Project acronym BIOQ
Project Diamond Quantum Devices and Biology
Researcher (PI) Fedor Jelezko
Host Institution (HI) UNIVERSITAET ULM
Call Details Synergy Grants (SyG), SYG6, ERC-2012-SyG
Summary Many of the most remarkable contributions of modern science to society have arisen from interdisciplinary work of scientists enabling novel imaging and sensing technologies (NMR, X-ray diffraction, electron microscopy). BioQ will revolutionize the state of the art to create novel sensing technologies for the broad field of life sciences research that provide unprecedented access and insight into structure and function of individual bio-molecules under physiological conditions and apply these to the observation of biological processes down to the quantum level and with atomic resolution. At this level quantum properties are predicted to play an important role for the function of biological systems subject to environmental noise. BioQ will unravel the interplay of quantum coherent dynamics, molecular vibrations and environmental noise due to molecular vibrations in biological processes and design and carry out experimental tests of its predictions. BioQ will achieve new levels of understanding and control of biological systems, culminating in new ways to interface biological systems with quantum devices. To this end BioQ will exploit the ability of biological systems to arrange themselves into highly ordered structures to form novel hybrid materials of functionalized nano-diamonds that are capable of harnessing complex quantum dynamics at room temperature.
A deeper understanding of biological processes will open new roads towards drug design and bio-imaging. The elucidation of energy transport processes and dynamics may pave the way towards the design of more efficient light harvesting systems. Self-assembled hybrid bio-quantum devices provide a novel perspective towards quantum nanotechnology. The broad challenges that this ambitious programme present will be solved by an interdisciplinary team led by three PIs from experimental solid-state physics, theoretical quantum physics and bio-chemistry whose combination of expertise is essential for the success of BioQ.
Summary
Many of the most remarkable contributions of modern science to society have arisen from interdisciplinary work of scientists enabling novel imaging and sensing technologies (NMR, X-ray diffraction, electron microscopy). BioQ will revolutionize the state of the art to create novel sensing technologies for the broad field of life sciences research that provide unprecedented access and insight into structure and function of individual bio-molecules under physiological conditions and apply these to the observation of biological processes down to the quantum level and with atomic resolution. At this level quantum properties are predicted to play an important role for the function of biological systems subject to environmental noise. BioQ will unravel the interplay of quantum coherent dynamics, molecular vibrations and environmental noise due to molecular vibrations in biological processes and design and carry out experimental tests of its predictions. BioQ will achieve new levels of understanding and control of biological systems, culminating in new ways to interface biological systems with quantum devices. To this end BioQ will exploit the ability of biological systems to arrange themselves into highly ordered structures to form novel hybrid materials of functionalized nano-diamonds that are capable of harnessing complex quantum dynamics at room temperature.
A deeper understanding of biological processes will open new roads towards drug design and bio-imaging. The elucidation of energy transport processes and dynamics may pave the way towards the design of more efficient light harvesting systems. Self-assembled hybrid bio-quantum devices provide a novel perspective towards quantum nanotechnology. The broad challenges that this ambitious programme present will be solved by an interdisciplinary team led by three PIs from experimental solid-state physics, theoretical quantum physics and bio-chemistry whose combination of expertise is essential for the success of BioQ.
Max ERC Funding
10 293 309 €
Duration
Start date: 2013-07-01, End date: 2019-06-30
Project acronym COMBATCANCER
Project Combination therapies for personalized cancer medicine
Researcher (PI) Michael Rudolf Stratton
Host Institution (HI) STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
Call Details Synergy Grants (SyG), SYG6, ERC-2012-SyG
Summary All cancers arise due to alterations in their genomes. Although insight into the genetic lesions in tumours by genome sequencing does already assist in selecting some drug regimens, it rarely results in disease eradication due to the emergence of drug-resistant clones. More sophisticated combination therapies in which several oncogenic pathways are targeted simultaneously or in a particular sequence are believed to hold more promise. However, at present we are unable to extract and interpret the necessary information from tumours to predict which drug regimen will be most adequate. The genetic make-up of the individual, the heterogeneity of the tumour, epigenetic alterations, cell-of-origin of the tumour, and complex interactions between tumour cells and stromal cells appear important confounding factors influencing response. In addition, we are still ignorant of many of the intricate complexities of signalling networks in cells and how tumours exploit these to acquire drug resistance.
