Project acronym 3D-E
Project 3D Engineered Environments for Regenerative Medicine
Researcher (PI) Ruth Elizabeth Cameron
Host Institution (HI) THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Call Details Advanced Grant (AdG), PE8, ERC-2012-ADG_20120216
Summary "This proposal develops a unified, underpinning technology to create novel, complex and biomimetic 3D environments for the control of tissue growth. As director of Cambridge Centre for Medical Materials, I have recently been approached by medical colleagues to help to solve important problems in the separate therapeutic areas of breast cancer, cardiac disease and blood disorders. In each case, the solution lies in complex 3D engineered environments for cell culture. These colleagues make it clear that existing 3D scaffolds fail to provide the required complex orientational and spatial anisotropy, and are limited in their ability to impart appropriate biochemical and mechanical cues.
I have a strong track record in this area. A particular success has been the use of a freeze drying technology to make collagen based porous implants for the cartilage-bone interface in the knee, which has now been commercialised. The novelty of this proposal lies in the broadening of the established scientific base of this technology to enable biomacromolecular structures with:
(A) controlled and complex pore orientation to mimic many normal multi-oriented tissue structures
(B) compositional and positional control to match varying local biochemical environments,
(C) the attachment of novel peptides designed to control cell behaviour, and
(D) mechanical control at both a local and macroscopic level to provide mechanical cues for cells.
These will be complemented by the development of
(E) robust characterisation methodologies for the structures created.
These advances will then be employed in each of the medical areas above.
This approach is highly interdisciplinary. Existing working relationships with experts in each medical field will guarantee expertise and licensed facilities in the required biological disciplines. Funds for this proposal would therefore establish a rich hub of mutually beneficial research and opportunities for cross-disciplinary sharing of expertise."
Summary
"This proposal develops a unified, underpinning technology to create novel, complex and biomimetic 3D environments for the control of tissue growth. As director of Cambridge Centre for Medical Materials, I have recently been approached by medical colleagues to help to solve important problems in the separate therapeutic areas of breast cancer, cardiac disease and blood disorders. In each case, the solution lies in complex 3D engineered environments for cell culture. These colleagues make it clear that existing 3D scaffolds fail to provide the required complex orientational and spatial anisotropy, and are limited in their ability to impart appropriate biochemical and mechanical cues.
I have a strong track record in this area. A particular success has been the use of a freeze drying technology to make collagen based porous implants for the cartilage-bone interface in the knee, which has now been commercialised. The novelty of this proposal lies in the broadening of the established scientific base of this technology to enable biomacromolecular structures with:
(A) controlled and complex pore orientation to mimic many normal multi-oriented tissue structures
(B) compositional and positional control to match varying local biochemical environments,
(C) the attachment of novel peptides designed to control cell behaviour, and
(D) mechanical control at both a local and macroscopic level to provide mechanical cues for cells.
These will be complemented by the development of
(E) robust characterisation methodologies for the structures created.
These advances will then be employed in each of the medical areas above.
This approach is highly interdisciplinary. Existing working relationships with experts in each medical field will guarantee expertise and licensed facilities in the required biological disciplines. Funds for this proposal would therefore establish a rich hub of mutually beneficial research and opportunities for cross-disciplinary sharing of expertise."
Max ERC Funding
2 486 267 €
Duration
Start date: 2013-04-01, End date: 2018-03-31
Project acronym 3DAddChip
Project Additive manufacturing of 2D nanomaterials for on-chip technologies
Researcher (PI) Cecilia Mattevi
Host Institution (HI) IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Call Details Consolidator Grant (CoG), PE8, ERC-2018-COG
Summary The realization of “the internet of things” is inevitably constrained at the level of miniaturization that can be achieved in the electronic devices. A variety of technologies are now going through a process of miniaturization from micro-electromechanical systems (MEMS) to biomedical sensors, and actuators. The ultimate goal is to combine several components in an individual multifunctional platform, realizing on-chip technology. Devices have to be constrained to small footprints and exhibit high performance. Thus, the miniaturization process requires the introduction of new manufacturing processes to fabricate devices in the 3D space over small areas. 3D printing via robocasting is emerging as a new manufacturing technique, which allows shaping virtually any materials from polymers to ceramic and metals into complex architectures.
The goal of this research is to establish a 3D printing paradigm to produce miniaturized complex shape devices with diversified functions for on-chip technologies adaptable to “smart environment” such as flexible substrates, smart textiles and biomedical sensors. The elementary building blocks of the devices will be two-dimensional nanomaterials, which present unique optical, electrical, chemical and mechanical properties. The synergistic combination of the intrinsic characteristics of the 2D nanomaterials and the specific 3D architecture will enable advanced performance of the 3D printed objects. This research programme will demonstrate 3D miniaturized energy storage and energy conversion units fabricated with inks produced using a pilot plant. These units are essential components of any on-chip platform as they ensure energy autonomy via self-powering. Ultimately, this research will initiate new technologies based on miniaturized 3D devices.
Summary
The realization of “the internet of things” is inevitably constrained at the level of miniaturization that can be achieved in the electronic devices. A variety of technologies are now going through a process of miniaturization from micro-electromechanical systems (MEMS) to biomedical sensors, and actuators. The ultimate goal is to combine several components in an individual multifunctional platform, realizing on-chip technology. Devices have to be constrained to small footprints and exhibit high performance. Thus, the miniaturization process requires the introduction of new manufacturing processes to fabricate devices in the 3D space over small areas. 3D printing via robocasting is emerging as a new manufacturing technique, which allows shaping virtually any materials from polymers to ceramic and metals into complex architectures.
The goal of this research is to establish a 3D printing paradigm to produce miniaturized complex shape devices with diversified functions for on-chip technologies adaptable to “smart environment” such as flexible substrates, smart textiles and biomedical sensors. The elementary building blocks of the devices will be two-dimensional nanomaterials, which present unique optical, electrical, chemical and mechanical properties. The synergistic combination of the intrinsic characteristics of the 2D nanomaterials and the specific 3D architecture will enable advanced performance of the 3D printed objects. This research programme will demonstrate 3D miniaturized energy storage and energy conversion units fabricated with inks produced using a pilot plant. These units are essential components of any on-chip platform as they ensure energy autonomy via self-powering. Ultimately, this research will initiate new technologies based on miniaturized 3D devices.
Max ERC Funding
1 999 968 €
Duration
Start date: 2019-09-01, End date: 2024-08-31
Project acronym ACB
Project The Analytic Conformal Bootstrap
Researcher (PI) Luis Fernando ALDAY
Host Institution (HI) THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Call Details Advanced Grant (AdG), PE2, ERC-2017-ADG
Summary The aim of the present proposal is to establish a research team developing and exploiting innovative techniques to study conformal field theories (CFT) analytically. Our approach does not rely on a Lagrangian description but on symmetries and consistency conditions. As such it applies to any CFT, offering a unified framework to study generic CFTs analytically. The initial implementation of this program has already led to striking new results and insights for both Lagrangian and non-Lagrangian CFTs.
The overarching aims of my team will be: To develop an analytic bootstrap program for CFTs in general dimensions; to complement these techniques with more traditional methods and develop a systematic machinery to obtain analytic results for generic CFTs; and to use these results to gain new insights into the mathematical structure of the space of quantum field theories.
The proposal will bring together researchers from different areas. The objectives in brief are:
1) Develop an alternative to Feynman diagram computations for Lagrangian CFTs.
2) Develop a machinery to compute loops for QFT on AdS, with and without gravity.
3) Develop an analytic approach to non-perturbative N=4 SYM and other CFTs.
4) Determine the space of all CFTs.
5) Gain new insights into the mathematical structure of the space of quantum field theories.
The outputs of this proposal will include a new way of doing perturbative computations based on symmetries; a constructive derivation of the AdS/CFT duality; new analytic techniques to attack strongly coupled systems and invaluable new lessons about the space of CFTs and QFTs.
Success in this research will lead to a completely new, unified way to view and solve CFTs, with a huge impact on several branches of physics and mathematics.
Summary
The aim of the present proposal is to establish a research team developing and exploiting innovative techniques to study conformal field theories (CFT) analytically. Our approach does not rely on a Lagrangian description but on symmetries and consistency conditions. As such it applies to any CFT, offering a unified framework to study generic CFTs analytically. The initial implementation of this program has already led to striking new results and insights for both Lagrangian and non-Lagrangian CFTs.
The overarching aims of my team will be: To develop an analytic bootstrap program for CFTs in general dimensions; to complement these techniques with more traditional methods and develop a systematic machinery to obtain analytic results for generic CFTs; and to use these results to gain new insights into the mathematical structure of the space of quantum field theories.
The proposal will bring together researchers from different areas. The objectives in brief are:
1) Develop an alternative to Feynman diagram computations for Lagrangian CFTs.
2) Develop a machinery to compute loops for QFT on AdS, with and without gravity.
3) Develop an analytic approach to non-perturbative N=4 SYM and other CFTs.
4) Determine the space of all CFTs.
5) Gain new insights into the mathematical structure of the space of quantum field theories.
The outputs of this proposal will include a new way of doing perturbative computations based on symmetries; a constructive derivation of the AdS/CFT duality; new analytic techniques to attack strongly coupled systems and invaluable new lessons about the space of CFTs and QFTs.
Success in this research will lead to a completely new, unified way to view and solve CFTs, with a huge impact on several branches of physics and mathematics.
Max ERC Funding
2 171 483 €
Duration
Start date: 2018-12-01, End date: 2023-11-30
Project acronym ACOULOMODE
Project Advanced coupling of low order combustor simulations with thermoacoustic modelling and controller design
Researcher (PI) Aimee Morgans
Host Institution (HI) IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Call Details Starting Grant (StG), PE8, ERC-2012-StG_20111012
Summary "Combustion is essential to the world’s energy generation and transport needs, and will remain so for the foreseeable future. Mitigating its impact on the climate and human health, by reducing its associated emissions, is thus a priority. One significant challenge for gas-turbine combustion is combustion instability, which is currently inhibiting reductions in NOx emissions (these damage human health via a deterioration in air quality). Combustion instability is caused by a two-way coupling between unsteady combustion and acoustic waves - the large pressure oscillations that result can cause substantial mechanical damage. Currently, the lack of fast, accurate modelling tools for combustion instability, and the lack of reliable ways of suppressing it are severely hindering reductions in NOx emissions.
This proposal aims to make step improvements in both fast, accurate modelling of combustion instability, and in developing reliable active control strategies for its suppression. It will achieve this by coupling low order combustor models (these are fast, simplified models for simulating combustion instability) with advances in analytical modelling, CFD simulation, reduced order modelling and control theory tools. In particular:
* important advances in accurately incorporating the effect of entropy waves (temperature variations resulting from unsteady combustion) and non-linear flame models will be made;
* new active control strategies for achieving reliable suppression of combustion instability, including from within limit cycle oscillations, will be developed;
* an open-source low order combustor modelling tool will be developed and widely disseminated, opening access to researchers worldwide and improving communications between the fields of thermoacoustics and control theory.
Thus the proposal aims to use analytical and computational methods to contribute to achieving low NOx gas-turbine combustion, without the penalty of damaging combustion instability."
Summary
"Combustion is essential to the world’s energy generation and transport needs, and will remain so for the foreseeable future. Mitigating its impact on the climate and human health, by reducing its associated emissions, is thus a priority. One significant challenge for gas-turbine combustion is combustion instability, which is currently inhibiting reductions in NOx emissions (these damage human health via a deterioration in air quality). Combustion instability is caused by a two-way coupling between unsteady combustion and acoustic waves - the large pressure oscillations that result can cause substantial mechanical damage. Currently, the lack of fast, accurate modelling tools for combustion instability, and the lack of reliable ways of suppressing it are severely hindering reductions in NOx emissions.
This proposal aims to make step improvements in both fast, accurate modelling of combustion instability, and in developing reliable active control strategies for its suppression. It will achieve this by coupling low order combustor models (these are fast, simplified models for simulating combustion instability) with advances in analytical modelling, CFD simulation, reduced order modelling and control theory tools. In particular:
* important advances in accurately incorporating the effect of entropy waves (temperature variations resulting from unsteady combustion) and non-linear flame models will be made;
* new active control strategies for achieving reliable suppression of combustion instability, including from within limit cycle oscillations, will be developed;
* an open-source low order combustor modelling tool will be developed and widely disseminated, opening access to researchers worldwide and improving communications between the fields of thermoacoustics and control theory.
Thus the proposal aims to use analytical and computational methods to contribute to achieving low NOx gas-turbine combustion, without the penalty of damaging combustion instability."
Max ERC Funding
1 489 309 €
Duration
Start date: 2013-01-01, End date: 2017-12-31
Project acronym ActiveWindFarms
Project Active Wind Farms: Optimization and Control of Atmospheric Energy Extraction in Gigawatt Wind Farms
Researcher (PI) Johan Meyers
Host Institution (HI) KATHOLIEKE UNIVERSITEIT LEUVEN
Call Details Starting Grant (StG), PE8, ERC-2012-StG_20111012
Summary With the recognition that wind energy will become an important contributor to the world’s energy portfolio, several wind farms with a capacity of over 1 gigawatt are in planning phase. In the past, engineering of wind farms focused on a bottom-up approach, in which atmospheric wind availability was considered to be fixed by climate and weather. However, farms of gigawatt size slow down the Atmospheric Boundary Layer (ABL) as a whole, reducing the availability of wind at turbine hub height. In Denmark’s large off-shore farms, this leads to underperformance of turbines which can reach levels of 40%–50% compared to the same turbine in a lone-standing case. For large wind farms, the vertical structure and turbulence physics of the flow in the ABL become crucial ingredients in their design and operation. This introduces a new set of scientific challenges related to the design and control of large wind farms. The major ambition of the present research proposal is to employ optimal control techniques to control the interaction between large wind farms and the ABL, and optimize overall farm-power extraction. Individual turbines are used as flow actuators by dynamically pitching their blades using time scales ranging between 10 to 500 seconds. The application of such control efforts on the atmospheric boundary layer has never been attempted before, and introduces flow control on a physical scale which is currently unprecedented. The PI possesses a unique combination of expertise and tools enabling these developments: efficient parallel large-eddy simulations of wind farms, multi-scale turbine modeling, and gradient-based optimization in large optimization-parameter spaces using adjoint formulations. To ensure a maximum impact on the wind-engineering field, the project aims at optimal control, experimental wind-tunnel validation, and at including multi-disciplinary aspects, related to structural mechanics, power quality, and controller design.
Summary
With the recognition that wind energy will become an important contributor to the world’s energy portfolio, several wind farms with a capacity of over 1 gigawatt are in planning phase. In the past, engineering of wind farms focused on a bottom-up approach, in which atmospheric wind availability was considered to be fixed by climate and weather. However, farms of gigawatt size slow down the Atmospheric Boundary Layer (ABL) as a whole, reducing the availability of wind at turbine hub height. In Denmark’s large off-shore farms, this leads to underperformance of turbines which can reach levels of 40%–50% compared to the same turbine in a lone-standing case. For large wind farms, the vertical structure and turbulence physics of the flow in the ABL become crucial ingredients in their design and operation. This introduces a new set of scientific challenges related to the design and control of large wind farms. The major ambition of the present research proposal is to employ optimal control techniques to control the interaction between large wind farms and the ABL, and optimize overall farm-power extraction. Individual turbines are used as flow actuators by dynamically pitching their blades using time scales ranging between 10 to 500 seconds. The application of such control efforts on the atmospheric boundary layer has never been attempted before, and introduces flow control on a physical scale which is currently unprecedented. The PI possesses a unique combination of expertise and tools enabling these developments: efficient parallel large-eddy simulations of wind farms, multi-scale turbine modeling, and gradient-based optimization in large optimization-parameter spaces using adjoint formulations. To ensure a maximum impact on the wind-engineering field, the project aims at optimal control, experimental wind-tunnel validation, and at including multi-disciplinary aspects, related to structural mechanics, power quality, and controller design.
Max ERC Funding
1 499 241 €
Duration
Start date: 2012-10-01, End date: 2017-09-30
Project acronym AEROSPACEPHYS
Project Multiphysics models and simulations for reacting and plasma flows applied to the space exploration program
Researcher (PI) Thierry Edouard Bertrand Magin
Host Institution (HI) INSTITUT VON KARMAN DE DYNAMIQUE DES FLUIDES
Call Details Starting Grant (StG), PE8, ERC-2010-StG_20091028
Summary Space exploration is one of boldest and most exciting endeavors that humanity has undertaken, and it holds enormous promise for the future. Our next challenges for the spatial conquest include bringing back samples to Earth by means of robotic missions and continuing the manned exploration program, which aims at sending human beings to Mars and bring them home safely. Inaccurate prediction of the heat-flux to the surface of the spacecraft heat shield can be fatal for the crew or the success of a robotic mission. This quantity is estimated during the design phase. An accurate prediction is a particularly complex task, regarding modelling of the following phenomena that are potential “mission killers:” 1) Radiation of the plasma in the shock layer, 2) Complex surface chemistry on the thermal protection material, 3) Flow transition from laminar to turbulent. Our poor understanding of the coupled mechanisms of radiation, ablation, and transition leads to the difficulties in flux prediction. To avoid failure and ensure safety of the astronauts and payload, engineers resort to “safety factors” to determine the thickness of the heat shield, at the expense of the mass of embarked payload. Thinking out of the box and basic research are thus necessary for advancements of the models that will better define the environment and requirements for the design and safe operation of tomorrow’s space vehicles and planetary probes for the manned space exploration. The three basic ingredients for predictive science are: 1) Physico-chemical models, 2) Computational methods, 3) Experimental data. We propose to follow a complementary approach for prediction. The proposed research aims at: “Integrating new advanced physico-chemical models and computational methods, based on a multidisciplinary approach developed together with physicists, chemists, and applied mathematicians, to create a top-notch multiphysics and multiscale numerical platform for simulations of planetary atmosphere entries, crucial to the new challenges of the manned space exploration program. Experimental data will also be used for validation, following state-of-the-art uncertainty quantification methods.”
Summary
Space exploration is one of boldest and most exciting endeavors that humanity has undertaken, and it holds enormous promise for the future. Our next challenges for the spatial conquest include bringing back samples to Earth by means of robotic missions and continuing the manned exploration program, which aims at sending human beings to Mars and bring them home safely. Inaccurate prediction of the heat-flux to the surface of the spacecraft heat shield can be fatal for the crew or the success of a robotic mission. This quantity is estimated during the design phase. An accurate prediction is a particularly complex task, regarding modelling of the following phenomena that are potential “mission killers:” 1) Radiation of the plasma in the shock layer, 2) Complex surface chemistry on the thermal protection material, 3) Flow transition from laminar to turbulent. Our poor understanding of the coupled mechanisms of radiation, ablation, and transition leads to the difficulties in flux prediction. To avoid failure and ensure safety of the astronauts and payload, engineers resort to “safety factors” to determine the thickness of the heat shield, at the expense of the mass of embarked payload. Thinking out of the box and basic research are thus necessary for advancements of the models that will better define the environment and requirements for the design and safe operation of tomorrow’s space vehicles and planetary probes for the manned space exploration. The three basic ingredients for predictive science are: 1) Physico-chemical models, 2) Computational methods, 3) Experimental data. We propose to follow a complementary approach for prediction. The proposed research aims at: “Integrating new advanced physico-chemical models and computational methods, based on a multidisciplinary approach developed together with physicists, chemists, and applied mathematicians, to create a top-notch multiphysics and multiscale numerical platform for simulations of planetary atmosphere entries, crucial to the new challenges of the manned space exploration program. Experimental data will also be used for validation, following state-of-the-art uncertainty quantification methods.”
Max ERC Funding
1 494 892 €
Duration
Start date: 2010-09-01, End date: 2015-08-31
Project acronym AFFINITY
Project Actuation of Ferromagnetic Fibre Networks to improve Implant Longevity
Researcher (PI) Athina Markaki
Host Institution (HI) THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Call Details Starting Grant (StG), PE8, ERC-2009-StG
Summary This proposal is for an exploratory study into a radical new approach to the problem of orthopaedic implant loosening. Such loosening commonly occurs because the joint between the implant and the surrounding bone is insufficiently strong and durable. It is a serious problem both for implants cemented to the bone and for those dependent on bone in-growth into a rough/porous implant surface. In the latter case, the main problem is commonly that bone in-growth is insufficiently rapid or deep for a strong bond to be established. The idea proposed in this work is that the implant should have a highly porous surface layer, made by bonding ferromagnetic fibres together, into which bone tissue growth would occur. During the post-operative period, application of a magnetic field will cause the fibre network to deform elastically, as individual fibres tend to align with the field. This will impose strains on the bone tissue as it grows into the fibre network. Such mechanical deformation is known to be highly beneficial in promoting bone growth, providing the associated strain lies in a certain range (~0.1%). Preliminary work, involving both model development and experimental studies on the effect of magnetic fields on fibre networks, has suggested that beneficial therapeutic effects can be induced using field strengths no greater than those already employed for diagnostic purposes. A comprehensive 5-year, highly inter-disciplinary programme is planned, encompassing processing, network architecture characterisation, magneto-mechanical response investigations, various modelling activities and systematic in vitro experimentation to establish whether magneto-mechanical Actuation of Ferromagnetic Fibre Networks shows promise as a new therapeutic approach to improve implant longevity.
Summary
This proposal is for an exploratory study into a radical new approach to the problem of orthopaedic implant loosening. Such loosening commonly occurs because the joint between the implant and the surrounding bone is insufficiently strong and durable. It is a serious problem both for implants cemented to the bone and for those dependent on bone in-growth into a rough/porous implant surface. In the latter case, the main problem is commonly that bone in-growth is insufficiently rapid or deep for a strong bond to be established. The idea proposed in this work is that the implant should have a highly porous surface layer, made by bonding ferromagnetic fibres together, into which bone tissue growth would occur. During the post-operative period, application of a magnetic field will cause the fibre network to deform elastically, as individual fibres tend to align with the field. This will impose strains on the bone tissue as it grows into the fibre network. Such mechanical deformation is known to be highly beneficial in promoting bone growth, providing the associated strain lies in a certain range (~0.1%). Preliminary work, involving both model development and experimental studies on the effect of magnetic fields on fibre networks, has suggested that beneficial therapeutic effects can be induced using field strengths no greater than those already employed for diagnostic purposes. A comprehensive 5-year, highly inter-disciplinary programme is planned, encompassing processing, network architecture characterisation, magneto-mechanical response investigations, various modelling activities and systematic in vitro experimentation to establish whether magneto-mechanical Actuation of Ferromagnetic Fibre Networks shows promise as a new therapeutic approach to improve implant longevity.
Max ERC Funding
1 442 756 €
Duration
Start date: 2010-01-01, End date: 2015-11-30
Project acronym AFIRMATIVE
Project Acoustic-Flow Interaction Models for Advancing Thermoacoustic Instability prediction in Very low Emission combustors
Researcher (PI) Aimee MORGANS
Host Institution (HI) IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Call Details Consolidator Grant (CoG), PE8, ERC-2017-COG
Summary Gas turbines are an essential ingredient in the long-term energy and aviation mix. They are flexible, offer fast start-up and the ability to burn renewable-generated fuels. However, they generate NOx emissions, which cause air pollution and damage human health, and reducing these is an air quality imperative. A major hurdle to this is that lean premixed combustion, essential for further NOx emission reductions, is highly susceptible to thermoacoustic instability. This is caused by a two-way coupling between unsteady combustion and acoustic waves, and the resulting large pressure oscillations can cause severe mechanical damage. Computational methods for predicting thermoacoustic instability, fast and accurate enough to be used as part of the industrial design process, are urgently needed.
The only computational methods with the prospect of being fast enough are those based on coupled treatment of the acoustic waves and unsteady combustion. These exploit the amenity of the acoustic waves to analytical modelling, allowing costly simulations to be directed only at the more complex flame. They show real promise: my group recently demonstrated the first accurate coupled predictions for lab-scale combustors. The method does not yet extend to industrial combustors, the more complex flow-fields in these rendering current acoustic models overly-simplistic. I propose to comprehensively overhaul acoustic models across the entirety of the combustor, accounting for real and important acoustic-flow interactions. These new models will offer the breakthrough prospect of extending efficient, accurate predictive capability to industrial combustors, which has a real chance of facilitating future, instability free, very low NOx gas turbines.
Summary
Gas turbines are an essential ingredient in the long-term energy and aviation mix. They are flexible, offer fast start-up and the ability to burn renewable-generated fuels. However, they generate NOx emissions, which cause air pollution and damage human health, and reducing these is an air quality imperative. A major hurdle to this is that lean premixed combustion, essential for further NOx emission reductions, is highly susceptible to thermoacoustic instability. This is caused by a two-way coupling between unsteady combustion and acoustic waves, and the resulting large pressure oscillations can cause severe mechanical damage. Computational methods for predicting thermoacoustic instability, fast and accurate enough to be used as part of the industrial design process, are urgently needed.
The only computational methods with the prospect of being fast enough are those based on coupled treatment of the acoustic waves and unsteady combustion. These exploit the amenity of the acoustic waves to analytical modelling, allowing costly simulations to be directed only at the more complex flame. They show real promise: my group recently demonstrated the first accurate coupled predictions for lab-scale combustors. The method does not yet extend to industrial combustors, the more complex flow-fields in these rendering current acoustic models overly-simplistic. I propose to comprehensively overhaul acoustic models across the entirety of the combustor, accounting for real and important acoustic-flow interactions. These new models will offer the breakthrough prospect of extending efficient, accurate predictive capability to industrial combustors, which has a real chance of facilitating future, instability free, very low NOx gas turbines.
Max ERC Funding
1 985 288 €
Duration
Start date: 2018-06-01, End date: 2023-05-31
Project acronym ALORS
Project Advanced Lagrangian Optimization, Receptivity and Sensitivity analysis applied to industrial situations
Researcher (PI) Matthew Pudan Juniper
Host Institution (HI) THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Call Details Starting Grant (StG), PE8, ERC-2010-StG_20091028
Summary In the last ten years there has been a surge of interest in non-modal analysis applied to canonical problems in fundamental fluid mechanics. Even in simple flows, the stability behaviour predicted by non-modal analysis can be completely different from and far more accurate than that predicted by conventional eigenvalue analysis.
As well as being more accurate, the tools of non-modal analysis, such as Lagrangian optimization, are very versatile. Furthermore, the outputs, such as receptivity and sensitivity maps of a flow, provide powerful insight for engineers. They describe where a flow is most receptive to forcing or where the flow is most sensitive to modification.
The application of non-modal analysis to canonical problems has set the scene for step changes in engineering practice in fluid mechanics and thermoacoustics. The technical objectives of this proposal are to apply non-modal analysis to high Reynolds number flows, reacting flows and thermoacoustic systems, to compare theoretical predictions with experimental measurements and to embed these techniques within an industrial design tool that has already been developed by the group.
This research group s vision is that future generations of engineering CFD tools will contain modules that can perform non-modal analysis. The generalized approach proposed here, combined with challenging scientific and engineering examples that are backed up by experimental evidence, will make this possible and demonstrate it to a wider engineering community.
Summary
In the last ten years there has been a surge of interest in non-modal analysis applied to canonical problems in fundamental fluid mechanics. Even in simple flows, the stability behaviour predicted by non-modal analysis can be completely different from and far more accurate than that predicted by conventional eigenvalue analysis.
As well as being more accurate, the tools of non-modal analysis, such as Lagrangian optimization, are very versatile. Furthermore, the outputs, such as receptivity and sensitivity maps of a flow, provide powerful insight for engineers. They describe where a flow is most receptive to forcing or where the flow is most sensitive to modification.
The application of non-modal analysis to canonical problems has set the scene for step changes in engineering practice in fluid mechanics and thermoacoustics. The technical objectives of this proposal are to apply non-modal analysis to high Reynolds number flows, reacting flows and thermoacoustic systems, to compare theoretical predictions with experimental measurements and to embed these techniques within an industrial design tool that has already been developed by the group.
This research group s vision is that future generations of engineering CFD tools will contain modules that can perform non-modal analysis. The generalized approach proposed here, combined with challenging scientific and engineering examples that are backed up by experimental evidence, will make this possible and demonstrate it to a wider engineering community.
Max ERC Funding
1 301 196 €
Duration
Start date: 2010-12-01, End date: 2016-06-30
Project acronym ALUFIX
Project Friction stir processing based local damage mitigation and healing in aluminium alloys
Researcher (PI) Aude SIMAR
Host Institution (HI) UNIVERSITE CATHOLIQUE DE LOUVAIN
Call Details Starting Grant (StG), PE8, ERC-2016-STG
Summary ALUFIX proposes an original strategy for the development of aluminium-based materials involving damage mitigation and extrinsic self-healing concepts exploiting the new opportunities of the solid-state friction stir process. Friction stir processing locally extrudes and drags material from the front to the back and around the tool pin. It involves short duration at moderate temperatures (typically 80% of the melting temperature), fast cooling rates and large plastic deformations leading to far out-of-equilibrium microstructures. The idea is that commercial aluminium alloys can be locally improved and healed in regions of stress concentration where damage is likely to occur. Self-healing in metal-based materials is still in its infancy and existing strategies can hardly be extended to applications. Friction stir processing can enhance the damage and fatigue resistance of aluminium alloys by microstructure homogenisation and refinement. In parallel, friction stir processing can be used to integrate secondary phases in an aluminium matrix. In the ALUFIX project, healing phases will thus be integrated in aluminium in addition to refining and homogenising the microstructure. The “local stress management strategy” favours crack closure and crack deviation at the sub-millimetre scale thanks to a controlled residual stress field. The “transient liquid healing agent” strategy involves the in-situ generation of an out-of-equilibrium compositionally graded microstructure at the aluminium/healing agent interface capable of liquid-phase healing after a thermal treatment. Along the road, a variety of new scientific questions concerning the damage mechanisms will have to be addressed.
Summary
ALUFIX proposes an original strategy for the development of aluminium-based materials involving damage mitigation and extrinsic self-healing concepts exploiting the new opportunities of the solid-state friction stir process. Friction stir processing locally extrudes and drags material from the front to the back and around the tool pin. It involves short duration at moderate temperatures (typically 80% of the melting temperature), fast cooling rates and large plastic deformations leading to far out-of-equilibrium microstructures. The idea is that commercial aluminium alloys can be locally improved and healed in regions of stress concentration where damage is likely to occur. Self-healing in metal-based materials is still in its infancy and existing strategies can hardly be extended to applications. Friction stir processing can enhance the damage and fatigue resistance of aluminium alloys by microstructure homogenisation and refinement. In parallel, friction stir processing can be used to integrate secondary phases in an aluminium matrix. In the ALUFIX project, healing phases will thus be integrated in aluminium in addition to refining and homogenising the microstructure. The “local stress management strategy” favours crack closure and crack deviation at the sub-millimetre scale thanks to a controlled residual stress field. The “transient liquid healing agent” strategy involves the in-situ generation of an out-of-equilibrium compositionally graded microstructure at the aluminium/healing agent interface capable of liquid-phase healing after a thermal treatment. Along the road, a variety of new scientific questions concerning the damage mechanisms will have to be addressed.
Max ERC Funding
1 497 447 €
Duration
Start date: 2017-01-01, End date: 2021-12-31
Project acronym ANTI-ATOM
Project Many-body theory of antimatter interactions with atoms, molecules and condensed matter
Researcher (PI) Dermot GREEN
Host Institution (HI) THE QUEEN'S UNIVERSITY OF BELFAST
Call Details Starting Grant (StG), PE2, ERC-2018-STG
Summary The ability of positrons to annihilate with electrons, producing characteristic gamma rays, gives them important use in medicine via positron-emission tomography (PET), diagnostics of industrially-important materials, and in elucidating astrophysical phenomena. Moreover, the fundamental interactions of positrons and positronium (Ps) with atoms, molecules and condensed matter are currently under intensive study in numerous international laboratories, to illuminate collision phenomena and perform precision tests of fundamental laws.
Proper interpretation and development of these costly and difficult experiments requires accurate calculations of low-energy positron and Ps interactions with normal matter. These systems, however, involve strong correlations, e.g., polarisation of the atom and virtual-Ps formation (where an atomic electron tunnels to the positron): they significantly effect positron- and Ps-atom/molecule interactions, e.g., enhancing annihilation rates by many orders of magnitude, and making the accurate description of these systems a challenging many-body problem. Current theoretical capability lags severely behind that of experiment. Major theoretical and computational developments are required to bridge the gap.
One powerful method, which accounts for the correlations in a natural, transparent and systematic way, is many-body theory (MBT). Building on my expertise in the field, I propose to develop new MBT to deliver unique and unrivalled capability in theory and computation of low-energy positron and Ps interactions with atoms, molecules, and condensed matter. The ambitious programme will provide the basic understanding required to interpret and develop the fundamental experiments, antimatter-based materials science techniques, and wider technologies, e.g., (PET), and more broadly, potentially revolutionary and generally applicable computational methodologies that promise to define a new level of high-precision in atomic-MBT calculations.
Summary
The ability of positrons to annihilate with electrons, producing characteristic gamma rays, gives them important use in medicine via positron-emission tomography (PET), diagnostics of industrially-important materials, and in elucidating astrophysical phenomena. Moreover, the fundamental interactions of positrons and positronium (Ps) with atoms, molecules and condensed matter are currently under intensive study in numerous international laboratories, to illuminate collision phenomena and perform precision tests of fundamental laws.
Proper interpretation and development of these costly and difficult experiments requires accurate calculations of low-energy positron and Ps interactions with normal matter. These systems, however, involve strong correlations, e.g., polarisation of the atom and virtual-Ps formation (where an atomic electron tunnels to the positron): they significantly effect positron- and Ps-atom/molecule interactions, e.g., enhancing annihilation rates by many orders of magnitude, and making the accurate description of these systems a challenging many-body problem. Current theoretical capability lags severely behind that of experiment. Major theoretical and computational developments are required to bridge the gap.
One powerful method, which accounts for the correlations in a natural, transparent and systematic way, is many-body theory (MBT). Building on my expertise in the field, I propose to develop new MBT to deliver unique and unrivalled capability in theory and computation of low-energy positron and Ps interactions with atoms, molecules, and condensed matter. The ambitious programme will provide the basic understanding required to interpret and develop the fundamental experiments, antimatter-based materials science techniques, and wider technologies, e.g., (PET), and more broadly, potentially revolutionary and generally applicable computational methodologies that promise to define a new level of high-precision in atomic-MBT calculations.
Max ERC Funding
1 318 419 €
Duration
Start date: 2019-02-01, End date: 2024-01-31
Project acronym ANTINEUTRINONOVA
Project Probing Fundamental Physics with Antineutrinos at the NOvA Experiment
Researcher (PI) Jeffrey Hartnell
Host Institution (HI) THE UNIVERSITY OF SUSSEX
Call Details Starting Grant (StG), PE2, ERC-2012-StG_20111012
Summary "This proposal addresses major questions in particle physics that are at the forefront of experimental and theoretical physics research today. The results offered would have far-reaching implications in other fields such as cosmology and could help answer some of the big questions such as why the universe contains so much more matter than antimatter. The research objectives of this proposal are to (i) make world-leading tests of CPT symmetry and (ii) discover the neutrino mass hierarchy and search for indications of leptonic CP violation.
The NOvA long-baseline neutrino oscillation experiment will use a novel ""totally active scintillator design"" for the detector technology and will be exposed to the world's highest power neutrino beam. Building on the first direct observation of muon antineutrino disappearance (that was made by a group founded and led by the PI at the MINOS experiment), tests of CPT symmetry will be performed by looking for differences in the mass squared splittings and mixing angles between neutrinos and antineutrinos. The potential to discover the mass hierarchy is unique to NOvA on the timescale of this proposal due to the long 810 km baseline and the well measured beam of neutrinos and antineutrinos.
This proposal addresses several key challenges in a long-baseline neutrino oscillation experiment with the following tasks: (i) development of a new approach to event energy reconstruction that is expected to have widespread applicability for future neutrino experiments; (ii) undertaking a comprehensive calibration project, exploiting a novel technique developed by the PI, that will be essential to achieving the physics goals; (iii) development of a sophisticated statistical analyses.
The results promised in this proposal surpass the sensitivity to antineutrino oscillation parameters of current 1st generation experiments by at least an order of magnitude, offering wide scope for profound discoveries with implications across disciplines."
Summary
"This proposal addresses major questions in particle physics that are at the forefront of experimental and theoretical physics research today. The results offered would have far-reaching implications in other fields such as cosmology and could help answer some of the big questions such as why the universe contains so much more matter than antimatter. The research objectives of this proposal are to (i) make world-leading tests of CPT symmetry and (ii) discover the neutrino mass hierarchy and search for indications of leptonic CP violation.
The NOvA long-baseline neutrino oscillation experiment will use a novel ""totally active scintillator design"" for the detector technology and will be exposed to the world's highest power neutrino beam. Building on the first direct observation of muon antineutrino disappearance (that was made by a group founded and led by the PI at the MINOS experiment), tests of CPT symmetry will be performed by looking for differences in the mass squared splittings and mixing angles between neutrinos and antineutrinos. The potential to discover the mass hierarchy is unique to NOvA on the timescale of this proposal due to the long 810 km baseline and the well measured beam of neutrinos and antineutrinos.
This proposal addresses several key challenges in a long-baseline neutrino oscillation experiment with the following tasks: (i) development of a new approach to event energy reconstruction that is expected to have widespread applicability for future neutrino experiments; (ii) undertaking a comprehensive calibration project, exploiting a novel technique developed by the PI, that will be essential to achieving the physics goals; (iii) development of a sophisticated statistical analyses.
The results promised in this proposal surpass the sensitivity to antineutrino oscillation parameters of current 1st generation experiments by at least an order of magnitude, offering wide scope for profound discoveries with implications across disciplines."
Max ERC Funding
1 415 848 €
Duration
Start date: 2012-10-01, End date: 2018-09-30
Project acronym APRA
Project Active Polymers for Renewable Functional Actuators
Researcher (PI) Eugene TERENTJEV
Host Institution (HI) THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Call Details Advanced Grant (AdG), PE8, ERC-2017-ADG
Summary The idea of mechanical actuator based on intrinsic material properties of liquid-crystalline elastomers (rather than complex engineering of interacting components) has been understood for 20+ years. The remarkable characteristics of LCE actuation (fully reversible action; large-amplitude, with a stroke of 5%-300%; stress-strain-speed response almost exactly matching the human muscle) make it highly attractive in biomedical engineering, robotics, smart textiles, and other fields. Yet, there is a profound difficulty (bottleneck), which remains the reason why this concept has not found its way into any practical devices & applications. LCE actuation requires alignment (monodomain structure) of the local anisotropy in the permanently crosslinked polymer network - which has been impossible to achieve in any useful large-scale configuration except the flat film, due to the unavoidable restrictions of two competing processes: orientational alignment and network crosslinking.
Recently, we made a breakthrough, developing LCE vitrimers (polymer networks covalently crosslinked by a bond-exchange reaction). Vitrimers are much more stable than other transient elastomer networks, allow easy thermal re-moulding (making the material fully renewable), and permit molding of complex shapes with intricate local alignment (which are impossible in traditional elastomers). This project will bridge from the concept to technology, tuning the material design for robust nematic LCE vitrimers, imparting photo-actuation capacity with a controlled wavelength, and finally utilising them in practical-engineering actuator applications where the reversible mechanical action is stimulated by light, solvent exposure, or more traditionally - heat. These applications include (but not limited to): continuous spinning light-driven motor, tactile dynamic Braille display, capillary pump and toggle flow switch for microfuidics, active textile fibre, and heliotracking filament that always points at the Sun.
