Project acronym ADDICTION
Project Beyond the Genetics of Addiction
Researcher (PI) Jacqueline Mignon Vink
Host Institution (HI) STICHTING KATHOLIEKE UNIVERSITEIT
Call Details Starting Grant (StG), SH4, ERC-2011-StG_20101124
Summary My proposal seeks to explain the complex interplay between genetic and environmental causes of individual variation in substance use and the risk for abuse. Substance use is common. Substances like nicotine and cannabis have well-known negative health consequences, while alcohol and caffeine use may be both beneficial and detrimental, depending on quantity and frequency of use. Twin studies (including my own) demonstrated that both heritable and environmental factors play a role.
My proposal on substance use (nicotine, alcohol, cannabis and caffeine) is organized around several key objectives: 1. To unravel the complex contribution of genetic and environmental factors to substance use by using extended twin family designs; 2. To identify and confirm genes and gene networks involved in substance use by using DNA-variant data; 3. To explore gene expression patterns with RNA data in substance users versus non-users; 4. To investigate biomarkers in substance users versus non-users using blood or urine; 5. To unravel relation between substance use and health by linking twin-family data to national medical databases.
To realize these aims I will use the extensive resources of the Netherlands Twin Register (NTR); including both the longitudinal phenotype database and the biological samples. I have been involved in data collection, coordination of data collection and analyzing NTR data since 1999. With my comprehensive experience in data collection, data analyses and my knowledge in the field of behavior genetics and addiction research I will be able to successfully lead this cutting-edge project. Additional data crucial for the project will be collected by my team. Large samples will be available for this study and state-of-the art methods will be used to analyze the data. All together, my project will offer powerful approaches to unravel the complex interaction between genetic and environmental causes of individual differences in substance use and the risk for abuse.
Summary
My proposal seeks to explain the complex interplay between genetic and environmental causes of individual variation in substance use and the risk for abuse. Substance use is common. Substances like nicotine and cannabis have well-known negative health consequences, while alcohol and caffeine use may be both beneficial and detrimental, depending on quantity and frequency of use. Twin studies (including my own) demonstrated that both heritable and environmental factors play a role.
My proposal on substance use (nicotine, alcohol, cannabis and caffeine) is organized around several key objectives: 1. To unravel the complex contribution of genetic and environmental factors to substance use by using extended twin family designs; 2. To identify and confirm genes and gene networks involved in substance use by using DNA-variant data; 3. To explore gene expression patterns with RNA data in substance users versus non-users; 4. To investigate biomarkers in substance users versus non-users using blood or urine; 5. To unravel relation between substance use and health by linking twin-family data to national medical databases.
To realize these aims I will use the extensive resources of the Netherlands Twin Register (NTR); including both the longitudinal phenotype database and the biological samples. I have been involved in data collection, coordination of data collection and analyzing NTR data since 1999. With my comprehensive experience in data collection, data analyses and my knowledge in the field of behavior genetics and addiction research I will be able to successfully lead this cutting-edge project. Additional data crucial for the project will be collected by my team. Large samples will be available for this study and state-of-the art methods will be used to analyze the data. All together, my project will offer powerful approaches to unravel the complex interaction between genetic and environmental causes of individual differences in substance use and the risk for abuse.
Max ERC Funding
1 491 964 €
Duration
Start date: 2011-12-01, End date: 2017-05-31
Project acronym AFFORDS-HIGHER
Project Skilled Intentionality for 'Higher' Embodied Cognition: Joining forces with a field of affordances in flux
Researcher (PI) Dirk Willem Rietveld
Host Institution (HI) ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Call Details Starting Grant (StG), SH4, ERC-2015-STG
Summary In many situations experts act adequately, yet without deliberation. Architects e.g, immediately sense opportunities offered by the site of a new project. One could label these manifestations of expert intuition as ‘higher-level’ cognition, but still these experts act unreflectively. The aim of my project is to develop the Skilled Intentionality Framework (SIF), a new conceptual framework for the field of embodied/enactive cognitive science (Chemero, 2009; Thompson, 2007). I argue that affordances - possibilities for action provided by our surroundings - are highly significant in cases of unreflective and reflective ‘higher’ cognition. Skilled Intentionality is skilled coordination with multiple affordances simultaneously.
