Project acronym AB-SWITCH
Project Evaluation of commercial potential of a low-cost kit based on DNA-nanoswitches for the single-step measurement of diagnostic antibodies
Researcher (PI) Francesco RICCI
Host Institution (HI) UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA
Country Italy
Call Details Proof of Concept (PoC), ERC-2016-PoC, ERC-2016-PoC
Summary "Antibodies are among the most widely monitored class of diagnostic biomarkers. Immunoassays market now covers about 1/3 of the global market of in-vitro diagnostics (about $50 billion). However, current methods for the detection of diagnostic antibodies are either qualitative or require cumbersome, resource-intensive laboratory procedures that need hours to provide clinicians with diagnostic information. A new method for fast and low-cost detection of antibodies will have a strong economic impact in the market of in-vitro diagnostics and Immunoassays.
During our ERC Starting Grant project ""Nature Nanodevices"" we have developed a novel diagnostic technology for the detection of clinically relevant antibodies in serum and other body fluids. The platform (here named Ab-switch) supports the fluorescent detection of diagnostic antibodies (for example, HIV diagnostic antibodies) in a rapid (<3 minutes), single-step and low-cost fashion.
The goal of this Proof of Concept project is to bring our promising platform to the proof of diagnostic market and exploit its innovative features for commercial purposes. We will focus our initial efforts in the development of rapid kits for the detection of antibodies diagnostic of HIV. We will 1) Fully characterize the Ab-switch product in terms of analytical performances (i.e. sensitivity, specificity, stability etc.) with direct comparison with other commercial kits; 2) Prepare a Manufacturing Plan for producing/testing the Ab-switch; 3) Establish an IP strategy for patent filing and maintenance; 4) Determine a business and commercialization planning."
Summary
"Antibodies are among the most widely monitored class of diagnostic biomarkers. Immunoassays market now covers about 1/3 of the global market of in-vitro diagnostics (about $50 billion). However, current methods for the detection of diagnostic antibodies are either qualitative or require cumbersome, resource-intensive laboratory procedures that need hours to provide clinicians with diagnostic information. A new method for fast and low-cost detection of antibodies will have a strong economic impact in the market of in-vitro diagnostics and Immunoassays.
During our ERC Starting Grant project ""Nature Nanodevices"" we have developed a novel diagnostic technology for the detection of clinically relevant antibodies in serum and other body fluids. The platform (here named Ab-switch) supports the fluorescent detection of diagnostic antibodies (for example, HIV diagnostic antibodies) in a rapid (<3 minutes), single-step and low-cost fashion.
The goal of this Proof of Concept project is to bring our promising platform to the proof of diagnostic market and exploit its innovative features for commercial purposes. We will focus our initial efforts in the development of rapid kits for the detection of antibodies diagnostic of HIV. We will 1) Fully characterize the Ab-switch product in terms of analytical performances (i.e. sensitivity, specificity, stability etc.) with direct comparison with other commercial kits; 2) Prepare a Manufacturing Plan for producing/testing the Ab-switch; 3) Establish an IP strategy for patent filing and maintenance; 4) Determine a business and commercialization planning."
Max ERC Funding
150 000 €
Duration
Start date: 2017-02-01, End date: 2018-07-31
Project acronym ADMIRE
Project A holographic microscope for the immersive exploration of augmented micro-reality
Researcher (PI) Roberto DI LEONARDO
Host Institution (HI) UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA
Country Italy
Call Details Proof of Concept (PoC), ERC-2017-PoC
Summary Virtual reality, augmented reality and mixed reality are beginning to transform the way we explore and acquire information from the macroscopic world around us. At the same time, recent advances in holographic microscopy are providing new tools for the 3D imaging of physical and biological phenomena occurring at the micron scale. Project ADMIRE will combine this two emerging technologies into the first prototype of an AugmenteD MIcro-REality system for the immersive exploration and the quantitative analysis of three-dimensional processes at the micron scale.
