Project acronym COLLMOT
Project Complex structure and dynamics of collective motion
Researcher (PI) Tamás Vicsek
Host Institution (HI) EOTVOS LORAND TUDOMANYEGYETEM
Call Details Advanced Grant (AdG), PE3, ERC-2008-AdG
Summary Collective behaviour is a widespread phenomenon in nature and technology making it a very important subject to study in various contexts. The main goal we intend to achieve in our multidisciplinary research is the identification and documentation of new unifying principles describing the essential aspects of collective motion, being one of the most relevant and spectacular manifestations of collective behaviour. We shall carry out novel type of experiments, design models that are both simple and realistic enough to reproduce the observations and develop concepts for a better interpretation of the complexity of systems consisting of many organisms and such non-living objects as interacting robots. We plan to study systems ranging from cultures of migrating tissue cells through flocks of birds to collectively moving devices. The interrelation of these systems will be considered in order to deepen the understanding of the main patterns of group motion in both living and non-living systems by learning about the similar phenomena in the two domains of nature. Thus, we plan to understand the essential ingredients of flocking of birds by building collectively moving unmanned aerial vehicles while, in turn, high resolution spatiotemporal GPS data of pigeon flocks will be used to make helpful conclusions for the best designs for swarms of robots. In particular, we shall construct and build a set of vehicles that will be capable, for the first time, to exhibit flocking behaviour in the three-dimensional space. The methods we shall adopt will range from approaches used in statistical physics and network theory to various new techniques in cell biology and collective robotics. All this will be based on numerous prior results (both ours and others) published in leading interdisciplinary journals. The planned research will have the potential of leading to ground breaking results with significant implications in various fields of science and technology.
Summary
Collective behaviour is a widespread phenomenon in nature and technology making it a very important subject to study in various contexts. The main goal we intend to achieve in our multidisciplinary research is the identification and documentation of new unifying principles describing the essential aspects of collective motion, being one of the most relevant and spectacular manifestations of collective behaviour. We shall carry out novel type of experiments, design models that are both simple and realistic enough to reproduce the observations and develop concepts for a better interpretation of the complexity of systems consisting of many organisms and such non-living objects as interacting robots. We plan to study systems ranging from cultures of migrating tissue cells through flocks of birds to collectively moving devices. The interrelation of these systems will be considered in order to deepen the understanding of the main patterns of group motion in both living and non-living systems by learning about the similar phenomena in the two domains of nature. Thus, we plan to understand the essential ingredients of flocking of birds by building collectively moving unmanned aerial vehicles while, in turn, high resolution spatiotemporal GPS data of pigeon flocks will be used to make helpful conclusions for the best designs for swarms of robots. In particular, we shall construct and build a set of vehicles that will be capable, for the first time, to exhibit flocking behaviour in the three-dimensional space. The methods we shall adopt will range from approaches used in statistical physics and network theory to various new techniques in cell biology and collective robotics. All this will be based on numerous prior results (both ours and others) published in leading interdisciplinary journals. The planned research will have the potential of leading to ground breaking results with significant implications in various fields of science and technology.
Max ERC Funding
1 248 000 €
Duration
Start date: 2009-03-01, End date: 2015-02-28
Project acronym DISCONV
Project DISCRETE AND CONVEX GEOMETRY: CHALLENGES, METHODS, APPLICATIONS
Researcher (PI) Imre Barany
Host Institution (HI) RENYI ALFRED MATEMATIKAI KUTATOINTEZET
Call Details Advanced Grant (AdG), PE1, ERC-2010-AdG_20100224
Summary Title: Discrete and convex geometry: challenges, methods, applications
Abstract: Research in discrete and convex geometry, using tools from combinatorics, algebraic
topology, probability theory, number theory, and algebra, with applications in theoretical
computer science, integer programming, and operations research. Algorithmic aspects are
emphasized and often serve as motivation or simply dictate the questions. The proposed
problems can be grouped into three main areas: (1) Geometric transversal, selection, and
incidence problems, including algorithmic complexity of Tverberg's theorem, weak
epsilon-nets, the k-set problem, and algebraic approaches to the Erdos unit distance problem.