The two central ideas behind this proposal are (a) that episodes of skilled ‘higher’ cognition can be understood as responsiveness to affordances for ‘higher’ cognition and (b) that our surroundings are highly resourceful and contribute to skillful action and cognition in a far more fundamental way than is generally acknowledged. I use embedded philosophical research in a particular practice of architecture to shed new light on the ways in which affordances for ‘higher’ cognition support creative imagination, anticipation, explicit planning and self-reflection.
The Skilled Intentionality Framework is groundbreaking in relating findings established at several complementary levels of analysis: philosophy/phenomenology, ecological psychology, affective science and neurodynamics.
Empirical findings thought to be exclusively valid for everyday unreflective action can now be used to explain skilled ‘higher’ cognition as well. Moreover, SIF brings both the context and the social back into cognitive science. I will show SIF’s relevance for Friston’s work on the anticipating brain, and apply it in the domain of architecture and public health. SIF will radically widen the scope of the increasingly influential field of embodied cognitive science.
Summary
In many situations experts act adequately, yet without deliberation. Architects e.g, immediately sense opportunities offered by the site of a new project. One could label these manifestations of expert intuition as ‘higher-level’ cognition, but still these experts act unreflectively. The aim of my project is to develop the Skilled Intentionality Framework (SIF), a new conceptual framework for the field of embodied/enactive cognitive science (Chemero, 2009; Thompson, 2007). I argue that affordances - possibilities for action provided by our surroundings - are highly significant in cases of unreflective and reflective ‘higher’ cognition. Skilled Intentionality is skilled coordination with multiple affordances simultaneously.
The two central ideas behind this proposal are (a) that episodes of skilled ‘higher’ cognition can be understood as responsiveness to affordances for ‘higher’ cognition and (b) that our surroundings are highly resourceful and contribute to skillful action and cognition in a far more fundamental way than is generally acknowledged. I use embedded philosophical research in a particular practice of architecture to shed new light on the ways in which affordances for ‘higher’ cognition support creative imagination, anticipation, explicit planning and self-reflection.
The Skilled Intentionality Framework is groundbreaking in relating findings established at several complementary levels of analysis: philosophy/phenomenology, ecological psychology, affective science and neurodynamics.
Empirical findings thought to be exclusively valid for everyday unreflective action can now be used to explain skilled ‘higher’ cognition as well. Moreover, SIF brings both the context and the social back into cognitive science. I will show SIF’s relevance for Friston’s work on the anticipating brain, and apply it in the domain of architecture and public health. SIF will radically widen the scope of the increasingly influential field of embodied cognitive science.
Max ERC Funding
1 499 850 €
Duration
Start date: 2016-05-01, End date: 2021-04-30
Project acronym BAYES OR BUST!
Project Bayes or Bust: Sensible Hypothesis Tests for Social Scientists
Researcher (PI) Eric-Jan Wagenmakers
Host Institution (HI) UNIVERSITEIT VAN AMSTERDAM
Call Details Starting Grant (StG), SH4, ERC-2011-StG_20101124
Summary The goal of this proposal is to develop and promote Bayesian hypothesis tests for social scientists. By and large, social scientists have ignored the Bayesian revolution in statistics, and, consequently, most social scientists still assess the veracity of experimental effects using the same methodology that was used by their advisors and the advisors before them. This state of affairs is undesirable: social scientists conduct groundbreaking, innovative research only to analyze their results using methods that are old-fashioned or even inappropriate. This imbalance between the science and the statistics has gradually increased the pressure on the field to change the way inferences are drawn from their data. However, three requirements need to be fulfilled before social scientists are ready to adopt Bayesian tests of hypotheses. First, the Bayesian tests need to be developed for problems that social scientists work with on a regular basis; second, the Bayesian tests need to be default or objective; and, third, the Bayesian tests need to be available in a user-friendly computer program. This proposal seeks to make major progress on all three fronts.
Concretely, the projects in this proposal build on recent developments in the field of statistics and use the default Jeffreys-Zellner-Siow priors to compute Bayesian hypothesis tests for regression, correlation, the t-test, and different versions of analysis of variance (ANOVA). A similar approach will be used to develop Bayesian hypothesis tests for logistic regression and the analysis of contingency tables, as well as for popular latent process methods such as factor analysis and structural equation modeling. We aim to implement the various tests in a new computer program, Bayes-SPSS, with a similar look and feel as the frequentist spreadsheet program SPSS (i.e., Statistical Package for the Social Sciences). Together, these projects may help revolutionize the way social scientists analyze their data.