The core of the proposed system will be the three-axis holographic microscope (3DHM) developed within the ERC Project SMART to investigate fast 3D dynamics of swimming bacteria.
ADMIRE project will transform 3DHM from a laboratory technique, targeted to a specific application and operated by highly specialised researchers into a general purpose instrument composed of a compact add-on module for commercial optical microscopes and a virtual reality interface allowing for a direct and intuitive use. Through the ADMIRE Holographic Microscope (ADMIRE-HM) the user will be “shrunk” a million times and virtually sent into a live 3D reconstruction of the real microscopic world contained in the glass slide. There he will find himself surrounded by micro-particles or moving cells that could be inspected from multiple directions and characterized by shape parameters (e.g. size, volume, aspect-ratio) or dynamical features (e.g. flagellar motility, sedimentation velocity, transport in a flow) obtained by means of simple and direct gestures.
The expected outcome of the project is to bring to a development stage TRL 6-7 a technology that could change the way we experience the microscopic world in basic research, biomedical applications and education.
Summary
Virtual reality, augmented reality and mixed reality are beginning to transform the way we explore and acquire information from the macroscopic world around us. At the same time, recent advances in holographic microscopy are providing new tools for the 3D imaging of physical and biological phenomena occurring at the micron scale. Project ADMIRE will combine this two emerging technologies into the first prototype of an AugmenteD MIcro-REality system for the immersive exploration and the quantitative analysis of three-dimensional processes at the micron scale.
The core of the proposed system will be the three-axis holographic microscope (3DHM) developed within the ERC Project SMART to investigate fast 3D dynamics of swimming bacteria.
ADMIRE project will transform 3DHM from a laboratory technique, targeted to a specific application and operated by highly specialised researchers into a general purpose instrument composed of a compact add-on module for commercial optical microscopes and a virtual reality interface allowing for a direct and intuitive use. Through the ADMIRE Holographic Microscope (ADMIRE-HM) the user will be “shrunk” a million times and virtually sent into a live 3D reconstruction of the real microscopic world contained in the glass slide. There he will find himself surrounded by micro-particles or moving cells that could be inspected from multiple directions and characterized by shape parameters (e.g. size, volume, aspect-ratio) or dynamical features (e.g. flagellar motility, sedimentation velocity, transport in a flow) obtained by means of simple and direct gestures.
The expected outcome of the project is to bring to a development stage TRL 6-7 a technology that could change the way we experience the microscopic world in basic research, biomedical applications and education.
Max ERC Funding
150 000 €
Duration
Start date: 2017-11-01, End date: 2019-04-30
Project acronym AdriArchCult
Project Architectural Culture of the Early Modern Eastern Adriatic
Researcher (PI) Jasenka Gudelj
Host Institution (HI) UNIVERSITA CA' FOSCARI VENEZIA
Country Italy
Call Details Consolidator Grant (CoG), SH5, ERC-2019-COG
Summary During the 15th century, the political process of reducing the Eastern Adriatic, here considered as encompassing what is now littoral of Slovenia, Croatia and Montenegro, to a thin strip of border territories substantially separated from the continental massive to which they belong, reached its conclusion. The insularity of its large natural archipelago, i.e. almost exclusive dependence on the maritime communications, became characteristic even of mainland coastal towns, with lasting consequences. The project explores the impact of this change in the area between 15th and 18th c., focusing on architecture as the most evident materialization of a culture and its transformations. The goal is to examine the architectural culture in question in terms of both consumption and production. Factors such as political and economic consolidation of Venetian and Dubrovnik Republics as well as Habsburg Empire in the area, war and commerce with the Ottomans, but also the quick spread of revival of antiquity and the Catholic Revival, all fuelled the need for architectural creation with certain functional and symbolic characteristics, setting the cultural standards. On the other hand, the economics of production of architecture consisted of interrelated systems of the provision of materials (esp. Istrian stone) and organisation of construction sites, which, given the ease of the sea transport, resulted in an active market for architectural goods. This approach will provide an original contribution to the understanding of cultural practices that not only produced specific buildings, the most significant among which are now listed as World Heritage sites but also put into circulation ancient and modern models, techniques and materials for a European-wide audience. Moreover, it will investigate the trans-border and trans-confessional character of the architectural market, thus providing an innovative model for a study of such phenomena across Europe.