It is the ambition of the team formed by members of the Netherlands Cancer Institute (NKI) and the Cancer Genome Project at the Wellcome Trust Sanger Institute (WTSI) to unravel the genomic and phenotypic complexity of human cancers in order to identify optimal drug combinations for personalized cancer therapy. Our integrated approach will entail (i) deep sequencing of human tumours and cognate mouse tumours; (ii) drug screens in a 1000+ fully characterized tumour cell line panel; (iii) high-throughput in vitro and in vivo shRNA and cDNA drug resistance and enhancement screens; (iv) computational analysis of the acquired data, leading to significant response predictions; (v) rigorous validation of these predictions in genetically engineered mouse models and patient-derived xenografts. This integrated effort is expected to yield a number of combination therapies and companion-diagnostics biomarkers that will be further explored in our existing clinical trial networks.
Summary
All cancers arise due to alterations in their genomes. Although insight into the genetic lesions in tumours by genome sequencing does already assist in selecting some drug regimens, it rarely results in disease eradication due to the emergence of drug-resistant clones. More sophisticated combination therapies in which several oncogenic pathways are targeted simultaneously or in a particular sequence are believed to hold more promise. However, at present we are unable to extract and interpret the necessary information from tumours to predict which drug regimen will be most adequate. The genetic make-up of the individual, the heterogeneity of the tumour, epigenetic alterations, cell-of-origin of the tumour, and complex interactions between tumour cells and stromal cells appear important confounding factors influencing response. In addition, we are still ignorant of many of the intricate complexities of signalling networks in cells and how tumours exploit these to acquire drug resistance.
It is the ambition of the team formed by members of the Netherlands Cancer Institute (NKI) and the Cancer Genome Project at the Wellcome Trust Sanger Institute (WTSI) to unravel the genomic and phenotypic complexity of human cancers in order to identify optimal drug combinations for personalized cancer therapy. Our integrated approach will entail (i) deep sequencing of human tumours and cognate mouse tumours; (ii) drug screens in a 1000+ fully characterized tumour cell line panel; (iii) high-throughput in vitro and in vivo shRNA and cDNA drug resistance and enhancement screens; (iv) computational analysis of the acquired data, leading to significant response predictions; (v) rigorous validation of these predictions in genetically engineered mouse models and patient-derived xenografts. This integrated effort is expected to yield a number of combination therapies and companion-diagnostics biomarkers that will be further explored in our existing clinical trial networks.
Max ERC Funding
14 580 558 €
Duration
Start date: 2013-05-01, End date: 2019-04-30
Project acronym DD.POP
Project Domestic Devotions: The Place of Piety in the Renaissance Italian Home
Researcher (PI) Abigail Sarah Brundin
Host Institution (HI) THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Call Details Synergy Grants (SyG), SYG6, ERC-2012-SyG
Summary Domestic Devotions brings together the study of books, buildings, objects, spaces, images and archives in order to understand how religion functioned in the Renaissance household. In opposition to the enduring stereotype of the Renaissance as a ‘secular age’, our research is premised on the view that religion played a key role in attending to the needs of the laity, and presents the period 1400-1600 as an age of spiritual revitalization. Devotions, from routine prayers to extraordinary religious experiences such as miracles or exorcisms, frequently took place within the home and were specifically shaped to meet the demands of domestic life – childbirth, marriage, infertility, sickness, accidents, poverty and death. This tight bond between the domestic and the devotional was neither institutionally nor legally defined. It cannot be adequately traced in any one type of source nor by means of a single approach. A rare combination of expertise and experience across several disciplines – social history, textual scholarship, and the study of art and architecture – is required to reveal the pivotal place of piety in the Renaissance home.
The project moves beyond traditional research on the Renaissance in two further ways. Firstly, it breaks free from the golden triangle of Venice, Florence and Rome in order to investigate practices of piety in three significant zones: Naples and its environs; the Marche in central Italy; and the Venetian mainland. Secondly, it rejects the standard focus on Renaissance elites in order to develop our understanding of the artisanal household. Inspired in part by the rich historiography on the Protestant family, Domestic Devotions will shed new light on the roles of women and children in the Catholic home, and will be attentive to gender and age as factors that conditioned religious experience. Our multidisciplinary approach will enable unprecedented glimpses into the private lives of Renaissance Italians.