Summary
The goal of this proposal is to develop and promote Bayesian hypothesis tests for social scientists. By and large, social scientists have ignored the Bayesian revolution in statistics, and, consequently, most social scientists still assess the veracity of experimental effects using the same methodology that was used by their advisors and the advisors before them. This state of affairs is undesirable: social scientists conduct groundbreaking, innovative research only to analyze their results using methods that are old-fashioned or even inappropriate. This imbalance between the science and the statistics has gradually increased the pressure on the field to change the way inferences are drawn from their data. However, three requirements need to be fulfilled before social scientists are ready to adopt Bayesian tests of hypotheses. First, the Bayesian tests need to be developed for problems that social scientists work with on a regular basis; second, the Bayesian tests need to be default or objective; and, third, the Bayesian tests need to be available in a user-friendly computer program. This proposal seeks to make major progress on all three fronts.
Concretely, the projects in this proposal build on recent developments in the field of statistics and use the default Jeffreys-Zellner-Siow priors to compute Bayesian hypothesis tests for regression, correlation, the t-test, and different versions of analysis of variance (ANOVA). A similar approach will be used to develop Bayesian hypothesis tests for logistic regression and the analysis of contingency tables, as well as for popular latent process methods such as factor analysis and structural equation modeling. We aim to implement the various tests in a new computer program, Bayes-SPSS, with a similar look and feel as the frequentist spreadsheet program SPSS (i.e., Statistical Package for the Social Sciences). Together, these projects may help revolutionize the way social scientists analyze their data.
Max ERC Funding
1 498 286 €
Duration
Start date: 2012-05-01, End date: 2017-04-30
Project acronym BLENDS
Project Between Direct and Indirect Discourse: Shifting Perspective in Blended Discourse
Researcher (PI) Emar Maier
Host Institution (HI) RIJKSUNIVERSITEIT GRONINGEN
Call Details Starting Grant (StG), SH4, ERC-2010-StG_20091209
Summary A fundamental feature of language is that it allows us to reproduce what others have said. It is traditionally assumed that there
are two ways of doing this: direct discourse, where you preserve the original speech act verbatim, and indirect discourse,
where you paraphrase it in your own words. In accordance with this dichotomy, linguists have posited a number of universal
characteristics to distinguish the two modes. At the same time, we are seeing more and more examples that seem to fall
somewhere in between. I reject the direct indirect distinction and replace it with a new paradigm of blended discourse.
Combining insights from philosophy and linguistics, my framework has only one kind of speech reporting, in which a speaker
always attempts to convey the content of the reported words from her own perspective, but can quote certain parts verbatim,
thereby effectively switching to the reported perspective.
To explain why some languages are shiftier than others, I hypothesize that a greater distance from face-to-face
communication, with the possibility of extra- and paralinguistic perspective marking, necessitated the introduction of
an artificial direct indirect separation. I test this hypothesis by investigating languages that are closely tied to direct
communication: Dutch child language, as recent studies hint at a very late acquisition of the direct indirect distinction; Dutch
Sign Language, which has a special role shift marker that bears a striking resemblance to the quotational shift of blended
discourse; and Ancient Greek, where philologists have long been observing perspective shifts.
In sum, my research combines a new philosophical insight on the nature of reported speech with formal semantic rigor and
linguistic data from child language experiments, native signers, and Greek philology.
Summary
A fundamental feature of language is that it allows us to reproduce what others have said. It is traditionally assumed that there
are two ways of doing this: direct discourse, where you preserve the original speech act verbatim, and indirect discourse,
where you paraphrase it in your own words. In accordance with this dichotomy, linguists have posited a number of universal
characteristics to distinguish the two modes. At the same time, we are seeing more and more examples that seem to fall
somewhere in between. I reject the direct indirect distinction and replace it with a new paradigm of blended discourse.
Combining insights from philosophy and linguistics, my framework has only one kind of speech reporting, in which a speaker
always attempts to convey the content of the reported words from her own perspective, but can quote certain parts verbatim,
thereby effectively switching to the reported perspective.
