Project acronym BigFastData
Project Charting a New Horizon of Big and Fast Data Analysis through Integrated Algorithm Design
Researcher (PI) Yanlei DIAO
Host Institution (HI) ECOLE POLYTECHNIQUE
Call Details Consolidator Grant (CoG), PE6, ERC-2016-COG
Summary This proposal addresses a pressing need from emerging big data applications such as genomics and data center monitoring: besides the scale of processing, big data systems must also enable perpetual, low-latency processing for a broad set of analytical tasks, referred to as big and fast data analysis. Today’s technology falls severely short for such needs due to the lack of support of complex analytics with scale, low latency, and strong guarantees of user performance requirements. To bridge the gap, this proposal tackles a grand challenge: “How do we design an algorithmic foundation that enables the development of all necessary pillars of big and fast data analysis?” This proposal considers three pillars:
1) Parallelism: There is a fundamental tension between data parallelism (for scale) and pipeline parallelism (for low latency). We propose new approaches based on intelligent use of memory and workload properties to integrate both forms of parallelism.
2) Analytics: The literature lacks a large body of algorithms for critical order-related analytics to be run under data and pipeline parallelism. We propose new algorithmic frameworks to enable such analytics.
3) Optimization: To run analytics, today's big data systems are best effort only. We transform such systems into a principled optimization framework that suits the new characteristics of big data infrastructure and adapts to meet user performance requirements.
The scale and complexity of the proposed algorithm design makes this project high-risk, at the same time, high-gain: it will lay a solid foundation for big and fast data analysis, enabling a new integrated parallel processing paradigm, algorithms for critical order-related analytics, and a principled optimizer with strong performance guarantees. It will also broadly enable accelerated information discovery in emerging domains such as genomics, as well as economic benefits of early, well-informed decisions and reduced user payments.
Summary
This proposal addresses a pressing need from emerging big data applications such as genomics and data center monitoring: besides the scale of processing, big data systems must also enable perpetual, low-latency processing for a broad set of analytical tasks, referred to as big and fast data analysis. Today’s technology falls severely short for such needs due to the lack of support of complex analytics with scale, low latency, and strong guarantees of user performance requirements. To bridge the gap, this proposal tackles a grand challenge: “How do we design an algorithmic foundation that enables the development of all necessary pillars of big and fast data analysis?” This proposal considers three pillars:
1) Parallelism: There is a fundamental tension between data parallelism (for scale) and pipeline parallelism (for low latency). We propose new approaches based on intelligent use of memory and workload properties to integrate both forms of parallelism.
2) Analytics: The literature lacks a large body of algorithms for critical order-related analytics to be run under data and pipeline parallelism. We propose new algorithmic frameworks to enable such analytics.
3) Optimization: To run analytics, today's big data systems are best effort only. We transform such systems into a principled optimization framework that suits the new characteristics of big data infrastructure and adapts to meet user performance requirements.
The scale and complexity of the proposed algorithm design makes this project high-risk, at the same time, high-gain: it will lay a solid foundation for big and fast data analysis, enabling a new integrated parallel processing paradigm, algorithms for critical order-related analytics, and a principled optimizer with strong performance guarantees. It will also broadly enable accelerated information discovery in emerging domains such as genomics, as well as economic benefits of early, well-informed decisions and reduced user payments.
Max ERC Funding
2 472 752 €
Duration
Start date: 2017-09-01, End date: 2022-08-31
Project acronym BrainDyn
Project Tracking information flow in the brain: A unified and general framework for dynamic communication in brain networks
Researcher (PI) Mathilde BONNEFOND
Host Institution (HI) INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Call Details Starting Grant (StG), LS5, ERC-2016-STG
Summary The brain is composed of a set of areas specialized in specific computations whose outputs need to be transferred to other specialized areas for cognition to emerge. To account for context-dependent behaviors, the information has to be flexibly routed through the fixed anatomy of the brain. The aim of my proposal is to test a general framework for flexible communication between brain areas based on nested oscillations which I recently developed. The general idea is that internally-driven slow oscillations (<20Hz) either set-up or prevent the communication between brain areas. Stimulus-driven gamma oscillations (>30Hz), nested in the slow oscillations, can then be directed to task-relevant areas of the network. I plan to use a multimodal, multi-scale and transversal (human and monkey) approach in experiments manipulating visual processing, attention and memory to test core predictions of my framework. The theoretical approach and the methodological development used in my project will provide the basis for future fundamental and clinical research.