Summary
During the 15th century, the political process of reducing the Eastern Adriatic, here considered as encompassing what is now littoral of Slovenia, Croatia and Montenegro, to a thin strip of border territories substantially separated from the continental massive to which they belong, reached its conclusion. The insularity of its large natural archipelago, i.e. almost exclusive dependence on the maritime communications, became characteristic even of mainland coastal towns, with lasting consequences. The project explores the impact of this change in the area between 15th and 18th c., focusing on architecture as the most evident materialization of a culture and its transformations. The goal is to examine the architectural culture in question in terms of both consumption and production. Factors such as political and economic consolidation of Venetian and Dubrovnik Republics as well as Habsburg Empire in the area, war and commerce with the Ottomans, but also the quick spread of revival of antiquity and the Catholic Revival, all fuelled the need for architectural creation with certain functional and symbolic characteristics, setting the cultural standards. On the other hand, the economics of production of architecture consisted of interrelated systems of the provision of materials (esp. Istrian stone) and organisation of construction sites, which, given the ease of the sea transport, resulted in an active market for architectural goods. This approach will provide an original contribution to the understanding of cultural practices that not only produced specific buildings, the most significant among which are now listed as World Heritage sites but also put into circulation ancient and modern models, techniques and materials for a European-wide audience. Moreover, it will investigate the trans-border and trans-confessional character of the architectural market, thus providing an innovative model for a study of such phenomena across Europe.
Max ERC Funding
1 999 750 €
Duration
Start date: 2020-09-01, End date: 2025-08-31
Project acronym AFDMATS
Project Anton Francesco Doni – Multimedia Archive Texts and Sources
Researcher (PI) Giovanna Rizzarelli
Host Institution (HI) SCUOLA NORMALE SUPERIORE
Country Italy
Call Details Starting Grant (StG), SH4, ERC-2007-StG
Summary This project aims at creating a multimedia archive of the printed works of Anton Francesco Doni, who was not only an author but also a typographer, a publisher and a member of the Giolito and Marcolini’s editorial staff. The analysis of Doni’s work may be a good way to investigate appropriation, text rewriting and image reusing practices which are typical of several authors of the 16th Century, as clearly shown by the critics in the last decades. This project intends to bring to light the wide range of impulses from which Doni’s texts are generated, with a great emphasis on the figurative aspect. The encoding of these texts will be carried out using the TEI (Text Encoding Initiative) guidelines, which will enable any single text to interact with a range of intertextual references both at a local level (inside the same text) and at a macrostructural level (references to other texts by Doni or to other authors). The elements that will emerge from the textual encoding concern: A) The use of images Real images: the complex relation between Doni’s writing and the xylographies available in Marcolini’s printing-house or belonging to other collections. Mental images: the remarkable presence of verbal images, as descriptions, ekphràseis, figurative visions, dreams and iconographic allusions not accompanied by illustrations, but related to a recognizable visual repertoire or to real images that will be reproduced. B) The use of sources A parallel archive of the texts most used by Doni will be created. Digital anastatic reproductions of the 16th-Century editions known by Doni will be provided whenever available. The various forms of intertextuality will be divided into the following typologies: allusions; citations; rewritings; plagiarisms; self-quotations. Finally, the different forms of narrative (tales, short stories, anecdotes, lyrics) and the different idiomatic expressions (proverbial forms and wellerisms) will also be encoded.
