Project acronym ATOMKI-PPROCESS
Project Nuclear reaction studies relevant to the astrophysical p-process nucleosynthesis
Researcher (PI) György Gyürky
Host Institution (HI) Magyar Tudomanyos Akademia Atommagkutato Intezete
Call Details Starting Grant (StG), PE2, ERC-2007-StG
Summary The astrophysical p-process, the stellar production mechanism of the heavy, proton rich isotopes (p-isotopes), is one of the least studied processes in nucleosynthesis. The astrophysical site(s) for the p-process could not yet be clearly identified. In order to reproduce the natural abundances of the p-isotopes, the p-process models must take into account a huge nuclear reaction network. A precise knowledge of the rate of the nuclear reactions in this network is essential for a reliable abundance calculation and for a clear assignment of the astrophysical site(s). For lack of experimental data the nuclear physics inputs for the reaction networks are based on statistical model calculations. These calculations are largely untested in the mass and energy range relevant to the p-process and the uncertainties in the reaction rate values result in a correspondingly uncertain prediction of the p-isotope abundances. Therefore, experiments aiming at the determination of reaction rates for the p-process are of great importance. In this project nuclear reaction cross section measurements will be carried out in the mass and energy range of p-process to check the reliability of the statistical model calculations and to put the p-process models on a more reliable base. The accelerators of the Institute of Nuclear Research in Debrecen, Hungary provide the necessary basis for such studies. The p-process model calculations are especially sensitive to the rates of reactions involving alpha particles and heavy nuclei. Because of technical difficulties, so far there are practically no experimental data available on such reactions and the uncertainty in these reaction rates is presently one of the biggest contributions to the uncertainty of p-isotope abundance calculations. With the help of the ERC grant the alpha-induced reaction cross sections can be measured on heavy isotopes for the first time, which could contribute to a better understanding of the astrophysical p-process.
Summary
The astrophysical p-process, the stellar production mechanism of the heavy, proton rich isotopes (p-isotopes), is one of the least studied processes in nucleosynthesis. The astrophysical site(s) for the p-process could not yet be clearly identified. In order to reproduce the natural abundances of the p-isotopes, the p-process models must take into account a huge nuclear reaction network. A precise knowledge of the rate of the nuclear reactions in this network is essential for a reliable abundance calculation and for a clear assignment of the astrophysical site(s). For lack of experimental data the nuclear physics inputs for the reaction networks are based on statistical model calculations. These calculations are largely untested in the mass and energy range relevant to the p-process and the uncertainties in the reaction rate values result in a correspondingly uncertain prediction of the p-isotope abundances. Therefore, experiments aiming at the determination of reaction rates for the p-process are of great importance. In this project nuclear reaction cross section measurements will be carried out in the mass and energy range of p-process to check the reliability of the statistical model calculations and to put the p-process models on a more reliable base. The accelerators of the Institute of Nuclear Research in Debrecen, Hungary provide the necessary basis for such studies. The p-process model calculations are especially sensitive to the rates of reactions involving alpha particles and heavy nuclei. Because of technical difficulties, so far there are practically no experimental data available on such reactions and the uncertainty in these reaction rates is presently one of the biggest contributions to the uncertainty of p-isotope abundance calculations. With the help of the ERC grant the alpha-induced reaction cross sections can be measured on heavy isotopes for the first time, which could contribute to a better understanding of the astrophysical p-process.
Max ERC Funding
750 000 €
Duration
Start date: 2008-07-01, End date: 2013-06-30
Project acronym COSMOLOCALISM
Project Design Global, Manufacture Local: Assessing the Practices, Innovation, and Sustainability Potential of an Emerging Mode of Production
Researcher (PI) Vasileios KOSTAKIS
Host Institution (HI) TALLINNA TEHNIKAULIKOOL
Call Details Starting Grant (StG), SH2, ERC-2018-STG
Summary COSMOLOCALISM will document, analyse, test, evaluate, and create awareness about an emerging mode of production, based on the confluence of the digital commons (e.g. open knowledge and design) with local manufacturing and automation technologies (from 3D printing and CNC machines to low-tech tools and crafts). This convergence could catalyse the transition to new inclusive and circular productive models, such as the “design global, manufacture local” (DGML) model.
