Project acronym CASSPIN
Project Comparative Analysis of Social Spaces in Post-Industrial Nations
Researcher (PI) William James Atkinson
Host Institution (HI) UNIVERSITY OF BRISTOL
Call Details Starting Grant (StG), SH2, ERC-2015-STG
Summary The proposed research has two overarching objectives. First, it aims to examine whether it is possible and appropriate to extend a novel way of measuring social class recently devised for the United Kingdom to other post-industrial nations for the purposes of cross-national comparative research. If it is, the project will begin to explore, through secondary and primary analysis of large-scale survey data, the different shapes and trajectories of the class structures – or ‘social spaces’ – of various nation states. This will involve examination of which classes and sub-classes predominate and which have emerged or declined, as well as the different gender and ethnic/nationality constitutions of the classes and the distinct effects these differences have for understanding cultural and political struggles and, ultimately, the distribution of power or ‘recognition’ in each country. Second, the project aims to explore, through both statistical analysis and qualitative interviews, how social class is actually lived, experienced and balanced against other pressures and sources of recognition in everyday life, with a focus on three specific nations: the United States, Germany and Sweden. Of particular interest in this respect is the balancing of desire for recognition through money and education – the two cornerstones of social class in post-industrial capitalist societies – and their associated lifestyles with desires for recognition and love within the family. The comparative analysis included in both research aims will be guided by the hypothesis that national differences depend on the nature of the welfare regime in operation, especially as it relates to the nature and extent of workforce feminisation, though the research will also be alive to the possibility of alternative – or no significant – sources of contrast.
Summary
The proposed research has two overarching objectives. First, it aims to examine whether it is possible and appropriate to extend a novel way of measuring social class recently devised for the United Kingdom to other post-industrial nations for the purposes of cross-national comparative research. If it is, the project will begin to explore, through secondary and primary analysis of large-scale survey data, the different shapes and trajectories of the class structures – or ‘social spaces’ – of various nation states. This will involve examination of which classes and sub-classes predominate and which have emerged or declined, as well as the different gender and ethnic/nationality constitutions of the classes and the distinct effects these differences have for understanding cultural and political struggles and, ultimately, the distribution of power or ‘recognition’ in each country. Second, the project aims to explore, through both statistical analysis and qualitative interviews, how social class is actually lived, experienced and balanced against other pressures and sources of recognition in everyday life, with a focus on three specific nations: the United States, Germany and Sweden. Of particular interest in this respect is the balancing of desire for recognition through money and education – the two cornerstones of social class in post-industrial capitalist societies – and their associated lifestyles with desires for recognition and love within the family. The comparative analysis included in both research aims will be guided by the hypothesis that national differences depend on the nature of the welfare regime in operation, especially as it relates to the nature and extent of workforce feminisation, though the research will also be alive to the possibility of alternative – or no significant – sources of contrast.
Max ERC Funding
1 467 038 €
Duration
Start date: 2016-05-01, End date: 2021-04-30
Project acronym CLD
Project China, Law, and Development
Researcher (PI) Matthew ERIE
Host Institution (HI) THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Call Details Starting Grant (StG), SH2, ERC-2018-STG
Summary The world is in the midst of a sea change in approaches to development. The rise of nationalist politics in the U.S., U.K. and Europe have questioned commitments to global governance at the same time that China has emerged as a champion of globalization, a turn of geo-political events that would have been unfathomable ten years ago. Through its own multi-lateral institutions, China is setting a new agenda for development from Europe to Oceania. China’s approach differs from Anglo/Euro/American approaches to “law and development” (LD). Whereas LD orthodoxy has sought to improve legal institutions in poor states, Chinese do not foster rule of law abroad. Instead, Chinese view law as one set of rules, among others, to facilitate economic transactions and not to foster democratization. This distinction has sparked a global debate about the so-called “China model” as an alternative to LD. Yet there is little empirical data with which to assess the means and ends of China’s expanded footprint, a question with long-term implications for much of the developing world. This project addresses that problem by proposing that even if Chinese cross-border development does not operate through transparent rules, it nonetheless has its own notion of order. The project adopts a multi-sited, mixed method, and interdisciplinary approach—at the intersection of comparative law, developmental studies, and legal anthropology—to understand the nature of China’s order. The project has two objectives:
1. To establish the conceptual bases for the study of China’s approach to law and development by developing the first systematic study of the impacts of Chinese investment on the legal systems of developing economies.
