Project acronym AdriArchCult
Project Architectural Culture of the Early Modern Eastern Adriatic
Researcher (PI) Jasenka Gudelj
Host Institution (HI) UNIVERSITA CA' FOSCARI VENEZIA
Country Italy
Call Details Consolidator Grant (CoG), SH5, ERC-2019-COG
Summary During the 15th century, the political process of reducing the Eastern Adriatic, here considered as encompassing what is now littoral of Slovenia, Croatia and Montenegro, to a thin strip of border territories substantially separated from the continental massive to which they belong, reached its conclusion. The insularity of its large natural archipelago, i.e. almost exclusive dependence on the maritime communications, became characteristic even of mainland coastal towns, with lasting consequences. The project explores the impact of this change in the area between 15th and 18th c., focusing on architecture as the most evident materialization of a culture and its transformations. The goal is to examine the architectural culture in question in terms of both consumption and production. Factors such as political and economic consolidation of Venetian and Dubrovnik Republics as well as Habsburg Empire in the area, war and commerce with the Ottomans, but also the quick spread of revival of antiquity and the Catholic Revival, all fuelled the need for architectural creation with certain functional and symbolic characteristics, setting the cultural standards. On the other hand, the economics of production of architecture consisted of interrelated systems of the provision of materials (esp. Istrian stone) and organisation of construction sites, which, given the ease of the sea transport, resulted in an active market for architectural goods. This approach will provide an original contribution to the understanding of cultural practices that not only produced specific buildings, the most significant among which are now listed as World Heritage sites but also put into circulation ancient and modern models, techniques and materials for a European-wide audience. Moreover, it will investigate the trans-border and trans-confessional character of the architectural market, thus providing an innovative model for a study of such phenomena across Europe.
Summary
During the 15th century, the political process of reducing the Eastern Adriatic, here considered as encompassing what is now littoral of Slovenia, Croatia and Montenegro, to a thin strip of border territories substantially separated from the continental massive to which they belong, reached its conclusion. The insularity of its large natural archipelago, i.e. almost exclusive dependence on the maritime communications, became characteristic even of mainland coastal towns, with lasting consequences. The project explores the impact of this change in the area between 15th and 18th c., focusing on architecture as the most evident materialization of a culture and its transformations. The goal is to examine the architectural culture in question in terms of both consumption and production. Factors such as political and economic consolidation of Venetian and Dubrovnik Republics as well as Habsburg Empire in the area, war and commerce with the Ottomans, but also the quick spread of revival of antiquity and the Catholic Revival, all fuelled the need for architectural creation with certain functional and symbolic characteristics, setting the cultural standards. On the other hand, the economics of production of architecture consisted of interrelated systems of the provision of materials (esp. Istrian stone) and organisation of construction sites, which, given the ease of the sea transport, resulted in an active market for architectural goods. This approach will provide an original contribution to the understanding of cultural practices that not only produced specific buildings, the most significant among which are now listed as World Heritage sites but also put into circulation ancient and modern models, techniques and materials for a European-wide audience. Moreover, it will investigate the trans-border and trans-confessional character of the architectural market, thus providing an innovative model for a study of such phenomena across Europe.
Max ERC Funding
1 999 750 €
Duration
Start date: 2020-09-01, End date: 2025-08-31
Project acronym ADVODID
Project Advocacy in Digital Democracy: Use, Impact and Democratic Consequences
Researcher (PI) Anne RASMUSSEN
Host Institution (HI) KOBENHAVNS UNIVERSITET
Country Denmark
Call Details Consolidator Grant (CoG), SH2, ERC-2019-COG
Summary Digital technology has fundamentally changed the action repertoire of political campaigning and advocacy in the last decade. Despite its fundamental role in contemporary political strategy and potential to affect the quality of democracy, there is still little systematic evidence to assess and compare the real effects of online and offline advocacy tools. ADVODID will implement the first large-scale quantitative project designed to provide rich correlational and causal evidence on the effects of advocacy on citizens and policymakers, in both online and offline settings. It sets out to address - theoretically and empirically - the potentials and challenges for modern democracies that arise from digital advocacy tools. Its novelty lies in analyzing the use, impact and democratic consequences of digital advocacy strategies by assessing interactions of advocacy groups with both citizens and political representatives in a diverse set of eight countries (Australia, Chile, Denmark, India, the Netherlands, Spain, the UK, and the US). ADVODID will collect data on the advocacy agenda and strategy use of at least 400 carefully sampled advocates in these countries, and will assess agenda congruence with political and public agendas, and their dynamic development over time. Correlational analyses of different measures of advocacy success will be complemented by field experiments in cooperation with advocates in two countries, to supply causal evidence on how advocacy affects the positions and actions of policymakers and citizens. The project’s rich datasets will be used to assess and refine theories of democratic representation and the role of digital advocacy across different types of policy issues. ADVODID will greatly advance understanding of how modern advocacy impacts its target audiences and potentially changes participatory democracy. Its findings will have interdisciplinary and social relevance and inform ways to strengthen representative democracy in an online age.
