Project acronym ALEM
Project ADDITIONAL LOSSES IN ELECTRICAL MACHINES
Researcher (PI) Matti Antero Arkkio
Host Institution (HI) AALTO KORKEAKOULUSAATIO SR
Country Finland
Call Details Advanced Grant (AdG), PE8, ERC-2013-ADG
Summary "Electrical motors consume about 40 % of the electrical energy produced in the European Union. About 90 % of this energy is converted to mechanical work. However, 0.5-2.5 % of it goes to so called additional load losses whose exact origins are unknown. Our ambitious aim is to reveal the origins of these losses, build up numerical tools for modeling them and optimize electrical motors to minimize the losses.
As the hypothesis of the research, we assume that the additional losses mainly result from the deterioration of the core materials during the manufacturing process of the machine. By calorimetric measurements, we have found that the core losses of electrical machines may be twice as large as comprehensive loss models predict. The electrical steel sheets are punched, welded together and shrink fit to the frame. This causes residual strains in the core sheets deteriorating their magnetic characteristics. The cutting burrs make galvanic contacts between the sheets and form paths for inter-lamination currents. Another potential source of additional losses are the circulating currents between the parallel strands of random-wound armature windings. The stochastic nature of these potential sources of additional losses puts more challenge on the research.
We shall develop a physical loss model that couples the mechanical strains and electromagnetic losses in electrical steel sheets and apply the new model for comprehensive loss analysis of electrical machines. The stochastic variables related to the core losses and circulating-current losses will be discretized together with the temporal and spatial discretization of the electromechanical field variables. The numerical stochastic loss model will be used to search for such machine constructions that are insensitive to the manufacturing defects. We shall validate the new numerical loss models by electromechanical and calorimetric measurements."
Summary
"Electrical motors consume about 40 % of the electrical energy produced in the European Union. About 90 % of this energy is converted to mechanical work. However, 0.5-2.5 % of it goes to so called additional load losses whose exact origins are unknown. Our ambitious aim is to reveal the origins of these losses, build up numerical tools for modeling them and optimize electrical motors to minimize the losses.
As the hypothesis of the research, we assume that the additional losses mainly result from the deterioration of the core materials during the manufacturing process of the machine. By calorimetric measurements, we have found that the core losses of electrical machines may be twice as large as comprehensive loss models predict. The electrical steel sheets are punched, welded together and shrink fit to the frame. This causes residual strains in the core sheets deteriorating their magnetic characteristics. The cutting burrs make galvanic contacts between the sheets and form paths for inter-lamination currents. Another potential source of additional losses are the circulating currents between the parallel strands of random-wound armature windings. The stochastic nature of these potential sources of additional losses puts more challenge on the research.
We shall develop a physical loss model that couples the mechanical strains and electromagnetic losses in electrical steel sheets and apply the new model for comprehensive loss analysis of electrical machines. The stochastic variables related to the core losses and circulating-current losses will be discretized together with the temporal and spatial discretization of the electromechanical field variables. The numerical stochastic loss model will be used to search for such machine constructions that are insensitive to the manufacturing defects. We shall validate the new numerical loss models by electromechanical and calorimetric measurements."
Max ERC Funding
2 489 949 €
Duration
Start date: 2014-03-01, End date: 2019-02-28
Project acronym CAVITYQPD
Project Cavity quantum phonon dynamics
Researcher (PI) Mika Antero Sillanpaeae
Host Institution (HI) AALTO KORKEAKOULUSAATIO SR
Country Finland
Call Details Consolidator Grant (CoG), PE3, ERC-2013-CoG
Summary "Large bodies usually follow the classical equations of motion. Deviations from this can be called
macroscopic quantum behavior. These phenomena have been experimentally verified with cavity Quantum
Electro Dynamics (QED), trapped ions, and superconducting Josephson junction systems. Recently, evidence
was obtained that also moving objects can display such behavior. These objects are micromechanical
resonators (MR), which can measure tens of microns in size and are hence quite macroscopic. The degree of
freedom is their vibrations: phonons.
