Project acronym CSUMECH
Project Cholesterol and Sugar Uptake Mechanisms
Researcher (PI) Bjørn Pedersen
Host Institution (HI) AARHUS UNIVERSITET
Call Details Starting Grant (StG), LS1, ERC-2014-STG
Summary Cardiovascular disease, diabetes and cancer have a dramatic impact on modern society, and in great part are related to uptake of cholesterol and sugar. We still know surprisingly little about the molecular details of the processes that goes on in this essential part of human basic metabolism. This application addresses cholesterol and sugar transport and aim to elucidate the molecular mechanism of cholesterol and sugar uptake in humans. It moves the frontiers of the field by shifting the focus to in vitro work allowing hitherto untried structural and biochemical experiments to be performed.
Cholesterol uptake from the intestine is mediated by the membrane protein NPC1L1. Despite extensive research, the molecular mechanism of NPC1L1-dependent cholesterol uptake still remains largely unknown.
Facilitated sugar transport in humans is made possible by sugar transporters called GLUTs and SWEETs, and every cell possesses these sugar transport systems. For all these uptake systems structural information is sorely lacking to address important mechanistic questions to help elucidate their molecular mechanism.
I will address this using a complementary set of methods founded in macromolecular crystallography and electron microscopy to determine the 3-dimensional structures of key players in these uptake systems. My unpublished preliminary results have established the feasibility of this approach. This will be followed up by biochemical characterization of the molecular mechanism in vitro and in silico.
This high risk/high reward membrane protein proposal could lead to a breakthrough in how we approach human biochemical pathways that are linked to trans-membrane transport. An improved understanding of cholesterol and sugar homeostasis has tremendous potential for improving general public health, and furthermore this proposal will help to uncover general principles of endocytotic uptake and facilitated diffusion systems at the molecular level.
Summary
Cardiovascular disease, diabetes and cancer have a dramatic impact on modern society, and in great part are related to uptake of cholesterol and sugar. We still know surprisingly little about the molecular details of the processes that goes on in this essential part of human basic metabolism. This application addresses cholesterol and sugar transport and aim to elucidate the molecular mechanism of cholesterol and sugar uptake in humans. It moves the frontiers of the field by shifting the focus to in vitro work allowing hitherto untried structural and biochemical experiments to be performed.
Cholesterol uptake from the intestine is mediated by the membrane protein NPC1L1. Despite extensive research, the molecular mechanism of NPC1L1-dependent cholesterol uptake still remains largely unknown.
Facilitated sugar transport in humans is made possible by sugar transporters called GLUTs and SWEETs, and every cell possesses these sugar transport systems. For all these uptake systems structural information is sorely lacking to address important mechanistic questions to help elucidate their molecular mechanism.
I will address this using a complementary set of methods founded in macromolecular crystallography and electron microscopy to determine the 3-dimensional structures of key players in these uptake systems. My unpublished preliminary results have established the feasibility of this approach. This will be followed up by biochemical characterization of the molecular mechanism in vitro and in silico.
This high risk/high reward membrane protein proposal could lead to a breakthrough in how we approach human biochemical pathways that are linked to trans-membrane transport. An improved understanding of cholesterol and sugar homeostasis has tremendous potential for improving general public health, and furthermore this proposal will help to uncover general principles of endocytotic uptake and facilitated diffusion systems at the molecular level.
Max ERC Funding
1 499 848 €
Duration
Start date: 2015-07-01, End date: 2020-06-30
Project acronym RDRECON
Project Risky Decisions: Revealing Economic Behaviour
Researcher (PI) Steffen Andersen
Host Institution (HI) COPENHAGEN BUSINESS SCHOOL
Call Details Starting Grant (StG), SH1, ERC-2014-STG
Summary Households are exposed to a wide array of monetary and non-monetary risks: employment risk, financial risk, interest rate risk, and health and mortality risk, to name a few. Society and policymakers can certainly help households manage risk, but to be effective, they need to understand the ways households cope with risk and how vulnerable they are to market and policy changes. For instance, how do households react to bank defaults and market failures? How personal do these experiences have to be for households to change behavior? And how permanent are the changes in behavior?
The goal of the proposed research program is to understand how personal and market experiences affect financial decisions made by households, such as savings behavior, portfolio allocation, borrowing decisions, mortgage choices, and pension savings. RDRECON combines theory and evidence with an empirical research strategy that is comprised of both natural and field experiments. The theoretical component models how households make decisions. The empirical component uses both econometric and experimental methodologies to study actual household behavior across a range of economic and financial margins, as well as the influence of personal and market experiences on a household’s financial choices.
RDRECON’s strength and path-breaking innovation is its combination of administrative register data and controlled field experiments to form treatment and control groups of interest which allow empirical identification of theoretical predictions. This approach puts theory to work and overcomes the limits of identification in natural experiments. To this end, RDRECON will further our understanding of how households respond to personal and market experiences, and provide helpful insights for policy makers.
Summary
Households are exposed to a wide array of monetary and non-monetary risks: employment risk, financial risk, interest rate risk, and health and mortality risk, to name a few. Society and policymakers can certainly help households manage risk, but to be effective, they need to understand the ways households cope with risk and how vulnerable they are to market and policy changes. For instance, how do households react to bank defaults and market failures? How personal do these experiences have to be for households to change behavior? And how permanent are the changes in behavior?
The goal of the proposed research program is to understand how personal and market experiences affect financial decisions made by households, such as savings behavior, portfolio allocation, borrowing decisions, mortgage choices, and pension savings. RDRECON combines theory and evidence with an empirical research strategy that is comprised of both natural and field experiments. The theoretical component models how households make decisions. The empirical component uses both econometric and experimental methodologies to study actual household behavior across a range of economic and financial margins, as well as the influence of personal and market experiences on a household’s financial choices.
RDRECON’s strength and path-breaking innovation is its combination of administrative register data and controlled field experiments to form treatment and control groups of interest which allow empirical identification of theoretical predictions. This approach puts theory to work and overcomes the limits of identification in natural experiments. To this end, RDRECON will further our understanding of how households respond to personal and market experiences, and provide helpful insights for policy makers.
Max ERC Funding
1 461 881 €
Duration
Start date: 2015-05-01, End date: 2020-04-30