To explain why some languages are shiftier than others, I hypothesize that a greater distance from face-to-face
communication, with the possibility of extra- and paralinguistic perspective marking, necessitated the introduction of
an artificial direct indirect separation. I test this hypothesis by investigating languages that are closely tied to direct
communication: Dutch child language, as recent studies hint at a very late acquisition of the direct indirect distinction; Dutch
Sign Language, which has a special role shift marker that bears a striking resemblance to the quotational shift of blended
discourse; and Ancient Greek, where philologists have long been observing perspective shifts.
In sum, my research combines a new philosophical insight on the nature of reported speech with formal semantic rigor and
linguistic data from child language experiments, native signers, and Greek philology.
Max ERC Funding
677 254 €
Duration
Start date: 2011-03-01, End date: 2016-08-31
Project acronym BOYS WILL BE BOYS?
Project Boys will be boys? Gender differences in the socialization of disruptive behaviour in early childhood
Researcher (PI) Judit Mesman
Host Institution (HI) UNIVERSITEIT LEIDEN
Call Details Starting Grant (StG), SH4, ERC-2009-StG
Summary The aim of the proposed project is to shed light on early childhood gender-differentiated socialization and gender-specific susceptibility to parenting within families in relation to disruptive behaviour in boys and girls in the first four years of life. The popular saying boys will be boys refers to the observation that boys show more disruptive behaviours (e.g., noncompliance or aggression) than girls, a pattern that has been confirmed frequently in scientific research. There is also evidence that parents treat boys differently from girls in ways that are likely to foster boys disruptive behaviour, and that boys are more susceptible to problematic family functioning than girls. The crucial question is whether gender differences in socialization, susceptibility to socialization, and children s behavioural outcomes are also salient when the same parents are doing the parenting of both a boy and a girl. Within-family comparisons are necessary to account for structural differences between families. To this end, families with two children born 22-26 months apart will be recruited from the general population. To account for birth order and gender-combination effects, the sample includes four groups of 150 families each, with the following sibling combinations: girl-boy, boy-girl, girl-girl, and boy-boy. The study has a four-wave longitudinal design, based on the youngest sibling with assessments at ages 12, 24, 36, and 48 months, because gender differences in disruptive behaviour develop during the toddler years. Each assessment consists of two home visits: one with mother and one with father, including observations of both children and of the children separately. Parenting behaviours will be studied in reaction to specific child behaviours, including aggression, noncompliance, and prosocial behaviours.
Summary
The aim of the proposed project is to shed light on early childhood gender-differentiated socialization and gender-specific susceptibility to parenting within families in relation to disruptive behaviour in boys and girls in the first four years of life. The popular saying boys will be boys refers to the observation that boys show more disruptive behaviours (e.g., noncompliance or aggression) than girls, a pattern that has been confirmed frequently in scientific research. There is also evidence that parents treat boys differently from girls in ways that are likely to foster boys disruptive behaviour, and that boys are more susceptible to problematic family functioning than girls. The crucial question is whether gender differences in socialization, susceptibility to socialization, and children s behavioural outcomes are also salient when the same parents are doing the parenting of both a boy and a girl. Within-family comparisons are necessary to account for structural differences between families. To this end, families with two children born 22-26 months apart will be recruited from the general population. To account for birth order and gender-combination effects, the sample includes four groups of 150 families each, with the following sibling combinations: girl-boy, boy-girl, girl-girl, and boy-boy. The study has a four-wave longitudinal design, based on the youngest sibling with assessments at ages 12, 24, 36, and 48 months, because gender differences in disruptive behaviour develop during the toddler years. Each assessment consists of two home visits: one with mother and one with father, including observations of both children and of the children separately. Parenting behaviours will be studied in reaction to specific child behaviours, including aggression, noncompliance, and prosocial behaviours.