Summary
The brain is composed of a set of areas specialized in specific computations whose outputs need to be transferred to other specialized areas for cognition to emerge. To account for context-dependent behaviors, the information has to be flexibly routed through the fixed anatomy of the brain. The aim of my proposal is to test a general framework for flexible communication between brain areas based on nested oscillations which I recently developed. The general idea is that internally-driven slow oscillations (<20Hz) either set-up or prevent the communication between brain areas. Stimulus-driven gamma oscillations (>30Hz), nested in the slow oscillations, can then be directed to task-relevant areas of the network. I plan to use a multimodal, multi-scale and transversal (human and monkey) approach in experiments manipulating visual processing, attention and memory to test core predictions of my framework. The theoretical approach and the methodological development used in my project will provide the basis for future fundamental and clinical research.
Max ERC Funding
1 333 718 €
Duration
Start date: 2017-02-01, End date: 2022-01-31
Project acronym D3
Project Interpreting Drawings for 3D Design
Researcher (PI) Adrien BOUSSEAU
Host Institution (HI) INSTITUT NATIONAL DE RECHERCHE ENINFORMATIQUE ET AUTOMATIQUE
Call Details Starting Grant (StG), PE6, ERC-2016-STG
Summary Designers draw extensively to externalize their ideas and communicate with others. However, drawings are currently not directly interpretable by computers. To test their ideas against physical reality, designers have to create 3D models suitable for simulation and 3D printing. However, the visceral and approximate nature of drawing clashes with the tediousness and rigidity of 3D modeling. As a result, designers only model finalized concepts, and have no feedback on feasibility during creative exploration.
Our ambition is to bring the power of 3D engineering tools to the creative phase of design by automatically estimating 3D models from drawings. However, this problem is ill-posed: a point in the drawing can lie anywhere in depth. Existing solutions are limited to simple shapes, or require user input to “explain” to the computer how to interpret the drawing. Our originality is to exploit professional drawing techniques that designers developed to communicate shape most efficiently. Each technique provides geometric constraints that help viewers understand drawings, and that we shall leverage for 3D reconstruction.
Our first challenge is to formalize common drawing techniques and derive how they constrain 3D shape. Our second challenge is to identify which techniques are used in a drawing. We cast this problem as the joint optimization of discrete variables indicating which constraints apply, and continuous variables representing the 3D model that best satisfies these constraints. But evaluating all constraint configurations is impractical. To solve this inverse problem, we will first develop forward algorithms that synthesize drawings from 3D models. Our idea is to use this synthetic data to train machine learning algorithms that predict the likelihood that constraints apply in a given drawing.
In addition to tackling the long-standing problem of single-image 3D reconstruction, our research will significantly tighten design and engineering for rapid prototyping.
Summary
Designers draw extensively to externalize their ideas and communicate with others. However, drawings are currently not directly interpretable by computers. To test their ideas against physical reality, designers have to create 3D models suitable for simulation and 3D printing. However, the visceral and approximate nature of drawing clashes with the tediousness and rigidity of 3D modeling. As a result, designers only model finalized concepts, and have no feedback on feasibility during creative exploration.
Our ambition is to bring the power of 3D engineering tools to the creative phase of design by automatically estimating 3D models from drawings. However, this problem is ill-posed: a point in the drawing can lie anywhere in depth. Existing solutions are limited to simple shapes, or require user input to “explain” to the computer how to interpret the drawing. Our originality is to exploit professional drawing techniques that designers developed to communicate shape most efficiently. Each technique provides geometric constraints that help viewers understand drawings, and that we shall leverage for 3D reconstruction.