Summary
This project aims at creating a multimedia archive of the printed works of Anton Francesco Doni, who was not only an author but also a typographer, a publisher and a member of the Giolito and Marcolini’s editorial staff. The analysis of Doni’s work may be a good way to investigate appropriation, text rewriting and image reusing practices which are typical of several authors of the 16th Century, as clearly shown by the critics in the last decades. This project intends to bring to light the wide range of impulses from which Doni’s texts are generated, with a great emphasis on the figurative aspect. The encoding of these texts will be carried out using the TEI (Text Encoding Initiative) guidelines, which will enable any single text to interact with a range of intertextual references both at a local level (inside the same text) and at a macrostructural level (references to other texts by Doni or to other authors). The elements that will emerge from the textual encoding concern: A) The use of images Real images: the complex relation between Doni’s writing and the xylographies available in Marcolini’s printing-house or belonging to other collections. Mental images: the remarkable presence of verbal images, as descriptions, ekphràseis, figurative visions, dreams and iconographic allusions not accompanied by illustrations, but related to a recognizable visual repertoire or to real images that will be reproduced. B) The use of sources A parallel archive of the texts most used by Doni will be created. Digital anastatic reproductions of the 16th-Century editions known by Doni will be provided whenever available. The various forms of intertextuality will be divided into the following typologies: allusions; citations; rewritings; plagiarisms; self-quotations. Finally, the different forms of narrative (tales, short stories, anecdotes, lyrics) and the different idiomatic expressions (proverbial forms and wellerisms) will also be encoded.
Max ERC Funding
559 200 €
Duration
Start date: 2008-08-01, End date: 2012-07-31
Project acronym AFRICA-GHG
Project AFRICA-GHG: The role of African tropical forests on the Greenhouse Gases balance of the atmosphere
Researcher (PI) Riccardo Valentini
Host Institution (HI) FONDAZIONE CENTRO EURO-MEDITERRANEOSUI CAMBIAMENTI CLIMATICI
Country Italy
Call Details Advanced Grant (AdG), PE10, ERC-2009-AdG
Summary The role of the African continent in the global carbon cycle, and therefore in climate change, is increasingly recognised. Despite the increasingly acknowledged importance of Africa in the global carbon cycle and its high vulnerability to climate change there is still a lack of studies on the carbon cycle in representative African ecosystems (in particular tropical forests), and on the effects of climate on ecosystem-atmosphere exchange. In the present proposal we want to focus on these spoecifc objectives : 1. Understand the role of African tropical rainforest on the GHG balance of the atmosphere and revise their role on the global methane and N2O emissions. 2. Determine the carbon source/sink strength of African tropical rainforest in the pre-industrial versus the XXth century by temporal reconstruction of biomass growth with biogeochemical markers 3. Understand and quantify carbon and GHG fluxes variability across African tropical forests (west east equatorial belt) 4.Analyse the impact of forest degradation and deforestation on carbon and other GHG emissions
Summary
The role of the African continent in the global carbon cycle, and therefore in climate change, is increasingly recognised. Despite the increasingly acknowledged importance of Africa in the global carbon cycle and its high vulnerability to climate change there is still a lack of studies on the carbon cycle in representative African ecosystems (in particular tropical forests), and on the effects of climate on ecosystem-atmosphere exchange. In the present proposal we want to focus on these spoecifc objectives : 1. Understand the role of African tropical rainforest on the GHG balance of the atmosphere and revise their role on the global methane and N2O emissions. 2. Determine the carbon source/sink strength of African tropical rainforest in the pre-industrial versus the XXth century by temporal reconstruction of biomass growth with biogeochemical markers 3. Understand and quantify carbon and GHG fluxes variability across African tropical forests (west east equatorial belt) 4.Analyse the impact of forest degradation and deforestation on carbon and other GHG emissions
Max ERC Funding
2 406 950 €
Duration
Start date: 2010-04-01, End date: 2014-12-31
Project acronym AGEnTh
Project Atomic Gauge and Entanglement Theories
Researcher (PI) Marcello DALMONTE
Host Institution (HI) SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI DI TRIESTE
Country Italy
Call Details Starting Grant (StG), PE2, ERC-2017-STG
Summary AGEnTh is an interdisciplinary proposal which aims at theoretically investigating atomic many-body systems (cold atoms and trapped ions) in close connection to concepts from quantum information, condensed matter, and high energy physics. The main goals of this programme are to:
I) Find to scalable schemes for the measurements of entanglement properties, and in particular entanglement spectra, by proposing a shifting paradigm to access entanglement focused on entanglement Hamiltonians and field theories instead of probing density matrices;
II) Show how atomic gauge theories (including dynamical gauge fields) are ideal candidates for the realization of long-sought, highly-entangled states of matter, in particular topological superconductors supporting parafermion edge modes, and novel classes of quantum spin liquids emerging from clustering;
III) Develop new implementation strategies for the realization of gauge symmetries of paramount importance, such as discrete and SU(N)xSU(2)xU(1) groups, and establish a theoretical framework for the understanding of atomic physics experiments within the light-from-chaos scenario pioneered in particle physics.