2. To experiment with a comparative research design to theorize how China’s approach suggests a type of order that extends through a conjuncture of regional and local processes and manifests itself differently in diverse contexts.
Summary
The world is in the midst of a sea change in approaches to development. The rise of nationalist politics in the U.S., U.K. and Europe have questioned commitments to global governance at the same time that China has emerged as a champion of globalization, a turn of geo-political events that would have been unfathomable ten years ago. Through its own multi-lateral institutions, China is setting a new agenda for development from Europe to Oceania. China’s approach differs from Anglo/Euro/American approaches to “law and development” (LD). Whereas LD orthodoxy has sought to improve legal institutions in poor states, Chinese do not foster rule of law abroad. Instead, Chinese view law as one set of rules, among others, to facilitate economic transactions and not to foster democratization. This distinction has sparked a global debate about the so-called “China model” as an alternative to LD. Yet there is little empirical data with which to assess the means and ends of China’s expanded footprint, a question with long-term implications for much of the developing world. This project addresses that problem by proposing that even if Chinese cross-border development does not operate through transparent rules, it nonetheless has its own notion of order. The project adopts a multi-sited, mixed method, and interdisciplinary approach—at the intersection of comparative law, developmental studies, and legal anthropology—to understand the nature of China’s order. The project has two objectives:
1. To establish the conceptual bases for the study of China’s approach to law and development by developing the first systematic study of the impacts of Chinese investment on the legal systems of developing economies.
2. To experiment with a comparative research design to theorize how China’s approach suggests a type of order that extends through a conjuncture of regional and local processes and manifests itself differently in diverse contexts.
Max ERC Funding
1 499 381 €
Duration
Start date: 2019-01-01, End date: 2023-12-31
Project acronym EXPOVIBE
Project Exposure to Political Violence and Individual Behavior
Researcher (PI) Arzu Kibris
Host Institution (HI) THE UNIVERSITY OF WARWICK
Call Details Starting Grant (StG), SH2, ERC-2015-STG
Summary This project will explore how exposure to political violence in a civil conflict context impacts upon social, economic and political behavior of individuals. It has three legs. In the first leg I will analyze the association between political and domestic violence. Specifically, I will test the hypothesis that those exposed to political violence are more likely to be perpetrators of domestic violence. In the second leg I will analyze whether exposure to political violence impacts upon economic behavior. Specifically, I will analyze the impact of exposure on risk, time and social preferences, savings behavior, employment, and earnings. Finally, in the third leg I will look into political behavior. Specifically, I will analyze the association between exposure to political violence and political participation and support, political tolerance, ideology, voting behavior, and party choice. The project will make use of a natural experiment setting that the institutional setup and the long-running civil conflict in Turkey create. Turkey has a mandatory military service system that requires each Turkish man, when he comes to age, to serve in the army for about a year. Those drafted are first subject to a basic training program and then, via a lottery, are randomly assigned to military bases all over the country to serve the rest of their terms. This means a young soldier can be sent to a military base in Eastern or Southeastern Turkey where a bloody armed conflict between the Turkish armed forces and the insurgent organization PKK has been going on since August 1984, and thus, can get actively involved in the armed conflict. This is a natural experiment setting that randomly exposes young Turkish males to political violence. In this project I aim to study whether and how that exposure impacts upon social, economic and political behavior of the exposed. To accomplish these goals, two independent, large-n survey studies will be designed and conducted in Turkey.