Summary
The idea of mechanical actuator based on intrinsic material properties of liquid-crystalline elastomers (rather than complex engineering of interacting components) has been understood for 20+ years. The remarkable characteristics of LCE actuation (fully reversible action; large-amplitude, with a stroke of 5%-300%; stress-strain-speed response almost exactly matching the human muscle) make it highly attractive in biomedical engineering, robotics, smart textiles, and other fields. Yet, there is a profound difficulty (bottleneck), which remains the reason why this concept has not found its way into any practical devices & applications. LCE actuation requires alignment (monodomain structure) of the local anisotropy in the permanently crosslinked polymer network - which has been impossible to achieve in any useful large-scale configuration except the flat film, due to the unavoidable restrictions of two competing processes: orientational alignment and network crosslinking.
Recently, we made a breakthrough, developing LCE vitrimers (polymer networks covalently crosslinked by a bond-exchange reaction). Vitrimers are much more stable than other transient elastomer networks, allow easy thermal re-moulding (making the material fully renewable), and permit molding of complex shapes with intricate local alignment (which are impossible in traditional elastomers). This project will bridge from the concept to technology, tuning the material design for robust nematic LCE vitrimers, imparting photo-actuation capacity with a controlled wavelength, and finally utilising them in practical-engineering actuator applications where the reversible mechanical action is stimulated by light, solvent exposure, or more traditionally - heat. These applications include (but not limited to): continuous spinning light-driven motor, tactile dynamic Braille display, capillary pump and toggle flow switch for microfuidics, active textile fibre, and heliotracking filament that always points at the Sun.
Max ERC Funding
2 012 136 €
Duration
Start date: 2018-10-01, End date: 2023-09-30
Project acronym ARIADNE
Project ARgon ImAging DetectioN chambEr
Researcher (PI) Konstantinos Mavrokoridis
Host Institution (HI) THE UNIVERSITY OF LIVERPOOL
Call Details Starting Grant (StG), PE2, ERC-2015-STG
Summary This proposal outlines a plan to combine Charge Couple Device (CCD) camera technologies with two-phase Liquid Argon Time Projection Chambers (LAr TPCs) utilising THick Gas Electron Multipliers (THGEMs) to evolve a next generation neutrino detector. This will be an entirely new readout option, and will open the prospect of revolutionary discoveries in fundamental particle physics. Furthermore, the Compton imaging power of this technology will be developed, which will have diverse applications in novel medical imaging techniques and detection of concealed nuclear materials.
Colossal LAr TPCs are the future for long-baseline-neutrino-oscillation physics around which the international neutrino community is rallying, with the common goal of discovering new physics beyond the Standard Model, which holds the key to our understanding of phenomena such as dark matter and the matter-antimatter asymmetry.
I have successfully provided a first demonstration of photographic capturing of muon tracks and single gammas interacting in the Liverpool 40 l LAr TPC using a CCD camera and THGEM. I propose an ambitious project of extensive research to mature this innovative LAr optical readout technology. I will construct a 650 l LAr TPC with integrated CCD/THGEM readout, capable of containing sufficient tracking information for full development and characterisation of this novel detector, with the goal of realising this game-changing technology in the planned future giant LAr TPCs. Camera readout can replace the current charge readout technology and associated scalability complications, and the excellent energy thresholds will enhance detector performance as well as extend research avenues to lower energy fundamental physics.
Also, I will explore the Compton imaging capability of LAr CCD/THGEM technology; the superiority of the energy threshold and spatial resolution of this system can offer significant advancement to medical imaging and the detection of concealed nuclear materials.
Summary
This proposal outlines a plan to combine Charge Couple Device (CCD) camera technologies with two-phase Liquid Argon Time Projection Chambers (LAr TPCs) utilising THick Gas Electron Multipliers (THGEMs) to evolve a next generation neutrino detector. This will be an entirely new readout option, and will open the prospect of revolutionary discoveries in fundamental particle physics. Furthermore, the Compton imaging power of this technology will be developed, which will have diverse applications in novel medical imaging techniques and detection of concealed nuclear materials.
Colossal LAr TPCs are the future for long-baseline-neutrino-oscillation physics around which the international neutrino community is rallying, with the common goal of discovering new physics beyond the Standard Model, which holds the key to our understanding of phenomena such as dark matter and the matter-antimatter asymmetry.
I have successfully provided a first demonstration of photographic capturing of muon tracks and single gammas interacting in the Liverpool 40 l LAr TPC using a CCD camera and THGEM. I propose an ambitious project of extensive research to mature this innovative LAr optical readout technology. I will construct a 650 l LAr TPC with integrated CCD/THGEM readout, capable of containing sufficient tracking information for full development and characterisation of this novel detector, with the goal of realising this game-changing technology in the planned future giant LAr TPCs. Camera readout can replace the current charge readout technology and associated scalability complications, and the excellent energy thresholds will enhance detector performance as well as extend research avenues to lower energy fundamental physics.
Also, I will explore the Compton imaging capability of LAr CCD/THGEM technology; the superiority of the energy threshold and spatial resolution of this system can offer significant advancement to medical imaging and the detection of concealed nuclear materials.
Max ERC Funding
1 837 911 €
Duration
Start date: 2016-03-01, End date: 2021-02-28
Project acronym ASTEX
Project Attosecond Science by Transmission and Emission of X-rays
Researcher (PI) Jonathan Philip Marangos
Host Institution (HI) IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Call Details Advanced Grant (AdG), PE2, ERC-2011-ADG_20110209
Summary "This is a programme of advanced research with potential for high scientific impact and applications to areas of great strategic importance such as renewable energy and biomolecular technology. The aim is to develop and apply a combination of cutting-edge tools to observe and understand dynamics in molecules and condensed phase matter with attosecond temporal and nanometre spatial resolutions. The programme, will exploit two new types of measurements that my group have already begun to develop: high harmonic generation (HHG) spectroscopy and attosecond absorption pump-probe spectroscopy, and will apply them to the measurement of attosecond electron dynamics in large molecules and the condensed phase. These methods rely upon the emission and transmission of soft X-ray attosecond fields that make accessible measurement not only of larger molecules in the gas phase but also thin (micron to nanometre) samples in the condensed phase. This is a research project that will open new frontiers both experimentally and theoretically. The challenge of this research is high and will be met by a concerted programme that is well matched to my teams experimental and theoretical expertise in attosecond physics, ultrafast intense-field science, soft X-ray techniques and advanced techniques for creating gaseous and condensed phase samples."
Summary
"This is a programme of advanced research with potential for high scientific impact and applications to areas of great strategic importance such as renewable energy and biomolecular technology. The aim is to develop and apply a combination of cutting-edge tools to observe and understand dynamics in molecules and condensed phase matter with attosecond temporal and nanometre spatial resolutions. The programme, will exploit two new types of measurements that my group have already begun to develop: high harmonic generation (HHG) spectroscopy and attosecond absorption pump-probe spectroscopy, and will apply them to the measurement of attosecond electron dynamics in large molecules and the condensed phase. These methods rely upon the emission and transmission of soft X-ray attosecond fields that make accessible measurement not only of larger molecules in the gas phase but also thin (micron to nanometre) samples in the condensed phase. This is a research project that will open new frontiers both experimentally and theoretically. The challenge of this research is high and will be met by a concerted programme that is well matched to my teams experimental and theoretical expertise in attosecond physics, ultrafast intense-field science, soft X-ray techniques and advanced techniques for creating gaseous and condensed phase samples."
Max ERC Funding
2 344 390 €
Duration
Start date: 2012-04-01, End date: 2017-03-31
Project acronym BACKTOBACK
Project Engineering Solutions for Back Pain: Simulation of Patient Variance
Researcher (PI) Ruth Wilcox
Host Institution (HI) UNIVERSITY OF LEEDS
Call Details Starting Grant (StG), PE8, ERC-2012-StG_20111012
Summary Back pain affects eight out of ten adults during their lifetime. It a huge economic burden on society, estimated to cost as much as 1-2% of gross national product in several European countries. Treatments for back pain have lower levels of success and are not as technologically mature as those for other musculoskeletal disorders such as hip and knee replacement. This application proposes to tackle one of the major barriers to the development of better surgical treatments for back pain.
At present, new spinal devices are commonly assessed in isolation in the laboratory under standardised conditions that do not represent the variation across the patient population. Consequently many interventions have failed during clinical trials or have proved to have poor long term success rates.
Using a combination of computational and experimental models, a new testing methodology will be developed that will enable the variation between patients to be simulated for the first time. This will enable spinal implants and therapies to be more robustly evaluated across a virtual patient population prior to clinical trial. The tools developed will be used in collaboration with clinicians and basic scientists to develop and, crucially, optimise new treatments that reduce back pain whilst preserving the unique functions of the spine.
If successful, this approach could be translated to evaluate and optimise emerging minimally invasive treatments in other joints such as the hip and knee. Research in the spine could then, for the first time, lead rather than follow that undertaken in other branches of orthopaedics.
Summary
Back pain affects eight out of ten adults during their lifetime. It a huge economic burden on society, estimated to cost as much as 1-2% of gross national product in several European countries. Treatments for back pain have lower levels of success and are not as technologically mature as those for other musculoskeletal disorders such as hip and knee replacement. This application proposes to tackle one of the major barriers to the development of better surgical treatments for back pain.
At present, new spinal devices are commonly assessed in isolation in the laboratory under standardised conditions that do not represent the variation across the patient population. Consequently many interventions have failed during clinical trials or have proved to have poor long term success rates.
Using a combination of computational and experimental models, a new testing methodology will be developed that will enable the variation between patients to be simulated for the first time. This will enable spinal implants and therapies to be more robustly evaluated across a virtual patient population prior to clinical trial. The tools developed will be used in collaboration with clinicians and basic scientists to develop and, crucially, optimise new treatments that reduce back pain whilst preserving the unique functions of the spine.
If successful, this approach could be translated to evaluate and optimise emerging minimally invasive treatments in other joints such as the hip and knee. Research in the spine could then, for the first time, lead rather than follow that undertaken in other branches of orthopaedics.
Max ERC Funding
1 498 777 €
Duration
Start date: 2012-12-01, End date: 2018-11-30
Project acronym BCOOL
Project Barocaloric materials for energy-efficient solid-state cooling
Researcher (PI) Javier Eduardo Moya Raposo
Host Institution (HI) THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Call Details Starting Grant (StG), PE8, ERC-2015-STG
Summary Cooling is essential for food and drinks, medicine, electronics and thermal comfort. Thermal changes due to pressure-driven phase transitions in fluids have long been used in vapour compression systems to achieve continuous refrigeration and air conditioning, but their energy efficiency is relatively low, and the working fluids that are employed harm the environment when released to the atmosphere. More recently, the discovery of large thermal changes due to pressure-driven phase transitions in magnetic solids has led to suggestions for environmentally friendly solid-state cooling applications. However, for this new cooling technology to succeed, it is still necessary to find suitable barocaloric (BC) materials that satisfy the demanding requirements set by applications, namely very large thermal changes in inexpensive materials that occur near room temperature in response to small applied pressures.
I aim to develop new BC materials by exploiting phase transitions in non-magnetic solids whose structural and thermal properties are strongly coupled, namely ferroelectric salts, molecular crystals and hybrid materials. These materials are normally made from cheap abundant elements, and display very large latent heats and volume changes at structural phase transitions, which make them ideal candidates to exhibit extremely large BC effects that outperform those observed in state-of-the-art BC magnetic materials, and that match applications.
My unique approach combines: i) materials science to identify materials with outstanding BC performance, ii) advanced experimental techniques to explore and exploit these novel materials, iii) materials engineering to create new composite materials with enhanced BC properties, and iv) fabrication of BC devices, using insight gained from modelling of materials and device parameters. If successful, my ambitious strategy will culminate in revolutionary solid-state cooling devices that are environmentally friendly and energy efficient.
Summary
Cooling is essential for food and drinks, medicine, electronics and thermal comfort. Thermal changes due to pressure-driven phase transitions in fluids have long been used in vapour compression systems to achieve continuous refrigeration and air conditioning, but their energy efficiency is relatively low, and the working fluids that are employed harm the environment when released to the atmosphere. More recently, the discovery of large thermal changes due to pressure-driven phase transitions in magnetic solids has led to suggestions for environmentally friendly solid-state cooling applications. However, for this new cooling technology to succeed, it is still necessary to find suitable barocaloric (BC) materials that satisfy the demanding requirements set by applications, namely very large thermal changes in inexpensive materials that occur near room temperature in response to small applied pressures.
I aim to develop new BC materials by exploiting phase transitions in non-magnetic solids whose structural and thermal properties are strongly coupled, namely ferroelectric salts, molecular crystals and hybrid materials. These materials are normally made from cheap abundant elements, and display very large latent heats and volume changes at structural phase transitions, which make them ideal candidates to exhibit extremely large BC effects that outperform those observed in state-of-the-art BC magnetic materials, and that match applications.
My unique approach combines: i) materials science to identify materials with outstanding BC performance, ii) advanced experimental techniques to explore and exploit these novel materials, iii) materials engineering to create new composite materials with enhanced BC properties, and iv) fabrication of BC devices, using insight gained from modelling of materials and device parameters. If successful, my ambitious strategy will culminate in revolutionary solid-state cooling devices that are environmentally friendly and energy efficient.
Max ERC Funding
1 467 521 €
Duration
Start date: 2016-04-01, End date: 2021-03-31
Project acronym BIAF
Project Bird Inspired Autonomous Flight
Researcher (PI) Shane Paul Windsor
Host Institution (HI) UNIVERSITY OF BRISTOL
Call Details Starting Grant (StG), PE8, ERC-2015-STG
Summary The agile and efficient flight of birds shows what flight performance is physically possible, and in theory could be achieved by unmanned air vehicles (UAVs) of the same size. The overall aim of this project is to enhance the performance of small scale UAVs by developing novel technologies inspired by understanding how birds are adapted to interact with airflows. Small UAVs have the potential to dramatically change current practices in many areas such as, search and rescue, surveillance, and environmental monitoring. Currently the utility of these systems is limited by their operational endurance and their inability to operate in strong turbulent winds, especially those that often occur in urban environments. Birds are adapted to be able to fly in these conditions and actually use them to their advantage to minimise their energy output.
This project is composed of three tracks which contain elements of technology development, as well as scientific investigation looking at bird flight behaviour and aerodynamics. The first track looks at developing path planning algorithms for UAVs in urban environments based on how birds fly in these areas, by using GPS tracking and computational fluid dynamics alongside trajectory optimization. The second track aims to develop artificial wings with improved gust tolerance inspired by the features of feathered wings. Here, high speed video measurements of birds flying through gusts will be used alongside wind tunnel testing of artificial wings to discover what features of a bird’s wing help to alleviate gusts. The third track develops novel force and flow sensor arrays for autonomous flight control based on the sensor arrays found in flying animals. These arrays will be used to make UAVs with increased agility and robustness. This unique bird inspired approach uses biology to show what is possible, and engineering to find the features that enable this performance and develop them into functional technologies.
Summary
The agile and efficient flight of birds shows what flight performance is physically possible, and in theory could be achieved by unmanned air vehicles (UAVs) of the same size. The overall aim of this project is to enhance the performance of small scale UAVs by developing novel technologies inspired by understanding how birds are adapted to interact with airflows. Small UAVs have the potential to dramatically change current practices in many areas such as, search and rescue, surveillance, and environmental monitoring. Currently the utility of these systems is limited by their operational endurance and their inability to operate in strong turbulent winds, especially those that often occur in urban environments. Birds are adapted to be able to fly in these conditions and actually use them to their advantage to minimise their energy output.
This project is composed of three tracks which contain elements of technology development, as well as scientific investigation looking at bird flight behaviour and aerodynamics. The first track looks at developing path planning algorithms for UAVs in urban environments based on how birds fly in these areas, by using GPS tracking and computational fluid dynamics alongside trajectory optimization. The second track aims to develop artificial wings with improved gust tolerance inspired by the features of feathered wings. Here, high speed video measurements of birds flying through gusts will be used alongside wind tunnel testing of artificial wings to discover what features of a bird’s wing help to alleviate gusts. The third track develops novel force and flow sensor arrays for autonomous flight control based on the sensor arrays found in flying animals. These arrays will be used to make UAVs with increased agility and robustness. This unique bird inspired approach uses biology to show what is possible, and engineering to find the features that enable this performance and develop them into functional technologies.
Max ERC Funding
1 998 546 €
Duration
Start date: 2016-04-01, End date: 2021-03-31
Project acronym BioBlood
Project Development of a Bio-Inspired Blood Factory for Personalised Healthcare
Researcher (PI) Athanasios Mantalaris
Host Institution (HI) IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Call Details Advanced Grant (AdG), PE8, ERC-2013-ADG
Summary Personalized medicine is a medical model that proposes the customization of healthcare, with decisions and practices being tailored to the individual patient by use of patient-specific information and/or application of patient-specific cell-based therapies. BioBlood aims to deliver personalised healthcare through a “step change” in the clinical field of haemato-oncology. BioBlood represents an engineered bio-inspired integrated experimental/modelling platform for normal and abnormal haematopoiesis that receives disease & patient input (patient primary cells & patient/disease-specific data) and will produce cellular (red blood cell product) and drug (optimal drug treatment) therapies as its output. Blood supply to meet demand is the primary challenge for Blood Banks and requires significant resources to avoid shortages and ensure safety. An alternative, practical and cost-effective solution to conventional donated blood is essential to reduce patient morbidity and mortality, stabilise and guarantee the donor supply, limit multiple donor exposures, reduce risk of infection of known or as yet unidentified pathogens, and ensure a robust and safe turn-around for blood supply management. BioBlood aims to meet this challenge by developing a novel in vitro platform for the mass production of RBCs for clinical use. More than £32b/year is spent to develop and bring new drugs to market, which takes 14 years. Most patients diagnosed with leukaemias are unable to tolerate treatment and would benefit from novel agents. There is a need to optimise current treatment schedules for cancers such as AML to limit toxicities and improve clinical trial pathways for new drugs to enable personalised healthcare. BioBlood’s in vitro & in silico platform would be a powerful tool to tailor treatments in a patient- and leukaemia-specific chemotherapy schedule by considering the level of toxicity to the specific individual and treatment efficiency for the specific leukaemia a priori.
Summary
Personalized medicine is a medical model that proposes the customization of healthcare, with decisions and practices being tailored to the individual patient by use of patient-specific information and/or application of patient-specific cell-based therapies. BioBlood aims to deliver personalised healthcare through a “step change” in the clinical field of haemato-oncology. BioBlood represents an engineered bio-inspired integrated experimental/modelling platform for normal and abnormal haematopoiesis that receives disease & patient input (patient primary cells & patient/disease-specific data) and will produce cellular (red blood cell product) and drug (optimal drug treatment) therapies as its output. Blood supply to meet demand is the primary challenge for Blood Banks and requires significant resources to avoid shortages and ensure safety. An alternative, practical and cost-effective solution to conventional donated blood is essential to reduce patient morbidity and mortality, stabilise and guarantee the donor supply, limit multiple donor exposures, reduce risk of infection of known or as yet unidentified pathogens, and ensure a robust and safe turn-around for blood supply management. BioBlood aims to meet this challenge by developing a novel in vitro platform for the mass production of RBCs for clinical use. More than £32b/year is spent to develop and bring new drugs to market, which takes 14 years. Most patients diagnosed with leukaemias are unable to tolerate treatment and would benefit from novel agents. There is a need to optimise current treatment schedules for cancers such as AML to limit toxicities and improve clinical trial pathways for new drugs to enable personalised healthcare. BioBlood’s in vitro & in silico platform would be a powerful tool to tailor treatments in a patient- and leukaemia-specific chemotherapy schedule by considering the level of toxicity to the specific individual and treatment efficiency for the specific leukaemia a priori.
Max ERC Funding
2 498 903 €
Duration
Start date: 2014-01-01, End date: 2018-12-31
Project acronym BIOELE
Project Functional Biointerface Elements via Biomicrofabrication
Researcher (PI) YANYAN HUANG
Host Institution (HI) THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Call Details Starting Grant (StG), PE8, ERC-2017-STG
Summary Imagine in the future, bionic devices that can merge device and biology which can perform molecular sensing, simulate the functions of grown-organs in the lab, or even replace or improve parts of the organ as smart implants? Such bionic devices is set to transform a number of emerging fields, including synthetic biotechnology, regenerative medicine, and human-machine interfaces. Merging biology and man-made devices also mean that materials of vastly different properties need to be seamlessly integrated. One of the promising strategies to manufacture these devices is through 3D printing, which can structure different materials into functional devices, and simultaneously intertwining with biological matters. However, the requirement for biocompatibility, miniaturisation, portability and high performance in bionic devices pushes the current limit for micro- nanoscale 3D printing.
This proposal aims to develop a new multi-material, cross-length scale biofabrication platform, with specific focus in making future smart bionic devices. In particular, a new mechanism is proposed to smoothly interface diverse classes of materials, such that an active device component can be ‘shrunk’ into a single small fibre. This mechanism utilises the polymeric materials’ flow property under applied tensile forces, and their abilities to combine with other classes of materials, such as semi-conductors and metals to impart further functionalities. This smart device fibre can be custom-made to perform different tasks, such as light emission or energy harvesting, to bridge 3D bioprinting for the future creation of high performance, compact, and cell-friendly bionic and medical devices.
Summary
Imagine in the future, bionic devices that can merge device and biology which can perform molecular sensing, simulate the functions of grown-organs in the lab, or even replace or improve parts of the organ as smart implants? Such bionic devices is set to transform a number of emerging fields, including synthetic biotechnology, regenerative medicine, and human-machine interfaces. Merging biology and man-made devices also mean that materials of vastly different properties need to be seamlessly integrated. One of the promising strategies to manufacture these devices is through 3D printing, which can structure different materials into functional devices, and simultaneously intertwining with biological matters. However, the requirement for biocompatibility, miniaturisation, portability and high performance in bionic devices pushes the current limit for micro- nanoscale 3D printing.
This proposal aims to develop a new multi-material, cross-length scale biofabrication platform, with specific focus in making future smart bionic devices. In particular, a new mechanism is proposed to smoothly interface diverse classes of materials, such that an active device component can be ‘shrunk’ into a single small fibre. This mechanism utilises the polymeric materials’ flow property under applied tensile forces, and their abilities to combine with other classes of materials, such as semi-conductors and metals to impart further functionalities. This smart device fibre can be custom-made to perform different tasks, such as light emission or energy harvesting, to bridge 3D bioprinting for the future creation of high performance, compact, and cell-friendly bionic and medical devices.
Max ERC Funding
1 486 938 €
Duration
Start date: 2018-01-01, End date: 2022-12-31
Project acronym BlackHoleMaps
Project Mapping gravitational waves from collisions of black holes
Researcher (PI) Mark Douglas Hannam
Host Institution (HI) CARDIFF UNIVERSITY
Call Details Consolidator Grant (CoG), PE2, ERC-2014-CoG
Summary Breakthroughs in numerical relativity in 2005 gave us unprecedented access to the strong-field regime of general relativity, making possible solutions of the full nonlinear Einstein equations for the merger of two black holes. Numerical relativity is also crucial to study fundamental physics with gravitational-wave (GW) observations: numerical solutions allow us to construct models that will be essential to extract physical information from observations in data from Advanced LIGO and Virgo, which will operate from late 2015. Complete signal models will allow us to follow up our first theoretical predictions of the nature of black-hole mergers with their first observational measurements.
The goal of this project is to advance numerical-relativity methods, deepen our understanding of black-hole mergers, and map the parameter space of binary configurations with the most comprehensive and systematic set of numerical calculations performed to date, in order to produce a complete GW signal model. Central to this problem is the purely general-relativistic effect of orbital precession. The inclusion of precession in waveform models is the most challenging and urgent theoretical problem in the build-up to GW astronomy. Simulations must cover a seven-dimensional parameter space of binary configurations, but their computational cost makes a naive covering unfeasible. This project capitalizes on a breakthrough preliminary model produced by my team in 2013, with the pragmatic goal of focussing on the physics that will be measurable with GW detectors over the next five years.
My team at Cardiff is uniquely placed to tackle this problem. Since 2005 I have been at the forefront of black-hole simulations and waveform modelling, and the Cardiff group is a world leader in analysis of GW detector data. This project will consolidate my team to make breakthroughs in strong-field gravity, astrophysics, fundamental physics and cosmology using GW observations.
Summary
Breakthroughs in numerical relativity in 2005 gave us unprecedented access to the strong-field regime of general relativity, making possible solutions of the full nonlinear Einstein equations for the merger of two black holes. Numerical relativity is also crucial to study fundamental physics with gravitational-wave (GW) observations: numerical solutions allow us to construct models that will be essential to extract physical information from observations in data from Advanced LIGO and Virgo, which will operate from late 2015. Complete signal models will allow us to follow up our first theoretical predictions of the nature of black-hole mergers with their first observational measurements.
The goal of this project is to advance numerical-relativity methods, deepen our understanding of black-hole mergers, and map the parameter space of binary configurations with the most comprehensive and systematic set of numerical calculations performed to date, in order to produce a complete GW signal model. Central to this problem is the purely general-relativistic effect of orbital precession. The inclusion of precession in waveform models is the most challenging and urgent theoretical problem in the build-up to GW astronomy. Simulations must cover a seven-dimensional parameter space of binary configurations, but their computational cost makes a naive covering unfeasible. This project capitalizes on a breakthrough preliminary model produced by my team in 2013, with the pragmatic goal of focussing on the physics that will be measurable with GW detectors over the next five years.
My team at Cardiff is uniquely placed to tackle this problem. Since 2005 I have been at the forefront of black-hole simulations and waveform modelling, and the Cardiff group is a world leader in analysis of GW detector data. This project will consolidate my team to make breakthroughs in strong-field gravity, astrophysics, fundamental physics and cosmology using GW observations.
Max ERC Funding
1 998 009 €
Duration
Start date: 2015-10-01, End date: 2020-09-30
Project acronym BRIDGE
Project Biomimetic process design for tissue regeneration:
from bench to bedside via in silico modelling
Researcher (PI) Liesbet Geris
Host Institution (HI) UNIVERSITE DE LIEGE
Call Details Starting Grant (StG), PE8, ERC-2011-StG_20101014
Summary "Tissue engineering (TE), the interdisciplinary field combining biomedical and engineering sciences in the search for functional man-made organ replacements, has key issues with the quantity and quality of the generated products. Protocols followed in the lab are mainly trial and error based, requiring a huge amount of manual interventions and lacking clear early time-point quality criteria to guide the process. As a result, these processes are very hard to scale up to industrial production levels. BRIDGE aims to fortify the engineering aspects of the TE field by adding a higher level of understanding and control to the manufacturing process (MP) through the use of in silico models. BRIDGE will focus on the bone TE field to provide proof of concept for its in silico approach.
The combination of the applicant's well-received published and ongoing work on a wide range of modelling tools in the bone field combined with the state-of-the-art experimental techniques present in the TE lab of the additional participant allows envisaging following innovation and impact:
1. proof-of-concept of the use of an in silico blue-print for the design and control of a robust modular TE MP;
2. model-derived optimised culture conditions for patient derived cell populations increasing modular robustness of in vitro chondrogenesis/endochondral ossification;
3. in silico identification of a limited set of in vitro biomarkers that is predictive of the in vivo outcome;
4. model-derived optimised culture conditions increasing quantity and quality of the in vivo outcome of the TE MP;
5. incorporation of congenital defects in the in silico MP design, constituting a further validation of BRIDGE’s in silico approach and a necessary step towards personalised medical care.
We believe that the systematic – and unprecedented – integration of (bone) TE and mathematical modelling, as proposed in BRIDGE, is required to come to a rationalized, engineering approach to design and control bone TE MPs."
Summary
"Tissue engineering (TE), the interdisciplinary field combining biomedical and engineering sciences in the search for functional man-made organ replacements, has key issues with the quantity and quality of the generated products. Protocols followed in the lab are mainly trial and error based, requiring a huge amount of manual interventions and lacking clear early time-point quality criteria to guide the process. As a result, these processes are very hard to scale up to industrial production levels. BRIDGE aims to fortify the engineering aspects of the TE field by adding a higher level of understanding and control to the manufacturing process (MP) through the use of in silico models. BRIDGE will focus on the bone TE field to provide proof of concept for its in silico approach.
The combination of the applicant's well-received published and ongoing work on a wide range of modelling tools in the bone field combined with the state-of-the-art experimental techniques present in the TE lab of the additional participant allows envisaging following innovation and impact:
1. proof-of-concept of the use of an in silico blue-print for the design and control of a robust modular TE MP;
2. model-derived optimised culture conditions for patient derived cell populations increasing modular robustness of in vitro chondrogenesis/endochondral ossification;
3. in silico identification of a limited set of in vitro biomarkers that is predictive of the in vivo outcome;
4. model-derived optimised culture conditions increasing quantity and quality of the in vivo outcome of the TE MP;
5. incorporation of congenital defects in the in silico MP design, constituting a further validation of BRIDGE’s in silico approach and a necessary step towards personalised medical care.
We believe that the systematic – and unprecedented – integration of (bone) TE and mathematical modelling, as proposed in BRIDGE, is required to come to a rationalized, engineering approach to design and control bone TE MPs."
Max ERC Funding
1 191 440 €
Duration
Start date: 2011-12-01, End date: 2016-11-30
Project acronym BSMWLHCB
Project Advanced techniques to Search for Physics Beyond the Standard Model with the LHCb Detector at CERN
Researcher (PI) Timothy John Gershon
Host Institution (HI) THE UNIVERSITY OF WARWICK
Call Details Starting Grant (StG), PE2, ERC-2009-StG
Summary I propose a programme of precision tests of the Standard Model of particle physics to be carried out using the LHCb experiment at CERN. The proposal is focussed on studies of CP violation - differences between the behaviour of particles and antiparticles that are fundamental to understanding why the Universe we see today is made up of matter, not antimatter. The innovative feature of this research is the use of Dalitz plot analyses to improve the sensitivity to interesting CP violation effects. Recently I have developed a number of new methods to search for CP violation based on this technique. These methods can be used at LHCb and will extend the physics reach of the experiment beyond what was previously considered possible. I propose to create a small research team, based at the University of Warwick, to develop these methods and to make a number of precise measurements of CP violation parameters using the LHCb experiment. By comparing the results with the Standard Model predictions for these parameters, effects due to non-standard particles can be observed or highly constrained. The results of this work have the potential to redefine the direction of this research field. They will be essential to develop theories of particle physics that go beyond the Standard Model and attempt to address great unanswered questions, such as the origin of the matter--antimatter asymmetry of the Universe.
Summary
I propose a programme of precision tests of the Standard Model of particle physics to be carried out using the LHCb experiment at CERN. The proposal is focussed on studies of CP violation - differences between the behaviour of particles and antiparticles that are fundamental to understanding why the Universe we see today is made up of matter, not antimatter. The innovative feature of this research is the use of Dalitz plot analyses to improve the sensitivity to interesting CP violation effects. Recently I have developed a number of new methods to search for CP violation based on this technique. These methods can be used at LHCb and will extend the physics reach of the experiment beyond what was previously considered possible. I propose to create a small research team, based at the University of Warwick, to develop these methods and to make a number of precise measurements of CP violation parameters using the LHCb experiment. By comparing the results with the Standard Model predictions for these parameters, effects due to non-standard particles can be observed or highly constrained. The results of this work have the potential to redefine the direction of this research field. They will be essential to develop theories of particle physics that go beyond the Standard Model and attempt to address great unanswered questions, such as the origin of the matter--antimatter asymmetry of the Universe.
Max ERC Funding
1 682 800 €
Duration
Start date: 2010-02-01, End date: 2016-01-31
Project acronym CABUM
Project An investigation of the mechanisms at the interaction between cavitation bubbles and contaminants
Researcher (PI) Matevz DULAR
Host Institution (HI) UNIVERZA V LJUBLJANI
Call Details Consolidator Grant (CoG), PE8, ERC-2017-COG
Summary A sudden decrease in pressure triggers the formation of vapour and gas bubbles inside a liquid medium (also called cavitation). This leads to many (key) engineering problems: material loss, noise and vibration of hydraulic machinery. On the other hand, cavitation is a potentially a useful phenomenon: the extreme conditions are increasingly used for a wide variety of applications such as surface cleaning, enhanced chemistry, and waste water treatment (bacteria eradication and virus inactivation).
Despite this significant progress a large gap persists between the understanding of the mechanisms that contribute to the effects of cavitation and its application. Although engineers are already commercializing devices that employ cavitation, we are still not able to answer the fundamental question: What precisely are the mechanisms how bubbles can clean, disinfect, kill bacteria and enhance chemical activity? The overall objective of the project is to understand and determine the fundamental physics of the interaction of cavitation bubbles with different contaminants. To address this issue, the CABUM project will investigate the physical background of cavitation from physical, biological and engineering perspective on three complexity scales: i) on single bubble level, ii) on organised and iii) on random bubble clusters, producing a progressive multidisciplinary synergetic effect.
The proposed synergetic approach builds on the PI's preliminary research and employs novel experimental and numerical methodologies, some of which have been developed by the PI and his research group, to explore the physics of cavitation behaviour in interaction with bacteria and viruses.
Understanding the fundamental physical background of cavitation in interaction with contaminants will have a ground-breaking implications in various scientific fields (engineering, chemistry and biology) and will, in the future, enable the exploitation of cavitation in water and soil treatment processes.
Summary
A sudden decrease in pressure triggers the formation of vapour and gas bubbles inside a liquid medium (also called cavitation). This leads to many (key) engineering problems: material loss, noise and vibration of hydraulic machinery. On the other hand, cavitation is a potentially a useful phenomenon: the extreme conditions are increasingly used for a wide variety of applications such as surface cleaning, enhanced chemistry, and waste water treatment (bacteria eradication and virus inactivation).
Despite this significant progress a large gap persists between the understanding of the mechanisms that contribute to the effects of cavitation and its application. Although engineers are already commercializing devices that employ cavitation, we are still not able to answer the fundamental question: What precisely are the mechanisms how bubbles can clean, disinfect, kill bacteria and enhance chemical activity? The overall objective of the project is to understand and determine the fundamental physics of the interaction of cavitation bubbles with different contaminants. To address this issue, the CABUM project will investigate the physical background of cavitation from physical, biological and engineering perspective on three complexity scales: i) on single bubble level, ii) on organised and iii) on random bubble clusters, producing a progressive multidisciplinary synergetic effect.
The proposed synergetic approach builds on the PI's preliminary research and employs novel experimental and numerical methodologies, some of which have been developed by the PI and his research group, to explore the physics of cavitation behaviour in interaction with bacteria and viruses.
Understanding the fundamental physical background of cavitation in interaction with contaminants will have a ground-breaking implications in various scientific fields (engineering, chemistry and biology) and will, in the future, enable the exploitation of cavitation in water and soil treatment processes.
Max ERC Funding
1 904 565 €
Duration
Start date: 2018-07-01, End date: 2023-06-30
Project acronym CAD4FACE
Project Computational modelling for personalised treatment of congenital craniofacial abnormalities
Researcher (PI) Silvia SCHIEVANO
Host Institution (HI) UNIVERSITY COLLEGE LONDON
Call Details Starting Grant (StG), PE8, ERC-2017-STG
Summary Craniosynostosis is a group of congenital craniofacial abnormalities consisting in premature fusion (ossification) of one or more cranial sutures during infancy. This results in growth restriction perpendicular to the axis of the suture and promotes growth parallel to it, causing physical deformation of the cranial and facial skeleton, as well as distortion of the underling brain, with potential detrimental effects on its function: visual loss, sleep apnoea, feeding and breathing difficulties, and neurodevelopment delay. Conventional management of craniosynostosis involves craniofacial surgery delivered by excision of the prematurely fused sutures, multiple bone cuts and remodelling of the skull deformities, with the primary goal of improving patient function, while normalising their appearance. Cranial vault remodelling surgical procedures, aided by internal and external devices, have proven functionally and aesthetically effective in correcting skull deformities, but final results remain unpredictable and often suboptimal because of an incomplete understanding of the biomechanical interaction between the device and the skull.
The overall aim of this grant is to create a validated and robust computational framework that integrates patient information and device design to deliver personalised care in paediatric craniofacial surgery in order to improve clinical outcomes. A virtual model of the infant skull with craniosynostosis, including viscoelastic properties and mechano-biology regulation, will be developed to simulate device implantation and performance over time, and will be validated using clinical data from patient populations treated with current devices. Bespoke new devices will be designed allowing for pre-programmed 3D shapes to be delivered with continuous force during the implantation period. Patient specific skull models will be used to virtually test and optimise the personalised devices, and to tailor the surgical approach for each individual case.
Summary
Craniosynostosis is a group of congenital craniofacial abnormalities consisting in premature fusion (ossification) of one or more cranial sutures during infancy. This results in growth restriction perpendicular to the axis of the suture and promotes growth parallel to it, causing physical deformation of the cranial and facial skeleton, as well as distortion of the underling brain, with potential detrimental effects on its function: visual loss, sleep apnoea, feeding and breathing difficulties, and neurodevelopment delay. Conventional management of craniosynostosis involves craniofacial surgery delivered by excision of the prematurely fused sutures, multiple bone cuts and remodelling of the skull deformities, with the primary goal of improving patient function, while normalising their appearance. Cranial vault remodelling surgical procedures, aided by internal and external devices, have proven functionally and aesthetically effective in correcting skull deformities, but final results remain unpredictable and often suboptimal because of an incomplete understanding of the biomechanical interaction between the device and the skull.
The overall aim of this grant is to create a validated and robust computational framework that integrates patient information and device design to deliver personalised care in paediatric craniofacial surgery in order to improve clinical outcomes. A virtual model of the infant skull with craniosynostosis, including viscoelastic properties and mechano-biology regulation, will be developed to simulate device implantation and performance over time, and will be validated using clinical data from patient populations treated with current devices. Bespoke new devices will be designed allowing for pre-programmed 3D shapes to be delivered with continuous force during the implantation period. Patient specific skull models will be used to virtually test and optimise the personalised devices, and to tailor the surgical approach for each individual case.
Max ERC Funding
1 498 772 €
Duration
Start date: 2018-03-01, End date: 2023-02-28
Project acronym CAPaCITy
Project Designing Conjugated Polymers for Photocatalysis and Ion Transport
Researcher (PI) Jenny NELSON
Host Institution (HI) IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Call Details Advanced Grant (AdG), PE8, ERC-2016-ADG
Summary Solar energy conversion will play an essential role in the future supply of clean energy. Secure access to energy sources will require energy conversion technologies that are low impact, distributed and accessible both technically and financially. Molecular electronic materials embody these possibilities, offering facile synthesis, low energy production and the versatility to allow performance to be maximized for specific applications. Moreover, they bring appealing similarities with nature’s intrinsically low impact energy conversion materials. Whilst molecular semiconductors have been studied in detail for solar-to-electric energy conversion they have seldom been studied for solar-to-chemical conversion or for charge storage. However, they bring exciting potential advantages in terms of their light harvesting properties, the range of microstructures possible and the ability to tune their electrical properties. Polymer materials applied to solar chemical generation could open up an innovative route to artificial fuels, with the option to control light harvesting and charge separation through structural control. Polymer materials applied to mixed (electronic / ionic) conduction provide a route to lower cost electrochemical storage, as well as to biocompatible devices and sensors. Stimulated by recent experimental breakthroughs in the application of polymers as photocatalysts and ion transport media I will exploit my expertise in multi-scale modelling and functional characterization of molecular electronic materials and devices to develop a design framework for energy conversion and storage in conjugated polymer materials. This proposal aims to disentangle the parameters that govern the performance of conjugated polymer based photocatalysts and ion transport media to discover the underlying functional mechanisms. The tools generated will serve to enable the design and development of high performance materials for energy conversion devices.
