ERC FUNDED PROJECTS

The project will develop a new ethnography of statehood through architecture. It goes beyond conventional approaches to statehood, which describe states as an objectively existing set of tools used to run a country, and critical approaches that understand them as discursive constructs. Instead, this research understands statehood as a result of the relationship between functions and symbols, and will read it through an innovative new methodology, namely a study of state architecture. The study will focus on state buildings in Africa. African statehood, uncertain and often ambiguous, in many cases profoundly shaped by colonial heritages and post-colonial relationships, is reflected in classical-colonial, modernist-nationalist and post-modern or vernacular styles of architecture. African state buildings reveal the complex interplay of ideas, activities and relationships that together constitute an often uncomfortable statehood. They symbolise the state, embodying and projecting ideas of it through their aesthetics; they enable its concrete functions and processes; and they reveal what citizens think about the state in the ways they describe and negotiate them. The study is comparative, multi-layered and interdisciplinary. It focuses on seven countries (South Africa, Tanzania, DR Congo, Ethiopia, Ghana, Côte d’Ivoire and Guinea Bissau), exploring politics and statehood on domestic, regional and international levels, and drawing on theory and methods from political science, history, sociology, art and architecture theory. It employs innovative ethnographic methods, including the collection and display of photographs in interactive exhibitions staged in Africa to explore the ways citizens think about and use state buildings. This project will provide an innovative reading of how African statehood is expressed and how it looks and feels to African citizens. In doing this, it will make a distinctive new contribution to understanding how statehood works everywhere.

1 870 665 €

Start date: 2018-09-01, End date: 2023-08-31

Enzymes created by Nature are still more selective and can be orders of magnitude more efficient than man-made catalysts, in spite of recent advances in the design of de novo catalysts and in enzyme redesign. The optimal engineering of either small molecular or of complex biological catalysts requires both (i) accurate quantitative computational methods capable of a priori assessing catalytic efficiency, and (ii) molecular design principles and corresponding algorithms to achieve, understand and control biomolecular catalytic function and mechanisms. Presently, the computational design of biocatalysts is challenging due to the need for accurate yet computationally-intensive quantum mechanical calculations of bond formation and cleavage, as well as to the requirement for proper statistical sampling over very many degrees of freedom. Pioneering enhanced sampling and analysis methods have been developed to address crucial challenges bridging the gap between the available simulation length and the biologically relevant timescales. However, biased simulations do not generally permit the direct calculation of kinetic information. Recently, I and others pioneered simulation tools that can enable not only accurate calculations of free energies, but also of the intrinsic molecular kinetics and the underlying reaction mechanisms as well. I propose to develop more robust, automatic, and system-tailored sampling algorithms that are optimal in each case. I will use our kinetics-based methods to develop a novel theoretical framework to address catalytic efficiency and to establish molecular design principles to key design problems for new bio-inspired nanocatalysts, and to identify and characterize small molecule modulators of enzyme activity. This is a highly interdisciplinary project that will enable fundamental advances in molecular simulations and will unveil the physical principles that will lead to design and control of catalysis with Nature-like efficiency.

1 499 999 €

Start date: 2018-02-01, End date: 2023-01-31

Manuscripts which contain commentary alongside the biblical text are some of the most significant and complicated witnesses to the Greek New Testament. First compiled around the fifth century, the commentaries consist of chains of extracts from earlier writers (catenae). These manuscripts became the main way in which users encountered both the text and the interpretation of the New Testament; revised editions produced in the eleventh and twelfth centuries continued to hold the field until the invention of printing. Recent advances have shown that commentary manuscripts play a much more important role than previously thought in the history of the New Testament. The number of known copies has increased by 20% following a preliminary survey last year which identified 100 additional manuscripts. A recent comprehensive textual analysis of the Catholic Epistles indicated that all witnesses from the third generation onwards (some 72% of the total) could stem from the biblical text of three commentary manuscripts occupying a key place in the textual tradition. Investigation of the catena on Mark has shown that the selection of extracts could offer a new approach to understanding the theology of the compilers and the transmission of the commentaries. The CATENA Project will use digital tools to undertake a fuller examination of Greek New Testament commentary manuscripts than has ever before been possible. This will include an exhaustive survey to establish a complete list of witnesses; a database of extracts to examine their principles of organisation and relationships; and electronic transcriptions to determine their role in the transmission of the biblical text. The results will have a direct impact on editions of the Greek New Testament, providing a new understanding of its text and reception and leading to broader insights into history and culture.

1 756 928 €

Start date: 2018-06-01, End date: 2023-05-31

Visual perception is central to how we think and behave. However, there are major unresolved issues in understanding how the human mind draws on experience to perceive the dynamic and variable world. The COLOURMIND project, led by Franklin, will tackle these crucial issues with an ambitious investigation of the impact of the visual environment on colour perception that will provide a new theoretical framework for the field. The project will ask ground-breaking questions: What aspects of colour perception are affected by the visual environment, such that people from different environments perceive colour differently?; What processes enable colour perception to calibrate to visual experience and what is their nature and scope?; Does colour perception ‘tune-in’ to the visual input experienced during infancy? COLOURMIND will adopt a diverse range of innovative methods to address these questions, and will: i.) investigate the colour perception of people immersed in natural non-industrialised environments in some of the remotest parts of the world to identify the extent to which visual environment shapes colour perception; ii.) use innovative neuroimaging methods to identify how the visual cortex changes in response to chromatic experience; iii.) pioneer the use of ‘Altered-Reality' (next generation virtual reality) to elucidate calibrative processes in colour perception; and iv.) conduct carefully controlled experiments with infants to address the role of development. The cutting-edge questions, innovative approaches and theoretical power of the COLOURMIND project will lead to breakthroughs on issues that are fundamental to understanding the complexity of the human mind (e.g., learning, plasticity and inference; perceptual development; cultural relativity), and findings will have practical application. Overall, the ambitious project will push the frontiers of multidisciplinary research on colour perception, and will resonate throughout the cognitive and social sciences.

1 999 975 €

Start date: 2018-07-01, End date: 2023-06-30