(2) Topological methods and questions, in particular topological Tverberg-type theorems,
algorithmic complexity of the existence of equivariant maps, mass partition problems, and the
generalized HeX lemma for the k-coloured d-dimensional grid. (3) Lattice polytopes and random
polytopes, including Arnold's question on the number of convex lattice polytopes, limit
shapes of lattice polytopes in dimension 3 and higher, comparison of random polytopes and
lattice polytopes, the integer convex hull and its randomized version.
Summary
Title: Discrete and convex geometry: challenges, methods, applications
Abstract: Research in discrete and convex geometry, using tools from combinatorics, algebraic
topology, probability theory, number theory, and algebra, with applications in theoretical
computer science, integer programming, and operations research. Algorithmic aspects are
emphasized and often serve as motivation or simply dictate the questions. The proposed
problems can be grouped into three main areas: (1) Geometric transversal, selection, and
incidence problems, including algorithmic complexity of Tverberg's theorem, weak
epsilon-nets, the k-set problem, and algebraic approaches to the Erdos unit distance problem.
(2) Topological methods and questions, in particular topological Tverberg-type theorems,
algorithmic complexity of the existence of equivariant maps, mass partition problems, and the
generalized HeX lemma for the k-coloured d-dimensional grid. (3) Lattice polytopes and random
polytopes, including Arnold's question on the number of convex lattice polytopes, limit
shapes of lattice polytopes in dimension 3 and higher, comparison of random polytopes and
lattice polytopes, the integer convex hull and its randomized version.
Max ERC Funding
1 298 012 €
Duration
Start date: 2011-04-01, End date: 2017-03-31
Project acronym DISCRETECONT
Project From discrete to contimuous: understanding discrete structures through continuous approximation
Researcher (PI) László Lovász
Host Institution (HI) EOTVOS LORAND TUDOMANYEGYETEM
Call Details Advanced Grant (AdG), PE1, ERC-2008-AdG
Summary Important methods and results in discrete mathematics arise from the interaction between discrete mathematics and ``continuous'' areas like analysis or geometry. Classical examples of this include topological methods, linear and semidefinite optimization generating functions and more. More recent areas stressing this connection are the theory of limit objects of growing sequences of finite structures (graphs, hypergraphs, sequences), differential equations on networks, geometric representations of graphs. Perhaps most promising is the study of limits of growing graph and hypergraph sequences. In resent work by the Proposer and his collaborators, this area has found highly nontrivial connections with extremal graph theory, the theory of property testing in computer science, to additive number theory, the theory of random graphs, and measure theory as well as geometric representations of graphs. This proposal's goal is to explore these interactions, with the participation of a number of researchers from different areas of mathematics.
Summary
Important methods and results in discrete mathematics arise from the interaction between discrete mathematics and ``continuous'' areas like analysis or geometry. Classical examples of this include topological methods, linear and semidefinite optimization generating functions and more. More recent areas stressing this connection are the theory of limit objects of growing sequences of finite structures (graphs, hypergraphs, sequences), differential equations on networks, geometric representations of graphs. Perhaps most promising is the study of limits of growing graph and hypergraph sequences. In resent work by the Proposer and his collaborators, this area has found highly nontrivial connections with extremal graph theory, the theory of property testing in computer science, to additive number theory, the theory of random graphs, and measure theory as well as geometric representations of graphs. This proposal's goal is to explore these interactions, with the participation of a number of researchers from different areas of mathematics.
