Project acronym ALLEGRO
Project unrAvelLing sLow modE travelinG and tRaffic: with innOvative data to a new transportation and traffic theory for pedestrians and bicycles
Researcher (PI) Serge Hoogendoorn
Host Institution (HI) TECHNISCHE UNIVERSITEIT DELFT
Call Details Advanced Grant (AdG), SH3, ERC-2014-ADG
Summary A major challenge in contemporary traffic and transportation theory is having a comprehensive understanding of pedestrians and cyclists behaviour. This is notoriously hard to observe, since sensors providing abundant and detailed information about key variables characterising this behaviour have not been available until very recently. The behaviour is also far more complex than that of the much better understood fast mode. This is due to the many degrees of freedom in decision-making, the interactions among slow traffic participants that are more involved and far less guided by traffic rules and regulations than those between car-drivers, and the many fascinating but complex phenomena in slow traffic flows (self-organised patterns, turbulence, spontaneous phase transitions, herding, etc.) that are very hard to predict accurately.
With slow traffic modes gaining ground in terms of mode share in many cities, lack of empirical insights, behavioural theories, predictively valid analytical and simulation models, and tools to support planning, design, management and control is posing a major societal problem as well: examples of major accidents due to bad planning, organisation and management of events are manifold, as are locations where safety of slow modes is a serious issue due to interactions with fast modes.
This programme is geared towards establishing a comprehensive theory of slow mode traffic behaviour, considering the different behavioural levels relevant for understanding, reproducing and predicting slow mode traffic flows in cities. The levels deal with walking and cycling operations, activity scheduling and travel behaviour, and knowledge representation and learning. Major scientific breakthroughs are expected at each of these levels, in terms of theory and modelling, by using innovative (big) data collection and experimentation, analysis and fusion techniques, including social media data analytics, using augmented reality, and remote and crowd sensing.
Summary
A major challenge in contemporary traffic and transportation theory is having a comprehensive understanding of pedestrians and cyclists behaviour. This is notoriously hard to observe, since sensors providing abundant and detailed information about key variables characterising this behaviour have not been available until very recently. The behaviour is also far more complex than that of the much better understood fast mode. This is due to the many degrees of freedom in decision-making, the interactions among slow traffic participants that are more involved and far less guided by traffic rules and regulations than those between car-drivers, and the many fascinating but complex phenomena in slow traffic flows (self-organised patterns, turbulence, spontaneous phase transitions, herding, etc.) that are very hard to predict accurately.
With slow traffic modes gaining ground in terms of mode share in many cities, lack of empirical insights, behavioural theories, predictively valid analytical and simulation models, and tools to support planning, design, management and control is posing a major societal problem as well: examples of major accidents due to bad planning, organisation and management of events are manifold, as are locations where safety of slow modes is a serious issue due to interactions with fast modes.
This programme is geared towards establishing a comprehensive theory of slow mode traffic behaviour, considering the different behavioural levels relevant for understanding, reproducing and predicting slow mode traffic flows in cities. The levels deal with walking and cycling operations, activity scheduling and travel behaviour, and knowledge representation and learning. Major scientific breakthroughs are expected at each of these levels, in terms of theory and modelling, by using innovative (big) data collection and experimentation, analysis and fusion techniques, including social media data analytics, using augmented reality, and remote and crowd sensing.