Max ERC Funding
1 611 970 €
Duration
Start date: 2010-02-01, End date: 2015-03-31
Project acronym BRAINBALANCE
Project Rebalancing the brain:
Guiding brain recovery after stroke
Researcher (PI) Alexander Thomas Sack
Host Institution (HI) UNIVERSITEIT MAASTRICHT
Call Details Starting Grant (StG), SH4, ERC-2010-StG_20091209
Summary Damage to parietal cortex after stroke causes patients to become unaware of large parts of their surroundings and body parts. This so-called spatial neglect is hypothesised to be brought about by a stroke-induced imbalance between the left and right hemisphere. Some patients experience a partial recovery of lost abilities, but the factors that drive this rebalancing are unknown. The research proposed here will overcome this bottleneck in our understanding of the brain recovery phenomenon, and develop therapeutic approaches that for the first time will control, steer and speed up brain rebalancing after stroke. To that goal, we introduce a revolutionary approach in which TMS, fMRI, and EEG are applied simultaneously in healthy human volunteers to artificially unbalance the brain, and then study and control processes of rebalancing. Because we are one of the few groups worldwide that has accomplished this methodology, and that has the expertise to fully analyse the data it will yield, we are in a unique position to deliver both fundamental insights into brain plasticity, and derived new therapies. In brief, we will use TMS to (i) mimic spatial neglect in healthy volunteers while simultaneously monitoring the underlying neural network effects using fMRI/EEG, and to (ii) determine which exact brain reorganisation leads to an optimal behavioral recovery after injury. Importantly, we will use cutting-edge fMRI pattern recognition and machine learning algorithms to predict which concrete TMS treatment will specifically support this optimal functional reorganisation in the unbalanced brain. Finally, we will directly translate these fundamental findings into clinical practise and apply novel TMS protocols to rebalance the brain in patients suffering from parietal stroke.
Summary
Damage to parietal cortex after stroke causes patients to become unaware of large parts of their surroundings and body parts. This so-called spatial neglect is hypothesised to be brought about by a stroke-induced imbalance between the left and right hemisphere. Some patients experience a partial recovery of lost abilities, but the factors that drive this rebalancing are unknown. The research proposed here will overcome this bottleneck in our understanding of the brain recovery phenomenon, and develop therapeutic approaches that for the first time will control, steer and speed up brain rebalancing after stroke. To that goal, we introduce a revolutionary approach in which TMS, fMRI, and EEG are applied simultaneously in healthy human volunteers to artificially unbalance the brain, and then study and control processes of rebalancing. Because we are one of the few groups worldwide that has accomplished this methodology, and that has the expertise to fully analyse the data it will yield, we are in a unique position to deliver both fundamental insights into brain plasticity, and derived new therapies. In brief, we will use TMS to (i) mimic spatial neglect in healthy volunteers while simultaneously monitoring the underlying neural network effects using fMRI/EEG, and to (ii) determine which exact brain reorganisation leads to an optimal behavioral recovery after injury. Importantly, we will use cutting-edge fMRI pattern recognition and machine learning algorithms to predict which concrete TMS treatment will specifically support this optimal functional reorganisation in the unbalanced brain. Finally, we will directly translate these fundamental findings into clinical practise and apply novel TMS protocols to rebalance the brain in patients suffering from parietal stroke.
Max ERC Funding
1 344 853 €
Duration
Start date: 2011-04-01, End date: 2016-03-31
Project acronym BRAINBELIEFS
Project Proving or improving yourself: longitudinal effects of ability beliefs on neural feedback processing and school outcomes
Researcher (PI) Nienke VAN ATTEVELDT
Host Institution (HI) STICHTING VU
Call Details Starting Grant (StG), SH4, ERC-2016-STG
Summary To successfully complete secondary education, persistent learning behavior is essential. Why are some adolescents more resilient to setbacks at school than others? In addition to actual ability, students’ implicit beliefs about the nature of their abilities have major impact on their motivation and achievements. Ability beliefs range from viewing abilities as “entities” that cannot be improved much by effort (entity beliefs), to believing that they are incremental with effort and time (incremental beliefs). Importantly, ability beliefs shape which goals a student pursues at school; proving themselves (performance goals) or improving themselves (learning goals). The central aims of the proposal are to unravel 1) the underlying processing mechanisms of how beliefs and goals shape resilience to setbacks at school and 2) how to influence these mechanisms to stimulate persistent learning behavior.