Summary
Digital technology has fundamentally changed the action repertoire of political campaigning and advocacy in the last decade. Despite its fundamental role in contemporary political strategy and potential to affect the quality of democracy, there is still little systematic evidence to assess and compare the real effects of online and offline advocacy tools. ADVODID will implement the first large-scale quantitative project designed to provide rich correlational and causal evidence on the effects of advocacy on citizens and policymakers, in both online and offline settings. It sets out to address - theoretically and empirically - the potentials and challenges for modern democracies that arise from digital advocacy tools. Its novelty lies in analyzing the use, impact and democratic consequences of digital advocacy strategies by assessing interactions of advocacy groups with both citizens and political representatives in a diverse set of eight countries (Australia, Chile, Denmark, India, the Netherlands, Spain, the UK, and the US). ADVODID will collect data on the advocacy agenda and strategy use of at least 400 carefully sampled advocates in these countries, and will assess agenda congruence with political and public agendas, and their dynamic development over time. Correlational analyses of different measures of advocacy success will be complemented by field experiments in cooperation with advocates in two countries, to supply causal evidence on how advocacy affects the positions and actions of policymakers and citizens. The project’s rich datasets will be used to assess and refine theories of democratic representation and the role of digital advocacy across different types of policy issues. ADVODID will greatly advance understanding of how modern advocacy impacts its target audiences and potentially changes participatory democracy. Its findings will have interdisciplinary and social relevance and inform ways to strengthen representative democracy in an online age.
Max ERC Funding
1 986 922 €
Duration
Start date: 2021-08-01, End date: 2026-07-31
Project acronym AEONS
Project Advancing the Equation of state of Neutron Stars
Researcher (PI) Anna WATTS
Host Institution (HI) UNIVERSITEIT VAN AMSTERDAM
Country Netherlands
Call Details Consolidator Grant (CoG), PE9, ERC-2019-COG
Summary Densities in neutron star (NS) cores can reach up to ten times the density of a normal atomic nucleus, and the stabilising effect of gravitational confinement permits long-timescale weak interactions. This generates nucleonic matter that is extremely neutron-rich, and the exciting possibility of stable states of strange matter (hyperons or deconfined quarks). Our uncertainty about the nature of cold ultradense matter is encoded in the Equation of State (EOS), which can be mapped via the stellar structure equations to quantities like mass M and radius R that determine the exterior space-time.
One very promising technique for measuring the EOS exploits hotspots that form on the NS surface due to the pulsar mechanism, accretion streams, or during thermonuclear explosions in the stellar ocean. As the NS rotates, the hotspot gives rise to a pulsation and relativistic effects encode information about the EOS into the pulse profile. Pulse Profile Modelling (PPM), which employs relativistic ray-tracing and Bayesian inference codes to measure M-R and the EOS, is being pioneered by NASA’s NICER telescope, which is poised to deliver its first results in 2019.
