Project acronym BeyondMoore
Project Pioneering a New Path in Parallel Programming Beyond Moore’s Law
Researcher (PI) Didem UNAT
Host Institution (HI) KOC UNIVERSITY
Country Turkey
Call Details Starting Grant (StG), PE6, ERC-2020-STG
Summary BEYONDMOORE addresses the timely research challenge of solving the software side of the Post Moore crisis. The techno-economical model in computing, known as the Moore’s Law, has led to an exceptionally productive era for humanity and numerous scientific discoveries over the past 50+ years. However, due to the fundamental limits in chip manufacturing we are about to mark the end of Moore’s Law and enter a new era of computing where continued performance improvement will likely emerge from extreme heterogeneity. The new systems are expected to bring a diverse set of hardware accelerators and memory technologies. Current solutions to program such systems are host-centric, where the host processor orchestrates the entire execution. This poses major scalability issues and severely limits the types of parallelism that can be exploited. Unless there is a fundamental change in our approach to heterogeneous parallel programming, we risk substantially underutilizing upcoming systems. BEYONDMOORE offers a way out of this programming crisis and proposes an autonomous execution model that is more scalable, flexible, and accelerator-centric by design. In this model, accelerators have autonomy; they compute, collaborate, and communicate with each other without the involvement of the host. The execution model is powered with a rich set of programming abstractions that enable a program to be modeled as a task graph. To efficiently execute this task graph, BEYONDMOORE will develop a software framework that performs static and dynamic optimizations, issues accelerator-initiated data transfers, and reasons about parallel execution strategies that exploit both processor and memory heterogeneity. To aid the optimizations, a comprehensive cost model that characterizes both target applications and emerging architectures will be devised. Complete success of BEYONDMOORE will enable continued progress in computing which in turn will power science and technology in the life after Moore’s Law.
Summary
BEYONDMOORE addresses the timely research challenge of solving the software side of the Post Moore crisis. The techno-economical model in computing, known as the Moore’s Law, has led to an exceptionally productive era for humanity and numerous scientific discoveries over the past 50+ years. However, due to the fundamental limits in chip manufacturing we are about to mark the end of Moore’s Law and enter a new era of computing where continued performance improvement will likely emerge from extreme heterogeneity. The new systems are expected to bring a diverse set of hardware accelerators and memory technologies. Current solutions to program such systems are host-centric, where the host processor orchestrates the entire execution. This poses major scalability issues and severely limits the types of parallelism that can be exploited. Unless there is a fundamental change in our approach to heterogeneous parallel programming, we risk substantially underutilizing upcoming systems. BEYONDMOORE offers a way out of this programming crisis and proposes an autonomous execution model that is more scalable, flexible, and accelerator-centric by design. In this model, accelerators have autonomy; they compute, collaborate, and communicate with each other without the involvement of the host. The execution model is powered with a rich set of programming abstractions that enable a program to be modeled as a task graph. To efficiently execute this task graph, BEYONDMOORE will develop a software framework that performs static and dynamic optimizations, issues accelerator-initiated data transfers, and reasons about parallel execution strategies that exploit both processor and memory heterogeneity. To aid the optimizations, a comprehensive cost model that characterizes both target applications and emerging architectures will be devised. Complete success of BEYONDMOORE will enable continued progress in computing which in turn will power science and technology in the life after Moore’s Law.
Max ERC Funding
1 500 000 €
Duration
Start date: 2021-08-01, End date: 2026-07-31
Project acronym CentSatRegFunc
Project Dissecting the function and regulation of centriolar satellites: key regulators of the centrosome/cilium complex
Researcher (PI) Elif Nur Firat Karalar
Host Institution (HI) KOC UNIVERSITY
Country Turkey
Call Details Starting Grant (StG), LS3, ERC-2015-STG
Summary Centrosomes are the main microtubule-organizing centers of animal cells. They influence the morphology of the microtubule cytoskeleton and function as the base of primary cilium, a nexus for important signaling pathways. Structural and functional defects in centrosome/cilium complex cause a variety of human diseases including cancer, ciliopathies and microcephaly. To understand the relationship between human diseases and centrosome/cilium abnormalities, it is essential to elucidate the biogenesis of centrosome/cilium complex and the control mechanisms that regulate their structure and function. To tackle these fundamental problems, we will dissect the function and regulation of centriolar satellites, the array of granules that localize around the centrosome/cilium complex in mammalian cells. Only recently interest in the satellites has grown because mutations affecting satellite components were shown to cause ciliopathies, microcephaly and schizophrenia.