Functional brain research, including my own, has revealed the profound top-down influence of goals on selective information processing. Goals may thus determine which learning-related information is attended. Project 1 jointly investigates the essential psychological and neurobiological processes to unravel the longitudinal effects of beliefs and goals on how the brain prioritizes information during learning, and how this relates to school outcomes. Project 2 reveals how to influence this interplay with the aim to long-lastingly stimulate persistent learning behavior. I will move beyond existing approaches by introducing a novel intervention in which students experience their own learning-related brain activity and its malleability.
The results will demonstrate how ability beliefs and goals shape functional brain development and school outcomes during adolescence, and how we can optimally stimulate this interplay. The research has high scientific impact as it bridges multiple disciplines and thereby provides a strong impulse to the emerging field of educational neuroscience.
Summary
To successfully complete secondary education, persistent learning behavior is essential. Why are some adolescents more resilient to setbacks at school than others? In addition to actual ability, students’ implicit beliefs about the nature of their abilities have major impact on their motivation and achievements. Ability beliefs range from viewing abilities as “entities” that cannot be improved much by effort (entity beliefs), to believing that they are incremental with effort and time (incremental beliefs). Importantly, ability beliefs shape which goals a student pursues at school; proving themselves (performance goals) or improving themselves (learning goals). The central aims of the proposal are to unravel 1) the underlying processing mechanisms of how beliefs and goals shape resilience to setbacks at school and 2) how to influence these mechanisms to stimulate persistent learning behavior.
Functional brain research, including my own, has revealed the profound top-down influence of goals on selective information processing. Goals may thus determine which learning-related information is attended. Project 1 jointly investigates the essential psychological and neurobiological processes to unravel the longitudinal effects of beliefs and goals on how the brain prioritizes information during learning, and how this relates to school outcomes. Project 2 reveals how to influence this interplay with the aim to long-lastingly stimulate persistent learning behavior. I will move beyond existing approaches by introducing a novel intervention in which students experience their own learning-related brain activity and its malleability.
The results will demonstrate how ability beliefs and goals shape functional brain development and school outcomes during adolescence, and how we can optimally stimulate this interplay. The research has high scientific impact as it bridges multiple disciplines and thereby provides a strong impulse to the emerging field of educational neuroscience.
Max ERC Funding
1 597 291 €
Duration
Start date: 2017-03-01, End date: 2022-02-28
Project acronym BRAINDEVELOPMENT
Project How brain development underlies advances in cognition and emotion in childhood and adolescence
Researcher (PI) Eveline Adriana Maria Crone
Host Institution (HI) UNIVERSITEIT LEIDEN
Call Details Starting Grant (StG), SH4, ERC-2010-StG_20091209
Summary Thanks to the recent advances in mapping brain activation during task performance using functional Magnetic Resonance Imaging (i.e., studying the brain in action), it is now possible to study one of the oldest questions in psychology: how the development of neural circuitry underlies the development of cognition and emotion. The ‘Storm and Stress’ of adolescence, a period during which adolescents develop cognitively with great speed but are also risk-takers and sensitive to opinions of their peer group, has puzzled scientists for centuries. New technologies of brain mapping have the potential to shed new light on the mystery of adolescence. The approach proposed here concerns the investigation of brain regions which underlie developmental changes in cognitive, emotional and social-emotional functions over the course of child and adolescent development.
For this purpose I will measure functional brain development longitudinally across the age range 8-20 years by using a combined cross-sectional longitudinal design including 240 participants. Participants will take part in two testing sessions over a four-year-period in order to track the within-subject time courses of functional brain development for cognitive, emotional and social-emotional functions and to understand how these functions develop relative to each other in the same individuals, using multilevel models for change. The cross-sectional longitudinal assessment of cognitive, emotional and social-emotional functional brain development in relation to brain structure and hormone levels is unique in the international field and has the potential to provide new explanations for old questions. The application of brain mapping combined with multilevel models for change is original, and allows for the examination of developmental trajectories rather than age comparisons. An integrative mapping (i.e., combined with task performance and with biological markers) of functional brain development is important not only for theory development, but also for understanding how children learn new tasks and participate in a complex social world, and eventually to tailor educational programs to the needs of children.
