ERC FUNDED PROJECTS

Current IT research does not respond to the world's multi-cultural reality. It could be argued that we are imposing the paradigms of our market-driven western culture also on IT and that current IT research results will only facilitate the access of a small part of the world’s information to a small part of the world's population. Most IT research is being carried out with a western centred approach and as a result, our data models, cognition models, user models, interaction models, ontologies, … are all culturally biased. This fact is quite evident in music information research, since, despite the world's richness in musical cultures, most of the research is centred on CDs and metadata of our western commercial music. CompMusic wants to break this huge research bias. By approaching musical information modelling from a multicultural perspective it aims at advancing our state of the art while facilitating the discovery and reuse of the music produced outside the western commercial context. But the development of computational models to address the world’s music information richness cannot be done from the West looking out; we have to involve researchers and musical experts immersed in the different cultures. Their contribution is fundamental to develop the appropriate multicultural musicological and cognitive frameworks from which we should then carry our research on finding appropriate musical features, ontologies, data representations, user interfaces and user centred approaches. CompMusic will investigate some of the most consolidated non-western classical music traditions, Indian (hindustani, carnatic), Turkish-Arab (ottoman, andalusian), and Chinese (han), developing the needed computational models to bring their music into the current globalized information framework. Using these music cultures as case studies, cultures that are alive and have a strong influence in current society, we can develop rich information models that can take advantage of the existing information coming from musicological and cultural studies, from mature performance practice traditions and from active social contexts. With this approach we aim at challenging the current western centred information paradigms, advance our IT research, and contribute to our rich multicultural society.

2 443 200 €

Start date: 2011-07-01, End date: 2017-06-30

"The Environmental Justice Atlas (www.ejatlas.org) is a global database built by us, drawing on activist and academic knowledge. It maps 1500 conflicts. To improve geographical and thematic coverage it will grow to 3000 by 2019. It systematizes conflicts across 100+ fields documenting the commodities at stake, the actors involved, impacts, forms of mobilizations and outcomes allowing analyses that will lead to a general theory of ecological distribution conflicts. We shall research the links between changes in social metabolism and resource extraction conflicts at the “commodity frontiers”. Also other questions in political ecology and social movement theory such as the effectiveness of direct action by grassroots protesters compared to institutional forms of contention. Does the involvement of different actors, e.g. indigenous groups, relate to different conflict outcomes? How often does the IUCN ally itself to ""the environmentalism of the poor""? Do mobilizations and outcomes vary across sectors (mining, hydroelectric dams, waste incinerators) according to project differences in economic and biophysical dimensions, environmental and health risks? Are conflicts on point resources (mining, oil extraction) regularly different from conflicts in agriculture? Can we track networked resistances against Western companies, compared to those from China or other countries? Resistance to environmental damage has brought into being many local and some international EJOs pushing for alternative social transformations. We shall study the Vocabulary of Environmental Justice they deploy: climate justice, water justice, food sovereignty, biopiracy, sacrifice zones, and other terms specific to countries: Chinese “cancer villages”, Indian “sand mafias”, Brazilian “green deserts” (eucalyptus plantations). Finally, are there signs of an alliance between the Global Environmental Justice Movement and the small European movement for “prosperity without growth”, décroissance, Post-Wachstum?"

1 910 811 €

Start date: 2016-06-01, End date: 2021-05-31

Protein folding and function is a perfect arena towards growing the grassroots of quantitative and synthetic biology. This is so because all cellular processes controlled by proteins can ultimately be traced back to physico-chemical properties encoded in their aminoacid sequences. MOLRHEOSTAT is framed within these goals, focusing on the investigation of novel connections between protein folding and function via a multidisciplinary approach that combines experiment (single molecule spectroscopy, high-resolution NMR, protein engineering and design), theory and computer simulations. Conventionally, proteins are portrayed as conformational switches that fold and function by flipping between an on-state (native, active) and an off-state (inactive, unfolded) in response to stimuli. However, last years have witnessed the discovery of protein modules that undergo continuous conformational changes upon unfolding (downhill folding). MOLRHEOSTAT aims at investigating the functional and technological implications of downhill folding. The goal is to determine whether downhill folding modules can be exploited to build conformational rheostats; that is, proteins that continuously modulate a signal or response at the single molecule level by tuning their folding conformational ensemble. Conformational rheostats could open a new realm of applications as synthetic biomolecular devices as well as regulatory mechanisms for controlling complex biochemical processes carried out by macromolecular assemblies. These ideas will be explored on two specific objectives: 1) Implementation of a general approach for building high-performance, ultrafast, single-molecule sensors based on downhill protein folding modules. 2) Analysis of the roles of conformational rheostats in the regulation of three fundamental processes in molecular biology (coordination in protein networks, DNA sliding and homing-to-target of transcription factors, and molecular springs in macromolecular assemblies).

