Project acronym BETWEEN THE TIMES
Project “Between the Times”: Embattled Temporalities and Political Imagination in Interwar Europe
Researcher (PI) Liisi KEEDUS
Host Institution (HI) TALLINN UNIVERSITY
Country Estonia
Call Details Starting Grant (StG), SH6, ERC-2017-STG
Summary The proposed project offers a new, pan-European intellectual history of the political imagination in the interwar period that places the demise of historicism and progressivism – and the emerging anti-teleological visions of time – at the center of some of its most innovative ethical, political and methodological pursuits. It argues that only a distinctively cross-disciplinary and European narrative can capture the full ramifications and legacies of a fundamental rupture in thought conventionally, yet inadequately confined to the German cultural space and termed “anti-historicism”. It innovates narratively by exploring politically and theoretically interlaced reinventions of temporality across and between different disciplines (theology, jurisprudence, classical studies, literary theory, linguistics, sociology, philosophy), as well as other creative fields. It experiments methodologically by reconstructing the dynamics of political thought prosopographically, through intellectual groupings at the forefront of the scholarly and political debates of the period. It challenges the sufficiency of the standard focus in interwar intellectual history on one or two, at most three (usually “Western” European) national contexts by following out the interactions of these groupings in France, Britain, Germany, Russia, Czechoslovakia, and Romania – groupings whose members frequently moved across national contexts. What were the political languages encoded in the reinventions of time, and vice versa – how were political aims translated into and advanced through theoretical innovation? How did these differ in different national contexts, and why? What are the fragmented legacies of this rupture, disbursed in and through the philosophical, methodological and political dicta and dogmas that rooted themselves in post-1945 thought? This project provides the first comprehensive answer to these fundamental questions about the intellectual identity of Europe and its historicities.
Summary
The proposed project offers a new, pan-European intellectual history of the political imagination in the interwar period that places the demise of historicism and progressivism – and the emerging anti-teleological visions of time – at the center of some of its most innovative ethical, political and methodological pursuits. It argues that only a distinctively cross-disciplinary and European narrative can capture the full ramifications and legacies of a fundamental rupture in thought conventionally, yet inadequately confined to the German cultural space and termed “anti-historicism”. It innovates narratively by exploring politically and theoretically interlaced reinventions of temporality across and between different disciplines (theology, jurisprudence, classical studies, literary theory, linguistics, sociology, philosophy), as well as other creative fields. It experiments methodologically by reconstructing the dynamics of political thought prosopographically, through intellectual groupings at the forefront of the scholarly and political debates of the period. It challenges the sufficiency of the standard focus in interwar intellectual history on one or two, at most three (usually “Western” European) national contexts by following out the interactions of these groupings in France, Britain, Germany, Russia, Czechoslovakia, and Romania – groupings whose members frequently moved across national contexts. What were the political languages encoded in the reinventions of time, and vice versa – how were political aims translated into and advanced through theoretical innovation? How did these differ in different national contexts, and why? What are the fragmented legacies of this rupture, disbursed in and through the philosophical, methodological and political dicta and dogmas that rooted themselves in post-1945 thought? This project provides the first comprehensive answer to these fundamental questions about the intellectual identity of Europe and its historicities.
Max ERC Funding
1 425 000 €
Duration
Start date: 2018-06-01, End date: 2023-05-31
Project acronym CerQuS
Project Certified Quantum Security
Researcher (PI) Dominique Peer Ghislain UNRUH
Host Institution (HI) TARTU ULIKOOL
Country Estonia
Call Details Consolidator Grant (CoG), PE6, ERC-2018-COG
Summary "Digital communication permeates all areas of today's daily life. Cryptographic protocols are used to secure that
communication. Quantum communication and the advent of quantum computers both threaten existing cryptographic
solutions, and create new opportunities for secure protocols. The security of cryptographic systems is normally ensured by
mathematical proofs. Due to human error, however, these proofs often contain errors, limiting the usefulness of said proofs.