Max ERC Funding
2 458 700 €
Duration
Start date: 2015-11-01, End date: 2020-10-31
Project acronym ARTimmune
Project Programmable ARTificial immune systems to fight cancer
Researcher (PI) Carl FIGDOR
Host Institution (HI) STICHTING KATHOLIEKE UNIVERSITEIT
Call Details Advanced Grant (AdG), LS7, ERC-2018-ADG
Summary Immunotherapy has entered centre stage as a novel treatment modality for cancer. Notwithstanding this major step forward, toxicity and immunosuppression remain major obstacles, and illustrate the pressing need for more powerful and specific immunotherapies against cancer. To overcome these roadblocks, in ARTimmune, I propose to follow a radically different approach by developing local rather than systemic immunotherapies. Taking advantage of the architecture of a lymph node (LN), I aim to design fully synthetic immune niches to locally instruct immune cell function. I hypothesize that programmable synthetic immune niches, when injected next to a tumour, will act as local powerhouses to generate bursts of cytotoxic T cells for tumour destruction, without toxic side effects. Single cell transcriptomics on LN, obtained from patients that are vaccinated against cancer, will provide unique insight in communication within immune cell clusters and provide a blueprint for the intelligent design of synthetic immune niches. Chemical tools will be used to build branched polymeric structures decorated with immunomodulating molecules to mimic LN architecture. These will be injected, mixed with sponge-like scaffolds to provide porosity needed for immune cell infiltration. Programming of immune cell function will be accomplished by in vivo targeting- and proteolytic activation- of immunomodulators for fine-tuning, and to extend the life span of these local powerhouses. The innovative character of ARTimmune comes from: 1) novel fundamental immunological insight in complex communication within LN cell clusters, 2) a revolutionary new approach in immunotherapy, by the development of 3) injectable- and 4) programmable- synthetic immune niches by state-of-the-art chemical technology. When successful, it will revolutionize cancer immunotherapy, moving from maximal tolerable dose systemic treatment with significant toxicity to local low dose treatment in the direct vicinity of a tumour
Summary
Immunotherapy has entered centre stage as a novel treatment modality for cancer. Notwithstanding this major step forward, toxicity and immunosuppression remain major obstacles, and illustrate the pressing need for more powerful and specific immunotherapies against cancer. To overcome these roadblocks, in ARTimmune, I propose to follow a radically different approach by developing local rather than systemic immunotherapies. Taking advantage of the architecture of a lymph node (LN), I aim to design fully synthetic immune niches to locally instruct immune cell function. I hypothesize that programmable synthetic immune niches, when injected next to a tumour, will act as local powerhouses to generate bursts of cytotoxic T cells for tumour destruction, without toxic side effects. Single cell transcriptomics on LN, obtained from patients that are vaccinated against cancer, will provide unique insight in communication within immune cell clusters and provide a blueprint for the intelligent design of synthetic immune niches. Chemical tools will be used to build branched polymeric structures decorated with immunomodulating molecules to mimic LN architecture. These will be injected, mixed with sponge-like scaffolds to provide porosity needed for immune cell infiltration. Programming of immune cell function will be accomplished by in vivo targeting- and proteolytic activation- of immunomodulators for fine-tuning, and to extend the life span of these local powerhouses. The innovative character of ARTimmune comes from: 1) novel fundamental immunological insight in complex communication within LN cell clusters, 2) a revolutionary new approach in immunotherapy, by the development of 3) injectable- and 4) programmable- synthetic immune niches by state-of-the-art chemical technology. When successful, it will revolutionize cancer immunotherapy, moving from maximal tolerable dose systemic treatment with significant toxicity to local low dose treatment in the direct vicinity of a tumour
Max ERC Funding
2 500 000 €
Duration
Start date: 2019-11-01, End date: 2024-10-31
Project acronym ATTACK
Project Pressured to Attack: How Carrying-Capacity Stress Creates and Shapes Intergroup Conflict
Researcher (PI) Carsten DE DREU
Host Institution (HI) UNIVERSITEIT LEIDEN
Call Details Advanced Grant (AdG), SH3, ERC-2017-ADG
Summary Throughout history, what has been causing tremendous suffering is groups of people fighting each other. While behavioral science research has advanced our understanding of such intergroup conflict, it has exclusively focused on micro-level processes within and between groups at conflict. Disciplines that employ a more historical perspective like climate studies or political geography report that macro-level pressures due to changes in climate or economic scarcity can go along with social unrest and wars. How do these macro-level pressures relate to micro-level processes? Do they both occur independently, or do macro-level pressures trigger micro-level processes that cause intergroup conflict? And if so, which micro-level processes are triggered, and how?
With unavoidable signs of climate change and increasing resource scarcities, answers to these questions are urgently needed. Here I propose carrying-capacity stress (CCS) as the missing link between macro-level pressures and micro-level processes. A group experiences CCS when its resources do not suffice to maintain its functionality. CCS is a function of macro-level pressures and creates intergroup conflict because it impacts micro-level motivation to contribute to one’s group’s fighting capacity and shapes the coordination of individual contributions to out-group aggression through emergent norms, communication and leadership.