I propose experimental research in order to push quantum mechanics closer to the classical world than ever
before. I will try find quantum behavior in the most classical objects, that is, slowly moving bodies. I will use
MR's, accessed via electrical resonators. Part of it will be in analogy to the previously studied macroscopic
systems, but with photons replaced by phonons. The experiments are done in a cryogenic temperature mostly
in dilution refrigerator. The work will open up new perspectives on how nature works, and can have
technological implications.
The first basic setup is the coupling of MR to microwave cavity resonators. This is a direct analogy to
optomechanics, and can be called circuit optomechanics. The goals will be phonon state transfer via a cavity
bus, construction of squeezed states and of phonon-cavity entanglement. The second setup is to boost the
optomechanical coupling with a Josephson junction system, and reach the single-phonon strong-coupling for
the first time. The third setup is the coupling of MR to a Josephson junction artificial atom. Here we will
access the MR same way as the motion of a trapped ions is coupled to their internal transitions. In this setup,
I am proposing to construct exotic quantum states of motion, and finally entangle and transfer phonons over
mm-distance via cavity-coupled qubits. I believe within the project it is possible to perform rudimentary Bell
measurement with phonons."
Summary
"Large bodies usually follow the classical equations of motion. Deviations from this can be called
macroscopic quantum behavior. These phenomena have been experimentally verified with cavity Quantum
Electro Dynamics (QED), trapped ions, and superconducting Josephson junction systems. Recently, evidence
was obtained that also moving objects can display such behavior. These objects are micromechanical
resonators (MR), which can measure tens of microns in size and are hence quite macroscopic. The degree of
freedom is their vibrations: phonons.
I propose experimental research in order to push quantum mechanics closer to the classical world than ever
before. I will try find quantum behavior in the most classical objects, that is, slowly moving bodies. I will use
MR's, accessed via electrical resonators. Part of it will be in analogy to the previously studied macroscopic
systems, but with photons replaced by phonons. The experiments are done in a cryogenic temperature mostly
in dilution refrigerator. The work will open up new perspectives on how nature works, and can have
technological implications.
The first basic setup is the coupling of MR to microwave cavity resonators. This is a direct analogy to
optomechanics, and can be called circuit optomechanics. The goals will be phonon state transfer via a cavity
bus, construction of squeezed states and of phonon-cavity entanglement. The second setup is to boost the
optomechanical coupling with a Josephson junction system, and reach the single-phonon strong-coupling for
the first time. The third setup is the coupling of MR to a Josephson junction artificial atom. Here we will
access the MR same way as the motion of a trapped ions is coupled to their internal transitions. In this setup,
I am proposing to construct exotic quantum states of motion, and finally entangle and transfer phonons over
mm-distance via cavity-coupled qubits. I believe within the project it is possible to perform rudimentary Bell
measurement with phonons."
Max ERC Funding
2 004 283 €
Duration
Start date: 2015-01-01, End date: 2019-12-31
Project acronym CODE
Project Condensation in designed systems
Researcher (PI) Paeivi Elina Toermae
Host Institution (HI) AALTO KORKEAKOULUSAATIO SR
Country Finland
Call Details Advanced Grant (AdG), PE2, ERC-2013-ADG
Summary "Quantum coherent phenomena, especially marcoscopic quantum coherence, are among the most striking predictions of quantum mechanics. They have lead to remarkable applications such as lasers and modern optical technologies, and in the future, breakthroughs such as quantum information processing are envisioned. Macroscopic quantum coherence is manifested in Bose-Einstein condensation (BEC), superfluidity, and superconductivity, which have been observed in a variety of systems and continue to be at the front line of scientific research. Here my objective is to extend the realm of Bose-Einstein condensation into new conceptual and practical directions. I focus on the role of a hybrid character of the object that condenses and on the role of non-equilibrium in the BEC phenomenon. The work is mostly theoretical but has also an experimental part. I study two new types of hybrids, fundamentally different from each other. First, I consider pairing and superfluidity in a mixed geometry. Experimental realization of mixed geometries is becoming feasible in ultracold gases. Second, I explore the possibility of finding novel hybrids of light and matter excitations that may display condensation. By combining insight from these two cases, my goal is to understand how the hybrid and non-equilibrium nature can be exploited to design desirable properties, such as high critical temperatures. In particular, in case of the new light-matter hybrids, the goal is to provide realistic scenarios for, and also experimentally demonstrate, a room temperature BEC."