Remarkably, many centrosome/cilium proteins localize to these structures and we lack understanding of when, why and how these proteins localize to satellites. The central hypothesis of this grant is that satellites ensure proper centrosome/cilium complex structure and function by acting as transit paths for modification, assembly, storage, stability and trafficking of centrosome/cilium proteins. In Aim 1, we will identify the nature of regulatory and molecular relationship between satellites and the centrosome/cilium complex. In Aim 2, we will elucidate the role of satellites in proteostasis of centrosome/cilium proteins. In Aim 3, we will investigate the functional significance of satellite-localization of centrosome/cilium proteins during processes that go awry in human disease. Using a multidisciplinary approach, the proposed research will expand our knowledge of the spatiotemporal regulation of the centrosome/cilium complex and provide new insights into pathogenesis of ciliopathies and primary microcephaly.
Summary
Centrosomes are the main microtubule-organizing centers of animal cells. They influence the morphology of the microtubule cytoskeleton and function as the base of primary cilium, a nexus for important signaling pathways. Structural and functional defects in centrosome/cilium complex cause a variety of human diseases including cancer, ciliopathies and microcephaly. To understand the relationship between human diseases and centrosome/cilium abnormalities, it is essential to elucidate the biogenesis of centrosome/cilium complex and the control mechanisms that regulate their structure and function. To tackle these fundamental problems, we will dissect the function and regulation of centriolar satellites, the array of granules that localize around the centrosome/cilium complex in mammalian cells. Only recently interest in the satellites has grown because mutations affecting satellite components were shown to cause ciliopathies, microcephaly and schizophrenia.
Remarkably, many centrosome/cilium proteins localize to these structures and we lack understanding of when, why and how these proteins localize to satellites. The central hypothesis of this grant is that satellites ensure proper centrosome/cilium complex structure and function by acting as transit paths for modification, assembly, storage, stability and trafficking of centrosome/cilium proteins. In Aim 1, we will identify the nature of regulatory and molecular relationship between satellites and the centrosome/cilium complex. In Aim 2, we will elucidate the role of satellites in proteostasis of centrosome/cilium proteins. In Aim 3, we will investigate the functional significance of satellite-localization of centrosome/cilium proteins during processes that go awry in human disease. Using a multidisciplinary approach, the proposed research will expand our knowledge of the spatiotemporal regulation of the centrosome/cilium complex and provide new insights into pathogenesis of ciliopathies and primary microcephaly.
Max ERC Funding
1 499 819 €
Duration
Start date: 2016-06-01, End date: 2022-05-31
Project acronym COSMOS
Project Computational Simulations of MOFs for Gas Separations
Researcher (PI) Seda Keskin Avci
Host Institution (HI) KOC UNIVERSITY
Country Turkey
Call Details Starting Grant (StG), PE8, ERC-2017-STG
Summary Metal organic frameworks (MOFs) are recently considered as new fascinating nanoporous materials. MOFs have very large surface areas, high porosities, various pore sizes/shapes, chemical functionalities and good thermal/chemical stabilities. These properties make MOFs highly promising for gas separation applications. Thousands of MOFs have been synthesized in the last decade. The large number of available MOFs creates excellent opportunities to develop energy-efficient gas separation technologies. On the other hand, it is very challenging to identify the best materials for each gas separation of interest. Considering the continuous rapid increase in the number of synthesized materials, it is practically not possible to test each MOF using purely experimental manners. Highly accurate computational methods are required to identify the most promising MOFs to direct experimental efforts, time and resources to those materials. In this project, I will build a complete MOF library and use molecular simulations to assess adsorption and diffusion properties of gas mixtures in MOFs. Results of simulations will be used to predict adsorbent and membrane properties of MOFs for scientifically and technologically important gas separation processes such as CO2/CH4 (natural gas purification), CO2/N2 (flue gas separation), CO2/H2, CH4/H2 and N2/H2 (hydrogen recovery). I will obtain the fundamental, atomic-level insights into the common features of the top-performing MOFs and establish structure-performance relations. These relations will be used as guidelines to computationally design new MOFs with outstanding separation performances for CO2 capture and H2 recovery. These new MOFs will be finally synthesized in the lab scale and tested as adsorbents and membranes under practical operating conditions for each gas separation of interest. Combining a multi-stage computational approach with experiments, this project will lead to novel, efficient gas separation technologies based on MOFs.
