Project acronym BIRTH
Project Births, mothers and babies: prehistoric fertility in the Balkans between 10000 – 5000 BC
Researcher (PI) Sofija Stefanovic
Host Institution (HI) BIOSENSE INSTITUTE - RESEARCH AND DEVELOPMENT INSTITUTE FOR INFORMATION TECHNOLOGIES IN BIOSYSTEMS
Call Details Starting Grant (StG), SH6, ERC-2014-STG
Summary The BIRTH project will investigate the key biological and cultural mechanisms affecting fertility rates resulting the Neolithic Demogaphic Transition, the major demographic shift in human evolution. We integrate skeletal markers with micro-nutritional and macro-scaled cultural effects on fertility rates during the Early-Middle Holocene (10000-5000 BC) in the Central Balkans. Human, animal and plant remains, will be analysed using methods from bioarchaeological, forensic, chemical sciences in order to: 1) Investigate variability in the pattern of birth rates (number of pregnancies, interval(s) between them and the duration of the reproductive period) through histological analysis of irregularities in tooth cementum of women; 2) Determine paleoobstetric and neonatal body characteristics, health status and nutrition through analysis of skeletal remains; 3) Determine micronutritional changes during the Early-Middle Holocene through trace element (Zn, Ca and Fe) analysis; 4) Investigate the micro and macronutritional value of prehistoric foodstuffs, through an analysis of animal and plant remains and to compare the nutritional intake in relation to health and fertility; 5) Establish a chronology of the NDT in the Balkans by summed radiocarbon probability distributions; 6) Explore the possible role of culture in driving fertility increases, through analysis of community attitudes to birthing trough investigation of neonate graves and artifact connected to the birthing process. Given that the issues of health and fertility are of utmost importance in the present as they were in the past, the BIRTH project offers new understanding of biocultural mechanisms which led to fertility increase and novel approaches to ancient skeletal heritage, and emphasizes their great potential for modern humanity.
Summary
The BIRTH project will investigate the key biological and cultural mechanisms affecting fertility rates resulting the Neolithic Demogaphic Transition, the major demographic shift in human evolution. We integrate skeletal markers with micro-nutritional and macro-scaled cultural effects on fertility rates during the Early-Middle Holocene (10000-5000 BC) in the Central Balkans. Human, animal and plant remains, will be analysed using methods from bioarchaeological, forensic, chemical sciences in order to: 1) Investigate variability in the pattern of birth rates (number of pregnancies, interval(s) between them and the duration of the reproductive period) through histological analysis of irregularities in tooth cementum of women; 2) Determine paleoobstetric and neonatal body characteristics, health status and nutrition through analysis of skeletal remains; 3) Determine micronutritional changes during the Early-Middle Holocene through trace element (Zn, Ca and Fe) analysis; 4) Investigate the micro and macronutritional value of prehistoric foodstuffs, through an analysis of animal and plant remains and to compare the nutritional intake in relation to health and fertility; 5) Establish a chronology of the NDT in the Balkans by summed radiocarbon probability distributions; 6) Explore the possible role of culture in driving fertility increases, through analysis of community attitudes to birthing trough investigation of neonate graves and artifact connected to the birthing process. Given that the issues of health and fertility are of utmost importance in the present as they were in the past, the BIRTH project offers new understanding of biocultural mechanisms which led to fertility increase and novel approaches to ancient skeletal heritage, and emphasizes their great potential for modern humanity.
Max ERC Funding
1 714 880 €
Duration
Start date: 2015-10-01, End date: 2020-09-30
Project acronym FastBio
Project A genomics and systems biology approach to explore the molecular signature and functional consequences of long-term, structured fasting in humans
Researcher (PI) Antigoni DIMA
Host Institution (HI) BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING
Call Details Starting Grant (StG), LS2, ERC-2016-STG
Summary Dietary intake has an enormous impact on aspects of human health, yet scientific consensus about how what we eat affects our biology remains elusive. To address the complex biological impact of diet, I propose to apply an unconventional, ‘humans-as-model-organisms’ approach to compare the molecular and functional effects of a highly structured dietary regime, specified by the Eastern Orthodox Christian Church (EOCC), to the unstructured diet followed by the general population. Individuals who follow the EOCC regime abstain from meat, dairy products and eggs for 180-200 days annually, in a temporally-structured manner initiated in childhood. I aim to explore the biological signatures of structured vs. unstructured diet by addressing three objectives. First I will investigate the effects of the two regimes, and of genetic variation, on higher-level phenotypes including anthropometric, physiological and biomarker traits. Second, I will carry out a comprehensive set of omics assays (metabolomics, transcriptomics, epigenomics and investigation of the gut microbiome), will associate omics phenotypes with genetic variation, and will integrate data across biological levels to uncover complex molecular signatures. Third, I will interrogate the functional consequences of dietary regimes at the cellular level through primary cell culture. Acute and long-term effects of dietary intake will be explored for all objectives through a two timepoint sampling strategy. This proposal therefore comprises a unique opportunity to study a specific perturbation (EOCC structured diet) introduced to a steady-state system (unstructured diet followed by the general population) in a ground-breaking human systems biology type of study. This approach brings together expertise from genomics, computational biology, statistics, medicine and epidemiology. It will lead to novel insights regarding the potent signalling nature of nutrients and is likely to yield results of high translational value.
