Project acronym BRIDGES
Project Bridging Non-Equilibrium Problems: From the Fourier Law to Gene Expression
Researcher (PI) Jean-Pierre Eckmann
Host Institution (HI) UNIVERSITE DE GENEVE
Call Details Advanced Grant (AdG), PE1, ERC-2011-ADG_20110209
Summary My goal is to study several important open mathematical problems in non-equilibrium (NEQ) systems and to build a bridge between these problems and NEQ aspects of soft sciences, in particular biological questions. Traffic on this bridge is going to be two-way, the mathematics carrying a long history as a language of science towards the soft sciences, and the soft sciences fruitfully asking new questions and building new paradigms for mathematical research.
Out-of-equilibrium systems pose several fascinating problems: The Fourier law which says that resistance of a wire is proportional to its length is still presenting hard problems for research, and even the existence and the convergence to a NEQ steady state are continuously posing new puzzles, as do questions of smoothness and correlations of such states. These will be addressed with stochastic differential equations, and with particlescatterer systems, both canonical and grand-canonical. The latter are extensions of the well-known Lorentz gas and the study of hyperbolic billiards.
Another field where NEQ plays an important role is the study of glassy systems. They were studied with molecular dynamics (MD) but I have used a topological variant, which mimics astonishingly well what happens in MD simulations. The aim is to extend this to 3 dimensions, where new problems appear.
Finally, I will apply the NEQ studies to biological systems: How a system copes with the varying environment,adapting in this way to a novel type of NEQ. I will study networks of communication among neurons,which are like random graphs with the additional property of being embedded, and the arrangement of genes on chromosomes in such a way as to optimize the adaptation to the different cell types which must be produced using the same genetic information.
I will answer such questions with students and collaborators, who will specialize in the subprojects but will interact with my help across the common bridge.
Summary
My goal is to study several important open mathematical problems in non-equilibrium (NEQ) systems and to build a bridge between these problems and NEQ aspects of soft sciences, in particular biological questions. Traffic on this bridge is going to be two-way, the mathematics carrying a long history as a language of science towards the soft sciences, and the soft sciences fruitfully asking new questions and building new paradigms for mathematical research.
Out-of-equilibrium systems pose several fascinating problems: The Fourier law which says that resistance of a wire is proportional to its length is still presenting hard problems for research, and even the existence and the convergence to a NEQ steady state are continuously posing new puzzles, as do questions of smoothness and correlations of such states. These will be addressed with stochastic differential equations, and with particlescatterer systems, both canonical and grand-canonical. The latter are extensions of the well-known Lorentz gas and the study of hyperbolic billiards.
Another field where NEQ plays an important role is the study of glassy systems. They were studied with molecular dynamics (MD) but I have used a topological variant, which mimics astonishingly well what happens in MD simulations. The aim is to extend this to 3 dimensions, where new problems appear.
Finally, I will apply the NEQ studies to biological systems: How a system copes with the varying environment,adapting in this way to a novel type of NEQ. I will study networks of communication among neurons,which are like random graphs with the additional property of being embedded, and the arrangement of genes on chromosomes in such a way as to optimize the adaptation to the different cell types which must be produced using the same genetic information.
I will answer such questions with students and collaborators, who will specialize in the subprojects but will interact with my help across the common bridge.
Max ERC Funding
2 135 385 €
Duration
Start date: 2012-04-01, End date: 2017-07-31
Project acronym CausalStats
Project Statistics, Prediction and Causality for Large-Scale Data
Researcher (PI) Peter Lukas Bühlmann
Host Institution (HI) EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Call Details Advanced Grant (AdG), PE1, ERC-2017-ADG
Summary Understanding cause-effect relationships between variables is of great interest in many fields of science. However, causal inference from data is much more ambitious and difficult than inferring (undirected) measures of association such as correlations, partial correlations or multivariate regression coefficients, mainly because of fundamental identifiability
problems. A main objective of the proposal is to exploit advantages from large-scale heterogeneous data for causal inference where heterogeneity arises from different experimental conditions or different unknown sub-populations. A key idea is to consider invariance or stability across different experimental conditions of certain conditional probability distributions: the invariants correspond on the one hand to (properly defined) causal variables which are of main interest in causality; andon the other hand, they correspond to the features for constructing powerful predictions for new scenarios which are unobserved in the data (new probability distributions). This opens novel perspectives: causal inference
can be phrased as a prediction problem of a certain kind, and vice versa, new prediction methods which work well across different scenarios (unobserved in the data) should be based on or regularized towards causal variables. Fundamental identifiability limits will become weaker with increased degree of heterogeneity, as we expect in large-scale data. The topic is essentially unexplored, yet it opens new avenues for causal inference, structural equation and graphical modeling, and robust prediction based on large-scale complex data. We will develop mathematical theory, statistical methodology and efficient algorithms; and we will also work and collaborate on major application problems such as inferring causal effects (i.e., total intervention effects) from gene knock-out or RNA interference perturbation experiments, genome-wide association studies and novel prediction tasks in economics.
Summary
Understanding cause-effect relationships between variables is of great interest in many fields of science. However, causal inference from data is much more ambitious and difficult than inferring (undirected) measures of association such as correlations, partial correlations or multivariate regression coefficients, mainly because of fundamental identifiability
problems. A main objective of the proposal is to exploit advantages from large-scale heterogeneous data for causal inference where heterogeneity arises from different experimental conditions or different unknown sub-populations. A key idea is to consider invariance or stability across different experimental conditions of certain conditional probability distributions: the invariants correspond on the one hand to (properly defined) causal variables which are of main interest in causality; andon the other hand, they correspond to the features for constructing powerful predictions for new scenarios which are unobserved in the data (new probability distributions). This opens novel perspectives: causal inference
can be phrased as a prediction problem of a certain kind, and vice versa, new prediction methods which work well across different scenarios (unobserved in the data) should be based on or regularized towards causal variables. Fundamental identifiability limits will become weaker with increased degree of heterogeneity, as we expect in large-scale data. The topic is essentially unexplored, yet it opens new avenues for causal inference, structural equation and graphical modeling, and robust prediction based on large-scale complex data. We will develop mathematical theory, statistical methodology and efficient algorithms; and we will also work and collaborate on major application problems such as inferring causal effects (i.e., total intervention effects) from gene knock-out or RNA interference perturbation experiments, genome-wide association studies and novel prediction tasks in economics.
Max ERC Funding
2 184 375 €
Duration
Start date: 2018-10-01, End date: 2023-09-30
Project acronym CHANGE
Project New CHallenges for (adaptive) PDE solvers: the interplay of ANalysis and GEometry
Researcher (PI) Annalisa BUFFA
Host Institution (HI) ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Call Details Advanced Grant (AdG), PE1, ERC-2015-AdG
Summary The simulation of Partial Differential Equations (PDEs) is an indispensable tool for innovation in science and technology.
Computer-based simulation of PDEs approximates unknowns defined on a geometrical entity such as the computational domain with all of its properties. Mainly due to historical reasons, geometric design and numerical methods for PDEs have been developed independently, resulting in tools that rely on different representations of the same objects.
CHANGE aims at developing innovative mathematical tools for numerically solving PDEs and for geometric modeling and processing, the final goal being the definition of a common framework where geometrical entities and simulation are coherently integrated and where adaptive methods can be used to guarantee optimal use of computer resources, from the geometric description to the simulation.
We will concentrate on two classes of methods for the discretisation of PDEs that are having growing impact:
isogeometric methods and variational methods on polyhedral partitions. They are both extensions of standard finite elements enjoying exciting features, but both lack of an ad-hoc geometric modelling counterpart.