To test these propositions I develop a parametric model of CCS that is amenable to measurement and experimentation, and use techniques used in my work on conflict and cooperation: Meta-analyses and time-series analysis of macro-level historical data; experiments on intergroup conflict; and measurement of neuro-hormonal correlates of cooperation and conflict. In combination, this project provides novel multi-level conflict theory that integrates macro-level discoveries in climate research and political geography with micro-level processes uncovered in the biobehavioral sciences
Summary
Throughout history, what has been causing tremendous suffering is groups of people fighting each other. While behavioral science research has advanced our understanding of such intergroup conflict, it has exclusively focused on micro-level processes within and between groups at conflict. Disciplines that employ a more historical perspective like climate studies or political geography report that macro-level pressures due to changes in climate or economic scarcity can go along with social unrest and wars. How do these macro-level pressures relate to micro-level processes? Do they both occur independently, or do macro-level pressures trigger micro-level processes that cause intergroup conflict? And if so, which micro-level processes are triggered, and how?
With unavoidable signs of climate change and increasing resource scarcities, answers to these questions are urgently needed. Here I propose carrying-capacity stress (CCS) as the missing link between macro-level pressures and micro-level processes. A group experiences CCS when its resources do not suffice to maintain its functionality. CCS is a function of macro-level pressures and creates intergroup conflict because it impacts micro-level motivation to contribute to one’s group’s fighting capacity and shapes the coordination of individual contributions to out-group aggression through emergent norms, communication and leadership.
To test these propositions I develop a parametric model of CCS that is amenable to measurement and experimentation, and use techniques used in my work on conflict and cooperation: Meta-analyses and time-series analysis of macro-level historical data; experiments on intergroup conflict; and measurement of neuro-hormonal correlates of cooperation and conflict. In combination, this project provides novel multi-level conflict theory that integrates macro-level discoveries in climate research and political geography with micro-level processes uncovered in the biobehavioral sciences
Max ERC Funding
2 490 383 €
Duration
Start date: 2018-08-01, End date: 2023-07-31
Project acronym AUTHORITARIANGLOBAL
Project Authoritarianism in a Global Age: Controlling Information and Communication, Association and People Movement
Researcher (PI) Marlies Glasius
Host Institution (HI) UNIVERSITEIT VAN AMSTERDAM
Call Details Advanced Grant (AdG), SH2, ERC-2012-ADG_20120411
Summary The overarching research question of this project is: how is authoritarian rule affected by and responding to globalisation of (a) information and communication, (b) association, and (c) people movement? The wholly unpredicted series of revolts that recently spread across the Arab world suggests that the nature and sustainability of contemporary authoritarian rule are not well-understood. Openness to global ICT and media, international NGOs, and inflow and outflow of people have thrown up new challenges for authoritarian rulers in terms of how to control citizens. This project investigates changes in both the nature and the sustainability of authoritarian rule in relation to the erosion of decision-making autonomy at the state level posited by globalisation theorists.
In four sub-projects, this project will investigate:
1. Whether, how and to what extent globalisation of information and communication, association, and people movement affect authoritarian persistence (longitudinal quantitative study, 1970-2011)
2. How, i.e. with what policy mechanisms, authoritarian states respond to globalisation of information and communication, association, and people movement (qualitative multi-sited studies relating to Belarus, China, Iran and Zimbabwe)
3. How to understand the phenomenon of subnational authoritarianism in its engagement with the democratic state and the wider world in relation to information and communication, association, and people movement (mixed method subnational studies of states within India and Mexico)
4. What authoritarianism is in a global age: reconsidering authoritarianism’s defining characteristics of low accountability and high coercion, and whether these still relate exclusively to statehood (theory study)
The project will transcend the theoretical and empirical separation between globalisation studies (which have neglected authoritarian contexts) and authoritarianism studies(which have taken relatively little notice of effects of globalisation)
Summary
The overarching research question of this project is: how is authoritarian rule affected by and responding to globalisation of (a) information and communication, (b) association, and (c) people movement? The wholly unpredicted series of revolts that recently spread across the Arab world suggests that the nature and sustainability of contemporary authoritarian rule are not well-understood. Openness to global ICT and media, international NGOs, and inflow and outflow of people have thrown up new challenges for authoritarian rulers in terms of how to control citizens. This project investigates changes in both the nature and the sustainability of authoritarian rule in relation to the erosion of decision-making autonomy at the state level posited by globalisation theorists.