These objectives are at the cutting-edge of fundamental science, and represent a coherent effort aimed at underpinning unprecedented regimes of strongly interacting quantum matter by addressing the basic aspects of probing, many-body physics, and implementations. The results are expected to (i) build up and establish qualitatively new synergies between the aforementioned communities, and (ii) stimulate an intense theoretical and experimental activity focused on both entanglement and atomic gauge theories.
In order to achieve those, AGEnTh builds: (1) on my background working at the interface between atomic physics and quantum optics from one side, and many-body theory on the other, and (2) on exploratory studies which I carried out to mitigate the conceptual risks associated with its high-risk/high-gain goals.
Summary
AGEnTh is an interdisciplinary proposal which aims at theoretically investigating atomic many-body systems (cold atoms and trapped ions) in close connection to concepts from quantum information, condensed matter, and high energy physics. The main goals of this programme are to:
I) Find to scalable schemes for the measurements of entanglement properties, and in particular entanglement spectra, by proposing a shifting paradigm to access entanglement focused on entanglement Hamiltonians and field theories instead of probing density matrices;
II) Show how atomic gauge theories (including dynamical gauge fields) are ideal candidates for the realization of long-sought, highly-entangled states of matter, in particular topological superconductors supporting parafermion edge modes, and novel classes of quantum spin liquids emerging from clustering;
III) Develop new implementation strategies for the realization of gauge symmetries of paramount importance, such as discrete and SU(N)xSU(2)xU(1) groups, and establish a theoretical framework for the understanding of atomic physics experiments within the light-from-chaos scenario pioneered in particle physics.
These objectives are at the cutting-edge of fundamental science, and represent a coherent effort aimed at underpinning unprecedented regimes of strongly interacting quantum matter by addressing the basic aspects of probing, many-body physics, and implementations. The results are expected to (i) build up and establish qualitatively new synergies between the aforementioned communities, and (ii) stimulate an intense theoretical and experimental activity focused on both entanglement and atomic gauge theories.
In order to achieve those, AGEnTh builds: (1) on my background working at the interface between atomic physics and quantum optics from one side, and many-body theory on the other, and (2) on exploratory studies which I carried out to mitigate the conceptual risks associated with its high-risk/high-gain goals.
Max ERC Funding
1 055 317 €
Duration
Start date: 2018-05-01, End date: 2023-04-30
Project acronym AIDA
Project An Illumination of the Dark Ages: modeling reionization and interpreting observations
Researcher (PI) Andrei Albert Mesinger
Host Institution (HI) SCUOLA NORMALE SUPERIORE
Country Italy
Call Details Starting Grant (StG), PE9, ERC-2014-STG
Summary "Understanding the dawn of the first galaxies and how their light permeated the early Universe is at the very frontier of modern astrophysical cosmology. Generous resources, including ambitions observational programs, are being devoted to studying these epochs of Cosmic Dawn (CD) and Reionization (EoR). In order to interpret these observations, we propose to build on our widely-used, semi-numeric simulation tool, 21cmFAST, and apply it to observations. Using sub-grid, semi-analytic models, we will incorporate additional physical processes governing the evolution of sources and sinks of ionizing photons. The resulting state-of-the-art simulations will be well poised to interpret topical observations of quasar spectra and the cosmic 21cm signal. They would be both physically-motivated and fast, allowing us to rapidly explore astrophysical parameter space. We will statistically quantify the resulting degeneracies and constraints, providing a robust answer to the question, ""What can we learn from EoR/CD observations?"" As an end goal, these investigations will help us understand when the first generations of galaxies formed, how they drove the EoR, and what are the associated large-scale observational signatures."