We will extend numerical methods to ensure robustness on the most general geometric models, and we will develop geometric tools to construct, manipulate and refine such models. Based on our tools, we will design an innovative adaptive framework, that jointly exploits multilevel representation of geometric entities and PDE unknowns.
Moreover, efficient algorithms call for efficient implementation: the issue of the optimisation of our algorithms on modern computer architecture will be addressed.
Our research (and the team involved in the project) will combine competencies in computer science, numerical analysis, high performance computing, and computational mechanics. Leveraging our innovative tools, we will also tackle challenging numerical problems deriving from bio-mechanical applications.
Summary
The simulation of Partial Differential Equations (PDEs) is an indispensable tool for innovation in science and technology.
Computer-based simulation of PDEs approximates unknowns defined on a geometrical entity such as the computational domain with all of its properties. Mainly due to historical reasons, geometric design and numerical methods for PDEs have been developed independently, resulting in tools that rely on different representations of the same objects.
CHANGE aims at developing innovative mathematical tools for numerically solving PDEs and for geometric modeling and processing, the final goal being the definition of a common framework where geometrical entities and simulation are coherently integrated and where adaptive methods can be used to guarantee optimal use of computer resources, from the geometric description to the simulation.
We will concentrate on two classes of methods for the discretisation of PDEs that are having growing impact:
isogeometric methods and variational methods on polyhedral partitions. They are both extensions of standard finite elements enjoying exciting features, but both lack of an ad-hoc geometric modelling counterpart.
We will extend numerical methods to ensure robustness on the most general geometric models, and we will develop geometric tools to construct, manipulate and refine such models. Based on our tools, we will design an innovative adaptive framework, that jointly exploits multilevel representation of geometric entities and PDE unknowns.
Moreover, efficient algorithms call for efficient implementation: the issue of the optimisation of our algorithms on modern computer architecture will be addressed.
Our research (and the team involved in the project) will combine competencies in computer science, numerical analysis, high performance computing, and computational mechanics. Leveraging our innovative tools, we will also tackle challenging numerical problems deriving from bio-mechanical applications.
Max ERC Funding
2 199 219 €
Duration
Start date: 2016-10-01, End date: 2021-09-30
Project acronym CHLIP
Project "Understanding Halogenated Lipids: Synthesis, Mode of Action, Structural Studies, and Applications"
Researcher (PI) Erick Moran Carreira
Host Institution (HI) EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Call Details Advanced Grant (AdG), PE5, ERC-2012-ADG_20120216
Summary "Among the various toxins isolated, the chlorosulfolipids are particularly intriguing because of their structural and stereochemical complexity. The mechanism of biological activity remains unknown. The lack of availability of the natural products has impaired more in-depth studies aimed at pharmacological, biological, and chemical characterization for proper evaluation of the risk for human health and their role in nature. The proposal takes as its basis this unusual class of natural products and delineates a multifaceted program of inquiry involving: (1) structural characterization of the most complex chlorosulfolipid isolated to date, (2) conformational studies in solution of chlorinated lipids, (3) synthesis and study of brominated lipid analogs, (4) development of analytical methods for detection of these toxins in the environment, (5) the discovery and development of reagents and catalysts for asymmetric chlorination of olefins, (6) examination of lipid conformation in constrained media, (7) examination of the mechanism of anchimeric assistance by chlorides, and (8) applications to drug discovery."
Summary
"Among the various toxins isolated, the chlorosulfolipids are particularly intriguing because of their structural and stereochemical complexity. The mechanism of biological activity remains unknown. The lack of availability of the natural products has impaired more in-depth studies aimed at pharmacological, biological, and chemical characterization for proper evaluation of the risk for human health and their role in nature. The proposal takes as its basis this unusual class of natural products and delineates a multifaceted program of inquiry involving: (1) structural characterization of the most complex chlorosulfolipid isolated to date, (2) conformational studies in solution of chlorinated lipids, (3) synthesis and study of brominated lipid analogs, (4) development of analytical methods for detection of these toxins in the environment, (5) the discovery and development of reagents and catalysts for asymmetric chlorination of olefins, (6) examination of lipid conformation in constrained media, (7) examination of the mechanism of anchimeric assistance by chlorides, and (8) applications to drug discovery."
Max ERC Funding
2 233 240 €
Duration
Start date: 2013-03-01, End date: 2018-02-28
Project acronym CLaQS
Project Correlations in Large Quantum Systems
Researcher (PI) Benjamin Schlein
Host Institution (HI) UNIVERSITAT ZURICH
Call Details Advanced Grant (AdG), PE1, ERC-2018-ADG
Summary This project is devoted to the mathematical analysis of important physical properties of many-body quantum systems. We will be interested in properties of the ground state and low-energy excitations but also of non-equilibrium dynamics. We are going to consider systems with different statistics and in different regimes. The questions we are going to address have a common aspect: correlations among particles play a crucial role. Our main goal consists in developing new tools that allow us to correctly describe many-body correlations and to understand their effects. The starting point of our proposal are ideas and techniques that have been introduced in a series of papers establishing the validity of Bogoliubov theory for Bose gases in the Gross-Pitaevskii regime, and in a recent preprint showing how (bosonic) Bogoliubov theory can also be used to study the correlation energy of Fermi gases. In this project, we plan to develop these techniques further and to apply them to new contexts. We believe they have the potential to approach some fundamental open problem in mathematical physics. Among our most ambitious objectives, we include the proof of the Lee-Huang-Yang formula for the energy of dilute Bose gases and of the corresponding Huang-Yang formula for dilute Fermi gases, as well as the derivation of the Gell-Mann--Brueckner expression for the correlation energy of a high density Fermi system. Furthermore, we propose to work on long-term projects (going beyond the duration of the grant) aiming at a rigorous justification of the quantum Boltzmann equation for fermions in the weak coupling limit and at a proof of Bose-Einstein condensation in the thermodynamic limit, two very challenging and important questions in the field.
Summary
This project is devoted to the mathematical analysis of important physical properties of many-body quantum systems. We will be interested in properties of the ground state and low-energy excitations but also of non-equilibrium dynamics. We are going to consider systems with different statistics and in different regimes. The questions we are going to address have a common aspect: correlations among particles play a crucial role. Our main goal consists in developing new tools that allow us to correctly describe many-body correlations and to understand their effects. The starting point of our proposal are ideas and techniques that have been introduced in a series of papers establishing the validity of Bogoliubov theory for Bose gases in the Gross-Pitaevskii regime, and in a recent preprint showing how (bosonic) Bogoliubov theory can also be used to study the correlation energy of Fermi gases. In this project, we plan to develop these techniques further and to apply them to new contexts. We believe they have the potential to approach some fundamental open problem in mathematical physics. Among our most ambitious objectives, we include the proof of the Lee-Huang-Yang formula for the energy of dilute Bose gases and of the corresponding Huang-Yang formula for dilute Fermi gases, as well as the derivation of the Gell-Mann--Brueckner expression for the correlation energy of a high density Fermi system. Furthermore, we propose to work on long-term projects (going beyond the duration of the grant) aiming at a rigorous justification of the quantum Boltzmann equation for fermions in the weak coupling limit and at a proof of Bose-Einstein condensation in the thermodynamic limit, two very challenging and important questions in the field.
Max ERC Funding
1 876 050 €
Duration
Start date: 2019-09-01, End date: 2024-08-31
Project acronym COMPASP
Project Complex analysis and statistical physics
Researcher (PI) Stanislav Smirnov
Host Institution (HI) UNIVERSITE DE GENEVE
Call Details Advanced Grant (AdG), PE1, ERC-2013-ADG
Summary "The goal of this project is to achieve breakthroughs in a few fundamental questions in 2D statistical physics, using techniques from complex analysis, probability, dynamical systems, geometric measure theory and theoretical physics.
