Project acronym EXOEARTHS
Project EXtra-solar planets and stellar astrophysics: towards the detection of Other Earths
Researcher (PI) Nuno Miguel Cardoso Santos
Host Institution (HI) CENTRO DE INVESTIGACAO EM ASTRONOMIA E ASTROFISICA DA UNIVERSIDADE DO PORTO
Call Details Starting Grant (StG), PE9, ERC-2009-StG
Summary The detection of more than 300 extrasolar planets orbiting other solar-like stars opened the window to a new field of astrophysics. Many projects to search for Earth-like planets are currently under way, using a huge battery of telescopes and instruments. New instrumentation is also being developed towards this goal for use in both ground- and space-based based facilities. Since planets come as an output of the star formation process, the study of the stars hosting planets is of great importance. The stellar-planet connection is strengthened by the fact that most of the exoplanets were discovered using a Doppler radial-velocity technique, where the gravitational influence of the planet on the star and not the planet itself is actually measured. This project aims at doing frontier research to explore i) in unique detail the stellar limitations of the radial-velocity technique, as well as ways of reducing them, having in mind the detection of Earth-like planets and ii) to develop and apply software packages aiming at the study of the properties of the planet-host stars, having in mind the full characterization of the newfound planets, as well as understanding planet formation processes. These goals will improve our capacity to detect, study, and characterize new very low mass extra-solar planets. EXOEarths further fits into the fact that I am currently Co-PI of the project for a new high-resolution ultra-stable spectrograph for the VLT. The results of this project are crucial to fully exploit this new instrument. They will be also of extreme importance to current state-of-the-art planet-search projects aiming at the discovery of other Earths, in particular those making use of the radial-velocity method.
Summary
The detection of more than 300 extrasolar planets orbiting other solar-like stars opened the window to a new field of astrophysics. Many projects to search for Earth-like planets are currently under way, using a huge battery of telescopes and instruments. New instrumentation is also being developed towards this goal for use in both ground- and space-based based facilities. Since planets come as an output of the star formation process, the study of the stars hosting planets is of great importance. The stellar-planet connection is strengthened by the fact that most of the exoplanets were discovered using a Doppler radial-velocity technique, where the gravitational influence of the planet on the star and not the planet itself is actually measured. This project aims at doing frontier research to explore i) in unique detail the stellar limitations of the radial-velocity technique, as well as ways of reducing them, having in mind the detection of Earth-like planets and ii) to develop and apply software packages aiming at the study of the properties of the planet-host stars, having in mind the full characterization of the newfound planets, as well as understanding planet formation processes. These goals will improve our capacity to detect, study, and characterize new very low mass extra-solar planets. EXOEarths further fits into the fact that I am currently Co-PI of the project for a new high-resolution ultra-stable spectrograph for the VLT. The results of this project are crucial to fully exploit this new instrument. They will be also of extreme importance to current state-of-the-art planet-search projects aiming at the discovery of other Earths, in particular those making use of the radial-velocity method.
Max ERC Funding
928 090 €
Duration
Start date: 2009-10-01, End date: 2014-12-31
Project acronym MIRTURN
Project Mechanisms of microRNA biogenesis and turnover
Researcher (PI) Helge Grosshans
Host Institution (HI) FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION
Call Details Starting Grant (StG), LS2, ERC-2009-StG
Summary MicroRNAs (miRNAs) are a novel class of genes, accounting for >1% of genes in a typical animal genome. They constitute an important layer of gene regulation that affects diverse processes such as cell differentiation, apoptosis, and metabolism. Despite such critical roles, deciphering the mechanism of action of miRNAs has been difficult, leading to multiple, partially contradictory, models of miRNA activity. Moreover, adding an additional layer of complexity, it is now emerging that miRNA activity is regulated by various mechanisms that we are only beginning to identify. Our objective is to understand how miRNAs are regulated under physiological conditions, in the roundworm Caenorhabditis elegans. We will focus on pathways of miRNA turnover, an issue of fundamental importance that has received little attention because miRNAs are widely held to be highly stable molecules. However, miRNA over-accumulation causes aberrant development and disease, prompting us to test rigorously whether degradation can antagonize miRNA activity and either identify the machinery involved, or confirm the dominance of other regulatory modalities, whose components we will identify. C. elegans is the organism in which miRNAs and many components of the miRNA machinery were discovered. However, previous studies emphasized genetics and cell biology approaches, limiting the degree of mechanistic insight that could be obtained. In addition to exploiting the traditional strengths of C. elegans, we will therefore develop and apply biochemical and genomic techniques to obtain a comprehensive understanding of miRNA regulation, enabling us to demonstrate both molecular mechanisms and physiological relevance. Given the importance of miRNAs in development and disease, identifying the regulators of these tiny gene regulators will be both of scientific interest and biomedical relevance.