DGML describes the processes through which design is developed as a global digital commons, whereas the manufacturing takes place locally, through shared infrastructures and with local biophysical conditions in mind. DGML seems to form economies of scope that promote sustainability and open innovation while celebrating new ways of cooperation. However, such claims rest on thin conceptual and empirical foundations.
COSMOLOCALISM is a multiphase, pilot-driven investigation of the DGML phenomenon that seeks to understand relevant organisational models, their evolution, and their broader political economy/ecology and policy implications. Through the lens of diverse case studies and participatory action research, the conditions under which the DGML model thrives will be explored.
COSMOLOCALISM has three concurrent streams: practices; innovation; and sustainability. First, DGML practices will be studied, patterns will be recognised and their form, function, cultural values, and governance structure will be determined. Second, the relevant open innovation ecosystems and their potential to reorient design and manufacturing practices will be examined. Third, selected DGML products will be evaluated from an environmental sustainability perspective, involving both qualitative and quantitative methods. The interdisciplinary nature of COSMOLOCALISM will explore new horizons to substantively improve our understanding of how we could do “more” and “better” with less.
Summary
COSMOLOCALISM will document, analyse, test, evaluate, and create awareness about an emerging mode of production, based on the confluence of the digital commons (e.g. open knowledge and design) with local manufacturing and automation technologies (from 3D printing and CNC machines to low-tech tools and crafts). This convergence could catalyse the transition to new inclusive and circular productive models, such as the “design global, manufacture local” (DGML) model.
DGML describes the processes through which design is developed as a global digital commons, whereas the manufacturing takes place locally, through shared infrastructures and with local biophysical conditions in mind. DGML seems to form economies of scope that promote sustainability and open innovation while celebrating new ways of cooperation. However, such claims rest on thin conceptual and empirical foundations.
COSMOLOCALISM is a multiphase, pilot-driven investigation of the DGML phenomenon that seeks to understand relevant organisational models, their evolution, and their broader political economy/ecology and policy implications. Through the lens of diverse case studies and participatory action research, the conditions under which the DGML model thrives will be explored.
COSMOLOCALISM has three concurrent streams: practices; innovation; and sustainability. First, DGML practices will be studied, patterns will be recognised and their form, function, cultural values, and governance structure will be determined. Second, the relevant open innovation ecosystems and their potential to reorient design and manufacturing practices will be examined. Third, selected DGML products will be evaluated from an environmental sustainability perspective, involving both qualitative and quantitative methods. The interdisciplinary nature of COSMOLOCALISM will explore new horizons to substantively improve our understanding of how we could do “more” and “better” with less.
Max ERC Funding
1 017 275 €
Duration
Start date: 2019-01-01, End date: 2022-12-31
Project acronym EAST-WEST
Project Vernacular religion on the boundary of Eastern and Western Christianity: continuity, changes and interactions
Researcher (PI) Zsoltné Csalog
Host Institution (HI) MAGYAR TUDOMANYOS AKADEMIA BOLCSESZETTUDOMANYI KUTATOKOZPONT
Call Details Advanced Grant (AdG), SH2, ERC-2012-ADG_20120411
Summary This interdisciplinary research project, relying on mutually complementary historical, anthropological and folklore investigations, will examine continuities and transformations in vernacular religion in the border-zone between Eastern and Western Christianity. The project will have three foci: 1) the role of the religious worldview and norms in past and present communities; 2) change and religious modernisation including the intertwining of the breaking up of the traditional worldview and the appearance of consumer-type attitudes of New Age religiosity; 3) the role of religion in identity formation and the emergence of religious pluralism and co-operation as well as of religious antagonism and conflict between different denominations and nationalities in the region. Members of the project will study these questions in Hungarian, Romanian, Serbian, Ukrainian and Croatian communities of mixed religion. Thematically the research will be organised around exploring symbolic exchange relationships (demonology and witchcraft) sacred communication (shrines, visions, miracles, saints) and healing using both historical sources and contemporary anthropological field work.