Summary
Thanks to the recent advances in mapping brain activation during task performance using functional Magnetic Resonance Imaging (i.e., studying the brain in action), it is now possible to study one of the oldest questions in psychology: how the development of neural circuitry underlies the development of cognition and emotion. The ‘Storm and Stress’ of adolescence, a period during which adolescents develop cognitively with great speed but are also risk-takers and sensitive to opinions of their peer group, has puzzled scientists for centuries. New technologies of brain mapping have the potential to shed new light on the mystery of adolescence. The approach proposed here concerns the investigation of brain regions which underlie developmental changes in cognitive, emotional and social-emotional functions over the course of child and adolescent development.
For this purpose I will measure functional brain development longitudinally across the age range 8-20 years by using a combined cross-sectional longitudinal design including 240 participants. Participants will take part in two testing sessions over a four-year-period in order to track the within-subject time courses of functional brain development for cognitive, emotional and social-emotional functions and to understand how these functions develop relative to each other in the same individuals, using multilevel models for change. The cross-sectional longitudinal assessment of cognitive, emotional and social-emotional functional brain development in relation to brain structure and hormone levels is unique in the international field and has the potential to provide new explanations for old questions. The application of brain mapping combined with multilevel models for change is original, and allows for the examination of developmental trajectories rather than age comparisons. An integrative mapping (i.e., combined with task performance and with biological markers) of functional brain development is important not only for theory development, but also for understanding how children learn new tasks and participate in a complex social world, and eventually to tailor educational programs to the needs of children.
Max ERC Funding
1 500 000 €
Duration
Start date: 2011-02-01, End date: 2016-01-31
Project acronym CAJS
Project The Christian Appropriation of the Jewish Scriptures: Allegory, Pauline Exegesis, and the Negotiation of Religious Identities
Researcher (PI) Hagit Amirav
Host Institution (HI) STICHTING VU
Call Details Starting Grant (StG), SH4, ERC-2007-StG
Summary This project focuses on the appropriation of the Old Testament by early Christian interpreters of the Bible. A historical approach, not commonly adopted in the study of biblical interpretation, will enable us to study how this process contributed to the formation of distinctive Christian identities within the multicultural society of the late Roman principate and early Byzantine rule. The exegetes of this period were to a great extent responsible for the creation of a distinctive, sophisticated, and uncompromising discourse—a ‘totalising Christian discourse’, which determines Christian identities up to this day. In two projects, carried out by three researchers, we will make cross sections of the relevant material. It was allegorizing interpretation that enabled exegetes belonging to the so-called School of Alexandria to recognize Christ everywhere in the Old Testament, and thus to appropriate it and make it useful to the Church. Thus the Song of Songs was no longer considered an earthly love song, but was said to describe Christ’s love for the Church. Exegetes associated with the School of Antioch opposed to this kind of approach. They are often described as literalists. The traditional understanding of the distinctions between the two schools needs to be broadened and corrected by a picture of the actual practice of their hermeneutics. In my view the Antiochene opposition was brought about by the fact that pagan and ‘heretic’ critics did not accept the Alexandrian use of allegory. My innovative hypothesis is related to the central role played by the letters of the apostle Paul in the Antiochene reaction against Alexandria. For the Antiochenes, the use of Paul became an alternative means to bridge the gap between the two Testaments. Instead of a book in which every jot and tittle referred to Christ through allegory, the Antiochenes came to view the Old Testament as an amalgamation of moral lessons that agreed with Paul's teaching.
Summary
This project focuses on the appropriation of the Old Testament by early Christian interpreters of the Bible. A historical approach, not commonly adopted in the study of biblical interpretation, will enable us to study how this process contributed to the formation of distinctive Christian identities within the multicultural society of the late Roman principate and early Byzantine rule. The exegetes of this period were to a great extent responsible for the creation of a distinctive, sophisticated, and uncompromising discourse—a ‘totalising Christian discourse’, which determines Christian identities up to this day. In two projects, carried out by three researchers, we will make cross sections of the relevant material. It was allegorizing interpretation that enabled exegetes belonging to the so-called School of Alexandria to recognize Christ everywhere in the Old Testament, and thus to appropriate it and make it useful to the Church. Thus the Song of Songs was no longer considered an earthly love song, but was said to describe Christ’s love for the Church. Exegetes associated with the School of Antioch opposed to this kind of approach. They are often described as literalists. The traditional understanding of the distinctions between the two schools needs to be broadened and corrected by a picture of the actual practice of their hermeneutics. In my view the Antiochene opposition was brought about by the fact that pagan and ‘heretic’ critics did not accept the Alexandrian use of allegory. My innovative hypothesis is related to the central role played by the letters of the apostle Paul in the Antiochene reaction against Alexandria. For the Antiochenes, the use of Paul became an alternative means to bridge the gap between the two Testaments. Instead of a book in which every jot and tittle referred to Christ through allegory, the Antiochenes came to view the Old Testament as an amalgamation of moral lessons that agreed with Paul's teaching.