Over the last decade, we significantly expanded our understanding of 2D lattice models of statistical physics, their conformally invariant scaling limits and related random geometries. However, there seem to be serious obstacles, preventing further development and requiring novel ideas. We plan to attack those, in particular we intend to:
(A) Describe new scaling limits by Schramm’s SLE curves and their generalizations,
(B) Study discrete complex structures and use them to describe more 2D models,
(C) Describe the scaling limits of random planar graphs by the Liouville Quantum Gravity,
(D) Understand universality and lay framework for the Renormalization Group Formalism,
(E) Go beyond the current setup of spin models and SLEs.
These problems are known to be very difficult, but fundamental questions, which have the potential to lead to significant breakthroughs in our understanding of phase transitions, allowing for further progresses. In resolving them, we plan to exploit interactions of different subjects, and recent advances are encouraging."
Summary
"The goal of this project is to achieve breakthroughs in a few fundamental questions in 2D statistical physics, using techniques from complex analysis, probability, dynamical systems, geometric measure theory and theoretical physics.
Over the last decade, we significantly expanded our understanding of 2D lattice models of statistical physics, their conformally invariant scaling limits and related random geometries. However, there seem to be serious obstacles, preventing further development and requiring novel ideas. We plan to attack those, in particular we intend to:
(A) Describe new scaling limits by Schramm’s SLE curves and their generalizations,
(B) Study discrete complex structures and use them to describe more 2D models,
(C) Describe the scaling limits of random planar graphs by the Liouville Quantum Gravity,
(D) Understand universality and lay framework for the Renormalization Group Formalism,
(E) Go beyond the current setup of spin models and SLEs.
These problems are known to be very difficult, but fundamental questions, which have the potential to lead to significant breakthroughs in our understanding of phase transitions, allowing for further progresses. In resolving them, we plan to exploit interactions of different subjects, and recent advances are encouraging."
Max ERC Funding
1 995 900 €
Duration
Start date: 2014-01-01, End date: 2018-12-31
Project acronym CONFRA
Project Conformal fractals in analysis, dynamics, physics
Researcher (PI) Stanislav Smirnov
Host Institution (HI) UNIVERSITE DE GENEVE
Call Details Advanced Grant (AdG), PE1, ERC-2008-AdG
Summary The goal of this project is to study conformally invariant fractal structures from the perspectives of analysis, dynamics, probability, geometry and physics, emphasizing interrelations of these fields. In the last two decades such structures emerged in several areas: continuum scaling limits of 2D critical models in statistical physics (percolation, Ising model); extremal configurations for various problems in complex analysis (multifractal harmonic measures, coefficient growth of univalent maps, Brennan's conjecture); chaotic sets for complex dynamical systems (Julia sets, Kleinian groups). Capitalizing on recent successes, I plan to continue my work in these areas, exploiting their interactions and connections to physics. I intend to achieve at least some of the following goals: * To establish that several critical lattice models have conformally invariant scaling limits, by building upon results on percolation and Ising models and finding discrete holomorphic observables. * To study geometric properties of arising fractal curves and random fields by connecting them to Schramm's SLE curves and Gaussian Free Fields. * To investigate massive scaling limits by describing them geometrically with generalizations of SLEs. * To lay mathematical framework behind relevant physical notions, such as Coulomb Gas (by relating height functions to GFFs) and Quantum Gravity (by identifying limits of random planar graphs with Liouville QGs). * To improve known bounds in several old questions in complex analysis by studying multifractal spectra of harmonic measures. * To estimate extremal behavior of such spectra by using holomorphic motions of (quasi) conformal maps and thermodynamic formalism. * To understand nature of extremal multifractals for harmonic measure by studying random and dynamical fractals. The topics involved range from century old to very young ones. Recently connections between them started to emerge, opening exciting possibilities for new developments in some long standing open problems.
Summary
The goal of this project is to study conformally invariant fractal structures from the perspectives of analysis, dynamics, probability, geometry and physics, emphasizing interrelations of these fields. In the last two decades such structures emerged in several areas: continuum scaling limits of 2D critical models in statistical physics (percolation, Ising model); extremal configurations for various problems in complex analysis (multifractal harmonic measures, coefficient growth of univalent maps, Brennan's conjecture); chaotic sets for complex dynamical systems (Julia sets, Kleinian groups). Capitalizing on recent successes, I plan to continue my work in these areas, exploiting their interactions and connections to physics. I intend to achieve at least some of the following goals: * To establish that several critical lattice models have conformally invariant scaling limits, by building upon results on percolation and Ising models and finding discrete holomorphic observables. * To study geometric properties of arising fractal curves and random fields by connecting them to Schramm's SLE curves and Gaussian Free Fields. * To investigate massive scaling limits by describing them geometrically with generalizations of SLEs. * To lay mathematical framework behind relevant physical notions, such as Coulomb Gas (by relating height functions to GFFs) and Quantum Gravity (by identifying limits of random planar graphs with Liouville QGs). * To improve known bounds in several old questions in complex analysis by studying multifractal spectra of harmonic measures. * To estimate extremal behavior of such spectra by using holomorphic motions of (quasi) conformal maps and thermodynamic formalism. * To understand nature of extremal multifractals for harmonic measure by studying random and dynamical fractals. The topics involved range from century old to very young ones. Recently connections between them started to emerge, opening exciting possibilities for new developments in some long standing open problems.
Max ERC Funding
1 278 000 €
Duration
Start date: 2009-01-01, End date: 2013-12-31
Project acronym DrEAM
Project Directed Evolution of Artificial Metalloenzymes for In Vivo Applications
Researcher (PI) Thomas WARD
Host Institution (HI) UNIVERSITAT BASEL
Call Details Advanced Grant (AdG), PE5, ERC-2015-AdG
Summary In the past decade, artificial metalloenzymes (AMs) have emerged as an attractive alternative to the more traditional enzymes and homogeneous catalysts. Such hybrid catalysts result from the incorporation of an abiotic metal cofactor within a macromolecule (protein or oligonucleotide). Artificial metalloenzymes combine attractive features of both homogeneous catalysts and enzymes, including the possibility to genetically optimize the catalytic performance of new-to-nature organometallic reactions. Can artificial metalloenzymes become as catalytically efficient as naturally-evolved metalloenzymes, even in complex biological mixtures? Herein, we outline our efforts to address this challenge by localizing and evolving AMs within the periplasm of Escherichia coli.
To achieve this objective, we will exploit AMs based on the biotin-streptavidin technology. Four subprojects have been tailored to address the challenges: i) knock-out deleterious components present in the periplasm; ii) improve the cofactor uptake through the outer-membrane; iii) engineer streptavidin to boost the AM’s performance; and iv) rely both on screening and selection strategies to evolve AMs in vivo. Relying on auxotrophs, we will demonstrate the potential of AMs to complement metabolic pathways. Only E. coli auxotrophs containing an evolved AM capable of producing the vital aminoacid-precursor will survive the stringent selection pressure. We have identified several selectable aminoacid precursors which can be produced by metathesis (indole, precursor of tryptophan), enone reduction (keto valine, precursor of valine) and allylic substitution (prephenate, precursor of tyrosine and phenylalanine). In a Darwinian evolution spirit, we anticipate that applying selection pressure will allow to evolve AMs to unprecedented catalytic performance.
The main deliverable of the DrEAM is an engineered and evolvable E. coli strain capable of performing in vivo reaction cascades combining AMs and natural enzymes.
Summary
In the past decade, artificial metalloenzymes (AMs) have emerged as an attractive alternative to the more traditional enzymes and homogeneous catalysts. Such hybrid catalysts result from the incorporation of an abiotic metal cofactor within a macromolecule (protein or oligonucleotide). Artificial metalloenzymes combine attractive features of both homogeneous catalysts and enzymes, including the possibility to genetically optimize the catalytic performance of new-to-nature organometallic reactions. Can artificial metalloenzymes become as catalytically efficient as naturally-evolved metalloenzymes, even in complex biological mixtures? Herein, we outline our efforts to address this challenge by localizing and evolving AMs within the periplasm of Escherichia coli.