Summary
Dietary intake has an enormous impact on aspects of human health, yet scientific consensus about how what we eat affects our biology remains elusive. To address the complex biological impact of diet, I propose to apply an unconventional, ‘humans-as-model-organisms’ approach to compare the molecular and functional effects of a highly structured dietary regime, specified by the Eastern Orthodox Christian Church (EOCC), to the unstructured diet followed by the general population. Individuals who follow the EOCC regime abstain from meat, dairy products and eggs for 180-200 days annually, in a temporally-structured manner initiated in childhood. I aim to explore the biological signatures of structured vs. unstructured diet by addressing three objectives. First I will investigate the effects of the two regimes, and of genetic variation, on higher-level phenotypes including anthropometric, physiological and biomarker traits. Second, I will carry out a comprehensive set of omics assays (metabolomics, transcriptomics, epigenomics and investigation of the gut microbiome), will associate omics phenotypes with genetic variation, and will integrate data across biological levels to uncover complex molecular signatures. Third, I will interrogate the functional consequences of dietary regimes at the cellular level through primary cell culture. Acute and long-term effects of dietary intake will be explored for all objectives through a two timepoint sampling strategy. This proposal therefore comprises a unique opportunity to study a specific perturbation (EOCC structured diet) introduced to a steady-state system (unstructured diet followed by the general population) in a ground-breaking human systems biology type of study. This approach brings together expertise from genomics, computational biology, statistics, medicine and epidemiology. It will lead to novel insights regarding the potent signalling nature of nutrients and is likely to yield results of high translational value.
Max ERC Funding
1 500 000 €
Duration
Start date: 2017-06-01, End date: 2022-05-31
Project acronym SeaLiT
Project Seafaring Lives in Transition. Mediterranean Maritime Labour and Shipping during Globalization, 1850s-1920s.
Researcher (PI) Apostolos Delis
Host Institution (HI) IDRYMA TECHNOLOGIAS KAI EREVNAS
Call Details Starting Grant (StG), SH6, ERC-2016-STG
Summary SeaLiT explores the transition from sail to steam navigation and its effects on seafaring populations in the Mediterranean and the Black Sea between the 1850s and the 1920s. In the core of the project lie the effects of technological innovation on seafaring people and maritime communities, whose lives were drastically altered by the advent of steam. The project addresses the changes through the actors, seafarers, shipowners and their families, focusing on the adjustment of seafaring lives to a novel socio-economic reality. It investigates the maritime labour market, the evolving relations among shipowner, captain, crew and their local societies, life on board and ashore, as well as the development of new business strategies, trade routes and navigation patterns.
Maritime labour and shipping remains an understudied case of the transition from the premodern working environment of the sailing ship to that of the steamer, in a period of rapid technological improvements, economic growth and market integration. Therefore, the project will address a major gap in maritime historiography: on the one hand, the transition from sail to steam, and on the other, the Mediterranean and the Black Sea, “the extended Mediterranean” according to F. Braudel.
The project examines in a comparative approach seven maritime regions: the Ionian, Aegean, Tyrrhenian, Adriatic and Black Seas, Spain and southern France. The research team composed of the PI, three postdoctoral fellows, four senior researchers and four Ph.D. candidates from Greece, Italy, Spain, France and Ukraine will study unpublished sources: ship logbooks, crew lists, business records, and private correspondence. They will produce a collective volume, several articles, a final synthesis by the PI, four Ph.D. dissertations, three workshops, one international conference and a website with an online open access database, an archival and bibliographical corpus and reconstruction of ship voyages on a web G.I.S. application.
Summary
SeaLiT explores the transition from sail to steam navigation and its effects on seafaring populations in the Mediterranean and the Black Sea between the 1850s and the 1920s. In the core of the project lie the effects of technological innovation on seafaring people and maritime communities, whose lives were drastically altered by the advent of steam. The project addresses the changes through the actors, seafarers, shipowners and their families, focusing on the adjustment of seafaring lives to a novel socio-economic reality. It investigates the maritime labour market, the evolving relations among shipowner, captain, crew and their local societies, life on board and ashore, as well as the development of new business strategies, trade routes and navigation patterns.
