Project acronym ChronHib
Project Chronologicon Hibernicum – A Probabilistic Chronological Framework for Dating Early Irish Language Developments and Literature
Researcher (PI) David Stifter
Host Institution (HI) NATIONAL UNIVERSITY OF IRELAND MAYNOOTH
Country Ireland
Call Details Consolidator Grant (CoG), SH4, ERC-2014-CoG
Summary Early Medieval Irish literature (7th–10th centuries) is vast in extent and rich in genres, but owing to its mostly anonymous transmission, for most texts the precise time and circumstances of composition are unknown. Unless where texts contain historical references, the only clues for a rough chronological positioning of the texts are to be found in their linguistic peculiarities. Phonology, morphology, syntax and the lexicon of the Irish language changed considerably from Early Old Irish (7th c.) into Middle Irish (c. 10th–12th centuries). However, only the relative sequence of changes is well understood; for most sound changes very few narrow dates have been proposed so far.
It is the aim of Chronologicon Hibernicum to find a common solution for both problems: through the linguistic profiling of externally dated texts (esp. annalistic writing and sources with a clear historical anchorage) and through serialising the emerging linguistic and chronological data, progress will be made in assigning dates to the linguistic changes. Groundbreakingly, this will be done by using statistical methods for the seriation of the data, and for estimating dates using Bayesian inference.
The resultant information will then be used to find new dates for hitherto undated texts. On this basis, a much tighter chronological framework for the developments of the Early Medieval Irish language will be created. In a further step it will be possible to arrive at a better chronological description of medieval Irish literature as a whole, which will have repercussions on the study of the history and cultural and intellectual environment of medieval Ireland and on its connections with the wider world.
The data collected and analysed in this project will form the database Chronologicon Hibernicum which will serve as the authoritative guideline and reference point for the linguistic dating of Irish texts. In the future, the methodology will be transferable to other languages.
Summary
Early Medieval Irish literature (7th–10th centuries) is vast in extent and rich in genres, but owing to its mostly anonymous transmission, for most texts the precise time and circumstances of composition are unknown. Unless where texts contain historical references, the only clues for a rough chronological positioning of the texts are to be found in their linguistic peculiarities. Phonology, morphology, syntax and the lexicon of the Irish language changed considerably from Early Old Irish (7th c.) into Middle Irish (c. 10th–12th centuries). However, only the relative sequence of changes is well understood; for most sound changes very few narrow dates have been proposed so far.
It is the aim of Chronologicon Hibernicum to find a common solution for both problems: through the linguistic profiling of externally dated texts (esp. annalistic writing and sources with a clear historical anchorage) and through serialising the emerging linguistic and chronological data, progress will be made in assigning dates to the linguistic changes. Groundbreakingly, this will be done by using statistical methods for the seriation of the data, and for estimating dates using Bayesian inference.
The resultant information will then be used to find new dates for hitherto undated texts. On this basis, a much tighter chronological framework for the developments of the Early Medieval Irish language will be created. In a further step it will be possible to arrive at a better chronological description of medieval Irish literature as a whole, which will have repercussions on the study of the history and cultural and intellectual environment of medieval Ireland and on its connections with the wider world.
The data collected and analysed in this project will form the database Chronologicon Hibernicum which will serve as the authoritative guideline and reference point for the linguistic dating of Irish texts. In the future, the methodology will be transferable to other languages.