Summary
"Quantum coherent phenomena, especially marcoscopic quantum coherence, are among the most striking predictions of quantum mechanics. They have lead to remarkable applications such as lasers and modern optical technologies, and in the future, breakthroughs such as quantum information processing are envisioned. Macroscopic quantum coherence is manifested in Bose-Einstein condensation (BEC), superfluidity, and superconductivity, which have been observed in a variety of systems and continue to be at the front line of scientific research. Here my objective is to extend the realm of Bose-Einstein condensation into new conceptual and practical directions. I focus on the role of a hybrid character of the object that condenses and on the role of non-equilibrium in the BEC phenomenon. The work is mostly theoretical but has also an experimental part. I study two new types of hybrids, fundamentally different from each other. First, I consider pairing and superfluidity in a mixed geometry. Experimental realization of mixed geometries is becoming feasible in ultracold gases. Second, I explore the possibility of finding novel hybrids of light and matter excitations that may display condensation. By combining insight from these two cases, my goal is to understand how the hybrid and non-equilibrium nature can be exploited to design desirable properties, such as high critical temperatures. In particular, in case of the new light-matter hybrids, the goal is to provide realistic scenarios for, and also experimentally demonstrate, a room temperature BEC."
Max ERC Funding
1 559 608 €
Duration
Start date: 2013-12-01, End date: 2018-11-30
Project acronym COMPASS
Project Colloids with complex interactions: from model atoms to colloidal recognition and bio-inspired self assembly
Researcher (PI) Peter Schurtenberger
Host Institution (HI) MAX IV Laboratory, Lund University
Country Sweden
Call Details Advanced Grant (AdG), PE3, ERC-2013-ADG
Summary Self-assembly is the key construction principle that nature uses so successfully to fabricate its molecular machinery and highly elaborate structures. In this project we will follow nature’s strategies and make a concerted experimental and theoretical effort to study, understand and control self-assembly for a new generation of colloidal building blocks. Starting point will be recent advances in colloid synthesis strategies that have led to a spectacular array of colloids of different shapes, compositions, patterns and functionalities. These allow us to investigate the influence of anisotropy in shape and interactions on aggregation and self-assembly in colloidal suspensions and mixtures. Using responsive particles we will implement colloidal lock-and-key mechanisms and then assemble a library of “colloidal molecules” with well-defined and externally tunable binding sites using microfluidics-based and externally controlled fabrication and sorting principles. We will use them to explore the equilibrium phase behavior of particle systems interacting through a finite number of binding sites. In parallel, we will exploit them and investigate colloid self-assembly into well-defined nanostructures. Here we aim at achieving much more refined control than currently possible by implementing a protein-inspired approach to controlled self-assembly. We combine molecule-like colloidal building blocks that possess directional interactions and externally triggerable specific recognition sites with directed self-assembly where external fields not only facilitate assembly, but also allow fabricating novel structures. We will use the tunable combination of different contributions to the interaction potential between the colloidal building blocks and the ability to create chirality in the assembly to establish the requirements for the controlled formation of tubular shells and thus create a colloid-based minimal model of synthetic virus capsid proteins.
Summary
Self-assembly is the key construction principle that nature uses so successfully to fabricate its molecular machinery and highly elaborate structures. In this project we will follow nature’s strategies and make a concerted experimental and theoretical effort to study, understand and control self-assembly for a new generation of colloidal building blocks. Starting point will be recent advances in colloid synthesis strategies that have led to a spectacular array of colloids of different shapes, compositions, patterns and functionalities. These allow us to investigate the influence of anisotropy in shape and interactions on aggregation and self-assembly in colloidal suspensions and mixtures. Using responsive particles we will implement colloidal lock-and-key mechanisms and then assemble a library of “colloidal molecules” with well-defined and externally tunable binding sites using microfluidics-based and externally controlled fabrication and sorting principles. We will use them to explore the equilibrium phase behavior of particle systems interacting through a finite number of binding sites. In parallel, we will exploit them and investigate colloid self-assembly into well-defined nanostructures. Here we aim at achieving much more refined control than currently possible by implementing a protein-inspired approach to controlled self-assembly. We combine molecule-like colloidal building blocks that possess directional interactions and externally triggerable specific recognition sites with directed self-assembly where external fields not only facilitate assembly, but also allow fabricating novel structures. We will use the tunable combination of different contributions to the interaction potential between the colloidal building blocks and the ability to create chirality in the assembly to establish the requirements for the controlled formation of tubular shells and thus create a colloid-based minimal model of synthetic virus capsid proteins.