This is especially true in the case of quantum protocols since human intuition is well-adapted to the classical world, but not
to quantum mechanics. To resolve this problem, methods for verifying cryptographic security proofs using computers (i.e.,
for ""certifying"" the security) have been developed. Yet, all existing verification approaches handle classical cryptography
only - for quantum protocols, no approaches exist.
This project will lay the foundations for the verification of quantum cryptography. We will design logics and software tools
for developing and verifying security proofs on the computer, both for classical protocols secure against quantum computer
(post-quantum security) and for protocols that use quantum communication.
Our main approach is the design of a logic (quantum relational Hoare logic, qRHL) for reasoning about the relationship
between pairs of quantum programs, together with an ecosystem of manual and automated reasoning tools, culminating in
fully certified security proofs for real-world quantum protocols.
As a final result, the project will improve the security of protocols in the quantum age, by removing one possible source of
human error. In addition, the project directly impacts the research community, by providing new foundations in program
verification, and by providing cryptographers with new tools for the verification of their protocols.
"
Summary
"Digital communication permeates all areas of today's daily life. Cryptographic protocols are used to secure that
communication. Quantum communication and the advent of quantum computers both threaten existing cryptographic
solutions, and create new opportunities for secure protocols. The security of cryptographic systems is normally ensured by
mathematical proofs. Due to human error, however, these proofs often contain errors, limiting the usefulness of said proofs.
This is especially true in the case of quantum protocols since human intuition is well-adapted to the classical world, but not
to quantum mechanics. To resolve this problem, methods for verifying cryptographic security proofs using computers (i.e.,
for ""certifying"" the security) have been developed. Yet, all existing verification approaches handle classical cryptography
only - for quantum protocols, no approaches exist.
This project will lay the foundations for the verification of quantum cryptography. We will design logics and software tools
for developing and verifying security proofs on the computer, both for classical protocols secure against quantum computer
(post-quantum security) and for protocols that use quantum communication.
Our main approach is the design of a logic (quantum relational Hoare logic, qRHL) for reasoning about the relationship
between pairs of quantum programs, together with an ecosystem of manual and automated reasoning tools, culminating in
fully certified security proofs for real-world quantum protocols.
As a final result, the project will improve the security of protocols in the quantum age, by removing one possible source of
human error. In addition, the project directly impacts the research community, by providing new foundations in program
verification, and by providing cryptographers with new tools for the verification of their protocols.
"
Max ERC Funding
1 716 475 €
Duration
Start date: 2019-06-01, End date: 2024-05-31
Project acronym COSMOLOCALISM
Project Design Global, Manufacture Local: Assessing the Practices, Innovation, and Sustainability Potential of an Emerging Mode of Production
Researcher (PI) Vasileios KOSTAKIS
Host Institution (HI) TALLINNA TEHNIKAÜLIKOOL
Country Estonia
Call Details Starting Grant (StG), SH2, ERC-2018-STG
Summary COSMOLOCALISM will document, analyse, test, evaluate, and create awareness about an emerging mode of production, based on the confluence of the digital commons (e.g. open knowledge and design) with local manufacturing and automation technologies (from 3D printing and CNC machines to low-tech tools and crafts). This convergence could catalyse the transition to new inclusive and circular productive models, such as the “design global, manufacture local” (DGML) model.
DGML describes the processes through which design is developed as a global digital commons, whereas the manufacturing takes place locally, through shared infrastructures and with local biophysical conditions in mind. DGML seems to form economies of scope that promote sustainability and open innovation while celebrating new ways of cooperation. However, such claims rest on thin conceptual and empirical foundations.
COSMOLOCALISM is a multiphase, pilot-driven investigation of the DGML phenomenon that seeks to understand relevant organisational models, their evolution, and their broader political economy/ecology and policy implications. Through the lens of diverse case studies and participatory action research, the conditions under which the DGML model thrives will be explored.