Complexities, that have only become apparent with exposure to real data, mean that there is work to be done if we are to have confidence in the nominal 5-10% accuracy of NICER’s M-R results. AEONS will deliver this. The project will also look ahead to the next generation of large-area X-ray timing telescopes, since it is only then that PPM will place tight constraints on dense matter models. The sources these missions target, accreting neutron stars, pose challenges for PPM such as variability, surface pattern uncertainty, and polarimetric signatures. AEONS will develop a robust pipeline for accreting NS PPM and embed it in a multi-messenger EOS inference framework with radio and gravitational wave constraints. This will ensure that PPM delivers major advances in our understanding of the nature of matter.
Summary
Densities in neutron star (NS) cores can reach up to ten times the density of a normal atomic nucleus, and the stabilising effect of gravitational confinement permits long-timescale weak interactions. This generates nucleonic matter that is extremely neutron-rich, and the exciting possibility of stable states of strange matter (hyperons or deconfined quarks). Our uncertainty about the nature of cold ultradense matter is encoded in the Equation of State (EOS), which can be mapped via the stellar structure equations to quantities like mass M and radius R that determine the exterior space-time.
One very promising technique for measuring the EOS exploits hotspots that form on the NS surface due to the pulsar mechanism, accretion streams, or during thermonuclear explosions in the stellar ocean. As the NS rotates, the hotspot gives rise to a pulsation and relativistic effects encode information about the EOS into the pulse profile. Pulse Profile Modelling (PPM), which employs relativistic ray-tracing and Bayesian inference codes to measure M-R and the EOS, is being pioneered by NASA’s NICER telescope, which is poised to deliver its first results in 2019.
Complexities, that have only become apparent with exposure to real data, mean that there is work to be done if we are to have confidence in the nominal 5-10% accuracy of NICER’s M-R results. AEONS will deliver this. The project will also look ahead to the next generation of large-area X-ray timing telescopes, since it is only then that PPM will place tight constraints on dense matter models. The sources these missions target, accreting neutron stars, pose challenges for PPM such as variability, surface pattern uncertainty, and polarimetric signatures. AEONS will develop a robust pipeline for accreting NS PPM and embed it in a multi-messenger EOS inference framework with radio and gravitational wave constraints. This will ensure that PPM delivers major advances in our understanding of the nature of matter.
Max ERC Funding
2 425 000 €
Duration
Start date: 2020-06-01, End date: 2025-05-31
Project acronym AFRAB
Project African Abolitionism: The Rise and Transformations of Anti-Slavery in Africa
Researcher (PI) Benedetta ROSSI
Host Institution (HI) UNIVERSITY COLLEGE LONDON
Country United Kingdom
Call Details Advanced Grant (AdG), SH6, ERC-2019-ADG
Summary The historiography of Euro-American abolitionism is so vast that it has a history of its own (Brown 2006). By contrast, research on African abolitionism is a narrow field focused primarily on European anti-slavery activities. It presupposes that when Europe abolished slavery in Africa, Africans became abolitionists. This conclusion is unfounded. Many general questions have never been asked: When and where did African abolitionist movements develop? Who are the main ideologues of African abolitionism? How did abolitionism spread, among which groups? What forms of political struggle did African anti-slavery give rise to? While individual African abolitionists and regional movements have attracted limited attention, there is no major review of the phenomenon on a continental scale. AFRAB fills this gap. It contributes to African and global history and slavery studies by analyzing and comparing African abolitionist ideas and anti-slavery movements, the long-term consequences of European abolitionism, and the resilience of pro-slavery discourses.
Summary
The historiography of Euro-American abolitionism is so vast that it has a history of its own (Brown 2006). By contrast, research on African abolitionism is a narrow field focused primarily on European anti-slavery activities. It presupposes that when Europe abolished slavery in Africa, Africans became abolitionists. This conclusion is unfounded. Many general questions have never been asked: When and where did African abolitionist movements develop? Who are the main ideologues of African abolitionism? How did abolitionism spread, among which groups? What forms of political struggle did African anti-slavery give rise to? While individual African abolitionists and regional movements have attracted limited attention, there is no major review of the phenomenon on a continental scale. AFRAB fills this gap. It contributes to African and global history and slavery studies by analyzing and comparing African abolitionist ideas and anti-slavery movements, the long-term consequences of European abolitionism, and the resilience of pro-slavery discourses.