Summary
Solar energy conversion will play an essential role in the future supply of clean energy. Secure access to energy sources will require energy conversion technologies that are low impact, distributed and accessible both technically and financially. Molecular electronic materials embody these possibilities, offering facile synthesis, low energy production and the versatility to allow performance to be maximized for specific applications. Moreover, they bring appealing similarities with nature’s intrinsically low impact energy conversion materials. Whilst molecular semiconductors have been studied in detail for solar-to-electric energy conversion they have seldom been studied for solar-to-chemical conversion or for charge storage. However, they bring exciting potential advantages in terms of their light harvesting properties, the range of microstructures possible and the ability to tune their electrical properties. Polymer materials applied to solar chemical generation could open up an innovative route to artificial fuels, with the option to control light harvesting and charge separation through structural control. Polymer materials applied to mixed (electronic / ionic) conduction provide a route to lower cost electrochemical storage, as well as to biocompatible devices and sensors. Stimulated by recent experimental breakthroughs in the application of polymers as photocatalysts and ion transport media I will exploit my expertise in multi-scale modelling and functional characterization of molecular electronic materials and devices to develop a design framework for energy conversion and storage in conjugated polymer materials. This proposal aims to disentangle the parameters that govern the performance of conjugated polymer based photocatalysts and ion transport media to discover the underlying functional mechanisms. The tools generated will serve to enable the design and development of high performance materials for energy conversion devices.
Max ERC Funding
2 351 550 €
Duration
Start date: 2017-10-01, End date: 2022-09-30
Project acronym CAPS
Project Capillary suspensions: a novel route for versatile, cost efficient and environmentally friendly material design
Researcher (PI) Erin Crystal Koos
Host Institution (HI) KATHOLIEKE UNIVERSITEIT LEUVEN
Call Details Starting Grant (StG), PE8, ERC-2013-StG
Summary A wide variety of materials including coatings and adhesives, emerging materials for nanotechnology products, as well as everyday food products are processed or delivered as suspensions. The flow properties of such suspensions must be finely adjusted according to the demands of the respective processing techniques, even for the feel of cosmetics and the perception of food products is highly influenced by their rheological properties. The recently developed capillary suspensions concept has the potential to revolutionize product formulations and material design. When a small amount (less than 1%) of a second immiscible liquid is added to the continuous phase of a suspension, the rheological properties of the mixture are dramatically altered from a fluid-like to a gel-like state or from a weak to a strong gel and the strength can be tuned in a wide range covering orders of magnitude. Capillary suspensions can be used to create smart, tunable fluids, stabilize mixtures that would otherwise phase separate, significantly reduce the amount organic or polymeric additives, and the strong particle network can be used as a precursor for the manufacturing of cost-efficient porous ceramics and foams with unprecedented properties.
This project will investigate the influence of factors determining capillary suspension formation, the strength of these admixtures as a function of these aspects, and how capillary suspensions depend on external forces. Only such a fundamental understanding of the network formation in capillary suspensions on both the micro- and macroscopic scale will allow for the design of sophisticated new materials. The main objectives of this proposal are to quantify and predict the strength of these admixtures and then use this information to design a variety of new materials in very different application areas including, e.g., porous materials, water-based coatings, ultra low fat foods, and conductive films.
Summary
A wide variety of materials including coatings and adhesives, emerging materials for nanotechnology products, as well as everyday food products are processed or delivered as suspensions. The flow properties of such suspensions must be finely adjusted according to the demands of the respective processing techniques, even for the feel of cosmetics and the perception of food products is highly influenced by their rheological properties. The recently developed capillary suspensions concept has the potential to revolutionize product formulations and material design. When a small amount (less than 1%) of a second immiscible liquid is added to the continuous phase of a suspension, the rheological properties of the mixture are dramatically altered from a fluid-like to a gel-like state or from a weak to a strong gel and the strength can be tuned in a wide range covering orders of magnitude. Capillary suspensions can be used to create smart, tunable fluids, stabilize mixtures that would otherwise phase separate, significantly reduce the amount organic or polymeric additives, and the strong particle network can be used as a precursor for the manufacturing of cost-efficient porous ceramics and foams with unprecedented properties.
This project will investigate the influence of factors determining capillary suspension formation, the strength of these admixtures as a function of these aspects, and how capillary suspensions depend on external forces. Only such a fundamental understanding of the network formation in capillary suspensions on both the micro- and macroscopic scale will allow for the design of sophisticated new materials. The main objectives of this proposal are to quantify and predict the strength of these admixtures and then use this information to design a variety of new materials in very different application areas including, e.g., porous materials, water-based coatings, ultra low fat foods, and conductive films.
Max ERC Funding
1 489 618 €
Duration
Start date: 2013-08-01, End date: 2018-07-31
Project acronym CGR2011TPS
Project Challenging General Relativity
Researcher (PI) Thomas Sotiriou
Host Institution (HI) THE UNIVERSITY OF NOTTINGHAM
Call Details Starting Grant (StG), PE2, ERC-2012-StG_20111012
Summary General relativity, Einstein's celebrated theory, has been very successful as a theory of the gravitational interaction. However, within the course of the last decades several issues have been pointed out as indicating its limitations: the inevitable existence of spacetime singularities and the fact that it is not a renormalizable theory manifest as shortcomings at very small scales. The inability of the theory to explain the late time accelerated expansion of the universe or the rotational curves of galaxies without the need of unobserved, mysterious forms of matter/energy can be interpreted as shortcomings at large scales. These riddles make gravity by far the most enigmatic of interactions nowadays. Therefore, the understanding of gravity beyond general relativity seems to be more pertinent than ever.
We propose to address this difficult issue by considering a synthetic approach towards the understand of the limitations of general relativity and the study of phenomenology which is usually considered to be outsides its realm. The proposed directions include, but are not limited to: the study of quantum gravity candidates and their phenomenology; extensions or modifications of general relativity which may address renormalizability issues or cosmological observations; explorations of fundamental principles of general relativity and the possible violation of such principles; the study of the implications of deviations from Einstein's theory for astrophysics and cosmology and the possible ways to constrain such deviations; and the study of effects within the framework of general relativity which lie at the limit of its validity as a gravity theory. The deeper understanding of each of these issues will provide an important piece to the puzzle. The synthesis of this pieces is most likely to significantly aid our understanding of gravity, and this is our ultimate goal.
Summary
General relativity, Einstein's celebrated theory, has been very successful as a theory of the gravitational interaction. However, within the course of the last decades several issues have been pointed out as indicating its limitations: the inevitable existence of spacetime singularities and the fact that it is not a renormalizable theory manifest as shortcomings at very small scales. The inability of the theory to explain the late time accelerated expansion of the universe or the rotational curves of galaxies without the need of unobserved, mysterious forms of matter/energy can be interpreted as shortcomings at large scales. These riddles make gravity by far the most enigmatic of interactions nowadays. Therefore, the understanding of gravity beyond general relativity seems to be more pertinent than ever.
We propose to address this difficult issue by considering a synthetic approach towards the understand of the limitations of general relativity and the study of phenomenology which is usually considered to be outsides its realm. The proposed directions include, but are not limited to: the study of quantum gravity candidates and their phenomenology; extensions or modifications of general relativity which may address renormalizability issues or cosmological observations; explorations of fundamental principles of general relativity and the possible violation of such principles; the study of the implications of deviations from Einstein's theory for astrophysics and cosmology and the possible ways to constrain such deviations; and the study of effects within the framework of general relativity which lie at the limit of its validity as a gravity theory. The deeper understanding of each of these issues will provide an important piece to the puzzle. The synthesis of this pieces is most likely to significantly aid our understanding of gravity, and this is our ultimate goal.
Max ERC Funding
1 375 226 €
Duration
Start date: 2012-08-01, End date: 2018-01-31
Project acronym CHAOS-PIQUANT
Project Universality and chaos in PT-symmetric quantum systems
Researcher (PI) Eva-Maria GRAEFE
Host Institution (HI) IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Call Details Starting Grant (StG), PE2, ERC-2017-STG
Summary The world of our daily experiences, described by classical physics, is built out of fundamental particles, governed by the laws of quantum mechanics. The striking difference between quantum and classical behaviour becomes most apparent in the realm of chaos, an extreme sensitivity to initial conditions, which is common in classical systems but impossible under quantum laws. The investigation of characteristic features of quantum systems whose classical counterparts are chaotic has illuminated foundational problems and led to a variety of technological applications. Traditional quantum theory focuses on the description of closed systems without losses. Every realistic system, however, contains unwanted losses and dissipation, but the idea to engineer them to generate desirable effects has recently come into the focus of scientific attention. The surprising properties of quantum systems with balanced gain and loss (PT-symmetric systems) have sparked much interest. The first experiments on PT-symmetry in optics have been identified as one of the top ten physics discoveries of the past decade in Nature Physics. New experimental areas are rapidly emerging. Our understanding of PT-symmetric quantum systems, however, is still limited. One major shortcoming is that the emergence of chaos and universality in these systems is hitherto nearly unexplored. I propose to investigate PT-symmetric quantum chaos to establish this new research area and overturn some common perceptions in the existing fields of PT-symmetry and quantum chaos. Ultimately this will lead to new experimental applications and quantum technologies. Building on recent conceptual breakthroughs I have made, I will a) identify spectral and dynamical features of chaos in PT-symmetric quantum systems, b) establish new universality classes, c) provide powerful semiclassical tools for the simulation of generic quantum systems, and d) facilitate experimental applications in microwave cavities and cold atoms.
Summary
The world of our daily experiences, described by classical physics, is built out of fundamental particles, governed by the laws of quantum mechanics. The striking difference between quantum and classical behaviour becomes most apparent in the realm of chaos, an extreme sensitivity to initial conditions, which is common in classical systems but impossible under quantum laws. The investigation of characteristic features of quantum systems whose classical counterparts are chaotic has illuminated foundational problems and led to a variety of technological applications. Traditional quantum theory focuses on the description of closed systems without losses. Every realistic system, however, contains unwanted losses and dissipation, but the idea to engineer them to generate desirable effects has recently come into the focus of scientific attention. The surprising properties of quantum systems with balanced gain and loss (PT-symmetric systems) have sparked much interest. The first experiments on PT-symmetry in optics have been identified as one of the top ten physics discoveries of the past decade in Nature Physics. New experimental areas are rapidly emerging. Our understanding of PT-symmetric quantum systems, however, is still limited. One major shortcoming is that the emergence of chaos and universality in these systems is hitherto nearly unexplored. I propose to investigate PT-symmetric quantum chaos to establish this new research area and overturn some common perceptions in the existing fields of PT-symmetry and quantum chaos. Ultimately this will lead to new experimental applications and quantum technologies. Building on recent conceptual breakthroughs I have made, I will a) identify spectral and dynamical features of chaos in PT-symmetric quantum systems, b) establish new universality classes, c) provide powerful semiclassical tools for the simulation of generic quantum systems, and d) facilitate experimental applications in microwave cavities and cold atoms.
Max ERC Funding
1 293 023 €
Duration
Start date: 2018-02-01, End date: 2023-01-31
Project acronym CHROMIUM
Project CHROMIUM
Researcher (PI) Jennifer THOMAS
Host Institution (HI) UNIVERSITY COLLEGE LONDON
Call Details Advanced Grant (AdG), PE2, ERC-2015-AdG
Summary Why the Universe is void of anti-matter is one of the remaining Big Questions in Science.One explanation is provided within the Standard Model by violation of Charge Parity (CP) symmetry, producing differences between the behavior of particles and their anti-particles.CP violation in the neutrino sector could allow a mechanism by which the matter-anti matter asymmetry arose.The objective of this proposal is to enable a step change in our sensitivity to CP violation in the neutrino sector. I have pioneered the concepts and led the deployment of a small prototype using a novel approach which could eventually lead to the construction of a revolutionary Mega-ton scale Water Cherenkov (WC) neutrino detector.The goal of my research program is to demonstrate the feasibility of this approach via the construction of an intermediate sized prototype with an expandable fiducial mass of up to 10-20kt. It will use a low-cost and lightweight structure, filled with purified water and submerged for mechanical strength and cosmic ray shielding in a 60m deep flooded mine pit in the path of Fermilab’s NuMI neutrino beam in N. Minnesota.The European contribution to this experiment will be profound and definitive.Applying the idea of fast timing and good position resolution of small photodetectors, already pioneered in Europe, in place of large-area photodetector, we will revolutionize WC design.The game-changing nature of this philosophy will be demonstrated via the proof of the detector construction and the observation of electron neutrino events form the NuMI beam.The successful completion of this R&D program will demonstrate a factor of up to 100 decrease in cost compared to conventional detectors and the proof that precision neutrino measurements could be made inside a few years rather than the presently needed decades.
The project describes a five year program of work amounting to a total funding request of €3.5M, including an extra €1M of equipment funds.
Summary
Why the Universe is void of anti-matter is one of the remaining Big Questions in Science.One explanation is provided within the Standard Model by violation of Charge Parity (CP) symmetry, producing differences between the behavior of particles and their anti-particles.CP violation in the neutrino sector could allow a mechanism by which the matter-anti matter asymmetry arose.The objective of this proposal is to enable a step change in our sensitivity to CP violation in the neutrino sector. I have pioneered the concepts and led the deployment of a small prototype using a novel approach which could eventually lead to the construction of a revolutionary Mega-ton scale Water Cherenkov (WC) neutrino detector.The goal of my research program is to demonstrate the feasibility of this approach via the construction of an intermediate sized prototype with an expandable fiducial mass of up to 10-20kt. It will use a low-cost and lightweight structure, filled with purified water and submerged for mechanical strength and cosmic ray shielding in a 60m deep flooded mine pit in the path of Fermilab’s NuMI neutrino beam in N. Minnesota.The European contribution to this experiment will be profound and definitive.Applying the idea of fast timing and good position resolution of small photodetectors, already pioneered in Europe, in place of large-area photodetector, we will revolutionize WC design.The game-changing nature of this philosophy will be demonstrated via the proof of the detector construction and the observation of electron neutrino events form the NuMI beam.The successful completion of this R&D program will demonstrate a factor of up to 100 decrease in cost compared to conventional detectors and the proof that precision neutrino measurements could be made inside a few years rather than the presently needed decades.
The project describes a five year program of work amounting to a total funding request of €3.5M, including an extra €1M of equipment funds.
Max ERC Funding
3 500 000 €
Duration
Start date: 2016-10-01, End date: 2021-09-30
Project acronym CIF
Project Complex Interfacial Flows: From the Nano- to the Macro-Scale
Researcher (PI) Serafim Kalliadasis
Host Institution (HI) IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Call Details Advanced Grant (AdG), PE8, ERC-2009-AdG
Summary A wide variety of natural phenomena and technological applications involve flow, transport and chemical reactions taking place on or near fluid-solid or fluid-fluid interfaces. From gravity currents under water and lava flows to heat and mass transport processes in engineering applications and to the rapidly developing field of microfluidics. Both equilibrium properties of a fluid and transportcoefficients are modified in the vicinity of interfaces. The effect of these changes is crucial in the behavior of ultra-thin fluidfilms and fluid motion in microchannels of micro-electromechanical systems, but is essential as well in macroscopic phenomena involving interfacial singularities, such as thin-film rupture and motion of three-phase contact lines associated e.g. with droplet spreading. Interface boundaries are mesoscopic structures. While material properties vary smoothly at macroscopic distances from an interface, gradients in the normal direction of conserved parameters, such as density, are steep with strong variations as the molecular scale in the neighborhood of the interface is approached. This brings about a contradiction between the need in macroscopic description and a necessity to take into consideration microscopic factors that come to influence the fluid motion and transport on incommensurately larger scales. The aim of the proposed research is to develop a class of novel continuous models bridging the gap between molecular dynamics and conventional hydrodynamics and applicable at mesoscopic distances from gas-liquid and fluid-solid interfaces. A combination of analytical techniques, numerical modeling and computer-aided multiscale analysis will be employed. The results of the proposed work will greatly contribute to the fundamental understanding of mesoscopic non-equilibrium phenomena in the vicinity of interfaces and to the development of novel computational methods combining the advantages of molecular and continuous models.
Summary
A wide variety of natural phenomena and technological applications involve flow, transport and chemical reactions taking place on or near fluid-solid or fluid-fluid interfaces. From gravity currents under water and lava flows to heat and mass transport processes in engineering applications and to the rapidly developing field of microfluidics. Both equilibrium properties of a fluid and transportcoefficients are modified in the vicinity of interfaces. The effect of these changes is crucial in the behavior of ultra-thin fluidfilms and fluid motion in microchannels of micro-electromechanical systems, but is essential as well in macroscopic phenomena involving interfacial singularities, such as thin-film rupture and motion of three-phase contact lines associated e.g. with droplet spreading. Interface boundaries are mesoscopic structures. While material properties vary smoothly at macroscopic distances from an interface, gradients in the normal direction of conserved parameters, such as density, are steep with strong variations as the molecular scale in the neighborhood of the interface is approached. This brings about a contradiction between the need in macroscopic description and a necessity to take into consideration microscopic factors that come to influence the fluid motion and transport on incommensurately larger scales. The aim of the proposed research is to develop a class of novel continuous models bridging the gap between molecular dynamics and conventional hydrodynamics and applicable at mesoscopic distances from gas-liquid and fluid-solid interfaces. A combination of analytical techniques, numerical modeling and computer-aided multiscale analysis will be employed. The results of the proposed work will greatly contribute to the fundamental understanding of mesoscopic non-equilibrium phenomena in the vicinity of interfaces and to the development of novel computational methods combining the advantages of molecular and continuous models.
Max ERC Funding
1 273 788 €
Duration
Start date: 2010-04-01, End date: 2016-03-31
Project acronym CO2LIFE
Project BIOMIMETIC FIXATION OF CO2 AS SOURCE OF SALTS AND GLUCOSE
Researcher (PI) Patricia LUIS ALCONERO
Host Institution (HI) UNIVERSITE CATHOLIQUE DE LOUVAIN
Call Details Starting Grant (StG), PE8, ERC-2017-STG
Summary The continued increase in the atmospheric concentration of CO2 due to anthropogenic emissions is leading to significant changes in climate, with the industry accounting for one-third of all the energy used globally and for almost 40% of worldwide CO2 emissions. Fast actions are required to decrease the concentration of this greenhouse gas in the atmosphere, value that has currently reaching 400 ppm. Among the technological possibilities that are on the table to reduce CO2 emissions, carbon capture and storage into geological deposits is one of the main strategies that is being applied. However, the final objective of this strategy is to remove CO2 without considering the enormous potential of this molecule as a source of carbon for the production of valuable compounds. Nature has developed an effective and equilibrated mechanism to concentrate CO2 and fixate the inorganic carbon into organic material (e.g., glucose) by means of enzymatic action. Mimicking Nature and take advantage of millions of years of evolution should be considered as a basic starting point in the development of smart and highly effective processes. In addition, the use of amino-acid salts for CO2 capture is envisaged as a potential approach to recover CO2 in the form of (bi)carbonates.
The project CO2LIFE presents the overall objective of developing a chemical process that converts carbon dioxide into valuable molecules using membrane technology. The strategy followed in this project is two-fold: i) CO2 membrane-based absorption-crystallization process on basis of using amino-acid salts, and ii) CO2 conversion into glucose or salts by using enzymes as catalysts supported on or retained by membranes. The final product, i.e. (bi)carbonates or glucose, has a large interest in the (bio)chemical industry, thus, new CO2 emissions are avoided and the carbon cycle is closed. This project will provide a technological solution at industrial scale for the removal and reutilization of CO2.
Summary
The continued increase in the atmospheric concentration of CO2 due to anthropogenic emissions is leading to significant changes in climate, with the industry accounting for one-third of all the energy used globally and for almost 40% of worldwide CO2 emissions. Fast actions are required to decrease the concentration of this greenhouse gas in the atmosphere, value that has currently reaching 400 ppm. Among the technological possibilities that are on the table to reduce CO2 emissions, carbon capture and storage into geological deposits is one of the main strategies that is being applied. However, the final objective of this strategy is to remove CO2 without considering the enormous potential of this molecule as a source of carbon for the production of valuable compounds. Nature has developed an effective and equilibrated mechanism to concentrate CO2 and fixate the inorganic carbon into organic material (e.g., glucose) by means of enzymatic action. Mimicking Nature and take advantage of millions of years of evolution should be considered as a basic starting point in the development of smart and highly effective processes. In addition, the use of amino-acid salts for CO2 capture is envisaged as a potential approach to recover CO2 in the form of (bi)carbonates.
The project CO2LIFE presents the overall objective of developing a chemical process that converts carbon dioxide into valuable molecules using membrane technology. The strategy followed in this project is two-fold: i) CO2 membrane-based absorption-crystallization process on basis of using amino-acid salts, and ii) CO2 conversion into glucose or salts by using enzymes as catalysts supported on or retained by membranes. The final product, i.e. (bi)carbonates or glucose, has a large interest in the (bio)chemical industry, thus, new CO2 emissions are avoided and the carbon cycle is closed. This project will provide a technological solution at industrial scale for the removal and reutilization of CO2.
Max ERC Funding
1 302 710 €
Duration
Start date: 2018-01-01, End date: 2022-12-31
Project acronym COCOON
Project Conformal coating of nanoporous materials
Researcher (PI) Christophe Detavernier
Host Institution (HI) UNIVERSITEIT GENT
Call Details Starting Grant (StG), PE8, ERC-2009-StG
Summary CONTEXT - Nanoporous structures are used for application in catalysis, molecular separation, fuel cells, dye sensitized solar cells etc. Given the near molecular size of the porous network, it is extremely challenging to modify the interior surface of the pores after the nanoporous material has been synthesized.
THIS PROPOSAL - Atomic Layer Deposition (ALD) is envisioned as a novel technique for creating catalytically active sites and for controlling the pore size distribution in nanoporous materials. ALD is a self-limited growth method that is characterized by alternating exposure of the growing film to precursor vapours, resulting in the sequential deposition of (sub)monolayers. It provides atomic level control of thickness and composition, and is currently used in micro-electronics to grow films into structures with aspect ratios of up to 100 / 1. We aim to make the fundamental breakthroughs necessary to enable atomic layer deposition to engineer the composition, size and shape of the interior surface of nanoporous materials with aspect ratios in excess of 10,000 / 1.
POTENTIAL IMPACT Achieving these objectives will enable atomic level engineering of the interior surface of any porous material. We plan to focus on three specific applications where our results will have both medium and long term impacts:
- Engineering the composition of pore walls using ALD, e.g. to create catalytic sites (e.g. Al for acid sites, Ti for redox sites, or Pt, Pd or Ni)
- chemical functionalization of the pore walls with atomic level control can result in breakthrough applications in the fields of catalysis and sensors.
- Atomic level control of the size of nanopores through ALD controlling the pore size distribution of molecular sieves can potentially lead to breakthrough applications in molecular separation and filtration.
- Nanocasting replication of a mesoporous template by means of ALD can result in the mass-scale production of nanotubes.
Summary
CONTEXT - Nanoporous structures are used for application in catalysis, molecular separation, fuel cells, dye sensitized solar cells etc. Given the near molecular size of the porous network, it is extremely challenging to modify the interior surface of the pores after the nanoporous material has been synthesized.
THIS PROPOSAL - Atomic Layer Deposition (ALD) is envisioned as a novel technique for creating catalytically active sites and for controlling the pore size distribution in nanoporous materials. ALD is a self-limited growth method that is characterized by alternating exposure of the growing film to precursor vapours, resulting in the sequential deposition of (sub)monolayers. It provides atomic level control of thickness and composition, and is currently used in micro-electronics to grow films into structures with aspect ratios of up to 100 / 1. We aim to make the fundamental breakthroughs necessary to enable atomic layer deposition to engineer the composition, size and shape of the interior surface of nanoporous materials with aspect ratios in excess of 10,000 / 1.
POTENTIAL IMPACT Achieving these objectives will enable atomic level engineering of the interior surface of any porous material. We plan to focus on three specific applications where our results will have both medium and long term impacts:
- Engineering the composition of pore walls using ALD, e.g. to create catalytic sites (e.g. Al for acid sites, Ti for redox sites, or Pt, Pd or Ni)
- chemical functionalization of the pore walls with atomic level control can result in breakthrough applications in the fields of catalysis and sensors.
- Atomic level control of the size of nanopores through ALD controlling the pore size distribution of molecular sieves can potentially lead to breakthrough applications in molecular separation and filtration.
- Nanocasting replication of a mesoporous template by means of ALD can result in the mass-scale production of nanotubes.
Max ERC Funding
1 432 800 €
Duration
Start date: 2010-01-01, End date: 2014-12-31
Project acronym COLORTTH
Project The Higgs: A colored View from the Top at ATLAS
Researcher (PI) Reinhild Fatima Yvonne Peters
Host Institution (HI) THE UNIVERSITY OF MANCHESTER
Call Details Starting Grant (StG), PE2, ERC-2013-StG
Summary "With the ground-breaking discovery of a new, Higgs-like boson on July 4th, 2012, by the CMS and ATLAS collaborations at CERN, a new era of particle physics has begun. The discovery is the first step in answering an unsolved problem in particle physics, the question how fundamental bosons and fermions acquire their mass. One of the major goals in collider physics in the next few years will be the deeper insight into the nature of the new particle, its connection to the known fundamental particles and possible extensions beyond the standard model (SM) of particle physics.
My project aims at a particular interesting field to study, the relation of the new particle with the heaviest known elementary particle, the top quark. I aim to develop new, innovative techniques and beyond state-of-the-art methods to extract the Yukawa coupling between the top quark and the Higgs boson, which is expected to be of the order of one - much higher than that of any other quark. I will analyse the only process where the top-Higgs Yukawa coupling can be measured, in associated production of top quark pairs and a Higgs boson. The Higgs boson mainly decays into a pair of b-quarks. This is one of the most challenging channels at the LHC, as huge background processes from gluon splitting contribute. In particular, I will develop and study color flow variables, which provide a unique, powerful technique to distinguish color singlet Higgs bosons from the main background, color octet gluons.
The ultimate goal of the project is the first measurement of the top-Higgs Yukawa coupling and its confrontation with SM and beyond SM Higgs boson models, resulting in an unprecedented insight into the fundamental laws of nature.
The LHC will soon reach a new energy frontier of 13 TeV starting in 2014. This new environment will provide never seen opportunities to study hints of new physics and precisely measure properties of the newly found particle. This sets the stage for the project."
Summary
"With the ground-breaking discovery of a new, Higgs-like boson on July 4th, 2012, by the CMS and ATLAS collaborations at CERN, a new era of particle physics has begun. The discovery is the first step in answering an unsolved problem in particle physics, the question how fundamental bosons and fermions acquire their mass. One of the major goals in collider physics in the next few years will be the deeper insight into the nature of the new particle, its connection to the known fundamental particles and possible extensions beyond the standard model (SM) of particle physics.
My project aims at a particular interesting field to study, the relation of the new particle with the heaviest known elementary particle, the top quark. I aim to develop new, innovative techniques and beyond state-of-the-art methods to extract the Yukawa coupling between the top quark and the Higgs boson, which is expected to be of the order of one - much higher than that of any other quark. I will analyse the only process where the top-Higgs Yukawa coupling can be measured, in associated production of top quark pairs and a Higgs boson. The Higgs boson mainly decays into a pair of b-quarks. This is one of the most challenging channels at the LHC, as huge background processes from gluon splitting contribute. In particular, I will develop and study color flow variables, which provide a unique, powerful technique to distinguish color singlet Higgs bosons from the main background, color octet gluons.
The ultimate goal of the project is the first measurement of the top-Higgs Yukawa coupling and its confrontation with SM and beyond SM Higgs boson models, resulting in an unprecedented insight into the fundamental laws of nature.
The LHC will soon reach a new energy frontier of 13 TeV starting in 2014. This new environment will provide never seen opportunities to study hints of new physics and precisely measure properties of the newly found particle. This sets the stage for the project."
Max ERC Funding
1 163 755 €
Duration
Start date: 2014-02-01, End date: 2019-01-31
Project acronym COMUNEM
Project Computational Multiscale Neuron Mechanics
Researcher (PI) Antoine Guy Bernard Jerusalem
Host Institution (HI) THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Call Details Starting Grant (StG), PE8, ERC-2012-StG_20111012
Summary "The last few years have seen a growing interest for computational cell mechanics. This field encompasses different scales ranging from individual monomers, cytoskeleton constituents, up to the full cell. Its focus, fueled by the development of interdisciplinary collaborative efforts between engineering, computer science and biology, until recently relatively isolated, has allowed for important breakthroughs in biomedicine, bioengineering or even neurology. However, the natural “knowledge barrier” between fields often leads to the use of one numerical tool for one bioengineering application with a limited understanding of either the tool or the field of application itself. Few groups, to date, have the knowledge and expertise to properly avoid both pits. Within the computational mechanics realm, new methods aim at bridging scale and modeling techniques ranging from density functional theory up to continuum modeling on very large scale parallel supercomputers. To the best of the knowledge of the author, a thorough and comprehensive research campaign aiming at bridging scales from proteins to the cell level while including its interaction with its surrounding media/stimulus is yet to be done. Among all cells, neurons are at the heart of tremendous medical challenges (TBI, Alzheimer, etc.). In nearly all of these challenges, the intrinsic coupling between mechanical and chemical mechanisms in neuron is of drastic relevance. I thus propose here the development of a neuron model constituted of length-scale dedicated numerical techniques, adequately bridged together. As an illustration of its usability, the model will be used for two specific applications: neurite growth and electrical-chemical-mechanical coupling in neurons. This multiscale computational framework will ultimately be made available to the bio- medical community to enhance their knowledge on neuron deformation, growth, electrosignaling and thus, Alzheimer’s disease, cancer or TBI."
Summary
"The last few years have seen a growing interest for computational cell mechanics. This field encompasses different scales ranging from individual monomers, cytoskeleton constituents, up to the full cell. Its focus, fueled by the development of interdisciplinary collaborative efforts between engineering, computer science and biology, until recently relatively isolated, has allowed for important breakthroughs in biomedicine, bioengineering or even neurology. However, the natural “knowledge barrier” between fields often leads to the use of one numerical tool for one bioengineering application with a limited understanding of either the tool or the field of application itself. Few groups, to date, have the knowledge and expertise to properly avoid both pits. Within the computational mechanics realm, new methods aim at bridging scale and modeling techniques ranging from density functional theory up to continuum modeling on very large scale parallel supercomputers. To the best of the knowledge of the author, a thorough and comprehensive research campaign aiming at bridging scales from proteins to the cell level while including its interaction with its surrounding media/stimulus is yet to be done. Among all cells, neurons are at the heart of tremendous medical challenges (TBI, Alzheimer, etc.). In nearly all of these challenges, the intrinsic coupling between mechanical and chemical mechanisms in neuron is of drastic relevance. I thus propose here the development of a neuron model constituted of length-scale dedicated numerical techniques, adequately bridged together. As an illustration of its usability, the model will be used for two specific applications: neurite growth and electrical-chemical-mechanical coupling in neurons. This multiscale computational framework will ultimately be made available to the bio- medical community to enhance their knowledge on neuron deformation, growth, electrosignaling and thus, Alzheimer’s disease, cancer or TBI."
Max ERC Funding
1 128 960 €
Duration
Start date: 2013-05-01, End date: 2018-04-30
Project acronym CORREL-CT
Project Correlative tomography
Researcher (PI) Philip Withers
Host Institution (HI) THE UNIVERSITY OF MANCHESTER
Call Details Advanced Grant (AdG), PE8, ERC-2015-AdG
Summary Proposal summary (half page)
The vision is firstly, to develop correlative tomography to radically increase the nature and level of information (morphological, structural and chemical) that can be obtained for a 3D volume of interest (VoI) deep within a material or component by coupling non-destructive (3D+time) X-ray tomography with destructive (3D) electron tomography and, secondly to exploit this new approach to shed light on damage accumulation processes arising under demanding conditions. Successful completion of this project will provide new 3D & 4D insights across many areas and yield key experimental data for multiscale models.
Objective 1: To build the capability of correlative tomography
- To connect platforms across scales and modalities in order to track a VoI that may be located deep below the surface and to combine multiple techniques within a single platform.
- To add new facets to correlative tomography including
+ 3D chemical imaging
+ 3D crystal grain mapping
+ the local stress distribution
+ mechanical performance mapping at the VoI scale
Objective 2: To apply it to gain new insights into damage accumulation
Correlative tomography will provide a much richer multi-faceted hierarchical picture of materials behaviour from life science to food science from geology to cultural heritage. This project will focus specifically on identifying the nucleation, propagation and aggregation of damage processes in engineering materials.
- We will identify and track the mechanisms that control the progressive degradation of conventional bulk engineering materials operating under demanding conditions.
- We will examine the hierarchical strategies nature uses to control failure in natural materials through heterogeneous chemistry, morphology and properties. Alongside this we will examine the behaviour of man-made nano-structured analogues and whether we can exploit some of these strategies.
Summary
Proposal summary (half page)
The vision is firstly, to develop correlative tomography to radically increase the nature and level of information (morphological, structural and chemical) that can be obtained for a 3D volume of interest (VoI) deep within a material or component by coupling non-destructive (3D+time) X-ray tomography with destructive (3D) electron tomography and, secondly to exploit this new approach to shed light on damage accumulation processes arising under demanding conditions. Successful completion of this project will provide new 3D & 4D insights across many areas and yield key experimental data for multiscale models.
Objective 1: To build the capability of correlative tomography
- To connect platforms across scales and modalities in order to track a VoI that may be located deep below the surface and to combine multiple techniques within a single platform.
- To add new facets to correlative tomography including
+ 3D chemical imaging
+ 3D crystal grain mapping
+ the local stress distribution
+ mechanical performance mapping at the VoI scale
Objective 2: To apply it to gain new insights into damage accumulation
Correlative tomography will provide a much richer multi-faceted hierarchical picture of materials behaviour from life science to food science from geology to cultural heritage. This project will focus specifically on identifying the nucleation, propagation and aggregation of damage processes in engineering materials.
- We will identify and track the mechanisms that control the progressive degradation of conventional bulk engineering materials operating under demanding conditions.
- We will examine the hierarchical strategies nature uses to control failure in natural materials through heterogeneous chemistry, morphology and properties. Alongside this we will examine the behaviour of man-made nano-structured analogues and whether we can exploit some of these strategies.
Max ERC Funding
2 926 425 €
Duration
Start date: 2016-11-01, End date: 2021-10-31
Project acronym COSMOLAB
Project Laboratory simulation of cosmological magnetic fields
Researcher (PI) Gianluca Gregori
Host Institution (HI) THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Call Details Starting Grant (StG), PE2, ERC-2010-StG_20091028
Summary The advent of high-power laser systems in the past two decades has opened a new field of research where astrophysical environments can be scaled down to laboratory dimensions, yet preserving the essential physics. This is due to the invariance of the equations of ideal magneto-hydrodynamics (MHD) to a class of self-similar transformations. In this proposal, we will apply these scaling laws to investigate the dynamics of the high Mach number shocks arising during the formation of the large-scale structure of the Universe. Although at the beginning of cosmic evolution matter was nearly homogenously distributed, today, as a result of gravitational instability, it forms a web-like structure made of filaments and clusters. Gas continues to accrete supersonically onto these collapsed structures, thus producing high Mach number shocks. It has been recently proposed that generation of magnetic fields can occur at these cosmic shocks on a cosmologically fast timescale via a Weibel-like instability, thus providing an appealing explanation to the ubiquitous magnetization of the Universe. Our proposal will thus provide the first experimental evidence of such mechanisms. We plan to measure the self-generated magnetic fields from laboratory shock waves using a novel combination of electron deflectometry, Faraday rotation measurements using THz lasers, and dB/dt probes. The proposed investigation on the generation of magnetic fields at shocks via plasma instabilities bears important general consequences. First, it will shed light on the origin of cosmic magnetic fields. Second, it would have a tremendous impact on one of the greatest puzzles of high energy astrophysics, the origin of Ultra High Energy Cosmic Rays. We plan to assess the role of charged particle acceleration via collisionless shocks in the amplification of the magnetic field as well as measure the spectrum of such accelerated particles. The experimental work will be carried both at Oxford U and at laser facilities.
Summary
The advent of high-power laser systems in the past two decades has opened a new field of research where astrophysical environments can be scaled down to laboratory dimensions, yet preserving the essential physics. This is due to the invariance of the equations of ideal magneto-hydrodynamics (MHD) to a class of self-similar transformations. In this proposal, we will apply these scaling laws to investigate the dynamics of the high Mach number shocks arising during the formation of the large-scale structure of the Universe. Although at the beginning of cosmic evolution matter was nearly homogenously distributed, today, as a result of gravitational instability, it forms a web-like structure made of filaments and clusters. Gas continues to accrete supersonically onto these collapsed structures, thus producing high Mach number shocks. It has been recently proposed that generation of magnetic fields can occur at these cosmic shocks on a cosmologically fast timescale via a Weibel-like instability, thus providing an appealing explanation to the ubiquitous magnetization of the Universe. Our proposal will thus provide the first experimental evidence of such mechanisms. We plan to measure the self-generated magnetic fields from laboratory shock waves using a novel combination of electron deflectometry, Faraday rotation measurements using THz lasers, and dB/dt probes. The proposed investigation on the generation of magnetic fields at shocks via plasma instabilities bears important general consequences. First, it will shed light on the origin of cosmic magnetic fields. Second, it would have a tremendous impact on one of the greatest puzzles of high energy astrophysics, the origin of Ultra High Energy Cosmic Rays. We plan to assess the role of charged particle acceleration via collisionless shocks in the amplification of the magnetic field as well as measure the spectrum of such accelerated particles. The experimental work will be carried both at Oxford U and at laser facilities.
Max ERC Funding
1 119 690 €
Duration
Start date: 2010-12-01, End date: 2015-11-30
Project acronym CounterLIGHT
Project Interaction and Symmetry Breaking of Counterpropagating Light
Researcher (PI) Pascal Del Haye
Host Institution (HI) NPL MANAGEMENT LIMITED
Call Details Starting Grant (StG), PE2, ERC-2017-STG
Summary Light is generally expected to travel through media independent of its direction. Exceptions can be achieved eg. through polarization changes induced by magnetic fields (known as the Faraday effect) together with polarization-sensitive birefringent materials. However, light can also be influenced by the presence of a counterpropagating light wave. We have recently shown that this leads to the surprising consequence that light sent into tiny glass rings (microresonators) can only propagate in one direction, clockwise or counterclockwise, but not in both directions simultaneously. When sending exactly the same state of light (same power and polarization) into a microresonator, nonlinear interaction induces a spontaneous symmetry breaking in the propagation of light. In this proposal we plan to investigate the fundamental physics and a variety of ground-breaking applications of this effect. In one proposed application, this effect will be used for optical nonreciprocity and the realization of optical diodes in integrated photonic circuits that do not rely on magnetic fields (an important key element in integrated photonics). In another proposed experiment we plan to use the spontaneous symmetry breaking to demonstrate microresonator-based optical gyroscopes that have the potential to beat state-of-the-art sensors in both size and sensitivity. Additional research projects include experiments with all-optical logic gates, photonic memories, and near field sensors based on counterpropagating light states. Finally, we plan to demonstrate a microresonator-based system for the generation of dual-optical frequency combs that can be used for real-time precision spectroscopy in future lab-on-a-chip applications. On the fundamental physics side, our experiments investigate the interaction of counterpropagating light in a system with periodic boundary conditions. The fundamental nature of this system has the potential to impact other fields of science far beyond optical physics.