COSMOLOCALISM has three concurrent streams: practices; innovation; and sustainability. First, DGML practices will be studied, patterns will be recognised and their form, function, cultural values, and governance structure will be determined. Second, the relevant open innovation ecosystems and their potential to reorient design and manufacturing practices will be examined. Third, selected DGML products will be evaluated from an environmental sustainability perspective, involving both qualitative and quantitative methods. The interdisciplinary nature of COSMOLOCALISM will explore new horizons to substantively improve our understanding of how we could do “more” and “better” with less.
Summary
COSMOLOCALISM will document, analyse, test, evaluate, and create awareness about an emerging mode of production, based on the confluence of the digital commons (e.g. open knowledge and design) with local manufacturing and automation technologies (from 3D printing and CNC machines to low-tech tools and crafts). This convergence could catalyse the transition to new inclusive and circular productive models, such as the “design global, manufacture local” (DGML) model.
DGML describes the processes through which design is developed as a global digital commons, whereas the manufacturing takes place locally, through shared infrastructures and with local biophysical conditions in mind. DGML seems to form economies of scope that promote sustainability and open innovation while celebrating new ways of cooperation. However, such claims rest on thin conceptual and empirical foundations.
COSMOLOCALISM is a multiphase, pilot-driven investigation of the DGML phenomenon that seeks to understand relevant organisational models, their evolution, and their broader political economy/ecology and policy implications. Through the lens of diverse case studies and participatory action research, the conditions under which the DGML model thrives will be explored.
COSMOLOCALISM has three concurrent streams: practices; innovation; and sustainability. First, DGML practices will be studied, patterns will be recognised and their form, function, cultural values, and governance structure will be determined. Second, the relevant open innovation ecosystems and their potential to reorient design and manufacturing practices will be examined. Third, selected DGML products will be evaluated from an environmental sustainability perspective, involving both qualitative and quantitative methods. The interdisciplinary nature of COSMOLOCALISM will explore new horizons to substantively improve our understanding of how we could do “more” and “better” with less.
Max ERC Funding
1 017 275 €
Duration
Start date: 2019-01-01, End date: 2022-12-31
Project acronym DEEP PURPLE
Project DEEP PURPLE: darkening of the Greenland Ice Sheet
Researcher (PI) Martyn TRANTER, Alexandre Barbosa Anesio, Liane Benning
Host Institution (HI) AARHUS UNIVERSITET
Country Denmark
Call Details Synergy Grants (SyG), SyG, ERC-2019-SyG
Summary The stability of the Greenland Ice Sheet (GrIS) is a threat to coastal communities worldwide. The PIs have changed our understanding of why it darkens during the melt season, becoming increasingly deep purple due to pigmented ice algal blooms in the ice surface, producing more melt and accelerating the GrIS towards its tipping point, and increasing sea level. The next step jump in our understanding of biological darkening will be provided by DEEP PURPLE, which will establish the factors that control ice algal blooms. These factors are essential for modelling of future melting, which require a process-based understanding of blooming. DEEP PURPLE will quantify the synergies between the biology, chemistry and physics of ice algae micro-niches in rotting, melting ice, and examine the combination of factors which stabilise them. State-of-the-science analytical and observational methods will be employed to characterise the complex mosaic of wet ice habitats, dependent on factors such as the hydrology, nutrient status, particulate content and light fields within these continually evolving ice-water-particulate-microbe systems. We will quantitatively assess why and how the fine light mineral dust particulates contained within the melting ice amplify the growth of ice algae. The particulate content and composition of different layers in the GrIS is dependent on age, and so the algae that the melting ice can support may fundamentally change over time. We look back to understand if the ice biome has changed through the Anthropocene via analyse of fjord sediments. The first draft genome of ice algae will show their key adaptations to glacier surface habitats. DEEP PURPLE looks forward by providing the critical field data sets and conceptual models of ice algal growth that will facilitate the next generation of predictive models of sea level rise due to biologically enhanced melting of the GrIS.