To achieve this objective, we will exploit AMs based on the biotin-streptavidin technology. Four subprojects have been tailored to address the challenges: i) knock-out deleterious components present in the periplasm; ii) improve the cofactor uptake through the outer-membrane; iii) engineer streptavidin to boost the AM’s performance; and iv) rely both on screening and selection strategies to evolve AMs in vivo. Relying on auxotrophs, we will demonstrate the potential of AMs to complement metabolic pathways. Only E. coli auxotrophs containing an evolved AM capable of producing the vital aminoacid-precursor will survive the stringent selection pressure. We have identified several selectable aminoacid precursors which can be produced by metathesis (indole, precursor of tryptophan), enone reduction (keto valine, precursor of valine) and allylic substitution (prephenate, precursor of tyrosine and phenylalanine). In a Darwinian evolution spirit, we anticipate that applying selection pressure will allow to evolve AMs to unprecedented catalytic performance.
The main deliverable of the DrEAM is an engineered and evolvable E. coli strain capable of performing in vivo reaction cascades combining AMs and natural enzymes.
Max ERC Funding
2 490 700 €
Duration
Start date: 2016-10-01, End date: 2021-09-30
Project acronym EPCABO
Project Engineered Protein Capsids as Artificial Bacterial Organelles
Researcher (PI) Donald Michael Hilvert
Host Institution (HI) EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Call Details Advanced Grant (AdG), PE5, ERC-2012-ADG_20120216
Summary Many proteins self-assemble into regular, shell-like, polyhedral structures. Protein capsids are useful, both in nature and in the laboratory, as molecular containers for diverse cargo molecules, including proteins, nucleic acids, metal nanoparticles, quantum dots, and low molecular weight drugs. They can consequently serve as delivery vehicles, bioimaging agents, reaction vessels, and templates for the controlled synthesis of novel materials. Here, we will apply our experience with protein design and laboratory evolution to extend the properties of protein containers to create practical, non-viral encapsulation systems for applications in the test tube and in living cells. Specifically, we will adapt the icosohedral cage structures formed by Aquifex aeolicus lumazine synthase (AaLS) to engineer increasingly sophisticated supramolecular complexes for use as delivery vehicles, nanoreactors and, ultimately, as bacterial organelles. Our principal aims are to: (a) tailor AaLS capsids for selective encapsulation of a broad range of macromolecular guests; (b) develop AaLS capsids as delivery vehicles for medical and imaging applications; (c) design simplified, functional mimics of carbon-fixing carboxysomes; (d) evolve redox active organelles for metabolizing aliphatic alcohols; and (e) engineer artificial organelles for the detoxification of polychlorinated phenols. We anticipate that these experiments will lead to a deeper understanding of the principles underlying the construction, function and evolution of natural protein microcompartments. At the same time, they will establish powerful strategies for creating tailored assemblies for practical applications in delivery and catalysis.
Summary
Many proteins self-assemble into regular, shell-like, polyhedral structures. Protein capsids are useful, both in nature and in the laboratory, as molecular containers for diverse cargo molecules, including proteins, nucleic acids, metal nanoparticles, quantum dots, and low molecular weight drugs. They can consequently serve as delivery vehicles, bioimaging agents, reaction vessels, and templates for the controlled synthesis of novel materials. Here, we will apply our experience with protein design and laboratory evolution to extend the properties of protein containers to create practical, non-viral encapsulation systems for applications in the test tube and in living cells. Specifically, we will adapt the icosohedral cage structures formed by Aquifex aeolicus lumazine synthase (AaLS) to engineer increasingly sophisticated supramolecular complexes for use as delivery vehicles, nanoreactors and, ultimately, as bacterial organelles. Our principal aims are to: (a) tailor AaLS capsids for selective encapsulation of a broad range of macromolecular guests; (b) develop AaLS capsids as delivery vehicles for medical and imaging applications; (c) design simplified, functional mimics of carbon-fixing carboxysomes; (d) evolve redox active organelles for metabolizing aliphatic alcohols; and (e) engineer artificial organelles for the detoxification of polychlorinated phenols. We anticipate that these experiments will lead to a deeper understanding of the principles underlying the construction, function and evolution of natural protein microcompartments. At the same time, they will establish powerful strategies for creating tailored assemblies for practical applications in delivery and catalysis.
Max ERC Funding
1 889 200 €
Duration
Start date: 2013-03-01, End date: 2018-12-31
Project acronym EQUIARITH
Project Equidistribution in number theory
Researcher (PI) Philippe Michel
Host Institution (HI) ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Call Details Advanced Grant (AdG), PE1, ERC-2008-AdG
Summary The purpose of this proposal is to investigate from various perspectives some equidistribution problems associated with homogeneous spaces of arithmetic type: a typical problem (basically solved) is the distribution of the set of representations of a large integer by an integral quadratic form. Another harder problem is the study of the distribution of special points on Shimura varieties. In a different direction (linked with quantum chaos), the study of the concentration of Laplacian (Maass) eigenforms or of sections of holomorphic bundles is related to similar problems. Given X such a space and G>L the underlying algebraic group and its corresponding lattice L, the above questions boil down to studying the distribution of H-orbits x.H (or more generally H-invariant measures)on the quotient L\G for some subgroups H. This question may be studied different methods: Harmonic Analysis (HA): given a function f on L\G one studies the period integral of f along x.H. This may be done by automorphic methods. In favorable circumstances, the above periods are related to L-functions which one may hope to treat by methods from analytic number theory (the subconvexity problem). Ergodic Theory (ET): one studies the properties of weak*-limits of the measures supported by x.H using rigidity techniques: depending on the nature of H, one might use either rigidity of unipotent actions or the more recent rigidity results for torus actions in rank >1. In fact, HA and ET are intertwined and complementary : the use of ET in this context require a substantial input from number theory and HA, while ET lead to a soft understanding of several features of HA. In addition, the Langlands correspondence principle make it possible to pass from one group G to another. Based on earlier experience, our goal is to develop these interactions systematically and to develop new approaches to outstanding arithmetic problems :eg. the subconvexity problem or the Andre/Oort conjecture.
Summary
The purpose of this proposal is to investigate from various perspectives some equidistribution problems associated with homogeneous spaces of arithmetic type: a typical problem (basically solved) is the distribution of the set of representations of a large integer by an integral quadratic form. Another harder problem is the study of the distribution of special points on Shimura varieties. In a different direction (linked with quantum chaos), the study of the concentration of Laplacian (Maass) eigenforms or of sections of holomorphic bundles is related to similar problems. Given X such a space and G>L the underlying algebraic group and its corresponding lattice L, the above questions boil down to studying the distribution of H-orbits x.H (or more generally H-invariant measures)on the quotient L\G for some subgroups H. This question may be studied different methods: Harmonic Analysis (HA): given a function f on L\G one studies the period integral of f along x.H. This may be done by automorphic methods. In favorable circumstances, the above periods are related to L-functions which one may hope to treat by methods from analytic number theory (the subconvexity problem). Ergodic Theory (ET): one studies the properties of weak*-limits of the measures supported by x.H using rigidity techniques: depending on the nature of H, one might use either rigidity of unipotent actions or the more recent rigidity results for torus actions in rank >1. In fact, HA and ET are intertwined and complementary : the use of ET in this context require a substantial input from number theory and HA, while ET lead to a soft understanding of several features of HA. In addition, the Langlands correspondence principle make it possible to pass from one group G to another. Based on earlier experience, our goal is to develop these interactions systematically and to develop new approaches to outstanding arithmetic problems :eg. the subconvexity problem or the Andre/Oort conjecture.