Summary
This project will explore how exposure to political violence in a civil conflict context impacts upon social, economic and political behavior of individuals. It has three legs. In the first leg I will analyze the association between political and domestic violence. Specifically, I will test the hypothesis that those exposed to political violence are more likely to be perpetrators of domestic violence. In the second leg I will analyze whether exposure to political violence impacts upon economic behavior. Specifically, I will analyze the impact of exposure on risk, time and social preferences, savings behavior, employment, and earnings. Finally, in the third leg I will look into political behavior. Specifically, I will analyze the association between exposure to political violence and political participation and support, political tolerance, ideology, voting behavior, and party choice. The project will make use of a natural experiment setting that the institutional setup and the long-running civil conflict in Turkey create. Turkey has a mandatory military service system that requires each Turkish man, when he comes to age, to serve in the army for about a year. Those drafted are first subject to a basic training program and then, via a lottery, are randomly assigned to military bases all over the country to serve the rest of their terms. This means a young soldier can be sent to a military base in Eastern or Southeastern Turkey where a bloody armed conflict between the Turkish armed forces and the insurgent organization PKK has been going on since August 1984, and thus, can get actively involved in the armed conflict. This is a natural experiment setting that randomly exposes young Turkish males to political violence. In this project I aim to study whether and how that exposure impacts upon social, economic and political behavior of the exposed. To accomplish these goals, two independent, large-n survey studies will be designed and conducted in Turkey.
Max ERC Funding
938 184 €
Duration
Start date: 2017-04-01, End date: 2022-03-31
Project acronym FIDELIO
Project Forecasting social Impacts of bioDiversity consErvation poLicies In EurOpe
Researcher (PI) Nikoleta JONES
Host Institution (HI) ANGLIA RUSKIN UNIVERSITY HIGHER EDUCATION CORPORATION
Call Details Starting Grant (StG), SH2, ERC-2018-STG
Summary Designating Protected Areas (PAs) is the most important policy tool for biodiversity conservation. Over 100 new PAs have been established in the past 36 months in European Union territory. However, effective management of PAs is often obstructed by conflicts mainly associated with the social impacts (SIs) imposed on local communities by their establishment. Despite the importance of these SIs there are certain aspects in this field that remain significantly under-researched. There is now an increasing need to incorporate SI assessments in decision making processes by providing a clear framework explaining how perceptions of these impacts are created and predicting their change in the future. This will support the achievement of international goals for biodiversity conservation and adaptation to climate change as well as better accounting for social justice issues for communities dependent on protected natural resources. The aim of FIDELIO is to develop for the first time a new paradigm in order to understand how perceptions of SIs are formulated taking into consideration the dimensions of space and time. FIDELIO will assist in increasing public engagement and the incorporation of local opinions in decision-making. It will also facilitate the process of policy development and a reduction in conflicts between different stakeholders in PAs. FIDELIO will last 5 years and its research objectives will be explored through the application of a mixed-methods approach including the implementation of two rounds of social surveys in 4 PAs across Europe and the testing of the framework in 15 additional PAs. This is an extremely timely project considering the steady increase of new PAs and the re-designation of current ones. FIDELIO will contribute to the better understanding of SIs and facilitate predictions for their change in the future, while assisting in maximizing social benefits for local communities arising from the designation of a PA.
Summary
Designating Protected Areas (PAs) is the most important policy tool for biodiversity conservation. Over 100 new PAs have been established in the past 36 months in European Union territory. However, effective management of PAs is often obstructed by conflicts mainly associated with the social impacts (SIs) imposed on local communities by their establishment. Despite the importance of these SIs there are certain aspects in this field that remain significantly under-researched. There is now an increasing need to incorporate SI assessments in decision making processes by providing a clear framework explaining how perceptions of these impacts are created and predicting their change in the future. This will support the achievement of international goals for biodiversity conservation and adaptation to climate change as well as better accounting for social justice issues for communities dependent on protected natural resources. The aim of FIDELIO is to develop for the first time a new paradigm in order to understand how perceptions of SIs are formulated taking into consideration the dimensions of space and time. FIDELIO will assist in increasing public engagement and the incorporation of local opinions in decision-making. It will also facilitate the process of policy development and a reduction in conflicts between different stakeholders in PAs. FIDELIO will last 5 years and its research objectives will be explored through the application of a mixed-methods approach including the implementation of two rounds of social surveys in 4 PAs across Europe and the testing of the framework in 15 additional PAs. This is an extremely timely project considering the steady increase of new PAs and the re-designation of current ones. FIDELIO will contribute to the better understanding of SIs and facilitate predictions for their change in the future, while assisting in maximizing social benefits for local communities arising from the designation of a PA.