Our first challenge is to formalize common drawing techniques and derive how they constrain 3D shape. Our second challenge is to identify which techniques are used in a drawing. We cast this problem as the joint optimization of discrete variables indicating which constraints apply, and continuous variables representing the 3D model that best satisfies these constraints. But evaluating all constraint configurations is impractical. To solve this inverse problem, we will first develop forward algorithms that synthesize drawings from 3D models. Our idea is to use this synthetic data to train machine learning algorithms that predict the likelihood that constraints apply in a given drawing.
In addition to tackling the long-standing problem of single-image 3D reconstruction, our research will significantly tighten design and engineering for rapid prototyping.
Max ERC Funding
1 482 761 €
Duration
Start date: 2017-02-01, End date: 2022-01-31
Project acronym DYNMECH
Project Dynamic Mechanisms
Researcher (PI) Daniel Ferguson Garrett
Host Institution (HI) FONDATION JEAN-JACQUES LAFFONT,TOULOUSE SCIENCES ECONOMIQUES
Call Details Starting Grant (StG), SH1, ERC-2016-STG
Summary This project studies dynamic mechanisms. By “dynamic mechanisms”, we mean policies to which a principal (e.g., a seller, an employer, or a regulator) can commit to induce the agents (e.g., buyers, employees, or regulated firms) to take the desired actions over time. Several components of the project are envisaged:
- Competition in dynamic mechanisms.
o I propose a competitive setting in which agents (e.g., buyers or workers) learn about the offers of different principals over time. Agents may receive more than one offer at a time, leading to direct competition between mechanisms. Received offers are agents’ private information, permitting strategic delay of acceptance (for instance, an agent may want to wait to evaluate new offers that received in the future).
- Robust predictions for a rich class of stochastic processes.
o We study optimal dynamic mechanisms for agents whose preferences evolve stochastically with time. We develop an approach to partially characterizing these mechanisms which (unlike virtually all of the existing literature) does not depend on ad-hoc restrictions on the stochastic process for preferences.
- Efficient bilateral trade with budget balance: dynamic arrival of traders
o I study bilateral trade with budget balance, when traders (i) arrive over time, and (ii) have preferences which evolve stochastically with time. The project aims at an impossibility result in this setting: contrary to the existing literature which does not account for dynamic arrivals, budget-balanced efficient trade is typically impossible, even for very patient traders.
- Pre-event ticket sales and complementary investments
o We provide a rationale for the early allocation of capacity to customers for events such as flights and concerts based on customers’ demand for pre-event complementary investments (such as booking a hotel or a babysitter). We examine efficient and profit-maximizing mechanisms.
Summary
This project studies dynamic mechanisms. By “dynamic mechanisms”, we mean policies to which a principal (e.g., a seller, an employer, or a regulator) can commit to induce the agents (e.g., buyers, employees, or regulated firms) to take the desired actions over time. Several components of the project are envisaged:
- Competition in dynamic mechanisms.
o I propose a competitive setting in which agents (e.g., buyers or workers) learn about the offers of different principals over time. Agents may receive more than one offer at a time, leading to direct competition between mechanisms. Received offers are agents’ private information, permitting strategic delay of acceptance (for instance, an agent may want to wait to evaluate new offers that received in the future).
- Robust predictions for a rich class of stochastic processes.
o We study optimal dynamic mechanisms for agents whose preferences evolve stochastically with time. We develop an approach to partially characterizing these mechanisms which (unlike virtually all of the existing literature) does not depend on ad-hoc restrictions on the stochastic process for preferences.
- Efficient bilateral trade with budget balance: dynamic arrival of traders
o I study bilateral trade with budget balance, when traders (i) arrive over time, and (ii) have preferences which evolve stochastically with time. The project aims at an impossibility result in this setting: contrary to the existing literature which does not account for dynamic arrivals, budget-balanced efficient trade is typically impossible, even for very patient traders.
- Pre-event ticket sales and complementary investments
o We provide a rationale for the early allocation of capacity to customers for events such as flights and concerts based on customers’ demand for pre-event complementary investments (such as booking a hotel or a babysitter). We examine efficient and profit-maximizing mechanisms.