Summary
Domestic Devotions brings together the study of books, buildings, objects, spaces, images and archives in order to understand how religion functioned in the Renaissance household. In opposition to the enduring stereotype of the Renaissance as a ‘secular age’, our research is premised on the view that religion played a key role in attending to the needs of the laity, and presents the period 1400-1600 as an age of spiritual revitalization. Devotions, from routine prayers to extraordinary religious experiences such as miracles or exorcisms, frequently took place within the home and were specifically shaped to meet the demands of domestic life – childbirth, marriage, infertility, sickness, accidents, poverty and death. This tight bond between the domestic and the devotional was neither institutionally nor legally defined. It cannot be adequately traced in any one type of source nor by means of a single approach. A rare combination of expertise and experience across several disciplines – social history, textual scholarship, and the study of art and architecture – is required to reveal the pivotal place of piety in the Renaissance home.
The project moves beyond traditional research on the Renaissance in two further ways. Firstly, it breaks free from the golden triangle of Venice, Florence and Rome in order to investigate practices of piety in three significant zones: Naples and its environs; the Marche in central Italy; and the Venetian mainland. Secondly, it rejects the standard focus on Renaissance elites in order to develop our understanding of the artisanal household. Inspired in part by the rich historiography on the Protestant family, Domestic Devotions will shed new light on the roles of women and children in the Catholic home, and will be attentive to gender and age as factors that conditioned religious experience. Our multidisciplinary approach will enable unprecedented glimpses into the private lives of Renaissance Italians.
Max ERC Funding
2 333 162 €
Duration
Start date: 2013-09-01, End date: 2017-08-31
Project acronym DHCP
Project The Developing Human Connectome Project
Researcher (PI) Joseph Vilmos Hajnal
Host Institution (HI) KING'S COLLEGE LONDON
Call Details Synergy Grants (SyG), SYG6, ERC-2012-SyG
Summary Few advances in neuroscience could have as much impact as a precise global description of human brain connectivity and its variability. Understanding this ‘connectome’ in detail will provide insights into fundamental neural processes and intractable neuropsychiatric diseases.
The connectome can be studied at millimetre scale in humans by neuroimaging, particularly diffusion and functional connectivity Magnetic Resonance Imaging. By linking imaging data to genetic, cognitive and environmental information it will be possible to answer previously unsolvable questions concerning normal mental functioning and intractable neuropsychiatric diseases.
Current human connectome research relates almost exclusively to the mature brain. However mental capacity and neurodevelopmental diseases are created during early development. Advances in fetal and neonatal Magnetic Resonance Imaging now allow us to undertake The Developing Human Connectome Project (dHCP) which will make major scientific progress by: creating the first 4-dimensional connectome of early life; and undertake pioneer studies into normal and abnormal development.
The dHCP will deliver:
• the first dynamic map of human brain connectivity from 20 to 44 weeks post-conceptional age, linked to imaging, clinical, behavioural and genetic information;
• comparative maps of the cerebral connectivity associated with neurodevelopmental abnormality, studying well-characterized patients with either the adverse environmental influence of preterm delivery or genetically-characterised Autistic Spectrum Disorder; and
• novel imaging and analysis methods in an open-source, outward-facing expandable informatics environment that will provide a scalable resource for the research community and advances in clinical medicine.
Summary
Few advances in neuroscience could have as much impact as a precise global description of human brain connectivity and its variability. Understanding this ‘connectome’ in detail will provide insights into fundamental neural processes and intractable neuropsychiatric diseases.
The connectome can be studied at millimetre scale in humans by neuroimaging, particularly diffusion and functional connectivity Magnetic Resonance Imaging. By linking imaging data to genetic, cognitive and environmental information it will be possible to answer previously unsolvable questions concerning normal mental functioning and intractable neuropsychiatric diseases.
Current human connectome research relates almost exclusively to the mature brain. However mental capacity and neurodevelopmental diseases are created during early development. Advances in fetal and neonatal Magnetic Resonance Imaging now allow us to undertake The Developing Human Connectome Project (dHCP) which will make major scientific progress by: creating the first 4-dimensional connectome of early life; and undertake pioneer studies into normal and abnormal development.
The dHCP will deliver:
• the first dynamic map of human brain connectivity from 20 to 44 weeks post-conceptional age, linked to imaging, clinical, behavioural and genetic information;
• comparative maps of the cerebral connectivity associated with neurodevelopmental abnormality, studying well-characterized patients with either the adverse environmental influence of preterm delivery or genetically-characterised Autistic Spectrum Disorder; and
• novel imaging and analysis methods in an open-source, outward-facing expandable informatics environment that will provide a scalable resource for the research community and advances in clinical medicine.