Max ERC Funding
1 495 786 €
Duration
Start date: 2019-02-01, End date: 2024-01-31
Project acronym HRNUDGE
Project A NUDGE IN THE RIGHTS DIRECTION? REDESIGNING THE ARCHITECTURE OF HUMAN RIGHTS REMEDIES
Researcher (PI) Veronika FIKFAK
Host Institution (HI) THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Call Details Starting Grant (StG), SH2, ERC-2018-STG
Summary Recent years have seen a renewed interest in the effectiveness of human rights law and judgments, yet almost no attention has been given to the impact of remedies on states’ compliance practices or the internalisation of human rights into their domestic legal systems. Through a combination of quantitative and qualitative research in six countries, the project aims to expose the dynamics of the (non)compliant state and the efficacy of different types of remedies in changing the behaviour of human rights violators. These goals will be achieved through three sub-studies: (1) an empirical study of the case law of the European Court of Human Rights (ECtHR) to determine the compliance and internalisation practices and their link to different remedies; (2) the exploration and analysis of states’ internalisation practices and policies (including the identification of players that shape this practice) to determine whether remedies play a crucial role in shifting states’ actions; (3) a computer simulation to discover how we can change the architecture of human rights remedies to increase compliance and internalisation, and to deter future violations.
The central aim of the project is to identify new remedy options – incentives or nudges – which human rights institutions can use to deter future violations. Using the example of the ECtHR and its caselaw, the research will build on insights from behavioural economics to interrogate widespread assumptions about monetisation of human rights, public shaming, and deference shown to states in the specification of remedies. Through computer simulation, the project will aim to predict how monetary and non-monetary remedies could be used separately or together to alter the behaviour of states and their key players. The research will be ground-breaking in many ways, reshaping the field of human rights remedies and contributing crucially to the emerging field of behavioural international law.
Summary
Recent years have seen a renewed interest in the effectiveness of human rights law and judgments, yet almost no attention has been given to the impact of remedies on states’ compliance practices or the internalisation of human rights into their domestic legal systems. Through a combination of quantitative and qualitative research in six countries, the project aims to expose the dynamics of the (non)compliant state and the efficacy of different types of remedies in changing the behaviour of human rights violators. These goals will be achieved through three sub-studies: (1) an empirical study of the case law of the European Court of Human Rights (ECtHR) to determine the compliance and internalisation practices and their link to different remedies; (2) the exploration and analysis of states’ internalisation practices and policies (including the identification of players that shape this practice) to determine whether remedies play a crucial role in shifting states’ actions; (3) a computer simulation to discover how we can change the architecture of human rights remedies to increase compliance and internalisation, and to deter future violations.
The central aim of the project is to identify new remedy options – incentives or nudges – which human rights institutions can use to deter future violations. Using the example of the ECtHR and its caselaw, the research will build on insights from behavioural economics to interrogate widespread assumptions about monetisation of human rights, public shaming, and deference shown to states in the specification of remedies. Through computer simulation, the project will aim to predict how monetary and non-monetary remedies could be used separately or together to alter the behaviour of states and their key players. The research will be ground-breaking in many ways, reshaping the field of human rights remedies and contributing crucially to the emerging field of behavioural international law.