Maritime labour and shipping remains an understudied case of the transition from the premodern working environment of the sailing ship to that of the steamer, in a period of rapid technological improvements, economic growth and market integration. Therefore, the project will address a major gap in maritime historiography: on the one hand, the transition from sail to steam, and on the other, the Mediterranean and the Black Sea, “the extended Mediterranean” according to F. Braudel.
The project examines in a comparative approach seven maritime regions: the Ionian, Aegean, Tyrrhenian, Adriatic and Black Seas, Spain and southern France. The research team composed of the PI, three postdoctoral fellows, four senior researchers and four Ph.D. candidates from Greece, Italy, Spain, France and Ukraine will study unpublished sources: ship logbooks, crew lists, business records, and private correspondence. They will produce a collective volume, several articles, a final synthesis by the PI, four Ph.D. dissertations, three workshops, one international conference and a website with an online open access database, an archival and bibliographical corpus and reconstruction of ship voyages on a web G.I.S. application.
Max ERC Funding
1 372 350 €
Duration
Start date: 2017-02-01, End date: 2022-01-31
Project acronym TRANSARREST
Project Keeping gene expression in check: eliciting the role of transcription in the maintenance of genome integrity
Researcher (PI) Maria Fousteri
Host Institution (HI) BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING
Call Details Starting Grant (StG), LS1, ERC-2012-StG_20111109
Summary Genomic integrity is essential for accurate gene expression and epigenetic inheritance. On the other hand, a prolonged transcriptional arrest can challenge genome stability, contributing to genetic and epigenetic defects and the mechanisms of ageing and disease.
Here we aim to identify the molecular mechanisms that couple transcriptional arrest to chromatin alteration and repair. We wish to explore the idea that transcription suppresses cellular toxicity and preserves genetic and epigenetic inheritance.
Towards these goals our work will be focused on:
1. Deciphering the molecular events impinging on the manner cells respond when the progress of a transcribing RNA polymerase II is blocked.
2. Exploring a novel, so far unanticipated function of key players of the transcription-associated repair pathways, such as the Cockayne Syndrome (CS) proteins, not related to repair.
3. Understanding the role of transcription in chemotherapeutic-driven toxicity.
4. Investigating novel post-translational modifications of CS and determining their function.
These objectives will be addressed using advanced proteomics and genome wide technologies in combination with biochemical and cellular techniques in normal human cells and a large battery of patient-derived cell lines. Our rational is that better understanding of CS function will help reach our ultimate goal, which is to identify the regulatory cascades involved in the interplay between genomic stability and transcription. The novel key idea put forward in this proposal is that active transcription itself directly contributes to genome integrity. While the role of DNA damage-driven transcription blockage in promoting repair is well established, the protective role of active transcription in genome stability is entirely unexplored.
If successful, the proposed studies may help reveal the underlying causes of related disorders and explain their clinical features.
Summary
Genomic integrity is essential for accurate gene expression and epigenetic inheritance. On the other hand, a prolonged transcriptional arrest can challenge genome stability, contributing to genetic and epigenetic defects and the mechanisms of ageing and disease.
Here we aim to identify the molecular mechanisms that couple transcriptional arrest to chromatin alteration and repair. We wish to explore the idea that transcription suppresses cellular toxicity and preserves genetic and epigenetic inheritance.
Towards these goals our work will be focused on:
1. Deciphering the molecular events impinging on the manner cells respond when the progress of a transcribing RNA polymerase II is blocked.
2. Exploring a novel, so far unanticipated function of key players of the transcription-associated repair pathways, such as the Cockayne Syndrome (CS) proteins, not related to repair.
3. Understanding the role of transcription in chemotherapeutic-driven toxicity.
4. Investigating novel post-translational modifications of CS and determining their function.
These objectives will be addressed using advanced proteomics and genome wide technologies in combination with biochemical and cellular techniques in normal human cells and a large battery of patient-derived cell lines. Our rational is that better understanding of CS function will help reach our ultimate goal, which is to identify the regulatory cascades involved in the interplay between genomic stability and transcription. The novel key idea put forward in this proposal is that active transcription itself directly contributes to genome integrity. While the role of DNA damage-driven transcription blockage in promoting repair is well established, the protective role of active transcription in genome stability is entirely unexplored.
If successful, the proposed studies may help reveal the underlying causes of related disorders and explain their clinical features.
Max ERC Funding
1 500 000 €
Duration
Start date: 2012-11-01, End date: 2018-10-31