In four sub-projects, this project will investigate:
1. Whether, how and to what extent globalisation of information and communication, association, and people movement affect authoritarian persistence (longitudinal quantitative study, 1970-2011)
2. How, i.e. with what policy mechanisms, authoritarian states respond to globalisation of information and communication, association, and people movement (qualitative multi-sited studies relating to Belarus, China, Iran and Zimbabwe)
3. How to understand the phenomenon of subnational authoritarianism in its engagement with the democratic state and the wider world in relation to information and communication, association, and people movement (mixed method subnational studies of states within India and Mexico)
4. What authoritarianism is in a global age: reconsidering authoritarianism’s defining characteristics of low accountability and high coercion, and whether these still relate exclusively to statehood (theory study)
The project will transcend the theoretical and empirical separation between globalisation studies (which have neglected authoritarian contexts) and authoritarianism studies(which have taken relatively little notice of effects of globalisation)
Max ERC Funding
2 451 179 €
Duration
Start date: 2013-10-01, End date: 2019-02-28
Project acronym BAM
Project Becoming A Minority
Researcher (PI) Maurice CRUL
Host Institution (HI) STICHTING VU
Call Details Advanced Grant (AdG), SH3, ERC-2016-ADG
Summary In the last forty years, researchers in the Field of Migration and Ethnic Studies looked at the integration of migrants and their descendants. Concepts, methodological tools and theoretical frameworks have been developed to measure and predict integration outcomes both across different ethnic groups and in comparison with people of native descent. But are we also looking into the actual integration of the receiving group of native ‘white’ descent in city contexts where they have become a numerical minority themselves? In cities like Amsterdam, now only one in three youngsters under age fifteen is of native descent. This situation, referred to as a majority-minority context, is a new phenomenon in Western Europe and it presents itself as one of the most important societal and psychological transformations of our time. I argue that the field of migration and ethnic studies is stagnating because of the one-sided focus on migrants and their children. This is even more urgent given the increased ant-immigrant vote. These pressing scientific and societal reasons pushed me to develop the project BAM (Becoming A Minority). The project will be executed in three harbor cities, Rotterdam, Antwerp and Malmö, and three service sector cities, Amsterdam, Frankfurt and Vienna. BAM consists of 5 subprojects: (1) A meta-analysis of secondary data on people of native ‘white’ descent in the six research sites; (2) A newly developed survey for the target group; (3) An analysis of critical circumstances of encounter that trigger either positive or rather negative responses to increased ethnic diversity (4) Experimental diversity labs to test under which circumstances people will change their attitudes or their actions towards increased ethnic diversity; (5) The formulation of a new theory of integration that includes the changed position of the group of native ‘white’ descent as an important actor.
Summary
In the last forty years, researchers in the Field of Migration and Ethnic Studies looked at the integration of migrants and their descendants. Concepts, methodological tools and theoretical frameworks have been developed to measure and predict integration outcomes both across different ethnic groups and in comparison with people of native descent. But are we also looking into the actual integration of the receiving group of native ‘white’ descent in city contexts where they have become a numerical minority themselves? In cities like Amsterdam, now only one in three youngsters under age fifteen is of native descent. This situation, referred to as a majority-minority context, is a new phenomenon in Western Europe and it presents itself as one of the most important societal and psychological transformations of our time. I argue that the field of migration and ethnic studies is stagnating because of the one-sided focus on migrants and their children. This is even more urgent given the increased ant-immigrant vote. These pressing scientific and societal reasons pushed me to develop the project BAM (Becoming A Minority). The project will be executed in three harbor cities, Rotterdam, Antwerp and Malmö, and three service sector cities, Amsterdam, Frankfurt and Vienna. BAM consists of 5 subprojects: (1) A meta-analysis of secondary data on people of native ‘white’ descent in the six research sites; (2) A newly developed survey for the target group; (3) An analysis of critical circumstances of encounter that trigger either positive or rather negative responses to increased ethnic diversity (4) Experimental diversity labs to test under which circumstances people will change their attitudes or their actions towards increased ethnic diversity; (5) The formulation of a new theory of integration that includes the changed position of the group of native ‘white’ descent as an important actor.