Max ERC Funding
1 321 625 €
Duration
Start date: 2017-01-01, End date: 2021-12-31
Project acronym EmpoweredLifeYears
Project The Demography of Sustainable Human Wellbeing
Researcher (PI) Wolfgang Lutz
Host Institution (HI) INTERNATIONALES INSTITUT FUER ANGEWANDTE SYSTEMANALYSE
Call Details Advanced Grant (AdG), SH3, ERC-2016-ADG
Summary This project will apply two distinctly demographic concepts to research questions that go far beyond demography. The wellbeing indicators proposed here will be based on life table methods and the recently operationalized concept of Demographic Metabolism – modelling social change through the replacement of generations – will be used to get a quantitative analytical handle on the temporal dynamics of improving human wellbeing.
The project will theoretically develop, empirically estimate, test and forecast indicators of human wellbeing that are based on life table methods and hence reflect the basic – but often overlooked fact – that being alive is a necessary prerequisite for enjoying any quality of life. But since mere survival is not sufficient as an ultimate goal for most people the person years lived at each age will be weighted with four different dimensions of empowerment: health, literacy, happiness and being out of poverty. These are four dimensions of an indicator tentatively called ELY (Empowered Life Years). ELY will also serve as the explanandum of a global level econometric estimation of the determinants of wellbeing considering human, manufactured and natural capitals as well as knowledge and institutions.
The global level analysis is complemented by a set of strategically chosen in-depth systems-analytical case studies in Namibia/Western Cape, Nepal, Costa Rica and historical Finland modelling the population-development-environment (PDE) interactions including feed-backs e.g. from environmental degradation to wellbeing and taking the trends of ELY in different sub-populations as sustainability criteria. They will also include stake holder involvement and science-policy interactions.
This innovative inter-disciplinary cross-fertilisation can potentially make an important contribution to the current discussions about operationalizing the criteria and end goal of sustainable development and developing better human wellbeing based metrics of progress.
Summary
This project will apply two distinctly demographic concepts to research questions that go far beyond demography. The wellbeing indicators proposed here will be based on life table methods and the recently operationalized concept of Demographic Metabolism – modelling social change through the replacement of generations – will be used to get a quantitative analytical handle on the temporal dynamics of improving human wellbeing.
The project will theoretically develop, empirically estimate, test and forecast indicators of human wellbeing that are based on life table methods and hence reflect the basic – but often overlooked fact – that being alive is a necessary prerequisite for enjoying any quality of life. But since mere survival is not sufficient as an ultimate goal for most people the person years lived at each age will be weighted with four different dimensions of empowerment: health, literacy, happiness and being out of poverty. These are four dimensions of an indicator tentatively called ELY (Empowered Life Years). ELY will also serve as the explanandum of a global level econometric estimation of the determinants of wellbeing considering human, manufactured and natural capitals as well as knowledge and institutions.
The global level analysis is complemented by a set of strategically chosen in-depth systems-analytical case studies in Namibia/Western Cape, Nepal, Costa Rica and historical Finland modelling the population-development-environment (PDE) interactions including feed-backs e.g. from environmental degradation to wellbeing and taking the trends of ELY in different sub-populations as sustainability criteria. They will also include stake holder involvement and science-policy interactions.
This innovative inter-disciplinary cross-fertilisation can potentially make an important contribution to the current discussions about operationalizing the criteria and end goal of sustainable development and developing better human wellbeing based metrics of progress.
Max ERC Funding
1 819 250 €
Duration
Start date: 2017-11-01, End date: 2022-10-31
Project acronym EnergyMemo
Project Dynamic Interplay between Energy and Memory
Researcher (PI) Thomas Jules Henri PREAT
Host Institution (HI) CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Call Details Advanced Grant (AdG), LS5, ERC-2016-ADG
Summary Understanding the links between neuronal plasticity which underlies memory and energy metabolism is a major goal of brain studies. The brain is a main energy consumer and the central regulator of energy homeostasis, and it prioritizes its own supply over peripheral organs. Interestingly, our work demonstrates that the brain is also able to regulate its own activity under energy shortage to favor survival.