Max ERC Funding
2 499 951 €
Duration
Start date: 2020-10-01, End date: 2025-09-30
Project acronym AGEMEC
Project Age-dependent mechanisms of sporadic Alzheimer’s Disease in patient-derived neurons
Researcher (PI) Jerome Stefan MERTENS
Host Institution (HI) UNIVERSITAET INNSBRUCK
Country Austria
Call Details Starting Grant (StG), LS5, ERC-2019-STG
Summary Sporadic Alzheimer’s Disease (AD) accounts for the overwhelming majority of all AD cases and exclusively affects people at old age. However, mechanistic links between aging and AD pathology remain elusive. We recently discovered that in contrast to iPSC models, direct conversion of human fibroblasts into induced neurons (iNs) preserves signatures of aging, and we have started to develop a patient-based iN model system for AD. Our preliminary data suggests that AD iNs show a neuronal but de-differentiated transcriptome signature. In this project, we first combine cellular neuroscience assays and epigenetic landscape profiling to understand how neurons in AD fail to maintain their fully mature differentiated state, which might be key in permitting disease development. Next, using metabolome analysis including mass spec metabolite assessment, we explore a profound metabolic switch in AD iNs that shows surprisingly many aspects of aerobic glycolysis observed also in cancer. While this link might represent an interesting connection between two age-dependent and de-differentiation-associated diseases, it also opens new avenues to harness knowledge from the cancer field to better understand sporadic AD. We further focus on identifying and manipulating key metabolic regulators that appear to malfunction in an age-dependent manner, with the ultimate goal to define potential targets and treatment strategies. Finally, we will focus on early AD mechanisms by extending our model to mild cognitive impairment (MCI) patients. An agnostic transcriptome and epigenetic landscape approach of glutamatergic and serotonergic iNs will help to determine the earliest and probably most treatable disease mechanisms of AD, and to better understand the contribution of neuropsychiatric risk factors. We anticipate that this project will help to illuminate the mechanistic interface of cellular aging and the development of AD, and help to define new strategies for AD.
Summary
Sporadic Alzheimer’s Disease (AD) accounts for the overwhelming majority of all AD cases and exclusively affects people at old age. However, mechanistic links between aging and AD pathology remain elusive. We recently discovered that in contrast to iPSC models, direct conversion of human fibroblasts into induced neurons (iNs) preserves signatures of aging, and we have started to develop a patient-based iN model system for AD. Our preliminary data suggests that AD iNs show a neuronal but de-differentiated transcriptome signature. In this project, we first combine cellular neuroscience assays and epigenetic landscape profiling to understand how neurons in AD fail to maintain their fully mature differentiated state, which might be key in permitting disease development. Next, using metabolome analysis including mass spec metabolite assessment, we explore a profound metabolic switch in AD iNs that shows surprisingly many aspects of aerobic glycolysis observed also in cancer. While this link might represent an interesting connection between two age-dependent and de-differentiation-associated diseases, it also opens new avenues to harness knowledge from the cancer field to better understand sporadic AD. We further focus on identifying and manipulating key metabolic regulators that appear to malfunction in an age-dependent manner, with the ultimate goal to define potential targets and treatment strategies. Finally, we will focus on early AD mechanisms by extending our model to mild cognitive impairment (MCI) patients. An agnostic transcriptome and epigenetic landscape approach of glutamatergic and serotonergic iNs will help to determine the earliest and probably most treatable disease mechanisms of AD, and to better understand the contribution of neuropsychiatric risk factors. We anticipate that this project will help to illuminate the mechanistic interface of cellular aging and the development of AD, and help to define new strategies for AD.