Max ERC Funding
739 671 €
Duration
Start date: 2009-01-01, End date: 2014-06-30
Project acronym EAST-WEST
Project Vernacular religion on the boundary of Eastern and Western Christianity: continuity, changes and interactions
Researcher (PI) Zsoltné Csalog
Host Institution (HI) BOLCSESZETTUDOMANYI KUTATOKOZPONT
Call Details Advanced Grant (AdG), SH2, ERC-2012-ADG_20120411
Summary This interdisciplinary research project, relying on mutually complementary historical, anthropological and folklore investigations, will examine continuities and transformations in vernacular religion in the border-zone between Eastern and Western Christianity. The project will have three foci: 1) the role of the religious worldview and norms in past and present communities; 2) change and religious modernisation including the intertwining of the breaking up of the traditional worldview and the appearance of consumer-type attitudes of New Age religiosity; 3) the role of religion in identity formation and the emergence of religious pluralism and co-operation as well as of religious antagonism and conflict between different denominations and nationalities in the region. Members of the project will study these questions in Hungarian, Romanian, Serbian, Ukrainian and Croatian communities of mixed religion. Thematically the research will be organised around exploring symbolic exchange relationships (demonology and witchcraft) sacred communication (shrines, visions, miracles, saints) and healing using both historical sources and contemporary anthropological field work.
The project builds on two previous long-term historical/folkloristic research projects led by PI Éva Pócs and will expand and complement their findings through contemporary anthropological field research and continued archival work. Integrating the results of the current and earlier projects through an innovative electronic document collection, embedded in a geographical information system, will enhance the impact of both sets of materials.
The research will bring us closer to understanding a) inter-religious relationships between Catholic, Protestant and Orthodox believers, b) problems of national identity underlying religious antagonisms, and c) how religious and cultural border zones separate and unite, generate conflict and create mutual understanding, potentially promoting peaceful co-existence.
Summary
This interdisciplinary research project, relying on mutually complementary historical, anthropological and folklore investigations, will examine continuities and transformations in vernacular religion in the border-zone between Eastern and Western Christianity. The project will have three foci: 1) the role of the religious worldview and norms in past and present communities; 2) change and religious modernisation including the intertwining of the breaking up of the traditional worldview and the appearance of consumer-type attitudes of New Age religiosity; 3) the role of religion in identity formation and the emergence of religious pluralism and co-operation as well as of religious antagonism and conflict between different denominations and nationalities in the region. Members of the project will study these questions in Hungarian, Romanian, Serbian, Ukrainian and Croatian communities of mixed religion. Thematically the research will be organised around exploring symbolic exchange relationships (demonology and witchcraft) sacred communication (shrines, visions, miracles, saints) and healing using both historical sources and contemporary anthropological field work.
The project builds on two previous long-term historical/folkloristic research projects led by PI Éva Pócs and will expand and complement their findings through contemporary anthropological field research and continued archival work. Integrating the results of the current and earlier projects through an innovative electronic document collection, embedded in a geographical information system, will enhance the impact of both sets of materials.
The research will bring us closer to understanding a) inter-religious relationships between Catholic, Protestant and Orthodox believers, b) problems of national identity underlying religious antagonisms, and c) how religious and cultural border zones separate and unite, generate conflict and create mutual understanding, potentially promoting peaceful co-existence.
Max ERC Funding
2 079 485 €
Duration
Start date: 2013-09-01, End date: 2018-08-31
Project acronym ELITES08
Project Culturally Composite Elites, Regime Changes and Social Crises in Multi-Ethnic and Multi-Confessional Eastern Europe. (The Carpathian Basin and the Baltics in Comparison - cc. 1900-1950)
Researcher (PI) Gyozo István Karády
Host Institution (HI) KOZEP-EUROPAI EGYETEM
Call Details Advanced Grant (AdG), SH6, ERC-2008-AdG
Summary The project is multi-disciplinary by character. It focuses upon socio-historical processes of the transformation and 'circulation' of educated and ruling elites in several uniquely composite (both multi-ethnic and multi-confessional) East European regional or national societies, having experienced a number of radical changes of social and political regime as well as state souvereignty in the first half of the 20th century. The historical scope of the study extends from post-feudalism to communism. Societies involved comprise Hungary, Slovakia, Transylvania, Voivodina in the Carpathian Basin, Latvia and Estonia in the Baltics. The study draws upon sociological survey methods applied to historically successive elite brackets in form of exhaustive or quasi-exhaustive computerized prosopographical data banks, based on standardized individual biographies of elite members (as permitted by mostly archival sources to be exploited). The main targets would include secondary school graduates, students and graduates of higher education, the main intellectual professions (like doctors and lawyers.), the political power elites as well as 'reputational elites' - those cited in biographical dictionaries. The information fed into our data banks help to clarify thanks to various procedures of multi-variate statistical schemes the contrasting socio-cultural selection and recruitment of elite members, their educational path from primary to higher education, their professional career, intellectual creativity as well as socio-political standing and orientation. This is the first time that large region- or country-wide elite clusters are submitted to systematic socio-historical analyses, covering simultaneously all or most markets of activity and self-assertion of educated clusters in a vast international and comparative perspective related to culturally composite societal formations.