The project builds on two previous long-term historical/folkloristic research projects led by PI Éva Pócs and will expand and complement their findings through contemporary anthropological field research and continued archival work. Integrating the results of the current and earlier projects through an innovative electronic document collection, embedded in a geographical information system, will enhance the impact of both sets of materials.
The research will bring us closer to understanding a) inter-religious relationships between Catholic, Protestant and Orthodox believers, b) problems of national identity underlying religious antagonisms, and c) how religious and cultural border zones separate and unite, generate conflict and create mutual understanding, potentially promoting peaceful co-existence.
Summary
This interdisciplinary research project, relying on mutually complementary historical, anthropological and folklore investigations, will examine continuities and transformations in vernacular religion in the border-zone between Eastern and Western Christianity. The project will have three foci: 1) the role of the religious worldview and norms in past and present communities; 2) change and religious modernisation including the intertwining of the breaking up of the traditional worldview and the appearance of consumer-type attitudes of New Age religiosity; 3) the role of religion in identity formation and the emergence of religious pluralism and co-operation as well as of religious antagonism and conflict between different denominations and nationalities in the region. Members of the project will study these questions in Hungarian, Romanian, Serbian, Ukrainian and Croatian communities of mixed religion. Thematically the research will be organised around exploring symbolic exchange relationships (demonology and witchcraft) sacred communication (shrines, visions, miracles, saints) and healing using both historical sources and contemporary anthropological field work.
The project builds on two previous long-term historical/folkloristic research projects led by PI Éva Pócs and will expand and complement their findings through contemporary anthropological field research and continued archival work. Integrating the results of the current and earlier projects through an innovative electronic document collection, embedded in a geographical information system, will enhance the impact of both sets of materials.
The research will bring us closer to understanding a) inter-religious relationships between Catholic, Protestant and Orthodox believers, b) problems of national identity underlying religious antagonisms, and c) how religious and cultural border zones separate and unite, generate conflict and create mutual understanding, potentially promoting peaceful co-existence.
Max ERC Funding
2 079 485 €
Duration
Start date: 2013-09-01, End date: 2018-08-31
Project acronym GENECLOCKS
Project Reconstructing a dated tree of life using phylogenetic incongruence
Researcher (PI) Gergely Janos SZOLLOSI
Host Institution (HI) EOTVOS LORAND TUDOMANYEGYETEM
Call Details Starting Grant (StG), LS8, ERC-2016-STG
Summary With the advent of genome-scale sequencing, molecular phylogeny, which reconstructs gene trees from homologous sequences, has reached an impasse. Instead of answering open questions, new genomes have reignited old debates. The problem is clear, gene trees are not species trees, each is the unique result of series of evolutionary events. If, however, we model these differences in the context of a common species tree, we can access a wealth of information on genome evolution and the diversification of species that is not available to traditional methods. For example, as horizontal gene transfer (HGT) can only occur between coexisting species, HGTs provide information on the order of speciations. When HGT is rare, lineage sorting can generate incongruence between gene trees and the dating problem can be formulated in terms of biologically meaningful parameters (such as population size), that are informative on the rate of evolution and hence invaluable to molecular dating.
My first goal is to develop methods that systematically extract information on the pattern and timing of genomic evolution by explaining differences between gene trees. This will allow us to, for the first time, reconstruct a dated tree of life from genome-scale data. We will use parallel programming to maximise the number of genomes analysed.