Summary
The stability of the Greenland Ice Sheet (GrIS) is a threat to coastal communities worldwide. The PIs have changed our understanding of why it darkens during the melt season, becoming increasingly deep purple due to pigmented ice algal blooms in the ice surface, producing more melt and accelerating the GrIS towards its tipping point, and increasing sea level. The next step jump in our understanding of biological darkening will be provided by DEEP PURPLE, which will establish the factors that control ice algal blooms. These factors are essential for modelling of future melting, which require a process-based understanding of blooming. DEEP PURPLE will quantify the synergies between the biology, chemistry and physics of ice algae micro-niches in rotting, melting ice, and examine the combination of factors which stabilise them. State-of-the-science analytical and observational methods will be employed to characterise the complex mosaic of wet ice habitats, dependent on factors such as the hydrology, nutrient status, particulate content and light fields within these continually evolving ice-water-particulate-microbe systems. We will quantitatively assess why and how the fine light mineral dust particulates contained within the melting ice amplify the growth of ice algae. The particulate content and composition of different layers in the GrIS is dependent on age, and so the algae that the melting ice can support may fundamentally change over time. We look back to understand if the ice biome has changed through the Anthropocene via analyse of fjord sediments. The first draft genome of ice algae will show their key adaptations to glacier surface habitats. DEEP PURPLE looks forward by providing the critical field data sets and conceptual models of ice algal growth that will facilitate the next generation of predictive models of sea level rise due to biologically enhanced melting of the GrIS.
Max ERC Funding
11 007 344 €
Duration
Start date: 2020-01-01, End date: 2025-12-31
Project acronym GLIOGUIDE
Project Commercialising a novel glioblastoma targeted therapy and a companion diagnostic compound
Researcher (PI) Tambet TEESALU
Host Institution (HI) TARTU ULIKOOL
Country Estonia
Call Details Proof of Concept (PoC), ERC-2017-PoC
Summary Glioblastoma (GBM), is the most aggressive form of primary brain cancer and is diagnosed in 22,000 people per year in the EU. GBM is the most aggressive primary brain cancer and, by annual incidence, the most common type of malignant brain tumour. Despite aggressive treatment, the cancer always recurs. The average survival after diagnosis is 12 to 15 months, with less than 3% to 5% of patients surviving longer than 5 years. The current standard of care extends overall survival to ~14 -16 months. Current valuation of the global GBM treatment market is estimated to be €615 million per year, and it is predicted to increase to over €3.08 billion by 2024 (compound annual growth rate of 17%), based on the projected approval of new therapies including Opdivo and Optune. The main aim of this ERC PoC proposal is to probe the commercial viability of two types of tumour-targeted payload hybrids, one as an improved chemotherapeutic treatment, and the other as a precision-guided imaging agent for PET/MRI-based diagnosis. Our goal is for the former to become the clinician’s chemotherapy of choice in the adjuvant phase of GBM treatment; and for the latter to be incorporated into PET and MR-imaging procedures as a method for identifying and diagnosing GBM, as well as a companion test for stratification of patients for therapy.
Summary
Glioblastoma (GBM), is the most aggressive form of primary brain cancer and is diagnosed in 22,000 people per year in the EU. GBM is the most aggressive primary brain cancer and, by annual incidence, the most common type of malignant brain tumour. Despite aggressive treatment, the cancer always recurs. The average survival after diagnosis is 12 to 15 months, with less than 3% to 5% of patients surviving longer than 5 years. The current standard of care extends overall survival to ~14 -16 months. Current valuation of the global GBM treatment market is estimated to be €615 million per year, and it is predicted to increase to over €3.08 billion by 2024 (compound annual growth rate of 17%), based on the projected approval of new therapies including Opdivo and Optune. The main aim of this ERC PoC proposal is to probe the commercial viability of two types of tumour-targeted payload hybrids, one as an improved chemotherapeutic treatment, and the other as a precision-guided imaging agent for PET/MRI-based diagnosis. Our goal is for the former to become the clinician’s chemotherapy of choice in the adjuvant phase of GBM treatment; and for the latter to be incorporated into PET and MR-imaging procedures as a method for identifying and diagnosing GBM, as well as a companion test for stratification of patients for therapy.
