Project acronym DEVOCEAN
Project Impact of diatom evolution on the oceans
Researcher (PI) Daniel CONLEY
Host Institution (HI) LUNDS UNIVERSITET
Country Sweden
Call Details Advanced Grant (AdG), PE10, ERC-2018-ADG
Summary Motivated by a series of recent discoveries, DEVOCEAN will provide the first comprehensive evaluation of the emergence of diatoms and their impact on the global biogeochemical cycle of silica, carbon and other nutrients that regulate ocean productivity and ultimately climate. I propose that the proliferation of phytoplankton that occurred after the Permian-Triassic extinction, in particular the diatoms, fundamentally influenced oceanic environments through the enhancement of carbon export to depth as part of the biological pump. Although molecular clocks suggest that diatoms evolved over 200 Ma ago, this result has been largely ignored because of the lack of diatoms in the geologic fossil record with most studies therefore focused on diversification during the Cenozoic where abundant diatom fossils are found. Much of the older fossil evidence has likely been destroyed by dissolution during diagenesis, subducted or is concealed deep within the Earth under many layers of rock. DEVOCEAN will provide evidence on diatom evolution and speciation in the geological record by examining formations representing locations in which diatoms are likely to have accumulated in ocean sediments. We will generate robust estimates of the timing and magnitude of dissolved Si drawdown following the origin of diatoms using the isotopic silicon composition of fossil sponge spicules and radiolarians. The project will also provide fundamental new insights into the timing of dissolved Si drawdown and other key events, which reorganized the distribution of carbon and nutrients in seawater, changing energy flows and productivity in the biological communities of the ancient oceans.
Summary
Motivated by a series of recent discoveries, DEVOCEAN will provide the first comprehensive evaluation of the emergence of diatoms and their impact on the global biogeochemical cycle of silica, carbon and other nutrients that regulate ocean productivity and ultimately climate. I propose that the proliferation of phytoplankton that occurred after the Permian-Triassic extinction, in particular the diatoms, fundamentally influenced oceanic environments through the enhancement of carbon export to depth as part of the biological pump. Although molecular clocks suggest that diatoms evolved over 200 Ma ago, this result has been largely ignored because of the lack of diatoms in the geologic fossil record with most studies therefore focused on diversification during the Cenozoic where abundant diatom fossils are found. Much of the older fossil evidence has likely been destroyed by dissolution during diagenesis, subducted or is concealed deep within the Earth under many layers of rock. DEVOCEAN will provide evidence on diatom evolution and speciation in the geological record by examining formations representing locations in which diatoms are likely to have accumulated in ocean sediments. We will generate robust estimates of the timing and magnitude of dissolved Si drawdown following the origin of diatoms using the isotopic silicon composition of fossil sponge spicules and radiolarians. The project will also provide fundamental new insights into the timing of dissolved Si drawdown and other key events, which reorganized the distribution of carbon and nutrients in seawater, changing energy flows and productivity in the biological communities of the ancient oceans.
Max ERC Funding
2 500 000 €
Duration
Start date: 2019-10-01, End date: 2024-09-30
Project acronym e-NeuroPharma
Project Electronic Neuropharmacology
Researcher (PI) Rolf Magnus BERGGREN
Host Institution (HI) LINKOPINGS UNIVERSITET
Country Sweden
Call Details Advanced Grant (AdG), PE5, ERC-2018-ADG
Summary As the population ages, neurodegenerative diseases (ND) will have a devastating impact on individuals and society. Despite enormous research efforts there is still no cure for these diseases, only care! The origin of ND is hugely complex, spanning from the molecular level to systemic processes, causing malfunctioning of signalling in the central nervous system (CNS). This signalling includes the coupled processing of biochemical and electrical signals, however current approaches for symptomatic- and disease modifying treatments are all based on biochemical approaches, alone.