My second goal is to apply these methods to open problems, e.g.: i) to resolve the timing of microbial evolution and its relationship to Earth history, where the extreme paucity of fossils limits the use of molecular dating methods, by using HGT events as “molecular fossils”; ii) to reconstruct rooted phylogenies from complete genomes and harness phylogenetic incongruence to answer long standing questions, such as the of diversification of animals or the position of eukaryotes among archaea; and iii) for eukaryotic groups such as Fungi, where evidence of significant amounts of HGT is emerging our methods will also allow the quantification of the extent of HGT.
Summary
With the advent of genome-scale sequencing, molecular phylogeny, which reconstructs gene trees from homologous sequences, has reached an impasse. Instead of answering open questions, new genomes have reignited old debates. The problem is clear, gene trees are not species trees, each is the unique result of series of evolutionary events. If, however, we model these differences in the context of a common species tree, we can access a wealth of information on genome evolution and the diversification of species that is not available to traditional methods. For example, as horizontal gene transfer (HGT) can only occur between coexisting species, HGTs provide information on the order of speciations. When HGT is rare, lineage sorting can generate incongruence between gene trees and the dating problem can be formulated in terms of biologically meaningful parameters (such as population size), that are informative on the rate of evolution and hence invaluable to molecular dating.
My first goal is to develop methods that systematically extract information on the pattern and timing of genomic evolution by explaining differences between gene trees. This will allow us to, for the first time, reconstruct a dated tree of life from genome-scale data. We will use parallel programming to maximise the number of genomes analysed.
My second goal is to apply these methods to open problems, e.g.: i) to resolve the timing of microbial evolution and its relationship to Earth history, where the extreme paucity of fossils limits the use of molecular dating methods, by using HGT events as “molecular fossils”; ii) to reconstruct rooted phylogenies from complete genomes and harness phylogenetic incongruence to answer long standing questions, such as the of diversification of animals or the position of eukaryotes among archaea; and iii) for eukaryotic groups such as Fungi, where evidence of significant amounts of HGT is emerging our methods will also allow the quantification of the extent of HGT.
Max ERC Funding
1 453 542 €
Duration
Start date: 2017-07-01, End date: 2022-06-30
Project acronym INTLAWRUSSIA
Project International Law and Non-liberal States: The Doctrine and Application of International Law in the Russian Federation
Researcher (PI) Lauri Mälksoo
Host Institution (HI) TARTU ULIKOOL
Call Details Starting Grant (StG), SH2, ERC-2009-StG
Summary The central research question of our project is: what impact does the increasingly non-liberal orientation of the government of the Russian Federation have on the Russian doctrine and practice of international law? As the West and Russia hope to further build their relationship on international law, is it still the same international law that they are talking about? We aim to provide systematic empirical evidence on the use and conceptualization of international law in the Russian Federation. But we intend to go further than that. The project has also a wider theoretical ambition since we intend to analyze the situation in Russia as an example of something beyond Russia itself, namely from the viewpoint of the question of how non-liberal States understand and practice international law. Whether non-liberal States 'behave worse' in respect to international law than liberal States is one of the most important debates in the post-Cold War international legal theory. To combine these two questions - Russia and how non-liberal States relate to international law - promises ground-breaking new insights. Our method includes, beside obvious classical tools of international legal research, using IR theories of constructivism and liberalism. Moreover, we will conduct interviews with Russian judges, politicians and legal academicians in order to get a more nuanced and realistic view on the conceptualization and use of international law in Russia. Besides the PI, the research team includes two post-doc scholars at the Faculty of Law of Tartu University. Three doctoral student positions are also foreseen in the project.