Max ERC Funding
2 498 040 €
Duration
Start date: 2014-02-01, End date: 2019-01-31
Project acronym CrowdLand
Project Harnessing the power of crowdsourcing to improve land cover and land-use information
Researcher (PI) Steffen Martin Fritz
Host Institution (HI) INTERNATIONALES INSTITUT FUER ANGEWANDTE SYSTEMANALYSE
Country Austria
Call Details Consolidator Grant (CoG), SH3, ERC-2013-CoG
Summary Information about land cover, land use and the change over time is used for a wide range of applications such as nature protection and biodiversity, forest and water management, urban and transport planning, natural hazard prevention and mitigation, agricultural policies and monitoring climate change. Furthermore, high quality spatially explicit information on land cover change is an essential input variable to land use change modelling, which is increasingly being used to better understand the potential impact of certain policies. The amount of observed land cover change also serves as an important indicator of how well different regional, national and European policies have been implemented.
However, outside Europe and outside the developed world in particular, information on land cover and land cover change in poorer countries is hardly available and no national or regional dense sample based monitoring approaches such as LUCAS exists which deliver sufficiently accurate land cover and land cover change information. Moreover in particular in developing countries, there is no or very little information on land-use and crop management. Only very limited data available from FAO and an incomplete coverage of sub-national statistics (e.g. IFPRI) are available.
This research project will assess the potential of using crowdsourcing to close these big data gaps in developing and developed countries with a number of case studies and different data collection methods. The CrowdLand project will be carried out in two very different environments, i.e. Austria and Kenya.The overall research objectives of this project are to 1) test the potential of using social gaming to collect land use information 2) test the potential of using mobile money to collect data in developing countries 3) understand the data quality collected via crowdsourcing 4) apply advanced methods to filter crowdsourced data in order to attain improved accuracy.
Summary
Information about land cover, land use and the change over time is used for a wide range of applications such as nature protection and biodiversity, forest and water management, urban and transport planning, natural hazard prevention and mitigation, agricultural policies and monitoring climate change. Furthermore, high quality spatially explicit information on land cover change is an essential input variable to land use change modelling, which is increasingly being used to better understand the potential impact of certain policies. The amount of observed land cover change also serves as an important indicator of how well different regional, national and European policies have been implemented.
However, outside Europe and outside the developed world in particular, information on land cover and land cover change in poorer countries is hardly available and no national or regional dense sample based monitoring approaches such as LUCAS exists which deliver sufficiently accurate land cover and land cover change information. Moreover in particular in developing countries, there is no or very little information on land-use and crop management. Only very limited data available from FAO and an incomplete coverage of sub-national statistics (e.g. IFPRI) are available.
This research project will assess the potential of using crowdsourcing to close these big data gaps in developing and developed countries with a number of case studies and different data collection methods. The CrowdLand project will be carried out in two very different environments, i.e. Austria and Kenya.The overall research objectives of this project are to 1) test the potential of using social gaming to collect land use information 2) test the potential of using mobile money to collect data in developing countries 3) understand the data quality collected via crowdsourcing 4) apply advanced methods to filter crowdsourced data in order to attain improved accuracy.
Max ERC Funding
1 397 200 €
Duration
Start date: 2014-04-01, End date: 2020-03-31
Project acronym DOiCV
Project Discrete Optimization in Computer Vision: Theory and Practice
Researcher (PI) Vladimir Kolmogorov
Host Institution (HI) INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA
Country Austria
Call Details Consolidator Grant (CoG), PE6, ERC-2013-CoG
Summary This proposal aims at developing new inference algorithms for graphical models with discrete variables, with a focus on the MAP estimation task. MAP estimation algorithms such as graph cuts have transformed computer vision in the last decade; they are now routinely used and are also utilized in commercial systems.
Topics of this project fall into 3 categories.