Summary
Metal organic frameworks (MOFs) are recently considered as new fascinating nanoporous materials. MOFs have very large surface areas, high porosities, various pore sizes/shapes, chemical functionalities and good thermal/chemical stabilities. These properties make MOFs highly promising for gas separation applications. Thousands of MOFs have been synthesized in the last decade. The large number of available MOFs creates excellent opportunities to develop energy-efficient gas separation technologies. On the other hand, it is very challenging to identify the best materials for each gas separation of interest. Considering the continuous rapid increase in the number of synthesized materials, it is practically not possible to test each MOF using purely experimental manners. Highly accurate computational methods are required to identify the most promising MOFs to direct experimental efforts, time and resources to those materials. In this project, I will build a complete MOF library and use molecular simulations to assess adsorption and diffusion properties of gas mixtures in MOFs. Results of simulations will be used to predict adsorbent and membrane properties of MOFs for scientifically and technologically important gas separation processes such as CO2/CH4 (natural gas purification), CO2/N2 (flue gas separation), CO2/H2, CH4/H2 and N2/H2 (hydrogen recovery). I will obtain the fundamental, atomic-level insights into the common features of the top-performing MOFs and establish structure-performance relations. These relations will be used as guidelines to computationally design new MOFs with outstanding separation performances for CO2 capture and H2 recovery. These new MOFs will be finally synthesized in the lab scale and tested as adsorbents and membranes under practical operating conditions for each gas separation of interest. Combining a multi-stage computational approach with experiments, this project will lead to novel, efficient gas separation technologies based on MOFs.
Max ERC Funding
1 500 000 €
Duration
Start date: 2017-10-01, End date: 2022-09-30
Project acronym EmergingWelfare
Project The New Politics of Welfare: Towards an “Emerging Markets” Welfare State Regime
Researcher (PI) Erdem YORUK
Host Institution (HI) KOC UNIVERSITY
Country Turkey
Call Details Starting Grant (StG), SH3, ERC-2016-STG
Summary This research project aims to identify a new welfare regime in emerging market economies and explain why
it has emerged. The project will compare Brazil, China, India, Indonesia, Mexico, South Africa and Turkey
to test two hypotheses: (i) emerging market economies are forming a new welfare regime that differs from
liberal, corporatist and social democratic welfare regimes of the global north on the basis of extensive and
decommodifying social assistance programmes, (ii) the new welfare regime emerges principally as a
response to the growing political power of the poor as a dual source of threat and support for governments.
Based on a comparative and interdisciplinary perspective, the project follows a multi-method strategy that
combines state-of-the-art computer-based protest event data collection techniques, macro-historical methods,
quantitative data analyses and qualitative content analysis. The project will radically expand the literatures
on welfare regimes, welfare state development and contentious politics, by challenging the existing
paradigms dominated by structuralist perspectives, a myopic focus on Western countries, and limited data
collection and analysis techniques. This project is genuinely innovative, unprecedented, ground-breaking,
ambitious and high-risk/high-gain in three ways: (i) it re-shapes the welfare regimes literatures as the first
study to classify and explain welfare systems of emerging markets as a new welfare regime and (ii) the
project demonstrates a causal link between changes in grassroots politics and welfare policies and challenge
the structuralist preponderance in the existing welfare state development literature (iii) it makes a prodigious
contribution to our empirical knowledge on contentious politics in emerging markets by creating the first
cross-national databases on protest event, employing state-of-the art computer methods, such as natural
language processing and machine learning, on newspaper archives.
Summary
This research project aims to identify a new welfare regime in emerging market economies and explain why
it has emerged. The project will compare Brazil, China, India, Indonesia, Mexico, South Africa and Turkey
to test two hypotheses: (i) emerging market economies are forming a new welfare regime that differs from
liberal, corporatist and social democratic welfare regimes of the global north on the basis of extensive and
decommodifying social assistance programmes, (ii) the new welfare regime emerges principally as a
response to the growing political power of the poor as a dual source of threat and support for governments.
Based on a comparative and interdisciplinary perspective, the project follows a multi-method strategy that
combines state-of-the-art computer-based protest event data collection techniques, macro-historical methods,
quantitative data analyses and qualitative content analysis. The project will radically expand the literatures
on welfare regimes, welfare state development and contentious politics, by challenging the existing
paradigms dominated by structuralist perspectives, a myopic focus on Western countries, and limited data
collection and analysis techniques. This project is genuinely innovative, unprecedented, ground-breaking,
ambitious and high-risk/high-gain in three ways: (i) it re-shapes the welfare regimes literatures as the first
study to classify and explain welfare systems of emerging markets as a new welfare regime and (ii) the
project demonstrates a causal link between changes in grassroots politics and welfare policies and challenge
the structuralist preponderance in the existing welfare state development literature (iii) it makes a prodigious
contribution to our empirical knowledge on contentious politics in emerging markets by creating the first
cross-national databases on protest event, employing state-of-the art computer methods, such as natural
language processing and machine learning, on newspaper archives.