Summary
The central research question of our project is: what impact does the increasingly non-liberal orientation of the government of the Russian Federation have on the Russian doctrine and practice of international law? As the West and Russia hope to further build their relationship on international law, is it still the same international law that they are talking about? We aim to provide systematic empirical evidence on the use and conceptualization of international law in the Russian Federation. But we intend to go further than that. The project has also a wider theoretical ambition since we intend to analyze the situation in Russia as an example of something beyond Russia itself, namely from the viewpoint of the question of how non-liberal States understand and practice international law. Whether non-liberal States 'behave worse' in respect to international law than liberal States is one of the most important debates in the post-Cold War international legal theory. To combine these two questions - Russia and how non-liberal States relate to international law - promises ground-breaking new insights. Our method includes, beside obvious classical tools of international legal research, using IR theories of constructivism and liberalism. Moreover, we will conduct interviews with Russian judges, politicians and legal academicians in order to get a more nuanced and realistic view on the conceptualization and use of international law in Russia. Besides the PI, the research team includes two post-doc scholars at the Faculty of Law of Tartu University. Three doctoral student positions are also foreseen in the project.
Max ERC Funding
500 000 €
Duration
Start date: 2009-09-01, End date: 2014-08-31
Project acronym Multicellularity
Project The genetic basis of the convergent evolution of fungal multicellularity
Researcher (PI) Laszlo NAGY
Host Institution (HI) MAGYAR TUDOMANYOS AKADEMIA SZEGEDIBIOLOGIAI KUTATOKOZPONT
Call Details Starting Grant (StG), LS8, ERC-2017-STG
Summary The evolution of multicellularity (MC) has been one of the major transitions in the history of life. Despite immense interest in its evolutionary origins, the genomic changes leading to the emergence of MC, especially that of complex MC (differentiated 3-dimensional structures) are poorly known. Previous comparative genomics projects aiming to understand the genetic bases of MC in one way or another relied on gene content-based analyses. However, a pattern emerging from these studies is that gene content provides only an incomplete explanation for the evolution of MC even at ancient timescales. We hypothesize that besides gene duplications, changes to cis-regulatory elements and gene expression patterns (including protein isoforms) have significantly contributed to the evolution of MC. To test this hypothesis, we will deploy a combination of computational methods, phylogenomics, comparative transcriptomics and genome-wide assays of regulatory elements. Our research focuses on fungi as a model system, where complex MC evolved convergently and in subsequent two steps. Fungi are ideal models to tackle this question for several reasons: a) multicellularity in fungi evolved multiple times, b) there are rich genomic resources (>500 complete genomes), c) complex multicellular structures can be routinely grown in the lab and d) genetic manipulations are feasible for several cornerstone species. We set out to examine which genes participate in the building of simple and complex multicellular structures and whether the evolution of regulome complexity and gene expression patterns can explain the evolution of MC better than can traditionally assayed sources of genetic innovations (e.g. gene duplications). Ultimately, our goal is to reach a general synthesis on the genetic bases of the evolution of MC and that of organismal complexity.
Summary
The evolution of multicellularity (MC) has been one of the major transitions in the history of life. Despite immense interest in its evolutionary origins, the genomic changes leading to the emergence of MC, especially that of complex MC (differentiated 3-dimensional structures) are poorly known. Previous comparative genomics projects aiming to understand the genetic bases of MC in one way or another relied on gene content-based analyses. However, a pattern emerging from these studies is that gene content provides only an incomplete explanation for the evolution of MC even at ancient timescales. We hypothesize that besides gene duplications, changes to cis-regulatory elements and gene expression patterns (including protein isoforms) have significantly contributed to the evolution of MC. To test this hypothesis, we will deploy a combination of computational methods, phylogenomics, comparative transcriptomics and genome-wide assays of regulatory elements. Our research focuses on fungi as a model system, where complex MC evolved convergently and in subsequent two steps. Fungi are ideal models to tackle this question for several reasons: a) multicellularity in fungi evolved multiple times, b) there are rich genomic resources (>500 complete genomes), c) complex multicellular structures can be routinely grown in the lab and d) genetic manipulations are feasible for several cornerstone species. We set out to examine which genes participate in the building of simple and complex multicellular structures and whether the evolution of regulome complexity and gene expression patterns can explain the evolution of MC better than can traditionally assayed sources of genetic innovations (e.g. gene duplications). Ultimately, our goal is to reach a general synthesis on the genetic bases of the evolution of MC and that of organismal complexity.