Max ERC Funding
14 974 313 €
Duration
Start date: 2013-09-01, End date: 2019-08-31
Project acronym HETERO2D
Project Novel materials architecture based on atomically thin crystals
Researcher (PI) Andrea Ferrari
Host Institution (HI) THE UNIVERSITY OF MANCHESTER
Call Details Synergy Grants (SyG), SYG6, ERC-2012-SyG
Summary We propose a new paradigm in materials science – heterostructures based on two-dimensional atomic crystals (and their hybrids with metallic and semiconducting quantum dots and nanostructures), and develop several devices which are based on such concept. Two-dimensional (2D) atomic crystals (such as graphene, monolayers of boron nitride, molybdenum disulphide, etc) possess a number of exciting properties, which are often unique and very different from those of their tree-dimensional counterparts. However, it is the combinations of such 2D crystals in 3D stacks that offer truly unlimited opportunities in designing the functionalities of such heterostructures. One can combine conductive, insulating, probably superconducting and magnetic 2D materials in one stack with atomic precision, fine-tuning the performance of the resulting material. Furthermore, the functionality of such stacks is “embedded” in the design of such heterostructure. We will create several types of devices based on such heterostructures, including tunnelling transistors, charge and spin drag, photodetectors, solarcells, lasers and other optical and electronic components. As the range of available 2D materials broadens, so the possible functionality of the 2D-based heterostructures will cover larger and larger area. We will concentrate on creating and understanding of the prototypes of such hetersotructures and apply efforts in developing methods for their mass-production suitable for various applications. The development of such novel paradigm in material science will only by possible by bringing together a Synergy group of researchers with complementary skills, knowledge and resources.
Summary
We propose a new paradigm in materials science – heterostructures based on two-dimensional atomic crystals (and their hybrids with metallic and semiconducting quantum dots and nanostructures), and develop several devices which are based on such concept. Two-dimensional (2D) atomic crystals (such as graphene, monolayers of boron nitride, molybdenum disulphide, etc) possess a number of exciting properties, which are often unique and very different from those of their tree-dimensional counterparts. However, it is the combinations of such 2D crystals in 3D stacks that offer truly unlimited opportunities in designing the functionalities of such heterostructures. One can combine conductive, insulating, probably superconducting and magnetic 2D materials in one stack with atomic precision, fine-tuning the performance of the resulting material. Furthermore, the functionality of such stacks is “embedded” in the design of such heterostructure. We will create several types of devices based on such heterostructures, including tunnelling transistors, charge and spin drag, photodetectors, solarcells, lasers and other optical and electronic components. As the range of available 2D materials broadens, so the possible functionality of the 2D-based heterostructures will cover larger and larger area. We will concentrate on creating and understanding of the prototypes of such hetersotructures and apply efforts in developing methods for their mass-production suitable for various applications. The development of such novel paradigm in material science will only by possible by bringing together a Synergy group of researchers with complementary skills, knowledge and resources.
Max ERC Funding
13 352 308 €
Duration
Start date: 2013-11-01, End date: 2019-10-31
Project acronym I2MOVE
Project An Intelligent Implantable MOdulator of Vagus nervE function for treatment of Obesity
Researcher (PI) Steve Bloom
Host Institution (HI) IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Call Details Synergy Grants (SyG), SYG6, ERC-2012-SyG
Summary Obesity is one of the greatest public health challenges of the 21st century. Affecting over half a billion people worldwide, it increases the risk of stroke, ischaemic heart disease, diabetes, many cancers, depression and complications in pregnancy. Bariatric surgery is currently the only effective treatment available but is associated with significant risks of mortality and long-term complications. New and innovative treatments are thus required.
The signals to and from the gut during eating and digestion are passed through the vagus nerve. Despite this, our knowledge of vagus nerve function comes from studies in which the nerve is cut. This fails to provide any impression of the complex signal received by appetite centres in the brain.
We propose to use obesity as a paradigm for development of a new generation of neural interface that will combine novel electrode materials, structures and sensing modalities with ultra-low power electronic neural recording, analysis, stimulation and wireless communication. Several steps beyond state-of-the-art, this will allow, for the first time, detailed study of the entirety of vagus nerve function. We will develop neural stimulation that mimics the response of the vagus nerve to ingestion of food, thus providing a new treatment for obesity.
The synergy between our groups will thus combine complementary interests to develop an innovative technological solution for a major public health crisis. The sensing capability will deliver, for the first time, real-time and long-term recordings, providing new insights into peripheral nerve activity. The impact will thus extend beyond appetite and the vagus to many other neurally regulated processes and diseases.