The EnergyMemo project proposes to perform in drosophila an original integrated study of the interplay between energy metabolism and olfactory memory at the molecular, cellular and circuit levels. On the ground of important preliminary results, we will investigate in vivo how and why the energy flux increases during long-term memory encoding, and how brain plasticity is regulated by the energy supply. We will focus on three major challenges:
* Objective 1: to improve our understanding of brain physiology, we will characterize in drosophila neuronal circuits that integrate information about the brain energy status.
* Objective 2: to understand how abnormal levels of energy can affect the brain, we will analyze how the energy level shapes the functioning of the olfactory memory center.
* Objective 3: to characterize how energy stores are mobilized during memory formation, we will investigate how the neuronal and glial networks interact to manage the energy fluxes.
This multidisciplinary project will benefit from our team's longstanding experience in behavioral studies and leadership in live brain imaging, in addition to the unmatched descriptive power of drosophila neuronal circuits at the single-neuron resolution. Successful completion of this program will surely uncover mechanisms of brain function conserved across species, and should bring-up new ideas about how deregulation of energy metabolism can affect cognitive functions in human. Thus the EnergyMemo project could have a major impact in neuroscience from fundamental research to human applications.
Summary
Understanding the links between neuronal plasticity which underlies memory and energy metabolism is a major goal of brain studies. The brain is a main energy consumer and the central regulator of energy homeostasis, and it prioritizes its own supply over peripheral organs. Interestingly, our work demonstrates that the brain is also able to regulate its own activity under energy shortage to favor survival.
The EnergyMemo project proposes to perform in drosophila an original integrated study of the interplay between energy metabolism and olfactory memory at the molecular, cellular and circuit levels. On the ground of important preliminary results, we will investigate in vivo how and why the energy flux increases during long-term memory encoding, and how brain plasticity is regulated by the energy supply. We will focus on three major challenges:
* Objective 1: to improve our understanding of brain physiology, we will characterize in drosophila neuronal circuits that integrate information about the brain energy status.
* Objective 2: to understand how abnormal levels of energy can affect the brain, we will analyze how the energy level shapes the functioning of the olfactory memory center.
* Objective 3: to characterize how energy stores are mobilized during memory formation, we will investigate how the neuronal and glial networks interact to manage the energy fluxes.
This multidisciplinary project will benefit from our team's longstanding experience in behavioral studies and leadership in live brain imaging, in addition to the unmatched descriptive power of drosophila neuronal circuits at the single-neuron resolution. Successful completion of this program will surely uncover mechanisms of brain function conserved across species, and should bring-up new ideas about how deregulation of energy metabolism can affect cognitive functions in human. Thus the EnergyMemo project could have a major impact in neuroscience from fundamental research to human applications.
Max ERC Funding
2 499 500 €
Duration
Start date: 2017-10-01, End date: 2022-09-30
Project acronym FIRMNET
Project Firms and Their Networks
Researcher (PI) Francis KRAMARZ
Host Institution (HI) CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Call Details Advanced Grant (AdG), SH1, ERC-2016-ADG
Summary There is mounting evidence that firms are becoming more fragmented; production is less often made “in-house”. Firms buy inputs from abroad. Tasks are often split in parts. Some are offshored, others are subcontracted. Hence, firms buy services from other, local or international, firms. But they also supply inputs to other firms. Technical change, the internet, and globalization, all facilitate this transformation.
In order to better understand how firms thrive in the new global environment, the proposed research aims to construct a networks view of the firm. Fragmentation offers new opportunities: firms may specialize in what they make best, hence creating a business network of customers and suppliers. Networks are also useful to secure provision of fragmented tasks. The firms’ suppliers of goods and services – accountants, logisticians, consultants… -- may well be related to the firm through its workers’ social networks: family ties, boardroom relations… These social networks should be useful when times are tough -- board members could help find financing in banks where their schoolmates have a job – or when times are unusually good -- employees could help in spotting the right hires among their former co-workers.