Organic bioelectronics has arisen as a promising technology providing signal translation, as sensors and modulators, across the biology-technology interface; especially, it has proven unique in neuronal applications. There is great opportunity with organic bioelectronics since it can complement biochemical pharmacology to enable a twinned electric-biochemical therapy for ND and neurological disorders. However, this technology is traditionally manufactured on stand-alone substrates. Even though organic bioelectronics has been manufactured on flexible and soft carriers in the past, current technology consume space and volume, that when applied to CNS, rule out close proximity and amalgamation between the bioelectronics technology and CNS components – features that are needed in order to reach high therapeutic efficacy.
e-NeuroPharma includes development of innovative organic bioelectronics, that can be in-vivo-manufactured within the brain. The overall aim is to evaluate and develop electrodes, delivery devices and sensors that enable a twinned biochemical-electric therapy approach to combat ND and other neurological disorders. e-NeuroPharma will focus on the development of materials that can cross the blood-brain-barrier, that self-organize and -polymerize along CNS components, and that record and regulate relevant electrical, electrochemical and physical parameters relevant to ND and disorders
Summary
As the population ages, neurodegenerative diseases (ND) will have a devastating impact on individuals and society. Despite enormous research efforts there is still no cure for these diseases, only care! The origin of ND is hugely complex, spanning from the molecular level to systemic processes, causing malfunctioning of signalling in the central nervous system (CNS). This signalling includes the coupled processing of biochemical and electrical signals, however current approaches for symptomatic- and disease modifying treatments are all based on biochemical approaches, alone.
Organic bioelectronics has arisen as a promising technology providing signal translation, as sensors and modulators, across the biology-technology interface; especially, it has proven unique in neuronal applications. There is great opportunity with organic bioelectronics since it can complement biochemical pharmacology to enable a twinned electric-biochemical therapy for ND and neurological disorders. However, this technology is traditionally manufactured on stand-alone substrates. Even though organic bioelectronics has been manufactured on flexible and soft carriers in the past, current technology consume space and volume, that when applied to CNS, rule out close proximity and amalgamation between the bioelectronics technology and CNS components – features that are needed in order to reach high therapeutic efficacy.
e-NeuroPharma includes development of innovative organic bioelectronics, that can be in-vivo-manufactured within the brain. The overall aim is to evaluate and develop electrodes, delivery devices and sensors that enable a twinned biochemical-electric therapy approach to combat ND and other neurological disorders. e-NeuroPharma will focus on the development of materials that can cross the blood-brain-barrier, that self-organize and -polymerize along CNS components, and that record and regulate relevant electrical, electrochemical and physical parameters relevant to ND and disorders
Max ERC Funding
3 237 335 €
Duration
Start date: 2019-09-01, End date: 2024-08-31
Project acronym GLOBEGOV
Project The Rise of Global Environmental Governance:A History of the Contemporary Human-Earth Relationship
Researcher (PI) Sverker SoeRLIN
Host Institution (HI) KUNGLIGA TEKNISKA HOEGSKOLAN
Country Sweden
Call Details Advanced Grant (AdG), SH6, ERC-2017-ADG
Summary GLOBEGOVE is a historical study of humanity’s relation to planetary conditions and constraints and how it has become understood as a governance issue. The key argument is that Global Environmental Governance (GEG), which has arisen in response to this issue, is inseparable from the rise of a planetary Earth systems science and a knowledge-informed understanding of global change that has affected broad communities of practice. The overarching objective is to provide a fundamentally new perspective on GEG that challenges both previous linear, progressivist narratives through incremental institutional work and the way contemporary history is written and understood.
GLOBEGOVE will be implemented as an expressly global history along four Trajectories, which will ensure both transnational as well as transdisciplinary analysis of GEG as a major contemporary phenomenon.
Trajectory I: Formation articulates a proto-history of GEG after 1945 when the concept of ‘the environment’ in its new integrative meaning was established and a slow formation of policy ideas and institutions could start.
Trajectory II: The complicated turning of environmental research into governance investigates the relation between environmental science and environmental governance which GLOBEGOV examines as an open ended historical process. Why was it that high politics and diplomacy came in closer relations with environmental sciences?