Summary
Obesity is one of the greatest public health challenges of the 21st century. Affecting over half a billion people worldwide, it increases the risk of stroke, ischaemic heart disease, diabetes, many cancers, depression and complications in pregnancy. Bariatric surgery is currently the only effective treatment available but is associated with significant risks of mortality and long-term complications. New and innovative treatments are thus required.
The signals to and from the gut during eating and digestion are passed through the vagus nerve. Despite this, our knowledge of vagus nerve function comes from studies in which the nerve is cut. This fails to provide any impression of the complex signal received by appetite centres in the brain.
We propose to use obesity as a paradigm for development of a new generation of neural interface that will combine novel electrode materials, structures and sensing modalities with ultra-low power electronic neural recording, analysis, stimulation and wireless communication. Several steps beyond state-of-the-art, this will allow, for the first time, detailed study of the entirety of vagus nerve function. We will develop neural stimulation that mimics the response of the vagus nerve to ingestion of food, thus providing a new treatment for obesity.
The synergy between our groups will thus combine complementary interests to develop an innovative technological solution for a major public health crisis. The sensing capability will deliver, for the first time, real-time and long-term recordings, providing new insights into peripheral nerve activity. The impact will thus extend beyond appetite and the vagus to many other neurally regulated processes and diseases.
Max ERC Funding
7 175 339 €
Duration
Start date: 2013-04-01, End date: 2018-11-30
Project acronym NEXUS1492
Project NEXUS 1492. New World Encounters in a Globalising World
Researcher (PI) Gareth Rees Davies
Host Institution (HI) UNIVERSITEIT LEIDEN
Call Details Synergy Grants (SyG), SYG6, ERC-2012-SyG
Summary NEXUS1492 investigates the impacts of colonial encounters in the Caribbean, the nexus of the first interactions between the New and the Old World. This Synergy Programme intends to rewrite a crucial and neglected chapter in global history initiated by European colonisation by focussing on transformations to indigenous, Amerindian cultures and societies. NEXUS1492 will address intercultural Amerindian-European-African dynamics at multiple temporal and spatial scales across the historical divide of 1492. The unique trans-disciplinary synergy of four PIs and their teams of archaeologists, social, natural and computer scientists, and heritage experts will pioneer new analytical tools, and apply multi-disciplinary cutting-edge techniques, theoretical frameworks and skill sets to provide a novel perspective on New World encounters in a globalising world. NEXUS1492 will work with local experts to develop sustainable heritage management strategies, creating a future for the past. This past is under threat from looting and illegal trade, construction development and natural disasters (e.g., climate change, earthquakes, and volcanic eruptions). By placing the Caribbean’s indigenous past within a contemporary heritage agenda, this programme strives to increase the awareness and protection of heritage resources. The innovative approach and outcomes of NEXUS1492 will be of global scientific significance and high societal relevance.
Four interlocking projects will address:
1. Transformations of lifeways and deathways, landscapes, and material culture through archaeological investigations.
2. Human mobility and the circulation of materials and objects through isotope geochemistry and archaeometry.
3.Socio-cultural relationships and interactions through the reconstruction of archaeological networks.
4. Heritage preservation through investigation of regulatory, legislative, and curatorial standards and community engagement efforts.
Summary
NEXUS1492 investigates the impacts of colonial encounters in the Caribbean, the nexus of the first interactions between the New and the Old World. This Synergy Programme intends to rewrite a crucial and neglected chapter in global history initiated by European colonisation by focussing on transformations to indigenous, Amerindian cultures and societies. NEXUS1492 will address intercultural Amerindian-European-African dynamics at multiple temporal and spatial scales across the historical divide of 1492. The unique trans-disciplinary synergy of four PIs and their teams of archaeologists, social, natural and computer scientists, and heritage experts will pioneer new analytical tools, and apply multi-disciplinary cutting-edge techniques, theoretical frameworks and skill sets to provide a novel perspective on New World encounters in a globalising world. NEXUS1492 will work with local experts to develop sustainable heritage management strategies, creating a future for the past. This past is under threat from looting and illegal trade, construction development and natural disasters (e.g., climate change, earthquakes, and volcanic eruptions). By placing the Caribbean’s indigenous past within a contemporary heritage agenda, this programme strives to increase the awareness and protection of heritage resources. The innovative approach and outcomes of NEXUS1492 will be of global scientific significance and high societal relevance.
Four interlocking projects will address:
1. Transformations of lifeways and deathways, landscapes, and material culture through archaeological investigations.
2. Human mobility and the circulation of materials and objects through isotope geochemistry and archaeometry.
3.Socio-cultural relationships and interactions through the reconstruction of archaeological networks.