Max ERC Funding
1 494 240 €
Duration
Start date: 2017-01-01, End date: 2021-12-31
Project acronym INFIBRENANOSTRUCTURE
Project Fabrication and characterization of dielectric encapsulated millions of ordered kilometer-long nanostructures and their applications
Researcher (PI) Mehmet Bayindir
Host Institution (HI) BILKENT UNIVERSITESI VAKIF
Country Turkey
Call Details Starting Grant (StG), PE5, ERC-2012-StG_20111012
Summary The objective of this project is the realization of a radically new nanowire fabrication technique, and exploration of its potential for nanowire based science and technology. The proposed method involves fabrication of unusually long, ordered nanowire and nanotube arrays in macroscopic fibres by means of an iterative thermal co-drawing process. Starting with a macroscopic rod with an annular hole tightly fitted with another rod of another compatible material, by successive thermal drawing we obtain arrays of nanowires embedded in fibres. With the method, wide range of materials, e.g. semiconductors, polymers, metals, can be turned into ordered nanorods, nanowires, nanotubes in various cross-sectional geometries. Main challenges are the thermal drawing steps that require critical matching of the viscoelastic properties of the protective cover with the encapsulated materials, and the liquid instability problems and phase intermixing with higher temperatures and smaller feature sizes that require high thermal and mechanical precision. Initially, fabrication by drawing will begin with soft amorphous semiconductors, phase change materials, polymers of interest in high temperature polymers, followed by a wider range of materials, low melting temperature metals, metals and common semiconductors (Si, Ge) in silica glass matrices. In this way nanowires that are ordered, easily accessible and hermetically sealed in a dielectric encapsulation will be obtained in high volumes. Potentially, these nanowires are advantages over on-chip nanowires in building flexible out of plane geometries, light weight, wearable and disposable devices. Ultimately, attaining ordered arrays of 1-D nanostructures in an extended flexible fibre with high yields will facilitate sought-after but up-to-now difficult applications such as the large area nanowire electronics and photonics, nanowire based scalable phase-change memory, nanowire photovoltaics, and emerging cell-nanowire interfacing.
Summary
The objective of this project is the realization of a radically new nanowire fabrication technique, and exploration of its potential for nanowire based science and technology. The proposed method involves fabrication of unusually long, ordered nanowire and nanotube arrays in macroscopic fibres by means of an iterative thermal co-drawing process. Starting with a macroscopic rod with an annular hole tightly fitted with another rod of another compatible material, by successive thermal drawing we obtain arrays of nanowires embedded in fibres. With the method, wide range of materials, e.g. semiconductors, polymers, metals, can be turned into ordered nanorods, nanowires, nanotubes in various cross-sectional geometries. Main challenges are the thermal drawing steps that require critical matching of the viscoelastic properties of the protective cover with the encapsulated materials, and the liquid instability problems and phase intermixing with higher temperatures and smaller feature sizes that require high thermal and mechanical precision. Initially, fabrication by drawing will begin with soft amorphous semiconductors, phase change materials, polymers of interest in high temperature polymers, followed by a wider range of materials, low melting temperature metals, metals and common semiconductors (Si, Ge) in silica glass matrices. In this way nanowires that are ordered, easily accessible and hermetically sealed in a dielectric encapsulation will be obtained in high volumes. Potentially, these nanowires are advantages over on-chip nanowires in building flexible out of plane geometries, light weight, wearable and disposable devices. Ultimately, attaining ordered arrays of 1-D nanostructures in an extended flexible fibre with high yields will facilitate sought-after but up-to-now difficult applications such as the large area nanowire electronics and photonics, nanowire based scalable phase-change memory, nanowire photovoltaics, and emerging cell-nanowire interfacing.