Max ERC Funding
1 499 565 €
Duration
Start date: 2020-02-01, End date: 2025-01-31
Project acronym AGILEFLIGHT
Project Low-latency Perception and Action for Agile Vision-based Flight
Researcher (PI) Davide SCARAMUZZA
Host Institution (HI) UNIVERSITAT ZURICH
Country Switzerland
Call Details Consolidator Grant (CoG), PE7, ERC-2019-COG
Summary Drones are disrupting industries, such as agriculture, package delivery, inspection, and search and rescue. However, they are still either controlled by a human pilot or heavily rely on GPS for navigating autonomously. The alternative to GPS are onboard sensors, such as cameras: from the raw data, a local 3D map of the environment is built, which is then used to plan a safe trajectory to the goal. While the underlying algorithms are well understood, we are still far from having autonomous drones that can navigate through complex environments as good as human pilots. State-of-the-art perception and control algorithms are mature but not robust: coping with unreliable state estimation, low-latency perception, real-time planning in dynamic environments, and tight coupling of perception and action under severe resource constraints are all still unsolved research problems. Another issue is that, because battery energy density is increasing at a very slow rate, drones need to navigate faster in order to accomplish more within their limited flight time. To obtain more agile robots, we need faster sensors and low-latency processing.
The goal of this project is to develop novel scientific methods that would allow me to demonstrate autonomous, vision-based, agile quadrotor navigation in unknown, GPS-denied, and cluttered environments with possibly moving obstacles, which can be as effective in terms of maneuverability and agility as those of professional drone pilots. The outcome would not only be beneficial for disaster response scenarios, but also for other scenarios, such as aerial delivery or inspection. To achieve this ambitious goal, I will first develop robust, low-latency, multimodal perception algorithms that combine the advantages of standard cameras with event cameras. Then, I will develop novel methods that unify perception and state estimation together with planning and control to enable agile maneuvers through cluttered, unknown, and dynamic environments.
Summary
Drones are disrupting industries, such as agriculture, package delivery, inspection, and search and rescue. However, they are still either controlled by a human pilot or heavily rely on GPS for navigating autonomously. The alternative to GPS are onboard sensors, such as cameras: from the raw data, a local 3D map of the environment is built, which is then used to plan a safe trajectory to the goal. While the underlying algorithms are well understood, we are still far from having autonomous drones that can navigate through complex environments as good as human pilots. State-of-the-art perception and control algorithms are mature but not robust: coping with unreliable state estimation, low-latency perception, real-time planning in dynamic environments, and tight coupling of perception and action under severe resource constraints are all still unsolved research problems. Another issue is that, because battery energy density is increasing at a very slow rate, drones need to navigate faster in order to accomplish more within their limited flight time. To obtain more agile robots, we need faster sensors and low-latency processing.
The goal of this project is to develop novel scientific methods that would allow me to demonstrate autonomous, vision-based, agile quadrotor navigation in unknown, GPS-denied, and cluttered environments with possibly moving obstacles, which can be as effective in terms of maneuverability and agility as those of professional drone pilots. The outcome would not only be beneficial for disaster response scenarios, but also for other scenarios, such as aerial delivery or inspection. To achieve this ambitious goal, I will first develop robust, low-latency, multimodal perception algorithms that combine the advantages of standard cameras with event cameras. Then, I will develop novel methods that unify perception and state estimation together with planning and control to enable agile maneuvers through cluttered, unknown, and dynamic environments.
Max ERC Funding
2 000 000 €
Duration
Start date: 2020-09-01, End date: 2025-08-31
Project acronym AgingTimer
Project Systems biology of the individual stochastic timer of aging
Researcher (PI) Uri ALON, Tali Kimchi, Valery Krizhanovsky
Host Institution (HI) WEIZMANN INSTITUTE OF SCIENCE
Country Israel
Call Details Synergy Grants (SyG), SyG, ERC-2019-SyG
Summary Aging is the biggest risk factor for frailty and death. However, we lack basic understanding of a fundamental question: Why do genetically identical organisms raised in the same conditions get sick and die at different times? If we understood the stochastic timer that drives aging in each individual, we could devise ways to turn back the timer and treat age-related diseases, extending the healthy lifespan. This requires addressing both molecular and social factors that vary between individuals, such as socioeconomic status in humans and social ranking in mice, which impact every aspect of aging. This synergy program aims to identify the stochastic timer of aging and develop methods to read the timer and turn it back. We use mice as a tractable organism relevant to human aging, and combine three disciplines: 1) systems biology to mathematically define the stochastic timer of aging and the basic concepts needed to understand its production, removal and noise processes; 2) neurobiology of behavioral individuality; and 3) biology of cellular senescence, which studies the most promising candidate for the timer: senescent cells that accumulate with age, causing chronic inflammation and whose removal delays age-related decline. To pinpoint the timer, we will follow the natural variability of large cohorts of genetically identical mice, tracked across the lifespan by video and RFID tags. We will measure a battery of behavioral, physiological and molecular parameters, as well as senescent cells in multiple organs throughout life. We will use new mouse models that allow us to visualize, pull down and ablate senescent cells, to provide full molecular profiles of senescent cells in different organs and to characterize their immune-surveillance mechanisms. This study will provide basic understanding of the timer of aging and provide ways to read the timer. Moreover, we will offer new ways to set back the timer in order to address age-related diseases and functional decline.