Max ERC Funding
866 000 €
Duration
Start date: 2008-12-01, End date: 2013-11-30
Project acronym ESEI
Project Engineering Social and Economic Institutions
Researcher (PI) Jacob Goeree
Host Institution (HI) UNIVERSITAT ZURICH
Call Details Advanced Grant (AdG), SH1, ERC-2009-AdG
Summary The advent of the Internet and the increased power of modern day computing have dramatically changed the economic landscape. Billions of dollars worth of goods are being auctioned among geographically dispersed buyers; online brokerages are used to find jobs, trade stocks, make travel arrangements, etc. The architecture of these online (trading) platforms is typically rooted in their pre-Internet counterparts, and advances in the theory of market design combined with increased computing capabilities prompt a careful re-evaluation. This proposal concerns the creation of novel, more flexible institutions using an approach that combines theory, laboratory experiments, and practical policy. The first project enhances our understanding of newly designed package auctions by developing equilibrium models of competitive bidding and measuring the efficacy of alternative formats in controlled experiments. The next project studies novel market forms that allow for all-or-nothing trades to alleviate inefficiencies and enhance dynamic stability when complementarities exist. The third project concerns the design of market regulation and procurement contests to create better incentives for research and development. The fourth project addresses information aggregation properties of alternative voting institutions, suggesting improvements for referenda and jury/committee voting. The Internet has also dramatically altered the nature of social interactions. Emerging institutions such as online social networking tools, rating systems, and web-community Q&A services reduce social distances and catalyze opportunities for social learning. The final project focuses on social learning in a variety of settings and on the impact of social networks on behavior. Combined these projects generate insights that apply to a broad array of social and economic environments and that will guide practitioners to the use of better designed institutions.
Summary
The advent of the Internet and the increased power of modern day computing have dramatically changed the economic landscape. Billions of dollars worth of goods are being auctioned among geographically dispersed buyers; online brokerages are used to find jobs, trade stocks, make travel arrangements, etc. The architecture of these online (trading) platforms is typically rooted in their pre-Internet counterparts, and advances in the theory of market design combined with increased computing capabilities prompt a careful re-evaluation. This proposal concerns the creation of novel, more flexible institutions using an approach that combines theory, laboratory experiments, and practical policy. The first project enhances our understanding of newly designed package auctions by developing equilibrium models of competitive bidding and measuring the efficacy of alternative formats in controlled experiments. The next project studies novel market forms that allow for all-or-nothing trades to alleviate inefficiencies and enhance dynamic stability when complementarities exist. The third project concerns the design of market regulation and procurement contests to create better incentives for research and development. The fourth project addresses information aggregation properties of alternative voting institutions, suggesting improvements for referenda and jury/committee voting. The Internet has also dramatically altered the nature of social interactions. Emerging institutions such as online social networking tools, rating systems, and web-community Q&A services reduce social distances and catalyze opportunities for social learning. The final project focuses on social learning in a variety of settings and on the impact of social networks on behavior. Combined these projects generate insights that apply to a broad array of social and economic environments and that will guide practitioners to the use of better designed institutions.
Max ERC Funding
1 797 525 €
Duration
Start date: 2010-01-01, End date: 2015-12-31
Project acronym FEP
Project Foundations of Economic Preferences
Researcher (PI) Ernst Fehr
Host Institution (HI) UNIVERSITAT ZURICH
Call Details Advanced Grant (AdG), SH1, ERC-2011-ADG_20110406
Summary Preferences are a representation of individuals’ behavioral goals. Assumptions about individual preferences are a decisive component of almost all economic models. In fact, any social science that aims at explaining both individual behaviors and aggregate outcomes in terms of individuals’ goals and constraints has to make assumptions about preferences. Knowledge about preferences is thus key for the ability to predict the behavior of individuals and groups, and for assessing the welfare consequences of different policies. There are, however, still large empirical gaps in our knowledge about preferences. Extremely little is known about the social, economic and biological factors that causally shape them. There is also limited knowledge about how preferences are distributed in society, how they relate to demographic and socio-economic factors, how time, risk and social preferences are interrelated, and the extent to which preferences are stable across time and strategic situations. Therefore, we propose to study these foundational questions by applying economic and neuroeconomic tools that enable us to measure structural preference parameters and the social and biological forces that shape them. In particular, we will study the four following topics. (1) The distribution and stability of time, risk and social preference parameters based on nationally representative behavioral experiments. (2) The relationship between time, risk and social preferences. (3) The causal impact of the social environment on preferences. (4) The neural and genetic determinants of preferences. The proposed research program promises to yield important insights into the causal determinants, the structure and the relationships between time, risk and social preferences. This will inform and constrain theoretical models and policy conclusions based on such models.
Summary
Preferences are a representation of individuals’ behavioral goals. Assumptions about individual preferences are a decisive component of almost all economic models. In fact, any social science that aims at explaining both individual behaviors and aggregate outcomes in terms of individuals’ goals and constraints has to make assumptions about preferences. Knowledge about preferences is thus key for the ability to predict the behavior of individuals and groups, and for assessing the welfare consequences of different policies. There are, however, still large empirical gaps in our knowledge about preferences. Extremely little is known about the social, economic and biological factors that causally shape them. There is also limited knowledge about how preferences are distributed in society, how they relate to demographic and socio-economic factors, how time, risk and social preferences are interrelated, and the extent to which preferences are stable across time and strategic situations. Therefore, we propose to study these foundational questions by applying economic and neuroeconomic tools that enable us to measure structural preference parameters and the social and biological forces that shape them. In particular, we will study the four following topics. (1) The distribution and stability of time, risk and social preference parameters based on nationally representative behavioral experiments. (2) The relationship between time, risk and social preferences. (3) The causal impact of the social environment on preferences. (4) The neural and genetic determinants of preferences. The proposed research program promises to yield important insights into the causal determinants, the structure and the relationships between time, risk and social preferences. This will inform and constrain theoretical models and policy conclusions based on such models.
Max ERC Funding
2 494 759 €
Duration
Start date: 2012-08-01, End date: 2018-07-31
Project acronym FIRM
Project Mathematical Methods for Financial Risk Management
Researcher (PI) Halil Mete Soner
Host Institution (HI) EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Call Details Advanced Grant (AdG), PE1, ERC-2008-AdG
Summary Since the pioneering works of Black & Scholes, Merton and Markowitch, sophisticated quantitative methods are being used to introduce more complex financial products each year. However, this exciting increase in the complexity forces the industry to engage in proper risk management practices. The recent financial crisis emanating from risky loan practices is a prime example of this acute need. This proposal focuses exactly on this general problem. We will develop mathematical techniques to measure and assess the financial risk of new instruments. In the theoretical direction, we will expand the scope of recent studies on risk measures of Artzner et-al., and the stochastic representation formulae proved by the principal investigator and his collaborators. The core research team consists of mathematicians and the finance faculty. The newly created state-of-the-art finance laboratory at the host institution will have direct access to financial data. Moreover, executive education that is performed in this unit enables the research group to have close contacts with high level executives of the financial industry. The theoretical side of the project focuses on nonlinear partial differential equations (PDE), backward stochastic differential equations (BSDE) and dynamic risk measures. Already a deep connection between BSDEs and dynamic risk measures is developed by Peng, Delbaen and collaborators. Also, the principal investigator and his collaborators developed connections to PDEs. In this project, we further investigate these connections. Chief goals of this project are theoretical results and computational techniques in the general areas of BSDEs, fully nonlinear PDEs, and the development of risk management practices that are acceptable by the industry. The composition of the research team and our expertise in quantitative methods, well position us to effectively formulate and study theoretical problems with financial impact.