Summary
"Understanding the dawn of the first galaxies and how their light permeated the early Universe is at the very frontier of modern astrophysical cosmology. Generous resources, including ambitions observational programs, are being devoted to studying these epochs of Cosmic Dawn (CD) and Reionization (EoR). In order to interpret these observations, we propose to build on our widely-used, semi-numeric simulation tool, 21cmFAST, and apply it to observations. Using sub-grid, semi-analytic models, we will incorporate additional physical processes governing the evolution of sources and sinks of ionizing photons. The resulting state-of-the-art simulations will be well poised to interpret topical observations of quasar spectra and the cosmic 21cm signal. They would be both physically-motivated and fast, allowing us to rapidly explore astrophysical parameter space. We will statistically quantify the resulting degeneracies and constraints, providing a robust answer to the question, ""What can we learn from EoR/CD observations?"" As an end goal, these investigations will help us understand when the first generations of galaxies formed, how they drove the EoR, and what are the associated large-scale observational signatures."
Max ERC Funding
1 468 750 €
Duration
Start date: 2015-05-01, End date: 2021-04-30
Project acronym AISENS
Project New generation of high sensitive atom interferometers
Researcher (PI) Marco Fattori
Host Institution (HI) CONSIGLIO NAZIONALE DELLE RICERCHE
Country Italy
Call Details Starting Grant (StG), PE2, ERC-2010-StG_20091028
Summary Interferometers are fundamental tools for the study of nature laws and for the precise measurement and control of the physical world. In the last century, the scientific and technological progress has proceeded in parallel with a constant improvement of interferometric performances. For this reason, the challenge of conceiving and realizing new generations of interferometers with broader ranges of operation and with higher sensitivities is always open and actual.
Despite the introduction of laser devices has deeply improved the way of developing and performing interferometric measurements with light, the atomic matter wave analogous, i.e. the Bose-Einstein condensate (BEC), has not yet triggered any revolution in precision interferometry. However, thanks to recent improvements on the control of the quantum properties of ultra-cold atomic gases, and new original ideas on the creation and manipulation of quantum entangled particles, the field of atom interferometry is now mature to experience a big step forward.
The system I want to realize is a Mach-Zehnder spatial interferometer operating with trapped BECs. Undesired decoherence sources will be suppressed by implementing BECs with tunable interactions in ultra-stable optical potentials. Entangled states will be used to improve the sensitivity of the sensor beyond the standard quantum limit to ideally reach the ultimate, Heisenberg, limit set by quantum mechanics. The resulting apparatus will show unprecedented spatial resolution and will overcome state-of-the-art interferometers with cold (non condensed) atomic gases.
A successful completion of this project will lead to a new generation of interferometers for the immediate application to local inertial measurements with unprecedented resolution. In addition, we expect to develop experimental capabilities which might find application well beyond quantum interferometry and crucially contribute to the broader emerging field of quantum-enhanced technologies.
Summary
Interferometers are fundamental tools for the study of nature laws and for the precise measurement and control of the physical world. In the last century, the scientific and technological progress has proceeded in parallel with a constant improvement of interferometric performances. For this reason, the challenge of conceiving and realizing new generations of interferometers with broader ranges of operation and with higher sensitivities is always open and actual.
Despite the introduction of laser devices has deeply improved the way of developing and performing interferometric measurements with light, the atomic matter wave analogous, i.e. the Bose-Einstein condensate (BEC), has not yet triggered any revolution in precision interferometry. However, thanks to recent improvements on the control of the quantum properties of ultra-cold atomic gases, and new original ideas on the creation and manipulation of quantum entangled particles, the field of atom interferometry is now mature to experience a big step forward.