Summary
Aging is the biggest risk factor for frailty and death. However, we lack basic understanding of a fundamental question: Why do genetically identical organisms raised in the same conditions get sick and die at different times? If we understood the stochastic timer that drives aging in each individual, we could devise ways to turn back the timer and treat age-related diseases, extending the healthy lifespan. This requires addressing both molecular and social factors that vary between individuals, such as socioeconomic status in humans and social ranking in mice, which impact every aspect of aging. This synergy program aims to identify the stochastic timer of aging and develop methods to read the timer and turn it back. We use mice as a tractable organism relevant to human aging, and combine three disciplines: 1) systems biology to mathematically define the stochastic timer of aging and the basic concepts needed to understand its production, removal and noise processes; 2) neurobiology of behavioral individuality; and 3) biology of cellular senescence, which studies the most promising candidate for the timer: senescent cells that accumulate with age, causing chronic inflammation and whose removal delays age-related decline. To pinpoint the timer, we will follow the natural variability of large cohorts of genetically identical mice, tracked across the lifespan by video and RFID tags. We will measure a battery of behavioral, physiological and molecular parameters, as well as senescent cells in multiple organs throughout life. We will use new mouse models that allow us to visualize, pull down and ablate senescent cells, to provide full molecular profiles of senescent cells in different organs and to characterize their immune-surveillance mechanisms. This study will provide basic understanding of the timer of aging and provide ways to read the timer. Moreover, we will offer new ways to set back the timer in order to address age-related diseases and functional decline.
Max ERC Funding
8 687 500 €
Duration
Start date: 2020-02-01, End date: 2026-01-31
Project acronym AGRICON
Project Ancient genomic reconstruction of convergent evolution to agriculture
Researcher (PI) Pontus Rickard Otto Peter Skoglund
Host Institution (HI) THE FRANCIS CRICK INSTITUTE LIMITED
Country United Kingdom
Call Details Starting Grant (StG), LS8, ERC-2019-STG
Summary As global climates warmed ca. 10,000 years ago came a remarkable convergent transformation of human lifestyles that occurred independently in multiple continents and human populations. This transition from hunter-gatherer subsistence to food-production catalysed large-scale population growth, offering the opportunity for increased rates of adaptation, but also rapidly presented a large number of independent human populations with a new evolutionary challenge. This project will use ancient population genomics—the only way to directly reconstruct human genetic evolution—to study whether evolutionary processes during the agricultural transition differed in differed regions. Which genomic adaptations were associated with the agricultural transition? Did adaptation to hunter-gatherer and agricultural lifestyles act on similar genetic architecture in different instances? To which extent did adaptation in domestic dogs—the only species domesticated prior to the agricultural transition—occur in convergence with humans? To answer these questions, the project will generate ancient genomic data from pre-agricultural and early agricultural populations from multiple human- and domestic dog populations from Africa, Central America, and Southeast Asia. This will be achieved with direct sequencing as well as a new human ~850,000 SNP capture panel designed to avoid bias towards Eurasian ancestry. We will also develop new computational methods robust to the challenges posed by ancient genomes to identify adaptive admixture, analyse copy number variation, test continuous population models, and statistically assess convergence in the genomic architecture of adaptation. Leveraging cutting-edge ancient genomics and two model organisms for the genomic basis of phenotypic variation, this project aims to reconstruct the universal evolutionary phenomena underpinning a watershed evolutionary episode that shapes global biodiversity and the human condition to this day.
