Project acronym KnowStudents
Project From East to West, and Back Again: Student Travel and Transcultural Knowledge Production in Renaissance Europe (c. 1470- c. 1620)
Researcher (PI) Valentina LEPRI
Host Institution (HI) INSTYTUT FILOZOFII I SOCJOLOGII POLSKIEJ AKADEMII NAUK
Country Poland
Call Details Consolidator Grant (CoG), SH6, ERC-2019-COG
Summary This project is the first comprehensive study of transcultural knowledge production in early modern Europe. Its underpinning idea is that the students who travelled from central-eastern Europe to attend renowned universities were active agents of this transcultural knowledge. During their stays abroad they created personal hand-written notebooks containing lecture notes and any other texts that attracted their interest. Conserved in the archives of the Czech Republic, Hungary, Lithuania, Poland and Ukraine, these notebooks provide us with unique and first-hand documentary evidence of the impact of multiple cultural stimuli on knowledge. Combining intellectual history, history of migration and physical analysis of documents, the project will consider the period from the rise of this practice among students, due to an unprecedented availability of paper (c. 1470), up to the Thirty Years’ War, which restricted their travels. Its objectives are to analyse: the relationship between academic and non-academic knowledge gathered in the students’ notebooks; the emergence of new forms of self-learning, examining the criteria of text selection; and the contact between humanist culture and the cultures of the countries the students came from. Early modern studies of knowledge production have traditionally focused on academic teaching. Although the cosmopolitan nature of universities is an established fact in these studies, the impact of different cultures (languages, artistic-literary interests, religious practices) on knowledge creation has been neglected, due to lack of evidence. Students’ experience makes it possible to observe links between knowledge and a plurality of languages and traditions which best reflects the European scenario at the time. The project will explore knowledge creation from an unprecedented angle, fostering a rethinking of the notion of centre and peripheries in Renaissance studies and breaking important new ground for research on intellectual history.
Summary
This project is the first comprehensive study of transcultural knowledge production in early modern Europe. Its underpinning idea is that the students who travelled from central-eastern Europe to attend renowned universities were active agents of this transcultural knowledge. During their stays abroad they created personal hand-written notebooks containing lecture notes and any other texts that attracted their interest. Conserved in the archives of the Czech Republic, Hungary, Lithuania, Poland and Ukraine, these notebooks provide us with unique and first-hand documentary evidence of the impact of multiple cultural stimuli on knowledge. Combining intellectual history, history of migration and physical analysis of documents, the project will consider the period from the rise of this practice among students, due to an unprecedented availability of paper (c. 1470), up to the Thirty Years’ War, which restricted their travels. Its objectives are to analyse: the relationship between academic and non-academic knowledge gathered in the students’ notebooks; the emergence of new forms of self-learning, examining the criteria of text selection; and the contact between humanist culture and the cultures of the countries the students came from. Early modern studies of knowledge production have traditionally focused on academic teaching. Although the cosmopolitan nature of universities is an established fact in these studies, the impact of different cultures (languages, artistic-literary interests, religious practices) on knowledge creation has been neglected, due to lack of evidence. Students’ experience makes it possible to observe links between knowledge and a plurality of languages and traditions which best reflects the European scenario at the time. The project will explore knowledge creation from an unprecedented angle, fostering a rethinking of the notion of centre and peripheries in Renaissance studies and breaking important new ground for research on intellectual history.
Max ERC Funding
1 737 225 €
Duration
Start date: 2020-11-01, End date: 2025-10-31
Project acronym LABFER
Project Globalisation- and Technology-Driven Labour Market Change and Fertility
Researcher (PI) Anna MATYSIAK
Host Institution (HI) UNIWERSYTET WARSZAWSKI
Country Poland
Call Details Consolidator Grant (CoG), SH3, ERC-2019-COG
Summary LABFER is the first project that will LABFER is the first project that will comprehensively describe and evaluate fertility consequences of the unprecedented changes in the labour market, caused by digitalisation and globalisation. These changes have been taking place during the last three decades and intensified after the Great Recession. They are reflected in: rising demand for skills, massive worker displacement, spread of new work arrangements, increasing work demands and growing inequalities in labour market prospects between the low-and-medium and the highly skilled. They are likely driving the post-crisis fertility decline in the most advanced nations, which is to date not understood. LABFER is thus highly relevant and timely. It has four main objectives:
1) to study the impact of the ongoing labour market change on fertility (macro-level);
2) to examine the individual-level mechanisms behind the observed macro-level fertility effects of the ongoing labour market change;
3) to investigate the role of the growing inequalities between the low-and-medium and the highly skilled for the relative fertility patterns of the two groups;
4) to study the role of family and employment policies in moderating the fertility effects of the labour market change.