Trajectory III: Alternative agencies – governance through business and civic society explores corporate responses, including self-regulation through the concept of Corporate Social Responsibility, to growing concerns about environmental degradation and pollution, and business-science relations.
Trajectory IV: Integrating Earth into History – scaling, mediating, remembering will turn to historiography itself and examine how concepts and ideas from the rising Earth system sciences have been influencing both GEG and the way we think historically about Earth and humanity.
Summary
GLOBEGOVE is a historical study of humanity’s relation to planetary conditions and constraints and how it has become understood as a governance issue. The key argument is that Global Environmental Governance (GEG), which has arisen in response to this issue, is inseparable from the rise of a planetary Earth systems science and a knowledge-informed understanding of global change that has affected broad communities of practice. The overarching objective is to provide a fundamentally new perspective on GEG that challenges both previous linear, progressivist narratives through incremental institutional work and the way contemporary history is written and understood.
GLOBEGOVE will be implemented as an expressly global history along four Trajectories, which will ensure both transnational as well as transdisciplinary analysis of GEG as a major contemporary phenomenon.
Trajectory I: Formation articulates a proto-history of GEG after 1945 when the concept of ‘the environment’ in its new integrative meaning was established and a slow formation of policy ideas and institutions could start.
Trajectory II: The complicated turning of environmental research into governance investigates the relation between environmental science and environmental governance which GLOBEGOV examines as an open ended historical process. Why was it that high politics and diplomacy came in closer relations with environmental sciences?
Trajectory III: Alternative agencies – governance through business and civic society explores corporate responses, including self-regulation through the concept of Corporate Social Responsibility, to growing concerns about environmental degradation and pollution, and business-science relations.
Trajectory IV: Integrating Earth into History – scaling, mediating, remembering will turn to historiography itself and examine how concepts and ideas from the rising Earth system sciences have been influencing both GEG and the way we think historically about Earth and humanity.
Max ERC Funding
2 500 000 €
Duration
Start date: 2018-10-01, End date: 2023-09-30
Project acronym GRINDOOR
Project Green Nanotechnology for the Indoor Environment
Researcher (PI) Claes-Goeran Sture Granqvist
Host Institution (HI) UPPSALA UNIVERSITET
Country Sweden
Call Details Advanced Grant (AdG), PE5, ERC-2010-AdG_20100224
Summary The GRINDOOR project aims at developing and implementing new materials that enable huge energy savings in buildings and improve the quality of the indoor environment. About 40% of the primary energy, and 70% of the electricity, is used in buildings, and therefore the outcome of this project can have an impact on the long-term energy demand in the EU and the World. It is a highly focused study on new nanomaterials based on some transition metal oxides, which are used for four interrelated applications related to indoor lighting and indoor air: (i) electrochromic coatings are integrated in devices and used in “smart windows” to regulate the inflow of visible light and solar energy in order to minimize air condition and create indoor comfort, (ii) thermochromic nanoparticulate coatings are used on windows to provide large temperature-dependent control of the inflow of infrared solar radiation (in stand-alone cases as well as in conjunction with electrochromics), (iii) oxide-based gas sensors are used to measure indoor air quality especially with regard to formaldehyde, and (iv) photocatalytic coatings are used for indoor air cleaning. The investigated materials have many things in common and a joint and focused study, such as the one proposed here, will generate important new knowledge that can be transferred between the various sub-projects. The new oxide materials are prepared by advanced reactive gas deposition—using unique equipment—and high-pressure reactive dc magnetron sputtering. The materials are characterized and investigated by a wide range of state-of-the-art techniques.