Max ERC Funding
2 499 714 €
Duration
Start date: 2017-11-01, End date: 2022-10-31
Project acronym BIOMECHTOOLS
Project Biomechanical diagnostic, pre-planning and outcome tools to improve musculoskeletal surgery
Researcher (PI) Nicolaas Verdonschot
Host Institution (HI) STICHTING KATHOLIEKE UNIVERSITEIT
Call Details Advanced Grant (AdG), LS7, ERC-2012-ADG_20120314
Summary The aetiology of many musculoskeletal (MS) diseases is related to biomechanical factors. However, the tools to assess the biomechanical condition of patients used by clinicians and researchers are often crude and subjective leading to non-optimal patient analyses and care. In this project innovations related to imaging, sensor technology and biomechanical modelling are utilized to generate versatile, accurate and objective methods to quantify the (pathological) MS condition of the lower extremity of patients in a unique manner. The project will produce advanced diagnostic, pre-planning and outcome tools which allow clinicians and researchers for detailed biomechanical analysis about abnormal tissue deformations, pathological loading of the joints, abnormal stresses in the hard and soft tissues, and aberrant joint kinematics.
The key objectives of this proposal are:
1) Develop and validate image-based 3-D volumetric elastographic diagnostic methods that can quantify normal and pathological conditions under dynamic loading and which can be linked to biomechanical modelling tools.
2) Create an ultrasound (US)-based system to assess internal joint kinematics which can be used as a diagnostic tool for clinicians and researchers and is a validation tool for biomechanical modelling.
3) Generate and validate an ambulant functional (force and kinematic) diagnostic system which is easy to use and which can be used to provide input data for biomechanical models.
4) Create and validate a new modelling approach that integrates muscle-models with finite element models at a highly personalized level.
5) Generate biomechanical models which have personalized mechanical properties of the hard and soft tissues.
6) Demonstrate the applicability of the personalized diagnostic and pre-planning platform by application to healthy individuals and patient subjects.
Support from the ERC will open new research fields related to biomechanical patient assessment and modeling of MS pathologies.
Summary
The aetiology of many musculoskeletal (MS) diseases is related to biomechanical factors. However, the tools to assess the biomechanical condition of patients used by clinicians and researchers are often crude and subjective leading to non-optimal patient analyses and care. In this project innovations related to imaging, sensor technology and biomechanical modelling are utilized to generate versatile, accurate and objective methods to quantify the (pathological) MS condition of the lower extremity of patients in a unique manner. The project will produce advanced diagnostic, pre-planning and outcome tools which allow clinicians and researchers for detailed biomechanical analysis about abnormal tissue deformations, pathological loading of the joints, abnormal stresses in the hard and soft tissues, and aberrant joint kinematics.
The key objectives of this proposal are:
1) Develop and validate image-based 3-D volumetric elastographic diagnostic methods that can quantify normal and pathological conditions under dynamic loading and which can be linked to biomechanical modelling tools.
2) Create an ultrasound (US)-based system to assess internal joint kinematics which can be used as a diagnostic tool for clinicians and researchers and is a validation tool for biomechanical modelling.
3) Generate and validate an ambulant functional (force and kinematic) diagnostic system which is easy to use and which can be used to provide input data for biomechanical models.
4) Create and validate a new modelling approach that integrates muscle-models with finite element models at a highly personalized level.
5) Generate biomechanical models which have personalized mechanical properties of the hard and soft tissues.
6) Demonstrate the applicability of the personalized diagnostic and pre-planning platform by application to healthy individuals and patient subjects.
Support from the ERC will open new research fields related to biomechanical patient assessment and modeling of MS pathologies.