Summary
MicroRNAs (miRNAs) are a novel class of genes, accounting for >1% of genes in a typical animal genome. They constitute an important layer of gene regulation that affects diverse processes such as cell differentiation, apoptosis, and metabolism. Despite such critical roles, deciphering the mechanism of action of miRNAs has been difficult, leading to multiple, partially contradictory, models of miRNA activity. Moreover, adding an additional layer of complexity, it is now emerging that miRNA activity is regulated by various mechanisms that we are only beginning to identify. Our objective is to understand how miRNAs are regulated under physiological conditions, in the roundworm Caenorhabditis elegans. We will focus on pathways of miRNA turnover, an issue of fundamental importance that has received little attention because miRNAs are widely held to be highly stable molecules. However, miRNA over-accumulation causes aberrant development and disease, prompting us to test rigorously whether degradation can antagonize miRNA activity and either identify the machinery involved, or confirm the dominance of other regulatory modalities, whose components we will identify. C. elegans is the organism in which miRNAs and many components of the miRNA machinery were discovered. However, previous studies emphasized genetics and cell biology approaches, limiting the degree of mechanistic insight that could be obtained. In addition to exploiting the traditional strengths of C. elegans, we will therefore develop and apply biochemical and genomic techniques to obtain a comprehensive understanding of miRNA regulation, enabling us to demonstrate both molecular mechanisms and physiological relevance. Given the importance of miRNAs in development and disease, identifying the regulators of these tiny gene regulators will be both of scientific interest and biomedical relevance.
Max ERC Funding
1 782 200 €
Duration
Start date: 2010-05-01, End date: 2015-04-30
Project acronym PLANETOGENESIS
Project Building the next generation of planet formation models: protoplanetary disks, internal structure, and formation of planetary systems
Researcher (PI) Yann Alibert
Host Institution (HI) UNIVERSITAET BERN
Call Details Starting Grant (StG), PE9, ERC-2009-StG
Summary The discovery of extra-solar planetary systems with properties so different from those of our own Solar System has overturned our theoretical understanding of how planets and planetary systems form. Indeed, planet formation models have to link observations of two classes of objects: Protoplanetary disk, whose structure and early evolution provide the initial conditions of planets formation, and actual detected planets. The observational knowledge of these two classes of objects will see in the near future dramatic improvements, with three major breakthroughs: 1) high angular resolution observations will tightly constrain the structure and early evolution of protoplanetary disks, 2) direct observation of extrasolar planets will allow to understand their internal structure as well as their formation process, and 3) detection of very low mass extrasolar planets will constrain the mass function of planets and planetary systems, down to the terrestrial planet regime The goal of this project is to develop a theoretical understanding of planet formation that quantitatively stands up to these observational confrontations. For this, we will build on the basis of first generation planet formation models developed at the time the PI was assistant at the Physikalisches Institute of the University of Berne. The PI, a PhD student, and a Postdoc will conduct three inter-related sub-projects linked to the three breakthroughs mentioned above: A) improving the disk part of planet formation models, B) determining the internal structure of forming planets, including the effects of accretion shocks and envelope pollution by infalling planetesimals, and calculating their early evolution, and C) building planetary system formation models, including both gas giant and low mass rocky planets.