Max ERC Funding
1 486 500 €
Duration
Start date: 2018-01-01, End date: 2022-12-31
Project acronym QCDTHERMO
Project QCD thermodynamics on the lattice
Researcher (PI) Sándor Katz
Host Institution (HI) EOTVOS LORAND TUDOMANYEGYETEM
Call Details Starting Grant (StG), PE2, ERC-2007-StG
Summary Quantum Chromodynamics (QCD) at finite temperature and non-zero density describes phenomena relevant to the early universe and heavy-ion collisions. The applicability of perturbation theory is limited to large temperatures and densities. We plan to use lattice simulations to study QCD thermodynamics. There are different regularizations of QCD on the lattice. The computationally most effective one is the staggered formulation, while Wilson or chiral fermions are theoretically more established. We have to distinguish studies at vanishing baryon densities from the ones concerning non-zero density. At vanishing densities the order of the QCD transition between the hadronic phase and the quark-gluon plasma was studied using staggered fermions. In the physical, continuum limit the transition was found to be a crossover. The transition temperature has also been determined. These studies should be and will be extended using Wilson and chiral fermions. This way the staggered results can be checked. At non-vanishing densities direct lattice simulations are prohibited by the infamous sign problem. Recently the multi-parameter reweighting method was developed to study moderate densities using simulations at zero baryon density. The phase diagram as well as the critical point of QCD was determined using staggered fermions with a single lattice resolution. We plan to extend these studies in two ways. In the first step finer lattices will be studied with staggered fermions and a continuum extrapolation will be attempted. In the second step Wilson and possibly chiral fermions will be used. At large densities where the sign problem is the most severe the density of states method will be used. Based on our experience with PC clusters we will build a new, high performance cluster to achieve these goals. The establishment of a strong new research group certainly will improve the competitivity of the European lattice community.
Summary
Quantum Chromodynamics (QCD) at finite temperature and non-zero density describes phenomena relevant to the early universe and heavy-ion collisions. The applicability of perturbation theory is limited to large temperatures and densities. We plan to use lattice simulations to study QCD thermodynamics. There are different regularizations of QCD on the lattice. The computationally most effective one is the staggered formulation, while Wilson or chiral fermions are theoretically more established. We have to distinguish studies at vanishing baryon densities from the ones concerning non-zero density. At vanishing densities the order of the QCD transition between the hadronic phase and the quark-gluon plasma was studied using staggered fermions. In the physical, continuum limit the transition was found to be a crossover. The transition temperature has also been determined. These studies should be and will be extended using Wilson and chiral fermions. This way the staggered results can be checked. At non-vanishing densities direct lattice simulations are prohibited by the infamous sign problem. Recently the multi-parameter reweighting method was developed to study moderate densities using simulations at zero baryon density. The phase diagram as well as the critical point of QCD was determined using staggered fermions with a single lattice resolution. We plan to extend these studies in two ways. In the first step finer lattices will be studied with staggered fermions and a continuum extrapolation will be attempted. In the second step Wilson and possibly chiral fermions will be used. At large densities where the sign problem is the most severe the density of states method will be used. Based on our experience with PC clusters we will build a new, high performance cluster to achieve these goals. The establishment of a strong new research group certainly will improve the competitivity of the European lattice community.