4. Heritage preservation through investigation of regulatory, legislative, and curatorial standards and community engagement efforts.
Max ERC Funding
14 826 037 €
Duration
Start date: 2013-09-01, End date: 2019-08-31
Project acronym Q-MAC
Project Frontiers in Quantum Materials Control
Researcher (PI) Jean-Marc Serge Thierry Triscone
Host Institution (HI) MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Call Details Synergy Grants (SyG), SYG6, ERC-2012-SyG
Summary The overarching goal of the present proposal is to exploit materials design, coherent optical methods and multiple theoretical approaches to deterministically control ordered states of strongly correlated electron materials, also referred to as “quantum” or “complex” materials. The underlying ideas can be applied to vast number of problems in materials physics, but the stated goal is that of optimizing superconductivity at higher temperatures than achieved so far, possibly even at room temperature. The proposal starts from research strands that follow challenging but well-establish paths, such as the use of complex-oxide heterostructures and strain engineering at interfaces to modulate the electronic properties. In a second class of investigations, coherent optical control of lattice dynamics with strong field THz transients is proposed to “anneal” the competing order quenching superconductivity. This builds on our recent discovery of light-induced transient superconductivity in high temperature cuprates, a remarkable process not yet understood or optimized. We will use a combination of femtosecond optical and x-ray experiments with Free Electron Lasers, together with time dependent real-materials simulations. Perhaps the most ambitious goal will be to develop laser-cooling techniques to reduce quantum phase fluctuations between planes of cuprate superconductors. Finally, we propose to use static and dynamic techniques to engineer new phases of condensed matter, for example by engineering new materials with a single band crossing the Fermi level, to optimize superconductivity. A unique combination of complementary expertise, from materials design, to coherent and ultrafast optical and x-ray physics, with materials and quantum optics theory, will be key in making true progress in these areas.
Summary
The overarching goal of the present proposal is to exploit materials design, coherent optical methods and multiple theoretical approaches to deterministically control ordered states of strongly correlated electron materials, also referred to as “quantum” or “complex” materials. The underlying ideas can be applied to vast number of problems in materials physics, but the stated goal is that of optimizing superconductivity at higher temperatures than achieved so far, possibly even at room temperature. The proposal starts from research strands that follow challenging but well-establish paths, such as the use of complex-oxide heterostructures and strain engineering at interfaces to modulate the electronic properties. In a second class of investigations, coherent optical control of lattice dynamics with strong field THz transients is proposed to “anneal” the competing order quenching superconductivity. This builds on our recent discovery of light-induced transient superconductivity in high temperature cuprates, a remarkable process not yet understood or optimized. We will use a combination of femtosecond optical and x-ray experiments with Free Electron Lasers, together with time dependent real-materials simulations. Perhaps the most ambitious goal will be to develop laser-cooling techniques to reduce quantum phase fluctuations between planes of cuprate superconductors. Finally, we propose to use static and dynamic techniques to engineer new phases of condensed matter, for example by engineering new materials with a single band crossing the Fermi level, to optimize superconductivity. A unique combination of complementary expertise, from materials design, to coherent and ultrafast optical and x-ray physics, with materials and quantum optics theory, will be key in making true progress in these areas.
Max ERC Funding
9 966 873 €
Duration
Start date: 2013-10-01, End date: 2019-09-30
Project acronym QC-LAB
Project Quantum Computer Lab
Researcher (PI) Carlo Willem Joannes Beenakker
Host Institution (HI) TECHNISCHE UNIVERSITEIT DELFT
Call Details Synergy Grants (SyG), SYG6, ERC-2012-SyG
Summary The world of atoms is governed by the rules of quantum mechanics. Over the past century, quantum-mechanical phenomena such as superposition and entanglement have been observed and studied with great precision. Today, we are entering a new era in which we can hope to explore quantum mechanics in larger objects. The science of quantum mechanics in more complex objects is barely known and as a result quantum mechanics is rarely explicitly used in technology. Theoretically, superposition and entanglement could be exploited as a new resource in a wide variety of future applications. We focus on information science and investigate the use of quantum mechanics in computing, i.e. a quantum computer (QC). If information is encoded in quantum superpositions and processed by exploiting entanglement, a QC can solve computational problems that are beyond the reach of conventional computers. Building a QC is, however, an enormous scientific challenge because the fragile quantum bits need to be protected from and corrected for even the smallest disturbances by the environment. Meeting this challenge requires a synergetic effort combining the best of quantum theory, electrical engineering, materials science, applied physics and computer science. This proposal aims to achieve a robust, exemplary QC. We propose a circuit containing processor qubits (two types: superconducting transmon qubits and spin qubits in silicon quantum dots), memory qubits (two types: topological qubits with nanowires and donor qubits), and a quantum databus (superconducting striplines). Our goal is to demonstrate a 13-qubit circuit that incorporates fault-tolerance through implementation of a surface code. We will demonstrate back-and-forth quantum state transfer between processor and memory qubits. Our team brings together the required expertise into a single “QC-lab” enabling us to bring our understanding of quantum mechanics to the next level and push QC to the tipping point from science to engineering.