Summary
The project is multi-disciplinary by character. It focuses upon socio-historical processes of the transformation and 'circulation' of educated and ruling elites in several uniquely composite (both multi-ethnic and multi-confessional) East European regional or national societies, having experienced a number of radical changes of social and political regime as well as state souvereignty in the first half of the 20th century. The historical scope of the study extends from post-feudalism to communism. Societies involved comprise Hungary, Slovakia, Transylvania, Voivodina in the Carpathian Basin, Latvia and Estonia in the Baltics. The study draws upon sociological survey methods applied to historically successive elite brackets in form of exhaustive or quasi-exhaustive computerized prosopographical data banks, based on standardized individual biographies of elite members (as permitted by mostly archival sources to be exploited). The main targets would include secondary school graduates, students and graduates of higher education, the main intellectual professions (like doctors and lawyers.), the political power elites as well as 'reputational elites' - those cited in biographical dictionaries. The information fed into our data banks help to clarify thanks to various procedures of multi-variate statistical schemes the contrasting socio-cultural selection and recruitment of elite members, their educational path from primary to higher education, their professional career, intellectual creativity as well as socio-political standing and orientation. This is the first time that large region- or country-wide elite clusters are submitted to systematic socio-historical analyses, covering simultaneously all or most markets of activity and self-assertion of educated clusters in a vast international and comparative perspective related to culturally composite societal formations.
Max ERC Funding
771 628 €
Duration
Start date: 2009-01-01, End date: 2012-03-31
Project acronym FRONTHAL
Project Specificity of cortico-thalamic interactions and its role in frontal cortical functions
Researcher (PI) Laszlo ACSADY
Host Institution (HI) INSTITUTE OF EXPERIMENTAL MEDICINE - HUNGARIAN ACADEMY OF SCIENCES
Call Details Advanced Grant (AdG), LS5, ERC-2016-ADG
Summary Frontal cortical areas are responsible for a wide range of executive and cognitive functions. Frontal cortices communicate with the thalamus via bidirectional pathways and these connections are indispensable for frontal cortical operations. Still, we have very little information about the specificity of connections, synaptic interactions and plasticity between frontal cortex and thalamus and the roles of these interactions in frontal cortical functions.
In the present proposal, we will test the hypothesis that frontal cortical areas developed a highly specialized connectivity pattern with the thalamus. This supports unique interactions between the cortex and the thalamus according to the specific requirements of frontal cortical activity, including experience-dependent plastic changes.
The project will use cell type-specific viral tracing in mice and 3D electron microscopic reconstructions in mice and humans to identify circuit motifs that are evolutionarily conserved, yet, still specific to fronto-thalamic pathways. The physiological approach will employ in vivo optogenetics combined with intra-, juxta- and extracellular recordings. We will perform behavioral experiments by bidirectional modulation of well-defined elements in the network, in learning paradigms, which depend on the integrity of frontal cortex.
The project is the first systematic approach which aims to understand the nature of interaction between the frontal cortex and the thalamus. It will not only fill the tremendous gap in our knowledge regarding these pathways but will help us elucidate the functional organization of non-sensory thalamus in general.
Frontal cortices are involved in a wide range of major neurological disorders (e.g. Parkinson’s disease, epilepsy, schizophrenia, chronic pain) which affect executive functions and involve fronto-thalamic pathways. We believe that understanding fronto-thalamic interactions will lead to fundamentally novel insight into the nature of these diseases.