Summary
Light is generally expected to travel through media independent of its direction. Exceptions can be achieved eg. through polarization changes induced by magnetic fields (known as the Faraday effect) together with polarization-sensitive birefringent materials. However, light can also be influenced by the presence of a counterpropagating light wave. We have recently shown that this leads to the surprising consequence that light sent into tiny glass rings (microresonators) can only propagate in one direction, clockwise or counterclockwise, but not in both directions simultaneously. When sending exactly the same state of light (same power and polarization) into a microresonator, nonlinear interaction induces a spontaneous symmetry breaking in the propagation of light. In this proposal we plan to investigate the fundamental physics and a variety of ground-breaking applications of this effect. In one proposed application, this effect will be used for optical nonreciprocity and the realization of optical diodes in integrated photonic circuits that do not rely on magnetic fields (an important key element in integrated photonics). In another proposed experiment we plan to use the spontaneous symmetry breaking to demonstrate microresonator-based optical gyroscopes that have the potential to beat state-of-the-art sensors in both size and sensitivity. Additional research projects include experiments with all-optical logic gates, photonic memories, and near field sensors based on counterpropagating light states. Finally, we plan to demonstrate a microresonator-based system for the generation of dual-optical frequency combs that can be used for real-time precision spectroscopy in future lab-on-a-chip applications. On the fundamental physics side, our experiments investigate the interaction of counterpropagating light in a system with periodic boundary conditions. The fundamental nature of this system has the potential to impact other fields of science far beyond optical physics.
Max ERC Funding
1 500 000 €
Duration
Start date: 2018-03-01, End date: 2023-02-28
Project acronym CRYSYS
Project Crystallisation Systems Engineering – Towards a next generation of intelligent crystallisation systems
Researcher (PI) Zoltan Kalman Nagy
Host Institution (HI) LOUGHBOROUGH UNIVERSITY
Call Details Starting Grant (StG), PE8, ERC-2011-StG_20101014
Summary The project proposes the development of an intelligent crystallisation system by combining state-of-the-art process analytical technologies and novel model-based and statistical feedback control approaches, to provide a fully integrated and adaptive system for efficient engineering of particulate products. The developed adaptive and robust control approaches will be incorporated in a Crystallisation Process Informatics System, to provide an intelligent decision support system, which triggers the suitable control algorithm taking into account the effect of crystallisation on the downstream processing units and final product properties. In this way crystallisation becomes a key intelligent “process actuator” in the whole production system, that manipulates final properties of the solid product taking into account operational, regulatory and economic constraints of the entire process, opening the way towards novel product engineering approaches. The project will bring the implementation of a new generation of integrated, intensified and intelligent crystallisation systems with drastically improved flexibility, predictability, stability and controllability. The system will be used for detailed evaluation of the current paradigm shift from batch to continuous processes in the pharmaceutical industries. Besides providing a breakthrough in crystallisation science the results could revolutionise the methods in which crystallisation will be designed and controlled in the future, yielding to the development of the emerging research field of Pharmaceutical Systems Engineering, by providing a comprehensive framework for the development of novel integrated pharmaceutical production units and product engineering technologies, for sustainable pharmaceutical production, with the aim of reducing time-to-market and increasing product quality, therefore providing considerable increase in quality of life, for example, by making new products available more quickly and at lower cost.
Summary
The project proposes the development of an intelligent crystallisation system by combining state-of-the-art process analytical technologies and novel model-based and statistical feedback control approaches, to provide a fully integrated and adaptive system for efficient engineering of particulate products. The developed adaptive and robust control approaches will be incorporated in a Crystallisation Process Informatics System, to provide an intelligent decision support system, which triggers the suitable control algorithm taking into account the effect of crystallisation on the downstream processing units and final product properties. In this way crystallisation becomes a key intelligent “process actuator” in the whole production system, that manipulates final properties of the solid product taking into account operational, regulatory and economic constraints of the entire process, opening the way towards novel product engineering approaches. The project will bring the implementation of a new generation of integrated, intensified and intelligent crystallisation systems with drastically improved flexibility, predictability, stability and controllability. The system will be used for detailed evaluation of the current paradigm shift from batch to continuous processes in the pharmaceutical industries. Besides providing a breakthrough in crystallisation science the results could revolutionise the methods in which crystallisation will be designed and controlled in the future, yielding to the development of the emerging research field of Pharmaceutical Systems Engineering, by providing a comprehensive framework for the development of novel integrated pharmaceutical production units and product engineering technologies, for sustainable pharmaceutical production, with the aim of reducing time-to-market and increasing product quality, therefore providing considerable increase in quality of life, for example, by making new products available more quickly and at lower cost.
Max ERC Funding
1 263 702 €
Duration
Start date: 2011-09-01, End date: 2017-08-31
Project acronym DARKFRONTIER
Project Fundamental Physics at the Low Background Frontier
Researcher (PI) Jocelyn Monroe
Host Institution (HI) ROYAL HOLLOWAY AND BEDFORD NEW COLLEGE
Call Details Starting Grant (StG), PE2, ERC-2011-StG_20101014
Summary The nature of dark matter is one of the fundamental questions in physics today. Direct signals for dark matter have remained elusive, indicating that multi-tonne scale detectors are needed to measure large numbers of dark matter interactions, while current efforts are at the 100 kg scale. The foremost challenge is distinguishing dark matter signals from backgrounds, the most uncertain of which are from neutrons. The research objective of this proposal is a world-leading dark matter search with a novel liquid argon (LAr) detector and a new analysis approach to measuring neutron backgrounds in-situ.
The DEAP/CLEAN program of single-phase LAr detectors is a new direction for dark matter searches. It draws on successful, proven approaches of solar neutrino physics to building low-background detectors that scale simply to multi-tonne target masses. Demonstration of this approach by the current 100 kg stage (MiniCLEAN) will break new ground for future experiments. At the 100 tonne scale, such a detector would be a new kind of observatory for fundamental physics at the low background frontier, testing predicted properties of dark matter, neutrinos, supernovae, and stellar evolution. Success depends critically on demonstrating the required background suppression.
This proposal addresses the key challenges of dark matter detection in two new ways, with the novel single-phase effort for multi-tonne scalability, and by developing new methods to overcome neutron backgrounds. The tasks of this proposal are: (i) to develop a measurement of the in-situ neutron background in LAr; (ii) to develop an active neutron veto for in-situ measurement of the cosmogenic neutron background, beginning with a measurement of the flux and energy spectrum in an existing prototype; and, (iii) to lead the dark matter search, using the measured backgrounds. The MiniCLEAN dark matter sensitivity is a factor of 20 beyond current experimental results, with great potential for discovery.
Summary
The nature of dark matter is one of the fundamental questions in physics today. Direct signals for dark matter have remained elusive, indicating that multi-tonne scale detectors are needed to measure large numbers of dark matter interactions, while current efforts are at the 100 kg scale. The foremost challenge is distinguishing dark matter signals from backgrounds, the most uncertain of which are from neutrons. The research objective of this proposal is a world-leading dark matter search with a novel liquid argon (LAr) detector and a new analysis approach to measuring neutron backgrounds in-situ.
The DEAP/CLEAN program of single-phase LAr detectors is a new direction for dark matter searches. It draws on successful, proven approaches of solar neutrino physics to building low-background detectors that scale simply to multi-tonne target masses. Demonstration of this approach by the current 100 kg stage (MiniCLEAN) will break new ground for future experiments. At the 100 tonne scale, such a detector would be a new kind of observatory for fundamental physics at the low background frontier, testing predicted properties of dark matter, neutrinos, supernovae, and stellar evolution. Success depends critically on demonstrating the required background suppression.
This proposal addresses the key challenges of dark matter detection in two new ways, with the novel single-phase effort for multi-tonne scalability, and by developing new methods to overcome neutron backgrounds. The tasks of this proposal are: (i) to develop a measurement of the in-situ neutron background in LAr; (ii) to develop an active neutron veto for in-situ measurement of the cosmogenic neutron background, beginning with a measurement of the flux and energy spectrum in an existing prototype; and, (iii) to lead the dark matter search, using the measured backgrounds. The MiniCLEAN dark matter sensitivity is a factor of 20 beyond current experimental results, with great potential for discovery.
Max ERC Funding
1 063 174 €
Duration
Start date: 2011-09-01, End date: 2017-08-31
Project acronym DARKHORIZONS
Project Dark Matter and the Early Universe in the LHC Era
Researcher (PI) Malcolm Douglas Stephen Fairbairn
Host Institution (HI) KING'S COLLEGE LONDON
Call Details Consolidator Grant (CoG), PE2, ERC-2014-CoG
Summary The discovery of a Higgs like particle in its first science run shows that we are truly in the LHC era and when collisions resume we will learn more about the physics of the TeV scale.
There are two main areas at the interface of particle physics and cosmology that the LHC will shed light on - If dark matter is a thermal relic then we naturally expect new particle physics close to this TeV energy range. The LHC will also help us learn about the nature of the electroweak sector and its behaviour during the early Universe.
In this proposal we present a body of work which will combine information from the LHC with dark matter experiments and astronomical observations to understand both the nature of dark matter and the role of the Higgs sector in the first moments after the big bang.
We will investigate dark matter by developing a new categorisation of interactions between the dark sector and the standard model. This will enable us to perform detailed collider and direct detection phenomenology in a more comprehensive way than current approaches while avoiding the problems which occur when those methods breakdown. Different schemes for mitigating against the upcoming problem of the neutrino floor in direct detection experiments will also be investigated.
Many of the keys to understanding the particle nature of dark matter lie in astrophysics, and we will develop new techniques to understand the distribution of dark matter in the Universe, its behaviour and density in distant galaxies and its velocity dispersion in the Solar system, critical to predict event rates in detectors.
We will use LHC and CMB data to answer important questions - Can the electroweak phase transition be first order? What is the role of the Higgs field during inflation? Can we use the electroweak sector to infer information about physics at high energy scale or the nature of inflation?
The interdisciplinary experience of the PI will ensure the ambitious project is a success.
Summary
The discovery of a Higgs like particle in its first science run shows that we are truly in the LHC era and when collisions resume we will learn more about the physics of the TeV scale.
There are two main areas at the interface of particle physics and cosmology that the LHC will shed light on - If dark matter is a thermal relic then we naturally expect new particle physics close to this TeV energy range. The LHC will also help us learn about the nature of the electroweak sector and its behaviour during the early Universe.
In this proposal we present a body of work which will combine information from the LHC with dark matter experiments and astronomical observations to understand both the nature of dark matter and the role of the Higgs sector in the first moments after the big bang.
We will investigate dark matter by developing a new categorisation of interactions between the dark sector and the standard model. This will enable us to perform detailed collider and direct detection phenomenology in a more comprehensive way than current approaches while avoiding the problems which occur when those methods breakdown. Different schemes for mitigating against the upcoming problem of the neutrino floor in direct detection experiments will also be investigated.
Many of the keys to understanding the particle nature of dark matter lie in astrophysics, and we will develop new techniques to understand the distribution of dark matter in the Universe, its behaviour and density in distant galaxies and its velocity dispersion in the Solar system, critical to predict event rates in detectors.
We will use LHC and CMB data to answer important questions - Can the electroweak phase transition be first order? What is the role of the Higgs field during inflation? Can we use the electroweak sector to infer information about physics at high energy scale or the nature of inflation?
The interdisciplinary experience of the PI will ensure the ambitious project is a success.
Max ERC Funding
1 947 665 €
Duration
Start date: 2015-09-01, End date: 2020-08-31
Project acronym DEFTPORE
Project Deformation control on flow and transport in soft porous media
Researcher (PI) Christopher MacMinn
Host Institution (HI) THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Call Details Starting Grant (StG), PE8, ERC-2018-STG
Summary Fluid flows through soft porous media are ubiquitous across nature and industry, from methane bubbles rising through lakebed and seabed sediments to nutrient transport in living cells and tissues to the manufacturing of paper products and many composites. Despite their ubiquity, flow and transport in these systems remain at the frontier of our ability to measure and model. A defining feature of soft porous media is that they can experience deformations that transform the pore structure. This has profound implications for the transport and mixing of solutes and the simultaneous flow of multiple fluid phases, both of which are strongly coupled to the pore structure. The goal of this project is to shed new light on flow and transport in soft porous media by studying a series of three canonical flow problems (tracer transport, miscible viscous fingering, and two-phase flow) across soft adaptations of three classical model systems (a soft-walled Hele Shaw cell, a quasi-2D packing of soft beads, and a cylindrical 3D “core” of soft beads). These flow problems and model systems have been thoroughly studied in the context of stiff porous media, allowing us to leverage decades of previous work and focus exclusively on the new behaviour introduced by “softness”. We will collect an extensive set of new, high-resolution experimental observations in each of these model systems, and we will reconcile these observations with mathematical models based on the traditional approach of upscaled constitutive functions. By updating this traditional approach to account for deformation, we will provide a new, pragmatic class of continuum models that capture the leading-order features of flow and transport in soft porous media. Our results will jumpstart the field of flow and transport in soft porous media, breaking open a vast new realm of research questions and applications around understanding, predicting, and controlling these complex systems.
Summary
Fluid flows through soft porous media are ubiquitous across nature and industry, from methane bubbles rising through lakebed and seabed sediments to nutrient transport in living cells and tissues to the manufacturing of paper products and many composites. Despite their ubiquity, flow and transport in these systems remain at the frontier of our ability to measure and model. A defining feature of soft porous media is that they can experience deformations that transform the pore structure. This has profound implications for the transport and mixing of solutes and the simultaneous flow of multiple fluid phases, both of which are strongly coupled to the pore structure. The goal of this project is to shed new light on flow and transport in soft porous media by studying a series of three canonical flow problems (tracer transport, miscible viscous fingering, and two-phase flow) across soft adaptations of three classical model systems (a soft-walled Hele Shaw cell, a quasi-2D packing of soft beads, and a cylindrical 3D “core” of soft beads). These flow problems and model systems have been thoroughly studied in the context of stiff porous media, allowing us to leverage decades of previous work and focus exclusively on the new behaviour introduced by “softness”. We will collect an extensive set of new, high-resolution experimental observations in each of these model systems, and we will reconcile these observations with mathematical models based on the traditional approach of upscaled constitutive functions. By updating this traditional approach to account for deformation, we will provide a new, pragmatic class of continuum models that capture the leading-order features of flow and transport in soft porous media. Our results will jumpstart the field of flow and transport in soft porous media, breaking open a vast new realm of research questions and applications around understanding, predicting, and controlling these complex systems.
Max ERC Funding
1 482 862 €
Duration
Start date: 2019-02-01, End date: 2024-01-31
Project acronym DIGT
Project Diffeomorphism Invariant Gauge Theories, Asymptotic Safety and Geometry
Researcher (PI) Kirill Krasnov
Host Institution (HI) THE UNIVERSITY OF NOTTINGHAM
Call Details Starting Grant (StG), PE2, ERC-2011-StG_20101014
Summary The aim of the proposed research is to develop a new description of gravity in four spacetime dimensions. This will (i) serve as a new tool to investigate the conjecture that four-dimensional quantum gravity may be ultra-violet complete (asymptotically safe); (ii) provide new techniques for the problem of classification of geometric structures on four-manifolds. To this end we shall study a certain large class of diffeomorphism invariant SU(2) gauge theories. The low-energy physics of these theories is known to be indistinguishable from that of general relativity (GR). At high energies, they provide an interesting type of deformations of GR, with the key property that the number of propagating degrees of freedom is the same as in general relativity. To test the asymptotic safety conjecture we shall perform perturbative one-loop computations to determine how these theories are renormalized by quantum corrections and then study the resulting renormalization group flow. The same class of theories will also be used to solve some of fundamental conjectures about the geometric structures on four-manifolds. The most optimistic scenario results will prove the asymptotic safety in four-dimensional quantum gravity and explicitly describe the physics occurring around the ultra-violet fixed point. The impact of this on theoretical physics will be comparable to the impact of the 1973 discovery of asymptotic freedom on the high energy physics. The work on the proposal will involve some of the world leading scientists as collaborators and advisors. The project will be carried out in the School of Mathematical Sciences at the University of Nottingham, one of the major mathematics research centres in the UK. Regular long-term research visits to our group by leading scientists, as well as three meetings planned will establish the PI Nottingham research group as one of the leading European centres in the subject area.
Summary
The aim of the proposed research is to develop a new description of gravity in four spacetime dimensions. This will (i) serve as a new tool to investigate the conjecture that four-dimensional quantum gravity may be ultra-violet complete (asymptotically safe); (ii) provide new techniques for the problem of classification of geometric structures on four-manifolds. To this end we shall study a certain large class of diffeomorphism invariant SU(2) gauge theories. The low-energy physics of these theories is known to be indistinguishable from that of general relativity (GR). At high energies, they provide an interesting type of deformations of GR, with the key property that the number of propagating degrees of freedom is the same as in general relativity. To test the asymptotic safety conjecture we shall perform perturbative one-loop computations to determine how these theories are renormalized by quantum corrections and then study the resulting renormalization group flow. The same class of theories will also be used to solve some of fundamental conjectures about the geometric structures on four-manifolds. The most optimistic scenario results will prove the asymptotic safety in four-dimensional quantum gravity and explicitly describe the physics occurring around the ultra-violet fixed point. The impact of this on theoretical physics will be comparable to the impact of the 1973 discovery of asymptotic freedom on the high energy physics. The work on the proposal will involve some of the world leading scientists as collaborators and advisors. The project will be carried out in the School of Mathematical Sciences at the University of Nottingham, one of the major mathematics research centres in the UK. Regular long-term research visits to our group by leading scientists, as well as three meetings planned will establish the PI Nottingham research group as one of the leading European centres in the subject area.
Max ERC Funding
1 222 830 €
Duration
Start date: 2012-01-01, End date: 2017-06-30
Project acronym DIMO6FIT
Project DIMO6FIT: Extending the Standard Model -- Global Fits of Optimal Variables in Diboson Production
Researcher (PI) Kristin LOHWASSER
Host Institution (HI) THE UNIVERSITY OF SHEFFIELD
Call Details Starting Grant (StG), PE2, ERC-2016-STG
Summary The status quo of particle physics after the first data taking at the Large Hadron Collider is: a light Higgs particle has been discovered that is perfectly compatible with the electroweak Standard Model (SM). While this is undoubtedly a historic step in particle physics, it is not entirely satisfactory, as in its current state the SM leaves many questions unanswered.
If the Standard Model of today is just the low energy theory of more complex phenomena, then these phenomena will become manifest in modifications of the cross sections and differential distributions of known processes. These modifications can be described by higher dimensional operators, which are general extensions of the SM and can be tested using precision measurements of diboson production processes.
The DIMO6Fit project will focus on measuring those production processes most sensitive to the new physics effects, using innovative analysis techniques aimed at significantly reducing the debilitating limitations in current measurements. I will set up a novel combined global fit for determining the higher dimensional operators coherently based on the LHC measurements.
The full determination of the higher dimensional operators will be the first global precision test of general extensions to the SM. The ERC Starting Grant will make it possible to bring together a team that will conduct more efficient measurements then today at the ATLAS experiment, that will establish the framework for new precision tests, and will generate results of yet unforeseeable potential. With DIMO6FIT I will establish an exciting programme aiming at determining the higher dimensional operators, which will help uncover new physics and elucidate its nature. These novel studies will form a unique and significant contribution to the understanding of the fundamental interactions of known and possibly yet unknown particles.
Summary
The status quo of particle physics after the first data taking at the Large Hadron Collider is: a light Higgs particle has been discovered that is perfectly compatible with the electroweak Standard Model (SM). While this is undoubtedly a historic step in particle physics, it is not entirely satisfactory, as in its current state the SM leaves many questions unanswered.
If the Standard Model of today is just the low energy theory of more complex phenomena, then these phenomena will become manifest in modifications of the cross sections and differential distributions of known processes. These modifications can be described by higher dimensional operators, which are general extensions of the SM and can be tested using precision measurements of diboson production processes.
The DIMO6Fit project will focus on measuring those production processes most sensitive to the new physics effects, using innovative analysis techniques aimed at significantly reducing the debilitating limitations in current measurements. I will set up a novel combined global fit for determining the higher dimensional operators coherently based on the LHC measurements.
The full determination of the higher dimensional operators will be the first global precision test of general extensions to the SM. The ERC Starting Grant will make it possible to bring together a team that will conduct more efficient measurements then today at the ATLAS experiment, that will establish the framework for new precision tests, and will generate results of yet unforeseeable potential. With DIMO6FIT I will establish an exciting programme aiming at determining the higher dimensional operators, which will help uncover new physics and elucidate its nature. These novel studies will form a unique and significant contribution to the understanding of the fundamental interactions of known and possibly yet unknown particles.
Max ERC Funding
1 497 000 €
Duration
Start date: 2017-02-01, End date: 2022-01-31
Project acronym DoRES
Project Direct measurements of key nuclear Reactions for the creation of Elements in Stars
Researcher (PI) Claudia Lederer
Host Institution (HI) THE UNIVERSITY OF EDINBURGH
Call Details Starting Grant (StG), PE2, ERC-2015-STG
Summary The evolution of the universe has left an imprint in the form of the chemical elements. Understanding the cosmic origins of the elements remains a major challenge for science. The abundances of elements we see in our solar system, distant stars, meteorites, and in stellar explosions provide us with clues about how the elements came to be produced in a variety of different processes and stellar environments. To unravel these mysteries we need to understand the nuclear reactions producing and destroying the elements. New generation accelerator facilities and instrumentation are being developed in Europe which will enable many of these reactions to be measured directly for the first time, and with high precision. This offers the prospect of a major step forward in the field in the next few years. Many of the key reactions involve unstable nuclei, studied experimentally either by using radioactive beams or targets. These unstable nuclei play a critical role in high temperature stellar environments, most notably stellar explosions. Reactions can occur on the unstable nucleus before it has decayed thereby strongly altering the path of subsequent element synthesis. The proposal is sub-divided into 5 themes, concerning production of the heavy elements in neutron capture reactions, destruction of the cosmic gamma-ray emitter 26Al in core collapse supernovae, neutron source reactions in stars, the puzzle of high abundances of proton-rich heavy isotopes, and the origin of nature’s least abundant isotope 180mTa. Experiments will initially be performed using neutron beams from the upgraded n_TOF facility at CERN including the high flux EAR-2 beam line, and using radioactive beams from the upgraded HIE-ISOLDE facility at CERN. In the later phase of the proposal experiments will also be performed using the new ultra-high intensity neutron beam facility FRANZ at Frankfurt, and with radioactive beams injected into heavy ion storage rings to be installed at GSI and CERN.
Summary
The evolution of the universe has left an imprint in the form of the chemical elements. Understanding the cosmic origins of the elements remains a major challenge for science. The abundances of elements we see in our solar system, distant stars, meteorites, and in stellar explosions provide us with clues about how the elements came to be produced in a variety of different processes and stellar environments. To unravel these mysteries we need to understand the nuclear reactions producing and destroying the elements. New generation accelerator facilities and instrumentation are being developed in Europe which will enable many of these reactions to be measured directly for the first time, and with high precision. This offers the prospect of a major step forward in the field in the next few years. Many of the key reactions involve unstable nuclei, studied experimentally either by using radioactive beams or targets. These unstable nuclei play a critical role in high temperature stellar environments, most notably stellar explosions. Reactions can occur on the unstable nucleus before it has decayed thereby strongly altering the path of subsequent element synthesis. The proposal is sub-divided into 5 themes, concerning production of the heavy elements in neutron capture reactions, destruction of the cosmic gamma-ray emitter 26Al in core collapse supernovae, neutron source reactions in stars, the puzzle of high abundances of proton-rich heavy isotopes, and the origin of nature’s least abundant isotope 180mTa. Experiments will initially be performed using neutron beams from the upgraded n_TOF facility at CERN including the high flux EAR-2 beam line, and using radioactive beams from the upgraded HIE-ISOLDE facility at CERN. In the later phase of the proposal experiments will also be performed using the new ultra-high intensity neutron beam facility FRANZ at Frankfurt, and with radioactive beams injected into heavy ion storage rings to be installed at GSI and CERN.
Max ERC Funding
1 495 479 €
Duration
Start date: 2016-06-01, End date: 2021-05-31
Project acronym DualitiesHEPTH
Project Dualities in Super-symmetric Gauge Theories, String Theory and Conformal Field Theories
Researcher (PI) Luis Fernando Alday
Host Institution (HI) THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Call Details Starting Grant (StG), PE2, ERC-2012-StG_20111012
Summary The aim of the present proposal is to establish a research team developing and exploiting dualities arising in super-symmetric gauge theories, string theory and conformal field theories. These will also have many applications outside these fields. The overarching aims of the team will be: To develop established dualities into computational tools for physical quantities such as the S-matrix, correlation functions and partition functions. The construction of explicit examples of new dualities. To use such dualities to gain new insights into the mathematical structure of the theories involved.
The proposal brings together researchers with different areas of expertise: super-symmetric gauge theories, string theories, conformal field theories, integrable systems and special functions. We divide it into two strands:
Strand I. Deals with the AdS/CFT correspondence, scattering amplitudes and correlation functions. The main objectives are to compute scattering amplitudes of planar maximally-super symmetric Yang-Mills to all values of the coupling; extend these computations to the non-planar case; compute efficiently correlation functions in this theory.
Strand II. Deals with new and exciting correspondences between four dimensional super-symmetric theories and two dimensional conformal field theories. We aim to find more examples of 4d/2d correspondences and to develop the established ones (and new ones) into efficient computational tools which will be used, for instance, to compute correlation functions in 2d Conformal Toda theories and other CFT's and even physical quantities in theories that do not admit a Lagrangian description. Progress in the first part of this strand will be used to understand the elusive 6d (2,0) theory. Furthermore, we will actively look for common mathematical structures between strands I and II.
Summary
The aim of the present proposal is to establish a research team developing and exploiting dualities arising in super-symmetric gauge theories, string theory and conformal field theories. These will also have many applications outside these fields. The overarching aims of the team will be: To develop established dualities into computational tools for physical quantities such as the S-matrix, correlation functions and partition functions. The construction of explicit examples of new dualities. To use such dualities to gain new insights into the mathematical structure of the theories involved.
The proposal brings together researchers with different areas of expertise: super-symmetric gauge theories, string theories, conformal field theories, integrable systems and special functions. We divide it into two strands:
Strand I. Deals with the AdS/CFT correspondence, scattering amplitudes and correlation functions. The main objectives are to compute scattering amplitudes of planar maximally-super symmetric Yang-Mills to all values of the coupling; extend these computations to the non-planar case; compute efficiently correlation functions in this theory.
Strand II. Deals with new and exciting correspondences between four dimensional super-symmetric theories and two dimensional conformal field theories. We aim to find more examples of 4d/2d correspondences and to develop the established ones (and new ones) into efficient computational tools which will be used, for instance, to compute correlation functions in 2d Conformal Toda theories and other CFT's and even physical quantities in theories that do not admit a Lagrangian description. Progress in the first part of this strand will be used to understand the elusive 6d (2,0) theory. Furthermore, we will actively look for common mathematical structures between strands I and II.
Max ERC Funding
1 414 258 €
Duration
Start date: 2012-12-01, End date: 2017-11-30
Project acronym DYNACEUTICS
Project Remote control healing: Next generation mechano-nano-therapeutics
Researcher (PI) Alicia El Haj
Host Institution (HI) THE UNIVERSITY OF BIRMINGHAM
Call Details Advanced Grant (AdG), PE8, ERC-2017-ADG
Summary Imagine if doctors could heal patients via remote control. Following simple injections into regions of the body, they could activate internal cells by an external bandage. In this way, they could remotely control the ways tissue heal. This Advanced grant sets out to understand, design and develop the mechano-nano-magnetic platform that will underpin this therapeutic strategy for the future – DYNACEUTICS.
Key receptors have been identified such as ion channels, integrins and growth factors which respond to mechanical cues on the membrane and activate downstream pathways. How do we ‘bottle’ an agonist like a drug which can influence or regulate mechano-sensors on the membrane and can be controlled remotely? This project tackles this complex interdisciplinary question through breakthrough nanotechnologies. We aim to expand and develop a platform technology using magnetic particle tagging which will allow us to direct cells for therapeutic purposes.
Specifically, we aim
• to identify mechano-receptor binding sites on stem and mature cells which will enable remote activation of signalling pathways via magnetic fields,
• to design and test magnetic particles with tailored tagging strategies using single cell through 3D human organoid models to in vivo disease models,
• to tailor and design external remote control devices
• to create clinically relevant treatment modalities for remote control healing.
This proposal presents a unique opportunity to launch a new dynamic treatment platform, DYNACEUTICS, which we propose will extend the therapeutic horizon and provide a new form of remote controlled healing.
Summary
Imagine if doctors could heal patients via remote control. Following simple injections into regions of the body, they could activate internal cells by an external bandage. In this way, they could remotely control the ways tissue heal. This Advanced grant sets out to understand, design and develop the mechano-nano-magnetic platform that will underpin this therapeutic strategy for the future – DYNACEUTICS.
Key receptors have been identified such as ion channels, integrins and growth factors which respond to mechanical cues on the membrane and activate downstream pathways. How do we ‘bottle’ an agonist like a drug which can influence or regulate mechano-sensors on the membrane and can be controlled remotely? This project tackles this complex interdisciplinary question through breakthrough nanotechnologies. We aim to expand and develop a platform technology using magnetic particle tagging which will allow us to direct cells for therapeutic purposes.
Specifically, we aim
• to identify mechano-receptor binding sites on stem and mature cells which will enable remote activation of signalling pathways via magnetic fields,
• to design and test magnetic particles with tailored tagging strategies using single cell through 3D human organoid models to in vivo disease models,
• to tailor and design external remote control devices
• to create clinically relevant treatment modalities for remote control healing.
This proposal presents a unique opportunity to launch a new dynamic treatment platform, DYNACEUTICS, which we propose will extend the therapeutic horizon and provide a new form of remote controlled healing.
Max ERC Funding
2 499 068 €
Duration
Start date: 2019-01-01, End date: 2023-12-31
Project acronym EARTH CORE STRUCTURE
Project Thermal and compositional state of the Earth's inner core from seismic free oscillations
Researcher (PI) Arwen Fedora Deuss
Host Institution (HI) THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Call Details Starting Grant (StG), PE8, ERC-2007-StG
Summary The core, comprising the innermost parts of the Earth, is one of the most dynamic regions of our planet. The inner core is solid, surrounded by a liquid iron alloy. Inner core solidification combined with motions in the fluid outer core drive the geodynamo which generates Earth's magnetic field. Solidification of the inner core also supplies some of the heat that drives mantle convection and subsequently plate tectonics at the surface of the Earth. The thermal and compositional structure of the inner core is thus key to understanding the inner workings of our planet. No direct samples can be taken of the core and our knowledge of the thermal and compositional state of the Earth's outer and inner core relies on seismology. Ray theoretical studies using short period body waves are the most commonly used seismological data; these have led to observations of a large range of anomalous structures in the Earth's inner core, including anistropy, layers and hemispherical variations. However, due to uneven station and earthquake distribution, the robustness and global distribution of these features is still controversial. Long period seismic free oscillations, on the other hand, are able to provide global constraints, but lack of appropriate theory has prevented more complicated structures from being studied using normal modes. Thus, many fundamental questions regarding the thermal history of the core and geodynamo remain unanswered. Here, I propose to develop a comprehensive seismic inner core model, employing fully-coupled normal mode theory for the first time and using data from large earthquakes such as the Sumatra-Andaman event of 26 December 2006. This will dramatically change our current ideas of structure in the inner core. Using a novel combination of fluid dynamics and mineral physics I will interpret the thermal and compositional structure found at the centre of our planet, which in turn are fundamental to understand its geodynamo and magnetic field.
Summary
The core, comprising the innermost parts of the Earth, is one of the most dynamic regions of our planet. The inner core is solid, surrounded by a liquid iron alloy. Inner core solidification combined with motions in the fluid outer core drive the geodynamo which generates Earth's magnetic field. Solidification of the inner core also supplies some of the heat that drives mantle convection and subsequently plate tectonics at the surface of the Earth. The thermal and compositional structure of the inner core is thus key to understanding the inner workings of our planet. No direct samples can be taken of the core and our knowledge of the thermal and compositional state of the Earth's outer and inner core relies on seismology. Ray theoretical studies using short period body waves are the most commonly used seismological data; these have led to observations of a large range of anomalous structures in the Earth's inner core, including anistropy, layers and hemispherical variations. However, due to uneven station and earthquake distribution, the robustness and global distribution of these features is still controversial. Long period seismic free oscillations, on the other hand, are able to provide global constraints, but lack of appropriate theory has prevented more complicated structures from being studied using normal modes. Thus, many fundamental questions regarding the thermal history of the core and geodynamo remain unanswered. Here, I propose to develop a comprehensive seismic inner core model, employing fully-coupled normal mode theory for the first time and using data from large earthquakes such as the Sumatra-Andaman event of 26 December 2006. This will dramatically change our current ideas of structure in the inner core. Using a novel combination of fluid dynamics and mineral physics I will interpret the thermal and compositional structure found at the centre of our planet, which in turn are fundamental to understand its geodynamo and magnetic field.
Max ERC Funding
1 202 744 €
Duration
Start date: 2008-10-01, End date: 2014-09-30
Project acronym eEDM
Project A laser-cooled molecular fountain to measure the electron EDM
Researcher (PI) Edward Allen Hinds
Host Institution (HI) IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Call Details Advanced Grant (AdG), PE2, ERC-2012-ADG_20120216
Summary I propose to build an instrument that cools YbF molecules to microK temperature using laser light, and throws them up as a fountain in free fall. This will be used to detect CP-violating elementary particle interactions that caused our universe to evolve an excess of matter over antimatter These interactions cause the charge distribution of the electron to be slightly non-spherical and it is this property, the permanent electric dipole moment (EDM), that the ultracold molecules will sense.
Laser cooling of any molecule is very new, with first results emerging from a few laboratories including mine. Developing a fountain of molecules will be a major advance in the state of the art. As well as being the key to the new EDM instrument, this will be important in its own right because ultracold molecules have major applications in chemistry, quantum information processing and metrology.
In the fountain, the electron spin of each molecule will be polarized. On applying a perpendicular electric field, the spins will precess in proportion to the EDM. At present the (warm) YbF molecules in my lab precess for only 1ms. This gives us world-leading sensitivity, but has not been sufficient to detect the CP-violating forces being sought. The fountain however will achieve precession times of almost a second, giving over 1000x more rotation. The increase in sensitivity should reveal a clear EDM, providing information about the fundamental laws of physics, and the important CP-violating physics of the early universe, which is currently not understood.
By advancing the preparation of ultracold molecules, this project will address a key question in particle physics and cosmology: the nature of CP-violating physics beyond the standard model. The approach is radically different from standard accelerator physics and complements it. The sensitivity is sufficient to detect some proposed new forces that are beyond the reach of any current collider experiment.
Summary
I propose to build an instrument that cools YbF molecules to microK temperature using laser light, and throws them up as a fountain in free fall. This will be used to detect CP-violating elementary particle interactions that caused our universe to evolve an excess of matter over antimatter These interactions cause the charge distribution of the electron to be slightly non-spherical and it is this property, the permanent electric dipole moment (EDM), that the ultracold molecules will sense.
Laser cooling of any molecule is very new, with first results emerging from a few laboratories including mine. Developing a fountain of molecules will be a major advance in the state of the art. As well as being the key to the new EDM instrument, this will be important in its own right because ultracold molecules have major applications in chemistry, quantum information processing and metrology.
In the fountain, the electron spin of each molecule will be polarized. On applying a perpendicular electric field, the spins will precess in proportion to the EDM. At present the (warm) YbF molecules in my lab precess for only 1ms. This gives us world-leading sensitivity, but has not been sufficient to detect the CP-violating forces being sought. The fountain however will achieve precession times of almost a second, giving over 1000x more rotation. The increase in sensitivity should reveal a clear EDM, providing information about the fundamental laws of physics, and the important CP-violating physics of the early universe, which is currently not understood.
By advancing the preparation of ultracold molecules, this project will address a key question in particle physics and cosmology: the nature of CP-violating physics beyond the standard model. The approach is radically different from standard accelerator physics and complements it. The sensitivity is sufficient to detect some proposed new forces that are beyond the reach of any current collider experiment.
Max ERC Funding
2 409 629 €
Duration
Start date: 2013-02-01, End date: 2018-01-31
Project acronym EMATTER
Project New materials for energy production and sustainable energy use
Researcher (PI) Stoyan Smoukov
Host Institution (HI) THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Call Details Starting Grant (StG), PE8, ERC-2011-StG_20101014
Summary The proposed research is in the field of nanofiber materials, focusing on the development of functional nanofibers for the complementary purposes of energy production and sustainable energy use. Significant opportunities exist in these areas, stemming from the development of several methods in the last decade for higher capacity nanofiber production, as well as the strategic need to find alternatives to current production of energy and its uses. Nanofibers are expected to bring revolutionary advances to these and many other fields of science and technology, including catalysis, filtration, protein separations, tissue engineering, and flexible electronics. We will work on creating such materials with potential applications in multi-exciton photovoltaics and catalysis for energy production. For sustainable energy use, we will develop bioinspired responsive materials and architectures, which would store energy, release it on demand, and act as life-like, efficient, and autonomous entities. Fundamental questions we will address in the research include: How do we tailor semiconductor band structures, as well as achieve nanoscale morphologies for efficient dissociation of photogenerated excitons? Can we develop general predictive rules for the conditions needed to fabricate nanofibers from any polymer solution by liquid shear processing? Can the molecular crystallinity and porosity be controlled in the fibers? What are the simplest life-like, autonomous devices that could be made with synthetic materials?
This work will include extensive solution-based synthesis, processing, structural and chemical characterization (by optical and electron microscopy, small angle X-rays), physical property measurements (mechanical, optical, electronic), device fabrication and assembly, and computer simulations. Most of the facilities needed for the research are available in Cambridge, and some will be arranged for through external collaborations.
Summary
The proposed research is in the field of nanofiber materials, focusing on the development of functional nanofibers for the complementary purposes of energy production and sustainable energy use. Significant opportunities exist in these areas, stemming from the development of several methods in the last decade for higher capacity nanofiber production, as well as the strategic need to find alternatives to current production of energy and its uses. Nanofibers are expected to bring revolutionary advances to these and many other fields of science and technology, including catalysis, filtration, protein separations, tissue engineering, and flexible electronics. We will work on creating such materials with potential applications in multi-exciton photovoltaics and catalysis for energy production. For sustainable energy use, we will develop bioinspired responsive materials and architectures, which would store energy, release it on demand, and act as life-like, efficient, and autonomous entities. Fundamental questions we will address in the research include: How do we tailor semiconductor band structures, as well as achieve nanoscale morphologies for efficient dissociation of photogenerated excitons? Can we develop general predictive rules for the conditions needed to fabricate nanofibers from any polymer solution by liquid shear processing? Can the molecular crystallinity and porosity be controlled in the fibers? What are the simplest life-like, autonomous devices that could be made with synthetic materials?
This work will include extensive solution-based synthesis, processing, structural and chemical characterization (by optical and electron microscopy, small angle X-rays), physical property measurements (mechanical, optical, electronic), device fabrication and assembly, and computer simulations. Most of the facilities needed for the research are available in Cambridge, and some will be arranged for through external collaborations.
Max ERC Funding
1 963 835 €
Duration
Start date: 2012-02-01, End date: 2018-01-31
Project acronym ENIGMA
Project ENIneering MAterial properties with advanced laser direct writing
Researcher (PI) Peter KAZANSKY
Host Institution (HI) UNIVERSITY OF SOUTHAMPTON
Call Details Advanced Grant (AdG), PE8, ERC-2017-ADG
Summary Ultrafast laser material processing is approaching its limits in terms of ability to produce innovative materials with
compositional and structural consistency. The main idea of this project is to remove barriers to product development and go
beyond state-of-the-art by applying tailored and few-cycle laser pulses (FCLPs) for engineering of materials.