Max ERC Funding
1 493 976 €
Duration
Start date: 2019-03-01, End date: 2024-02-29
Project acronym IMAGINE
Project Geographical imaginations and the (geo)politics of volcanic risk: cultures, knowledges, actions
Researcher (PI) Amy DONOVAN
Host Institution (HI) THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Call Details Starting Grant (StG), SH2, ERC-2018-STG
Summary Volcanoes can be cultural symbols, a source of fear, of fascination and of scientific study and a practical problem for civil protection: they involve complex social, cultural and political dynamics, and often have multi-scalar, trans-border impacts. Yet the management of volcanic risk tends to be strongly dependent on uncertain information from physical scientists about volcanic activity, with social scientific studies concentrating on social vulnerability and communication, and there is a relative dearth of studies that address the cultural and (geo)political contexts of scientific knowledge production in particular places. Geographers have explored the role of “geographical imaginations” in scientific discourses in other fields such as climate change: people, including scientists, imagine the social and physical landscapes around them. This project seeks to combine science studies, human geography and disaster risk reduction to provide a holistic approach to volcanic risk, and inform ongoing discussions about scientific advice in disasters more broadly, through a consideration of the geographical imaginations of scientists and populations. It focuses on understanding volcanic and disaster risk as a consequence of complex interactions and relationships between landscape, community, science and politics that blur the boundaries between society and nature. It combines methods from the social and physical sciences in Latin America and East Africa to investigate: (i) the ways in which scientists and people who live on volcanoes interpret and live with their environment; (ii) the interaction of national authorities with these modes of living, and how national borders affect them; (iii) the power dynamics of warnings within these contexts and across them; (iv) the implications of this approach for disaster risk reduction more broadly. Outcomes will include two books, several sets of scientific papers and three international meetings.
Summary
Volcanoes can be cultural symbols, a source of fear, of fascination and of scientific study and a practical problem for civil protection: they involve complex social, cultural and political dynamics, and often have multi-scalar, trans-border impacts. Yet the management of volcanic risk tends to be strongly dependent on uncertain information from physical scientists about volcanic activity, with social scientific studies concentrating on social vulnerability and communication, and there is a relative dearth of studies that address the cultural and (geo)political contexts of scientific knowledge production in particular places. Geographers have explored the role of “geographical imaginations” in scientific discourses in other fields such as climate change: people, including scientists, imagine the social and physical landscapes around them. This project seeks to combine science studies, human geography and disaster risk reduction to provide a holistic approach to volcanic risk, and inform ongoing discussions about scientific advice in disasters more broadly, through a consideration of the geographical imaginations of scientists and populations. It focuses on understanding volcanic and disaster risk as a consequence of complex interactions and relationships between landscape, community, science and politics that blur the boundaries between society and nature. It combines methods from the social and physical sciences in Latin America and East Africa to investigate: (i) the ways in which scientists and people who live on volcanoes interpret and live with their environment; (ii) the interaction of national authorities with these modes of living, and how national borders affect them; (iii) the power dynamics of warnings within these contexts and across them; (iv) the implications of this approach for disaster risk reduction more broadly. Outcomes will include two books, several sets of scientific papers and three international meetings.
Max ERC Funding
1 437 933 €
Duration
Start date: 2019-07-01, End date: 2024-06-30
Project acronym LINKS
Project Kick-starting global cLimate Investments:uncovering hidden liNks in climate finance and exploring dynamic evolution of investment networKs for policy deSign
Researcher (PI) Nadia AMELI
Host Institution (HI) UNIVERSITY COLLEGE LONDON
Call Details Starting Grant (StG), SH2, ERC-2018-STG
Summary LINKS aims to contribute to a transformation of the climate finance system to deliver the scale and quality of investment needed to meet the Paris climate goals and ensure effective capital allocation. By understanding the architecture of the financial system, exploring macro patterns in low-carbon investment emerging from observed investors’ behaviour and interactions, and designing cross-cutting policies aligned with long-term climate targets, LINKS will promote essential guidance for a re-orientation of financial flows towards low-carbon and energy efficiency investments.
LINKS aims to advance the understanding of the role of climate finance to foster the low-carbon transition by using network theory, advanced computational techniques and extensive empirical data to model the financial system as a complex adaptive system. LINKS will thus lay the foundations of, and pioneer a new field, namely climate finance networks, where dynamics of interconnected investors represented as a network, results in the complex behavior of the whole system.
LINKS will bring together interdisciplinary theories and developments in finance, environmental economics, sociology, computer science, network analysis and complexity in an integrated approach to study and model climate finance. Taking this approach will allow advancements in at least three directions: i) a new theoretical approach to account for complexity thinking and systemic perspective in climate finance, ii) more empirical analyses on networks structures of low-carbon investments and their dynamics to shape the development of the climate finance system, iii) policy modelling analyses to explore whether specific architectures of the climate finance system have significant impact on the effectiveness of climate public policies and invested public resources. LINKS will thus deliver robust conclusions on how the financial system could contribute to the required investments to achieve the low-carbon transition.