Summary
The discovery of extra-solar planetary systems with properties so different from those of our own Solar System has overturned our theoretical understanding of how planets and planetary systems form. Indeed, planet formation models have to link observations of two classes of objects: Protoplanetary disk, whose structure and early evolution provide the initial conditions of planets formation, and actual detected planets. The observational knowledge of these two classes of objects will see in the near future dramatic improvements, with three major breakthroughs: 1) high angular resolution observations will tightly constrain the structure and early evolution of protoplanetary disks, 2) direct observation of extrasolar planets will allow to understand their internal structure as well as their formation process, and 3) detection of very low mass extrasolar planets will constrain the mass function of planets and planetary systems, down to the terrestrial planet regime The goal of this project is to develop a theoretical understanding of planet formation that quantitatively stands up to these observational confrontations. For this, we will build on the basis of first generation planet formation models developed at the time the PI was assistant at the Physikalisches Institute of the University of Berne. The PI, a PhD student, and a Postdoc will conduct three inter-related sub-projects linked to the three breakthroughs mentioned above: A) improving the disk part of planet formation models, B) determining the internal structure of forming planets, including the effects of accretion shocks and envelope pollution by infalling planetesimals, and calculating their early evolution, and C) building planetary system formation models, including both gas giant and low mass rocky planets.
Max ERC Funding
1 395 323 €
Duration
Start date: 2010-02-01, End date: 2015-11-30
Project acronym RECONMET
Project Reconstruction of methane flux from lakes: development and application of a new approach
Researcher (PI) Oliver Heiri
Host Institution (HI) UNIVERSITAET BERN
Call Details Starting Grant (StG), PE10, ERC-2009-StG
Summary Reconstruction of methane flux from lakes: development and application of a new approach
Summary
Reconstruction of methane flux from lakes: development and application of a new approach
Max ERC Funding
1 554 000 €
Duration
Start date: 2009-12-01, End date: 2014-11-30
Project acronym SEXGENTRANSEVOLUTION
Project Sex-biased genome and transcriptome evolution in mammals
Researcher (PI) Henrik Kaessmann
Host Institution (HI) UNIVERSITE DE LAUSANNE
Call Details Starting Grant (StG), LS2, ERC-2009-StG
Summary Mammalian males and females have many phenotypic differences. These differences, collectively referred to as sexual dimorphism, are the consequence of natural and sexual selection for phenotypic traits that affect the fitness of each sex and are encoded in the genome. Part of the underlying genomic differences between the sexes are found on sex specific (the Y) or sex biased chromosomes (the X), while many sexually dimorphic traits probably result from autosomal gene expression differences in sex specific or somatic tissues. However, the origin and evolution of sex-biased genes in mammals has not been studied in detail. I propose to generate the first detailed qualitative and quantitative transcriptome data using next generation sequencing technologies for a unique collection of germline and somatic tissues from representatives of all major mammalian lineages: placental mammals, marsupials, and the egg-laying monotremes. Together with detailed transcriptome data from birds (the evolutionary sister lineage), complementary experiments (e.g. methylome analyses), and available genomic resources from these species, these unprecedented data will allow an integrated analysis of the origin and functional evolution of mammalian sex chromosomes, the emergence of new sex biased genes, and the evolution of gene expression in germline versus somatic tissues in mammals at large. The proposed work will thus substantially increase our power to understand how mammalian genomes evolved the capacity to produce such pronounced sexually dimorphic traits. Beyond research pertaining to sex biased genome evolution, our data will represent a unique resource for future investigations of mammalian gene functions and serve as a basis for exploring the evolution of other mammal specific phenotypes.