Max ERC Funding
150 000 €
Duration
Start date: 2018-06-01, End date: 2019-11-30
Project acronym GLIOMADDS
Project Development of tumor penetrating peptides for glioma targeting
Researcher (PI) Tambet Teesalu
Host Institution (HI) TARTU ULIKOOL
Country Estonia
Call Details Starting Grant (StG), LS7, ERC-2011-StG_20101109
Summary This application addresses a major problem in therapy of solid tumors: poor penetration of anti-cancer drugs into tumor tissue and to infiltrating tumor cells. Recently, we have identified tumor penetrating peptides (TPP) that trigger specific penetration of co-administered un-conjugated drugs deep into tumor and increase their therapeutic index. Current TPP target angiogenic tumor vessels and may not be suitable for targeting slow-growing tumors and invasive tumor cells. TPP are composed of functional modules (tumor recruitment motif, cryptic tissue penetrating C-end Rule element, and a protease cleavage site), which can be rearranged to yield peptides of novel specificities.
Our goal is to develop TPP platform for delivery of co-administered drugs to the deadliest brain tumor – glioblastoma (GBM). High-grade glioma is a target that is particularly evasive and well-suited for tissue penetrative drug delivery. We will develop glioma-specific TPP (gTPP) by combination of in vivo and ex vivo phage display of constrained peptide libraries on state-of-the-art glioma animal models. These gTPP will be able to penetrate gliomas (and potentially other tumors) independent of their angiogenic status, and to deliver drugs to infiltrating malignant cells far from the bulk glioma lesion. We will characterize, validate, and optimize the gTPP platform for enhanced glioma delivery of co-injected drugs. These studies will provide the preclinical data needed to advance the gTPP combination therapy of glioma to GLP toxicology and subsequent IND filing.
Summary
This application addresses a major problem in therapy of solid tumors: poor penetration of anti-cancer drugs into tumor tissue and to infiltrating tumor cells. Recently, we have identified tumor penetrating peptides (TPP) that trigger specific penetration of co-administered un-conjugated drugs deep into tumor and increase their therapeutic index. Current TPP target angiogenic tumor vessels and may not be suitable for targeting slow-growing tumors and invasive tumor cells. TPP are composed of functional modules (tumor recruitment motif, cryptic tissue penetrating C-end Rule element, and a protease cleavage site), which can be rearranged to yield peptides of novel specificities.
Our goal is to develop TPP platform for delivery of co-administered drugs to the deadliest brain tumor – glioblastoma (GBM). High-grade glioma is a target that is particularly evasive and well-suited for tissue penetrative drug delivery. We will develop glioma-specific TPP (gTPP) by combination of in vivo and ex vivo phage display of constrained peptide libraries on state-of-the-art glioma animal models. These gTPP will be able to penetrate gliomas (and potentially other tumors) independent of their angiogenic status, and to deliver drugs to infiltrating malignant cells far from the bulk glioma lesion. We will characterize, validate, and optimize the gTPP platform for enhanced glioma delivery of co-injected drugs. These studies will provide the preclinical data needed to advance the gTPP combination therapy of glioma to GLP toxicology and subsequent IND filing.
Max ERC Funding
1 499 931 €
Duration
Start date: 2012-01-01, End date: 2016-12-31
Project acronym INTLAWRUSSIA
Project International Law and Non-liberal States: The Doctrine and Application of International Law in the Russian Federation
Researcher (PI) Lauri Maelksoo
Host Institution (HI) TARTU ULIKOOL
Country Estonia
Call Details Starting Grant (StG), SH2, ERC-2009-StG
Summary The central research question of our project is: what impact does the increasingly non-liberal orientation of the government of the Russian Federation have on the Russian doctrine and practice of international law? As the West and Russia hope to further build their relationship on international law, is it still the same international law that they are talking about? We aim to provide systematic empirical evidence on the use and conceptualization of international law in the Russian Federation. But we intend to go further than that. The project has also a wider theoretical ambition since we intend to analyze the situation in Russia as an example of something beyond Russia itself, namely from the viewpoint of the question of how non-liberal States understand and practice international law. Whether non-liberal States 'behave worse' in respect to international law than liberal States is one of the most important debates in the post-Cold War international legal theory. To combine these two questions - Russia and how non-liberal States relate to international law - promises ground-breaking new insights. Our method includes, beside obvious classical tools of international legal research, using IR theories of constructivism and liberalism. Moreover, we will conduct interviews with Russian judges, politicians and legal academicians in order to get a more nuanced and realistic view on the conceptualization and use of international law in Russia. Besides the PI, the research team includes two post-doc scholars at the Faculty of Law of Tartu University. Three doctoral student positions are also foreseen in the project.