Max ERC Funding
2 456 400 €
Duration
Start date: 2013-05-01, End date: 2018-04-30
Project acronym BIOSPACE
Project Monitoring Biodiversity from Space
Researcher (PI) Andrew Kerr Skidmore
Host Institution (HI) UNIVERSITEIT TWENTE
Call Details Advanced Grant (AdG), SH2, ERC-2018-ADG
Summary Life, with all its diversity, is in crisis. As humans increasingly encroach on biologically complex semi- natural landscapes, no organism, place or ecological function remains unaffected. While all 196 parties (195 countries plus the European Union) to the UN Convention on Biodiversity (CBD) have agreed to monitor the state of biodiversity, the currently available methods to do so leave much to be desired. Traditional monitoring involves the field observation of species by trained specialists, aided by skilled volunteers, whose expertise is restricted to specific biotic groupings. In a process that is both time consuming and inconsistent across time and space, botanists identify and record the presence of plant species and ornithologists the bird biota, resulting in 'unpopular' biotic groups such as fungi, bacteria and insects being under-observed or escaping identification altogether. In this project, a fundamentally different approach to terrestrial biodiversity monitoring couples next generation satellite remote sensing with environmental DNA (eDNA) profiling, complemented where available by legacy human-observed datasets. Satellite remote sensing is able to survey the environment as a single, continuous, fine-resolution map, while eDNA profiling can rapidly quantify much greater taxonomical and functional breadth and depth than human field observation. This project combines, for the first time, these two powerful, cutting-edge techniques for monitoring biodiversity at the global level in a consistent manner. Following from this, another key innovation will be the deepening of our scientific understanding of how biodiversity is impacted by anthropogenic pressure as well as by natural environmental gradients. In concert, these scientific developments will enable the accurate and fine grain monitoring of biodiversity from space – a ground-breaking contribution to the quest to meet the UN Sustainable Development Goals and CBD Aichi targets.
Summary
Life, with all its diversity, is in crisis. As humans increasingly encroach on biologically complex semi- natural landscapes, no organism, place or ecological function remains unaffected. While all 196 parties (195 countries plus the European Union) to the UN Convention on Biodiversity (CBD) have agreed to monitor the state of biodiversity, the currently available methods to do so leave much to be desired. Traditional monitoring involves the field observation of species by trained specialists, aided by skilled volunteers, whose expertise is restricted to specific biotic groupings. In a process that is both time consuming and inconsistent across time and space, botanists identify and record the presence of plant species and ornithologists the bird biota, resulting in 'unpopular' biotic groups such as fungi, bacteria and insects being under-observed or escaping identification altogether. In this project, a fundamentally different approach to terrestrial biodiversity monitoring couples next generation satellite remote sensing with environmental DNA (eDNA) profiling, complemented where available by legacy human-observed datasets. Satellite remote sensing is able to survey the environment as a single, continuous, fine-resolution map, while eDNA profiling can rapidly quantify much greater taxonomical and functional breadth and depth than human field observation. This project combines, for the first time, these two powerful, cutting-edge techniques for monitoring biodiversity at the global level in a consistent manner. Following from this, another key innovation will be the deepening of our scientific understanding of how biodiversity is impacted by anthropogenic pressure as well as by natural environmental gradients. In concert, these scientific developments will enable the accurate and fine grain monitoring of biodiversity from space – a ground-breaking contribution to the quest to meet the UN Sustainable Development Goals and CBD Aichi targets.
Max ERC Funding
2 470 315 €
Duration
Start date: 2019-09-01, End date: 2024-08-31
Project acronym ChemicalYouth
Project What chemicals do for youths in their everyday lives
Researcher (PI) Anita Petra Hardon
Host Institution (HI) UNIVERSITEIT VAN AMSTERDAM
Call Details Advanced Grant (AdG), SH2, ERC-2012-ADG_20120411
Summary The everyday lives of contemporary youths are awash with chemicals and pharmaceutical compounds to boost pleasure, moods, sexual performance, vitality, appearance and health. Nevertheless, most studies of chemical use among young people have focused on the abuse of specific recreational drugs and their role within deviant youth sub-cultures. Instead of explaining drug abuse with the purpose of controlling it, this project aims to examine the pervasive use of chemicals from the perspectives of youths themselves. It aims to understand what chemical and pharmaceutical substances, and not only illicit narcotics, ‘do’ for youths. How are chemicals a part of their everyday lives? What role do they play in calming their fears or in achieving their dreams and aspirations? How can we understand the ways in which chemicals affect their bodies and minds?