Summary
Since the pioneering works of Black & Scholes, Merton and Markowitch, sophisticated quantitative methods are being used to introduce more complex financial products each year. However, this exciting increase in the complexity forces the industry to engage in proper risk management practices. The recent financial crisis emanating from risky loan practices is a prime example of this acute need. This proposal focuses exactly on this general problem. We will develop mathematical techniques to measure and assess the financial risk of new instruments. In the theoretical direction, we will expand the scope of recent studies on risk measures of Artzner et-al., and the stochastic representation formulae proved by the principal investigator and his collaborators. The core research team consists of mathematicians and the finance faculty. The newly created state-of-the-art finance laboratory at the host institution will have direct access to financial data. Moreover, executive education that is performed in this unit enables the research group to have close contacts with high level executives of the financial industry. The theoretical side of the project focuses on nonlinear partial differential equations (PDE), backward stochastic differential equations (BSDE) and dynamic risk measures. Already a deep connection between BSDEs and dynamic risk measures is developed by Peng, Delbaen and collaborators. Also, the principal investigator and his collaborators developed connections to PDEs. In this project, we further investigate these connections. Chief goals of this project are theoretical results and computational techniques in the general areas of BSDEs, fully nonlinear PDEs, and the development of risk management practices that are acceptable by the industry. The composition of the research team and our expertise in quantitative methods, well position us to effectively formulate and study theoretical problems with financial impact.
Max ERC Funding
880 560 €
Duration
Start date: 2008-12-01, End date: 2013-11-30
Project acronym FUBSSY
Project Functional Biosupramolecular Systems: Photosystems and Sensors
Researcher (PI) Stefan Georg Jean-Petit-Matile
Host Institution (HI) UNIVERSITE DE GENEVE
Call Details Advanced Grant (AdG), PE5, ERC-2010-AdG_20100224
Summary The general objective of this proposal is to discover access to ordered, soft and smart matter for use in materials sciences (e.g. molecular optoelectronics, organic solar cells), biology, medicine and chemistry.
Specific aim 1 focuses on two complementary approaches (zipper assembly; self-organizing surface-initiated polymerization, SOSIP) to build artificial photosystems on solid surfaces, including supramolecular n/p-heterojunctions with oriented multicolor antiparallel redox gradients (“OMARG-SHJs”).
Specific aim 2 is to create sensing systems in lipid bilayers that operate by pattern recognition with polyion/counterion complexes, and to apply the lessons learned to several interconnected topics (diagnostics, fluorescent membrane/nitrate probes, cellular uptake, organocatalysis with anion-À interactions).
To address these challenges, crossfertilization at the interface of synthetic, supramolecular, biological and materials chemistry will be essential. To produce the broad horizons needed for crossfertilization, projects on different topics are run in parallel. The proposed approach builds in general on the distinguishing expertise of the (organic) chemist to create new matter, i.e., multistep organic synthesis. To identify significant, that is responsive or “smart” systems, the invention of functional feedback loops will be emphasized.
Success with aim 1 will provide general solutions to key problems (OMARG-SHJs, SOSIP) and thus lead to broad applications (including high-efficiency organic photovoltaics and dye-sensitized solar cells). Success with aim 2 will afford synthetic sensing systems that operate, closer than ever, like the membrane-based mammalian olfactory and gustatory systems and open new approaches to crossdisciplinary topics as specified above.
Summary
The general objective of this proposal is to discover access to ordered, soft and smart matter for use in materials sciences (e.g. molecular optoelectronics, organic solar cells), biology, medicine and chemistry.
Specific aim 1 focuses on two complementary approaches (zipper assembly; self-organizing surface-initiated polymerization, SOSIP) to build artificial photosystems on solid surfaces, including supramolecular n/p-heterojunctions with oriented multicolor antiparallel redox gradients (“OMARG-SHJs”).
Specific aim 2 is to create sensing systems in lipid bilayers that operate by pattern recognition with polyion/counterion complexes, and to apply the lessons learned to several interconnected topics (diagnostics, fluorescent membrane/nitrate probes, cellular uptake, organocatalysis with anion-À interactions).
To address these challenges, crossfertilization at the interface of synthetic, supramolecular, biological and materials chemistry will be essential. To produce the broad horizons needed for crossfertilization, projects on different topics are run in parallel. The proposed approach builds in general on the distinguishing expertise of the (organic) chemist to create new matter, i.e., multistep organic synthesis. To identify significant, that is responsive or “smart” systems, the invention of functional feedback loops will be emphasized.
Success with aim 1 will provide general solutions to key problems (OMARG-SHJs, SOSIP) and thus lead to broad applications (including high-efficiency organic photovoltaics and dye-sensitized solar cells). Success with aim 2 will afford synthetic sensing systems that operate, closer than ever, like the membrane-based mammalian olfactory and gustatory systems and open new approaches to crossdisciplinary topics as specified above.
Max ERC Funding
1 906 200 €
Duration
Start date: 2011-01-01, End date: 2015-12-31
Project acronym IPCDP
Project Institutions, Policy and Culture in the Development Process
Researcher (PI) Fabrizio Zilibotti
Host Institution (HI) UNIVERSITAT ZURICH
Call Details Advanced Grant (AdG), SH1, ERC-2008-AdG
Summary This project aims at developing theoretical and empirical research on the structural transformation that accompanies economic development and on the determinants of its success or failure. This transformation involves changes in policies, institutions, and even preferences and social hierarchies. The project consists of four subprojects. Since China represents the most spectacular ongoing episode of economic transition, four of them focus on the Chinese experience, while the remaining ones address general issues in growth and development. The first subproject analyses some puzzling features of China's recent growth experience, such as the coexistence of high growth with increasing capital export, and the falling labour share, with the aid of a theory which emphasises the efficiency gains associated with the reallocation between firms of different productivity. Since changes in income distribution are an important element, and a concern, of the Chinese transition, the three following subprojects focus, respectively, on the crisis of the system of old age insurance, the effects of the rise of the middle class, and the introduction of special economic zones in the 1980s. Two subprojects study different aspects of competition policy in development. The first one focuses on intellectual property right protection, emphasising the link between innovation, technology adoption and human capital accumulation. The second one studies the coordinating role of industrial policy and how its scope changes with development. The last two subprojects focus on culture. The diffusion of preferences and values that foster cooperation rather than conflict is no less important than incentives for technology adoption. Likewise, the rise of an "entrepreneurial spirit" is an engine of growth in the development transition. We plan to study the emergence and cultural transmission of preferences that are conducive to economic growth, and how they interact with the process of structural change.
Summary
This project aims at developing theoretical and empirical research on the structural transformation that accompanies economic development and on the determinants of its success or failure. This transformation involves changes in policies, institutions, and even preferences and social hierarchies. The project consists of four subprojects. Since China represents the most spectacular ongoing episode of economic transition, four of them focus on the Chinese experience, while the remaining ones address general issues in growth and development. The first subproject analyses some puzzling features of China's recent growth experience, such as the coexistence of high growth with increasing capital export, and the falling labour share, with the aid of a theory which emphasises the efficiency gains associated with the reallocation between firms of different productivity. Since changes in income distribution are an important element, and a concern, of the Chinese transition, the three following subprojects focus, respectively, on the crisis of the system of old age insurance, the effects of the rise of the middle class, and the introduction of special economic zones in the 1980s. Two subprojects study different aspects of competition policy in development. The first one focuses on intellectual property right protection, emphasising the link between innovation, technology adoption and human capital accumulation. The second one studies the coordinating role of industrial policy and how its scope changes with development. The last two subprojects focus on culture. The diffusion of preferences and values that foster cooperation rather than conflict is no less important than incentives for technology adoption. Likewise, the rise of an "entrepreneurial spirit" is an engine of growth in the development transition. We plan to study the emergence and cultural transmission of preferences that are conducive to economic growth, and how they interact with the process of structural change.