In this project I will investigate the interaction between intense ultra-short light pulses and matter at or below the wavelength
scale reaching states of matter found only deep planetary conditions.A key goal of the project is to exploit these extreme
conditions for synthesising unique material phases with on-demand optical and electronic properties, and progress photonic
devices with utilizing FCLP advantages: control over the bond scissoring density; efficient and highly localized energy
deposition; seeding of self-organized nanostructures; manipulation of spatio-temporal coupling.
Currently, a key limitation is plasma scattering that diminishes the performance of engineered materials. The question I will
address is whether control of ultra-short pulses can lead to ways around this limitation. The control of self-organization
process will revolutionize the field of data storage by achieving record high 100 TB/cm3 densities, high writing speed and
practically unlimited lifetime. I will radically improve the performance of printed flat optics with perfected nanostructures
engineered from nano- to macro-scale and capable of replacing conventional optics significantly advancing photonic devices
used in high-resolution microscopy, consumer electronics, and high-power laser applications. I envisage obtaining exotic
material phases such as metallic phases of silicon and tailored metallic nanoparticles in silicate glass. Hence this project will
push the frontiers of laser material processing to unprecedented precision and will develop novel family of devices that will
feed into the future of optics, electronics and computing
Summary
Ultrafast laser material processing is approaching its limits in terms of ability to produce innovative materials with
compositional and structural consistency. The main idea of this project is to remove barriers to product development and go
beyond state-of-the-art by applying tailored and few-cycle laser pulses (FCLPs) for engineering of materials.
In this project I will investigate the interaction between intense ultra-short light pulses and matter at or below the wavelength
scale reaching states of matter found only deep planetary conditions.A key goal of the project is to exploit these extreme
conditions for synthesising unique material phases with on-demand optical and electronic properties, and progress photonic
devices with utilizing FCLP advantages: control over the bond scissoring density; efficient and highly localized energy
deposition; seeding of self-organized nanostructures; manipulation of spatio-temporal coupling.
Currently, a key limitation is plasma scattering that diminishes the performance of engineered materials. The question I will
address is whether control of ultra-short pulses can lead to ways around this limitation. The control of self-organization
process will revolutionize the field of data storage by achieving record high 100 TB/cm3 densities, high writing speed and
practically unlimited lifetime. I will radically improve the performance of printed flat optics with perfected nanostructures
engineered from nano- to macro-scale and capable of replacing conventional optics significantly advancing photonic devices
used in high-resolution microscopy, consumer electronics, and high-power laser applications. I envisage obtaining exotic
material phases such as metallic phases of silicon and tailored metallic nanoparticles in silicate glass. Hence this project will
push the frontiers of laser material processing to unprecedented precision and will develop novel family of devices that will
feed into the future of optics, electronics and computing
Max ERC Funding
2 499 957 €
Duration
Start date: 2019-01-01, End date: 2023-12-31
Project acronym EPIC
Project Energy transfer Processes at gas/wall Interfaces under extreme Conditions
Researcher (PI) Brian PETERSON
Host Institution (HI) THE UNIVERSITY OF EDINBURGH
Call Details Starting Grant (StG), PE8, ERC-2017-STG
Summary In the future, high-efficiency (low CO2) vehicles will be powered in part by reinvented internal combustion (IC) engines that are “downsized” and operate with new combustion modes. These engine concepts are subject to problems such as increased transient heat transfer and flame quenching in small passages. Near-wall transient heat transfer is not well-understood in engine environments; the gas is not constant in pressure, temperature, or velocity such that physical processes quickly digress from established theory. EPIC is uniquely placed to address these problems. A novel constant-volume chamber, offering realistic engine passages but with optical access, and which emulates the pressure/temperature time curve of a real engine, will be developed. This chamber will make it possible to measure the highly transient and highly variable processes at the gas/wall interface (including a highly dynamic flame front) for single- and two-wall passages. Measurements will be made using a suite of advanced laser diagnostics; a novel aspect of the proposed work as they have not been used in combination to study such a problem before. Hybrid fs/ps rotational coherent Raman (i.e. CARS) in a line format will provide transient gas temperature and species profiles normal to the wall surface in high-risk/high-gain packages. PIV/PTV measurements will further elucidate flow dynamics at the surface. Planar OH-LIF will help interpret CARS measurements and provide necessary details of flame transport and quenching. As the flame approaches the surface, phosphor thermometry will measure wall temperature and heat flux to elucidate the highly dynamic inter-coupling between flame and wall. EPIC will provide substantial breakthroughs in knowledge by measuring unsteady boundary layer development and understanding its influence on flame quenching for single- and two-wall surfaces. As such, EPIC will provide the fundamental knowledge that supports cleaner combustion technology for the future.
Summary
In the future, high-efficiency (low CO2) vehicles will be powered in part by reinvented internal combustion (IC) engines that are “downsized” and operate with new combustion modes. These engine concepts are subject to problems such as increased transient heat transfer and flame quenching in small passages. Near-wall transient heat transfer is not well-understood in engine environments; the gas is not constant in pressure, temperature, or velocity such that physical processes quickly digress from established theory. EPIC is uniquely placed to address these problems. A novel constant-volume chamber, offering realistic engine passages but with optical access, and which emulates the pressure/temperature time curve of a real engine, will be developed. This chamber will make it possible to measure the highly transient and highly variable processes at the gas/wall interface (including a highly dynamic flame front) for single- and two-wall passages. Measurements will be made using a suite of advanced laser diagnostics; a novel aspect of the proposed work as they have not been used in combination to study such a problem before. Hybrid fs/ps rotational coherent Raman (i.e. CARS) in a line format will provide transient gas temperature and species profiles normal to the wall surface in high-risk/high-gain packages. PIV/PTV measurements will further elucidate flow dynamics at the surface. Planar OH-LIF will help interpret CARS measurements and provide necessary details of flame transport and quenching. As the flame approaches the surface, phosphor thermometry will measure wall temperature and heat flux to elucidate the highly dynamic inter-coupling between flame and wall. EPIC will provide substantial breakthroughs in knowledge by measuring unsteady boundary layer development and understanding its influence on flame quenching for single- and two-wall surfaces. As such, EPIC will provide the fundamental knowledge that supports cleaner combustion technology for the future.
Max ERC Funding
1 499 351 €
Duration
Start date: 2017-12-01, End date: 2022-11-30
Project acronym ERQUAF
Project Entanglement and Renormalisation for Quantum Fields
Researcher (PI) Jutho Jan J HAEGEMAN
Host Institution (HI) UNIVERSITEIT GENT
Call Details Starting Grant (StG), PE2, ERC-2016-STG
Summary Over the past fifteen years, the paradigm of quantum entanglement has revolutionised the understanding of strongly correlated lattice systems. Entanglement and closely related concepts originating from quantum information theory are optimally suited for quantifying and characterising quantum correlations and have therefore proven instrumental for the classification of the exotic phases discovered in condensed quantum matter. One groundbreaking development originating from this research is a novel class of variational many body wave functions known as tensor network states. Their explicit local structure and unique entanglement features make them very flexible and extremely powerful both as a numerical simulation method and as a theoretical tool.
The goal of this proposal is to lift this “entanglement methodology” into the realm of quantum field theory. In high energy physics, the widespread interest in entanglement has only been triggered recently due to the intriguing connections between entanglement and the structure of spacetime that arise in black hole physics and quantum gravity. During the past few years, direct continuum limits of various tensor network ansätze have been formulated. However, the application thereof is largely unexplored territory and holds promising potential. This proposal formulates several advancements and developments for the theoretical and computational study of continuous quantum systems, gauge theories and exotic quantum phases, but also for establishing the intricate relation between entanglement, renormalisation and geometry in the context of the holographic principle. Ultimately, these developments will radically alter the way in which to approach some of the most challenging questions in physics, ranging from the simulation of cold atom systems to non-equilibrium or high-density situations in quantum chromodynamics and the standard model.
Summary
Over the past fifteen years, the paradigm of quantum entanglement has revolutionised the understanding of strongly correlated lattice systems. Entanglement and closely related concepts originating from quantum information theory are optimally suited for quantifying and characterising quantum correlations and have therefore proven instrumental for the classification of the exotic phases discovered in condensed quantum matter. One groundbreaking development originating from this research is a novel class of variational many body wave functions known as tensor network states. Their explicit local structure and unique entanglement features make them very flexible and extremely powerful both as a numerical simulation method and as a theoretical tool.
The goal of this proposal is to lift this “entanglement methodology” into the realm of quantum field theory. In high energy physics, the widespread interest in entanglement has only been triggered recently due to the intriguing connections between entanglement and the structure of spacetime that arise in black hole physics and quantum gravity. During the past few years, direct continuum limits of various tensor network ansätze have been formulated. However, the application thereof is largely unexplored territory and holds promising potential. This proposal formulates several advancements and developments for the theoretical and computational study of continuous quantum systems, gauge theories and exotic quantum phases, but also for establishing the intricate relation between entanglement, renormalisation and geometry in the context of the holographic principle. Ultimately, these developments will radically alter the way in which to approach some of the most challenging questions in physics, ranging from the simulation of cold atom systems to non-equilibrium or high-density situations in quantum chromodynamics and the standard model.
Max ERC Funding
1 499 375 €
Duration
Start date: 2017-02-01, End date: 2022-01-31
Project acronym EXACTYMER
Project ADVANCED NANOMEMBRANES FOR EXACT POLYMER PRODUCTION
Researcher (PI) Andrew LIVINGSTON
Host Institution (HI) IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Call Details Advanced Grant (AdG), PE8, ERC-2017-ADG
Summary The production of synthetic polymers with precisely defined monomer sequences – exact polymers, which I call “exactymers” – is highly challenging. Iterative synthesis, in which specific monomers are added one-at-a-time to the end of a growing polymer chain, affords exquisite control over the final sequence, but requires accurate purification of the growing polymer with each and every cycle. EXACTYMER will create new super-stable, ultra-selective nanomembranes, with high permeances, enabling rapid, repeated purifications, which will transform exactymer fabrication. Multiple growing polymer chains will be attached to a central hub molecule to create a macromolecular homostar with enhanced molecular size, promoting accurate separation of the growing exactymer from reaction debris via nanomembrane processing. Automation and engineering will enable rapid, accurate and precise cycles of exactymer chain growth. EXACTYMER objectives will be achieved through curiosity-driven research into (1) the creation of nanomembranes with exquisite molecular selectivity between growing homostars and monomer plus reaction debris; (2) advancing the chemistry of iterative synthesis by creating strategies for step-wise growth of polyethers, polysiloxanes, and polyesters, and side chain functionalised monomers of these species; (3) combining iterative chemistry and nanomembranes together in an automated homostar nanofiltration platform, and; (4) exploring the use of exactymers in healthcare, nanotechnology and information storage. EXACTYMER will undertake pioneering research at the boundaries of membrane technology, polymer synthesis, process engineering and nanotechnology. The most profound anticipated outcome is a new capability to produce synthetic polymers, over 20 monomers in length, with exactly defined monomer sequences to an unprecedented accuracy, at multi-gram scale. New scientific insights will derive from the properties and performances of these newly accessible molecules.
Summary
The production of synthetic polymers with precisely defined monomer sequences – exact polymers, which I call “exactymers” – is highly challenging. Iterative synthesis, in which specific monomers are added one-at-a-time to the end of a growing polymer chain, affords exquisite control over the final sequence, but requires accurate purification of the growing polymer with each and every cycle. EXACTYMER will create new super-stable, ultra-selective nanomembranes, with high permeances, enabling rapid, repeated purifications, which will transform exactymer fabrication. Multiple growing polymer chains will be attached to a central hub molecule to create a macromolecular homostar with enhanced molecular size, promoting accurate separation of the growing exactymer from reaction debris via nanomembrane processing. Automation and engineering will enable rapid, accurate and precise cycles of exactymer chain growth. EXACTYMER objectives will be achieved through curiosity-driven research into (1) the creation of nanomembranes with exquisite molecular selectivity between growing homostars and monomer plus reaction debris; (2) advancing the chemistry of iterative synthesis by creating strategies for step-wise growth of polyethers, polysiloxanes, and polyesters, and side chain functionalised monomers of these species; (3) combining iterative chemistry and nanomembranes together in an automated homostar nanofiltration platform, and; (4) exploring the use of exactymers in healthcare, nanotechnology and information storage. EXACTYMER will undertake pioneering research at the boundaries of membrane technology, polymer synthesis, process engineering and nanotechnology. The most profound anticipated outcome is a new capability to produce synthetic polymers, over 20 monomers in length, with exactly defined monomer sequences to an unprecedented accuracy, at multi-gram scale. New scientific insights will derive from the properties and performances of these newly accessible molecules.
Max ERC Funding
2 499 814 €
Duration
Start date: 2018-07-01, End date: 2023-06-30
Project acronym ExclusiveHiggs
Project Search for New Physics in First and Second Generation Quark Yukawa Couplings through Rare Exclusive Decays of the Observed Higgs Boson
Researcher (PI) Konstantinos NIKOLOPOULOS
Host Institution (HI) THE UNIVERSITY OF BIRMINGHAM
Call Details Starting Grant (StG), PE2, ERC-2016-STG
Summary Following the discovery of a Higgs boson with a mass of about 125 GeV, a detailed set of property measurements has confirmed that it plays a central role in the spontaneous breaking of the electroweak symmetry.
Nevertheless, its role in the generation of fermion mass, in particular of the first and second generation, is still unclear. In the Standard Model (SM) this is implemented in an ad hoc manner through Yukawa interactions, and many beyond-the-SM theories offer rich phenomenology and exciting prospects for the discovery of New Physics in this sector.
This project will attack - for the first time - in a systematic and comprehensive way the experimentally most unconstrained sector of the SM: the couplings of the light-quarks (up, down, charm and strange) to the Higgs boson, including possible flavour-violating interactions. The rare exclusive Higgs boson decays to a meson and a photon or Z boson, which is a novel and unique approach, will be searched for with the ATLAS detector at the CERN Large Hadron Collider (LHC). At the same time, an extensive set of measurements of analogous rare exclusive decays of the W and Z bosons will be performed, further enhancing the scientific value of the proposed research programme.
The expected branching ratio sensitivity of 10^{-6} for the Higgs boson decays, and 10^{-9} for the W and Z boson decays will probe viable New Physics models, and in several cases will reach and surpass the SM predictions. This project will lead to a profound extension of the ATLAS and LHC physics output, going beyond what was previously considered possible. It will open a new line of research in the Higgs sector, providing relevant input to many different areas of frontier research, including particle cosmology and planning for possible future particle physics facilities.
Summary
Following the discovery of a Higgs boson with a mass of about 125 GeV, a detailed set of property measurements has confirmed that it plays a central role in the spontaneous breaking of the electroweak symmetry.
Nevertheless, its role in the generation of fermion mass, in particular of the first and second generation, is still unclear. In the Standard Model (SM) this is implemented in an ad hoc manner through Yukawa interactions, and many beyond-the-SM theories offer rich phenomenology and exciting prospects for the discovery of New Physics in this sector.
This project will attack - for the first time - in a systematic and comprehensive way the experimentally most unconstrained sector of the SM: the couplings of the light-quarks (up, down, charm and strange) to the Higgs boson, including possible flavour-violating interactions. The rare exclusive Higgs boson decays to a meson and a photon or Z boson, which is a novel and unique approach, will be searched for with the ATLAS detector at the CERN Large Hadron Collider (LHC). At the same time, an extensive set of measurements of analogous rare exclusive decays of the W and Z bosons will be performed, further enhancing the scientific value of the proposed research programme.
The expected branching ratio sensitivity of 10^{-6} for the Higgs boson decays, and 10^{-9} for the W and Z boson decays will probe viable New Physics models, and in several cases will reach and surpass the SM predictions. This project will lead to a profound extension of the ATLAS and LHC physics output, going beyond what was previously considered possible. It will open a new line of research in the Higgs sector, providing relevant input to many different areas of frontier research, including particle cosmology and planning for possible future particle physics facilities.
Max ERC Funding
1 499 945 €
Duration
Start date: 2017-03-01, End date: 2022-02-28
Project acronym ExtendGlass
Project Extending the range of the glassy state: Exploring structure and property limits in metallic glasses
Researcher (PI) Alan Lindsay GREER
Host Institution (HI) THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Call Details Advanced Grant (AdG), PE8, ERC-2015-AdG
Summary Metallic glasses (MGs), among the most actively studied metallic materials, have attractive mechanical properties (high elastic limit) but show work-softening and lack ductility. Recent work suggests the as-cast state of MGs can be much altered by thermomechanical treatments: rejuvenation (to higher energy) offers improved plasticity (perhaps even desirable work-hardening); relaxation (to lower energy) offers access to ultrastable states. Work of the PI has just shown that even simple thermal cycling can induce rejuvenation comparable with that from heavy plastic deformation, while elastic stress cycling can accelerate annealing. The research aims to extend the range of glassy states and to explore the consequences of unusual states, particularly for mechanical properties and for phase stability/crystallization. One possible limit to rejuvenation is the onset of fast crystallization. This regime will be studied for its relevance to crystallization of melts of low glass-forming ability, of interest to fill a gap in existing crystal-growth theory and for application in phase-change memory. Nine work-packages address these and further issues: exploitation of inhomogeneity in MGs to improve properties and enable processing, e.g. to permit stress relief without accompanying undesirable embrittlement; probing the maximum extent of anisotropy in MGs and the links between anisotropic structure and flow. Complementing the many mechanical and structural studies, molecular-dynamics simulations will be used to identify local events relating to rejuvenation/relaxation, to characterize (at atomic level) the anisotropy induced by anelastic strain and viscoplastic flow, to characterize the processes at the solid/liquid interface in pure-metal systems to understand crystal-growth mechanisms, especially why growth of ccp metals is so fast (and glass-forming ability very low). From preliminary results, it is expected that properties can be widened much beyond those of as-cast MGs.
Summary
Metallic glasses (MGs), among the most actively studied metallic materials, have attractive mechanical properties (high elastic limit) but show work-softening and lack ductility. Recent work suggests the as-cast state of MGs can be much altered by thermomechanical treatments: rejuvenation (to higher energy) offers improved plasticity (perhaps even desirable work-hardening); relaxation (to lower energy) offers access to ultrastable states. Work of the PI has just shown that even simple thermal cycling can induce rejuvenation comparable with that from heavy plastic deformation, while elastic stress cycling can accelerate annealing. The research aims to extend the range of glassy states and to explore the consequences of unusual states, particularly for mechanical properties and for phase stability/crystallization. One possible limit to rejuvenation is the onset of fast crystallization. This regime will be studied for its relevance to crystallization of melts of low glass-forming ability, of interest to fill a gap in existing crystal-growth theory and for application in phase-change memory. Nine work-packages address these and further issues: exploitation of inhomogeneity in MGs to improve properties and enable processing, e.g. to permit stress relief without accompanying undesirable embrittlement; probing the maximum extent of anisotropy in MGs and the links between anisotropic structure and flow. Complementing the many mechanical and structural studies, molecular-dynamics simulations will be used to identify local events relating to rejuvenation/relaxation, to characterize (at atomic level) the anisotropy induced by anelastic strain and viscoplastic flow, to characterize the processes at the solid/liquid interface in pure-metal systems to understand crystal-growth mechanisms, especially why growth of ccp metals is so fast (and glass-forming ability very low). From preliminary results, it is expected that properties can be widened much beyond those of as-cast MGs.
Max ERC Funding
2 434 090 €
Duration
Start date: 2016-10-01, End date: 2021-09-30
Project acronym ExtreFlow
Project Extreme deformation of structured fluids and interfaces. Exploiting ultrafast collapse and yielding phenomena for new processes and formulated products
Researcher (PI) Valeria Garbin
Host Institution (HI) IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Call Details Starting Grant (StG), PE8, ERC-2014-STG
Summary The increasing demand for environmentally friendly, healthier, and better performing formulated products means that the process industry needs more than ever predictive models of formulation performance for rapid, effective, and sustainable screening of new products. Processing flows and end use produce deformations that are extreme compared to what is accessible with existing experimental methods. As a consequence, the effects of extreme deformation are often overlooked without justification.
Extreme deformation of structured fluids and soft materials is an unexplored dynamic regime where unexpected phenomena may emerge. New flow-induced microstructures can arise due to periodic forcing that is much faster than the relaxation timescale of the system, leading to collective behaviors and large transient stresses.
The goal of this research is to introduce a radically innovative approach to explore and characterize the regime of extreme deformation of structured fluids and interfaces. By combining cutting-edge techniques including acoustofluidics, microfluidics, and high-speed imaging, I will perform pioneering high-precision measurements of macroscopic stresses and evolution of the microstructure. I will also explore strategies to exploit the phenomena emerging upon extreme deformation (collapse under ultrafast compression, yielding) for new processes and for adding new functionality to formulated products.
These experimental results, complemented by discrete particle simulations and continuum-scale modeling, will provide new insights that will lay the foundations of the new field of ultrafast soft matter. Ultimately the results of this research program will guide the development of predictive tools that can tackle the time scales of realistic flow conditions for applications to virtual screening of new formulations.
Summary
The increasing demand for environmentally friendly, healthier, and better performing formulated products means that the process industry needs more than ever predictive models of formulation performance for rapid, effective, and sustainable screening of new products. Processing flows and end use produce deformations that are extreme compared to what is accessible with existing experimental methods. As a consequence, the effects of extreme deformation are often overlooked without justification.
Extreme deformation of structured fluids and soft materials is an unexplored dynamic regime where unexpected phenomena may emerge. New flow-induced microstructures can arise due to periodic forcing that is much faster than the relaxation timescale of the system, leading to collective behaviors and large transient stresses.
The goal of this research is to introduce a radically innovative approach to explore and characterize the regime of extreme deformation of structured fluids and interfaces. By combining cutting-edge techniques including acoustofluidics, microfluidics, and high-speed imaging, I will perform pioneering high-precision measurements of macroscopic stresses and evolution of the microstructure. I will also explore strategies to exploit the phenomena emerging upon extreme deformation (collapse under ultrafast compression, yielding) for new processes and for adding new functionality to formulated products.
These experimental results, complemented by discrete particle simulations and continuum-scale modeling, will provide new insights that will lay the foundations of the new field of ultrafast soft matter. Ultimately the results of this research program will guide the development of predictive tools that can tackle the time scales of realistic flow conditions for applications to virtual screening of new formulations.
Max ERC Funding
1 499 186 €
Duration
Start date: 2015-05-01, End date: 2020-04-30
Project acronym FERMILATT
Project Single-atom-resolved detection and manipulation of strongly correlated fermions in an optical lattice
Researcher (PI) Stefan Kuhr
Host Institution (HI) UNIVERSITY OF STRATHCLYDE
Call Details Starting Grant (StG), PE2, ERC-2011-StG_20101014
Summary I propose to realize single-atom- and spin-resolved in-situ imaging of strongly correlated fermions in an optical lattice. Whereas very recently strongly correlated bosonic systems could be imaged in an optical lattice at the single atom level, an experimental proof of single-site-resolved detection of fermions is still lacking. My project will allow to fully exploit the potential of ultracold atoms as a quantum simulator, especially for the Fermi-Hubbard model, which is a key model in condensed matter physics.
Gaining access to the in-trap atom distribution of the fermionic 40-potassium with single-atom and single-site resolution will allow for a new generation of experiments in the field. Direct observation of individual atoms and analysis of their quantum states and their spatial order in the lattice, including individual defects, are then possible. I will use this novel detection method to characterize, e.g., temperature or entropy distribution of the quantum phases such as fermionic Mott insulators, Band insulators or metallic phases.
Together with the possibility of local spin manipulations, I will investigate the effect of local perturbations on the system by spatially resolving the ensuing dynamical in-trap evolution. In this way, propagation and healing of artificially created defects can be studied. Local scale density modulations such as Friedel and Wigner oscillations of one-dimensional systems with hard boundaries will become observable. The local manipulation of the trapped atoms will be the key to implement novel cooling schemes that can remove regions of high entropy from the system. In this way much colder temperatures can be realized, where antiferromagnetic ordering is setting in. In a harmonic trap, these magnetically ordered phases are predicted to form ring-like structures, which can be ideally characterized by my novel spin-sensitive in-situ imaging techniques.
Summary
I propose to realize single-atom- and spin-resolved in-situ imaging of strongly correlated fermions in an optical lattice. Whereas very recently strongly correlated bosonic systems could be imaged in an optical lattice at the single atom level, an experimental proof of single-site-resolved detection of fermions is still lacking. My project will allow to fully exploit the potential of ultracold atoms as a quantum simulator, especially for the Fermi-Hubbard model, which is a key model in condensed matter physics.
Gaining access to the in-trap atom distribution of the fermionic 40-potassium with single-atom and single-site resolution will allow for a new generation of experiments in the field. Direct observation of individual atoms and analysis of their quantum states and their spatial order in the lattice, including individual defects, are then possible. I will use this novel detection method to characterize, e.g., temperature or entropy distribution of the quantum phases such as fermionic Mott insulators, Band insulators or metallic phases.
Together with the possibility of local spin manipulations, I will investigate the effect of local perturbations on the system by spatially resolving the ensuing dynamical in-trap evolution. In this way, propagation and healing of artificially created defects can be studied. Local scale density modulations such as Friedel and Wigner oscillations of one-dimensional systems with hard boundaries will become observable. The local manipulation of the trapped atoms will be the key to implement novel cooling schemes that can remove regions of high entropy from the system. In this way much colder temperatures can be realized, where antiferromagnetic ordering is setting in. In a harmonic trap, these magnetically ordered phases are predicted to form ring-like structures, which can be ideally characterized by my novel spin-sensitive in-situ imaging techniques.
Max ERC Funding
1 392 800 €
Duration
Start date: 2011-10-01, End date: 2016-09-30
Project acronym FLEET
Project Flying Electromagnetic Toroids
Researcher (PI) Nikolay ZHELUDEV
Host Institution (HI) UNIVERSITY OF SOUTHAMPTON
Call Details Advanced Grant (AdG), PE2, ERC-2017-ADG
Summary In this project I will study the generation, detection, and interaction with matter of Flying Toroids, a new type of light pulses never experimentally studied before. This represents an exciting opportunity to advance optics and electromagnetism in a radically new direction since Hertz, Marconi, Popov and Tesla developed technology for generating, detecting, and communicating with transverse electromagnetic waves.
Conventional transverse electromagnetic waves propagate in free-space with the electric and magnetic field vectors perpendicular to the wave propagation direction, forming the famous triad. Theoretical analysis of recent years has shown that another, very different type of waves exists, which propagate at the speed of light, but only occur as short bursts of electromagnetic energy in the form of Flying Toroids. Flying Toroids are inseparable solutions of Maxwell equations with a unique, doughnut-like configuration of the electric and magnetic fields. Flying Toroids interact with matter in unique ways, drastically different from that of conventional electromagnetic pulses.
In a broader context, the electrodynamics of Flying Toroids is an exciting emerging field of optical science linked to intriguing recent developments in physics such as toroidal dipoles and anapoles, and, due to their topology, to Majorana fermions and skyrmions.
Building on my recent proof-of-principle demonstration of Flying Toroid generation through conversion of few-cycle conventional transverse light pulses in artificial photonic nanostructures, my goal for this project is to experimentally study and understand the fundamental properties of Flying Toroids and their interaction with matter at optical frequencies, and to assess their potential for developing new technologies. In my vision this project can lead to spectacular new opportunities for spectroscopic and light-enabled applications, and will impact on other branches of science, from astronomy to solid-state physics.
Summary
In this project I will study the generation, detection, and interaction with matter of Flying Toroids, a new type of light pulses never experimentally studied before. This represents an exciting opportunity to advance optics and electromagnetism in a radically new direction since Hertz, Marconi, Popov and Tesla developed technology for generating, detecting, and communicating with transverse electromagnetic waves.
Conventional transverse electromagnetic waves propagate in free-space with the electric and magnetic field vectors perpendicular to the wave propagation direction, forming the famous triad. Theoretical analysis of recent years has shown that another, very different type of waves exists, which propagate at the speed of light, but only occur as short bursts of electromagnetic energy in the form of Flying Toroids. Flying Toroids are inseparable solutions of Maxwell equations with a unique, doughnut-like configuration of the electric and magnetic fields. Flying Toroids interact with matter in unique ways, drastically different from that of conventional electromagnetic pulses.
In a broader context, the electrodynamics of Flying Toroids is an exciting emerging field of optical science linked to intriguing recent developments in physics such as toroidal dipoles and anapoles, and, due to their topology, to Majorana fermions and skyrmions.
Building on my recent proof-of-principle demonstration of Flying Toroid generation through conversion of few-cycle conventional transverse light pulses in artificial photonic nanostructures, my goal for this project is to experimentally study and understand the fundamental properties of Flying Toroids and their interaction with matter at optical frequencies, and to assess their potential for developing new technologies. In my vision this project can lead to spectacular new opportunities for spectroscopic and light-enabled applications, and will impact on other branches of science, from astronomy to solid-state physics.
Max ERC Funding
2 570 198 €
Duration
Start date: 2018-10-01, End date: 2023-09-30
Project acronym FlexNanoFlow
Project Ultra-flexible nanostructures in flow: controlling folding, fracture and orientation in large-scale liquid processing of 2D nanomaterials
Researcher (PI) Lorenzo BOTTO
Host Institution (HI) QUEEN MARY UNIVERSITY OF LONDON
Call Details Starting Grant (StG), PE8, ERC-2016-STG
Summary 2D nanomaterials hold immense technological promise thanks to extraordinary intrinsic properties such as ultra-high conductivity, strength and unusual semiconducting properties. Our understanding of how these extremely thin and flexible objects are processed in flow is however inadequate, and this is hindering progress towards true market applications. When processed in liquid environments to make nanocomposites, conductive coatings and energy storage devices, 2D nanomaterials tend to fold and break owing to strong shear forces produced by the mechanical agitation of the liquid. This can lead to poorly-oriented, crumpled sheets of small lateral size and therefore of low intrinsic value. Orientation is also a major issue, as ultra-flexible materials are difficult to extend and align. In this project, I will develop nanoscale fluid-structure simulation techniques to capture with unprecedented resolution the unsteady deformation and fracture dynamics of single and multiple sheets in response to the complex hydrodynamic load produced by shearing flows. In addition, I will demonstrate via simulations new strategies to exploit capillary forces to structure 2D nanomaterials into 3D constructs of desired morphology. To guide the simulations and explore a wider parameter space than allowed in computations, I will develop conceptually new experiments on “scaled-up 2D nanomaterials”, macroscopic particles having the same dynamics as the nanoscopic ones. The simulations will include continuum treatments and atomistic details, and will be analysed within the theoretical framework of microhydrodynamics and non-linear solid mechanics. By uncovering the physical principles governing flow-induced deformation of 2D nanomaterials, this project will have a profound impact on our ability to produce and process 2D nanomaterials on large scales.
Summary
2D nanomaterials hold immense technological promise thanks to extraordinary intrinsic properties such as ultra-high conductivity, strength and unusual semiconducting properties. Our understanding of how these extremely thin and flexible objects are processed in flow is however inadequate, and this is hindering progress towards true market applications. When processed in liquid environments to make nanocomposites, conductive coatings and energy storage devices, 2D nanomaterials tend to fold and break owing to strong shear forces produced by the mechanical agitation of the liquid. This can lead to poorly-oriented, crumpled sheets of small lateral size and therefore of low intrinsic value. Orientation is also a major issue, as ultra-flexible materials are difficult to extend and align. In this project, I will develop nanoscale fluid-structure simulation techniques to capture with unprecedented resolution the unsteady deformation and fracture dynamics of single and multiple sheets in response to the complex hydrodynamic load produced by shearing flows. In addition, I will demonstrate via simulations new strategies to exploit capillary forces to structure 2D nanomaterials into 3D constructs of desired morphology. To guide the simulations and explore a wider parameter space than allowed in computations, I will develop conceptually new experiments on “scaled-up 2D nanomaterials”, macroscopic particles having the same dynamics as the nanoscopic ones. The simulations will include continuum treatments and atomistic details, and will be analysed within the theoretical framework of microhydrodynamics and non-linear solid mechanics. By uncovering the physical principles governing flow-induced deformation of 2D nanomaterials, this project will have a profound impact on our ability to produce and process 2D nanomaterials on large scales.
Max ERC Funding
1 453 779 €
Duration
Start date: 2017-04-01, End date: 2022-03-31
Project acronym FNPMLS
Project Fundamental nuclear properties measured with laser spectroscopy
Researcher (PI) Kieran Thomas Joseph Flanagan
Host Institution (HI) THE UNIVERSITY OF MANCHESTER
Call Details Consolidator Grant (CoG), PE2, ERC-2014-CoG
Summary The prime research theme of this project is the study of short-lived exotic nuclei with laser spectroscopy. Over the next 5 years my team will study the role of three-nucleon forces and their associated influence on nuclear structure and the limits of nuclear existence. This work will investigate the interplay between tensor and central forces and the associated effect on quantum shells in exotic nuclear systems. This proposal will study how the shape of the nucleus is modified at the limits of nuclear existence. We will use innovative laser spectroscopy methods to achieve these goals. The project will be carried out at the ISOLDE facility, CERN, which is the premier radioactive beam facility at the precision frontier. The proposed research activity closely matches the NuPECC (Nuclear Physics European Collaboration Committee) 2010 Long Range Plan. The wider scientific impact of this research will influence modelling explosive stellar processes and nuclear synthesis, understanding the structure of astrophysical compact-objects such as neutron stars and predicting regions of enhanced stability in the super heavy elements. The FNPMLS project will develop ultra-sensitive methodologies that set a new paradigm in laser spectroscopy. It builds on the cutting edge technology of collinear resonance ionization spectroscopy (CRIS) that I have developed during my STFC Advanced Fellowship. The CRIS technique combines the high resolution nature of collinear laser spectroscopy with the high sensitivity of resonance ionization spectroscopy. The research programme and investment outlined in this proposal will place my team in a unique and world leading position. This work will happen in advance of the next generation of radioactive beam facility such as SPIRAL2, FAIR and FRIB and will provide the essential ingredients for future fundamental questions.
Summary
The prime research theme of this project is the study of short-lived exotic nuclei with laser spectroscopy. Over the next 5 years my team will study the role of three-nucleon forces and their associated influence on nuclear structure and the limits of nuclear existence. This work will investigate the interplay between tensor and central forces and the associated effect on quantum shells in exotic nuclear systems. This proposal will study how the shape of the nucleus is modified at the limits of nuclear existence. We will use innovative laser spectroscopy methods to achieve these goals. The project will be carried out at the ISOLDE facility, CERN, which is the premier radioactive beam facility at the precision frontier. The proposed research activity closely matches the NuPECC (Nuclear Physics European Collaboration Committee) 2010 Long Range Plan. The wider scientific impact of this research will influence modelling explosive stellar processes and nuclear synthesis, understanding the structure of astrophysical compact-objects such as neutron stars and predicting regions of enhanced stability in the super heavy elements. The FNPMLS project will develop ultra-sensitive methodologies that set a new paradigm in laser spectroscopy. It builds on the cutting edge technology of collinear resonance ionization spectroscopy (CRIS) that I have developed during my STFC Advanced Fellowship. The CRIS technique combines the high resolution nature of collinear laser spectroscopy with the high sensitivity of resonance ionization spectroscopy. The research programme and investment outlined in this proposal will place my team in a unique and world leading position. This work will happen in advance of the next generation of radioactive beam facility such as SPIRAL2, FAIR and FRIB and will provide the essential ingredients for future fundamental questions.
Max ERC Funding
1 846 542 €
Duration
Start date: 2015-04-01, End date: 2020-03-31
Project acronym GADGET
Project Geometry and Anomalous Dynamic Growth of Elastic instabiliTies
Researcher (PI) Dominic Vella
Host Institution (HI) THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Call Details Starting Grant (StG), PE8, ERC-2014-STG
Summary Elastic instabilities are ubiquitous, from the wrinkles that form on skin to the ‘snap-through’ of an umbrella on a windy day. The complex patterns such instabilities make, and the great speed with which they develop, have led to a host of technological and scientific applications. However, recent experiments have revealed significant gaps in our theoretical understanding of such instabilities, particularly in the roles played by geometry and dynamics. I will establish a group to develop and validate a theoretical framework within which these results can be understood. Central to my approach is an appreciation of the crucial role of geometry in the pattern formation and dynamics of elastic instabilities.
As a starting point, I will consider the model problem of a pressurized elastic shell subject to a geometrically large deformation. This system develops either wrinkles or a stress-focusing instability depending on the internal pressure. As such, this is a natural paradigm with which to understand geometrical features of deformation relevant across length scales from deformed viruses to the subduction zones in Earth’s tectonic plates. My team will combine theoretical and computational approaches with tabletop experiments to determine a new set of shell deformations that are generically observed in contradiction of the classic ‘mirror buckling’. Understanding why these new shapes emerge will transform our perception of shell instabilities and provide new fundamental building blocks with which to model them. These ideas will also be used to transform our understanding of a number of other, previously mysterious, elastic instabilities of practical interest. Turning our focus to the dynamics of instabilities such as the snap-through of shells, we will show that accounting for geometry is again crucial. The new insight gained through this project will increase our ability to control elastic instabilities, benefitting a range of technological and scientific applications.
Summary
Elastic instabilities are ubiquitous, from the wrinkles that form on skin to the ‘snap-through’ of an umbrella on a windy day. The complex patterns such instabilities make, and the great speed with which they develop, have led to a host of technological and scientific applications. However, recent experiments have revealed significant gaps in our theoretical understanding of such instabilities, particularly in the roles played by geometry and dynamics. I will establish a group to develop and validate a theoretical framework within which these results can be understood. Central to my approach is an appreciation of the crucial role of geometry in the pattern formation and dynamics of elastic instabilities.
As a starting point, I will consider the model problem of a pressurized elastic shell subject to a geometrically large deformation. This system develops either wrinkles or a stress-focusing instability depending on the internal pressure. As such, this is a natural paradigm with which to understand geometrical features of deformation relevant across length scales from deformed viruses to the subduction zones in Earth’s tectonic plates. My team will combine theoretical and computational approaches with tabletop experiments to determine a new set of shell deformations that are generically observed in contradiction of the classic ‘mirror buckling’. Understanding why these new shapes emerge will transform our perception of shell instabilities and provide new fundamental building blocks with which to model them. These ideas will also be used to transform our understanding of a number of other, previously mysterious, elastic instabilities of practical interest. Turning our focus to the dynamics of instabilities such as the snap-through of shells, we will show that accounting for geometry is again crucial. The new insight gained through this project will increase our ability to control elastic instabilities, benefitting a range of technological and scientific applications.
Max ERC Funding
1 361 077 €
Duration
Start date: 2015-04-01, End date: 2020-03-31
Project acronym GAUGE-STRING
Project Gauge theory - String theory duality: maximally symmetric case and beyond
Researcher (PI) Arkadi Alexander Tseitline
Host Institution (HI) IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Call Details Advanced Grant (AdG), PE2, ERC-2011-ADG_20110209
Summary Quantum field theories with local gauge symmetry are building blocks of the modern theory of fundamental interactions between elementary particles. The basic example is Quantum Chromo Dynamics. There is strong evidence that QCD is the correct theory of strong interactions, but it has been difficult to use it to account for many hadronic phenomena which is due to large value of gauge coupling at low energies. Theoretical understanding of gauge theory dynamics at large values of coupling when one cannot use the Feynman diagram perturbation theory is a major problem of physics of strong interactions. Goals include analytic computation of mass spectrum of hadrons, etc. The general aim of this proposal is to develop new theoretical tools to describe strongly coupled gauge theories. Research in the last decade brought strong evidence that connection of gauge theories to string theory should be a key to solution of this problem. Gauge-string duality and, in particular, Anti deSitter / conformal field theory (AdS/CFT) correspondence is one of the most active directions of current work in theory of fundamental interactions. A remarkable progress was achieved towards quantitative understanding of this relation in the most symmetric case of maximally supersymmetric gauge theory in flat 4 dimensions dual to superstring theory in curved 10-dimensional AdS5 x S5 space. We propose a detailed study of this duality from the string theory side using world-sheet methods and hidden integrability of the maximally symmetric theory. The goal is to provide a first-principles proof of the duality for the spectrum of states and also to establish its validity at the level of correlation functions of conformal operators. We also plan to extend string-theoretic approach to gauge-string duality to less symmetric cases, corresponding, in particular, to certain non-supersymmetric conformal and n=1 supersymmetric non-conformal planar gauge theories.