The system I want to realize is a Mach-Zehnder spatial interferometer operating with trapped BECs. Undesired decoherence sources will be suppressed by implementing BECs with tunable interactions in ultra-stable optical potentials. Entangled states will be used to improve the sensitivity of the sensor beyond the standard quantum limit to ideally reach the ultimate, Heisenberg, limit set by quantum mechanics. The resulting apparatus will show unprecedented spatial resolution and will overcome state-of-the-art interferometers with cold (non condensed) atomic gases.
A successful completion of this project will lead to a new generation of interferometers for the immediate application to local inertial measurements with unprecedented resolution. In addition, we expect to develop experimental capabilities which might find application well beyond quantum interferometry and crucially contribute to the broader emerging field of quantum-enhanced technologies.
Max ERC Funding
1 068 000 €
Duration
Start date: 2011-01-01, End date: 2015-12-31
Project acronym AlchemEast
Project Alchemy in the Making: From ancient Babylonia via Graeco-Roman Egypt into the Byzantine, Syriac and Arabic traditions (1500 BCE - 1000 AD)
Researcher (PI) Matteo MARTELLI
Host Institution (HI) ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA
Country Italy
Call Details Consolidator Grant (CoG), SH5, ERC-2016-COG
Summary "The AlchemEast project is devoted to the study of alchemical theory and practice as it appeared and developed in distinct, albeit contiguous (both chronologically and geographically) areas: Graeco-Roman Egypt, Byzantium, and the Near East, from Ancient Babylonian times to the early Islamic Period. This project combines innovative textual investigations with experimental replications of ancient alchemical procedures. It uses sets of historically and philologically informed laboratory replications in order to reconstruct the actual practice of ancient alchemists, and it studies the texts and literary forms in which this practice was conceptualized and transmitted. It proposes new models for textual criticism in order to capture the fluidity of the transmission of ancient alchemical writings. AlchemEast is designed to carry out a comparative investigation of cuneiform tablets as well as a vast corpus of Greek, Syriac and Arabic writings. It will overcome the old, pejorative paradigm that dismissed ancient alchemy as a ""pseudo-science"", by proposing a new theoretical framework for comprehending the entirety of ancient alchemical practices and theories. Alongside established forms of scholarly output, such as critical editions of key texts, AlchemEast will provide an integrative, longue durée perspective on the many different phases of ancient alchemy. It will thus offer a radically new vision of this discipline as a dynamic and diversified art that developed across different technical and scholastic traditions. This new representation will allow us to connect ancient alchemy with medieval and early modern alchemy and thus fully reintegrate ancient alchemy in the history of pre-modern alchemy as well as in the history of ancient science more broadly."
Summary
"The AlchemEast project is devoted to the study of alchemical theory and practice as it appeared and developed in distinct, albeit contiguous (both chronologically and geographically) areas: Graeco-Roman Egypt, Byzantium, and the Near East, from Ancient Babylonian times to the early Islamic Period. This project combines innovative textual investigations with experimental replications of ancient alchemical procedures. It uses sets of historically and philologically informed laboratory replications in order to reconstruct the actual practice of ancient alchemists, and it studies the texts and literary forms in which this practice was conceptualized and transmitted. It proposes new models for textual criticism in order to capture the fluidity of the transmission of ancient alchemical writings. AlchemEast is designed to carry out a comparative investigation of cuneiform tablets as well as a vast corpus of Greek, Syriac and Arabic writings. It will overcome the old, pejorative paradigm that dismissed ancient alchemy as a ""pseudo-science"", by proposing a new theoretical framework for comprehending the entirety of ancient alchemical practices and theories. Alongside established forms of scholarly output, such as critical editions of key texts, AlchemEast will provide an integrative, longue durée perspective on the many different phases of ancient alchemy. It will thus offer a radically new vision of this discipline as a dynamic and diversified art that developed across different technical and scholastic traditions. This new representation will allow us to connect ancient alchemy with medieval and early modern alchemy and thus fully reintegrate ancient alchemy in the history of pre-modern alchemy as well as in the history of ancient science more broadly."