Summary
As global climates warmed ca. 10,000 years ago came a remarkable convergent transformation of human lifestyles that occurred independently in multiple continents and human populations. This transition from hunter-gatherer subsistence to food-production catalysed large-scale population growth, offering the opportunity for increased rates of adaptation, but also rapidly presented a large number of independent human populations with a new evolutionary challenge. This project will use ancient population genomics—the only way to directly reconstruct human genetic evolution—to study whether evolutionary processes during the agricultural transition differed in differed regions. Which genomic adaptations were associated with the agricultural transition? Did adaptation to hunter-gatherer and agricultural lifestyles act on similar genetic architecture in different instances? To which extent did adaptation in domestic dogs—the only species domesticated prior to the agricultural transition—occur in convergence with humans? To answer these questions, the project will generate ancient genomic data from pre-agricultural and early agricultural populations from multiple human- and domestic dog populations from Africa, Central America, and Southeast Asia. This will be achieved with direct sequencing as well as a new human ~850,000 SNP capture panel designed to avoid bias towards Eurasian ancestry. We will also develop new computational methods robust to the challenges posed by ancient genomes to identify adaptive admixture, analyse copy number variation, test continuous population models, and statistically assess convergence in the genomic architecture of adaptation. Leveraging cutting-edge ancient genomics and two model organisms for the genomic basis of phenotypic variation, this project aims to reconstruct the universal evolutionary phenomena underpinning a watershed evolutionary episode that shapes global biodiversity and the human condition to this day.
Max ERC Funding
1 500 000 €
Duration
Start date: 2019-11-01, End date: 2024-10-31
Project acronym AGRIMKT
Project Improving Market Access for Farmers: Evidence from East Africa
Researcher (PI) Lorenzo Casaburi
Host Institution (HI) UNIVERSITAT ZURICH
Country Switzerland
Call Details Starting Grant (StG), SH1, ERC-2019-STG
Summary Agriculture employs the majority of the labor force in many developing countries, particularly in Sub-Saharan Africa. Increasing efficiency of agricultural production is a crucial step to foster economic development. Limited access to both input and output markets is widely considered a major obstacle to technology adoption and, in turn, to agricultural productivity.
In this proposal, I outline a research program that focuses on improving farmers’ market access in East Africa. The research builds on the expertise I have developed on these topics over the last ten years.
The research program consists of three related projects. In Project A, we will use a randomized experiment to evaluate the impact of a holistic approach to improve market access: contract farming. The prevalence of contract farming arrangements in the developing world is growing. However, so far, there is no experimental evidence on their impact. We have established a partnership with a large contract farming company in Kenya, which has agreed to randomize the order in which it will expand to new villages.
In Project B, we will study how to increase demand for crop insurance among smallholders. Building on previous successful experimental work, we will test i) whether offering pay-at-harvest insurance, as opposed to upfront premium pay, raises take-up, ii) which behavioral mechanisms may drive such response, and iii) whether pay-at-harvest can foster sustained insurance demand over multiple crop seasons.
In Project C, we will combine parcel-level proprietary data for three decades that we obtained from a large agribusiness company with land registry data to study the determinants and impact of land market access for smallholders.
The research program will generate new insights on how to improve access to key markets for agricultural producers. We expect the findings of the study will generate high interest among academics, development practitioners, and policymakers.
Summary
Agriculture employs the majority of the labor force in many developing countries, particularly in Sub-Saharan Africa. Increasing efficiency of agricultural production is a crucial step to foster economic development. Limited access to both input and output markets is widely considered a major obstacle to technology adoption and, in turn, to agricultural productivity.
In this proposal, I outline a research program that focuses on improving farmers’ market access in East Africa. The research builds on the expertise I have developed on these topics over the last ten years.
The research program consists of three related projects. In Project A, we will use a randomized experiment to evaluate the impact of a holistic approach to improve market access: contract farming. The prevalence of contract farming arrangements in the developing world is growing. However, so far, there is no experimental evidence on their impact. We have established a partnership with a large contract farming company in Kenya, which has agreed to randomize the order in which it will expand to new villages.