Summary
Quantum field theories with local gauge symmetry are building blocks of the modern theory of fundamental interactions between elementary particles. The basic example is Quantum Chromo Dynamics. There is strong evidence that QCD is the correct theory of strong interactions, but it has been difficult to use it to account for many hadronic phenomena which is due to large value of gauge coupling at low energies. Theoretical understanding of gauge theory dynamics at large values of coupling when one cannot use the Feynman diagram perturbation theory is a major problem of physics of strong interactions. Goals include analytic computation of mass spectrum of hadrons, etc. The general aim of this proposal is to develop new theoretical tools to describe strongly coupled gauge theories. Research in the last decade brought strong evidence that connection of gauge theories to string theory should be a key to solution of this problem. Gauge-string duality and, in particular, Anti deSitter / conformal field theory (AdS/CFT) correspondence is one of the most active directions of current work in theory of fundamental interactions. A remarkable progress was achieved towards quantitative understanding of this relation in the most symmetric case of maximally supersymmetric gauge theory in flat 4 dimensions dual to superstring theory in curved 10-dimensional AdS5 x S5 space. We propose a detailed study of this duality from the string theory side using world-sheet methods and hidden integrability of the maximally symmetric theory. The goal is to provide a first-principles proof of the duality for the spectrum of states and also to establish its validity at the level of correlation functions of conformal operators. We also plan to extend string-theoretic approach to gauge-string duality to less symmetric cases, corresponding, in particular, to certain non-supersymmetric conformal and n=1 supersymmetric non-conformal planar gauge theories.
Max ERC Funding
1 679 584 €
Duration
Start date: 2012-02-01, End date: 2017-09-30
Project acronym Gauge-string duality
Project GAUGE-STRING DUALITY AND NON-EQUILIBRIUM PHYSICS
Researcher (PI) Andrei Starinets
Host Institution (HI) THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Call Details Starting Grant (StG), PE2, ERC-2012-StG_20111012
Summary The proposal is to study non-equilibrium states of strongly correlated quantum systems relevant for heavy ion and condensed matter physics by using existing and developing new methods of gauge-string duality (also know as holography or AdS/CFT correspondence). The gauge-string duality is a set of non-perturbative tools developed within string theory over the last fourteen years. These methods can be used independently of the final status of the string theory itself. Strongly coupled model systems at finite temperature and density are of great interest for they appear in many areas of physics including physics of heavy ion collisions and physics of trapped cold atoms. Gauge-string duality methods already proved very useful in supplying information about transport properties such as viscosity and spectral functions of thermal quantum field theories at strong coupling.
Specific goals of the proposal are divided into two sets, one including open problems in non-equilibrium systems accessible for study by the existing gauge/string duality techniques, and another involving more challenging problems requiring new holographic approaches. Problems of the first set include generalizing existing models of thermalization and isotropization, constructing simple model(s) describing the initial state of the quark-gluon plasma, exploring gravity backgrounds obtained by self-consistent top-down approach, studying theories with dual gravity backgrounds including full back-reaction. Problems of the second set involve holographic approach to turbulence and plasma instabilities, building holographic formalism for highly nonequilibrium processes and studying possible connection between holography and emergent gravity.
Summary
The proposal is to study non-equilibrium states of strongly correlated quantum systems relevant for heavy ion and condensed matter physics by using existing and developing new methods of gauge-string duality (also know as holography or AdS/CFT correspondence). The gauge-string duality is a set of non-perturbative tools developed within string theory over the last fourteen years. These methods can be used independently of the final status of the string theory itself. Strongly coupled model systems at finite temperature and density are of great interest for they appear in many areas of physics including physics of heavy ion collisions and physics of trapped cold atoms. Gauge-string duality methods already proved very useful in supplying information about transport properties such as viscosity and spectral functions of thermal quantum field theories at strong coupling.
Specific goals of the proposal are divided into two sets, one including open problems in non-equilibrium systems accessible for study by the existing gauge/string duality techniques, and another involving more challenging problems requiring new holographic approaches. Problems of the first set include generalizing existing models of thermalization and isotropization, constructing simple model(s) describing the initial state of the quark-gluon plasma, exploring gravity backgrounds obtained by self-consistent top-down approach, studying theories with dual gravity backgrounds including full back-reaction. Problems of the second set involve holographic approach to turbulence and plasma instabilities, building holographic formalism for highly nonequilibrium processes and studying possible connection between holography and emergent gravity.
Max ERC Funding
1 461 074 €
Duration
Start date: 2012-10-01, End date: 2017-09-30
Project acronym GAUGE/GRAVITY
Project The Gauge/Gravity Duality and Geometry in String Theory
Researcher (PI) Dario Martelli
Host Institution (HI) KING'S COLLEGE LONDON
Call Details Starting Grant (StG), PE2, ERC-2012-StG_20111012
Summary While the three sub-atomic forces are described by quantum mechanics, the fourth known force, gravity, is described by Einstein's theory of general relativity. These two very successful theories are incompatible, and understanding how to unify them in a single framework is an outstanding problem. String theory is the most prominent candidate for a unified theory of all forces of Nature. The most important conceptual breakthrough that emerged from string theory is Maldacena's conjectured duality between quantum field theory and gravity, known as AdS/CFT correspondence. This states that strings moving in anti-de Sitter (AdS) space-time, may equivalently be described by a type of quantum theory, called conformal field theory (CFT). More generally, it is a remarkable duality between quantum gauge theories in d dimensions and gravitational theories in (d+1)-dimensional space-times, implying that quantum theory and gravity, instead of being conflicting, are in fact equivalent. In this project I will aim at extending the gauge/gravity duality in multiple directions, which go beyond the current state of the art. In order to achieve a deeper understanding of the gauge/gravity duality I plan to develop novel mathematical approaches, that are likely to lead to new research directions in different areas of physics and mathematics. More specifically, the objectives of this project include: a systematic study of AdS backgrounds arising in string theory as a method for exploring CFTs; the development of geometric structures, such as generalised Sasaki-Einstein geometry, relevant for the AdS/CFT correspondence; a study of supersymmetric gauge theories on curved manifolds and of their gravity duals; a study of dualities between pairs of gauge theories and of related matrix models arising from localisation techniques; exploring the gauge/gravity duality as a tool for studying strongly interacting quantum critical phenomena, such as those that are of interest to real-world physics.
Summary
While the three sub-atomic forces are described by quantum mechanics, the fourth known force, gravity, is described by Einstein's theory of general relativity. These two very successful theories are incompatible, and understanding how to unify them in a single framework is an outstanding problem. String theory is the most prominent candidate for a unified theory of all forces of Nature. The most important conceptual breakthrough that emerged from string theory is Maldacena's conjectured duality between quantum field theory and gravity, known as AdS/CFT correspondence. This states that strings moving in anti-de Sitter (AdS) space-time, may equivalently be described by a type of quantum theory, called conformal field theory (CFT). More generally, it is a remarkable duality between quantum gauge theories in d dimensions and gravitational theories in (d+1)-dimensional space-times, implying that quantum theory and gravity, instead of being conflicting, are in fact equivalent. In this project I will aim at extending the gauge/gravity duality in multiple directions, which go beyond the current state of the art. In order to achieve a deeper understanding of the gauge/gravity duality I plan to develop novel mathematical approaches, that are likely to lead to new research directions in different areas of physics and mathematics. More specifically, the objectives of this project include: a systematic study of AdS backgrounds arising in string theory as a method for exploring CFTs; the development of geometric structures, such as generalised Sasaki-Einstein geometry, relevant for the AdS/CFT correspondence; a study of supersymmetric gauge theories on curved manifolds and of their gravity duals; a study of dualities between pairs of gauge theories and of related matrix models arising from localisation techniques; exploring the gauge/gravity duality as a tool for studying strongly interacting quantum critical phenomena, such as those that are of interest to real-world physics.
Max ERC Funding
1 253 098 €
Duration
Start date: 2013-01-01, End date: 2018-12-31
Project acronym GeopolyConc
Project Durability of geopolymers as 21st century concretes
Researcher (PI) John Lloyd Provis
Host Institution (HI) THE UNIVERSITY OF SHEFFIELD
Call Details Starting Grant (StG), PE8, ERC-2013-StG
Summary GeopolyConc will provide the necessary scientific basis for the prediction of the long-term durability performance of alkali-activated ‘geopolymer’ concretes. These materials can be synthesised from industrial by-products and widely-available natural resources, and provide the opportunity for a highly significant reduction in the environmental footprint of the global construction materials industry, as it expands to meet the infrastructure needs of 21st century society. Experimental and modelling approaches will be coupled to provide major advances in the state of the art in the science and engineering of geopolymer concretes. The key scientific focus areas will be: (a) the development of the first ever rigorous mathematical description of the factors influencing the transport properties of alkali-activated concretes, and (b) ground-breaking work in understanding and controlling the factors which lead to the onset of corrosion of steel reinforcing embedded in alkali-activated concretes. This project will generate confidence in geopolymer concrete durability, which is essential to the application of these materials in reducing EU and global CO2 emissions. The GeopolyConc project will also be integrated with leading multinational collaborative test programmes coordinated through a RILEM Technical Committee (TC DTA) which is chaired by the PI, providing a route to direct international utilisation of the project outcomes.
Summary
GeopolyConc will provide the necessary scientific basis for the prediction of the long-term durability performance of alkali-activated ‘geopolymer’ concretes. These materials can be synthesised from industrial by-products and widely-available natural resources, and provide the opportunity for a highly significant reduction in the environmental footprint of the global construction materials industry, as it expands to meet the infrastructure needs of 21st century society. Experimental and modelling approaches will be coupled to provide major advances in the state of the art in the science and engineering of geopolymer concretes. The key scientific focus areas will be: (a) the development of the first ever rigorous mathematical description of the factors influencing the transport properties of alkali-activated concretes, and (b) ground-breaking work in understanding and controlling the factors which lead to the onset of corrosion of steel reinforcing embedded in alkali-activated concretes. This project will generate confidence in geopolymer concrete durability, which is essential to the application of these materials in reducing EU and global CO2 emissions. The GeopolyConc project will also be integrated with leading multinational collaborative test programmes coordinated through a RILEM Technical Committee (TC DTA) which is chaired by the PI, providing a route to direct international utilisation of the project outcomes.
Max ERC Funding
1 495 458 €
Duration
Start date: 2013-09-01, End date: 2018-08-31
Project acronym GLYCOSURF
Project Surface-Based Molecular Imprinting for Glycoprotein Recognition
Researcher (PI) Paula Maria Da Silva Mendes
Host Institution (HI) THE UNIVERSITY OF BIRMINGHAM
Call Details Consolidator Grant (CoG), PE8, ERC-2013-CoG
Summary "There is now overwhelming evidence that glycosylation changes during the development and progression of various malignancies. Altered glycosylation has been implicated in cancer, immune deficiencies, neurodegenerative diseases, hereditary disorders and cardiovascular diseases. Currently, antibodies are playing a central role in enabling the detection of glycoprotein biomarkers using a variety of immunodiagnostic tests. Nonetheless, antibodies do have their own set of drawbacks that limit the commercialization of antibody sensing technology. They suffer from poor stability, need special handling and require a complicated, costly production procedure. More importantly, they lack specificity because they bind only to a small site on the biomarker and are not able to discriminate, for instance, among different glycosylated proteins. The current antibody diagnostic technology has well recognized limitations regarding their accuracy and timeliness of diagnose of disease. This project will focus on research into the means of developing a generic, robust, reliable and cost-effective alternative to monoclonal antibody technology. The project aims to exploit concepts and tools from nanochemistry, supramolecular chemistry and molecular imprinting to provide highly innovative synthetic recognition platforms with high sensitivity and specificity for glycoproteins. Such novel type of platforms will make a profound and significant impact in the broad fields of biosensors and protein separation devices with applications in many areas such as biomedical diagnostics, pharmaceutical industry, defense and environmental monitoring. The proposed technology may open an untraveled path in the successful diagnosis, prognosis and monitoring of therapeutic treatment for major diseases such as cancer, immune deficiencies, neurodegenerative diseases, hereditary disorders and cardiovascular diseases."
Summary
"There is now overwhelming evidence that glycosylation changes during the development and progression of various malignancies. Altered glycosylation has been implicated in cancer, immune deficiencies, neurodegenerative diseases, hereditary disorders and cardiovascular diseases. Currently, antibodies are playing a central role in enabling the detection of glycoprotein biomarkers using a variety of immunodiagnostic tests. Nonetheless, antibodies do have their own set of drawbacks that limit the commercialization of antibody sensing technology. They suffer from poor stability, need special handling and require a complicated, costly production procedure. More importantly, they lack specificity because they bind only to a small site on the biomarker and are not able to discriminate, for instance, among different glycosylated proteins. The current antibody diagnostic technology has well recognized limitations regarding their accuracy and timeliness of diagnose of disease. This project will focus on research into the means of developing a generic, robust, reliable and cost-effective alternative to monoclonal antibody technology. The project aims to exploit concepts and tools from nanochemistry, supramolecular chemistry and molecular imprinting to provide highly innovative synthetic recognition platforms with high sensitivity and specificity for glycoproteins. Such novel type of platforms will make a profound and significant impact in the broad fields of biosensors and protein separation devices with applications in many areas such as biomedical diagnostics, pharmaceutical industry, defense and environmental monitoring. The proposed technology may open an untraveled path in the successful diagnosis, prognosis and monitoring of therapeutic treatment for major diseases such as cancer, immune deficiencies, neurodegenerative diseases, hereditary disorders and cardiovascular diseases."
Max ERC Funding
1 894 046 €
Duration
Start date: 2014-12-01, End date: 2019-11-30
Project acronym GQCOP
Project Genuine Quantumness in Cooperative Phenomena
Researcher (PI) Gerardo Adesso
Host Institution (HI) THE UNIVERSITY OF NOTTINGHAM
Call Details Starting Grant (StG), PE2, ERC-2014-STG
Summary The proposed research programme addresses issues of fundamental and technological importance in quantum information science and its interplay with complexity. The main aim of this project is to provide a new paradigmatic foundation for the characterisation of quantumness in cooperative phenomena and to develop novel platforms for its practical utilisation in quantum technology applications.
To reach its main goal, this programme will target five specific objectives:
O1. Constructing a quantitative theory of quantumness in composite systems;
O2. Benchmarking genuine quantumness in information and communication protocols;
O3. Devising practical solutions for quantum-enhanced metrology in noisy conditions;
O4. Developing quantum thermal engineering for refrigerators and heat engines;
O5. Establishing a cybernetics framework for regulative phenomena in the quantum domain.
This project is deeply driven by the scientific curiosity to explore the ultimate range of applicability of quantum mechanics. Along the route to satisfying such curiosity, this project will fulfill a crucial two-fold mission. On the fundamental side, it will lead to a radically new level of understanding of quantumness, in its various manifestations, and the functional role it plays for natural and artificial complex systems traditionally confined to a classical domain of investigation. On the practical side, it will deliver novel concrete recipes for communication, sensing and cooling technologies in realistic conditions, rigorously assessing in which ways and to which extent these can be enhanced by engineering and harnessing quantumness.
Along with a skillful team which this grant will allow to assemble, benefitting from the vivid research environment at Nottingham, and mainly thanks to his creativity, broad mathematical and physical preparation and relevant inter-disciplinary expertise, the applicant is in a unique position to accomplish this timely and ambitious mission.
Summary
The proposed research programme addresses issues of fundamental and technological importance in quantum information science and its interplay with complexity. The main aim of this project is to provide a new paradigmatic foundation for the characterisation of quantumness in cooperative phenomena and to develop novel platforms for its practical utilisation in quantum technology applications.
To reach its main goal, this programme will target five specific objectives:
O1. Constructing a quantitative theory of quantumness in composite systems;
O2. Benchmarking genuine quantumness in information and communication protocols;
O3. Devising practical solutions for quantum-enhanced metrology in noisy conditions;
O4. Developing quantum thermal engineering for refrigerators and heat engines;
O5. Establishing a cybernetics framework for regulative phenomena in the quantum domain.
This project is deeply driven by the scientific curiosity to explore the ultimate range of applicability of quantum mechanics. Along the route to satisfying such curiosity, this project will fulfill a crucial two-fold mission. On the fundamental side, it will lead to a radically new level of understanding of quantumness, in its various manifestations, and the functional role it plays for natural and artificial complex systems traditionally confined to a classical domain of investigation. On the practical side, it will deliver novel concrete recipes for communication, sensing and cooling technologies in realistic conditions, rigorously assessing in which ways and to which extent these can be enhanced by engineering and harnessing quantumness.
Along with a skillful team which this grant will allow to assemble, benefitting from the vivid research environment at Nottingham, and mainly thanks to his creativity, broad mathematical and physical preparation and relevant inter-disciplinary expertise, the applicant is in a unique position to accomplish this timely and ambitious mission.
Max ERC Funding
1 351 461 €
Duration
Start date: 2015-05-01, End date: 2020-04-30
Project acronym GRACE
Project Genetic Record of Atmospheric Carbon dioxidE (GRACE)
Researcher (PI) Rosalind Rickaby
Host Institution (HI) THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Call Details Starting Grant (StG), PE8, ERC-2007-StG
Summary Two key variables, temperature and atmospheric carbon dioxide (pCO2), define the sensitivity of the Earth’s climate system. The geological record provides our only evidence of the past climate sensitivity of the Earth system, but there is no direct quantitative measure of pCO2 or temperature beyond the 650 kyr extent of the Antarctic ice cores. The reconstruction of past climate, on timescales of millions of years, relies on the analysis of chemical or isotopic proxies in preserved shells or organic matter. Such indirect approaches depend upon empirical calibration in modern species, without understanding the biological mechanisms that underpin the incorporation of the climate signal. The intention of this ERC grant proposal is to establish a research team to investigate the “living geological record” to address this major gap in climate research. I hypothesise that direct climate signals of the past are harboured within, and can ultimately be deciphered from, the genetic make up of extant organisms. Specifically, I propose an innovative approach to the constraint of the evolution of atmospheric pCO2 during the Cenozoic. The approach is based on the statistical signal of positive selection of adaptation within the genetic sequences of marine algal Rubisco, the notoriously inefficient enzyme responsible for photosynthetic carbon fixation, but supplemented by analysis of allied carbon concentrating mechanisms. As a calibration, I will characterise the biochemical properties of Rubisco in terms of specificity for pCO2, isotopic fractionation and kinetics, from a range of marine phytoplankton. The prime motivation is a history of pCO2, but the project will yield additional insight into the feedback between phytoplankton and climate, the carbon isotopic signatures of the geological record and the mechanistic link between genetic encoding and specific
Summary
Two key variables, temperature and atmospheric carbon dioxide (pCO2), define the sensitivity of the Earth’s climate system. The geological record provides our only evidence of the past climate sensitivity of the Earth system, but there is no direct quantitative measure of pCO2 or temperature beyond the 650 kyr extent of the Antarctic ice cores. The reconstruction of past climate, on timescales of millions of years, relies on the analysis of chemical or isotopic proxies in preserved shells or organic matter. Such indirect approaches depend upon empirical calibration in modern species, without understanding the biological mechanisms that underpin the incorporation of the climate signal. The intention of this ERC grant proposal is to establish a research team to investigate the “living geological record” to address this major gap in climate research. I hypothesise that direct climate signals of the past are harboured within, and can ultimately be deciphered from, the genetic make up of extant organisms. Specifically, I propose an innovative approach to the constraint of the evolution of atmospheric pCO2 during the Cenozoic. The approach is based on the statistical signal of positive selection of adaptation within the genetic sequences of marine algal Rubisco, the notoriously inefficient enzyme responsible for photosynthetic carbon fixation, but supplemented by analysis of allied carbon concentrating mechanisms. As a calibration, I will characterise the biochemical properties of Rubisco in terms of specificity for pCO2, isotopic fractionation and kinetics, from a range of marine phytoplankton. The prime motivation is a history of pCO2, but the project will yield additional insight into the feedback between phytoplankton and climate, the carbon isotopic signatures of the geological record and the mechanistic link between genetic encoding and specific
Max ERC Funding
1 652 907 €
Duration
Start date: 2008-09-01, End date: 2015-08-31
Project acronym GravQuantMat
Project Gravity, Black Holes and Strongly Coupled Quantum Matter
Researcher (PI) Jerome Gauntlett
Host Institution (HI) IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Call Details Advanced Grant (AdG), PE2, ERC-2013-ADG
Summary States of matter in which the interactions between the microscopic constituents are both strong and quantum mechanical lie at the frontier of our understanding of nature. Such states appear in a wide variety of settings including high temperature superconductors, gases of cold atoms and the quark- gluon plasma created in the high-energy collisions of nuclei. Understanding the properties of such strongly coupled quantum matter poses huge conceptual challenges because standard perturbative techniques break down at strong coupling. In a remarkable development, the mathematical framework of string theory has provided a fundamentally new way to study strongly coupled quantum field theories using a dual, weakly coupled gravitational description. Furthermore, this duality states that the phase structure of the quantum field at finite temperature is precisely described by black hole geometries. The principal thrust of the proposal is to develop our understanding of these gravitational techniques in order to make contact with real world systems, particularly in condensed matter physics.
The proposal focuses on four main topics in this emerging, rapidly developing and interdisciplinary field. The first is to extend our understanding of known strongly coupled quantum critical ground states using gravitational solutions and also to search for new ones. The second is to map out the phase structure of strongly coupled quantum field theories at finite temperature by constructing a wide variety of new black hole solutions. Superconducting and spatially modulated phases will be a particular focus. Thirdly, fermion spectral functions will be calculated to extend our understanding of non-Fermi liquids, which are known to arise in many materials. The fourth topic is to explore the behaviour of strongly coupled systems in situations far from thermal equilibrium by studying the dynamical process of black hole formation.
Summary
States of matter in which the interactions between the microscopic constituents are both strong and quantum mechanical lie at the frontier of our understanding of nature. Such states appear in a wide variety of settings including high temperature superconductors, gases of cold atoms and the quark- gluon plasma created in the high-energy collisions of nuclei. Understanding the properties of such strongly coupled quantum matter poses huge conceptual challenges because standard perturbative techniques break down at strong coupling. In a remarkable development, the mathematical framework of string theory has provided a fundamentally new way to study strongly coupled quantum field theories using a dual, weakly coupled gravitational description. Furthermore, this duality states that the phase structure of the quantum field at finite temperature is precisely described by black hole geometries. The principal thrust of the proposal is to develop our understanding of these gravitational techniques in order to make contact with real world systems, particularly in condensed matter physics.
The proposal focuses on four main topics in this emerging, rapidly developing and interdisciplinary field. The first is to extend our understanding of known strongly coupled quantum critical ground states using gravitational solutions and also to search for new ones. The second is to map out the phase structure of strongly coupled quantum field theories at finite temperature by constructing a wide variety of new black hole solutions. Superconducting and spatially modulated phases will be a particular focus. Thirdly, fermion spectral functions will be calculated to extend our understanding of non-Fermi liquids, which are known to arise in many materials. The fourth topic is to explore the behaviour of strongly coupled systems in situations far from thermal equilibrium by studying the dynamical process of black hole formation.
Max ERC Funding
1 963 542 €
Duration
Start date: 2014-03-01, End date: 2019-02-28
Project acronym GSF
Project Two-body dynamics in general relativity: the self-force approach
Researcher (PI) Leor Barack
Host Institution (HI) UNIVERSITY OF SOUTHAMPTON
Call Details Starting Grant (StG), PE2, ERC-2012-StG_20111012
Summary "The gravitational two-body problem is a longstanding open problem in General Relativity, dating back to work by Einstein himself in the 1930s. Unlike in Newtonian theory, bound binary orbits in relativity are never periodic: the system loses energy via emission of gravitational waves (GWs), and the two masses gradually inspiral until they merge. The description of this radiative dynamics is extremely challenging, not least due to the non-linearity of Einstein's field equations. The exciting prospects for observing GWs from inspiralling and merging compact binaries using detectors like VIRGO (in Europe) and LIGO (in the US) has renewed interest in this old problem, and provides a modern context to it.
The radiative inspiral of compact stars into massive black holes is a key source for low-frequency GW astronomy. The intricate GW signature of such inspirals will allow precision tests of Relativity in its most extreme regime. The inspiral can be modelled within Relativity using semi-analytic perturbation methods: the small object is seen as moving on the background of the large hole, and the problem reduces to computing the back-reaction force, aka ""self force"", acting on the small object as it interacts with its own gravitational field.
My team has been involved in breakthrough research into the nature of the self force in curved spacetime, establishing international leadership in the field. Our main goals in this project are (1) to compute accurate self-forced inspiral trajectories for realistic (spinning) black hole binaries together with theoretical waveforms for GW searches; (2) by means of synergy with post-Newtonian theory and numerical relativity, to inform a universal model of binary inspirals at any mass ratio; and (3) to explore several exotic aspects of the post-geodesic dynamics, including transient resonances in generic inspirals, critical behavior near the capture threshold, and the possible role of the self-force as a ""cosmic censor""."
Summary
"The gravitational two-body problem is a longstanding open problem in General Relativity, dating back to work by Einstein himself in the 1930s. Unlike in Newtonian theory, bound binary orbits in relativity are never periodic: the system loses energy via emission of gravitational waves (GWs), and the two masses gradually inspiral until they merge. The description of this radiative dynamics is extremely challenging, not least due to the non-linearity of Einstein's field equations. The exciting prospects for observing GWs from inspiralling and merging compact binaries using detectors like VIRGO (in Europe) and LIGO (in the US) has renewed interest in this old problem, and provides a modern context to it.
The radiative inspiral of compact stars into massive black holes is a key source for low-frequency GW astronomy. The intricate GW signature of such inspirals will allow precision tests of Relativity in its most extreme regime. The inspiral can be modelled within Relativity using semi-analytic perturbation methods: the small object is seen as moving on the background of the large hole, and the problem reduces to computing the back-reaction force, aka ""self force"", acting on the small object as it interacts with its own gravitational field.
My team has been involved in breakthrough research into the nature of the self force in curved spacetime, establishing international leadership in the field. Our main goals in this project are (1) to compute accurate self-forced inspiral trajectories for realistic (spinning) black hole binaries together with theoretical waveforms for GW searches; (2) by means of synergy with post-Newtonian theory and numerical relativity, to inform a universal model of binary inspirals at any mass ratio; and (3) to explore several exotic aspects of the post-geodesic dynamics, including transient resonances in generic inspirals, critical behavior near the capture threshold, and the possible role of the self-force as a ""cosmic censor""."
Max ERC Funding
1 459 268 €
Duration
Start date: 2012-10-01, End date: 2017-09-30
Project acronym HAZE
Project Reducing the Burden of Smouldering Megafires: an Earth-Scale Challenge
Researcher (PI) Guillermo Jose Rein
Host Institution (HI) IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Call Details Consolidator Grant (CoG), PE8, ERC-2015-CoG
Summary Smouldering megafires are the largest and longest-burning fires on Earth. They destroy essential peatland ecosystems, and are responsible for 15% of annual global greenhouse gas emissions. This is the same amount attributed to the whole of the European Union, and yet it is not accounted for in global carbon budgets. Peat fires also induce surges of respiratory emergencies in the population and disrupt shipping and aviation routes for long periods, weeks even months. The ambition of HAZE is to advance the science and create the technology that will reduce the burden of smouldering fires. Despite their importance, we do not understand how smouldering fires ignite, spread or extinguish, which impedes the development of any successful mitigation strategy. Megafires are routinely fought across the globe with techniques that were developed for flaming fires, and are thus ineffective for smouldering. Moreover, the burning of deep peat affects older soil carbon that has not been part of the active carbon cycle for centuries to millennia, and thus creates a positive feedback to the climate system. HAZE wants to turn the challenges faced by smouldering research into opportunities and has the following three novel aims:
1) To conduct controlled laboratory experiments and discover how peat fires ignite, spread and extinguish.
2) To develop multidimensional computational models for the field scale (~1 km) and simulate the real phenomena.
3) To create pathways for novel mitigation technologies in accurate prevention, quick detection systems, and simulation-driven suppression strategies.
With my proposal, Europe has the chance to lead the way and pioneer technologies against this Earth-scale and important but unconventional source of emissions. I am confident that with the support of ERC, I can deliver the science and excellence needed to tackle this global challenge, and in doing so, I will advance the knowledge frontier, foster innovation and develop new young talent for Europe
Summary
Smouldering megafires are the largest and longest-burning fires on Earth. They destroy essential peatland ecosystems, and are responsible for 15% of annual global greenhouse gas emissions. This is the same amount attributed to the whole of the European Union, and yet it is not accounted for in global carbon budgets. Peat fires also induce surges of respiratory emergencies in the population and disrupt shipping and aviation routes for long periods, weeks even months. The ambition of HAZE is to advance the science and create the technology that will reduce the burden of smouldering fires. Despite their importance, we do not understand how smouldering fires ignite, spread or extinguish, which impedes the development of any successful mitigation strategy. Megafires are routinely fought across the globe with techniques that were developed for flaming fires, and are thus ineffective for smouldering. Moreover, the burning of deep peat affects older soil carbon that has not been part of the active carbon cycle for centuries to millennia, and thus creates a positive feedback to the climate system. HAZE wants to turn the challenges faced by smouldering research into opportunities and has the following three novel aims:
1) To conduct controlled laboratory experiments and discover how peat fires ignite, spread and extinguish.
2) To develop multidimensional computational models for the field scale (~1 km) and simulate the real phenomena.
3) To create pathways for novel mitigation technologies in accurate prevention, quick detection systems, and simulation-driven suppression strategies.
With my proposal, Europe has the chance to lead the way and pioneer technologies against this Earth-scale and important but unconventional source of emissions. I am confident that with the support of ERC, I can deliver the science and excellence needed to tackle this global challenge, and in doing so, I will advance the knowledge frontier, foster innovation and develop new young talent for Europe
Max ERC Funding
1 958 900 €
Duration
Start date: 2016-05-01, End date: 2021-04-30
Project acronym HELIOS
Project Heavy Element Laser Ionization Spectroscopy
Researcher (PI) Pieter Van Duppen
Host Institution (HI) KATHOLIEKE UNIVERSITEIT LEUVEN
Call Details Advanced Grant (AdG), PE2, ERC-2011-ADG_20110209
Summary The aim of this proposal is to develop a novel laser-spectroscopy method and to study nuclear and atomic properties of heaviests elements in order to address the following key questions:
- Is the existence of the heaviest isotopes determined by the interplay between single-particle and collective nucleon degrees of freedom in the atomic nucleus?
- How do relativistic effects and isotopic composition influence the valence atomic structure of the heaviest elements?
The new approach is based on in-gas jet, high-repetition, high-resolution laser resonance ionization spectroscopy of short-lived nuclear-reaction products stopped in a buffer gas cell. The final goal is to couple the new system to the strongest production facility under construction at the ESFRI-listed SPIRAL-2 facility at GANIL (France) and to study isotopes from actinium to nobelium and heavier elements.
An increase of the primary intensity, efficiency, selectivity and spectral resolution by one order of magnitude compared to present-day techniques is envisaged, which is essential to obtain the required data .
The challenges are:
- decoupling the high-intensity heavy ion production beam (> 10^14 particles per second) from the low-intensity reaction products (few atoms per second)
- cooling of the reaction products from MeV/u to meV/u within less then hundred milliseconds
- separating the wanted from the, by orders of magnitude overwhelming, unwanted isotopes
- performing high-resolution laser spectroscopy on a minute amount of atoms in an efficient way.
Nuclear properties (charge radii, nuclear moments and spins) as well as atomic properties (transition energies and ionization potentials) will be deduced in regions of the nuclear chart where they are not known: the neutron-deficient isotopes of the actinide elements, up to nobelium (Z = 102) and beyond. The data will validate state-of-the-art calculations, identify critical weaknesses and guide further theoretical developments.
Summary
The aim of this proposal is to develop a novel laser-spectroscopy method and to study nuclear and atomic properties of heaviests elements in order to address the following key questions:
- Is the existence of the heaviest isotopes determined by the interplay between single-particle and collective nucleon degrees of freedom in the atomic nucleus?
- How do relativistic effects and isotopic composition influence the valence atomic structure of the heaviest elements?
The new approach is based on in-gas jet, high-repetition, high-resolution laser resonance ionization spectroscopy of short-lived nuclear-reaction products stopped in a buffer gas cell. The final goal is to couple the new system to the strongest production facility under construction at the ESFRI-listed SPIRAL-2 facility at GANIL (France) and to study isotopes from actinium to nobelium and heavier elements.
An increase of the primary intensity, efficiency, selectivity and spectral resolution by one order of magnitude compared to present-day techniques is envisaged, which is essential to obtain the required data .
The challenges are:
- decoupling the high-intensity heavy ion production beam (> 10^14 particles per second) from the low-intensity reaction products (few atoms per second)
- cooling of the reaction products from MeV/u to meV/u within less then hundred milliseconds
- separating the wanted from the, by orders of magnitude overwhelming, unwanted isotopes
- performing high-resolution laser spectroscopy on a minute amount of atoms in an efficient way.
Nuclear properties (charge radii, nuclear moments and spins) as well as atomic properties (transition energies and ionization potentials) will be deduced in regions of the nuclear chart where they are not known: the neutron-deficient isotopes of the actinide elements, up to nobelium (Z = 102) and beyond. The data will validate state-of-the-art calculations, identify critical weaknesses and guide further theoretical developments.
Max ERC Funding
2 458 397 €
Duration
Start date: 2012-03-01, End date: 2017-02-28
Project acronym HEXTREME
Project Hexahedral mesh generation in real time
Researcher (PI) Jean-François REMACLE
Host Institution (HI) UNIVERSITE CATHOLIQUE DE LOUVAIN
Call Details Advanced Grant (AdG), PE8, ERC-2015-AdG
Summary Over one million finite element analyses are preformed in engineering offices every day and finite elements come with the price of mesh generation. This proposal aims at creating two breakthroughs in the art of mesh generation that will be directly beneficial to the finite element community at large. The first challenge of HEXTREME is to take advantage of the massively multi-threaded nature of modern computers and to parallelize all the aspects of the mesh generation process at a fine grain level. Reducing the meshing time by more than one order of magnitude is an ambitious objective: if minutes can become seconds, then success in this research would definitively radically change the way in which engineers deal with mesh generation. This project then proposes an innovative approach to overcoming the major difficulty associated with mesh generation: it aims at providing a fast and reliable solution to the problem of conforming hexahedral mesh generation. Quadrilateral meshes in 2D and hexahedral meshes in 3D are usually considered to be superior to triangular/tetrahedral meshes. Even though direct tetrahedral meshing techniques have reached a level of robustness that allow us to treat general 3D domains, there may never exist a direct algorithm for building unstructured hex-meshes in general 3D domains. In HEXTREME, an indirect approach is envisaged that relies on recent developments in various domains of applied mathematics and computer science such as graph theory, combinatorial optimization or computational geometry. The methodology that is proposed for hex meshing is finally extended to the difficult problem of boundary layer meshing. Mesh generation is one important step of the engineering analysis process. Yet, a mesh is a tool and not an aim. A specific task of the project is dedicated to the interaction with research partners that are committed to beta-test the results of HEXTREME. All the results of HEXTREME will be provided as an open source in Gmsh.
Summary
Over one million finite element analyses are preformed in engineering offices every day and finite elements come with the price of mesh generation. This proposal aims at creating two breakthroughs in the art of mesh generation that will be directly beneficial to the finite element community at large. The first challenge of HEXTREME is to take advantage of the massively multi-threaded nature of modern computers and to parallelize all the aspects of the mesh generation process at a fine grain level. Reducing the meshing time by more than one order of magnitude is an ambitious objective: if minutes can become seconds, then success in this research would definitively radically change the way in which engineers deal with mesh generation. This project then proposes an innovative approach to overcoming the major difficulty associated with mesh generation: it aims at providing a fast and reliable solution to the problem of conforming hexahedral mesh generation. Quadrilateral meshes in 2D and hexahedral meshes in 3D are usually considered to be superior to triangular/tetrahedral meshes. Even though direct tetrahedral meshing techniques have reached a level of robustness that allow us to treat general 3D domains, there may never exist a direct algorithm for building unstructured hex-meshes in general 3D domains. In HEXTREME, an indirect approach is envisaged that relies on recent developments in various domains of applied mathematics and computer science such as graph theory, combinatorial optimization or computational geometry. The methodology that is proposed for hex meshing is finally extended to the difficult problem of boundary layer meshing. Mesh generation is one important step of the engineering analysis process. Yet, a mesh is a tool and not an aim. A specific task of the project is dedicated to the interaction with research partners that are committed to beta-test the results of HEXTREME. All the results of HEXTREME will be provided as an open source in Gmsh.
Max ERC Funding
2 244 238 €
Duration
Start date: 2016-10-01, End date: 2021-09-30
Project acronym HIDGR
Project Higher dimensional general relativity: explicit solutions and the classification and stability of black holes
Researcher (PI) Harvey Stephen Reall
Host Institution (HI) THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Call Details Starting Grant (StG), PE2, ERC-2011-StG_20101014
Summary "Higher-dimensional General Relativity (GR) is well-motivated by string theory e.g. via the gauge/gravity correspondence or scenarios that predict black hole production at the Large Hadron Collider. In this proposal it is regarded as a self-contained mathematical subject that extends conventional 4d GR. It is known that higher-dimensional GR exhibits qualitative differences from 4d GR, especially for black holes,
e.g. there exist ""black ring"" solutions describing rotating, donut-shaped black holes. It is likely that there are many other interesting solutions. This project will investigate the following topics in higher-dimensional GR: 1. Methods for obtaining explicit solutions of the Einstein equation, especially those based on algebraic classification of the Weyl tensor; 2. Classical stability of black holes; 3. Classification of black hole
solutions: What data is required to specify uniquely black hole solutions? What are the allowed topologies and symmetries of black holes?"
Summary
"Higher-dimensional General Relativity (GR) is well-motivated by string theory e.g. via the gauge/gravity correspondence or scenarios that predict black hole production at the Large Hadron Collider. In this proposal it is regarded as a self-contained mathematical subject that extends conventional 4d GR. It is known that higher-dimensional GR exhibits qualitative differences from 4d GR, especially for black holes,
e.g. there exist ""black ring"" solutions describing rotating, donut-shaped black holes. It is likely that there are many other interesting solutions. This project will investigate the following topics in higher-dimensional GR: 1. Methods for obtaining explicit solutions of the Einstein equation, especially those based on algebraic classification of the Weyl tensor; 2. Classical stability of black holes; 3. Classification of black hole
solutions: What data is required to specify uniquely black hole solutions? What are the allowed topologies and symmetries of black holes?"