The proposed research will focus on how firms social and business networks help firms to be resilient in the face of shocks. Resilience will be measured using the firms’ and workers’ outcomes – value-added, wages, employment, or occupations. The research will have a theoretical component using general equilibrium models with heterogeneous firms, an empirical component with unique data sources from at least two countries (France, Sweden), and an “econometric theory” component which will seek to develop techniques for the study of many-to-one matches in the presence of networks. The research will speak to the labor economics community but also to the international trade community, the management community, as well as the econometrics community.
Summary
There is mounting evidence that firms are becoming more fragmented; production is less often made “in-house”. Firms buy inputs from abroad. Tasks are often split in parts. Some are offshored, others are subcontracted. Hence, firms buy services from other, local or international, firms. But they also supply inputs to other firms. Technical change, the internet, and globalization, all facilitate this transformation.
In order to better understand how firms thrive in the new global environment, the proposed research aims to construct a networks view of the firm. Fragmentation offers new opportunities: firms may specialize in what they make best, hence creating a business network of customers and suppliers. Networks are also useful to secure provision of fragmented tasks. The firms’ suppliers of goods and services – accountants, logisticians, consultants… -- may well be related to the firm through its workers’ social networks: family ties, boardroom relations… These social networks should be useful when times are tough -- board members could help find financing in banks where their schoolmates have a job – or when times are unusually good -- employees could help in spotting the right hires among their former co-workers.
The proposed research will focus on how firms social and business networks help firms to be resilient in the face of shocks. Resilience will be measured using the firms’ and workers’ outcomes – value-added, wages, employment, or occupations. The research will have a theoretical component using general equilibrium models with heterogeneous firms, an empirical component with unique data sources from at least two countries (France, Sweden), and an “econometric theory” component which will seek to develop techniques for the study of many-to-one matches in the presence of networks. The research will speak to the labor economics community but also to the international trade community, the management community, as well as the econometrics community.
Max ERC Funding
1 753 288 €
Duration
Start date: 2017-09-01, End date: 2022-08-31
Project acronym FRAGCLIM
Project The Combined Effects of Climatic Warming and Habitat Fragmentation on Biodiversity, Community Dynamics and Ecosystem Functioning
Researcher (PI) Jose Maria MONTOYA TERAN
Host Institution (HI) CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Call Details Consolidator Grant (CoG), LS8, ERC-2016-COG
Summary Climatic warming and habitat fragmentation are the largest threats to biodiversity and ecosystems globally. To forecast and mitigate their effects is the environmental challenge of our age. Despite substantial progress on the ecological consequences of climatic warming and habitat fragmentation individually, there is a fundamental gap in our understanding and prediction of their combined effects.
The goal of FRAGCLIM is to determine the individual and combined effects of climatic warming and habitat fragmentation on biodiversity, community dynamics, and ecosystem functioning in complex multitrophic communities. To achieve this, it uses an integrative approach that combines the development of new theory on metacommunities and temperature-dependent food web dynamics in close dialogue with a unique long-term aquatic mesocosm experiment. It is articulated around five objectives. In the first three, FRAGCLIM will determine the effects of (i) warming, (ii) fragmentation, and (iii) warming and fragmentation combined, on numerous facets of biodiversity, community structure, food web dynamics, spatial and temporal stability, and key ecosystem functions. Then, it will (iv) investigate the extent of evolutionary thermal adaptation to warming and isolation due to fragmentation, and its consequences for biodiversity dynamics. Finally, (v) it will provide creative solutions to mitigate the combined effects of warming and fragmentation.
FRAGCLIM proposes an ambitious integrative and innovative research programme that will provide a much-needed new perspective on the ecological and evolutionary consequences of warming and fragmentation. It will greatly contribute to bridging the gaps between theoretical and empirical ecology, and between ecological and evolutionary responses to global change. FRAGCLIM will foster links with environmental policy by providing new mitigation measures to climate change in fragmented systems that derive from our theoretical and empirical findings.