Summary
The GRINDOOR project aims at developing and implementing new materials that enable huge energy savings in buildings and improve the quality of the indoor environment. About 40% of the primary energy, and 70% of the electricity, is used in buildings, and therefore the outcome of this project can have an impact on the long-term energy demand in the EU and the World. It is a highly focused study on new nanomaterials based on some transition metal oxides, which are used for four interrelated applications related to indoor lighting and indoor air: (i) electrochromic coatings are integrated in devices and used in “smart windows” to regulate the inflow of visible light and solar energy in order to minimize air condition and create indoor comfort, (ii) thermochromic nanoparticulate coatings are used on windows to provide large temperature-dependent control of the inflow of infrared solar radiation (in stand-alone cases as well as in conjunction with electrochromics), (iii) oxide-based gas sensors are used to measure indoor air quality especially with regard to formaldehyde, and (iv) photocatalytic coatings are used for indoor air cleaning. The investigated materials have many things in common and a joint and focused study, such as the one proposed here, will generate important new knowledge that can be transferred between the various sub-projects. The new oxide materials are prepared by advanced reactive gas deposition—using unique equipment—and high-pressure reactive dc magnetron sputtering. The materials are characterized and investigated by a wide range of state-of-the-art techniques.
Max ERC Funding
2 328 726 €
Duration
Start date: 2011-06-01, End date: 2016-05-31
Project acronym LEARN
Project Limitations, Estimation, Adaptivity, Reinforcement and Networks in System Identification
Researcher (PI) Lennart Ljung
Host Institution (HI) LINKOPINGS UNIVERSITET
Country Sweden
Call Details Advanced Grant (AdG), PE7, ERC-2010-AdG_20100224
Summary The objective with this proposal is to provide design tools and algorithms for model management in robust, adaptive and autonomous engineering systems. The increasing demands on reliable models for systems of ever greater complexity have pointed to several insufficiencies in today's techniques for model construction. The proposal addresses key areas where new ideas are required. Modeling a central issue in many scientific fields. System Identification is the term used in the Automatic Control Community for the area of building mathematical models of dynamical systems from observed input and output signals, but several other research communities work with the same problem under different names, such as (data-driven) learning.
We have identified five specific themes where progress is both acutely needed and feasible:
1. Encounters with Convex Programming Techniques: How to capitalize on the remarkable recent progress in convex and semidefinite programming to obtain efficient, robust and reliable algorithmic solutions.
2. Fundamental Limitations: To develop and elucidate what are the limits of model accuracy, regardless of the modeling method. This can be seen as a theory rooted in the Cramer-Rao inequality in the spirit of invariance results and lower bounds characterizing, e.g., Information Theory.
3. Experiment Design and Reinforcement Techniques: Study how well tailored and ``cheap'' experiments can extract essential information about isolated model properties. Also study how such methods may relate to general reinforcement techniques.
4. Potentials of Non-parametric Models: How to incorporate and adjust techniques from adjacent research communities, e.g. concerning manifold learning and Gaussian Processes in machine learning.
5. Managing Structural Constraints: To develop structure preserving identification methods for networked and decentralized systems.
We have ideas how to approach each of these themes, and initial attempts are promising.
Summary
The objective with this proposal is to provide design tools and algorithms for model management in robust, adaptive and autonomous engineering systems. The increasing demands on reliable models for systems of ever greater complexity have pointed to several insufficiencies in today's techniques for model construction. The proposal addresses key areas where new ideas are required. Modeling a central issue in many scientific fields. System Identification is the term used in the Automatic Control Community for the area of building mathematical models of dynamical systems from observed input and output signals, but several other research communities work with the same problem under different names, such as (data-driven) learning.
We have identified five specific themes where progress is both acutely needed and feasible:
1. Encounters with Convex Programming Techniques: How to capitalize on the remarkable recent progress in convex and semidefinite programming to obtain efficient, robust and reliable algorithmic solutions.
2. Fundamental Limitations: To develop and elucidate what are the limits of model accuracy, regardless of the modeling method. This can be seen as a theory rooted in the Cramer-Rao inequality in the spirit of invariance results and lower bounds characterizing, e.g., Information Theory.