Summary
The central research question of our project is: what impact does the increasingly non-liberal orientation of the government of the Russian Federation have on the Russian doctrine and practice of international law? As the West and Russia hope to further build their relationship on international law, is it still the same international law that they are talking about? We aim to provide systematic empirical evidence on the use and conceptualization of international law in the Russian Federation. But we intend to go further than that. The project has also a wider theoretical ambition since we intend to analyze the situation in Russia as an example of something beyond Russia itself, namely from the viewpoint of the question of how non-liberal States understand and practice international law. Whether non-liberal States 'behave worse' in respect to international law than liberal States is one of the most important debates in the post-Cold War international legal theory. To combine these two questions - Russia and how non-liberal States relate to international law - promises ground-breaking new insights. Our method includes, beside obvious classical tools of international legal research, using IR theories of constructivism and liberalism. Moreover, we will conduct interviews with Russian judges, politicians and legal academicians in order to get a more nuanced and realistic view on the conceptualization and use of international law in Russia. Besides the PI, the research team includes two post-doc scholars at the Faculty of Law of Tartu University. Three doctoral student positions are also foreseen in the project.
Max ERC Funding
500 000 €
Duration
Start date: 2009-09-01, End date: 2014-08-31
Project acronym INVPROB
Project Inverse Problems
Researcher (PI) Lassi Juhani Paeivaerinta
Host Institution (HI) TALLINNA TEHNIKAÜLIKOOL
Country Estonia
Call Details Advanced Grant (AdG), PE1, ERC-2010-AdG_20100224
Summary Inverse problems constitute an interdisciplinary field of science concentrating on the mathematical theory and practical interpretation of indirect measurements. Their applications include medical imaging, atmospheric remote sensing, industrial process monitoring, and astronomical imaging. The common feature is extreme sensitivity to measurement noise. Computerized tomography, MRI, and exploration of the interior of earth by using earthquake data are typical inverse problems where mathematics has played an important role. By using the methods of inverse problems it is possible to bring modern mathematics to a vast number of applied fields. Genuine scientific innovations that are found in mathematical research, say in geometry, stochastics, or analysis, can be brought to real life applications through modelling. The solutions are often found by combining recent theoretical and computational advances. The study of inverse problems is one of the most active and fastest growing areas of modern applied mathematics, and the most interdisciplinary field of mathematics or even science in general.
The exciting but high risk problems in the research plan of the PI include mathematics of invisibility cloaking, invisible patterns, practical algorithms for imaging, and random quantum systems. Progress in these problems could have a considerable impact in applications such as construction of metamaterials for invisible optic fibre cables, scopes for MRI devices, and early screening for breast cancer. The progress here necessitates international collaboration. This will be realized in upcoming programs on inverse problems. The PI is involved in organizing semester programs in inverse problems at MSRI in 2010, Isaac Newton Institute in 2011, and Mittag-Leffler -institute in 2012.
Summary
Inverse problems constitute an interdisciplinary field of science concentrating on the mathematical theory and practical interpretation of indirect measurements. Their applications include medical imaging, atmospheric remote sensing, industrial process monitoring, and astronomical imaging. The common feature is extreme sensitivity to measurement noise. Computerized tomography, MRI, and exploration of the interior of earth by using earthquake data are typical inverse problems where mathematics has played an important role. By using the methods of inverse problems it is possible to bring modern mathematics to a vast number of applied fields. Genuine scientific innovations that are found in mathematical research, say in geometry, stochastics, or analysis, can be brought to real life applications through modelling. The solutions are often found by combining recent theoretical and computational advances. The study of inverse problems is one of the most active and fastest growing areas of modern applied mathematics, and the most interdisciplinary field of mathematics or even science in general.