Summary
Climatic warming and habitat fragmentation are the largest threats to biodiversity and ecosystems globally. To forecast and mitigate their effects is the environmental challenge of our age. Despite substantial progress on the ecological consequences of climatic warming and habitat fragmentation individually, there is a fundamental gap in our understanding and prediction of their combined effects.
The goal of FRAGCLIM is to determine the individual and combined effects of climatic warming and habitat fragmentation on biodiversity, community dynamics, and ecosystem functioning in complex multitrophic communities. To achieve this, it uses an integrative approach that combines the development of new theory on metacommunities and temperature-dependent food web dynamics in close dialogue with a unique long-term aquatic mesocosm experiment. It is articulated around five objectives. In the first three, FRAGCLIM will determine the effects of (i) warming, (ii) fragmentation, and (iii) warming and fragmentation combined, on numerous facets of biodiversity, community structure, food web dynamics, spatial and temporal stability, and key ecosystem functions. Then, it will (iv) investigate the extent of evolutionary thermal adaptation to warming and isolation due to fragmentation, and its consequences for biodiversity dynamics. Finally, (v) it will provide creative solutions to mitigate the combined effects of warming and fragmentation.
FRAGCLIM proposes an ambitious integrative and innovative research programme that will provide a much-needed new perspective on the ecological and evolutionary consequences of warming and fragmentation. It will greatly contribute to bridging the gaps between theoretical and empirical ecology, and between ecological and evolutionary responses to global change. FRAGCLIM will foster links with environmental policy by providing new mitigation measures to climate change in fragmented systems that derive from our theoretical and empirical findings.
Max ERC Funding
1 998 802 €
Duration
Start date: 2017-06-01, End date: 2022-05-31
Project acronym FunKeyGut
Project Illuminating Functional Networks and Keystone Species in the Gut
Researcher (PI) David Michael BERRY
Host Institution (HI) UNIVERSITAT WIEN
Call Details Starting Grant (StG), LS8, ERC-2016-STG
Summary We live in an intimate symbiosis with our gut microbiota, which provides us services such as vitamin production, breakdown of dietary compounds, and immune training. Sequencing-based approaches that have been applied to catalogue the gut microbiota have revealed intriguing discoveries associating the microbiome with diet and disease. The next outstanding challenge is to unravel the many activities and interactions that define gut microbiota function.
The gut microbiota is a diverse community of cooperating and competing microbes. These interactions form a network that links organisms with each other and their environment. Interactions in such a “functional network” are based partially, though not exclusively, on food webs. Certain “keystone species”, such as Rumonicoccus bromii, are thought to play a major role in these networks. Though some evidence exists for the presence of keystone species, their identity and activity remains largely unknown. As keystone species are vital to networks they are ideal targets for manipulating the gut microbiota to improve metabolic health and protect against enteropathogen infection.
Given the complexity of the gut microbiota, networks can only be elucidated directly in the native community. This project aims to identify functional networks and keystone species in the human gut using novel approaches that are uniquely and ideally suited for studying microbial activity in complex communities. Using state-of-the-art methods such as stable isotope labeling, Raman microspectroscopy, and secondary ion mass spectrometry (NanoSIMS) we will illuminate functional networks in situ. This will allow us to identify what factors shape gut microbiota activity, reveal important food webs, and ultimately use network knowledge to target the microbiota with prebiotic/probiotic treatments rationally designed to promote health.
Summary
We live in an intimate symbiosis with our gut microbiota, which provides us services such as vitamin production, breakdown of dietary compounds, and immune training. Sequencing-based approaches that have been applied to catalogue the gut microbiota have revealed intriguing discoveries associating the microbiome with diet and disease. The next outstanding challenge is to unravel the many activities and interactions that define gut microbiota function.
The gut microbiota is a diverse community of cooperating and competing microbes. These interactions form a network that links organisms with each other and their environment. Interactions in such a “functional network” are based partially, though not exclusively, on food webs. Certain “keystone species”, such as Rumonicoccus bromii, are thought to play a major role in these networks. Though some evidence exists for the presence of keystone species, their identity and activity remains largely unknown. As keystone species are vital to networks they are ideal targets for manipulating the gut microbiota to improve metabolic health and protect against enteropathogen infection.