Max ERC Funding
655 309 €
Duration
Start date: 2008-09-01, End date: 2013-12-31
Project acronym CALMIRS
Project RNA-based regulation of signal transduction –
Regulation of calcineurin/NFAT signaling by microRNA-based mechanisms
Researcher (PI) Leon Johannes De Windt
Host Institution (HI) UNIVERSITEIT MAASTRICHT
Call Details Starting Grant (StG), LS4, ERC-2012-StG_20111109
Summary "Heart failure is a serious clinical disorder that represents the primary cause of hospitalization and death in Europe and the United States. There is a dire need for new paradigms and therapeutic approaches for treatment of this devastating disease. The heart responds to mechanical load and various extracellular stimuli by hypertrophic growth and sustained pathological hypertrophy is a major clinical predictor of heart failure. A variety of stress-responsive signaling pathways promote cardiac hypertrophy, but the precise mechanisms that link these pathways to cardiac disease are only beginning to be unveiled. Signal transduction is traditionally concentrated on the protein coding part of the genome, but it is now appreciated that the protein coding part of the genome only constitutes 1.5% of the genome. RNA based mechanisms may provide a more complete understanding of the fundamentals of cellular signaling. As a proof-of-principle, we focus on a principal hypertrophic signaling cascade, cardiac calcineurin/NFAT signaling. Here we will establish that microRNAs are intimately interwoven with this signaling cascade, influence signaling strength by unexpected upstream mechanisms. Secondly, we will firmly establish that microRNA target genes critically contribute to genesis of heart failure. Third, the surprising stability of circulating microRNAs has opened the possibility to develop the next generation of biomarkers and provide unexpected mechanisms how genetic information is transported between cells in multicellular organs and fascilitate inter-cellular communication. Finally, microRNA-based therapeutic silencing is remarkably powerful and offers opportunities to specifically intervene in pathological signaling as the next generation heart failure therapeutics. CALMIRS aims to mine the wealth of these RNA mechanisms to enable the development of next generation RNA based signal transduction biology, with surprising new diagnostic and therapeutic opportunities."
Summary
"Heart failure is a serious clinical disorder that represents the primary cause of hospitalization and death in Europe and the United States. There is a dire need for new paradigms and therapeutic approaches for treatment of this devastating disease. The heart responds to mechanical load and various extracellular stimuli by hypertrophic growth and sustained pathological hypertrophy is a major clinical predictor of heart failure. A variety of stress-responsive signaling pathways promote cardiac hypertrophy, but the precise mechanisms that link these pathways to cardiac disease are only beginning to be unveiled. Signal transduction is traditionally concentrated on the protein coding part of the genome, but it is now appreciated that the protein coding part of the genome only constitutes 1.5% of the genome. RNA based mechanisms may provide a more complete understanding of the fundamentals of cellular signaling. As a proof-of-principle, we focus on a principal hypertrophic signaling cascade, cardiac calcineurin/NFAT signaling. Here we will establish that microRNAs are intimately interwoven with this signaling cascade, influence signaling strength by unexpected upstream mechanisms. Secondly, we will firmly establish that microRNA target genes critically contribute to genesis of heart failure. Third, the surprising stability of circulating microRNAs has opened the possibility to develop the next generation of biomarkers and provide unexpected mechanisms how genetic information is transported between cells in multicellular organs and fascilitate inter-cellular communication. Finally, microRNA-based therapeutic silencing is remarkably powerful and offers opportunities to specifically intervene in pathological signaling as the next generation heart failure therapeutics. CALMIRS aims to mine the wealth of these RNA mechanisms to enable the development of next generation RNA based signal transduction biology, with surprising new diagnostic and therapeutic opportunities."
Max ERC Funding
1 499 528 €
Duration
Start date: 2013-02-01, End date: 2018-01-31