Summary
LINKS aims to contribute to a transformation of the climate finance system to deliver the scale and quality of investment needed to meet the Paris climate goals and ensure effective capital allocation. By understanding the architecture of the financial system, exploring macro patterns in low-carbon investment emerging from observed investors’ behaviour and interactions, and designing cross-cutting policies aligned with long-term climate targets, LINKS will promote essential guidance for a re-orientation of financial flows towards low-carbon and energy efficiency investments.
LINKS aims to advance the understanding of the role of climate finance to foster the low-carbon transition by using network theory, advanced computational techniques and extensive empirical data to model the financial system as a complex adaptive system. LINKS will thus lay the foundations of, and pioneer a new field, namely climate finance networks, where dynamics of interconnected investors represented as a network, results in the complex behavior of the whole system.
LINKS will bring together interdisciplinary theories and developments in finance, environmental economics, sociology, computer science, network analysis and complexity in an integrated approach to study and model climate finance. Taking this approach will allow advancements in at least three directions: i) a new theoretical approach to account for complexity thinking and systemic perspective in climate finance, ii) more empirical analyses on networks structures of low-carbon investments and their dynamics to shape the development of the climate finance system, iii) policy modelling analyses to explore whether specific architectures of the climate finance system have significant impact on the effectiveness of climate public policies and invested public resources. LINKS will thus deliver robust conclusions on how the financial system could contribute to the required investments to achieve the low-carbon transition.
Max ERC Funding
1 499 956 €
Duration
Start date: 2019-09-01, End date: 2024-08-31
Project acronym LO-ACT
Project Low Carbon Action in Ordinary Cities
Researcher (PI) Vanesa CASTAN BROTO
Host Institution (HI) THE UNIVERSITY OF SHEFFIELD
Call Details Starting Grant (StG), SH2, ERC-2018-STG
Summary The challenge of LO-ACT is to enable low carbon urban development in medium and small cities in rapidly urbanising areas in East, Central and West Africa, South Asia and South East Asia. The majority of emissions in the next century will be emitted by infrastructures that are yet to be built, particularly in rapidly urbanising areas where infrastructure is lacking. Population forecasts suggest that most population growth will take place in small and medium cities. Yet, to date, research on climate action has focused on showcasing strongly branded, successful initiatives in global cities. The low carbon transition depends on myriad of actions in ordinary cities, that is, cities outside global networks of climate innovation and leadership. LO-ACT will address this critical gap by delivering the first multi-dimensional, large scale assessment of low carbon action in ordinary cities. It will contribute a new framework to understand global environmental politics and urban governance.
First, LO-ACT will analyse the imaginaries of local action that have shaped global environmental politics over 30 years (Objective 1). The work programme will also analyse the mobility of low carbon urban policies in transport, energy, and housing across different urban contexts (Objective 2). LO-ACT will deliver a comparative analysis of urban trajectories in 113 ordinary cities, and five in-depth ethnographic case studies (Objective 3). Finally, it will provide a critical assessment of governance theory and a revised framework to acknowledge the messy and ordinary contexts of urban action (Objective 4).
LO-ACT will bring together an interdisciplinary, international team of researchers, an international network of academic advisors, and four regional hubs that will support context-specific data collection and analysis. The research will contribute to the fields of human geography, urban studies, environmental politics, sustainability transitions and science and technology studies.
Summary
The challenge of LO-ACT is to enable low carbon urban development in medium and small cities in rapidly urbanising areas in East, Central and West Africa, South Asia and South East Asia. The majority of emissions in the next century will be emitted by infrastructures that are yet to be built, particularly in rapidly urbanising areas where infrastructure is lacking. Population forecasts suggest that most population growth will take place in small and medium cities. Yet, to date, research on climate action has focused on showcasing strongly branded, successful initiatives in global cities. The low carbon transition depends on myriad of actions in ordinary cities, that is, cities outside global networks of climate innovation and leadership. LO-ACT will address this critical gap by delivering the first multi-dimensional, large scale assessment of low carbon action in ordinary cities. It will contribute a new framework to understand global environmental politics and urban governance.