Max ERC Funding
1 495 400 €
Duration
Start date: 2012-10-01, End date: 2017-09-30
Project acronym INFRADYNAMICS
Project Overcoming the Barriers of Brain Cancer Treatment: Targeted and Fully NIR Absorbing Photodynamic Therapy Agents with Extremely Low Molecular Weights and Controlled Lipophilicity
Researcher (PI) Gorkem GUNBAS
Host Institution (HI) MIDDLE EAST TECHNICAL UNIVERSITY
Country Turkey
Call Details Starting Grant (StG), PE5, ERC-2019-STG
Summary Cancer is the second leading cause of death worldwide, accounting for a total of 8.8 million deaths in 2015. Research efforts have resulted in significant increase in 5-year survival rates for some cancer types, however this is not the case in brain cancer. Three fundamental issues are at the core of this reality: 1) High percentage of inoperable brain tumours; 2) Limited number of drugs that can pass through the blood-brain barrier and 3) Absence of effective targeted brain cancer therapies. Photodynamic therapy (PDT) has the potential to be a selective, effective and non-invasive alternative to current treatments, however to date it is only applicable to a small group of cancers. Realization of non-toxic, water-soluble and photostable PDT agents, with strong near infrared absorption for deep tissue penetration, that also realizes high singlet oxygen generation efficiency and effective targeting, is the key for widespread use of PDT for majority of cancers. For brain cancer specifically, low molecular weights (Mws) and controlled lipophilicity is needed as well. The ultimate aim of INFRADYNAMICS is to create and validate the first series of advanced PDT agents that meet all these requirements and to demonstrate that a significant impact on brain cancer survival rates could be achieved. First, a series of advanced fluorophores that combine the two contradicting entities – absorption in NIR region (>700 nm) and low Mws – will be realized using novel design approaches which also allow a synthetically-viable pathway to tune lipophilicity. Then, appropriate heavy atom modifications for sensitization will be pursued. Most importantly, these sensitizers will be decorated with known and novel handles towards specific targeting of glioblastoma cells to attain the final PDT agents. Photophysical properties will be investigated, and finally, in-vitro and in-vivo studies will be performed to determine the effectiveness of our agents on brain cancer treatment.
Summary
Cancer is the second leading cause of death worldwide, accounting for a total of 8.8 million deaths in 2015. Research efforts have resulted in significant increase in 5-year survival rates for some cancer types, however this is not the case in brain cancer. Three fundamental issues are at the core of this reality: 1) High percentage of inoperable brain tumours; 2) Limited number of drugs that can pass through the blood-brain barrier and 3) Absence of effective targeted brain cancer therapies. Photodynamic therapy (PDT) has the potential to be a selective, effective and non-invasive alternative to current treatments, however to date it is only applicable to a small group of cancers. Realization of non-toxic, water-soluble and photostable PDT agents, with strong near infrared absorption for deep tissue penetration, that also realizes high singlet oxygen generation efficiency and effective targeting, is the key for widespread use of PDT for majority of cancers. For brain cancer specifically, low molecular weights (Mws) and controlled lipophilicity is needed as well. The ultimate aim of INFRADYNAMICS is to create and validate the first series of advanced PDT agents that meet all these requirements and to demonstrate that a significant impact on brain cancer survival rates could be achieved. First, a series of advanced fluorophores that combine the two contradicting entities – absorption in NIR region (>700 nm) and low Mws – will be realized using novel design approaches which also allow a synthetically-viable pathway to tune lipophilicity. Then, appropriate heavy atom modifications for sensitization will be pursued. Most importantly, these sensitizers will be decorated with known and novel handles towards specific targeting of glioblastoma cells to attain the final PDT agents. Photophysical properties will be investigated, and finally, in-vitro and in-vivo studies will be performed to determine the effectiveness of our agents on brain cancer treatment.
Max ERC Funding
1 500 000 €
Duration
Start date: 2019-11-01, End date: 2024-10-31
Project acronym METARNAFLAMMATION
Project The RNA bridge between IRE-1 and PKR leading to metaflammation: discovery and intervention in atherosclerosis
Researcher (PI) Ebru Erbay
Host Institution (HI) BILKENT UNIVERSITESI VAKIF
Country Turkey
Call Details Starting Grant (StG), LS4, ERC-2013-StG
Summary A close functional and molecular integration between metabolic and immune systems is crucial for systemic homeostasis and its’ deregulation is causally linked to obesity and associated diseases including insulin resistance, diabetes and atherosclerosis and known as cardiometabolic syndrome (CMS). Metabolic overload initiates a chronic inflammatory and stress response known as metaflammation and promotes the complications of CMS. The precise molecular mechanisms linking metabolic stress to immune activation and stress responses, however, remain elusive.