Theoretically-oriented: Graph cut techniques come from combinatorial optimization. They can minimize a certain class of functions, namely submodular functions with unary and pairwise terms. Larger classes of functions can be minimized in polynomial time. A complete characterization of such classes has been established. They include k-submodular functions for an integer k _ 1.
I investigate whether such tools from discrete optimization can lead to more efficient inference algorithms for practical problems. I have already found an important application of k-submodular functions for minimizing Potts energy functions that are frequently used in computer vision. The concept of submodularity also recently appeared in the context of the task of computing marginals in graphical models, here discrete optimization tools could be used.
Practically-oriented: Modern techniques such as graph cuts and tree-reweighted message passing give excellent results for some graphical models such as with the Potts energies. However, they fail for more complicated models. I aim to develop new tools for tackling such hard energies. This will include exploring tighter convex relaxations of the problem.
Applications, sequence tagging problems: Recently, we developed new algorithms for inference in pattern-based Conditional Random Fields (CRFs) on a chain. This model can naturally be applied to sequence tagging problems; it generalizes the popular CRF model by giving it more flexibility. I will investigate (i) applications to specific tasks, such as the protein secondary structure prediction, and (ii) ways to extend the model.
Summary
This proposal aims at developing new inference algorithms for graphical models with discrete variables, with a focus on the MAP estimation task. MAP estimation algorithms such as graph cuts have transformed computer vision in the last decade; they are now routinely used and are also utilized in commercial systems.
Topics of this project fall into 3 categories.
Theoretically-oriented: Graph cut techniques come from combinatorial optimization. They can minimize a certain class of functions, namely submodular functions with unary and pairwise terms. Larger classes of functions can be minimized in polynomial time. A complete characterization of such classes has been established. They include k-submodular functions for an integer k _ 1.
I investigate whether such tools from discrete optimization can lead to more efficient inference algorithms for practical problems. I have already found an important application of k-submodular functions for minimizing Potts energy functions that are frequently used in computer vision. The concept of submodularity also recently appeared in the context of the task of computing marginals in graphical models, here discrete optimization tools could be used.
Practically-oriented: Modern techniques such as graph cuts and tree-reweighted message passing give excellent results for some graphical models such as with the Potts energies. However, they fail for more complicated models. I aim to develop new tools for tackling such hard energies. This will include exploring tighter convex relaxations of the problem.
Applications, sequence tagging problems: Recently, we developed new algorithms for inference in pattern-based Conditional Random Fields (CRFs) on a chain. This model can naturally be applied to sequence tagging problems; it generalizes the popular CRF model by giving it more flexibility. I will investigate (i) applications to specific tasks, such as the protein secondary structure prediction, and (ii) ways to extend the model.
Max ERC Funding
1 641 585 €
Duration
Start date: 2014-06-01, End date: 2019-05-31
Project acronym GRAPHALGAPP
Project Challenges in Graph Algorithms with Applications
Researcher (PI) Monika Hildegard Henzinger
Host Institution (HI) UNIVERSITAT WIEN
Country Austria
Call Details Advanced Grant (AdG), PE6, ERC-2013-ADG
Summary This project has two thrusts of equal importance. Firstly, it aims to develop new graph algorithmic techniques, specifically in the areas of dynamic graph algorithms, online algorithms and approximation algorithms for graph-based optimization problems. Thus, it proposes to solve long-standing, fundamental problems that are central to the field of algorithms. Secondly, it plans to apply these techniques to graph algorithmic problems in different fields of application, specifically in computer-aided verification, computational biology, and web-based advertisement with the goal of significantly advancing the state-of-the-art in these fields. This includes theoretical work as well as experimental evaluation on real-life data sets.
Thus, the goal of this project is a comprehensive approach to algorithms research which involves both excellent fundamental algorithms research as well as solving concrete applications.
Summary
This project has two thrusts of equal importance. Firstly, it aims to develop new graph algorithmic techniques, specifically in the areas of dynamic graph algorithms, online algorithms and approximation algorithms for graph-based optimization problems. Thus, it proposes to solve long-standing, fundamental problems that are central to the field of algorithms. Secondly, it plans to apply these techniques to graph algorithmic problems in different fields of application, specifically in computer-aided verification, computational biology, and web-based advertisement with the goal of significantly advancing the state-of-the-art in these fields. This includes theoretical work as well as experimental evaluation on real-life data sets.