3. Experiment Design and Reinforcement Techniques: Study how well tailored and ``cheap'' experiments can extract essential information about isolated model properties. Also study how such methods may relate to general reinforcement techniques.
4. Potentials of Non-parametric Models: How to incorporate and adjust techniques from adjacent research communities, e.g. concerning manifold learning and Gaussian Processes in machine learning.
5. Managing Structural Constraints: To develop structure preserving identification methods for networked and decentralized systems.
We have ideas how to approach each of these themes, and initial attempts are promising.
Max ERC Funding
2 500 000 €
Duration
Start date: 2011-01-01, End date: 2015-12-31
Project acronym OXLEET
Project Oxidation via low-energy electron transfer. Development of green oxidation methodology via a biomimetic approach
Researcher (PI) Jan Erling Baeckvall
Host Institution (HI) STOCKHOLMS UNIVERSITET
Country Sweden
Call Details Advanced Grant (AdG), PE5, ERC-2009-AdG
Summary Oxidation reactions are of fundamental importance in Nature and are key transformation in organic synthesis. There is currently a need from society to replace waste-producing expensive oxidants by environmentally benign oxidants in industrial oxidation reactions. The aim with the proposed research is to develop novel green oxidation methodology that also involves hydrogen transfer reactions. In the oxidation reactions the goal is to use molecular oxygen (air) or hydrogen peroxide as the oxidants. In the present project new catalytic oxidations via low-energy electron transfer will be developed. The catalytic reactions obtained can be used for racemization of alcohols and amines and for oxygen- and hydrogen peroxide-driven oxidations of various substrates. Examples of some reactions that will be studied are oxidative palladium-catalyzed C-C bond formation and metal-catalyzed C-H oxidation including dehydrogenation reactions with iron and ruthenium. Coupled catalytic systems where electron transfer mediators (ETMs) facilitate electron transfer from the reduced catalyst to molecular oxygen (hydrogen peroxide) will be studied. Highly efficient reoxidation systems will be designed by covalently linking two electron transfer mediators (ETMs). The intramolecular electron transfer in these hybrid ETM catalysts will significantly increase the rate of oxidation reactions. The research will lead to development of more efficient reoxidation systems based on molecular oxygen and hydrogen peroxide, as well as more versatile racemization catalysts for alcohols and amines.
Summary
Oxidation reactions are of fundamental importance in Nature and are key transformation in organic synthesis. There is currently a need from society to replace waste-producing expensive oxidants by environmentally benign oxidants in industrial oxidation reactions. The aim with the proposed research is to develop novel green oxidation methodology that also involves hydrogen transfer reactions. In the oxidation reactions the goal is to use molecular oxygen (air) or hydrogen peroxide as the oxidants. In the present project new catalytic oxidations via low-energy electron transfer will be developed. The catalytic reactions obtained can be used for racemization of alcohols and amines and for oxygen- and hydrogen peroxide-driven oxidations of various substrates. Examples of some reactions that will be studied are oxidative palladium-catalyzed C-C bond formation and metal-catalyzed C-H oxidation including dehydrogenation reactions with iron and ruthenium. Coupled catalytic systems where electron transfer mediators (ETMs) facilitate electron transfer from the reduced catalyst to molecular oxygen (hydrogen peroxide) will be studied. Highly efficient reoxidation systems will be designed by covalently linking two electron transfer mediators (ETMs). The intramolecular electron transfer in these hybrid ETM catalysts will significantly increase the rate of oxidation reactions. The research will lead to development of more efficient reoxidation systems based on molecular oxygen and hydrogen peroxide, as well as more versatile racemization catalysts for alcohols and amines.