Our methodological approach is innovative. We will link data at several layers of observation (country, region, industry, firm, couple and individual) to account for the policy, work and family context of childbearing. We will also use novel labour market measures to capture the ongoing labour market change. Mixture cure models will be employed to separate the effects of covariates on birth timing and probability that the birth occurs.
LABFER will break the ground by providing understanding of how the dynamic labour market changes are associated with and potentially affect the current and future fertility dynamics and its socio-economic gradients. It will also have implications for family and employment policies.
Summary
LABFER is the first project that will LABFER is the first project that will comprehensively describe and evaluate fertility consequences of the unprecedented changes in the labour market, caused by digitalisation and globalisation. These changes have been taking place during the last three decades and intensified after the Great Recession. They are reflected in: rising demand for skills, massive worker displacement, spread of new work arrangements, increasing work demands and growing inequalities in labour market prospects between the low-and-medium and the highly skilled. They are likely driving the post-crisis fertility decline in the most advanced nations, which is to date not understood. LABFER is thus highly relevant and timely. It has four main objectives:
1) to study the impact of the ongoing labour market change on fertility (macro-level);
2) to examine the individual-level mechanisms behind the observed macro-level fertility effects of the ongoing labour market change;
3) to investigate the role of the growing inequalities between the low-and-medium and the highly skilled for the relative fertility patterns of the two groups;
4) to study the role of family and employment policies in moderating the fertility effects of the labour market change.
Our methodological approach is innovative. We will link data at several layers of observation (country, region, industry, firm, couple and individual) to account for the policy, work and family context of childbearing. We will also use novel labour market measures to capture the ongoing labour market change. Mixture cure models will be employed to separate the effects of covariates on birth timing and probability that the birth occurs.
LABFER will break the ground by providing understanding of how the dynamic labour market changes are associated with and potentially affect the current and future fertility dynamics and its socio-economic gradients. It will also have implications for family and employment policies.
Max ERC Funding
1 998 100 €
Duration
Start date: 2020-10-01, End date: 2025-09-30
Project acronym MitoRepairosome
Project Dissecting the mechanism of DNA repair in human mitochondria
Researcher (PI) Michal Szymanski
Host Institution (HI) UNIWERSYTET GDANSKI
Country Poland
Call Details Starting Grant (StG), LS1, ERC-2019-STG
Summary In mammalian cells genetic information is stored in two compartments: in the nucleus and in the mitochondria. DNA in mitochondria (mtDNA), just like in theIn mammalian cells genetic information is stored in two locations: in the nucleus and in mitochondria. DNA in mitochondria, just like in the nucleus, must be faithfully copied and mistakes (i.e. mutations due to exogenous and endogenous DNA damaging agents) lead to formation of DNA lesions. Persistence of these DNA lesions leads to genomic instability and human diseases like cardiovascular, skeletal muscular and neurological disorders, cancer as well as normal aging process. Mitochondrial DNA (mtDNA) is anchored to the inner mitochondrial membrane thus is in a close proximity to the electron transport chain and is subjected to a constant attack by reactive oxygen species (ROS), generated as byproducts of oxidative phosphorylation (OXPHOS). As a result mitochondria must have a robust DNA repair mechanism which becomes particularly important in non-dividing cells. It is accepted that DNA base excision repair (BER) pathway is a major defense mechanism against oxidative damage in human mitochondria. Aptly localized on mitochondrial inner membrane, mitochondrial BER enzymes: catalytic subunit of DNA polymerase γ (PolγA) along with its accessory subunit, DNA polymerase γ (PolγB), inner-membrane 5'-exo/endonuclease (EXOG), Apurinic/apyrimidinic endonuclease 1 (APE1) and Ligase 3 (Lig3) form a membrane-bound, high molecular weight, complexes called “mitochondrial repairosome”, capable of carrying out complete DNA repair. Although BER can be readily detected in mitochondria and major components have been identified, the spatial-temporal organization of mitochondrial repairosome and molecular mechanism by which mtDNA is repaired is not well understood. The goal of this research project is to provide fundamental mechanistic insights into the assembly, composition, activities and structures of human mitochondrial repairosome.