Max ERC Funding
1 337 044 €
Duration
Start date: 2011-11-01, End date: 2016-10-31
Project acronym HIENA
Project Hierarchical Carbon Nanomaterials
Researcher (PI) Michael Franciscus Lucas De Volder
Host Institution (HI) THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Call Details Starting Grant (StG), PE8, ERC-2013-StG
Summary "Over the past years, carbon nanomaterial such as graphene and carbon nanotubes (CNTs) have attracted the interest of scientists, because some of their properties are unlike any other engineering material. Individual graphene sheets and CNTs have shown a Youngs Modulus of 1 TPa and a tensile strength of 100 GPa, hereby exceeding steel at only a fraction of its weight. Further, they offer high currents carrying capacities of 10^9 A/cm², and thermal conductivities up to 3500 W/mK, exceeding diamond. Importantly, these off-the-chart properties are only valid for high quality individualized nanotubes or sheets. However, most engineering applications require the assembly of tens to millions of these nanoparticles into one device. Unfortunately, the mechanical and electronic figures of merit of such assembled materials typically drop by at least an order of magnitude in comparison to the constituent nanoparticles.
In this ERC project, we aim at the development of new techniques to create structured assemblies of carbon nanoparticles. Herein we emphasize the importance of controlling hierarchical arrangement at different length scales in order to engineer the properties of the final device. The project will follow a methodical approach, bringing together different fields of expertise ranging from macro- and microscale manufacturing, to nanoscale material synthesis and mesoscale chemical surface modification. For instance, we will pursue combined top-down microfabrication and bottom-up self-assembly, accompanied with surface modification through hydrothermal processing.
This research will impact scientific understanding of how nanotubes and nanosheets interact, and will create new hierarchical assembly techniques for nanomaterials. Further, this ERC project pursues applications with high societal impact, including energy storage and water filtration. Finally, HIENA will tie relations with EU’s rich CNT industry to disseminate its technologic achievements."
Summary
"Over the past years, carbon nanomaterial such as graphene and carbon nanotubes (CNTs) have attracted the interest of scientists, because some of their properties are unlike any other engineering material. Individual graphene sheets and CNTs have shown a Youngs Modulus of 1 TPa and a tensile strength of 100 GPa, hereby exceeding steel at only a fraction of its weight. Further, they offer high currents carrying capacities of 10^9 A/cm², and thermal conductivities up to 3500 W/mK, exceeding diamond. Importantly, these off-the-chart properties are only valid for high quality individualized nanotubes or sheets. However, most engineering applications require the assembly of tens to millions of these nanoparticles into one device. Unfortunately, the mechanical and electronic figures of merit of such assembled materials typically drop by at least an order of magnitude in comparison to the constituent nanoparticles.
In this ERC project, we aim at the development of new techniques to create structured assemblies of carbon nanoparticles. Herein we emphasize the importance of controlling hierarchical arrangement at different length scales in order to engineer the properties of the final device. The project will follow a methodical approach, bringing together different fields of expertise ranging from macro- and microscale manufacturing, to nanoscale material synthesis and mesoscale chemical surface modification. For instance, we will pursue combined top-down microfabrication and bottom-up self-assembly, accompanied with surface modification through hydrothermal processing.
This research will impact scientific understanding of how nanotubes and nanosheets interact, and will create new hierarchical assembly techniques for nanomaterials. Further, this ERC project pursues applications with high societal impact, including energy storage and water filtration. Finally, HIENA will tie relations with EU’s rich CNT industry to disseminate its technologic achievements."
Max ERC Funding
1 496 379 €
Duration
Start date: 2014-01-01, End date: 2018-12-31
Project acronym HIGGSBNDL
Project Higgs bundles: Supersymmetric Gauge Theories and Geometry
Researcher (PI) Sakura Schafer-Nameki
Host Institution (HI) THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Call Details Consolidator Grant (CoG), PE2, ERC-2015-CoG
Summary String theory provides a unified description of particle physics and gravity, within a consistent theory of quantum gravity. The goal of this research is to develop both the phenomenological implications as well as conceptual foundations of string theory and its non-perturbative completions, M- and F-theory. Both, seemingly independent, questions are deeply connected to a mathematical structure, the Higgs bundle, which characterizes supersymmetric vacua of dimensionally reduced gauge theories, and insights into the moduli space of Higgs bundles will result in a fruitful cross-connection between these subjects.
For string theory to engage in a meaningful dialog with particle physics, it is paramount to gain a universal understanding of the low energy effective theories that can arise from it. Building on the success of studying F-theory vacua in terms of Higgs bundles, we propose to develop the Higgs bundle approach for M-theory on G2-manifolds, leading to a universal characterization of the low energy physics. Methods developed for Higgs bundles of d = 3 N = 2 theories obtained from M5-branes on three-manifolds will be used in this process. Associated to each Higgs bundle is a local G2 manifold and we propose a way (using new results in geometry) to construct compact G2 spaces associated to these, which manifestly ensure the phenomenological soundness of the compactifications.
Higgs bundles have recently also played a key role in studying the compactifications of the M5-brane in M-theory. We propose and develop a new duality between a d = 4 theory on a four-manifold X4 and a d = 2, N = (2,0) supersymmetric gauge theory on a two-sphere S2, obtained by considering the M5-brane theory on X4xS2. The supersymmetric vacua have a characterization in terms of Higgs bundles, which can be studied with tools developed for F- theory Higgs bundles on four-manifolds. Furthermore we propose a concrete approach to derive this duality from first principles.
Summary
String theory provides a unified description of particle physics and gravity, within a consistent theory of quantum gravity. The goal of this research is to develop both the phenomenological implications as well as conceptual foundations of string theory and its non-perturbative completions, M- and F-theory. Both, seemingly independent, questions are deeply connected to a mathematical structure, the Higgs bundle, which characterizes supersymmetric vacua of dimensionally reduced gauge theories, and insights into the moduli space of Higgs bundles will result in a fruitful cross-connection between these subjects.
For string theory to engage in a meaningful dialog with particle physics, it is paramount to gain a universal understanding of the low energy effective theories that can arise from it. Building on the success of studying F-theory vacua in terms of Higgs bundles, we propose to develop the Higgs bundle approach for M-theory on G2-manifolds, leading to a universal characterization of the low energy physics. Methods developed for Higgs bundles of d = 3 N = 2 theories obtained from M5-branes on three-manifolds will be used in this process. Associated to each Higgs bundle is a local G2 manifold and we propose a way (using new results in geometry) to construct compact G2 spaces associated to these, which manifestly ensure the phenomenological soundness of the compactifications.
Higgs bundles have recently also played a key role in studying the compactifications of the M5-brane in M-theory. We propose and develop a new duality between a d = 4 theory on a four-manifold X4 and a d = 2, N = (2,0) supersymmetric gauge theory on a two-sphere S2, obtained by considering the M5-brane theory on X4xS2. The supersymmetric vacua have a characterization in terms of Higgs bundles, which can be studied with tools developed for F- theory Higgs bundles on four-manifolds. Furthermore we propose a concrete approach to derive this duality from first principles.
Max ERC Funding
1 794 562 €
Duration
Start date: 2016-09-01, End date: 2021-08-31
Project acronym High-Spin-Grav
Project Higher Spin Gravity and Generalized Spacetime Geometry
Researcher (PI) Marc HENNEAUX
Host Institution (HI) UNIVERSITE LIBRE DE BRUXELLES
Call Details Advanced Grant (AdG), PE2, ERC-2015-AdG
Summary Extensions of Einstein’s gravity containing higher spin gauge fields (massless fields with spin greater than two) constitute a very active and challenging field of research, raising many fascinating issues and questions in different areas of physics. However, in spite of the impressive achievements already in store, it is fair to say that higher spin gravity has not delivered its full potential yet and still faces a rich number of challenges, both conceptual and technical. The objective of this proposal is to deepen our understanding of higher spin gravity, following five interconnected central themes that will constitute the backbone of the project: (i) how to construct an action principle; (ii) how to understand the generalized space-time geometry invariant under the higher-spin gauge symmetry – a key fundamental issue in the project; (iii) what is the precise asymptotic structure of the theory at infinity; (iv) what is the connection of the higher spin algebras with the hidden symmetries of gravitational theories; (v) what are the implications of hypersymmetry, which is the higher-spin version of supersymmetry. Holography in three and higher dimensions will constitute an essential tool.
One of the motivations of the project is the connection of higher spin gravity with tensionless string theory and consistent theories of quantum gravity.
Summary
Extensions of Einstein’s gravity containing higher spin gauge fields (massless fields with spin greater than two) constitute a very active and challenging field of research, raising many fascinating issues and questions in different areas of physics. However, in spite of the impressive achievements already in store, it is fair to say that higher spin gravity has not delivered its full potential yet and still faces a rich number of challenges, both conceptual and technical. The objective of this proposal is to deepen our understanding of higher spin gravity, following five interconnected central themes that will constitute the backbone of the project: (i) how to construct an action principle; (ii) how to understand the generalized space-time geometry invariant under the higher-spin gauge symmetry – a key fundamental issue in the project; (iii) what is the precise asymptotic structure of the theory at infinity; (iv) what is the connection of the higher spin algebras with the hidden symmetries of gravitational theories; (v) what are the implications of hypersymmetry, which is the higher-spin version of supersymmetry. Holography in three and higher dimensions will constitute an essential tool.
One of the motivations of the project is the connection of higher spin gravity with tensionless string theory and consistent theories of quantum gravity.
Max ERC Funding
1 841 868 €
Duration
Start date: 2016-10-01, End date: 2021-09-30
Project acronym hipQCD
Project Highest Precision QCD predictions for a new era in Higgs boson phenomenology
Researcher (PI) Fabrizio CAOLA
Host Institution (HI) THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Call Details Starting Grant (StG), PE2, ERC-2018-STG
Summary The discovery of the Higgs boson at the CERN Large Hadron Collider (LHC) marked the beginning of a new era for particle physics. For the first time, we may have an experimentally tested and theoretically coherent picture of fundamental interactions, valid up to very high energies. A thorough exploration of the Higgs sector, to ascertain whether or not the new particle behaves as predicted by the Standard Model is now paramount.
Such an investigation is extremely challenging, and it requires absolute control over many complex Higgs signal and background processes. The goal of hipQCD is to develop innovative techniques for highest precision theoretical predictions at colliders, and to apply them for a wide range of high impact Higgs phenomenological studies at the LHC.
hipQCD addresses the major Higgs production and decay channels. Its main objectives are
1. to provide realistic predictions at ultimate accuracy for the main Higgs production and decay channels, by developing cutting-edge fully differential predictions at the third order in QCD perturbation theory for Higgs production in gluon and vector boson fusion and for Higgs decay to b quarks;
2. to allow for precise and reliable Higgs characterization studies at very high energy scales, by developing novel techniques to tackle multi-loop amplitudes in extreme kinematics configurations;
3. to significantly improve our description of Higgs production in association with other Standard Model particles, by performing groundbreaking investigations of key 2 → 3 reactions at higher orders in perturbation theory.
hipQCD involves different areas of particle theory, ranging from multi-loop amplitude computations to the study of soft/collinear structures in QFT to comprehensive Higgs LHC phenomenology. Besides their crucial impact on Higgs physics, its results could also be applied to a broader range of phenomenological studies and will be essential to fully profit from existing and future collider data.
Summary
The discovery of the Higgs boson at the CERN Large Hadron Collider (LHC) marked the beginning of a new era for particle physics. For the first time, we may have an experimentally tested and theoretically coherent picture of fundamental interactions, valid up to very high energies. A thorough exploration of the Higgs sector, to ascertain whether or not the new particle behaves as predicted by the Standard Model is now paramount.
Such an investigation is extremely challenging, and it requires absolute control over many complex Higgs signal and background processes. The goal of hipQCD is to develop innovative techniques for highest precision theoretical predictions at colliders, and to apply them for a wide range of high impact Higgs phenomenological studies at the LHC.
hipQCD addresses the major Higgs production and decay channels. Its main objectives are
1. to provide realistic predictions at ultimate accuracy for the main Higgs production and decay channels, by developing cutting-edge fully differential predictions at the third order in QCD perturbation theory for Higgs production in gluon and vector boson fusion and for Higgs decay to b quarks;
2. to allow for precise and reliable Higgs characterization studies at very high energy scales, by developing novel techniques to tackle multi-loop amplitudes in extreme kinematics configurations;
3. to significantly improve our description of Higgs production in association with other Standard Model particles, by performing groundbreaking investigations of key 2 → 3 reactions at higher orders in perturbation theory.
hipQCD involves different areas of particle theory, ranging from multi-loop amplitude computations to the study of soft/collinear structures in QFT to comprehensive Higgs LHC phenomenology. Besides their crucial impact on Higgs physics, its results could also be applied to a broader range of phenomenological studies and will be essential to fully profit from existing and future collider data.
Max ERC Funding
1 497 016 €
Duration
Start date: 2019-06-01, End date: 2024-05-31
Project acronym HISOL
Project High Energy Optical Soliton Dynamics for Efficient Sub-Femtosecond and Vacuum-Ultraviolet Pulse Generation
Researcher (PI) John Travers
Host Institution (HI) HERIOT-WATT UNIVERSITY
Call Details Starting Grant (StG), PE2, ERC-2015-STG
Summary I will study a new regime of high-energy temporal optical soliton dynamics in gas and plasma filled large-bore hollow capillaries—something never previously attempted. Soliton dynamics are fundamental to many of the most fascinating and useful nonlinear processes occurring in conventional optical fibres. Currently the peak powers demonstrated are around 100 megawatts, in hollow-core photonic crystal fibres, with energies of tens of microjoules. I aim to achieve terawatt peak power, millijoule energy-scale, soliton dynamics, and thus combine high-field laser science with the physics of solitons.
I will transfer energy from millijoule pump solitons in the near-infrared to the vacuum ultraviolet (100 nm to 200 nm, 6 eV to 12 eV), through resonant dispersive-wave emission. The emitted radiation will be coherent, ultrafast, and tunable through control of the filling gas pressure and capillary bore radius. The predicted conversion efficiencies are up to 20%, leading to VUV energies of over 400 microjoules in pulse durations of just 400 attoseconds (a single-cycle), with corresponding terawatt peak power; making this low-cost and table-top VUV source brighter than synchrotron sources. This will have wide impact: the VUV region, poorly served by current sources, is of great importance to many ultrafast spectroscopy techniques because many materials have electronic resonances there.
Through soliton self-compression I will also compress 10 femtosecond, millijoule-scale, near-infrared, pump pulses to both single-cycle and even sub-cycle waveforms, achieving sub-femtosecond durations and terawatt peak powers. These will be the shortest isolated optical pulses ever generated in the near-infrared spectral region. I will use them to drive high-energy isolated attosecond pulse generation in the XUV through HHG.
Finally, I will combine these VUV and XUV sources, in a single experiment, to perform proof-of-concept attosecond resolved VUV–XUV pump-probe spectroscopy experiments.
Summary
I will study a new regime of high-energy temporal optical soliton dynamics in gas and plasma filled large-bore hollow capillaries—something never previously attempted. Soliton dynamics are fundamental to many of the most fascinating and useful nonlinear processes occurring in conventional optical fibres. Currently the peak powers demonstrated are around 100 megawatts, in hollow-core photonic crystal fibres, with energies of tens of microjoules. I aim to achieve terawatt peak power, millijoule energy-scale, soliton dynamics, and thus combine high-field laser science with the physics of solitons.
I will transfer energy from millijoule pump solitons in the near-infrared to the vacuum ultraviolet (100 nm to 200 nm, 6 eV to 12 eV), through resonant dispersive-wave emission. The emitted radiation will be coherent, ultrafast, and tunable through control of the filling gas pressure and capillary bore radius. The predicted conversion efficiencies are up to 20%, leading to VUV energies of over 400 microjoules in pulse durations of just 400 attoseconds (a single-cycle), with corresponding terawatt peak power; making this low-cost and table-top VUV source brighter than synchrotron sources. This will have wide impact: the VUV region, poorly served by current sources, is of great importance to many ultrafast spectroscopy techniques because many materials have electronic resonances there.
Through soliton self-compression I will also compress 10 femtosecond, millijoule-scale, near-infrared, pump pulses to both single-cycle and even sub-cycle waveforms, achieving sub-femtosecond durations and terawatt peak powers. These will be the shortest isolated optical pulses ever generated in the near-infrared spectral region. I will use them to drive high-energy isolated attosecond pulse generation in the XUV through HHG.
Finally, I will combine these VUV and XUV sources, in a single experiment, to perform proof-of-concept attosecond resolved VUV–XUV pump-probe spectroscopy experiments.
Max ERC Funding
1 723 191 €
Duration
Start date: 2016-07-01, End date: 2021-06-30
Project acronym HOLOBHC
Project Holography for realistic black holes and cosmologies
Researcher (PI) Geoffrey Gaston Joseph Jean-Vincent Compère
Host Institution (HI) UNIVERSITE LIBRE DE BRUXELLES
Call Details Starting Grant (StG), PE2, ERC-2013-StG
Summary String theory provides with a consistent framework which combines quantum mechanics and gravity. Two grand challenges of fundamental physics - building realistic models of black holes and cosmologies - can be addressed in this framework thanks to novel holographic methods.
Recent astrophysical evidence indicates that some black holes rotate extremely fast, as close as 98% to the extremality bound. No quantum gravity model for such black holes has been formulated so far. My first objective is building the first model in string theory of an extremal black hole. Taking on this challenge is made possible thanks to recent advances in a remarkable duality known as the gauge/gravity correspondence. If successful, this program will pave the way to a description of quantum gravity effects that have been conjectured to occur close to the horizon of very fast rotating black holes.
Supernovae detection has established that our universe is starting a phase of accelerated expansion. This brings a pressing need to better understand still enigmatic features of de Sitter spacetime that models our universe at late times. My second objective is to derive new universal properties of the cosmological horizon of de Sitter spacetime using tools inspired from the gauge/gravity correspondence. These results will contribute to understand its remarkable entropy, which, according to the standard model of cosmology, bounds the entropy of our observable universe.
Summary
String theory provides with a consistent framework which combines quantum mechanics and gravity. Two grand challenges of fundamental physics - building realistic models of black holes and cosmologies - can be addressed in this framework thanks to novel holographic methods.
Recent astrophysical evidence indicates that some black holes rotate extremely fast, as close as 98% to the extremality bound. No quantum gravity model for such black holes has been formulated so far. My first objective is building the first model in string theory of an extremal black hole. Taking on this challenge is made possible thanks to recent advances in a remarkable duality known as the gauge/gravity correspondence. If successful, this program will pave the way to a description of quantum gravity effects that have been conjectured to occur close to the horizon of very fast rotating black holes.
Supernovae detection has established that our universe is starting a phase of accelerated expansion. This brings a pressing need to better understand still enigmatic features of de Sitter spacetime that models our universe at late times. My second objective is to derive new universal properties of the cosmological horizon of de Sitter spacetime using tools inspired from the gauge/gravity correspondence. These results will contribute to understand its remarkable entropy, which, according to the standard model of cosmology, bounds the entropy of our observable universe.
Max ERC Funding
1 020 084 €
Duration
Start date: 2014-02-01, End date: 2019-01-31
Project acronym HPCNTW
Project High performance and ultralight carbon nanotube wires for power transmission
Researcher (PI) Krzysztof Kazimierz Koziol
Host Institution (HI) THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Call Details Starting Grant (StG), PE8, ERC-2010-StG_20091028
Summary Due to their unique molecular structure carbon nanotubes can offer high electrical conductivity and superior current density. Both of these properties are sought after, especially for overhead power transmission lines where the extremely high axial strength of nanotubes would also be a bonus. In this research proposal single wall carbon nanotubes (nanometer size tubes made of rolled up graphene sheets) with desirable dimensions and controlled way of the graphene sheet rolled up into a tube (referred to as chirality), will be synthesized and spun into fibres using two unique methods, which were developed in Cambridge. These high performance carbon nanotube fibres will be explored as flexible, lightweight, highly efficient materials for use as wires for a variety of power transmission applications.
The project will focus on achieving precise chirality control of carbon nanotubes through crystallographic manipulation of the catalyst particles using a recently-discovered in-house method. Tuning the molecular structure of individual nanotubes will achieve maximum uniformity and desired level of electrical conductivity. Next, carbon nanotube fibres will be spun using a unique process currently available only in Cambridge. The quality of fibres will be assessed, after which the fibres will be assembled into strands and cables. In the final stage, different polymeric coatings will be investigated as insulation for the wires and diverse geometries explored. There will be several fundamental benefits from the outcome of this research proposal. Demonstration of the chirality control of nanotubes, which is the “holy grail” in the field, would be important in itself, while application of the material as useful wires and cables will make it much more immediately useful
Summary
Due to their unique molecular structure carbon nanotubes can offer high electrical conductivity and superior current density. Both of these properties are sought after, especially for overhead power transmission lines where the extremely high axial strength of nanotubes would also be a bonus. In this research proposal single wall carbon nanotubes (nanometer size tubes made of rolled up graphene sheets) with desirable dimensions and controlled way of the graphene sheet rolled up into a tube (referred to as chirality), will be synthesized and spun into fibres using two unique methods, which were developed in Cambridge. These high performance carbon nanotube fibres will be explored as flexible, lightweight, highly efficient materials for use as wires for a variety of power transmission applications.
The project will focus on achieving precise chirality control of carbon nanotubes through crystallographic manipulation of the catalyst particles using a recently-discovered in-house method. Tuning the molecular structure of individual nanotubes will achieve maximum uniformity and desired level of electrical conductivity. Next, carbon nanotube fibres will be spun using a unique process currently available only in Cambridge. The quality of fibres will be assessed, after which the fibres will be assembled into strands and cables. In the final stage, different polymeric coatings will be investigated as insulation for the wires and diverse geometries explored. There will be several fundamental benefits from the outcome of this research proposal. Demonstration of the chirality control of nanotubes, which is the “holy grail” in the field, would be important in itself, while application of the material as useful wires and cables will make it much more immediately useful
Max ERC Funding
1 470 114 €
Duration
Start date: 2010-08-01, End date: 2015-07-31
Project acronym i-CaD
Project Innovative Catalyst Design for Large-Scale, Sustainable Processes
Researcher (PI) Joris Wilfried Maria Cornelius Thybaut
Host Institution (HI) UNIVERSITEIT GENT
Call Details Consolidator Grant (CoG), PE8, ERC-2013-CoG
Summary A systematic and novel, multi-scale model based catalyst design methodology will be developed. The fundamental nature of the models used is unprecedented and will represent a breakthrough compared to the more commonly applied statistical, correlative relationships. The methodology will focus on the intrinsic kinetics of (potentially) large-scale processes for the conversion of renewable feeds into fuels and chemicals. Non-ideal behaviour, caused by mass and heat transfer limitations or particular reactor hydrodynamics, will be explicitly accounted for when simulating or optimizing industrial-scale applications. The selected model reactions are situated in the area of biomass upgrading to fuels and chemicals: fast pyrolysis oil stabilization, glycerol hydrogenolysis and selective oxidation of (bio)ethanol to acetaldehyde.
For the first time, a systematic microkinetic modelling methodology will be developed for oxygenates conversion. In particular, stereochemistry in catalysis will be assessed. Two types of descriptors will be quantified: kinetic descriptors that are catalyst independent and catalyst descriptors that specifically account for the effect of the catalyst properties on the reaction kinetics. The latter will be optimized in terms of reactant conversion, product yield or selectivity. Fundamental relationships will be established between the catalyst descriptors as determined by microkinetic modelling and independently measured catalyst properties or synthesis parameters. These innovative relationships allow providing the desired, rational feedback in from optimal descriptor values towards synthesis parameters for a new catalyst generation. Their fundamental character will guarantee adequate extrapolative properties that can be exploited for the identification of a groundbreaking next catalyst generation.
Summary
A systematic and novel, multi-scale model based catalyst design methodology will be developed. The fundamental nature of the models used is unprecedented and will represent a breakthrough compared to the more commonly applied statistical, correlative relationships. The methodology will focus on the intrinsic kinetics of (potentially) large-scale processes for the conversion of renewable feeds into fuels and chemicals. Non-ideal behaviour, caused by mass and heat transfer limitations or particular reactor hydrodynamics, will be explicitly accounted for when simulating or optimizing industrial-scale applications. The selected model reactions are situated in the area of biomass upgrading to fuels and chemicals: fast pyrolysis oil stabilization, glycerol hydrogenolysis and selective oxidation of (bio)ethanol to acetaldehyde.
For the first time, a systematic microkinetic modelling methodology will be developed for oxygenates conversion. In particular, stereochemistry in catalysis will be assessed. Two types of descriptors will be quantified: kinetic descriptors that are catalyst independent and catalyst descriptors that specifically account for the effect of the catalyst properties on the reaction kinetics. The latter will be optimized in terms of reactant conversion, product yield or selectivity. Fundamental relationships will be established between the catalyst descriptors as determined by microkinetic modelling and independently measured catalyst properties or synthesis parameters. These innovative relationships allow providing the desired, rational feedback in from optimal descriptor values towards synthesis parameters for a new catalyst generation. Their fundamental character will guarantee adequate extrapolative properties that can be exploited for the identification of a groundbreaking next catalyst generation.
Max ERC Funding
1 999 877 €
Duration
Start date: 2014-06-01, End date: 2019-05-31
Project acronym IMPUNEP
Project Innovative Materials Processing Using Non-Equilibrium Plasmas
Researcher (PI) Allan Matthews
Host Institution (HI) THE UNIVERSITY OF MANCHESTER
Call Details Advanced Grant (AdG), PE8, ERC-2012-ADG_20120216
Summary Current bulk materials processing methods are nearing their limit in terms of ability to produce innovative materials with compositional and structural consistency.
The aim of this ambitious project is to remove barriers to materials development, by researching novel methods for the processing of engineering materials, using advanced non-equilibrium plasma systems, to achieve a paradigm shift in the field of materials synthesis. These new processes have the potential to overcome the constraints of existing methods and also be environmentally friendly and produce novel materials with enhanced properties (mechanical, chemical and physical).
The research will utilise plasmas in ways not used before (in bulk materials synthesis rather than thin film formation) and it will investigate different types of plasmas (vacuum, atmospheric and electrolytic), to ensure optimisation of the processing routes across the whole range of material types (including metals, ceramics and composites).
The materials synthesised will have benefits for products across key applications sectors, including energy, healthcare and aerospace. The processes will avoid harmful chemicals and will make optimum use of scarce material resources.
This interdisciplinary project (involving engineers, physicists, chemists and modellers) has fundamental “blue skies” and transformative aspects. It is also high-risk due to the aim to produce “bulk” materials at adequate rates and with consistent uniform structures, compositions and phases (and therefore properties) throughout the material. There are many challenges to overcome, relating to the study of the plasma systems and materials produced; these aspects will be pursued using empirical and modelling approaches. The research will pursue new lines of enquiry using an unconventional synthesis approach whilst operating at the interface with more established discipline areas of plasma physics, materials chemistry, process diagnostics, modelling and control.
Summary
Current bulk materials processing methods are nearing their limit in terms of ability to produce innovative materials with compositional and structural consistency.
The aim of this ambitious project is to remove barriers to materials development, by researching novel methods for the processing of engineering materials, using advanced non-equilibrium plasma systems, to achieve a paradigm shift in the field of materials synthesis. These new processes have the potential to overcome the constraints of existing methods and also be environmentally friendly and produce novel materials with enhanced properties (mechanical, chemical and physical).
The research will utilise plasmas in ways not used before (in bulk materials synthesis rather than thin film formation) and it will investigate different types of plasmas (vacuum, atmospheric and electrolytic), to ensure optimisation of the processing routes across the whole range of material types (including metals, ceramics and composites).
The materials synthesised will have benefits for products across key applications sectors, including energy, healthcare and aerospace. The processes will avoid harmful chemicals and will make optimum use of scarce material resources.
This interdisciplinary project (involving engineers, physicists, chemists and modellers) has fundamental “blue skies” and transformative aspects. It is also high-risk due to the aim to produce “bulk” materials at adequate rates and with consistent uniform structures, compositions and phases (and therefore properties) throughout the material. There are many challenges to overcome, relating to the study of the plasma systems and materials produced; these aspects will be pursued using empirical and modelling approaches. The research will pursue new lines of enquiry using an unconventional synthesis approach whilst operating at the interface with more established discipline areas of plasma physics, materials chemistry, process diagnostics, modelling and control.
Max ERC Funding
2 499 283 €
Duration
Start date: 2013-02-01, End date: 2018-09-30
Project acronym iNanoEOR
Project In-situ produced nanoparticles for enhanced oil recovery
Researcher (PI) Dongsheng Wen
Host Institution (HI) UNIVERSITY OF LEEDS
Call Details Consolidator Grant (CoG), PE8, ERC-2014-CoG
Summary The era of finding “easy oil” is coming to an end, and future supply will become more reliant on fossil fuels produced from enhanced oil recovery (EOR) process. Many EoR methods have been used, including mechanical, chemical, thermal and biological approaches, but there are still 50~70% of the original oil trapped in reservoir rocks after the primary and secondary recovery. NanoEOR, i.e, injecting nanoparticles (NPs) together with flooding fluids, is an emerging field. However all proposed applications are based on pre-fabricated NPs, which encountered enormous problems in NP stabilization and transport under reservoir conditions. This project proposes a revolutionary concept, iNanoEOR: in-situ production of NPs inside the reservoir for enhanced oil recovery. Rather than pre-manufacturing, dispersing and stabilizing NPs in advance, NPs will be produced in the reservoir by controlled hydrothermal reactions, acting as sensors to improve reservoir characterisation, or as property modifiers to effectively mobilize the trapped oil. This project will validate the innovative iNanoEOR concept by answering three questions: i) how the concept works? ii) what kind of NPs should be produced that can effectively mobilize trapped oil? iii) what are desired NP properties to allow them flow through a reservoir? Three work programs are designed, and a number of breakthroughs beyond state-of-art research are expected, which include i) proof-of-concept of the innovative iNanoEOR, ii) developing a new methodology for temperature measurement inside a reservoir, iii) revelation of the influence of NPs on EOR under reservoir-like conditions, iv) understanding the controlling factors in NP transport at different scales. The project will not only contribute directly to iNanoEOR, but also transfers the PI’s expertise in nanomaterials and multiphase flow into oil and gas sector and underpin many NP-related subsurface applications, which currently is non-existing in the Europe.
Summary
The era of finding “easy oil” is coming to an end, and future supply will become more reliant on fossil fuels produced from enhanced oil recovery (EOR) process. Many EoR methods have been used, including mechanical, chemical, thermal and biological approaches, but there are still 50~70% of the original oil trapped in reservoir rocks after the primary and secondary recovery. NanoEOR, i.e, injecting nanoparticles (NPs) together with flooding fluids, is an emerging field. However all proposed applications are based on pre-fabricated NPs, which encountered enormous problems in NP stabilization and transport under reservoir conditions. This project proposes a revolutionary concept, iNanoEOR: in-situ production of NPs inside the reservoir for enhanced oil recovery. Rather than pre-manufacturing, dispersing and stabilizing NPs in advance, NPs will be produced in the reservoir by controlled hydrothermal reactions, acting as sensors to improve reservoir characterisation, or as property modifiers to effectively mobilize the trapped oil. This project will validate the innovative iNanoEOR concept by answering three questions: i) how the concept works? ii) what kind of NPs should be produced that can effectively mobilize trapped oil? iii) what are desired NP properties to allow them flow through a reservoir? Three work programs are designed, and a number of breakthroughs beyond state-of-art research are expected, which include i) proof-of-concept of the innovative iNanoEOR, ii) developing a new methodology for temperature measurement inside a reservoir, iii) revelation of the influence of NPs on EOR under reservoir-like conditions, iv) understanding the controlling factors in NP transport at different scales. The project will not only contribute directly to iNanoEOR, but also transfers the PI’s expertise in nanomaterials and multiphase flow into oil and gas sector and underpin many NP-related subsurface applications, which currently is non-existing in the Europe.
Max ERC Funding
1 958 733 €
Duration
Start date: 2015-08-01, End date: 2020-07-31
Project acronym INSITE
Project Development and use of an integrated in silico-in vitro mesofluidics system for tissue engineering
Researcher (PI) Liesbet Laura J GERIS
Host Institution (HI) UNIVERSITE DE LIEGE
Call Details Consolidator Grant (CoG), PE8, ERC-2017-COG
Summary Tissue Engineering (TE) refers to the branch of medicine that aims to replace or regenerate functional tissue or organs using man-made living implants. As the field is moving towards more complex TE constructs with sophisticated functionalities, there is a lack of dedicated in vitro devices that allow testing the response of the complex construct as a whole, prior to implantation. Additionally, the knowledge accumulated from mechanistic and empirical in vitro and in vivo studies is often underused in the development of novel constructs due to a lack of integration of all the data in a single, in silico, platform.
The INSITE project aims to address both challenges by developing a new mesofluidics set-up for in vitro testing of TE constructs and by developing dedicated multiscale and multiphysics models that aggregate the available data and use these to design complex constructs and proper mesofluidics settings for in vitro testing. The combination of these in silico and in vitro approaches will lead to an integrated knowledge-rich mesofluidics system that provides an in vivo-like time-varying in vitro environment. The system will emulate the in vivo environment present at the (early) stages of bone regeneration including the vascularization process and the innate immune response. A proof of concept will be delivered for complex TE constructs for large bone defects and infected fractures.
To realize this project, the applicant can draw on her well-published track record and extensive network in the fields of in silico medicine and skeletal TE. If successful, INSITE will generate a shift from in vivo to in vitro work and hence a transformation of the classical R&D pipeline. Using this system will allow for a maximum of relevant in vitro research prior to the in vivo phase, which is highly needed in academia and industry with the increasing ethical (3R), financial and regulatory constraints.
Summary
Tissue Engineering (TE) refers to the branch of medicine that aims to replace or regenerate functional tissue or organs using man-made living implants. As the field is moving towards more complex TE constructs with sophisticated functionalities, there is a lack of dedicated in vitro devices that allow testing the response of the complex construct as a whole, prior to implantation. Additionally, the knowledge accumulated from mechanistic and empirical in vitro and in vivo studies is often underused in the development of novel constructs due to a lack of integration of all the data in a single, in silico, platform.
The INSITE project aims to address both challenges by developing a new mesofluidics set-up for in vitro testing of TE constructs and by developing dedicated multiscale and multiphysics models that aggregate the available data and use these to design complex constructs and proper mesofluidics settings for in vitro testing. The combination of these in silico and in vitro approaches will lead to an integrated knowledge-rich mesofluidics system that provides an in vivo-like time-varying in vitro environment. The system will emulate the in vivo environment present at the (early) stages of bone regeneration including the vascularization process and the innate immune response. A proof of concept will be delivered for complex TE constructs for large bone defects and infected fractures.
To realize this project, the applicant can draw on her well-published track record and extensive network in the fields of in silico medicine and skeletal TE. If successful, INSITE will generate a shift from in vivo to in vitro work and hence a transformation of the classical R&D pipeline. Using this system will allow for a maximum of relevant in vitro research prior to the in vivo phase, which is highly needed in academia and industry with the increasing ethical (3R), financial and regulatory constraints.
Max ERC Funding
2 161 750 €
Duration
Start date: 2018-09-01, End date: 2023-08-31
Project acronym INTEG-CV-SIM
Project An Integrated Computer Modelling Framework for Subject-Specific Cardiovascular Simulation: Applications to Disease Research, Treatment Planning, and Medical Device Design
Researcher (PI) Carlos Alberto Figueroa Alvarez
Host Institution (HI) KING'S COLLEGE LONDON
Call Details Starting Grant (StG), PE8, ERC-2012-StG_20111012
Summary Advances in numerical methods and three-dimensional imaging techniques have enabled the quantification of cardiovascular mechanics in subject-specific anatomic and physiologic models. Research efforts have been focused mainly on three areas: pathogenesis of vascular disease, development of medical devices, and virtual surgical planning. However, despite great initial promise, the actual use of patient-specific computer modelling in the clinic has been very limited. Clinical diagnosis still relies entirely on traditional methods based on imaging and invasive measurements and sampling. The same invasive trial-and-error paradigm is often seen in vascular disease research, where animal models are used profusely to quantify simple metrics that could perhaps be evaluated via non-invasive computer modelling techniques. Lastly, medical device manufacturers rely mostly on in-vitro models to investigate the anatomic variations, arterial deformations, and biomechanical forces needed for the design of stents and stent-grafts. In this project, I aim to develop an integrated image-based computer modelling framework for subject-specific cardiovascular simulation with dynamically adapting boundary conditions capable of representing alterations in the physiologic state of the patient. This computer framework will be directly applied in clinical settings to complement and enhance current diagnostic practices, working towards the goal of personalized cardiovascular medicine.
Summary
Advances in numerical methods and three-dimensional imaging techniques have enabled the quantification of cardiovascular mechanics in subject-specific anatomic and physiologic models. Research efforts have been focused mainly on three areas: pathogenesis of vascular disease, development of medical devices, and virtual surgical planning. However, despite great initial promise, the actual use of patient-specific computer modelling in the clinic has been very limited. Clinical diagnosis still relies entirely on traditional methods based on imaging and invasive measurements and sampling. The same invasive trial-and-error paradigm is often seen in vascular disease research, where animal models are used profusely to quantify simple metrics that could perhaps be evaluated via non-invasive computer modelling techniques. Lastly, medical device manufacturers rely mostly on in-vitro models to investigate the anatomic variations, arterial deformations, and biomechanical forces needed for the design of stents and stent-grafts. In this project, I aim to develop an integrated image-based computer modelling framework for subject-specific cardiovascular simulation with dynamically adapting boundary conditions capable of representing alterations in the physiologic state of the patient. This computer framework will be directly applied in clinical settings to complement and enhance current diagnostic practices, working towards the goal of personalized cardiovascular medicine.
Max ERC Funding
1 491 593 €
Duration
Start date: 2012-12-01, End date: 2018-11-30
Project acronym IntelGlazing
Project Intelligent functional glazing with self-cleaning properties to improve the energy efficiency of the built environment
Researcher (PI) Ioannis Papakonstantinou
Host Institution (HI) UNIVERSITY COLLEGE LONDON
Call Details Starting Grant (StG), PE8, ERC-2015-STG
Summary The latest forecast by the International Energy Agency predicts that the CO2 emissions from the built environment will reach 15.2Gt in 2050, double their 2007 levels. Buildings consume 40% of the primary energy in developed countries with heating and cooling alone accounting for 63% of the energy spent indoors. These trends are on an ascending trajectory - e.g. the average energy demand for air-conditioning has been growing by ~17% per year in the EU. Counterbalancing actions are urgently required to reverse them.
The objective of this proposal is to develop intelligent window insulation technologies from sustainable materials. The developed technologies will adjust the amount of radiation escaping or entering a window depending upon the ambient environmental conditions and will be capable of delivering unprecedented reductions to the energy needed for regulating the temperature in commercial and residential buildings.
Recognising the distinct requirements between newly built and existing infrastructure, two parallel concepts will be developed: i) A new class of intelligent glazing for new window installations, and, ii) a flexible, intelligent, polymer film to retrofit existing window installations. Both solutions will be enhanced with unique self-cleaning properties, bringing about additional economic benefits through a substantial reduction in maintenance costs.
Overall, we aim to develop intelligent glazing technologies that combine: i) power savings of >250 W/m2 of glazing capable of delivering >25% of energy savings and efficiency improvements >50% compared with existing static solutions; ii) visible transparency of >60% to comply with the EU standards for windows ,and, iii) self-cleaning properties that introduce a cost balance.
A number of technological breakthroughs are required to satisfy such ambitious targets which are delivered in this project by the seamless integration of nanotechnology engineering, novel photonics and advanced material synthesis.