Max ERC Funding
1 804 230 €
Duration
Start date: 2015-09-01, End date: 2021-04-30
Project acronym ExpoBiome
Project Deciphering the impact of exposures from the gut microbiome-derived molecular complex in human health and disease
Researcher (PI) Paul WILMES
Host Institution (HI) UNIVERSITE DU LUXEMBOURG
Country Luxembourg
Call Details Consolidator Grant (CoG), LS2, ERC-2019-COG
Summary The human gut microbiome is a complex ecosystem, which contributes essential functions to human physiology. Changes to the microbiome are associated with several chronic diseases characterised by inflammation, including neurodegenerative and autoimmune diseases. Microbiome-derived effector molecules comprising nucleic acids, (poly)peptides and metabolites are present at high levels in the gut but have so far eluded systematic study. This gap in knowledge is limiting mechanistic understanding of the microbiome’s functional impact on chronic diseases such as Parkinson’s disease (PD) and rheumatoid arthritis (RA). Here, I will for the first time integrate a combination of advanced high-resolution methodologies to comprehensively identify the constituents of this molecular complex and their impact on the human immune system. First, I will perform a quantitative, integrated multi-omic analysis on microbiome samples collected from healthy individuals and patients with newly diagnosed PD or RA. I will integrate and analyse the data using a newly developed knowledge base. Using contextualised prior knowledge (ExpoBiome Map) and machine learning methods, I will identify microbial molecules associated with condition-specific immunophenotypes. Second, I will validate and track the biomarker signature during a model clinical intervention (therapeutic fasting) to predict treatment outcomes. Third, microbes and molecules will be screened in personalised HuMiX gut-on-chip models to identify novel anti-inflammatory compounds. By providing mechanistic insights into the molecular basis of human-microbiome interactions, the project will generate essential new knowledge about causal relationships between the gut microbiome and the immune system in health and disease. By facilitating the elucidation of currently unknown microbiome-derived molecules, it will identify new genes, proteins, metabolites and host pathways for the development of future diagnostic and therapeutic applications.
Summary
The human gut microbiome is a complex ecosystem, which contributes essential functions to human physiology. Changes to the microbiome are associated with several chronic diseases characterised by inflammation, including neurodegenerative and autoimmune diseases. Microbiome-derived effector molecules comprising nucleic acids, (poly)peptides and metabolites are present at high levels in the gut but have so far eluded systematic study. This gap in knowledge is limiting mechanistic understanding of the microbiome’s functional impact on chronic diseases such as Parkinson’s disease (PD) and rheumatoid arthritis (RA). Here, I will for the first time integrate a combination of advanced high-resolution methodologies to comprehensively identify the constituents of this molecular complex and their impact on the human immune system. First, I will perform a quantitative, integrated multi-omic analysis on microbiome samples collected from healthy individuals and patients with newly diagnosed PD or RA. I will integrate and analyse the data using a newly developed knowledge base. Using contextualised prior knowledge (ExpoBiome Map) and machine learning methods, I will identify microbial molecules associated with condition-specific immunophenotypes. Second, I will validate and track the biomarker signature during a model clinical intervention (therapeutic fasting) to predict treatment outcomes. Third, microbes and molecules will be screened in personalised HuMiX gut-on-chip models to identify novel anti-inflammatory compounds. By providing mechanistic insights into the molecular basis of human-microbiome interactions, the project will generate essential new knowledge about causal relationships between the gut microbiome and the immune system in health and disease. By facilitating the elucidation of currently unknown microbiome-derived molecules, it will identify new genes, proteins, metabolites and host pathways for the development of future diagnostic and therapeutic applications.
Max ERC Funding
1 998 620 €
Duration
Start date: 2020-11-01, End date: 2025-10-31
Project acronym GEOFIN
Project Western banks in Eastern Europe: New geographies of financialisation
Researcher (PI) Martin Sokol
Host Institution (HI) THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Country Ireland
Call Details Consolidator Grant (CoG), SH3, ERC-2015-CoG
Summary Financialisation, or the growing power of finance over societies and economies, is increasingly recognised as the key feature of contemporary capitalism. However, significant gaps in our understanding of this process remain. Indeed, despite growing recognition that financialisation is an inherently spatial process, a geographically-informed view of financialisation remains underdeveloped. In addition, and related to this, the extent and the ways in which post-socialist ‘transition’ societies in East-Central Europe have been financialised remain under-researched and under-theorised. Yet, the examination of former state-socialist societies (built on the very opposite economic logic to that of financialisation) provides an unmatched opportunity to learn about financialisation itself, how it ‘penetrates’ societies and with what social and spatial implications. East-Central Europe in this sense constitutes a unique terrain for frontier research. GEOFIN will address the above shortcomings by producing empirical and theoretical insights to develop a geographically-informed view of financialisation. The objective is to examine how states, banks and households in post-socialist contexts have been financialised and to consider what implications this has for the societies in question and for Europe as a whole. The project will pilot a novel approach based on the concept of ‘financial chains’ which are understood both as channels of value transfer and as social relations that shape socio-economic processes and attendant economic geographies. A set of interlocking case studies will be mobilised to reveal the different ways in which banks, states and households across post-socialist East-Central Europe are interconnected by financial chains with each other and with a wider political economy. GEOFIN will fundamentally advance our understanding of new geographies of financialisation, opening up new horizons in studies of finance and its future role in the society.