Max ERC Funding
1 599 996 €
Duration
Start date: 2009-01-01, End date: 2014-06-30
Project acronym lending
Project Drivers of Growth in Bank Lending and Financial Crises
Researcher (PI) Steven ONGENA
Host Institution (HI) UNIVERSITAT ZURICH
Call Details Advanced Grant (AdG), SH1, ERC-2016-ADG
Summary Banking crises are thought to be recurrent phenomena that generally come on the heels of strong credit growth. Their damaging real effects have generated a broad agreement among academics and policymakers that financial regulation needs to tighten and to obtain a macroprudential dimension that aims to lessen the negative externalities from the financial to the macro real sector.
Among the main ingredients that are often mentioned to have played a role in the explosive growth of credit in the run-up to the latest financial crisis are the financial innovations by financial institutions, in particular loan securitization, the boom in mortgage lending and prices of real estate, the lack of information about prospective borrowers, and the high leverage (and corresponding low capital ratios) of financial institutions.
Yet, despite the singling out of these ingredients by policymakers, decisive empirical evidence about their role and relevancy is lacking. However, given the magnitude and complexity of the global banking system and the lack of encompassing micro-level data, it is currently impossible to confidently study the impact of all ingredients jointly. This project therefore analyses pertinent settings where we can empirically identify the correspondence between the aforementioned individual ingredients and the credit granting by financial institutions.
The objective of the project is to advance identification and estimation of the impact of each respective factor on loan growth by combining the appropriate methodology with an exceptional set of micro-level datasets. When missing in the literature a theoretical framework will be provided. The project further aims to assess how potential combinations of these ingredients may have interacted in spurring credit growth. While the identification of the impact of each ingredient on credit growth is paramount, the individual setting of the studied datasets and employed methodologies will ensure maximum external validity.
Summary
Banking crises are thought to be recurrent phenomena that generally come on the heels of strong credit growth. Their damaging real effects have generated a broad agreement among academics and policymakers that financial regulation needs to tighten and to obtain a macroprudential dimension that aims to lessen the negative externalities from the financial to the macro real sector.
Among the main ingredients that are often mentioned to have played a role in the explosive growth of credit in the run-up to the latest financial crisis are the financial innovations by financial institutions, in particular loan securitization, the boom in mortgage lending and prices of real estate, the lack of information about prospective borrowers, and the high leverage (and corresponding low capital ratios) of financial institutions.
Yet, despite the singling out of these ingredients by policymakers, decisive empirical evidence about their role and relevancy is lacking. However, given the magnitude and complexity of the global banking system and the lack of encompassing micro-level data, it is currently impossible to confidently study the impact of all ingredients jointly. This project therefore analyses pertinent settings where we can empirically identify the correspondence between the aforementioned individual ingredients and the credit granting by financial institutions.
The objective of the project is to advance identification and estimation of the impact of each respective factor on loan growth by combining the appropriate methodology with an exceptional set of micro-level datasets. When missing in the literature a theoretical framework will be provided. The project further aims to assess how potential combinations of these ingredients may have interacted in spurring credit growth. While the identification of the impact of each ingredient on credit growth is paramount, the individual setting of the studied datasets and employed methodologies will ensure maximum external validity.
Max ERC Funding
2 103 440 €
Duration
Start date: 2017-09-01, End date: 2022-08-31
Project acronym LILO
Project Light-In, Light-Out: Chemistry for sustainable energy technologies
Researcher (PI) Edwin Charles Constable
Host Institution (HI) UNIVERSITAT BASEL
Call Details Advanced Grant (AdG), PE5, ERC-2010-AdG_20100224
Summary The project is concerned with a coordinated approach to the development of of novel chemical strategies for light harvesting by photovoltaic cells and light generation using light emitting electrochemical cells. Both technologies have proof of principle results from the PIs own laboratory and others world-wide. The bulk of efficient dye sensitized solar cells rely on transition metal complexes as the photoactive component as the majority of traditional organic dyes do not possess long term stability under the operating conditions of the devices. LECs based upon transition metal complexes have been shown to possess lifetimes sufficiently long and efficiencies sufficiently high to become a viable alternative technology to OLEDs in the near future. The disadvantages of state of the art devices for both technologies is that they are based upon second or third row transition metal complexes. Although these elements are expensive, the principle difficulties arise from their low abundance, which creates significant issues of sustainability if the technology is to be adopted. The aim of this project is three-fold. Firstly, to further optimise the individual technologies using conventional transition metal complexes, with increases in efficiency leading to lower metal requirements. Secondly, to explore the periodic table for metal-containing luminophores based on first row transition metals, with an emphasis upon copper and zinc containing species. The final aspect is related to the utilization of solar derived electrons for water splitting reactions, allowing the generation of hydrogen and/or reaction products of hydrogen with organic species. This latter aspect is related to the mid-term requirement for liquid fuels, regardless of the primary fuel sources utilized. The program will involve design and synthesis of new materials, device construction and evaluation (in-house and with existing academic and industrial partners) and iterative refinement of structures
Summary
The project is concerned with a coordinated approach to the development of of novel chemical strategies for light harvesting by photovoltaic cells and light generation using light emitting electrochemical cells. Both technologies have proof of principle results from the PIs own laboratory and others world-wide. The bulk of efficient dye sensitized solar cells rely on transition metal complexes as the photoactive component as the majority of traditional organic dyes do not possess long term stability under the operating conditions of the devices. LECs based upon transition metal complexes have been shown to possess lifetimes sufficiently long and efficiencies sufficiently high to become a viable alternative technology to OLEDs in the near future. The disadvantages of state of the art devices for both technologies is that they are based upon second or third row transition metal complexes. Although these elements are expensive, the principle difficulties arise from their low abundance, which creates significant issues of sustainability if the technology is to be adopted. The aim of this project is three-fold. Firstly, to further optimise the individual technologies using conventional transition metal complexes, with increases in efficiency leading to lower metal requirements. Secondly, to explore the periodic table for metal-containing luminophores based on first row transition metals, with an emphasis upon copper and zinc containing species. The final aspect is related to the utilization of solar derived electrons for water splitting reactions, allowing the generation of hydrogen and/or reaction products of hydrogen with organic species. This latter aspect is related to the mid-term requirement for liquid fuels, regardless of the primary fuel sources utilized. The program will involve design and synthesis of new materials, device construction and evaluation (in-house and with existing academic and industrial partners) and iterative refinement of structures
Max ERC Funding
2 399 440 €
Duration
Start date: 2011-01-01, End date: 2015-12-31
Project acronym LIQRISK
Project Liquidity and Risk in Macroeconomic Models
Researcher (PI) Philippe Jean Louis Bacchetta
Host Institution (HI) UNIVERSITE DE LAUSANNE
Call Details Advanced Grant (AdG), SH1, ERC-2010-AdG_20100407
Summary The proposal is motivated by the need to incorporate financial realities into macroeconomic models. The objective is to introduce leverage and liquidity in standard dynamic general equilibrium models and analyze their macroeconomic implications. The proposal is divided into two sub-projects and analyzes two different aspects of liquidity. The first deals with leverage and market liquidity in developed financial economies. The second examines the demand for liquid assets by emerging countries and its global implications. In the first sub-project, the proposal breaks new ground in the understanding of the dynamics of risk and in explaining some important features of the recent crisis. The project particularly emphasizes the role of self-fulfilling changes in expectations that can lead to sudden large shifts in risk. This can take the form of a financial panic with a big drop in asset prices. Various extensions will investigate the empirical implications as well as the implications for international capital flows, exchange rates, macroeconomic activity and policy recommendations. In the second sub-project, the objective is to formalize and analyze different degrees of liquidity in international capital flows. The project will innovate in finding ways to model liquidity in dynamic open economy models. This will allow a better understanding of the recent pattern in international capital flows, where less developed countries lend to richer economies. It will also shed light on the evolution of global imbalances before and after the crisis.