First, LO-ACT will analyse the imaginaries of local action that have shaped global environmental politics over 30 years (Objective 1). The work programme will also analyse the mobility of low carbon urban policies in transport, energy, and housing across different urban contexts (Objective 2). LO-ACT will deliver a comparative analysis of urban trajectories in 113 ordinary cities, and five in-depth ethnographic case studies (Objective 3). Finally, it will provide a critical assessment of governance theory and a revised framework to acknowledge the messy and ordinary contexts of urban action (Objective 4).
LO-ACT will bring together an interdisciplinary, international team of researchers, an international network of academic advisors, and four regional hubs that will support context-specific data collection and analysis. The research will contribute to the fields of human geography, urban studies, environmental politics, sustainability transitions and science and technology studies.
Max ERC Funding
1 393 979 €
Duration
Start date: 2019-02-01, End date: 2024-01-31
Project acronym Mito-recombine
Project Homologous recombination and its application in manipulating animal mitochondrial DNA
Researcher (PI) Hansong MA
Host Institution (HI) THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Call Details Starting Grant (StG), LS2, ERC-2018-STG
Summary Mitochondrial DNA (mtDNA) is a multi-copy genome that works with the nuclear genome to control energy production and various cellular processes. To date, disorders associated with mutations in mtDNA are among the most common genetically inherited metabolic diseases1. However, our knowledge regarding many aspects of mtDNA biology remains limited, and we know even less about how it influences development and organismal traits. This is largely due to our inability to manipulate mtDNA. Recently, a colleague and I developed novel genetic tools in Drosophila that allowed us to isolate animal mitochondrial mutants for the first time, and to create heteroplasmic organisms containing two mitochondrial genotypes2,3. These advances make Drosophila a powerful system for mtDNA studies. Importantly, I showed that Drosophila mtDNA could undergo homologous recombination. Furthermore, I established a system to induce recombination at specific sites and select for progeny containing only the recombinant genome4. Thus, my work has demonstrated the existence of recombination in animal mitochondria, and opens up the possibility of developing a recombination system for functional mapping and manipulating animal mtDNA. Here I propose to 1) identify components of the mitochondrial recombination machinery by a candidate RNAi screen; 2) develop a recombination toolkit to map trait-associated mtDNA sequences/SNPs; and 3) build a site-directed mutagenesis system by establishing robust ways to deliver DNA into fly mitochondria. Given the essential functions of mitochondria and their involvement in incurable diseases, the genetic tools developed in this proposal will transform the field by making it possible to link mtDNA variations to phenotypic differences and introduce specific mutations into mtDNA for functional studies at organismal level. These advances will open many possibilities to accelerate our understanding on how mtDNA impacts health, disease and evolution.
Summary
Mitochondrial DNA (mtDNA) is a multi-copy genome that works with the nuclear genome to control energy production and various cellular processes. To date, disorders associated with mutations in mtDNA are among the most common genetically inherited metabolic diseases1. However, our knowledge regarding many aspects of mtDNA biology remains limited, and we know even less about how it influences development and organismal traits. This is largely due to our inability to manipulate mtDNA. Recently, a colleague and I developed novel genetic tools in Drosophila that allowed us to isolate animal mitochondrial mutants for the first time, and to create heteroplasmic organisms containing two mitochondrial genotypes2,3. These advances make Drosophila a powerful system for mtDNA studies. Importantly, I showed that Drosophila mtDNA could undergo homologous recombination. Furthermore, I established a system to induce recombination at specific sites and select for progeny containing only the recombinant genome4. Thus, my work has demonstrated the existence of recombination in animal mitochondria, and opens up the possibility of developing a recombination system for functional mapping and manipulating animal mtDNA. Here I propose to 1) identify components of the mitochondrial recombination machinery by a candidate RNAi screen; 2) develop a recombination toolkit to map trait-associated mtDNA sequences/SNPs; and 3) build a site-directed mutagenesis system by establishing robust ways to deliver DNA into fly mitochondria. Given the essential functions of mitochondria and their involvement in incurable diseases, the genetic tools developed in this proposal will transform the field by making it possible to link mtDNA variations to phenotypic differences and introduce specific mutations into mtDNA for functional studies at organismal level. These advances will open many possibilities to accelerate our understanding on how mtDNA impacts health, disease and evolution.