Summary
Financialisation, or the growing power of finance over societies and economies, is increasingly recognised as the key feature of contemporary capitalism. However, significant gaps in our understanding of this process remain. Indeed, despite growing recognition that financialisation is an inherently spatial process, a geographically-informed view of financialisation remains underdeveloped. In addition, and related to this, the extent and the ways in which post-socialist ‘transition’ societies in East-Central Europe have been financialised remain under-researched and under-theorised. Yet, the examination of former state-socialist societies (built on the very opposite economic logic to that of financialisation) provides an unmatched opportunity to learn about financialisation itself, how it ‘penetrates’ societies and with what social and spatial implications. East-Central Europe in this sense constitutes a unique terrain for frontier research. GEOFIN will address the above shortcomings by producing empirical and theoretical insights to develop a geographically-informed view of financialisation. The objective is to examine how states, banks and households in post-socialist contexts have been financialised and to consider what implications this has for the societies in question and for Europe as a whole. The project will pilot a novel approach based on the concept of ‘financial chains’ which are understood both as channels of value transfer and as social relations that shape socio-economic processes and attendant economic geographies. A set of interlocking case studies will be mobilised to reveal the different ways in which banks, states and households across post-socialist East-Central Europe are interconnected by financial chains with each other and with a wider political economy. GEOFIN will fundamentally advance our understanding of new geographies of financialisation, opening up new horizons in studies of finance and its future role in the society.
Max ERC Funding
1 806 536 €
Duration
Start date: 2016-12-01, End date: 2022-05-31
Project acronym IndDecision
Project A neurally-informed behavioural modeling framework for examining individual and group difference in perceptual decision making
Researcher (PI) Redmond O'CONNELL
Host Institution (HI) THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Country Ireland
Call Details Consolidator Grant (CoG), SH4, ERC-2019-COG
Summary Pinpointing the mechanistic origins of inter-individual differences in decision making is a central goal of modern psychology and a considerable challenge because even elementary perceptual choices rely on a multitude of sensory, cognitive, motivational and motoric processes. For this reason, researchers have relied heavily on a set of mathematical ‘sequential sampling’ models that are designed to parse the latent psychological processes driving variations in choice behaviour. Although these models have been fruitfully employed in thousands of theoretical and neurophysiological investigations, they suffer from several limitations that particularly undermine their utility in inter-individual or -group comparisons including: A) parameter values are estimated on a relative, within-subject scale; B) the models come in many forms that can make identical behavioural predictions despite invoking fundamentally different mechanisms (‘model mimicry’); and C) they deal in abstract psychological constructs that are themselves dependent on multiple neural processes. The objective of this proposal is to address each of these issues by pioneering a ground-breaking decision modelling framework in which models are constructed and evaluated based on their ability to explain key observable aspects of the neural implementation of the human decision process in addition to its behavioural output. This ambitious goal is made possible by recent advances in non-invasive electrophysiology which enable direct observation, measurement and manipulation of the decision process as it unfolds in the human brain. Across a series of empirical investigations that will use adult aging as a test-bed for studying inter-individual and -group differences, this research will yield new methods for directly comparing model parameter values across subjects, resolve prominent theoretical debates regarding decision making algorithms and gain important new insights into their susceptibility to cognitive aging.