The theoretical innovation promised by this project lies in its combining of disciplines – most notably medical anthropology, science and technology studies and youth studies – to formulate a new groundbreaking framework for understanding the complex sociality of chemicals in youths’ everyday lives. The framework will have both scientific and societal impact.
Ethnographic research will be conducted in four medium-sized cities: Marseille in France, Amsterdam in the Netherlands, Makassar in Indonesia, and Batangas in the Philippines.
Summary
The everyday lives of contemporary youths are awash with chemicals and pharmaceutical compounds to boost pleasure, moods, sexual performance, vitality, appearance and health. Nevertheless, most studies of chemical use among young people have focused on the abuse of specific recreational drugs and their role within deviant youth sub-cultures. Instead of explaining drug abuse with the purpose of controlling it, this project aims to examine the pervasive use of chemicals from the perspectives of youths themselves. It aims to understand what chemical and pharmaceutical substances, and not only illicit narcotics, ‘do’ for youths. How are chemicals a part of their everyday lives? What role do they play in calming their fears or in achieving their dreams and aspirations? How can we understand the ways in which chemicals affect their bodies and minds?
The theoretical innovation promised by this project lies in its combining of disciplines – most notably medical anthropology, science and technology studies and youth studies – to formulate a new groundbreaking framework for understanding the complex sociality of chemicals in youths’ everyday lives. The framework will have both scientific and societal impact.
Ethnographic research will be conducted in four medium-sized cities: Marseille in France, Amsterdam in the Netherlands, Makassar in Indonesia, and Batangas in the Philippines.
Max ERC Funding
2 489 967 €
Duration
Start date: 2013-06-01, End date: 2018-05-31
Project acronym CODEX
Project Decoding Domesticate DNA in Archaeological Bone and Manuscripts
Researcher (PI) Daniel Gerard Bradley
Host Institution (HI) THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Call Details Advanced Grant (AdG), SH6, ERC-2011-ADG_20110406
Summary Through animal domestication humans profoundly altered their relationship with nature, controlling the breeding of their major food sources for material, social or symbolic profit. Understanding this complex process is a compelling research aim. There is a need to develop new high-resolution genetic tools to put flesh on the bones of this two-millenium long transition. These will take advantage of very recent advances: targeted next generation DNA sequencing, high throughput screening of expertly provenanced archaeological samples, and emerging knowledge of modern cattle, sheep and goat genome science plus their genetic geographies. Combining these, this proposal will develop an ancient DNA data matrix that will be unparalleled in archaeological science. These data will unlock the key genetic changes that accompany the domestic state and the breeding structures that are a consequence of human management. It will also identify the wild and proto-domestic populations that later herds emerge from. A more precise geography and timing of the key changes will enable richer contextualising inform our assessement of why these changes take place. The 10,000 year matrix for each species will function as a standard spatiotemporal reference grid on which any subsequent bone or animal artefact may be placed i.e. via genetic postcoding. Exceptional discontinuities in the matrix will highlight points of strong historical interest such as the emergence of new trade networks, migrations and periods of economic turbulence - perhaps driven by climate fluctuations or plagues. The final work objectives will focus on diachronic sample assemblages selected to have particular import for both historical events and transitions in material culture. For example, manuscript vellum samples will give a uniquely dated series that will enable correlation of genetic change with historical studies of the timing and impact of past animal plagues (e.g. in C 14th and C 18th Europe).
Summary
Through animal domestication humans profoundly altered their relationship with nature, controlling the breeding of their major food sources for material, social or symbolic profit. Understanding this complex process is a compelling research aim. There is a need to develop new high-resolution genetic tools to put flesh on the bones of this two-millenium long transition. These will take advantage of very recent advances: targeted next generation DNA sequencing, high throughput screening of expertly provenanced archaeological samples, and emerging knowledge of modern cattle, sheep and goat genome science plus their genetic geographies. Combining these, this proposal will develop an ancient DNA data matrix that will be unparalleled in archaeological science. These data will unlock the key genetic changes that accompany the domestic state and the breeding structures that are a consequence of human management. It will also identify the wild and proto-domestic populations that later herds emerge from. A more precise geography and timing of the key changes will enable richer contextualising inform our assessement of why these changes take place. The 10,000 year matrix for each species will function as a standard spatiotemporal reference grid on which any subsequent bone or animal artefact may be placed i.e. via genetic postcoding. Exceptional discontinuities in the matrix will highlight points of strong historical interest such as the emergence of new trade networks, migrations and periods of economic turbulence - perhaps driven by climate fluctuations or plagues. The final work objectives will focus on diachronic sample assemblages selected to have particular import for both historical events and transitions in material culture. For example, manuscript vellum samples will give a uniquely dated series that will enable correlation of genetic change with historical studies of the timing and impact of past animal plagues (e.g. in C 14th and C 18th Europe).