Max ERC Funding
1 300 000 €
Duration
Start date: 2008-07-01, End date: 2014-03-31
Project acronym resistance evolution
Project Bacterial evolution of hypersensitivity and resistance against antimicrobial peptides
Researcher (PI) Csaba Pal
Host Institution (HI) MAGYAR TUDOMANYOS AKADEMIA SZEGEDIBIOLOGIAI KUTATOKOZPONT
Call Details Consolidator Grant (CoG), LS8, ERC-2014-CoG
Summary Evolution of resistance towards a single drug simultaneously increases (cross-resistance) or decreases (collateral sensitivity) fitness to multiple other antimicrobial agents. The molecular mechanisms driving cross-resistance are relatively well described, but it remains largely unclear how frequently does genetic adaptation to a single drug increase the sensitivity to others and what the underlying molecular mechanisms of collateral sensitivity are. This proposal focuses on studying the bacterial evolution of resistance and collateral sensitivity against antimicrobial peptides (AMPs). Beyond their modulatory roles in the immune system, these naturally occurring peptides provide protection against pathogenic microbes, and are considered as promising novel alternatives to traditional antibiotics. However, there are concerns that evolution against therapeutic AMPs can readily develop and as a by-product this might compromise natural immunity. Our knowledge of these issues is limited due to the shortage of systematic evolutionary studies. Therefore, the three central questions we address are: Do bacteria resistant to multiple antibiotics become hypersensitive to certain antimicrobial peptides? What are the evolutionary mechanisms leading to AMP resistance and to what extent does this process induce cross-resistance/collateral sensitivity against other drugs? Last, are these evolutionary trade-offs predictable based on chemical and functional peptide properties? To investigate these issues rigorously, we integrate tools of laboratory evolution, high-throughput phenotypic assays, functional genomics, and computational systems biology. Our project will provide an insight into the evolutionary mechanisms that drive cross-resistance and collateral sensitivities with the aim to explore the vulnerable points of resistant bacteria. Another goal is to provide guidelines for the future design of antimicrobial peptides with desirable properties against bacterial pathogens.
Summary
Evolution of resistance towards a single drug simultaneously increases (cross-resistance) or decreases (collateral sensitivity) fitness to multiple other antimicrobial agents. The molecular mechanisms driving cross-resistance are relatively well described, but it remains largely unclear how frequently does genetic adaptation to a single drug increase the sensitivity to others and what the underlying molecular mechanisms of collateral sensitivity are. This proposal focuses on studying the bacterial evolution of resistance and collateral sensitivity against antimicrobial peptides (AMPs). Beyond their modulatory roles in the immune system, these naturally occurring peptides provide protection against pathogenic microbes, and are considered as promising novel alternatives to traditional antibiotics. However, there are concerns that evolution against therapeutic AMPs can readily develop and as a by-product this might compromise natural immunity. Our knowledge of these issues is limited due to the shortage of systematic evolutionary studies. Therefore, the three central questions we address are: Do bacteria resistant to multiple antibiotics become hypersensitive to certain antimicrobial peptides? What are the evolutionary mechanisms leading to AMP resistance and to what extent does this process induce cross-resistance/collateral sensitivity against other drugs? Last, are these evolutionary trade-offs predictable based on chemical and functional peptide properties? To investigate these issues rigorously, we integrate tools of laboratory evolution, high-throughput phenotypic assays, functional genomics, and computational systems biology. Our project will provide an insight into the evolutionary mechanisms that drive cross-resistance and collateral sensitivities with the aim to explore the vulnerable points of resistant bacteria. Another goal is to provide guidelines for the future design of antimicrobial peptides with desirable properties against bacterial pathogens.