Summary
Frontal cortical areas are responsible for a wide range of executive and cognitive functions. Frontal cortices communicate with the thalamus via bidirectional pathways and these connections are indispensable for frontal cortical operations. Still, we have very little information about the specificity of connections, synaptic interactions and plasticity between frontal cortex and thalamus and the roles of these interactions in frontal cortical functions.
In the present proposal, we will test the hypothesis that frontal cortical areas developed a highly specialized connectivity pattern with the thalamus. This supports unique interactions between the cortex and the thalamus according to the specific requirements of frontal cortical activity, including experience-dependent plastic changes.
The project will use cell type-specific viral tracing in mice and 3D electron microscopic reconstructions in mice and humans to identify circuit motifs that are evolutionarily conserved, yet, still specific to fronto-thalamic pathways. The physiological approach will employ in vivo optogenetics combined with intra-, juxta- and extracellular recordings. We will perform behavioral experiments by bidirectional modulation of well-defined elements in the network, in learning paradigms, which depend on the integrity of frontal cortex.
The project is the first systematic approach which aims to understand the nature of interaction between the frontal cortex and the thalamus. It will not only fill the tremendous gap in our knowledge regarding these pathways but will help us elucidate the functional organization of non-sensory thalamus in general.
Frontal cortices are involved in a wide range of major neurological disorders (e.g. Parkinson’s disease, epilepsy, schizophrenia, chronic pain) which affect executive functions and involve fronto-thalamic pathways. We believe that understanding fronto-thalamic interactions will lead to fundamentally novel insight into the nature of these diseases.
Max ERC Funding
1 597 575 €
Duration
Start date: 2017-09-01, End date: 2022-08-31
Project acronym FunctionalProteomics
Project Proteomic fingerprinting of functionally characterized single synapses
Researcher (PI) Zoltan NUSSER
Host Institution (HI) INSTITUTE OF EXPERIMENTAL MEDICINE - HUNGARIAN ACADEMY OF SCIENCES
Call Details Advanced Grant (AdG), LS5, ERC-2017-ADG
Summary Our astonishing cognitive abilities are the consequence of complex connectivity within our neuronal networks and the large functional diversity of excitable nerve cells and their synapses. Investigations over the past half a century revealed dramatic diversity in shape, size and functional properties among synapses established by distinct cell types in different brain regions and demonstrated that the functional differences are partly due to different molecular mechanisms. However, synaptic diversity is also observed among synapses established by molecularly and morphologically uniform presynaptic cells on molecularly and morphologically uniform postsynaptic cells. Our hypothesis is that quantitative molecular differences underlie the functional diversity of such synapses. We will focus on hippocampal CA1 pyramidal cell (PC) to mGluR1α+ O-LM cell synapses, which show remarkable functional and molecular heterogeneity. In vitro multiple cell patch-clamp recordings followed by quantal analysis will be performed to quantify well-defined biophysical properties of these synapses. The molecular composition of the functionally characterized single synapses will be determined following the development of a novel postembedding immunolocalization method. Correlations between the molecular content and functional properties will be established and genetic up- and downregulation of individual synaptic proteins will be conducted to reveal causal relationships. Finally, correlations of the activity history and the functional properties of the synapses will be established by performing in vivo two-photon Ca2+ imaging in head-fixed behaving animals followed by in vitro functional characterization of their synapses. Our results will reveal quantitative molecular fingerprints of functional properties, allowing us to render dynamic behaviour to billions of synapses when the connectome of the hippocampal circuit is created using array tomography.
