-the-shelf’ anatomically correct constructs, which have the potential to reduce pain by elimination of bone or bone marrow harvest, and revolutionize the treatment of bone defects.
Summary
The therapeutic benefits of mesenchymal stem cells (MSCs), the state-of-the-art treatment for healing bone defects following trauma, resection of cancerous bone tumors, or metabolic bone diseases, has been attributed to their secreted factors. The regenerative potential of MSC-secreted extracellular vesicles (EVs), nanoparticles which deliver bioactive cargo (nucleic acids, proteins, and lipids) between cells, has recently been reported. The applicant will embark upon frontier research with the objective of progressing beyond the state-of-the-art, by harnessing the therapeutic effects of MSCs, but in a cutting-edge, cell-free manner, by developing high potency EV-based bone replacements. This objective will be addressed by firstly testing novel hypotheses to delineate how culture environments, specifically mechanical cues (substrate elasticity and 3D dynamic), hypoxia, and cell stress can modulate the cargo of EVs secreted by MSC. Size exclusion chromatography, which separates EVs from soluble proteins will be employed. Heterogeneity of EV cargo and functionality between human MSC donors will also be evaluated. Answering these hypotheses will permit the intelligent design of targeted EV therapies. The hypothesis that EV-functionalized constructs, fabricated by 3D-printing, will lead to controlled and sustained release of EVs and induce bone formation in vivo will best tested. Together, this will answer critical questions, namely the most favorable environment for collection of potent EVs for regenerative medicine, which secretome component (EV, soluble factors) is responsible for bone regeneration, and whether MSC cell therapy can be replaced by cell-free EVs. EVEREST will develop a platform for targeted EV delivery in ground-breaking, easy to transport and handle, ‘off-the-shelf’ anatomically correct constructs, which have the potential to reduce pain by elimination of bone or bone marrow harvest, and revolutionize the treatment of bone defects.
Max ERC Funding
1 499 925 €
Duration
Start date: 2020-11-01, End date: 2025-10-31
Project acronym HERCULES
Project HEterodyne RefraCtive index sensor Using photonic crystal LaSers
Researcher (PI) John William Whelan-Curtin
Host Institution (HI) MUNSTER TECHNOLOGICAL UNIVERSITY
Country Ireland
Call Details Proof of Concept (PoC), ERC-2019-PoC
Summary In the HERCULES project, we will improve the refractive index detection limit by 3 orders of magnitude relative to the state of the art, by implementing an on-chip optical heterodyne measurement using one of the brand-new semiconductor lasers developed during the DANCER starting grant.
The detection limit (DL) is the key measure of the performance of a RI sensor and determines the smallest change in refractive index that a sensor can detect. The DL is a function of the RI sensitivity, which is the magnitude in shift of the resonant wavelength versus the change in RI of the sample, and of the sensor resolution, which characterizes the smallest possible spectral shift that can be accurately measured.
The laser uses a resonant mirror comprised of a 1D photonic crystal cavity. Approximately 40% of the mode supported by the 1D PhC exists in the cladding material (in this case, the air or water of the sample) meaning the lasing wavelength is strongly affected by the sample’s refractive index. The linewidth of the laser is on the order of Megahertz which is three orders of magnitude smaller than that of silicon ring resonators typically used for RI sensing.
Summary
In the HERCULES project, we will improve the refractive index detection limit by 3 orders of magnitude relative to the state of the art, by implementing an on-chip optical heterodyne measurement using one of the brand-new semiconductor lasers developed during the DANCER starting grant.
The detection limit (DL) is the key measure of the performance of a RI sensor and determines the smallest change in refractive index that a sensor can detect. The DL is a function of the RI sensitivity, which is the magnitude in shift of the resonant wavelength versus the change in RI of the sample, and of the sensor resolution, which characterizes the smallest possible spectral shift that can be accurately measured.
The laser uses a resonant mirror comprised of a 1D photonic crystal cavity. Approximately 40% of the mode supported by the 1D PhC exists in the cladding material (in this case, the air or water of the sample) meaning the lasing wavelength is strongly affected by the sample’s refractive index. The linewidth of the laser is on the order of Megahertz which is three orders of magnitude smaller than that of silicon ring resonators typically used for RI sensing.
Max ERC Funding
150 000 €
Duration
Start date: 2020-11-01, End date: 2022-04-30
Project acronym IndDecision
Project A neurally-informed behavioural modeling framework for examining individual and group difference in perceptual decision making
Researcher (PI) Redmond O'CONNELL
Host Institution (HI) THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Country Ireland
Call Details Consolidator Grant (CoG), SH4, ERC-2019-COG
Summary Pinpointing the mechanistic origins of inter-individual differences in decision making is a central goal of modern psychology and a considerable challenge because even elementary perceptual choices rely on a multitude of sensory, cognitive, motivational and motoric processes. For this reason, researchers have relied heavily on a set of mathematical ‘sequential sampling’ models that are designed to parse the latent psychological processes driving variations in choice behaviour. Although these models have been fruitfully employed in thousands of theoretical and neurophysiological investigations, they suffer from several limitations that particularly undermine their utility in inter-individual or -group comparisons including: A) parameter values are estimated on a relative, within-subject scale; B) the models come in many forms that can make identical behavioural predictions despite invoking fundamentally different mechanisms (‘model mimicry’); and C) they deal in abstract psychological constructs that are themselves dependent on multiple neural processes. The objective of this proposal is to address each of these issues by pioneering a ground-breaking decision modelling framework in which models are constructed and evaluated based on their ability to explain key observable aspects of the neural implementation of the human decision process in addition to its behavioural output. This ambitious goal is made possible by recent advances in non-invasive electrophysiology which enable direct observation, measurement and manipulation of the decision process as it unfolds in the human brain. Across a series of empirical investigations that will use adult aging as a test-bed for studying inter-individual and -group differences, this research will yield new methods for directly comparing model parameter values across subjects, resolve prominent theoretical debates regarding decision making algorithms and gain important new insights into their susceptibility to cognitive aging.
Summary
Pinpointing the mechanistic origins of inter-individual differences in decision making is a central goal of modern psychology and a considerable challenge because even elementary perceptual choices rely on a multitude of sensory, cognitive, motivational and motoric processes. For this reason, researchers have relied heavily on a set of mathematical ‘sequential sampling’ models that are designed to parse the latent psychological processes driving variations in choice behaviour. Although these models have been fruitfully employed in thousands of theoretical and neurophysiological investigations, they suffer from several limitations that particularly undermine their utility in inter-individual or -group comparisons including: A) parameter values are estimated on a relative, within-subject scale; B) the models come in many forms that can make identical behavioural predictions despite invoking fundamentally different mechanisms (‘model mimicry’); and C) they deal in abstract psychological constructs that are themselves dependent on multiple neural processes. The objective of this proposal is to address each of these issues by pioneering a ground-breaking decision modelling framework in which models are constructed and evaluated based on their ability to explain key observable aspects of the neural implementation of the human decision process in addition to its behavioural output. This ambitious goal is made possible by recent advances in non-invasive electrophysiology which enable direct observation, measurement and manipulation of the decision process as it unfolds in the human brain. Across a series of empirical investigations that will use adult aging as a test-bed for studying inter-individual and -group differences, this research will yield new methods for directly comparing model parameter values across subjects, resolve prominent theoretical debates regarding decision making algorithms and gain important new insights into their susceptibility to cognitive aging.
Max ERC Funding
1 996 310 €
Duration
Start date: 2021-01-01, End date: 2025-12-31