Summary
In mammalian cells genetic information is stored in two compartments: in the nucleus and in the mitochondria. DNA in mitochondria (mtDNA), just like in theIn mammalian cells genetic information is stored in two locations: in the nucleus and in mitochondria. DNA in mitochondria, just like in the nucleus, must be faithfully copied and mistakes (i.e. mutations due to exogenous and endogenous DNA damaging agents) lead to formation of DNA lesions. Persistence of these DNA lesions leads to genomic instability and human diseases like cardiovascular, skeletal muscular and neurological disorders, cancer as well as normal aging process. Mitochondrial DNA (mtDNA) is anchored to the inner mitochondrial membrane thus is in a close proximity to the electron transport chain and is subjected to a constant attack by reactive oxygen species (ROS), generated as byproducts of oxidative phosphorylation (OXPHOS). As a result mitochondria must have a robust DNA repair mechanism which becomes particularly important in non-dividing cells. It is accepted that DNA base excision repair (BER) pathway is a major defense mechanism against oxidative damage in human mitochondria. Aptly localized on mitochondrial inner membrane, mitochondrial BER enzymes: catalytic subunit of DNA polymerase γ (PolγA) along with its accessory subunit, DNA polymerase γ (PolγB), inner-membrane 5'-exo/endonuclease (EXOG), Apurinic/apyrimidinic endonuclease 1 (APE1) and Ligase 3 (Lig3) form a membrane-bound, high molecular weight, complexes called “mitochondrial repairosome”, capable of carrying out complete DNA repair. Although BER can be readily detected in mitochondria and major components have been identified, the spatial-temporal organization of mitochondrial repairosome and molecular mechanism by which mtDNA is repaired is not well understood. The goal of this research project is to provide fundamental mechanistic insights into the assembly, composition, activities and structures of human mitochondrial repairosome.
Max ERC Funding
1 500 000 €
Duration
Start date: 2020-02-01, End date: 2025-01-31
Project acronym PROCONTRA
Project Smart-Contract Protocols: Theory for Applications
Researcher (PI) Stefan Michal DZIEMBOWSKI
Host Institution (HI) UNIWERSYTET WARSZAWSKI
Country Poland
Call Details Advanced Grant (AdG), PE6, ERC-2019-ADG
Summary Smart contracts are formal agreements that take the form of computer programs. They are typically written down, and automatically executed, on blockchains. Smart-contract protocols are algorithms that describe how these contracts operate in multiparty settings. Due to the large number of potential applications, interest in this field has exploded in the last few years. Also, the PI has generated important results through his work in this area. The ambitious goal of PROCONTRA is to transfigure this emerging field into a mature science. Our main research hypothesis is that smart-contract protocols will be used in real life and many of them will strongly rely on advanced cryptographic techniques and will need to be developed using modeling methods from theoretical cryptography.
We will work in this direction by proposing new solutions in this area, providing formal models and security proofs. Given the importance of these protocols, it is crucial to fully analyze their security before they are deployed in real life. Therefore, the first pillar of this project is to design a complete security model for analyzing them. The second pillar is to propose new smart-contract protocols and to extend the existing ones. Our protocols will be proven secure in the model we propose in the first pillar. This will be done using traditional “pen-and-paper” methods. However, the most important proofs will also be machine-checked using proof assistants. On a more theoretical side, we will also work on characterizing what tasks are in general achievable using smart contracts, and under what assumptions. Throughout the project, we will closely interact with the smart-contract practitioners, and with the industry, in order to understand what are the practically-relevant problems in this field and to ensure that the project’s outcome will have an impact beyond academia. This will also take a form of participation in the standardization efforts in this area.
Summary
Smart contracts are formal agreements that take the form of computer programs. They are typically written down, and automatically executed, on blockchains. Smart-contract protocols are algorithms that describe how these contracts operate in multiparty settings. Due to the large number of potential applications, interest in this field has exploded in the last few years. Also, the PI has generated important results through his work in this area. The ambitious goal of PROCONTRA is to transfigure this emerging field into a mature science. Our main research hypothesis is that smart-contract protocols will be used in real life and many of them will strongly rely on advanced cryptographic techniques and will need to be developed using modeling methods from theoretical cryptography.
We will work in this direction by proposing new solutions in this area, providing formal models and security proofs. Given the importance of these protocols, it is crucial to fully analyze their security before they are deployed in real life. Therefore, the first pillar of this project is to design a complete security model for analyzing them. The second pillar is to propose new smart-contract protocols and to extend the existing ones. Our protocols will be proven secure in the model we propose in the first pillar. This will be done using traditional “pen-and-paper” methods. However, the most important proofs will also be machine-checked using proof assistants. On a more theoretical side, we will also work on characterizing what tasks are in general achievable using smart contracts, and under what assumptions. Throughout the project, we will closely interact with the smart-contract practitioners, and with the industry, in order to understand what are the practically-relevant problems in this field and to ensure that the project’s outcome will have an impact beyond academia. This will also take a form of participation in the standardization efforts in this area.
Max ERC Funding
2 496 370 €
Duration
Start date: 2021-01-01, End date: 2025-12-31