Max ERC Funding
1 997 000 €
Duration
Start date: 2017-12-01, End date: 2022-11-30
Project acronym ALKVAX
Project Market potentials of ALK vaccination as a new strategy for the cure of ALK positive tumors such as lymphoma, lung carcinoma and neuroblastoma
Researcher (PI) Roberto CHIARLE
Host Institution (HI) UNIVERSITA DEGLI STUDI DI TORINO
Country Italy
Call Details Proof of Concept (PoC), PC1, ERC-2012-PoC
Summary ALK positive cancer such as Anaplastic Large Cell Lymphoma (ALCL), Non small Cell Lung Carcinoma (NSCLC) and neuroblastoma are important cancers of children and adults, currently treated with standard chemotherapy and radiotherapy, with unpredicatable and poor results, in particular in the case of NSCLC and neuroblastoma. In August 2011, the US Food and Drug Administration (FDA) had an accelerated approval of a novel drug (called Crizotinib) to treat NSCLC that express abnormal ALK protein. Phase II and III clinical trials are ongoing to test the same drug in ALCL and neuroblastoma. However, it is now clear that the treatment with Crizotinib has a good initial efficacy and response, but the cancer inevitably relapses because of the occurrence of drug resistance. This resistance is due to selection of ALK point mutants that no longer bind the inhibitor. New drugs to tame the resistant cells will be probably developed in the future (as happened for Gleevec and second and third generation of BCR-ABL inhibitors), but it is expected that again resistance will emerge.
As part of a research conducted under an ERC Starting Grat, we developed a new therapy for ALK positive ALCL, NSCLC and neuroblastoma based on the generation of a potent and specific anti-tumor response based on the development of an ALK-targeted immune response. This specific anti-ALK immune response is achieved by an anti-ALK vaccination in preclinical mouse models of ALCL and NSCLC. Now, in this Proof-of-Concept grant, we propose to take the next steps to move our invention toward a clinical application in human patients, by testing GLP formulations of the vaccine, its potential toxic effects and by searching the market for companies interested in its development and commercialization. Our goal is to understand and finalize the best strategy to move this experimental therapy to the market and generate a partnership with a pharma company.
Summary
ALK positive cancer such as Anaplastic Large Cell Lymphoma (ALCL), Non small Cell Lung Carcinoma (NSCLC) and neuroblastoma are important cancers of children and adults, currently treated with standard chemotherapy and radiotherapy, with unpredicatable and poor results, in particular in the case of NSCLC and neuroblastoma. In August 2011, the US Food and Drug Administration (FDA) had an accelerated approval of a novel drug (called Crizotinib) to treat NSCLC that express abnormal ALK protein. Phase II and III clinical trials are ongoing to test the same drug in ALCL and neuroblastoma. However, it is now clear that the treatment with Crizotinib has a good initial efficacy and response, but the cancer inevitably relapses because of the occurrence of drug resistance. This resistance is due to selection of ALK point mutants that no longer bind the inhibitor. New drugs to tame the resistant cells will be probably developed in the future (as happened for Gleevec and second and third generation of BCR-ABL inhibitors), but it is expected that again resistance will emerge.
As part of a research conducted under an ERC Starting Grat, we developed a new therapy for ALK positive ALCL, NSCLC and neuroblastoma based on the generation of a potent and specific anti-tumor response based on the development of an ALK-targeted immune response. This specific anti-ALK immune response is achieved by an anti-ALK vaccination in preclinical mouse models of ALCL and NSCLC. Now, in this Proof-of-Concept grant, we propose to take the next steps to move our invention toward a clinical application in human patients, by testing GLP formulations of the vaccine, its potential toxic effects and by searching the market for companies interested in its development and commercialization. Our goal is to understand and finalize the best strategy to move this experimental therapy to the market and generate a partnership with a pharma company.
Max ERC Funding
149 939 €
Duration
Start date: 2013-06-01, End date: 2014-05-31