The exciting but high risk problems in the research plan of the PI include mathematics of invisibility cloaking, invisible patterns, practical algorithms for imaging, and random quantum systems. Progress in these problems could have a considerable impact in applications such as construction of metamaterials for invisible optic fibre cables, scopes for MRI devices, and early screening for breast cancer. The progress here necessitates international collaboration. This will be realized in upcoming programs on inverse problems. The PI is involved in organizing semester programs in inverse problems at MSRI in 2010, Isaac Newton Institute in 2011, and Mittag-Leffler -institute in 2012.
Max ERC Funding
1 800 000 €
Duration
Start date: 2011-03-01, End date: 2016-02-29
Project acronym Kerr
Project How do chiral superconductors break time-reversal symmetry? – Kerr spectroscopy study
Researcher (PI) Girsh Blumberg
Host Institution (HI) KEEMILISE JA BIOLOOGILISE FUUSIKA INSTITUUT
Country Estonia
Call Details Advanced Grant (AdG), PE3, ERC-2019-ADG
Summary Unconventional superconductivity is extensively sought for in contemporary research. Of particular interest are chiral superconductors which possess non-trivial topological properties resulting in superconducting (SC) order parameters (OPs) that may break time-reversal symmetry (TRS). The possibility of applications to topological quantum computation have placed such materials at the forefront of condensed matter research. Recent measurements of the polar Kerr effect (PKE), in which a rotation of polarization is detected for a beam of light reflected from the surface of a superconductor, have emerged as a key experimental probe of TRS breaking. Here we propose the development of a new generation of spectroscopic instrumentation for the PKE spectroscopy in the sub-THz frequency range, the energy scale that is comparable with the SC gap magnitude of unconventional superconductors. The THz range PKE spectroscopy will enable to study the broken symmetries, the origin of unconventional pairing, the in-gap collective modes, and the structures of the SC OPs. We plan to measure the PKE at sub-THz frequencies and with sub-milli-radian angular resolution from a variety of unconventional superconductors that are cooled to 100 mK, deep into SC state. The aim is to understand the basic mechanisms leading to unconventional superconductivity in these systems in order to find answers to the fundamental questions, such as: What is the structure of the SC gap in Sr2RuO4, URu2Si2, and UPt3? Is the TRS broken in (a) the Hidden Order state and in (b) SC state of URu2Si2? Which symmetries are broken at the transition from the HO state into the unconventional SC state? – and to elucidate the microscopic origin of superconductivity in the new families of unconventional superconductors. In a broader view, the project will keep Estonian physics on the forefront of science through new scientific contacts and will promote physics education by engaging students and postdocs in the research.
Summary
Unconventional superconductivity is extensively sought for in contemporary research. Of particular interest are chiral superconductors which possess non-trivial topological properties resulting in superconducting (SC) order parameters (OPs) that may break time-reversal symmetry (TRS). The possibility of applications to topological quantum computation have placed such materials at the forefront of condensed matter research. Recent measurements of the polar Kerr effect (PKE), in which a rotation of polarization is detected for a beam of light reflected from the surface of a superconductor, have emerged as a key experimental probe of TRS breaking. Here we propose the development of a new generation of spectroscopic instrumentation for the PKE spectroscopy in the sub-THz frequency range, the energy scale that is comparable with the SC gap magnitude of unconventional superconductors. The THz range PKE spectroscopy will enable to study the broken symmetries, the origin of unconventional pairing, the in-gap collective modes, and the structures of the SC OPs. We plan to measure the PKE at sub-THz frequencies and with sub-milli-radian angular resolution from a variety of unconventional superconductors that are cooled to 100 mK, deep into SC state. The aim is to understand the basic mechanisms leading to unconventional superconductivity in these systems in order to find answers to the fundamental questions, such as: What is the structure of the SC gap in Sr2RuO4, URu2Si2, and UPt3? Is the TRS broken in (a) the Hidden Order state and in (b) SC state of URu2Si2? Which symmetries are broken at the transition from the HO state into the unconventional SC state? – and to elucidate the microscopic origin of superconductivity in the new families of unconventional superconductors. In a broader view, the project will keep Estonian physics on the forefront of science through new scientific contacts and will promote physics education by engaging students and postdocs in the research.