2 290 319 €

Start date: 2013-05-01, End date: 2018-04-30

Through evolution, cells have developed the exquisite ability to sense, transduce and integrate mechanical and biochemical signals (i.e. mechanobiology) to generate appropriate responses. These key events are rooted at the molecular and nanoscale levels, a size regime difficult to access, hindering our progress towards mechanistic understanding of mechanobiology. Recent evidence from my Lab (and others) shows that the lateral nanoscale organisation of mechanosensitive membrane receptors and signalling molecules is crucial for cell function. Yet, current models of mechanosensing are based on force-induced molecular conformations, completely overlooking the chief role of mechanical forces on the nanoscale spatiotemporal organisation of the plasma membrane. The GOAL of NANO-MEMEC is to provide mechanistic understanding on the role of mechanical stimuli in the spatiotemporal nanoarchitecture of adhesion signalling platforms at the cell membrane. To overcome the technical challenges of probing these processes at the relevant spatiotemporal scales, I will exploit cuttingedge biophysical tools exclusively developed in my Lab that combine super-resolution optical nanoscopy and single molecule dynamics in conjunction with simultaneous mechanical stimulation of living cells. Using this integrated approach, I will: First: dissect mechanical and biochemical coupling of membrane mechanosensing at the nanoscale. Second: visualise the coordinated recruitment of integrin-associated signalling proteins in response to force, i.e., mechanotransduction. Third: test how force-induced spatiotemporal membrane remodelling influences the migratory capacity of immune cells, i.e., mechanoresponse. NANO-MEMEC conveys a new fundamental concept to the field of mechanobiology: the roles of mechanical stimuli in the dynamic remodelling of membrane nanocompartments, modulating signal transduction and ultimately affecting cell response, opening new-fangled research avenues in the years to come.

2 212 063 €

Start date: 2018-12-01, End date: 2023-11-30

Understanding the causes of genome instability, a condition linked to cancer and cancer-prone genetic diseases, is a major question in Molecular Biology and Biomedicine. Probably the most important natural cause of genome instability is transcription, which is known to induce both mutation and recombination from bacteria to human cells. Different studies suggest that transcription-associated recombination (TAR) is in large part due to collisions between transcription and replication, but increasing evidence indicate that R-loops, formed by a DNA-RNA hybrid and a displaced single-stranded DNA, may be a major determinant of genome instability. This is of particular relevance, provided our recent observation that tumor suppressor BRCA2 gene is involved in R-loop prevention/resolution and that, therefore, R-loops may represent a major potential source of tumorigenesis. The goal of this project is to understand the mechanisms of R-loop dynamics by identifying the functions and elements acting in cis and trans, that is, the DNA sequences and genes controlling R-loop formation and removal. The project will be based on a multidisciplinary approach using Saccharomyces cerevisiae and human cell lines. We plan: a) to identify the proteins and mechanism that actively works in the formation and prevention of intermediates responsible for R-loop-mediated TAR; b) to define the histone residues linked to R-loop formation and its role in chromatin dynamics, and c) to establish how the different trans and cis elements control genome-wide R-loop–mediated genome instability whether or not in association with replication fork impairment, double-strand break accumulation, chromatin structure and mRNP biogenesis and export. The functional relevance of selected conserved genes will be validated in Caenorhabditis elegans as a model organism. The long-term objective of the proposal is to decipher the mechanisms by which R-loops modulate chromatin dynamics and genome instability.

2 312 500 €

Start date: 2015-12-01, End date: 2020-11-30

TRANSGANG aims to develop a renewed model for the analysis of transnational youth gangs in the global age, in dialogue with two classics of urban ethnography, published nearly a century ago: The Gang, by F.M. Thrasher (1926) and The Polish Peasant in Europe and America, by W. I. Thomas and F. Znaniecki (1918-1920). To do this, the project will start by a systematic review of the historical literature on youth gangs, which will try to overcome the north-american-centrism, dominant in contemporary criminology. The central phase of the research will focus on a multisited and multilevel ethnography that will explore experiences in which gangs have acted as agents of mediation, as well as the barriers that have blocked these attempts. The project will compare street youth organizations from two transnational communities -Latinos and Arabs-, both in their homelands and in their new European neigbourhoods. Starting with three case studies of “good practices” in Barcelona, Medellin and Casablanca, which will be studied in depth, contrasts with other cases in which other policies have been implemented will be established: Madrid, Marseille and Milan in southern Europe; Oran Tunis and Cairo in north Africa; Chicago, Santiago de Cuba and San Salvador in the Americas. Using an experimental approach based on the “extended case method”, it will have as its theme the making of a film that collects the experience of members or former members of gangs who have participated in mediation experiences. The ultimate goal is to develop a renewed transnational, inter-generational, intergeneric and transmedia approach to Twenty-First-century gangs, very different from the local, coeval, male and face-to-face model used for understanding gangs in the Twentieth century. Although the focus of the project is theoretical, its purpose is applied: to deduce more effective ways of intervention to prevent the hegemony of the criminal gang model that appears as dominant in the neoliberal era.

2 343 249 €

Start date: 2018-01-01, End date: 2022-12-31