Max ERC Funding
1 846 250 €
Duration
Start date: 2015-10-01, End date: 2021-09-30
Project acronym Sip-Vol+
Project Stress-Induced Plant Volatiles in Biosphere-Atmosphere System
Researcher (PI) Ülo Niinemets
Host Institution (HI) EESTI MAAULIKOOL
Call Details Advanced Grant (AdG), LS8, ERC-2012-ADG_20120314
Summary Vegetation forms a key interface between Earth surface and atmosphere. The important role of vegetation carbon, water and energy exchanges is well established, but the overall impact of plant trace gas (VOC) emission for large-scale Earth processes is poorly understood. Although it is widely accepted that VOCs play major roles in the formation of ozone, secondary organic aerosols (SOA) and cloud condensation nuclei (CNN) with potentially profound impacts on air quality and Earth radiative balance, the research has so far focused only on constitutive emissions from species considered “emitters”. However, differently from constitutive VOCs emitted only by certain species, all plant species can be triggered to emit induced VOCs under abiotic and biotic stress. So far, induced high-reactivity VOCs are not considered in global VOC budget, and thus, this proposal tests the key assumption that VOC emissions worldwide have been vastly underestimated. As global change is resulting in higher level of stress in Earth ecosystems, the relevance of induced emissions is further expected to gain in importance. The current project has the overall objective to evaluate the effect of plant-generated VOC emissions on air composition and environment under global change, with particular emphasis on the role of VOCs induced in response to environmental stress. The study first quantifies the VOC production vs. stress severity relationships across species with differing stress tolerance and advances and parameterizes the qualitative induced VOC model developed by PI. The novel quantitative model is further verified by flux measurements and scaled up to regional and global scales to assess the contribution of induced emissions to overall VOC budget, and study the feedbacks between stress, ozone, SOA and CNN formation and the Earth climate using an hierarchy of available models. This highly cross-disciplinary project is expected to result in key contributions in two research fields of major significance: plant stress tolerance from molecules to globe and the role of vegetation component in atmospheric reactivity and Earth climate. The first part of the study provides fundamental insight into the stress responsiveness of plants with differing tolerance to environmental limitations, extending “leaf economics spectrum”, a hotspot of current plant ecology research. The second part provides quantitative information on large-scale importance of plant VOCs in globally changing climates with major relevance for understanding the role of plants in the Earth’s large scale processes.
Summary
Vegetation forms a key interface between Earth surface and atmosphere. The important role of vegetation carbon, water and energy exchanges is well established, but the overall impact of plant trace gas (VOC) emission for large-scale Earth processes is poorly understood. Although it is widely accepted that VOCs play major roles in the formation of ozone, secondary organic aerosols (SOA) and cloud condensation nuclei (CNN) with potentially profound impacts on air quality and Earth radiative balance, the research has so far focused only on constitutive emissions from species considered “emitters”. However, differently from constitutive VOCs emitted only by certain species, all plant species can be triggered to emit induced VOCs under abiotic and biotic stress. So far, induced high-reactivity VOCs are not considered in global VOC budget, and thus, this proposal tests the key assumption that VOC emissions worldwide have been vastly underestimated. As global change is resulting in higher level of stress in Earth ecosystems, the relevance of induced emissions is further expected to gain in importance. The current project has the overall objective to evaluate the effect of plant-generated VOC emissions on air composition and environment under global change, with particular emphasis on the role of VOCs induced in response to environmental stress. The study first quantifies the VOC production vs. stress severity relationships across species with differing stress tolerance and advances and parameterizes the qualitative induced VOC model developed by PI. The novel quantitative model is further verified by flux measurements and scaled up to regional and global scales to assess the contribution of induced emissions to overall VOC budget, and study the feedbacks between stress, ozone, SOA and CNN formation and the Earth climate using an hierarchy of available models. This highly cross-disciplinary project is expected to result in key contributions in two research fields of major significance: plant stress tolerance from molecules to globe and the role of vegetation component in atmospheric reactivity and Earth climate. The first part of the study provides fundamental insight into the stress responsiveness of plants with differing tolerance to environmental limitations, extending “leaf economics spectrum”, a hotspot of current plant ecology research. The second part provides quantitative information on large-scale importance of plant VOCs in globally changing climates with major relevance for understanding the role of plants in the Earth’s large scale processes.
Max ERC Funding
2 259 366 €
Duration
Start date: 2013-05-01, End date: 2018-04-30