Summary
The world of atoms is governed by the rules of quantum mechanics. Over the past century, quantum-mechanical phenomena such as superposition and entanglement have been observed and studied with great precision. Today, we are entering a new era in which we can hope to explore quantum mechanics in larger objects. The science of quantum mechanics in more complex objects is barely known and as a result quantum mechanics is rarely explicitly used in technology. Theoretically, superposition and entanglement could be exploited as a new resource in a wide variety of future applications. We focus on information science and investigate the use of quantum mechanics in computing, i.e. a quantum computer (QC). If information is encoded in quantum superpositions and processed by exploiting entanglement, a QC can solve computational problems that are beyond the reach of conventional computers. Building a QC is, however, an enormous scientific challenge because the fragile quantum bits need to be protected from and corrected for even the smallest disturbances by the environment. Meeting this challenge requires a synergetic effort combining the best of quantum theory, electrical engineering, materials science, applied physics and computer science. This proposal aims to achieve a robust, exemplary QC. We propose a circuit containing processor qubits (two types: superconducting transmon qubits and spin qubits in silicon quantum dots), memory qubits (two types: topological qubits with nanowires and donor qubits), and a quantum databus (superconducting striplines). Our goal is to demonstrate a 13-qubit circuit that incorporates fault-tolerance through implementation of a surface code. We will demonstrate back-and-forth quantum state transfer between processor and memory qubits. Our team brings together the required expertise into a single “QC-lab” enabling us to bring our understanding of quantum mechanics to the next level and push QC to the tipping point from science to engineering.
Max ERC Funding
15 000 000 €
Duration
Start date: 2013-11-01, End date: 2019-10-31
Project acronym TOPAG
Project Toxic protein aggregation in neurodegeneration
Researcher (PI) Paul Wolfgang Baumeister
Host Institution (HI) MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Call Details Synergy Grants (SyG), SYG6, ERC-2012-SyG
Summary Formation of amyloid-like protein aggregates is the hallmark of a number of neurodegenerative diseases, but how the aggregation process is linked with cytotoxicity and cell death remains unclear. The goal of this pro¬ject is to elucidate the basic mechanisms of aggregate toxicity and how it affects the biological system in its entirety. We will analyse cell culture and mouse models of Huntington’s disease, amyotrophic lateral sclero¬sis and Alzheimer’s disease using a trans-disciplinary approach combining cellular biochemistry, quantita¬tive proteomics and 3D cryo-electron tomography. The effects of aggregating protein species (APS) formed by designer proteins and authentic disease proteins will be compared to define general and disease-specific toxicity mechanisms. The main aims of this project are:
1. To determine the sequence of cellular events occurring during toxic protein aggregation. Live cell imaging and single molecule fluorescence fluctuation measurements will be employed to monitor how APS evolve from diffusible oligomers to large inclusions and quantitative proteomics will define signatures for cells with different forms of aggregates.
2. To identify the mechanisms of aggregation toxicity through a systematic interactome analysis of APS in cell culture and mouse brain. The cellular localization of APS and their potential association with membrane structures and cellular machinery will be determined by cryo-ET.
3. To elucidate why cellular protein quality control fails in neurodegenerative disease. Specially designed proteostasis sensors will be used to monitor the status of the protein folding machinery as aggregate pathol¬ogy develops. The potentially protective pathways of inclusion body formation will be explored using cryo-ET and laser capture dissection coupled with highly sensitive proteomics.
Understanding aggregation toxicity will be invaluable in developing novel therapeutic strategies for some of the most debilitating diseases of our time.