Max ERC Funding
1 722 000 €
Duration
Start date: 2010-01-01, End date: 2015-12-31
Project acronym ScalableControl
Project Scalable Control of Interconnected Systems
Researcher (PI) Anders RANTZER
Host Institution (HI) LUNDS UNIVERSITET
Country Sweden
Call Details Advanced Grant (AdG), PE7, ERC-2018-ADG
Summary Modern society is critically dependent on large-scale networks for services such as energy supply, transportation and communications. The design and control of such networks is becoming increasingly complex, due to their growing size, heterogeneity and autonomy. A systematic theory and methodology for control of large-scale interconnected systems is therefore needed. In an ambitious effort towards this goal, this project will develop rigorous tools for control synthesis, adaptation and verification.
Many large-scale systems exhibit properties that have not yet been systematically exploited by the control community. One such property is positive (or monotone) system dynamics. This correspond to the property that all states of a network respond in the same direction when the demand or supply is perturbed in some node. Scalable methods for control of positive systems are starting to be developed, but several fundamental questions remain: How can existing results be extended to scalable synthesis of dynamic controllers? Can results for linear positive systems be extended to nonlinear monotone ones? How about systems with resonances?
The second focus area, adaptation, takes advantage of recent progress in machine learning, such as statistical concentration bounds and approximate dynamic programming. Adaptation is of fundamental importance for scalability, since high-fidelity models are very expensive to generate manually and hard to maintain. Thirdly, since systematic procedures for control synthesis generally rely on simplified models and idealized assumptions, we will also develop scalable methods to bound the effect of imperfections, such as nonlinearities, time-variations and parameter uncertainty that are not taken into account in the original design.
The research will be carried out in interaction with industry studying a new concept for district heating networks. This collaboration will give access to experimental data from a full scale demonstration plant.
Summary
Modern society is critically dependent on large-scale networks for services such as energy supply, transportation and communications. The design and control of such networks is becoming increasingly complex, due to their growing size, heterogeneity and autonomy. A systematic theory and methodology for control of large-scale interconnected systems is therefore needed. In an ambitious effort towards this goal, this project will develop rigorous tools for control synthesis, adaptation and verification.
Many large-scale systems exhibit properties that have not yet been systematically exploited by the control community. One such property is positive (or monotone) system dynamics. This correspond to the property that all states of a network respond in the same direction when the demand or supply is perturbed in some node. Scalable methods for control of positive systems are starting to be developed, but several fundamental questions remain: How can existing results be extended to scalable synthesis of dynamic controllers? Can results for linear positive systems be extended to nonlinear monotone ones? How about systems with resonances?
The second focus area, adaptation, takes advantage of recent progress in machine learning, such as statistical concentration bounds and approximate dynamic programming. Adaptation is of fundamental importance for scalability, since high-fidelity models are very expensive to generate manually and hard to maintain. Thirdly, since systematic procedures for control synthesis generally rely on simplified models and idealized assumptions, we will also develop scalable methods to bound the effect of imperfections, such as nonlinearities, time-variations and parameter uncertainty that are not taken into account in the original design.
The research will be carried out in interaction with industry studying a new concept for district heating networks. This collaboration will give access to experimental data from a full scale demonstration plant.
Max ERC Funding
2 500 000 €
Duration
Start date: 2019-09-01, End date: 2024-08-31
Project acronym SELF-UNITY
Project The Unity of the Bodily Self
Researcher (PI) Hans Henrik EHRSSON
Host Institution (HI) KAROLINSKA INSTITUTET
Country Sweden
Call Details Advanced Grant (AdG), SH4, ERC-2017-ADG
Summary How do we come to experience ourselves as single physical entities? Under normal healthy conditions, we humans always experience a single body as our own physical self, and this bodily self is undivided and perceived as a single whole. But what cognitive processes and brain mechanisms mediate this unity of the bodily self? This fundamental question has long been beyond the reach of experimental studies because of the lack of behavioral paradigms that allow controlled manipulation of basic components of the self-unity. To address this issue, we here propose the use of novel full-body illusion paradigms to “fragment”, “duplicate” or “split” the sense of bodily self during well-controlled behavioral and neuroimaging experiments. By studying the behavioral and neural principles that determine specific illusory changes in perceived self-unity, we can elucidate much about the neurocognitive mechanisms that support the sense of having a single unitary bodily self under normal conditions. Our pioneering behavioral paradigms utilize the newest virtual reality technologies, and these are combined with multimodal neuroimaging using the most advanced analysis methods, such as multivariate pattern recognition. The aims of the project are to unravel (i) how we come to experience a single bodily self as opposed to multiple ones; (ii) how we perceive a coherent bodily self instead of fragmented parts; and (iii) how information from different sensory modalities – including vestibular and interoceptive signals – are integrated to achieve this coherent sense of a singular bodily self. The new basic knowledge generated by this project will be important for future clinical neuroscience research into major psychiatric and neurological disorders with disturbances in self-unity, such as schizophrenia, dissociative disorders and stroke with body neglect, by providing novel ideas for hypotheses about the involved neurocognitive pathophysiology.