Summary
Pinpointing the mechanistic origins of inter-individual differences in decision making is a central goal of modern psychology and a considerable challenge because even elementary perceptual choices rely on a multitude of sensory, cognitive, motivational and motoric processes. For this reason, researchers have relied heavily on a set of mathematical ‘sequential sampling’ models that are designed to parse the latent psychological processes driving variations in choice behaviour. Although these models have been fruitfully employed in thousands of theoretical and neurophysiological investigations, they suffer from several limitations that particularly undermine their utility in inter-individual or -group comparisons including: A) parameter values are estimated on a relative, within-subject scale; B) the models come in many forms that can make identical behavioural predictions despite invoking fundamentally different mechanisms (‘model mimicry’); and C) they deal in abstract psychological constructs that are themselves dependent on multiple neural processes. The objective of this proposal is to address each of these issues by pioneering a ground-breaking decision modelling framework in which models are constructed and evaluated based on their ability to explain key observable aspects of the neural implementation of the human decision process in addition to its behavioural output. This ambitious goal is made possible by recent advances in non-invasive electrophysiology which enable direct observation, measurement and manipulation of the decision process as it unfolds in the human brain. Across a series of empirical investigations that will use adult aging as a test-bed for studying inter-individual and -group differences, this research will yield new methods for directly comparing model parameter values across subjects, resolve prominent theoretical debates regarding decision making algorithms and gain important new insights into their susceptibility to cognitive aging.
Max ERC Funding
1 996 310 €
Duration
Start date: 2021-01-01, End date: 2025-12-31
Project acronym MISFIRES
Project Misfires and Market Innovation: Toward a Collaborative Turn in Organising Markets
Researcher (PI) Susi Geiger
Host Institution (HI) UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Country Ireland
Call Details Consolidator Grant (CoG), SH3, ERC-2017-COG
Summary MISFIRES opens up new theoretical and empirical horizons for analysing and innovating ‘concerned markets’, where multiple actors’ interests, values and concerns clash. It asks how actors can engage with a market’s failures to challenge its organisation and make it more collaborative, more open to civic values and to social or political concerns. Concerned markets are contested by diverse actors with equally diverse perspectives and value measures. Evaluating such a market’s efficiency is as much of an illusion as redesigning its inner workings on a blackboard. We need new conceptual frameworks to understand how to innovate concerned markets from the inside to make them ‘better’ (as defined by concerned actors), and we urgently need empirical insights into how collaborative action in markets with such social and political stakes may translate into market change. MISFIRES relies on science and technology studies, pragmatic sociology and critical market studies to shift thinking around market organisation from failure and design to collaboration and experimentation. I devise an ethnographic and participatory inquiry to explore how a market’s failures can lead us to markets that are more attentive to and accommodating of the concerns they create. I choose three exemplary contested markets in healthcare (licensing of antiretroviral drugs, Hepatitis C pricing, and the sale of DNA information) and two emergent controversies to investigate the activities concerned actors undertake, and the instruments and devices they experiment with, to re-organise that market. MISFIRES will comprehensively map, engage in, and conceptualise this collaborative turn in organising markets. With this, MISFIRES will guide new academic and policy thinking by establishing how:
1) concerned actors voice and mobilise around the notion that a market has ‘failed’ them;
2) concerned actors seek to negotiate and address market failures;
3) this process may lead to ‘better’ markets.
Summary
MISFIRES opens up new theoretical and empirical horizons for analysing and innovating ‘concerned markets’, where multiple actors’ interests, values and concerns clash. It asks how actors can engage with a market’s failures to challenge its organisation and make it more collaborative, more open to civic values and to social or political concerns. Concerned markets are contested by diverse actors with equally diverse perspectives and value measures. Evaluating such a market’s efficiency is as much of an illusion as redesigning its inner workings on a blackboard. We need new conceptual frameworks to understand how to innovate concerned markets from the inside to make them ‘better’ (as defined by concerned actors), and we urgently need empirical insights into how collaborative action in markets with such social and political stakes may translate into market change. MISFIRES relies on science and technology studies, pragmatic sociology and critical market studies to shift thinking around market organisation from failure and design to collaboration and experimentation. I devise an ethnographic and participatory inquiry to explore how a market’s failures can lead us to markets that are more attentive to and accommodating of the concerns they create. I choose three exemplary contested markets in healthcare (licensing of antiretroviral drugs, Hepatitis C pricing, and the sale of DNA information) and two emergent controversies to investigate the activities concerned actors undertake, and the instruments and devices they experiment with, to re-organise that market. MISFIRES will comprehensively map, engage in, and conceptualise this collaborative turn in organising markets. With this, MISFIRES will guide new academic and policy thinking by establishing how:
1) concerned actors voice and mobilise around the notion that a market has ‘failed’ them;
2) concerned actors seek to negotiate and address market failures;
3) this process may lead to ‘better’ markets.