Thus, the goal of this project is a comprehensive approach to algorithms research which involves both excellent fundamental algorithms research as well as solving concrete applications.
Max ERC Funding
2 428 258 €
Duration
Start date: 2014-03-01, End date: 2019-08-31
Project acronym HYDROCARB
Project Towards a new understanding of carbon processing in freshwaters: methane emission hot spots and carbon burial
Researcher (PI) Sebastian Sobek
Host Institution (HI) UPPSALA UNIVERSITET
Country Sweden
Call Details Starting Grant (StG), PE10, ERC-2013-StG
Summary In spite of their small areal extent, inland waters play a vital role in the carbon cycle of the continents, as they emit significant amounts of the greenhouse gases (GHG) carbon dioxide (CO2) and methane (CH4) to the atmosphere, and simultaneously bury more organic carbon (OC) in their sediments than the entire ocean. Particularly in tropical hydropower reservoirs, GHG emissions can be large, mainly owing to high CH4 emission. Moreover, the number of tropical hydropower reservoirs will continue to increase dramatically, due to an urgent need for economic growth and a vast unused hydropower potential in many tropical countries. However, the current understanding of the magnitude of GHG emission, and of the processes regulating it, is insufficient. Here I propose a research program on tropical reservoirs in Brazil that takes advantage of recent developments in both concepts and methodologies to provide unique evaluations of GHG emission and OC burial in tropical reservoirs. In particular, I will test the following hypotheses: 1) Current estimates of reservoir CH4 emission are at least one order of magnitude too low, since they have completely missed the recently discovered existence of gas bubble emission hot spots; 2) The burial of land-derived OC in reservoir sediments offsets a significant share of the GHG emissions; and 3) The sustained, long-term CH4 emission from reservoirs is to a large degree fuelled by primary production of new OC within the reservoir, and may therefore be reduced by management of nutrient supply. The new understanding and the cross-disciplinary methodological approach will constitute a major advance to aquatic science in general, and have strong impacts on the understanding of other aquatic systems at other latitudes as well. In addition, the results will be merged into an existing reservoir GHG risk assessment tool to improve planning, design, management and judgment of hydropower reservoirs.
Summary
In spite of their small areal extent, inland waters play a vital role in the carbon cycle of the continents, as they emit significant amounts of the greenhouse gases (GHG) carbon dioxide (CO2) and methane (CH4) to the atmosphere, and simultaneously bury more organic carbon (OC) in their sediments than the entire ocean. Particularly in tropical hydropower reservoirs, GHG emissions can be large, mainly owing to high CH4 emission. Moreover, the number of tropical hydropower reservoirs will continue to increase dramatically, due to an urgent need for economic growth and a vast unused hydropower potential in many tropical countries. However, the current understanding of the magnitude of GHG emission, and of the processes regulating it, is insufficient. Here I propose a research program on tropical reservoirs in Brazil that takes advantage of recent developments in both concepts and methodologies to provide unique evaluations of GHG emission and OC burial in tropical reservoirs. In particular, I will test the following hypotheses: 1) Current estimates of reservoir CH4 emission are at least one order of magnitude too low, since they have completely missed the recently discovered existence of gas bubble emission hot spots; 2) The burial of land-derived OC in reservoir sediments offsets a significant share of the GHG emissions; and 3) The sustained, long-term CH4 emission from reservoirs is to a large degree fuelled by primary production of new OC within the reservoir, and may therefore be reduced by management of nutrient supply. The new understanding and the cross-disciplinary methodological approach will constitute a major advance to aquatic science in general, and have strong impacts on the understanding of other aquatic systems at other latitudes as well. In addition, the results will be merged into an existing reservoir GHG risk assessment tool to improve planning, design, management and judgment of hydropower reservoirs.