In Project B, we will study how to increase demand for crop insurance among smallholders. Building on previous successful experimental work, we will test i) whether offering pay-at-harvest insurance, as opposed to upfront premium pay, raises take-up, ii) which behavioral mechanisms may drive such response, and iii) whether pay-at-harvest can foster sustained insurance demand over multiple crop seasons.
In Project C, we will combine parcel-level proprietary data for three decades that we obtained from a large agribusiness company with land registry data to study the determinants and impact of land market access for smallholders.
The research program will generate new insights on how to improve access to key markets for agricultural producers. We expect the findings of the study will generate high interest among academics, development practitioners, and policymakers.
Max ERC Funding
1 499 913 €
Duration
Start date: 2021-01-01, End date: 2025-12-31
Project acronym AimingT6SS
Project Mechanisms of dynamic localization of the bacterial Type 6 secretion system assembly
Researcher (PI) Marek BASLER
Host Institution (HI) UNIVERSITAT BASEL
Country Switzerland
Call Details Consolidator Grant (CoG), LS6, ERC-2019-COG
Summary The Type 6 secretion system (T6SS) allows Gram-negative bacteria to deliver toxins into both eukaryotic and bacterial target cells and thus cause disease or kill competitors. T6SS is composed of four main parts: a membrane complex, a baseplate and a long spring-like sheath wrapped around an inner tube. Sheath contraction generates a large amount of energy to push the tube with associated toxins through the baseplate and membrane complex out of the cell. However, the reach of the T6SS tube is limited and thus a direct contact with the target membrane and precise positioning of T6SS assembly is required for protein translocation. In this proposal, we will unravel principles of spatial and temporal coordination of T6SS assembly that we have recently observed in several bacterial species. We will study how cells sense attacks from neighboring bacteria to dynamically localize its T6SS. We will describe how bacteria initiate and position T6SS assembly in response to physical cell-cell interactions. We will identify the principles and the role of T6SS localization in intracellular pathogens. Using genetic and biochemical approaches, we will identify and characterize proteins interacting with the core components of T6SS and test their role in initiation and positioning of T6SS assembly. We will search for peptidoglycan remodeling enzymes required for T6SS assembly. We will use advanced microscopy techniques to describe dynamic localization of proteins upon T6SS activation to establish the order of their assembly. We will quantify how much T6SS aiming increases efficiency of protein delivery and T6SS function during bacterial competition and pathogenesis. Overall, we will unravel novel principles of spatial and temporal control of localization of protein complexes and show how this allows bacteria to quickly respond to external cues and interact with their environment.
Summary
The Type 6 secretion system (T6SS) allows Gram-negative bacteria to deliver toxins into both eukaryotic and bacterial target cells and thus cause disease or kill competitors. T6SS is composed of four main parts: a membrane complex, a baseplate and a long spring-like sheath wrapped around an inner tube. Sheath contraction generates a large amount of energy to push the tube with associated toxins through the baseplate and membrane complex out of the cell. However, the reach of the T6SS tube is limited and thus a direct contact with the target membrane and precise positioning of T6SS assembly is required for protein translocation. In this proposal, we will unravel principles of spatial and temporal coordination of T6SS assembly that we have recently observed in several bacterial species. We will study how cells sense attacks from neighboring bacteria to dynamically localize its T6SS. We will describe how bacteria initiate and position T6SS assembly in response to physical cell-cell interactions. We will identify the principles and the role of T6SS localization in intracellular pathogens. Using genetic and biochemical approaches, we will identify and characterize proteins interacting with the core components of T6SS and test their role in initiation and positioning of T6SS assembly. We will search for peptidoglycan remodeling enzymes required for T6SS assembly. We will use advanced microscopy techniques to describe dynamic localization of proteins upon T6SS activation to establish the order of their assembly. We will quantify how much T6SS aiming increases efficiency of protein delivery and T6SS function during bacterial competition and pathogenesis. Overall, we will unravel novel principles of spatial and temporal control of localization of protein complexes and show how this allows bacteria to quickly respond to external cues and interact with their environment.
Max ERC Funding
2 493 650 €
Duration
Start date: 2021-01-01, End date: 2025-12-31