Summary
Our astonishing cognitive abilities are the consequence of complex connectivity within our neuronal networks and the large functional diversity of excitable nerve cells and their synapses. Investigations over the past half a century revealed dramatic diversity in shape, size and functional properties among synapses established by distinct cell types in different brain regions and demonstrated that the functional differences are partly due to different molecular mechanisms. However, synaptic diversity is also observed among synapses established by molecularly and morphologically uniform presynaptic cells on molecularly and morphologically uniform postsynaptic cells. Our hypothesis is that quantitative molecular differences underlie the functional diversity of such synapses. We will focus on hippocampal CA1 pyramidal cell (PC) to mGluR1α+ O-LM cell synapses, which show remarkable functional and molecular heterogeneity. In vitro multiple cell patch-clamp recordings followed by quantal analysis will be performed to quantify well-defined biophysical properties of these synapses. The molecular composition of the functionally characterized single synapses will be determined following the development of a novel postembedding immunolocalization method. Correlations between the molecular content and functional properties will be established and genetic up- and downregulation of individual synaptic proteins will be conducted to reveal causal relationships. Finally, correlations of the activity history and the functional properties of the synapses will be established by performing in vivo two-photon Ca2+ imaging in head-fixed behaving animals followed by in vitro functional characterization of their synapses. Our results will reveal quantitative molecular fingerprints of functional properties, allowing us to render dynamic behaviour to billions of synapses when the connectome of the hippocampal circuit is created using array tomography.
Max ERC Funding
2 498 750 €
Duration
Start date: 2018-10-01, End date: 2023-09-30
Project acronym GROGandGIN
Project Growth in Groups and Graph Isomorphism Now
Researcher (PI) Laszlo Pyber
Host Institution (HI) RENYI ALFRED MATEMATIKAI KUTATOINTEZET
Call Details Advanced Grant (AdG), PE1, ERC-2016-ADG
Summary "In recent years there has been spectacular progress in studying growth in groups. A central result in this new area, obtained by Pyber-Szabo' (with a similar result proved by Breuillard-Green-Tao), shows that powers of generating subsets of finite simple groups of ""bounded dimension"" grow fast. Extending this Product Theorem Szabo' and the PI also proved a weaker version of a conjecture of Helfgott-Lindenstrauss. The Product Theorem has deep consequences in the study of groups, number theory and random walks. A central open question of the area is to remove the dependence on dimension in our Product Theorem. The PI formulated a new Conjecture, as a step forward. The way to further progress is via combining techniques from asymptotic group theory and probability theory. It is from this perspective that the current GROGandGIN proposal addresses issues concerning random walks. We examine how recent probabilistic arguments for random walks in the symmetric group may be transferred to matrix groups. While the first results in the subject of growth concern matrix groups we see an evolving theory of growth in permutation groups. This relies on earlier work of Babai and the PI which aims at finding proofs which do not use the Classification of Finite Simple Groups (CFSG). Similarly, Babai's famous Quasipolynomial Graph Isomorphism Algorithm builds on ideas from CFSG-free proofs due to him. The PI has recently removed CFSG from the analysis of Babai's algorithm. Our method goes ""halfway"" towards removing CFSG from proofs of growth results for permutation groups, currently a major open problem. The GROGandGIN initiative plans to improve various other parts of Babai's paper, working with several people who look at it from different angles, with an eye towards obtaining a Polynomial Graph Isomorphism algorithm. The GROGandGIN team will also study growth in Lie groups since the theory of random walks in Lie groups has been revitalised using analogues of our Product Theorem."
Summary
"In recent years there has been spectacular progress in studying growth in groups. A central result in this new area, obtained by Pyber-Szabo' (with a similar result proved by Breuillard-Green-Tao), shows that powers of generating subsets of finite simple groups of ""bounded dimension"" grow fast. Extending this Product Theorem Szabo' and the PI also proved a weaker version of a conjecture of Helfgott-Lindenstrauss. The Product Theorem has deep consequences in the study of groups, number theory and random walks. A central open question of the area is to remove the dependence on dimension in our Product Theorem. The PI formulated a new Conjecture, as a step forward. The way to further progress is via combining techniques from asymptotic group theory and probability theory. It is from this perspective that the current GROGandGIN proposal addresses issues concerning random walks. We examine how recent probabilistic arguments for random walks in the symmetric group may be transferred to matrix groups. While the first results in the subject of growth concern matrix groups we see an evolving theory of growth in permutation groups. This relies on earlier work of Babai and the PI which aims at finding proofs which do not use the Classification of Finite Simple Groups (CFSG). Similarly, Babai's famous Quasipolynomial Graph Isomorphism Algorithm builds on ideas from CFSG-free proofs due to him. The PI has recently removed CFSG from the analysis of Babai's algorithm. Our method goes ""halfway"" towards removing CFSG from proofs of growth results for permutation groups, currently a major open problem. The GROGandGIN initiative plans to improve various other parts of Babai's paper, working with several people who look at it from different angles, with an eye towards obtaining a Polynomial Graph Isomorphism algorithm. The GROGandGIN team will also study growth in Lie groups since the theory of random walks in Lie groups has been revitalised using analogues of our Product Theorem."