Earlier studies demonstrated metabolic overload stresses the endoplasmic reticulum (ER) and activates the unfolded protein response (UPR). ER is a critical intracellular metabolic hub orchestrating protein, lipid and calcium metabolism. These vital functions of ER are maintained by a conserved, adaptive stress response or UPR that emanates from its membranes. ER stress has emerged as a central paradigm in the pathogenesis of CMS and its reduction prevents atherosclerosis and promotes insulin sensitivity. However, a clear understanding of how metabolic stress is sensed and communicated by the ER is fundamental in designing specific and targeted therapy to ER stress in CMS. This application will investigate the ER stress response that can sense excess lipids and couple to inflammatory and stress responses, and whether its unique operation under metabolic stress can be suitable for therapeutic exploitation in CMS. This proposal tackles the unique modes of operation of two important players in the ER stress response that are coupled by metabolic stress, inositol-requiring enzyme-1 (IRE-1) and double-stranded RNA-activated kinase (PKR), by taking advantage of chemical-genetics to specifically modify their activities. When completed the proposed studies will have shed light on a little explored but central question in the field of immunometabolism regarding how nutrients engage inflammatory and stress pathways.
Summary
A close functional and molecular integration between metabolic and immune systems is crucial for systemic homeostasis and its’ deregulation is causally linked to obesity and associated diseases including insulin resistance, diabetes and atherosclerosis and known as cardiometabolic syndrome (CMS). Metabolic overload initiates a chronic inflammatory and stress response known as metaflammation and promotes the complications of CMS. The precise molecular mechanisms linking metabolic stress to immune activation and stress responses, however, remain elusive.
Earlier studies demonstrated metabolic overload stresses the endoplasmic reticulum (ER) and activates the unfolded protein response (UPR). ER is a critical intracellular metabolic hub orchestrating protein, lipid and calcium metabolism. These vital functions of ER are maintained by a conserved, adaptive stress response or UPR that emanates from its membranes. ER stress has emerged as a central paradigm in the pathogenesis of CMS and its reduction prevents atherosclerosis and promotes insulin sensitivity. However, a clear understanding of how metabolic stress is sensed and communicated by the ER is fundamental in designing specific and targeted therapy to ER stress in CMS. This application will investigate the ER stress response that can sense excess lipids and couple to inflammatory and stress responses, and whether its unique operation under metabolic stress can be suitable for therapeutic exploitation in CMS. This proposal tackles the unique modes of operation of two important players in the ER stress response that are coupled by metabolic stress, inositol-requiring enzyme-1 (IRE-1) and double-stranded RNA-activated kinase (PKR), by taking advantage of chemical-genetics to specifically modify their activities. When completed the proposed studies will have shed light on a little explored but central question in the field of immunometabolism regarding how nutrients engage inflammatory and stress pathways.
Max ERC Funding
1 362 921 €
Duration
Start date: 2014-01-01, End date: 2018-06-30
Project acronym NONWESTLIT
Project Modernizing Empires: Enlightenment, Nationalist Vanguards and Non-Western Literary Modernities
Researcher (PI) Ozen Nergis Dolcerocca
Host Institution (HI) KOC UNIVERSITY
Country Turkey
Call Details Starting Grant (StG), SH5, ERC-2020-STG
Summary This project is a comparative study of cultural reforms, linguistic renewal and literary renaissance movements in three imperial traditions, caught between the East-West divide: Russia, Turkey and Japan. It looks at the negotiated cultural models in modernization and westernization processes and argues that their shared historical experience resulted in a common intellectual vocabulary and narrative models shared by otherwise extremely diverse cultures. Despite these unmistakable parallels, literary studies have failed to address this shared history. This project aims to bridge this gap by developing a comparative model, drawing a polycentric and plural map of literary modernity. In three subprojects, this project investigates structural similarities in 1.Questions and concepts in literary criticism; 2.Translational practices and translated works from Europe, and 3.Narrative logic and typologies in fiction. It is the first comparative multilingual study of the non-Western literary modernities to bring these specific traditions together. It contests Eurocentric models of literary history which interprets these cases as failures or late emulations. It challenges an overemphasis on single national traditions or on postcolonial approaches, and limited body of studied texts and analysis techniques in the study of the non-West. The project follows a multi-method research strategy to conduct historical and literary comparisons between the emerging national literary systems, combining qualitative and quantitative methods in order to map transnational networks of narrative strategies, conceptual systems and translation practices. It brings new directions in Digital Humanities, expanding it to non-Western and multilingual comparative research. Finally, it makes a much-needed contribution to the current literary corpus by making unknown and untranslated texts available and accessible.