Summary
Mammalian males and females have many phenotypic differences. These differences, collectively referred to as sexual dimorphism, are the consequence of natural and sexual selection for phenotypic traits that affect the fitness of each sex and are encoded in the genome. Part of the underlying genomic differences between the sexes are found on sex specific (the Y) or sex biased chromosomes (the X), while many sexually dimorphic traits probably result from autosomal gene expression differences in sex specific or somatic tissues. However, the origin and evolution of sex-biased genes in mammals has not been studied in detail. I propose to generate the first detailed qualitative and quantitative transcriptome data using next generation sequencing technologies for a unique collection of germline and somatic tissues from representatives of all major mammalian lineages: placental mammals, marsupials, and the egg-laying monotremes. Together with detailed transcriptome data from birds (the evolutionary sister lineage), complementary experiments (e.g. methylome analyses), and available genomic resources from these species, these unprecedented data will allow an integrated analysis of the origin and functional evolution of mammalian sex chromosomes, the emergence of new sex biased genes, and the evolution of gene expression in germline versus somatic tissues in mammals at large. The proposed work will thus substantially increase our power to understand how mammalian genomes evolved the capacity to produce such pronounced sexually dimorphic traits. Beyond research pertaining to sex biased genome evolution, our data will represent a unique resource for future investigations of mammalian gene functions and serve as a basis for exploring the evolution of other mammal specific phenotypes.
Max ERC Funding
1 901 522 €
Duration
Start date: 2010-02-01, End date: 2015-01-31
Project acronym UMICIS
Project Uncultivated Microbes In Situ - a Computational Biology Approach to Determine Molecular Capabilities and Ecological Roles
Researcher (PI) Christian Von Mering
Host Institution (HI) UNIVERSITAT ZURICH
Call Details Starting Grant (StG), LS2, ERC-2009-StG
Summary Most of nature s biodiversity, and many potentially useful metabolic capabilities, remain hidden among the vast numbers of uncharacterized environmental microbes. Because cultivation is still not possible for most of these microbes, cultivation-independent molecular techniques such as polymerase chain reaction (PCR), fluorescent in situ hybridization (FISH), or shotgun DNA sequencing have been used in order to study their function and ecology in their natural habitats. However, none of the above techniques have so far been sufficient for any systematic assignment of molecular functions to distinct microbial lineages. Thus, most of the molecular ecology of natural microbes remains elusive. Here, we propose a computational meta-analysis and synthesis of existing and newly generated molecular sequence data sampled directly from the environment combining DNA sequencing data (metagenomics), and proteome expression data (metaproteomics). This analysis will be coupled to computational modelling of genome content evolution at the community level. We will aim to assess how gene repertoires of microbial communities, and their taxonomic compositions, change across distinct environments, in response to changed conditions, and through time. We plan to address fundamental questions in microbial ecology, including the extent of cooperation among members of the communities, stability of community composition at evolutionary timescales, the importance of lateral gene transfers, the extent of functional adaptation/regulation in situ, and whether gene occurrence and expression patterns are diagnostic of community functions and ecological status.
Summary
Most of nature s biodiversity, and many potentially useful metabolic capabilities, remain hidden among the vast numbers of uncharacterized environmental microbes. Because cultivation is still not possible for most of these microbes, cultivation-independent molecular techniques such as polymerase chain reaction (PCR), fluorescent in situ hybridization (FISH), or shotgun DNA sequencing have been used in order to study their function and ecology in their natural habitats. However, none of the above techniques have so far been sufficient for any systematic assignment of molecular functions to distinct microbial lineages. Thus, most of the molecular ecology of natural microbes remains elusive. Here, we propose a computational meta-analysis and synthesis of existing and newly generated molecular sequence data sampled directly from the environment combining DNA sequencing data (metagenomics), and proteome expression data (metaproteomics). This analysis will be coupled to computational modelling of genome content evolution at the community level. We will aim to assess how gene repertoires of microbial communities, and their taxonomic compositions, change across distinct environments, in response to changed conditions, and through time. We plan to address fundamental questions in microbial ecology, including the extent of cooperation among members of the communities, stability of community composition at evolutionary timescales, the importance of lateral gene transfers, the extent of functional adaptation/regulation in situ, and whether gene occurrence and expression patterns are diagnostic of community functions and ecological status.
Max ERC Funding
1 129 800 €
Duration
Start date: 2010-02-01, End date: 2016-01-31