Max ERC Funding
1 798 227 €
Duration
Start date: 2013-09-01, End date: 2019-08-31
Project acronym IgYPurTech
Project IgY Technology: A Purification Platform using Ionic-Liquid-Based Aqueous Biphasic Systems
Researcher (PI) Mara Guadalupe Freire Martins
Host Institution (HI) UNIVERSIDADE DE AVEIRO
Country Portugal
Call Details Starting Grant (StG), PE8, ERC-2013-StG
Summary With the emergence of antibiotic-resistant pathogens the development of antigen-specific antibodies for use in passive immunotherapy is, nowadays, a major concern in human society. Despite the most focused mammal antibodies, antibodies obtained from egg yolk of immunized hens, immunoglobulin Y (IgY), are an alternative option that can be obtained in higher titres by non-stressful and non-invasive methods. This large amount of available antibodies opens the door for a new kind of cheaper biopharmaceuticals. However, the production cost of high-quality IgY for large-scale applications remains higher than other drug therapies due to the lack of an efficient purification method. The search of new purification platforms is thus a vital demand to which liquid-liquid extraction using aqueous biphasic systems (ABS) could be the answer. Besides the conventional polymer-based systems, highly viscous and with a limited polarity/affinity range, a recent type of ABS composed of ionic liquids (ILs) may be employed. ILs are usually classified as “green solvents” due to their negligible vapour pressure. Yet, the major advantage of IL-based ABS relies on the possibility of tailoring their phases’ polarities aiming at extracting a target biomolecule. A proper manipulation of the system constituents and respective composition allows the pre-concentration, complete extraction, or purification of the most diverse biomolecules.
This research project addresses the development of a new technique for the extraction and purification of IgY from egg yolk using IL-based ABS. The proposed plan contemplates the optimization of purification systems at the laboratory scale and their use in countercurrent chromatography to achieve a simple, cost-effective and scalable process. The success of this project and its scalability to an industrial level certainly will allow the production of cheaper antibodies with a long-term impact in human healthcare.
Summary
With the emergence of antibiotic-resistant pathogens the development of antigen-specific antibodies for use in passive immunotherapy is, nowadays, a major concern in human society. Despite the most focused mammal antibodies, antibodies obtained from egg yolk of immunized hens, immunoglobulin Y (IgY), are an alternative option that can be obtained in higher titres by non-stressful and non-invasive methods. This large amount of available antibodies opens the door for a new kind of cheaper biopharmaceuticals. However, the production cost of high-quality IgY for large-scale applications remains higher than other drug therapies due to the lack of an efficient purification method. The search of new purification platforms is thus a vital demand to which liquid-liquid extraction using aqueous biphasic systems (ABS) could be the answer. Besides the conventional polymer-based systems, highly viscous and with a limited polarity/affinity range, a recent type of ABS composed of ionic liquids (ILs) may be employed. ILs are usually classified as “green solvents” due to their negligible vapour pressure. Yet, the major advantage of IL-based ABS relies on the possibility of tailoring their phases’ polarities aiming at extracting a target biomolecule. A proper manipulation of the system constituents and respective composition allows the pre-concentration, complete extraction, or purification of the most diverse biomolecules.
This research project addresses the development of a new technique for the extraction and purification of IgY from egg yolk using IL-based ABS. The proposed plan contemplates the optimization of purification systems at the laboratory scale and their use in countercurrent chromatography to achieve a simple, cost-effective and scalable process. The success of this project and its scalability to an industrial level certainly will allow the production of cheaper antibodies with a long-term impact in human healthcare.
Max ERC Funding
1 386 020 €
Duration
Start date: 2014-02-01, End date: 2019-01-31
Project acronym INTEGRAL
Project Integrable Systems in Gauge and String Theory
Researcher (PI) Konstantin Zarembo
Host Institution (HI) STOCKHOLMS UNIVERSITET
Country Sweden
Call Details Advanced Grant (AdG), PE2, ERC-2013-ADG
Summary The project is aimed at uncovering new links between integrable systems, string theory and quantum field theory. The goal is to study non-perturbative phenomena in strongly-coupled field theories, and to understand relationship between gauge fields and strings at a deeper level.
Summary
The project is aimed at uncovering new links between integrable systems, string theory and quantum field theory. The goal is to study non-perturbative phenomena in strongly-coupled field theories, and to understand relationship between gauge fields and strings at a deeper level.
Max ERC Funding
1 693 692 €
Duration
Start date: 2014-03-01, End date: 2019-02-28