Summary
This project is a comparative study of cultural reforms, linguistic renewal and literary renaissance movements in three imperial traditions, caught between the East-West divide: Russia, Turkey and Japan. It looks at the negotiated cultural models in modernization and westernization processes and argues that their shared historical experience resulted in a common intellectual vocabulary and narrative models shared by otherwise extremely diverse cultures. Despite these unmistakable parallels, literary studies have failed to address this shared history. This project aims to bridge this gap by developing a comparative model, drawing a polycentric and plural map of literary modernity. In three subprojects, this project investigates structural similarities in 1.Questions and concepts in literary criticism; 2.Translational practices and translated works from Europe, and 3.Narrative logic and typologies in fiction. It is the first comparative multilingual study of the non-Western literary modernities to bring these specific traditions together. It contests Eurocentric models of literary history which interprets these cases as failures or late emulations. It challenges an overemphasis on single national traditions or on postcolonial approaches, and limited body of studied texts and analysis techniques in the study of the non-West. The project follows a multi-method research strategy to conduct historical and literary comparisons between the emerging national literary systems, combining qualitative and quantitative methods in order to map transnational networks of narrative strategies, conceptual systems and translation practices. It brings new directions in Digital Humanities, expanding it to non-Western and multilingual comparative research. Finally, it makes a much-needed contribution to the current literary corpus by making unknown and untranslated texts available and accessible.
Max ERC Funding
1 457 660 €
Duration
Start date: 2021-09-01, End date: 2026-08-31
Project acronym NOVELNOBI
Project Novel Nanoengineered Optoelectronic Biointerfaces
Researcher (PI) Sedat Nizamoglu
Host Institution (HI) KOC UNIVERSITY
Country Turkey
Call Details Starting Grant (StG), PE7, ERC-2014-STG
Summary Interfacing with neural tissues is an important scientific goal to understand cellular processes and to combat nervous-system related diseases. Nanotechnology has a significant potential for the development of new neural interfaces. The atomic-level design and control of the nanostructures for neural interfacing can revolutionize the junction between neurons and nanomaterials. In this project, we propose a totally new approach for understanding fundamental requirements and from this knowledge designing customised nanomaterials with optimised characteristics. These will be used to develop and demonstrate unconventional neural interfaces that are ultimately designed, controlled and constructed at the nanoscale. Hence, the key objectives of this proposal are: (1) to use quantum mechanics in a new way to control and explore the neural photostimulation mechanism, (2) to explore, design and synthesize new biocompatible colloidal nanocrystals for neural photostimulation, to overcome the limitations in terms of toxic material contents (e.g., cadmium, lead, mercury, etc.), (3) to demonstrate novel biocompatible neural interfaces with exciton and quantum funnels, and plasmonic nanostructures for enhanced spectral sensitivity and dynamic range. This new approach from quantum mechanical design to nanocrystal assembly will enable exploring, tuning and controlling the underlying physical mechanisms of neural photostimulation. Furthermore, the biocompatible nanomaterials will result in a more reliable nanobiojunction. The funnel and plasmon structures will lead to unprecedented spectral sensitivities and dynamic ranges that are far beyond the state-of-the-art optoelectronic interfaces. The project is therefore expected to have high impact and may herald a new paradigm in neural interfacing. NOVELNOBI is expected to attract significant attention of researchers from diverse fields such as photonics, nanomaterials, photomedicine and neuroscience.
Summary
Interfacing with neural tissues is an important scientific goal to understand cellular processes and to combat nervous-system related diseases. Nanotechnology has a significant potential for the development of new neural interfaces. The atomic-level design and control of the nanostructures for neural interfacing can revolutionize the junction between neurons and nanomaterials. In this project, we propose a totally new approach for understanding fundamental requirements and from this knowledge designing customised nanomaterials with optimised characteristics. These will be used to develop and demonstrate unconventional neural interfaces that are ultimately designed, controlled and constructed at the nanoscale. Hence, the key objectives of this proposal are: (1) to use quantum mechanics in a new way to control and explore the neural photostimulation mechanism, (2) to explore, design and synthesize new biocompatible colloidal nanocrystals for neural photostimulation, to overcome the limitations in terms of toxic material contents (e.g., cadmium, lead, mercury, etc.), (3) to demonstrate novel biocompatible neural interfaces with exciton and quantum funnels, and plasmonic nanostructures for enhanced spectral sensitivity and dynamic range. This new approach from quantum mechanical design to nanocrystal assembly will enable exploring, tuning and controlling the underlying physical mechanisms of neural photostimulation. Furthermore, the biocompatible nanomaterials will result in a more reliable nanobiojunction. The funnel and plasmon structures will lead to unprecedented spectral sensitivities and dynamic ranges that are far beyond the state-of-the-art optoelectronic interfaces. The project is therefore expected to have high impact and may herald a new paradigm in neural interfacing. NOVELNOBI is expected to attract significant attention of researchers from diverse fields such as photonics, nanomaterials, photomedicine and neuroscience.