Summary
How do we come to experience ourselves as single physical entities? Under normal healthy conditions, we humans always experience a single body as our own physical self, and this bodily self is undivided and perceived as a single whole. But what cognitive processes and brain mechanisms mediate this unity of the bodily self? This fundamental question has long been beyond the reach of experimental studies because of the lack of behavioral paradigms that allow controlled manipulation of basic components of the self-unity. To address this issue, we here propose the use of novel full-body illusion paradigms to “fragment”, “duplicate” or “split” the sense of bodily self during well-controlled behavioral and neuroimaging experiments. By studying the behavioral and neural principles that determine specific illusory changes in perceived self-unity, we can elucidate much about the neurocognitive mechanisms that support the sense of having a single unitary bodily self under normal conditions. Our pioneering behavioral paradigms utilize the newest virtual reality technologies, and these are combined with multimodal neuroimaging using the most advanced analysis methods, such as multivariate pattern recognition. The aims of the project are to unravel (i) how we come to experience a single bodily self as opposed to multiple ones; (ii) how we perceive a coherent bodily self instead of fragmented parts; and (iii) how information from different sensory modalities – including vestibular and interoceptive signals – are integrated to achieve this coherent sense of a singular bodily self. The new basic knowledge generated by this project will be important for future clinical neuroscience research into major psychiatric and neurological disorders with disturbances in self-unity, such as schizophrenia, dissociative disorders and stroke with body neglect, by providing novel ideas for hypotheses about the involved neurocognitive pathophysiology.
Max ERC Funding
2 583 560 €
Duration
Start date: 2019-01-01, End date: 2023-12-31
Project acronym SYSTEAM
Project Systems and Signals Tools for Estimation and Analysis of Mathematical Models in Endocrinology and Neurology
Researcher (PI) Peter Stoica
Host Institution (HI) UPPSALA UNIVERSITET
Country Sweden
Call Details Advanced Grant (AdG), PE7, ERC-2009-AdG
Summary This proposal envisages a research program in the field of systems and signals that will lead to innovative and agile mathematical modeling as well as model-based signal processing and control tools for applications in biology and medicine. The project's goal is to bridge the gap between systems biology, on one hand, and medical signal processing and control engineering, on the other. Mathematical models of systems biology will be used to devise algorithms for biological data processing and computerized medical interventions. Experimental biological and clinical data will be utilized to estimate and characterize the parameters of mathematical models derived for biological phenomena and mechanisms. An extensive collaboration network of medical researchers from Sweden and abroad will provide the project team with necessary experimental data as well as with access to medical competence. The envisaged tools are expected to be applicable more generally but their efficacy will be demonstrated in two main application areas. These areas are endocrinology and neurology for which the use of formal control engineering and signal processing methods is currently deemed to be most promising. The proposed program will result in novel systems and signals tools for medical research and health care enabling multi-input multi-output modeling and analysis of endocrine regulations and providing model-based algorithms for individualized drug dose titration.