Summary
The latest forecast by the International Energy Agency predicts that the CO2 emissions from the built environment will reach 15.2Gt in 2050, double their 2007 levels. Buildings consume 40% of the primary energy in developed countries with heating and cooling alone accounting for 63% of the energy spent indoors. These trends are on an ascending trajectory - e.g. the average energy demand for air-conditioning has been growing by ~17% per year in the EU. Counterbalancing actions are urgently required to reverse them.
The objective of this proposal is to develop intelligent window insulation technologies from sustainable materials. The developed technologies will adjust the amount of radiation escaping or entering a window depending upon the ambient environmental conditions and will be capable of delivering unprecedented reductions to the energy needed for regulating the temperature in commercial and residential buildings.
Recognising the distinct requirements between newly built and existing infrastructure, two parallel concepts will be developed: i) A new class of intelligent glazing for new window installations, and, ii) a flexible, intelligent, polymer film to retrofit existing window installations. Both solutions will be enhanced with unique self-cleaning properties, bringing about additional economic benefits through a substantial reduction in maintenance costs.
Overall, we aim to develop intelligent glazing technologies that combine: i) power savings of >250 W/m2 of glazing capable of delivering >25% of energy savings and efficiency improvements >50% compared with existing static solutions; ii) visible transparency of >60% to comply with the EU standards for windows ,and, iii) self-cleaning properties that introduce a cost balance.
A number of technological breakthroughs are required to satisfy such ambitious targets which are delivered in this project by the seamless integration of nanotechnology engineering, novel photonics and advanced material synthesis.
Max ERC Funding
1 762 823 €
Duration
Start date: 2016-03-01, End date: 2021-02-28
Project acronym INTELLICORR
Project Intelligent corrosion management underpinned by advanced engineering science
Researcher (PI) Anne NEVILLE
Host Institution (HI) UNIVERSITY OF LEEDS
Call Details Advanced Grant (AdG), PE8, ERC-2016-ADG
Summary Our planet’s population will continue to grow rapidly; between 2010 and 2025 the population will grow by 1.1bn. Urbanisation and growth of the consumer class in developing countries will lead to unprecedented demands on energy. There is arguably no bigger challenge to society than ensuring the security of affordable and environmentally-sustainable energy.
Hydrocarbons will provide a large proportion of the world’s energy for the foreseeable future. There is no escape from the critically low oil price worldwide. Innovation becomes important in this price environment. “Easy” oil has already been found; future supply will come from complex reservoirs requiring enhanced oil recovery (EOR). There is a massive growth in renewables technology; the EU is making steady progress towards its 2020 target. The EU renewables energy share increased from 8% to 15% in the decade to 2013. Energy supply and consumption brings with it the global issue of climate change as emissions from industry and transport increase. Inextricably linked to energy is the reduction of the global carbon footprint and Carbon Capture and Storage (CCS) offers the only real technology that can handle the already produced carbon dioxide.
Corrosion in energy and environmental control linking to energy supply provide the underpinning rationale for this proposal. Corrosion is one of the major life-limiting factors for energy supply (oil and gas, renewables, EOR) and in environmental pollution control (CCS) and is estimated to cost 3% GDP. This proposal brings some of the most exciting experimental and modelling engineering science to create a framework for the intelligent management of corrosion. INTELLICORR will use synchrotron techniques, advanced microscopy, numerical methods and environmental/cost analysis to bring about unprecedented advances in (a) prediction and management of localised pitting corrosion and (b) novel methods for green corrosion protection using the natural corrosion product layer
Summary
Our planet’s population will continue to grow rapidly; between 2010 and 2025 the population will grow by 1.1bn. Urbanisation and growth of the consumer class in developing countries will lead to unprecedented demands on energy. There is arguably no bigger challenge to society than ensuring the security of affordable and environmentally-sustainable energy.
Hydrocarbons will provide a large proportion of the world’s energy for the foreseeable future. There is no escape from the critically low oil price worldwide. Innovation becomes important in this price environment. “Easy” oil has already been found; future supply will come from complex reservoirs requiring enhanced oil recovery (EOR). There is a massive growth in renewables technology; the EU is making steady progress towards its 2020 target. The EU renewables energy share increased from 8% to 15% in the decade to 2013. Energy supply and consumption brings with it the global issue of climate change as emissions from industry and transport increase. Inextricably linked to energy is the reduction of the global carbon footprint and Carbon Capture and Storage (CCS) offers the only real technology that can handle the already produced carbon dioxide.
Corrosion in energy and environmental control linking to energy supply provide the underpinning rationale for this proposal. Corrosion is one of the major life-limiting factors for energy supply (oil and gas, renewables, EOR) and in environmental pollution control (CCS) and is estimated to cost 3% GDP. This proposal brings some of the most exciting experimental and modelling engineering science to create a framework for the intelligent management of corrosion. INTELLICORR will use synchrotron techniques, advanced microscopy, numerical methods and environmental/cost analysis to bring about unprecedented advances in (a) prediction and management of localised pitting corrosion and (b) novel methods for green corrosion protection using the natural corrosion product layer
Max ERC Funding
2 271 830 €
Duration
Start date: 2017-07-01, End date: 2022-06-30
Project acronym INTERDIFFUSION
Project Unraveling Interdiffusion Effects at Material Interfaces -- Learning from Tensors of Microstructure Evolution Simulations
Researcher (PI) Nele Marie Moelans
Host Institution (HI) KATHOLIEKE UNIVERSITEIT LEUVEN
Call Details Starting Grant (StG), PE8, ERC-2016-STG
Summary Multi-materials, combining various materials with different functionalities, are increasingly desired in engineering applications. Reliable material assembly is a great challenge in the development of innovative technologies. The interdiffusion microstructures formed at material interfaces are critical for the performance of the product. However, as more and more elements are involved, their complexity increases and their variety becomes immense. Furthermore, interdiffusion microstructures evolve during processing and in use of the device. Experimental testing of the long-term evolution in assembled devices is extremely time-consuming. The current level of materials models and simulation techniques does not allow in silico (or computer aided) design of multi-component material assemblies, since the parameter space is much too large.
With this project, I aim a break-through in computational materials science, using tensor decomposition techniques emerging in data-analysis to guide efficiently high-throughput interdiffusion microstructure simulation studies. The measurable outcomes aimed at, are
1) a high-performance computing software that allows to compute the effect of a huge number of material and process parameters, sufficiently large for reliable in-silico design of multi-materials, on the interdiffusion microstructure evolution, based on a tractable number of simulations, and
2) decomposed tensor descriptions for important multi-material systems enabling reliable computation of interdiffusion microstructure characteristics using a single computer.
If successful, the outcomes of this project will allow to significantly accelerate the design of innovative multi-materials. My expertise in microstructure simulations and multi-component materials, and access to collaborations with the top experts in tensor decomposition techniques and materials characterization are crucial to reach this ambitious aim.
Summary
Multi-materials, combining various materials with different functionalities, are increasingly desired in engineering applications. Reliable material assembly is a great challenge in the development of innovative technologies. The interdiffusion microstructures formed at material interfaces are critical for the performance of the product. However, as more and more elements are involved, their complexity increases and their variety becomes immense. Furthermore, interdiffusion microstructures evolve during processing and in use of the device. Experimental testing of the long-term evolution in assembled devices is extremely time-consuming. The current level of materials models and simulation techniques does not allow in silico (or computer aided) design of multi-component material assemblies, since the parameter space is much too large.
With this project, I aim a break-through in computational materials science, using tensor decomposition techniques emerging in data-analysis to guide efficiently high-throughput interdiffusion microstructure simulation studies. The measurable outcomes aimed at, are
1) a high-performance computing software that allows to compute the effect of a huge number of material and process parameters, sufficiently large for reliable in-silico design of multi-materials, on the interdiffusion microstructure evolution, based on a tractable number of simulations, and
2) decomposed tensor descriptions for important multi-material systems enabling reliable computation of interdiffusion microstructure characteristics using a single computer.
If successful, the outcomes of this project will allow to significantly accelerate the design of innovative multi-materials. My expertise in microstructure simulations and multi-component materials, and access to collaborations with the top experts in tensor decomposition techniques and materials characterization are crucial to reach this ambitious aim.
Max ERC Funding
1 496 875 €
Duration
Start date: 2017-03-01, End date: 2022-02-28
Project acronym IQFT
Project Integrable Structures in Quantum Field Theory
Researcher (PI) James Matthew Drummond
Host Institution (HI) UNIVERSITY OF SOUTHAMPTON
Call Details Consolidator Grant (CoG), PE2, ERC-2014-CoG
Summary Quantum field theory forms the foundation of our understanding of elementary particle physics. It provides the theoretical background for the interpretation of data from collider experiments. While quantum field theory is an old subject, over the last decade new features have begun to emerge which reveal new ways to understand it. In particular an astonishing simplicity has been found at the heart of the maximally supersymmetric gauge theory in four spacetime dimensions, a close cousin of Quantum Chromodynamics (QCD), which describes the strong interactions.
My research team will use the new methods I have been developing to construct explicit results for scattering amplitudes and correlation functions. We will develop these results into general statements about the analytic behaviour of scattering amplitudes. The approach will be based on my recent work on new dualities between amplitudes and Wilson loops and on new symmetries revealing an underlying integrable structure. This research will allow us to answer key foundational questions such as the origin of Regge behaviour of scattering amplitudes in the high energy limit, and the connection to string theory in the limit of strong coupling. We will also pursue the connection to quantum groups and formulate the problem of scattering amplitudes in this language. This provide a solid mathematical underpinning to the formulation of the scattering problem in quantum field theories and allow application of techniques from the field of integrable systems to gauge theories.
An enormous effort goes into performing the calculations of scattering amplitudes needed to make precise predictions for collider experiments. New techniques to handle such calculations are much needed. We will develop new tools, such as the application of differential equation methods for loop integrals and analytic bootstrap methods for amplitudes. This research will allow us to greatly improve on existing efforts to calculate processes in QCD.
Summary
Quantum field theory forms the foundation of our understanding of elementary particle physics. It provides the theoretical background for the interpretation of data from collider experiments. While quantum field theory is an old subject, over the last decade new features have begun to emerge which reveal new ways to understand it. In particular an astonishing simplicity has been found at the heart of the maximally supersymmetric gauge theory in four spacetime dimensions, a close cousin of Quantum Chromodynamics (QCD), which describes the strong interactions.
My research team will use the new methods I have been developing to construct explicit results for scattering amplitudes and correlation functions. We will develop these results into general statements about the analytic behaviour of scattering amplitudes. The approach will be based on my recent work on new dualities between amplitudes and Wilson loops and on new symmetries revealing an underlying integrable structure. This research will allow us to answer key foundational questions such as the origin of Regge behaviour of scattering amplitudes in the high energy limit, and the connection to string theory in the limit of strong coupling. We will also pursue the connection to quantum groups and formulate the problem of scattering amplitudes in this language. This provide a solid mathematical underpinning to the formulation of the scattering problem in quantum field theories and allow application of techniques from the field of integrable systems to gauge theories.
An enormous effort goes into performing the calculations of scattering amplitudes needed to make precise predictions for collider experiments. New techniques to handle such calculations are much needed. We will develop new tools, such as the application of differential equation methods for loop integrals and analytic bootstrap methods for amplitudes. This research will allow us to greatly improve on existing efforts to calculate processes in QCD.
Max ERC Funding
1 992 452 €
Duration
Start date: 2015-10-01, End date: 2020-09-30
Project acronym IQP
Project Integrated quantum photonics
Researcher (PI) Jeremy Lloyd O'brien
Host Institution (HI) UNIVERSITY OF BRISTOL
Call Details Starting Grant (StG), PE2, ERC-2009-StG
Summary Quantum information science (QIS) promises fundamental insight into the workings of nature, as we gain mastery over single and coupled quantum systems, as well as a paradigm shift in information technologies. It is a pioneering field at the interface of the physical and information sciences of major international interest, with substantial investment in North America, Asia and Europe. The first quantum technology has just arrived: quantum cryptography systems are now being used commercially to provide improved communication security. However, this is just the start of the anticipated quantum revolution that promises communication networks with the ultimate security, high precision measurements and lithography, and processors with unprecedented power. The ability to simulate quantum systems is an important task which could aide the design of new materials and pharmaceuticals, and provide profound insights into the working of complex quantum systems. Low noise, high-speed transmission, and ease of manipulation make single photons model systems for exploring fundamental scientific questions, as well as a leading approach to future quantum technologies. However, current techniques are limited by a lack of high-efficiency components, integration, and single light-matter quantum systems that would allow single photon sources and deterministic non-linearities to be developed. This ERC StG project will establish a major new research direction in Europe for photonic QIS via: 1. Development of waveguide photonic quantum circuits, sources and detectors for on-chip QIS 2. Undertake the next generation of fundamental quantum physics investigations with on-chip QIS 3. Develop `atom'-cavity photonic modules that can be used to generate single photons, entangle multiple photons in arbitrary ways, and detect single photons 4. Integrate waveguide photonics and photonic modules for fundamental QIS and quantum technologies
Summary
Quantum information science (QIS) promises fundamental insight into the workings of nature, as we gain mastery over single and coupled quantum systems, as well as a paradigm shift in information technologies. It is a pioneering field at the interface of the physical and information sciences of major international interest, with substantial investment in North America, Asia and Europe. The first quantum technology has just arrived: quantum cryptography systems are now being used commercially to provide improved communication security. However, this is just the start of the anticipated quantum revolution that promises communication networks with the ultimate security, high precision measurements and lithography, and processors with unprecedented power. The ability to simulate quantum systems is an important task which could aide the design of new materials and pharmaceuticals, and provide profound insights into the working of complex quantum systems. Low noise, high-speed transmission, and ease of manipulation make single photons model systems for exploring fundamental scientific questions, as well as a leading approach to future quantum technologies. However, current techniques are limited by a lack of high-efficiency components, integration, and single light-matter quantum systems that would allow single photon sources and deterministic non-linearities to be developed. This ERC StG project will establish a major new research direction in Europe for photonic QIS via: 1. Development of waveguide photonic quantum circuits, sources and detectors for on-chip QIS 2. Undertake the next generation of fundamental quantum physics investigations with on-chip QIS 3. Develop `atom'-cavity photonic modules that can be used to generate single photons, entangle multiple photons in arbitrary ways, and detect single photons 4. Integrate waveguide photonics and photonic modules for fundamental QIS and quantum technologies
Max ERC Funding
1 532 400 €
Duration
Start date: 2009-10-01, End date: 2014-09-30
Project acronym JetDynamics
Project High precision multi-jet dynamics at the LHC
Researcher (PI) Simon David BADGER
Host Institution (HI) UNIVERSITY OF DURHAM
Call Details Consolidator Grant (CoG), PE2, ERC-2017-COG
Summary Precision tests at high energy colliders are an essential tool for gaining insight
into the nature of the Standard Model of particle physics and the fundamental interactions. The data currently being obtained by the LHC experiments will allow a large number of observables to be measured at a percent level accuracy. This data has the potential to probe deeper into the flaws of the Standard Model. However, the complexity of theoretical predictions using perturbative quantum field theory currently prevents many of these precision tests.
JetDynamics aims for a breakthrough in precision predictions for the measurements of Standard Model interactions through the study of the dynamics of multiple strongly interacting hadronic jets. Percent level predictions for 2 to 3 scattering processes involving the Higgs boson and electroweak vector bosons will allow a unique insight into fundamental properties of the Standard Model in the new high energy region probed by the LHC.
In order to achieve this goal a complete set of quantum corrections at next-to-next-to-leading order (NNLO) in perturbation theory are required. JetDynamics bridges the gap between mathematics physics and experimental collider physics and will develop a new generation of computational tools and methods} that will overcome current bottlenecks. The work program attacks this problem on two fronts:
A) Develop revolutionary new ideas from the study of on-shell scattering amplitudes to address the current bottlenecks in the computation of multi-leg two loop amplitudes in QCD.
B) Develop highly efficient tools for NNLO predictions with multi-jet final states and perform precision phenomenological studies of jet dynamics at the LHC.
C) Lay groundwork for jet production beyond NNLO and build towards 1% perturbative accuracy.
JetDynamics will lead to a new understanding of scattering at hadron colliders and take LHC physics into a new precision era.
Summary
Precision tests at high energy colliders are an essential tool for gaining insight
into the nature of the Standard Model of particle physics and the fundamental interactions. The data currently being obtained by the LHC experiments will allow a large number of observables to be measured at a percent level accuracy. This data has the potential to probe deeper into the flaws of the Standard Model. However, the complexity of theoretical predictions using perturbative quantum field theory currently prevents many of these precision tests.
JetDynamics aims for a breakthrough in precision predictions for the measurements of Standard Model interactions through the study of the dynamics of multiple strongly interacting hadronic jets. Percent level predictions for 2 to 3 scattering processes involving the Higgs boson and electroweak vector bosons will allow a unique insight into fundamental properties of the Standard Model in the new high energy region probed by the LHC.
In order to achieve this goal a complete set of quantum corrections at next-to-next-to-leading order (NNLO) in perturbation theory are required. JetDynamics bridges the gap between mathematics physics and experimental collider physics and will develop a new generation of computational tools and methods} that will overcome current bottlenecks. The work program attacks this problem on two fronts:
A) Develop revolutionary new ideas from the study of on-shell scattering amplitudes to address the current bottlenecks in the computation of multi-leg two loop amplitudes in QCD.
B) Develop highly efficient tools for NNLO predictions with multi-jet final states and perform precision phenomenological studies of jet dynamics at the LHC.
C) Lay groundwork for jet production beyond NNLO and build towards 1% perturbative accuracy.
JetDynamics will lead to a new understanding of scattering at hadron colliders and take LHC physics into a new precision era.
Max ERC Funding
1 764 478 €
Duration
Start date: 2018-06-01, End date: 2023-05-31
Project acronym KAONLEPTON
Project Precision Lepton Flavour Conservation Tests in Kaon Decays
Researcher (PI) Evgueni Goudzovski
Host Institution (HI) THE UNIVERSITY OF BIRMINGHAM
Call Details Starting Grant (StG), PE2, ERC-2013-StG
Summary "A unique and innovative test of a cornerstone principle of the Standard Model of particle physics, the Lepton Favour (LF) conservation, is proposed in the framework of the NA62 experiment at CERN. The search for nine decay modes of the charged kaon and the neutral pion forbidden in the Standard Model by LF conservation will be carried out at a record sensitivity of one part in a trillion. Such sensitivity will be achieved due to the uniquely intense kaon beam that will become available to the experiment in 2014, as well as a range of novel particle detection technologies employed. The collection of the LF violating decay candidates will take place in ""parasitic"" mode alongside main NA62 data taking, which guarantees the feasibility, high data quality and cost-effectiveness. The project will bridge a significant research gap that has developed due to the absence of dedicated LF projects in the kaon sector, in sharp contrast with B-meson, lepton and neutrinoless double beta decay experiments. Any observed LF violating process will unambiguously point to physical phenomena beyond the Standard Model description, and will thus represent a major discovery. The Standard Model extensions that will be probed include those involving heavy Majorana neutrinos and R-parity breaking supersymmetry. Entire classes of new physics models will be confirmed, rigorously constrained or eliminated."
Summary
"A unique and innovative test of a cornerstone principle of the Standard Model of particle physics, the Lepton Favour (LF) conservation, is proposed in the framework of the NA62 experiment at CERN. The search for nine decay modes of the charged kaon and the neutral pion forbidden in the Standard Model by LF conservation will be carried out at a record sensitivity of one part in a trillion. Such sensitivity will be achieved due to the uniquely intense kaon beam that will become available to the experiment in 2014, as well as a range of novel particle detection technologies employed. The collection of the LF violating decay candidates will take place in ""parasitic"" mode alongside main NA62 data taking, which guarantees the feasibility, high data quality and cost-effectiveness. The project will bridge a significant research gap that has developed due to the absence of dedicated LF projects in the kaon sector, in sharp contrast with B-meson, lepton and neutrinoless double beta decay experiments. Any observed LF violating process will unambiguously point to physical phenomena beyond the Standard Model description, and will thus represent a major discovery. The Standard Model extensions that will be probed include those involving heavy Majorana neutrinos and R-parity breaking supersymmetry. Entire classes of new physics models will be confirmed, rigorously constrained or eliminated."
Max ERC Funding
1 617 546 €
Duration
Start date: 2014-01-01, End date: 2019-06-30
Project acronym LeviTeQ
Project Levitated Nanoparticles for Technology and Quantum Nanophysics: New frontiers in physics at the nanoscale.
Researcher (PI) James MILLEN
Host Institution (HI) KING'S COLLEGE LONDON
Call Details Starting Grant (StG), PE2, ERC-2018-STG
Summary Technology is continuously miniaturizing. As it reaches the nanoscale we face unique challenges, such as managing thermal. From the other direction, advances in the quantum physics of a few atoms, ions, and solid-state qubits mean that we increasingly wish to scale up quantum systems, or interface them with nanoscale devices.
Opto- and electro-mechanical (NEMS and MEMS) devices have been controlled at the quantum level in recent years, an amazing advance allowing even entanglement between light and mechanical motion. However, all such systems are plagued by unavoidable environmental contact, and energy dissipation through strain, limiting the potential of mechanical devices to participate in both classical and quantum technologies.
By levitating the mechanical element, these problems are overcome. LEVITEQ will, for the first time, cool the motion and rotation of tailor-made silicon particles, enabling full quantum level control. This ultra-low dissipation system offers exquisite force sensitivity, by driving the rotation of a levitated nanorod. LEVITEQ will pioneer the control of nanoparticles by electronic circuits, allowing simple technological integration in a room temperature environment. This all-electrical system will challenge existing quartz crystal oscillator technology.
LEVITEQ will explore new regimes of physics, by working in extreme vacuum, elucidating thermodynamics on the nanoscale. This research will pave the way for a levitated quantum object acting as a node in a quantum network, for coherent signal storage and conversion.
Summary
Technology is continuously miniaturizing. As it reaches the nanoscale we face unique challenges, such as managing thermal. From the other direction, advances in the quantum physics of a few atoms, ions, and solid-state qubits mean that we increasingly wish to scale up quantum systems, or interface them with nanoscale devices.
Opto- and electro-mechanical (NEMS and MEMS) devices have been controlled at the quantum level in recent years, an amazing advance allowing even entanglement between light and mechanical motion. However, all such systems are plagued by unavoidable environmental contact, and energy dissipation through strain, limiting the potential of mechanical devices to participate in both classical and quantum technologies.
By levitating the mechanical element, these problems are overcome. LEVITEQ will, for the first time, cool the motion and rotation of tailor-made silicon particles, enabling full quantum level control. This ultra-low dissipation system offers exquisite force sensitivity, by driving the rotation of a levitated nanorod. LEVITEQ will pioneer the control of nanoparticles by electronic circuits, allowing simple technological integration in a room temperature environment. This all-electrical system will challenge existing quartz crystal oscillator technology.
LEVITEQ will explore new regimes of physics, by working in extreme vacuum, elucidating thermodynamics on the nanoscale. This research will pave the way for a levitated quantum object acting as a node in a quantum network, for coherent signal storage and conversion.
Max ERC Funding
1 498 018 €
Duration
Start date: 2019-02-01, End date: 2024-01-31
Project acronym LHCDMTOP
Project Novel Dark Matter Searches with Top Quarks at the Large Hadron Collider
Researcher (PI) Daniel TOVEY
Host Institution (HI) THE UNIVERSITY OF SHEFFIELD
Call Details Advanced Grant (AdG), PE2, ERC-2015-AdG
Summary This project will address directly the two most important unanswered questions in particle physics: the Standard Model (SM) hierarchy problem and the nature of dark matter (DM). The SM was recently completed with the discovery of the Higgs boson at the Large Hadron Collider (LHC) in 2012. We know, however, that the SM cannot be the end of the story for fundamental physics, because it suffers from two major flaws: a lack of stability for the mass of the Higgs boson (the hierarchy problem), and a lack of a candidate for the invisible DM particles known to make up most of the matter in the universe. I will address both of these key problems of modern physics by searching at the LHC for new beyond the SM (BSM) partner states for the SM top quark decaying to new DM particles. The greatly increased quantities of data and world-record collision energies generated by the LHC in the next three years will provide an unprecedented opportunity to find such top partners. Confirmation of their existence would solve the hierarchy problem by providing a mechanism for stabilising the mass of the Higgs boson, while first observation of DM at the LHC would revolutionise our understanding of cosmology and provide a key pointer to the physics of the very early universe. Many leading BSM physics models predict the existence of both top partners and DM, and so this interdisciplinary project provides a unique opportunity to take the next major step forward in developing a unified theory of nature. I will focus on top partners which decay to a top quark and a DM particle, with the former decaying purely to jets and the latter escaping the detector unseen. I will use novel kinematic techniques developed by me to identify and characterise this signal in LHC data, and also accurately measure for the first time the dominant SM background process of associated production of top quarks and a Z boson, which is of great theoretical interest in its own right.
Summary
This project will address directly the two most important unanswered questions in particle physics: the Standard Model (SM) hierarchy problem and the nature of dark matter (DM). The SM was recently completed with the discovery of the Higgs boson at the Large Hadron Collider (LHC) in 2012. We know, however, that the SM cannot be the end of the story for fundamental physics, because it suffers from two major flaws: a lack of stability for the mass of the Higgs boson (the hierarchy problem), and a lack of a candidate for the invisible DM particles known to make up most of the matter in the universe. I will address both of these key problems of modern physics by searching at the LHC for new beyond the SM (BSM) partner states for the SM top quark decaying to new DM particles. The greatly increased quantities of data and world-record collision energies generated by the LHC in the next three years will provide an unprecedented opportunity to find such top partners. Confirmation of their existence would solve the hierarchy problem by providing a mechanism for stabilising the mass of the Higgs boson, while first observation of DM at the LHC would revolutionise our understanding of cosmology and provide a key pointer to the physics of the very early universe. Many leading BSM physics models predict the existence of both top partners and DM, and so this interdisciplinary project provides a unique opportunity to take the next major step forward in developing a unified theory of nature. I will focus on top partners which decay to a top quark and a DM particle, with the former decaying purely to jets and the latter escaping the detector unseen. I will use novel kinematic techniques developed by me to identify and characterise this signal in LHC data, and also accurately measure for the first time the dominant SM background process of associated production of top quarks and a Z boson, which is of great theoretical interest in its own right.
Max ERC Funding
1 584 650 €
Duration
Start date: 2016-05-01, End date: 2020-04-30
Project acronym LIGNINFIRST
Project The Lignin-First Approach for the Full Valorisation of Lignocellulosic Biomass
Researcher (PI) Roberto Rinaldi Sobrinho
Host Institution (HI) IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Call Details Consolidator Grant (CoG), PE8, ERC-2016-COG
Summary Early-stage Catalytic Conversion of Lignin (ECCL), or the ‘Lignin-First’ approach, constitutes an emerging multidisciplinary research field targeting the valorisation of lignin. ECCL involves the concurrent extraction and catalytic conversion of the lignin fragments released from plant biomass in a one-pot process. In this manner, ECCL benefits from the intrinsically high reactivity of the lignin oligomers, leading to further depolymerisation (via hydrogenolysis of ether linkages) and, most importantly, to the passivation of the intermediates (via hydrodeoxygenation of aldehyde and ketone groups), thus protecting the lignin fragments from recondensation. In short, this novel approach renders a high yield of mono-aromatic products (>60%) and highly delignified pulps, allowing for the full utilisation of lignocellulose. LIGNINFIRST objectives will be achieved by high-risk/high-gain research into: (1) understanding (and control over) the solvolytic release of lignin fragments; (2) advancing the molecular understanding of H-transfer reactions catalysed by sponge Ni catalysts to accelerate the discovery of catalytic methods for lignin valorisation, and; (3) reaction engineering of the interdependent processing steps for fractionation of the initial biomass feedstock (catalytic upstream biorefining) to the intended value-added products (catalytic downstream processing). The full impact of LIGNINFIRST will be realised by undertaking pioneering research at the border of Wood Chemistry, Catalysis and Reaction Engineering. The most significant anticipated outcome is a profound understanding of the synergy between deconstruction of lignin, occurring in the plant tissue throughout the ‘cooking process’, and ECCL. The new scientific insights that will emerge from the implementation of this proposal have the great potential for revolutionising the utilisation of lignin in biorefineries.
Summary
Early-stage Catalytic Conversion of Lignin (ECCL), or the ‘Lignin-First’ approach, constitutes an emerging multidisciplinary research field targeting the valorisation of lignin. ECCL involves the concurrent extraction and catalytic conversion of the lignin fragments released from plant biomass in a one-pot process. In this manner, ECCL benefits from the intrinsically high reactivity of the lignin oligomers, leading to further depolymerisation (via hydrogenolysis of ether linkages) and, most importantly, to the passivation of the intermediates (via hydrodeoxygenation of aldehyde and ketone groups), thus protecting the lignin fragments from recondensation. In short, this novel approach renders a high yield of mono-aromatic products (>60%) and highly delignified pulps, allowing for the full utilisation of lignocellulose. LIGNINFIRST objectives will be achieved by high-risk/high-gain research into: (1) understanding (and control over) the solvolytic release of lignin fragments; (2) advancing the molecular understanding of H-transfer reactions catalysed by sponge Ni catalysts to accelerate the discovery of catalytic methods for lignin valorisation, and; (3) reaction engineering of the interdependent processing steps for fractionation of the initial biomass feedstock (catalytic upstream biorefining) to the intended value-added products (catalytic downstream processing). The full impact of LIGNINFIRST will be realised by undertaking pioneering research at the border of Wood Chemistry, Catalysis and Reaction Engineering. The most significant anticipated outcome is a profound understanding of the synergy between deconstruction of lignin, occurring in the plant tissue throughout the ‘cooking process’, and ECCL. The new scientific insights that will emerge from the implementation of this proposal have the great potential for revolutionising the utilisation of lignin in biorefineries.
Max ERC Funding
1 999 756 €
Duration
Start date: 2017-03-01, End date: 2022-02-28
Project acronym MADPII
Project Multiscale Analysis and Design for Process Intensification and Innovation
Researcher (PI) Guy B.M.M. Marin
Host Institution (HI) UNIVERSITEIT GENT
Call Details Advanced Grant (AdG), PE8, ERC-2011-ADG_20110209
Summary The current pressures on the major industrial players have necessitated a more urgent push for increased productivity, process efficiency, and waste reduction; i.e. process intensification. Future sizable improvements in these entrenched industrial processes will require either completely novel production technologies, fundamental analysis/modeling methods, or a combination of both. This proposal aims to approach this challenge by using multiscale modeling and experimentation on three fronts: (1) detailed analysis of industrial processes to generate new fundamental chemical understanding, (2) multiscale modeling and evaluation of high-volume chemical processes using a multiscale approach and fundamental chemical understanding, and (3) show the practical applicability of the multiscale approach and use it to critically examine novel technologies in the context of industrial processes. The novel technology portion of this proposal will be focused around a class known as rotating bed reactors in a static geometry (RBR-SG). We will investigate three processes that could benefit from RBR-SG technology: (1) fast pyrolysis of biomass, (2) gasification of biomass, and (3) short contact time catalytic partial oxidation of light hydrocarbons. Experimental reactor and kinetic work and validated computational fluid dynamics (CFD) modeling of the process mentioned above will be used. We will construct two RBR-SG units; heat transfer, adsorption, and pyrolysis gas/solid experiments will be performed in one, while non-reacting flow tests will be performed in the other with other phase combinations. Detailed kinetic models will provide novel insights into the reaction dynamics and impact other research and technologies. The combination of kinetic and CFD models will clearly demonstrate the benefits of a multiscale approach, will definitively identify the process(es) benefitting most from RBR-SG technology, and will enable a first design of the RBR-SG based on our results.
Summary
The current pressures on the major industrial players have necessitated a more urgent push for increased productivity, process efficiency, and waste reduction; i.e. process intensification. Future sizable improvements in these entrenched industrial processes will require either completely novel production technologies, fundamental analysis/modeling methods, or a combination of both. This proposal aims to approach this challenge by using multiscale modeling and experimentation on three fronts: (1) detailed analysis of industrial processes to generate new fundamental chemical understanding, (2) multiscale modeling and evaluation of high-volume chemical processes using a multiscale approach and fundamental chemical understanding, and (3) show the practical applicability of the multiscale approach and use it to critically examine novel technologies in the context of industrial processes. The novel technology portion of this proposal will be focused around a class known as rotating bed reactors in a static geometry (RBR-SG). We will investigate three processes that could benefit from RBR-SG technology: (1) fast pyrolysis of biomass, (2) gasification of biomass, and (3) short contact time catalytic partial oxidation of light hydrocarbons. Experimental reactor and kinetic work and validated computational fluid dynamics (CFD) modeling of the process mentioned above will be used. We will construct two RBR-SG units; heat transfer, adsorption, and pyrolysis gas/solid experiments will be performed in one, while non-reacting flow tests will be performed in the other with other phase combinations. Detailed kinetic models will provide novel insights into the reaction dynamics and impact other research and technologies. The combination of kinetic and CFD models will clearly demonstrate the benefits of a multiscale approach, will definitively identify the process(es) benefitting most from RBR-SG technology, and will enable a first design of the RBR-SG based on our results.
Max ERC Funding
2 494 700 €
Duration
Start date: 2012-05-01, End date: 2017-04-30
Project acronym MAtrix
Project In silico and in vitro Models of Angiogenesis: unravelling the role of the extracellular matrix
Researcher (PI) Hans Pol S Van Oosterwyck
Host Institution (HI) KATHOLIEKE UNIVERSITEIT LEUVEN
Call Details Starting Grant (StG), PE8, ERC-2012-StG_20111012
Summary Angiogenesis, the formation of new blood vessels from the existing vasculature, is a process that is fundamental to normal tissue growth, wound repair and disease. The control of angiogenesis is of utmost importance for tissue regenerative therapies as well as cancer treatment, however this remains a challenge. The extracellular matrix (ECM) is a one of the key controlling factors of angiogenesis. The mechanisms through which the ECM exerts its influence are poorly understood. MAtrix will create unprecedented opportunities for unraveling the role of the ECM in angiogenesis. It will do so by creating a highly innovative, multiscale in silico model that provides quantitative, subcellular resolution on cell-matrix interaction, which is key to the understanding of cell migration. In this way, MAtrix goes substantially beyond the state of the art in terms of computational models of angiogenesis. It will integrate mechanisms of ECM-mediated cell migration and relate them to intracellular regulatory mechanisms of angiogenesis.
Apart from its innovation in terms of computational modelling, MAtrix’ impact is related to its interdisciplinarity, involving computer simulations and in vitro experiments. This will enable to investigate research hypotheses on the role of the ECM in angiogenesis that are generated by the in silico model. State of the art technologies (fluorescence microscopy, cell and ECM mechanics, biomaterials design) will be applied –in conjunction with the in silico model- to quantity cell-ECM mechanical interaction at a subcellular level and the dynamics of cell migration. In vitro experiments will be performed for a broad range of biomaterials and their characteristics. In this way, MAtrix will deliver a proof-of-concept that an in silico model can help in identifying and prioritising biomaterials characteristics, relevant for angiogenesis. MAtrix’ findings can have a major impact on the development of therapies that want to control the angiogenic response.
Summary
Angiogenesis, the formation of new blood vessels from the existing vasculature, is a process that is fundamental to normal tissue growth, wound repair and disease. The control of angiogenesis is of utmost importance for tissue regenerative therapies as well as cancer treatment, however this remains a challenge. The extracellular matrix (ECM) is a one of the key controlling factors of angiogenesis. The mechanisms through which the ECM exerts its influence are poorly understood. MAtrix will create unprecedented opportunities for unraveling the role of the ECM in angiogenesis. It will do so by creating a highly innovative, multiscale in silico model that provides quantitative, subcellular resolution on cell-matrix interaction, which is key to the understanding of cell migration. In this way, MAtrix goes substantially beyond the state of the art in terms of computational models of angiogenesis. It will integrate mechanisms of ECM-mediated cell migration and relate them to intracellular regulatory mechanisms of angiogenesis.
Apart from its innovation in terms of computational modelling, MAtrix’ impact is related to its interdisciplinarity, involving computer simulations and in vitro experiments. This will enable to investigate research hypotheses on the role of the ECM in angiogenesis that are generated by the in silico model. State of the art technologies (fluorescence microscopy, cell and ECM mechanics, biomaterials design) will be applied –in conjunction with the in silico model- to quantity cell-ECM mechanical interaction at a subcellular level and the dynamics of cell migration. In vitro experiments will be performed for a broad range of biomaterials and their characteristics. In this way, MAtrix will deliver a proof-of-concept that an in silico model can help in identifying and prioritising biomaterials characteristics, relevant for angiogenesis. MAtrix’ findings can have a major impact on the development of therapies that want to control the angiogenic response.
Max ERC Funding
1 497 400 €
Duration
Start date: 2013-04-01, End date: 2018-03-31
Project acronym MCATNNLO
Project High Precision Simulation of particle collisions at the LHC
Researcher (PI) Edward William Nigel Glover
Host Institution (HI) UNIVERSITY OF DURHAM
Call Details Advanced Grant (AdG), PE2, ERC-2013-ADG
Summary The recent discovery of a Higgs-boson like resonance at the Large Hadron Collider (LHC) at CERN is a major landmark in the quest to understand the fundamental nature of the Universe. Precise measurements of the properties of the new boson are now mandatory and must be reflected in a similar quest for higher precision from the theory side. We aim to meet this challenge by developing a theoretical framework together with suitable high-precision tools that will guarantee the continued success of the LHC programme.
The aim of this proposal is therefore to develop and establish a new standard of theoretical precision in the description of physical observables at the LHC and other particle collider experiments, thereby leading to a more precise extraction of fundamental physics parameters, such as the couplings of the Higgs boson to other fundamental particles. The necessary theoretical precision will be achieved by systematically including the next-to-next-to leading order (NNLO) corrections in the perturbative expansion in the relevant simulation tools, focusing on crucial
experimental benchmark processes.
The techniques and frameworks we will develop will be applicable to other processes and in particular, will be very relevant to searches for physics beyond the Standard Model, and in the further interpretation of any signals that would indicate such a discovery.
To achieve this ambitious goal, the PI will work very closely with a team of carefully chosen scientists with relevant overlapping and complementary expertise in precision calculations and event simulation: Professor Dr Thomas Gehrmann (University of Zürich), Professor Dr Aude Gehrmann-De Ridder (ETH Zürich) and Dr Frank Krauss (Durham University).
Summary
The recent discovery of a Higgs-boson like resonance at the Large Hadron Collider (LHC) at CERN is a major landmark in the quest to understand the fundamental nature of the Universe. Precise measurements of the properties of the new boson are now mandatory and must be reflected in a similar quest for higher precision from the theory side. We aim to meet this challenge by developing a theoretical framework together with suitable high-precision tools that will guarantee the continued success of the LHC programme.
The aim of this proposal is therefore to develop and establish a new standard of theoretical precision in the description of physical observables at the LHC and other particle collider experiments, thereby leading to a more precise extraction of fundamental physics parameters, such as the couplings of the Higgs boson to other fundamental particles. The necessary theoretical precision will be achieved by systematically including the next-to-next-to leading order (NNLO) corrections in the perturbative expansion in the relevant simulation tools, focusing on crucial
experimental benchmark processes.
The techniques and frameworks we will develop will be applicable to other processes and in particular, will be very relevant to searches for physics beyond the Standard Model, and in the further interpretation of any signals that would indicate such a discovery.
To achieve this ambitious goal, the PI will work very closely with a team of carefully chosen scientists with relevant overlapping and complementary expertise in precision calculations and event simulation: Professor Dr Thomas Gehrmann (University of Zürich), Professor Dr Aude Gehrmann-De Ridder (ETH Zürich) and Dr Frank Krauss (Durham University).
Max ERC Funding
1 941 144 €
Duration
Start date: 2014-03-01, End date: 2019-02-28