Max ERC Funding
1 965 340 €
Duration
Start date: 2017-08-01, End date: 2022-07-31
Project acronym INTERIMPACT
Project Impact of identified interneurons on cellular network mechanisms in the human and rodent neocortex
Researcher (PI) Gábor Tamás
Host Institution (HI) SZEGEDI TUDOMANYEGYETEM
Call Details Advanced Grant (AdG), LS5, ERC-2010-AdG_20100317
Summary This application addresses mechanisms linking the activity of single neurons with network events by defining the function of identified cell types in the cerebral cortex. The key hypotheses emerged from our experiments and propose that neurogliaform cells and axo-axonic cells achieve their function in the cortex through extreme forms of unspecificity and specificity, respectively. The project capitalizes on our discovery that neurogliaform cells reach GABAA and GABAB receptors on target cells through unitary volume transmission going beyond the classical theory which states that single cortical neurons act in or around synaptic junctions. We propose that the spatial unspecificity of neurotransmitter action leads to unprecedented functional capabilities for a single neuron simultaneously acting on neuronal, glial and vascular components of the surrounding area allowing neurogliaform cells to synchronize metabolic demand and supply in microcircuits. In contrast, axo-axonic cells represent extreme spatial specificity in the brain: terminals of axo-axonic cells exclusively target the axon initial segment of pyramidal neurons. Axo-axonic cells were considered as the most potent inhibitory neurons of the cortex. However, our experiments suggested that axo-axonic cells can be the most powerful excitatory neurons known to date by triggering complex network events. Our unprecedented recordings in the human cortex show that axo-axonic cells are crucial in activating functional assemblies which were implicated in higher order cognitive representations. We aim to define interactions between active cortical networks and axo-axonic cell triggered assemblies with an emphasis on mechanisms modulated by neurogliaform cells and commonly prescribed drugs.
Summary
This application addresses mechanisms linking the activity of single neurons with network events by defining the function of identified cell types in the cerebral cortex. The key hypotheses emerged from our experiments and propose that neurogliaform cells and axo-axonic cells achieve their function in the cortex through extreme forms of unspecificity and specificity, respectively. The project capitalizes on our discovery that neurogliaform cells reach GABAA and GABAB receptors on target cells through unitary volume transmission going beyond the classical theory which states that single cortical neurons act in or around synaptic junctions. We propose that the spatial unspecificity of neurotransmitter action leads to unprecedented functional capabilities for a single neuron simultaneously acting on neuronal, glial and vascular components of the surrounding area allowing neurogliaform cells to synchronize metabolic demand and supply in microcircuits. In contrast, axo-axonic cells represent extreme spatial specificity in the brain: terminals of axo-axonic cells exclusively target the axon initial segment of pyramidal neurons. Axo-axonic cells were considered as the most potent inhibitory neurons of the cortex. However, our experiments suggested that axo-axonic cells can be the most powerful excitatory neurons known to date by triggering complex network events. Our unprecedented recordings in the human cortex show that axo-axonic cells are crucial in activating functional assemblies which were implicated in higher order cognitive representations. We aim to define interactions between active cortical networks and axo-axonic cell triggered assemblies with an emphasis on mechanisms modulated by neurogliaform cells and commonly prescribed drugs.