Max ERC Funding
2 499 693 €
Duration
Start date: 2012-07-01, End date: 2018-06-30
Project acronym COLUMNARCODECRACKING
Project Cracking the columnar-level code in the visual hierarchy: Ultra high-field functional MRI, neuro-cognitive modelling and high-resolution brain-computer interfaces
Researcher (PI) Rainer Goebel
Host Institution (HI) UNIVERSITEIT MAASTRICHT
Call Details Advanced Grant (AdG), SH4, ERC-2010-AdG_20100407
Summary "Recent developments of high-field functional magnetic resonance imaging (fMRI) have advanced the level of functional detail to sub-millimetre spatial resolution. This is of critical importance because in the mammalian cortex, small functional cortical patches appear to constitute fundamental units of brain function. These functional units are often organized as ""cortical columns"" that contain clusters of neurons with similar functional preferences. The present project will investigate what ""features"" are coded by functional “columnar-level” units in the visual cortex, how represented entities can be decoded from distributed activity patterns, and how modelled intra- and inter-areal connections between feature representations enable neuro-cognitive computations. The research of this project strives towards a new level of insight in the functional organization of the human brain: Instead of describing observed fMRI activity at the level of specialized brain areas, the focus will be shifted towards the content coded within brain regions. The project investigates columnar-level coding in three cross-fertilising sub-projects. In the first sub-project, sophisticated experimental designs, ultra high-field fMRI and advanced data analyses will be combined to unravel columnar-level feature representations and the entities represented by distributed patterns at different levels of the visual hierarchy. In the second sub-project, a large-scale neural network model will be developed with the major goal to integrate measured columnar-level representations in a new theory of invariant object recognition and visual attention. In the third sub-project, high-resolution Brain Computer Interfaces (hr-BCIs) will be created that are based on information extracted from columnar-level representations. The hr-BCIs will implement highly content-specific neurofeedback tools for therapeutic treatment, and advanced communication devices for patients with severe motor impairments."
Summary
"Recent developments of high-field functional magnetic resonance imaging (fMRI) have advanced the level of functional detail to sub-millimetre spatial resolution. This is of critical importance because in the mammalian cortex, small functional cortical patches appear to constitute fundamental units of brain function. These functional units are often organized as ""cortical columns"" that contain clusters of neurons with similar functional preferences. The present project will investigate what ""features"" are coded by functional “columnar-level” units in the visual cortex, how represented entities can be decoded from distributed activity patterns, and how modelled intra- and inter-areal connections between feature representations enable neuro-cognitive computations. The research of this project strives towards a new level of insight in the functional organization of the human brain: Instead of describing observed fMRI activity at the level of specialized brain areas, the focus will be shifted towards the content coded within brain regions. The project investigates columnar-level coding in three cross-fertilising sub-projects. In the first sub-project, sophisticated experimental designs, ultra high-field fMRI and advanced data analyses will be combined to unravel columnar-level feature representations and the entities represented by distributed patterns at different levels of the visual hierarchy. In the second sub-project, a large-scale neural network model will be developed with the major goal to integrate measured columnar-level representations in a new theory of invariant object recognition and visual attention. In the third sub-project, high-resolution Brain Computer Interfaces (hr-BCIs) will be created that are based on information extracted from columnar-level representations. The hr-BCIs will implement highly content-specific neurofeedback tools for therapeutic treatment, and advanced communication devices for patients with severe motor impairments."
Max ERC Funding
2 473 381 €
Duration
Start date: 2011-05-01, End date: 2016-04-30