Summary
Formation of amyloid-like protein aggregates is the hallmark of a number of neurodegenerative diseases, but how the aggregation process is linked with cytotoxicity and cell death remains unclear. The goal of this pro¬ject is to elucidate the basic mechanisms of aggregate toxicity and how it affects the biological system in its entirety. We will analyse cell culture and mouse models of Huntington’s disease, amyotrophic lateral sclero¬sis and Alzheimer’s disease using a trans-disciplinary approach combining cellular biochemistry, quantita¬tive proteomics and 3D cryo-electron tomography. The effects of aggregating protein species (APS) formed by designer proteins and authentic disease proteins will be compared to define general and disease-specific toxicity mechanisms. The main aims of this project are:
1. To determine the sequence of cellular events occurring during toxic protein aggregation. Live cell imaging and single molecule fluorescence fluctuation measurements will be employed to monitor how APS evolve from diffusible oligomers to large inclusions and quantitative proteomics will define signatures for cells with different forms of aggregates.
2. To identify the mechanisms of aggregation toxicity through a systematic interactome analysis of APS in cell culture and mouse brain. The cellular localization of APS and their potential association with membrane structures and cellular machinery will be determined by cryo-ET.
3. To elucidate why cellular protein quality control fails in neurodegenerative disease. Specially designed proteostasis sensors will be used to monitor the status of the protein folding machinery as aggregate pathol¬ogy develops. The potentially protective pathways of inclusion body formation will be explored using cryo-ET and laser capture dissection coupled with highly sensitive proteomics.
Understanding aggregation toxicity will be invaluable in developing novel therapeutic strategies for some of the most debilitating diseases of our time.
Max ERC Funding
13 927 098 €
Duration
Start date: 2013-06-01, End date: 2019-05-31
Project acronym UQUAM
Project Ultracold Quantum Matter
Researcher (PI) Jean Bernard Dalibard
Host Institution (HI) MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Call Details Synergy Grants (SyG), SYG6, ERC-2012-SyG
Summary Quantum mechanics is the basis of our understanding of the microscopic world. It is also central to the collective behaviour of matter at low temperatures, leading to unique properties that defy our classical intuition. The comprehension of such ‘quantum matter’ and the ability to master it using a newly developing set of ‘quantum technologies’ is not only of fundamental interest but holds the promise of revolutionizing material and information science as well as metrology. Our aim is to take this interdisciplinary research field to a qualitatively new level, by taking advantage of the most recent spectacular advances in the control of ultracold atomic and molecular systems. To this end, we have gathered a team of PIs with well-recognized and complementary expertise in the domains of quantum optics, atomic and condensed matter physics, and information science.
Our project is structured around three grand challenges: (i) Produce, understand and classify novel states of matter, including strongly correlated and topological quantum phases, and establish connections with simulation of field theories; (ii) Explore novel aspects of many-body dynamics, identify its universal regimes, and implement new classes of dissipative evolution; (iii) Engineer quantum matter to propose and implement new paradigms for information processing. We believe that only a joint effort, combining experimental tools beyond the state-of-the-art and novel theoretical approaches, will allow us to reach these outstanding goals. An essential element of the project, which will embody the synergy between the different perspectives brought by the PIs, will be the joint construction of an experiment employing transformative technologies. Our overall research program will allow us to address key questions on the nature of quantum matter and its potential high impact applications.
Summary
Quantum mechanics is the basis of our understanding of the microscopic world. It is also central to the collective behaviour of matter at low temperatures, leading to unique properties that defy our classical intuition. The comprehension of such ‘quantum matter’ and the ability to master it using a newly developing set of ‘quantum technologies’ is not only of fundamental interest but holds the promise of revolutionizing material and information science as well as metrology. Our aim is to take this interdisciplinary research field to a qualitatively new level, by taking advantage of the most recent spectacular advances in the control of ultracold atomic and molecular systems. To this end, we have gathered a team of PIs with well-recognized and complementary expertise in the domains of quantum optics, atomic and condensed matter physics, and information science.
Our project is structured around three grand challenges: (i) Produce, understand and classify novel states of matter, including strongly correlated and topological quantum phases, and establish connections with simulation of field theories; (ii) Explore novel aspects of many-body dynamics, identify its universal regimes, and implement new classes of dissipative evolution; (iii) Engineer quantum matter to propose and implement new paradigms for information processing. We believe that only a joint effort, combining experimental tools beyond the state-of-the-art and novel theoretical approaches, will allow us to reach these outstanding goals. An essential element of the project, which will embody the synergy between the different perspectives brought by the PIs, will be the joint construction of an experiment employing transformative technologies. Our overall research program will allow us to address key questions on the nature of quantum matter and its potential high impact applications.
Max ERC Funding
9 827 280 €
Duration
Start date: 2013-07-01, End date: 2019-06-30