Max ERC Funding
1 473 732 €
Duration
Start date: 2019-03-01, End date: 2024-02-29
Project acronym SexMeth
Project Establishment, modulation and inheritance of sexual lineage specific DNA methylation in plants
Researcher (PI) Xiaoqi FENG
Host Institution (HI) JOHN INNES CENTRE
Call Details Starting Grant (StG), LS2, ERC-2018-STG
Summary DNA methylation is an epigenetic mechanism carrying regulatory information across generations in plants and animals. Germlines – called sexual lineages (SLs) in plants – are essential for understanding methylation-based epigenetics because they mediate inheritance and undergo large-scale methylation reprogramming. Germline methylation reprogramming is also crucial for reproduction. However, our understanding of plant SL epigenetics is in its infancy.
I have done some of the first and most influential work in plant SL epigenetics, and developed advanced techniques for the isolation and epigenomic analysis of rare plant cell types. Recently my lab discovered that the small RNA-directed DNA methylation pathway, which generally only targets transposons, induces methylation of genes specifically in SLs, thereby regulating gene expression and meiosis. Our results also indicate that genic methylation is established in meiocytes (the origin of the male SL) by soma-derived small RNAs that are attenuated by heat stress, suggesting the hypothesis that environmentally malleable heritable information flows from soma to the germline.
We will test our hypothesis and reveal the molecular mechanisms underlying SL-specific DNA methylation in plants by pursuing the following objectives:
1. Determine how SL-specific genic methylation is established in meiocytes
2. Reveal how sRNA biogenesis and transport mediate DNA methylation in the male SL
3. Elucidate environmental modulation and transgenerational inheritance of SL methylation
Our research will reveal how new genomic loci become methylated and stay methylated through cell divisions, and how methylation is adjusted by the environment and carried to the next generation to influence phenotype. This knowledge will revolutionize our understanding of developmentally regulated methylation reprogramming, and will be invaluable for site- and/or cell type- specific engineering of DNA methylation.
Summary
DNA methylation is an epigenetic mechanism carrying regulatory information across generations in plants and animals. Germlines – called sexual lineages (SLs) in plants – are essential for understanding methylation-based epigenetics because they mediate inheritance and undergo large-scale methylation reprogramming. Germline methylation reprogramming is also crucial for reproduction. However, our understanding of plant SL epigenetics is in its infancy.
I have done some of the first and most influential work in plant SL epigenetics, and developed advanced techniques for the isolation and epigenomic analysis of rare plant cell types. Recently my lab discovered that the small RNA-directed DNA methylation pathway, which generally only targets transposons, induces methylation of genes specifically in SLs, thereby regulating gene expression and meiosis. Our results also indicate that genic methylation is established in meiocytes (the origin of the male SL) by soma-derived small RNAs that are attenuated by heat stress, suggesting the hypothesis that environmentally malleable heritable information flows from soma to the germline.
We will test our hypothesis and reveal the molecular mechanisms underlying SL-specific DNA methylation in plants by pursuing the following objectives:
1. Determine how SL-specific genic methylation is established in meiocytes
2. Reveal how sRNA biogenesis and transport mediate DNA methylation in the male SL
3. Elucidate environmental modulation and transgenerational inheritance of SL methylation
Our research will reveal how new genomic loci become methylated and stay methylated through cell divisions, and how methylation is adjusted by the environment and carried to the next generation to influence phenotype. This knowledge will revolutionize our understanding of developmentally regulated methylation reprogramming, and will be invaluable for site- and/or cell type- specific engineering of DNA methylation.
Max ERC Funding
1 499 998 €
Duration
Start date: 2018-09-01, End date: 2023-08-31