Max ERC Funding
1 923 780 €
Duration
Start date: 2018-08-01, End date: 2023-07-31
Project acronym SHARECITY
Project SHARECITY: Assessing the practice and sustainability potential of city-based food sharing economies
Researcher (PI) Anna Ray Davies
Host Institution (HI) THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Country Ireland
Call Details Consolidator Grant (CoG), SH3, ERC-2014-CoG
Summary With planetary urbanization fast approaching there is growing clarity regarding the unsustainability of cities, not least with respect to food consumption. Sharing, including food sharing, is increasingly being identified as one transformative mechanism for sustainable cities: reducing consumption; conserving resources, preventing waste and providing new forms of socio-economic relations. However, such claims currently rest on thin conceptual and empirical foundations. SHARECITY will identify and examine diverse practices of city-based food sharing economies, first determining their form, function and governance and then identifying their impact and potential to reorient eating practices. The research has four objectives: to advance theoretical understanding of contemporary food sharing economies in cities; to generate a significant body of comparative and novel international empirical knowledge about food sharing economies and their governance within global cities; to design and test an assessment framework for establishing the impact of city-based food sharing economies on societal relations, economic vitality and the environment; and to develop and implement a novel variant of backcasting to explore how food sharing economies within cities might evolve in the future. Providing conceptual insights that bridge sharing, social practice and urban transitions theories, SHARECITY will generate a typology of food sharing economies; a database of food sharing activities in 100 global cities; in-depth food sharing profiles of 7 cities from the contrasting contexts of USA, Brazil and Germany, Greece, Portugal, Ireland and Australia; a sustainability impact toolkit to enable examination of city-based food sharing initiatives; and scenarios for future food sharing in cities. Conducting such frontier science SHARECITY will open new research horizons to substantively improve understanding of how, why and to what end people share food within cities in the 21st Century.
Summary
With planetary urbanization fast approaching there is growing clarity regarding the unsustainability of cities, not least with respect to food consumption. Sharing, including food sharing, is increasingly being identified as one transformative mechanism for sustainable cities: reducing consumption; conserving resources, preventing waste and providing new forms of socio-economic relations. However, such claims currently rest on thin conceptual and empirical foundations. SHARECITY will identify and examine diverse practices of city-based food sharing economies, first determining their form, function and governance and then identifying their impact and potential to reorient eating practices. The research has four objectives: to advance theoretical understanding of contemporary food sharing economies in cities; to generate a significant body of comparative and novel international empirical knowledge about food sharing economies and their governance within global cities; to design and test an assessment framework for establishing the impact of city-based food sharing economies on societal relations, economic vitality and the environment; and to develop and implement a novel variant of backcasting to explore how food sharing economies within cities might evolve in the future. Providing conceptual insights that bridge sharing, social practice and urban transitions theories, SHARECITY will generate a typology of food sharing economies; a database of food sharing activities in 100 global cities; in-depth food sharing profiles of 7 cities from the contrasting contexts of USA, Brazil and Germany, Greece, Portugal, Ireland and Australia; a sustainability impact toolkit to enable examination of city-based food sharing initiatives; and scenarios for future food sharing in cities. Conducting such frontier science SHARECITY will open new research horizons to substantively improve understanding of how, why and to what end people share food within cities in the 21st Century.
Max ERC Funding
1 860 009 €
Duration
Start date: 2015-10-01, End date: 2021-07-31