Max ERC Funding
1 500 000 €
Duration
Start date: 2015-07-01, End date: 2021-06-30
Project acronym Ph.D.
Project Phase map of dynamic, adaptive colloidal crystals far from equilibrium
Researcher (PI) Serim KAYACAN ILDAY
Host Institution (HI) BILKENT UNIVERSITESI ULUSAL NANOTEKNOLOJI ARASTIRMA MERKEZI - UNAM
Country Turkey
Call Details Starting Grant (StG), PE3, ERC-2019-STG
Summary We recently reported the first observation of dynamic adaptive colloidal crystals exhibiting characteristics similar to those commonly associated with living organisms: self-replication, self-healing, adaptation, competition, motility. Here, I propose to do the first experiments to clarify precisely how dynamic adaptive behavior arises far from equilibrium and how to control it. The key to both is a fundamental question at the heart of condensed matter, statistical and nonlinear physics: When far from equilibrium, in the presence of fluctuations and faced with multiple steady states with small energy differences, how does a system evolve? Specifically, my objectives are (1) to form crystals with periodic and aperiodic patterns, e.g. 2D Bravais lattices, quasicrystals, using passive identical particles, (2) to quantify their formation energies through the effective temperature of Brownian particles, (3) to identify the conditions for emergence and control of adaptive behavior. Then, I will draw a complete phase map of these dynamic adaptive colloidal crystals using fitness landscapes to characterize each pattern. I will further ask to what extent this control is extendable down to the few-nm scale, where fluctuations are even stronger and if and how these findings change when using nonidentical, in size or shape, but still passive particles. My system comprises quasi-2D-confined pure-polystyrene 500-nm spheres suspended in water. An energy flux to drive the system far from equilibrium and sustain it there is supplied by an ultrafast laser. My method exploits only three physical tenets, nonlinearity, fluctuations and positive/negative feedback mechanisms acting on identical passive particles, yet generates extremely rich emergent dynamics. A full understanding of how such dynamics arise from so few basic ingredients will advance our understanding of complex systems in addition to numerous practical applications to self-assembly, microfluidics, nanoscience and biology.
Summary
We recently reported the first observation of dynamic adaptive colloidal crystals exhibiting characteristics similar to those commonly associated with living organisms: self-replication, self-healing, adaptation, competition, motility. Here, I propose to do the first experiments to clarify precisely how dynamic adaptive behavior arises far from equilibrium and how to control it. The key to both is a fundamental question at the heart of condensed matter, statistical and nonlinear physics: When far from equilibrium, in the presence of fluctuations and faced with multiple steady states with small energy differences, how does a system evolve? Specifically, my objectives are (1) to form crystals with periodic and aperiodic patterns, e.g. 2D Bravais lattices, quasicrystals, using passive identical particles, (2) to quantify their formation energies through the effective temperature of Brownian particles, (3) to identify the conditions for emergence and control of adaptive behavior. Then, I will draw a complete phase map of these dynamic adaptive colloidal crystals using fitness landscapes to characterize each pattern. I will further ask to what extent this control is extendable down to the few-nm scale, where fluctuations are even stronger and if and how these findings change when using nonidentical, in size or shape, but still passive particles. My system comprises quasi-2D-confined pure-polystyrene 500-nm spheres suspended in water. An energy flux to drive the system far from equilibrium and sustain it there is supplied by an ultrafast laser. My method exploits only three physical tenets, nonlinearity, fluctuations and positive/negative feedback mechanisms acting on identical passive particles, yet generates extremely rich emergent dynamics. A full understanding of how such dynamics arise from so few basic ingredients will advance our understanding of complex systems in addition to numerous practical applications to self-assembly, microfluidics, nanoscience and biology.
Max ERC Funding
1 500 000 €
Duration
Start date: 2019-11-01, End date: 2024-10-31