Summary
This proposal envisages a research program in the field of systems and signals that will lead to innovative and agile mathematical modeling as well as model-based signal processing and control tools for applications in biology and medicine. The project's goal is to bridge the gap between systems biology, on one hand, and medical signal processing and control engineering, on the other. Mathematical models of systems biology will be used to devise algorithms for biological data processing and computerized medical interventions. Experimental biological and clinical data will be utilized to estimate and characterize the parameters of mathematical models derived for biological phenomena and mechanisms. An extensive collaboration network of medical researchers from Sweden and abroad will provide the project team with necessary experimental data as well as with access to medical competence. The envisaged tools are expected to be applicable more generally but their efficacy will be demonstrated in two main application areas. These areas are endocrinology and neurology for which the use of formal control engineering and signal processing methods is currently deemed to be most promising. The proposed program will result in novel systems and signals tools for medical research and health care enabling multi-input multi-output modeling and analysis of endocrine regulations and providing model-based algorithms for individualized drug dose titration.
Max ERC Funding
2 379 000 €
Duration
Start date: 2010-04-01, End date: 2015-03-31
Project acronym THE RISE
Project Travels, transmissions and transformations in the 3rd and 2nd millennium BC in northern Europe: the rise of
Bronze Age societies
Researcher (PI) Kristian Kristiansen
Host Institution (HI) GOETEBORGS UNIVERSITET
Country Sweden
Call Details Advanced Grant (AdG), SH6, ERC-2010-AdG_20100407
Summary Research problem: The 3rd and 2nd millennium was a period that saw major social and cultural transformations in Europe, from migrations and the introduction of metal (the Bronze Age) to new cultural identities and languages. As these two millennia were formative for Europe’s later history, these are hotly debated issues. However, they can now be resolved, at least in part, by the application of new science-based methodologies and the development of new interpretative frameworks.
Aims and methodologies: The project does so by adopting an interdisciplinary methodological approach that combines science and culture. Isotope tracing in combination with recent advances in ancient DNA is employed to test human origins and movements during the two millennia, as well as the origin of wool and textiles. Lead isotope is adopted to trace the origin of copper. Based on this the project will document and explain the forging of new identities and new types of interaction during the 3rd and 2nd millennium BC in temperate northern Europe, but with implications for western Eurasia.
Progress and originality: Accomplishment of front-line research results by combining archaeology with new developments in the natural sciences to produce new knowledge about the mobility of people, animals, things, ideas and technologies. This will allow a critical comparison of different types of evidence on mobility from DNA to strontium isotope analyses, and will lead to improved knowledge about the ways in which European regional cultures and identities were formed in the Bronze Age through interaction. Finally, the project will potentially change our understanding and thinking about human mobility as a key factor in cultural and social change.
Summary
Research problem: The 3rd and 2nd millennium was a period that saw major social and cultural transformations in Europe, from migrations and the introduction of metal (the Bronze Age) to new cultural identities and languages. As these two millennia were formative for Europe’s later history, these are hotly debated issues. However, they can now be resolved, at least in part, by the application of new science-based methodologies and the development of new interpretative frameworks.
Aims and methodologies: The project does so by adopting an interdisciplinary methodological approach that combines science and culture. Isotope tracing in combination with recent advances in ancient DNA is employed to test human origins and movements during the two millennia, as well as the origin of wool and textiles. Lead isotope is adopted to trace the origin of copper. Based on this the project will document and explain the forging of new identities and new types of interaction during the 3rd and 2nd millennium BC in temperate northern Europe, but with implications for western Eurasia.
Progress and originality: Accomplishment of front-line research results by combining archaeology with new developments in the natural sciences to produce new knowledge about the mobility of people, animals, things, ideas and technologies. This will allow a critical comparison of different types of evidence on mobility from DNA to strontium isotope analyses, and will lead to improved knowledge about the ways in which European regional cultures and identities were formed in the Bronze Age through interaction. Finally, the project will potentially change our understanding and thinking about human mobility as a key factor in cultural and social change.
Max ERC Funding
2 488 264 €
Duration
Start date: 2011-06-01, End date: 2016-05-31