Given the complexity of the gut microbiota, networks can only be elucidated directly in the native community. This project aims to identify functional networks and keystone species in the human gut using novel approaches that are uniquely and ideally suited for studying microbial activity in complex communities. Using state-of-the-art methods such as stable isotope labeling, Raman microspectroscopy, and secondary ion mass spectrometry (NanoSIMS) we will illuminate functional networks in situ. This will allow us to identify what factors shape gut microbiota activity, reveal important food webs, and ultimately use network knowledge to target the microbiota with prebiotic/probiotic treatments rationally designed to promote health.
Max ERC Funding
1 498 279 €
Duration
Start date: 2017-04-01, End date: 2022-03-31
Project acronym GRAVIBONE
Project How Bone Adapts to Heavy Weight?Bone Morphological and Microanatomical Adaptation to the Mechanical Constraints Imposed by Graviportality
Researcher (PI) Alexandra Christine HOUSSAYE
Host Institution (HI) CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Call Details Starting Grant (StG), LS8, ERC-2016-STG
Summary Heavy animals, said to be graviportal, are under strong mechanical constraints. Their skeleton, notably their limb bones, show convergent morpho-functional adaptations that surprisingly remain very poorly studied. Understanding the convergent and specific adaptations of bone to weight bearing in taxa with various morphologies, sizes, habitats and locomotor behaviours is essential to understand how bone responds to biomechanical constraints. In palaeontology, it will allow determining how giant fossil animals could move and support their weight. The study of graviportality provides an ideal case-study to analyse form-function relationship in a macro-evolutionary context.
GRAVIBONE proposes a broad and modern comparative investigation of the biomechanical adaptations of the outer and inner bone anatomy of long bones observable in different modern and fossil taxa that have converged on graviportality. It combines various approaches using recently developed powerful methods and tools (notably the innovative integration of the whole 3D external and internal bone anatomy in biomechanical modelling) and uses these in an explicit phylogenetic context. Characterizing the various adaptive traits observed in extant taxa and understanding the link between specific isolated microanatomical, morphological and mechanical parameters will enable to: a) define degrees/types of adaptations to graviportality, b) make palaeoecological and paleofunctional inferences, and c) explain adaptations to graviportality in amniote evolutionary history. This new and highly integrative approach will increase our knowledge on the adaptation of the vertebrate skeleton and thereby of the organisms, to environmental demands.
Summary
Heavy animals, said to be graviportal, are under strong mechanical constraints. Their skeleton, notably their limb bones, show convergent morpho-functional adaptations that surprisingly remain very poorly studied. Understanding the convergent and specific adaptations of bone to weight bearing in taxa with various morphologies, sizes, habitats and locomotor behaviours is essential to understand how bone responds to biomechanical constraints. In palaeontology, it will allow determining how giant fossil animals could move and support their weight. The study of graviportality provides an ideal case-study to analyse form-function relationship in a macro-evolutionary context.
GRAVIBONE proposes a broad and modern comparative investigation of the biomechanical adaptations of the outer and inner bone anatomy of long bones observable in different modern and fossil taxa that have converged on graviportality. It combines various approaches using recently developed powerful methods and tools (notably the innovative integration of the whole 3D external and internal bone anatomy in biomechanical modelling) and uses these in an explicit phylogenetic context. Characterizing the various adaptive traits observed in extant taxa and understanding the link between specific isolated microanatomical, morphological and mechanical parameters will enable to: a) define degrees/types of adaptations to graviportality, b) make palaeoecological and paleofunctional inferences, and c) explain adaptations to graviportality in amniote evolutionary history. This new and highly integrative approach will increase our knowledge on the adaptation of the vertebrate skeleton and thereby of the organisms, to environmental demands.
Max ERC Funding
1 082 450 €
Duration
Start date: 2017-04-01, End date: 2022-03-31