Max ERC Funding
2 489 976 €
Duration
Start date: 2021-07-01, End date: 2026-06-30
Project acronym Phosphoprocessors
Project Biological signal processing via multisite phosphorylation networks
Researcher (PI) Mart Loog
Host Institution (HI) TARTU ULIKOOL
Country Estonia
Call Details Consolidator Grant (CoG), LS1, ERC-2014-CoG
Summary Multisite phosphorylation of proteins is a powerful signal processing mechanism playing crucial roles in cell division and differentiation as well as in disease. Our goal in this application is to elucidate the molecular basis of this important mechanism. We recently demonstrated a novel phenomenon of multisite phosphorylation in cell cycle regulation. We showed that cyclin-dependent kinase (CDK)-dependent multisite phosphorylation of a crucial substrate is performed semiprocessively in the N-to-C terminal direction along the disordered protein. The process is controlled by key parameters including the distance between phosphorylation sites, the distribution of serines and threonines in sites, and the position of docking motifs. According to our model, linear patterns of phosphorylation networks along the disordered protein segments determine the net phosphorylation rate of the protein. This concept provides a new interpretation of CDK signal processing, and it can explain how the temporal order of cell cycle events is achieved. The goals of this study are: 1) We will seek proof of the model by rewiring the patterns of budding yeast Cdk1 multisite networks according to the rules we have identified, so to change the order of cell cycle events. Next, we will restore the order by alternative wiring of the same switches; 2) To apply the proposed model in the context of different kinases and complex substrate arrangements, we will study the Cdk1-dependent multisite phosphorylation of kinetochore components, to understand the phospho-regulation of kinetochore formation, microtubule attachment and error correction; 3) We will apply multisite phosphorylation to design circuits for synthetic biology. A toolbox of synthetic parts based on multisite phosphorylation would revolutionize the field since the fast time scales and wide combinatorial possibilities.
Summary
Multisite phosphorylation of proteins is a powerful signal processing mechanism playing crucial roles in cell division and differentiation as well as in disease. Our goal in this application is to elucidate the molecular basis of this important mechanism. We recently demonstrated a novel phenomenon of multisite phosphorylation in cell cycle regulation. We showed that cyclin-dependent kinase (CDK)-dependent multisite phosphorylation of a crucial substrate is performed semiprocessively in the N-to-C terminal direction along the disordered protein. The process is controlled by key parameters including the distance between phosphorylation sites, the distribution of serines and threonines in sites, and the position of docking motifs. According to our model, linear patterns of phosphorylation networks along the disordered protein segments determine the net phosphorylation rate of the protein. This concept provides a new interpretation of CDK signal processing, and it can explain how the temporal order of cell cycle events is achieved. The goals of this study are: 1) We will seek proof of the model by rewiring the patterns of budding yeast Cdk1 multisite networks according to the rules we have identified, so to change the order of cell cycle events. Next, we will restore the order by alternative wiring of the same switches; 2) To apply the proposed model in the context of different kinases and complex substrate arrangements, we will study the Cdk1-dependent multisite phosphorylation of kinetochore components, to understand the phospho-regulation of kinetochore formation, microtubule attachment and error correction; 3) We will apply multisite phosphorylation to design circuits for synthetic biology. A toolbox of synthetic parts based on multisite phosphorylation would revolutionize the field since the fast time scales and wide combinatorial possibilities.
Max ERC Funding
1 999 289 €
Duration
Start date: 2015-05-01, End date: 2020-10-31