Max ERC Funding
2 391 695 €
Duration
Start date: 2011-06-01, End date: 2017-05-31
Project acronym LTDBud
Project Low Dimensional Topology in Budapest
Researcher (PI) Andras Istvan Stipsicz
Host Institution (HI) RENYI ALFRED MATEMATIKAI KUTATOINTEZET
Call Details Advanced Grant (AdG), PE1, ERC-2011-ADG_20110209
Summary "Heegaard Floer theory. In this project (in collaboration with P. Ozsváth and Z. Szabó) we plan to extend our earlier results computing various versions of Heegaard Floer homologies purely combinatorially. We also plan to find combinatorial definitions of these invariants (as graded groups). Such results will potentially lead to a combinatorial description of 4-dimensional Heegaard Floer (mixed) invariants, conjecturally equivalent to Seiberg-Witten invariants of smooth 4-manifolds. In particular, we hope to find a combinatorial proof of Donaldson’s diagonalizability theorem, and find relations between the Heegaard Floer and the fundamental groups of a 3-manifold.
Contact topology. Using Heegaard Floer theory and contact surgery, a systematic study of existence of tight contact structures on 3-manifolds is planned. Similar techniques also apply in studying Legendrian and transverse knots in contact 3-manifolds. In particular, the verification of the existence of tight structures on 3-manifolds given by surgery on a knot (with high enough framing) in the 3-sphere is proposed. Using the Legendrian invariant of knots, Legendrian and transverse simplicity can be conveniently studied. The ideas detailed in this part are planned to be carried out partly in collaboration with Paolo Lisca, Vera Vértesi and Hansjörg Geiges.
Exotic 4-manifolds. Extending our previous results, we plan to investigate the existence of exotic smooth structures on 4-manifolds with small Euler characteristics, such as the complex projective plane CP2, its blow-up CP2#CP2-bar, the product of two complex projective lines CP1×CP1 and ultimately the 4-dimensional sphere S4. We plan to investigate the effect of the Gluck transformation. Possible extensions of the rational blow down procedure (successful in producing exotic structures) will be also studied. We plan collaborations with Zoltán Szabó, Daniel Nash and Mohan Bhupal in these questions."
Summary
"Heegaard Floer theory. In this project (in collaboration with P. Ozsváth and Z. Szabó) we plan to extend our earlier results computing various versions of Heegaard Floer homologies purely combinatorially. We also plan to find combinatorial definitions of these invariants (as graded groups). Such results will potentially lead to a combinatorial description of 4-dimensional Heegaard Floer (mixed) invariants, conjecturally equivalent to Seiberg-Witten invariants of smooth 4-manifolds. In particular, we hope to find a combinatorial proof of Donaldson’s diagonalizability theorem, and find relations between the Heegaard Floer and the fundamental groups of a 3-manifold.
Contact topology. Using Heegaard Floer theory and contact surgery, a systematic study of existence of tight contact structures on 3-manifolds is planned. Similar techniques also apply in studying Legendrian and transverse knots in contact 3-manifolds. In particular, the verification of the existence of tight structures on 3-manifolds given by surgery on a knot (with high enough framing) in the 3-sphere is proposed. Using the Legendrian invariant of knots, Legendrian and transverse simplicity can be conveniently studied. The ideas detailed in this part are planned to be carried out partly in collaboration with Paolo Lisca, Vera Vértesi and Hansjörg Geiges.
Exotic 4-manifolds. Extending our previous results, we plan to investigate the existence of exotic smooth structures on 4-manifolds with small Euler characteristics, such as the complex projective plane CP2, its blow-up CP2#CP2-bar, the product of two complex projective lines CP1×CP1 and ultimately the 4-dimensional sphere S4. We plan to investigate the effect of the Gluck transformation. Possible extensions of the rational blow down procedure (successful in producing exotic structures) will be also studied. We plan collaborations with Zoltán Szabó, Daniel Nash and Mohan Bhupal in these questions."
Max ERC Funding
1 208 980 €
Duration
Start date: 2012-04-01, End date: 2017-03-31