Summary
The proposal is motivated by the need to incorporate financial realities into macroeconomic models. The objective is to introduce leverage and liquidity in standard dynamic general equilibrium models and analyze their macroeconomic implications. The proposal is divided into two sub-projects and analyzes two different aspects of liquidity. The first deals with leverage and market liquidity in developed financial economies. The second examines the demand for liquid assets by emerging countries and its global implications. In the first sub-project, the proposal breaks new ground in the understanding of the dynamics of risk and in explaining some important features of the recent crisis. The project particularly emphasizes the role of self-fulfilling changes in expectations that can lead to sudden large shifts in risk. This can take the form of a financial panic with a big drop in asset prices. Various extensions will investigate the empirical implications as well as the implications for international capital flows, exchange rates, macroeconomic activity and policy recommendations. In the second sub-project, the objective is to formalize and analyze different degrees of liquidity in international capital flows. The project will innovate in finding ways to model liquidity in dynamic open economy models. This will allow a better understanding of the recent pattern in international capital flows, where less developed countries lend to richer economies. It will also shed light on the evolution of global imbalances before and after the crisis.
Max ERC Funding
2 070 570 €
Duration
Start date: 2011-08-01, End date: 2016-07-31
Project acronym MACI
Project Moduli, Algebraic Cycles, and Invariants
Researcher (PI) Rahul Vijay PANDHARIPANDE
Host Institution (HI) EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Call Details Advanced Grant (AdG), PE1, ERC-2017-ADG
Summary Algebraic geometry is the study of varieties -- the zero sets of polynomial equations in several variables. The subject has a central role in mathematics with connections to number theory, representation theory, and topology. Moduli questions in algebraic geometry concern the behavior of varieties as the coefficients of the defining polynomials vary. At the end of the 20th century, several basic links between the algebraic geometry of moduli spaces and path integrals in quantum field theory were made. The virtual fundamental class plays an essential role in these connections. I propose to study the algebraic cycle theory of basic moduli spaces. The guiding questions are: What are the most important cycles? What is the structure of the algebra of cycles? How can the classes of geometric loci be expressed? The virtual fundamental class and the associated invariants often control the answers. A combination of virtual localization, degeneration, and R-matrix methods together with new ideas from log geometry will be used in the study.
Most of the basic moduli spaces in algebraic geometry related to varieties of dimension at most 3 -- including the moduli of curves, the moduli of maps, the moduli of surfaces, and the moduli of sheaves on 3-folds -- will be considered. The current state of the study of the algebraic cycle theory in these cases varies from rather advanced (for the moduli of curves) to much less so (for the moduli of surfaces). There is a range of rich open questions which I will attack: Pixton's conjectures for the moduli of curves, the structure of the ring of Noether-Lefschetz loci for the moduli of K3 surfaces, the holomorphic anomaly equation in Gromov-Witten theory, and conjectures governing descendents for the moduli of sheaves. The dimension 3 restriction is often necessary for a good deformation theory and the existence of a virtual fundamental class.
Summary
Algebraic geometry is the study of varieties -- the zero sets of polynomial equations in several variables. The subject has a central role in mathematics with connections to number theory, representation theory, and topology. Moduli questions in algebraic geometry concern the behavior of varieties as the coefficients of the defining polynomials vary. At the end of the 20th century, several basic links between the algebraic geometry of moduli spaces and path integrals in quantum field theory were made. The virtual fundamental class plays an essential role in these connections. I propose to study the algebraic cycle theory of basic moduli spaces. The guiding questions are: What are the most important cycles? What is the structure of the algebra of cycles? How can the classes of geometric loci be expressed? The virtual fundamental class and the associated invariants often control the answers. A combination of virtual localization, degeneration, and R-matrix methods together with new ideas from log geometry will be used in the study.
Most of the basic moduli spaces in algebraic geometry related to varieties of dimension at most 3 -- including the moduli of curves, the moduli of maps, the moduli of surfaces, and the moduli of sheaves on 3-folds -- will be considered. The current state of the study of the algebraic cycle theory in these cases varies from rather advanced (for the moduli of curves) to much less so (for the moduli of surfaces). There is a range of rich open questions which I will attack: Pixton's conjectures for the moduli of curves, the structure of the ring of Noether-Lefschetz loci for the moduli of K3 surfaces, the holomorphic anomaly equation in Gromov-Witten theory, and conjectures governing descendents for the moduli of sheaves. The dimension 3 restriction is often necessary for a good deformation theory and the existence of a virtual fundamental class.
Max ERC Funding
2 496 055 €
Duration
Start date: 2018-09-01, End date: 2023-08-31
Project acronym MATHCARD
Project Mathematical Modelling and Simulation of the Cardiovascular System
Researcher (PI) Alfio Quarteroni
Host Institution (HI) ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Call Details Advanced Grant (AdG), PE1, ERC-2008-AdG
Summary This research project aims at the development, analysis and computer implementation of mathematical models of the cardiovascular system. Our goal is to describe and simulate the anatomic structure and the physiological response of the human cardiovascular system in healthy or diseased states. This demands to address many fundamental issues. Blood flow interacts both mechanically and chemically with the vessel walls and tissue, giving rise to complex fluid-structure interaction problems. The mathematical analysis of these problems is complicated and the related numerical analysis difficult. We propose to extend the recently achieved results on blood flow simulations by directing our analysis in several new directions. Our goal is to encompass aspects of metabolic regulation, micro-circulation, the electrical and mechanical activity of the heart, and their interactions. Modelling and optimisation of drugs delivery in clinical diseases will be addressed as well. This requires the understanding of transport, diffusion and reaction processes within the blood and organs of the body. The emphasis of this project will be put on mathematical modelling, numerical analysis, algorithm implementation, computational efficiency, validation and verification. Our purpose is to set up a mathematical simulation platform eventually leading to the improvement of vascular diseases diagnosis, setting up of surgical planning, and cure of inflammatory processes in the circulatory system. This platform might also help physicians to construct and evaluate combined anatomic/physiological models to predict the outcome of alternative treatment plans for individual patients.
Summary
This research project aims at the development, analysis and computer implementation of mathematical models of the cardiovascular system. Our goal is to describe and simulate the anatomic structure and the physiological response of the human cardiovascular system in healthy or diseased states. This demands to address many fundamental issues. Blood flow interacts both mechanically and chemically with the vessel walls and tissue, giving rise to complex fluid-structure interaction problems. The mathematical analysis of these problems is complicated and the related numerical analysis difficult. We propose to extend the recently achieved results on blood flow simulations by directing our analysis in several new directions. Our goal is to encompass aspects of metabolic regulation, micro-circulation, the electrical and mechanical activity of the heart, and their interactions. Modelling and optimisation of drugs delivery in clinical diseases will be addressed as well. This requires the understanding of transport, diffusion and reaction processes within the blood and organs of the body. The emphasis of this project will be put on mathematical modelling, numerical analysis, algorithm implementation, computational efficiency, validation and verification. Our purpose is to set up a mathematical simulation platform eventually leading to the improvement of vascular diseases diagnosis, setting up of surgical planning, and cure of inflammatory processes in the circulatory system. This platform might also help physicians to construct and evaluate combined anatomic/physiological models to predict the outcome of alternative treatment plans for individual patients.
Max ERC Funding
1 810 992 €
Duration
Start date: 2009-01-01, End date: 2014-06-30