Project acronym aCROBAT
Project Circadian Regulation Of Brown Adipose Thermogenesis
Researcher (PI) Zachary Philip Gerhart-Hines
Host Institution (HI) KOBENHAVNS UNIVERSITET
Call Details Starting Grant (StG), LS4, ERC-2014-STG
Summary Obesity and diabetes have reached pandemic proportions and new therapeutic strategies are critically needed. Brown adipose tissue (BAT), a major source of heat production, possesses significant energy-dissipating capacity and therefore represents a promising target to use in combating these diseases. Recently, I discovered a novel link between circadian rhythm and thermogenic stress in the control of the conserved, calorie-burning functions of BAT. Circadian and thermogenic signaling to BAT incorporates blood-borne hormonal and nutrient cues with direct neuronal input. Yet how these responses coordinately shape BAT energy-expending potential through the regulation of cell surface receptors, metabolic enzymes, and transcriptional effectors is still not understood. My primary goal is to investigate this previously unappreciated network of crosstalk that allows mammals to effectively orchestrate daily rhythms in BAT metabolism, while maintaining their ability to adapt to abrupt changes in energy demand. My group will address this question using gain and loss-of-function in vitro and in vivo studies, newly-generated mouse models, customized physiological phenotyping, and cutting-edge advances in next generation RNA sequencing and mass spectrometry. Preliminary, small-scale validations of our methodologies have already yielded a number of novel candidates that may drive key facets of BAT metabolism. Additionally, we will extend our circadian and thermogenic studies into humans to evaluate the translational potential. Our results will advance the fundamental understanding of how daily oscillations in bioenergetic networks establish a framework for the anticipation of and adaptation to environmental challenges. Importantly, we expect that these mechanistic insights will reveal pharmacological targets through which we can unlock evolutionary constraints and harness the energy-expending potential of BAT for the prevention and treatment of obesity and diabetes.
Summary
Obesity and diabetes have reached pandemic proportions and new therapeutic strategies are critically needed. Brown adipose tissue (BAT), a major source of heat production, possesses significant energy-dissipating capacity and therefore represents a promising target to use in combating these diseases. Recently, I discovered a novel link between circadian rhythm and thermogenic stress in the control of the conserved, calorie-burning functions of BAT. Circadian and thermogenic signaling to BAT incorporates blood-borne hormonal and nutrient cues with direct neuronal input. Yet how these responses coordinately shape BAT energy-expending potential through the regulation of cell surface receptors, metabolic enzymes, and transcriptional effectors is still not understood. My primary goal is to investigate this previously unappreciated network of crosstalk that allows mammals to effectively orchestrate daily rhythms in BAT metabolism, while maintaining their ability to adapt to abrupt changes in energy demand. My group will address this question using gain and loss-of-function in vitro and in vivo studies, newly-generated mouse models, customized physiological phenotyping, and cutting-edge advances in next generation RNA sequencing and mass spectrometry. Preliminary, small-scale validations of our methodologies have already yielded a number of novel candidates that may drive key facets of BAT metabolism. Additionally, we will extend our circadian and thermogenic studies into humans to evaluate the translational potential. Our results will advance the fundamental understanding of how daily oscillations in bioenergetic networks establish a framework for the anticipation of and adaptation to environmental challenges. Importantly, we expect that these mechanistic insights will reveal pharmacological targets through which we can unlock evolutionary constraints and harness the energy-expending potential of BAT for the prevention and treatment of obesity and diabetes.
Max ERC Funding
1 497 008 €
Duration
Start date: 2015-05-01, End date: 2020-04-30
Project acronym RDRECON
Project Risky Decisions: Revealing Economic Behaviour
Researcher (PI) Steffen Andersen
Host Institution (HI) COPENHAGEN BUSINESS SCHOOL
Call Details Starting Grant (StG), SH1, ERC-2014-STG
Summary Households are exposed to a wide array of monetary and non-monetary risks: employment risk, financial risk, interest rate risk, and health and mortality risk, to name a few. Society and policymakers can certainly help households manage risk, but to be effective, they need to understand the ways households cope with risk and how vulnerable they are to market and policy changes. For instance, how do households react to bank defaults and market failures? How personal do these experiences have to be for households to change behavior? And how permanent are the changes in behavior?
The goal of the proposed research program is to understand how personal and market experiences affect financial decisions made by households, such as savings behavior, portfolio allocation, borrowing decisions, mortgage choices, and pension savings. RDRECON combines theory and evidence with an empirical research strategy that is comprised of both natural and field experiments. The theoretical component models how households make decisions. The empirical component uses both econometric and experimental methodologies to study actual household behavior across a range of economic and financial margins, as well as the influence of personal and market experiences on a household’s financial choices.
RDRECON’s strength and path-breaking innovation is its combination of administrative register data and controlled field experiments to form treatment and control groups of interest which allow empirical identification of theoretical predictions. This approach puts theory to work and overcomes the limits of identification in natural experiments. To this end, RDRECON will further our understanding of how households respond to personal and market experiences, and provide helpful insights for policy makers.
Summary
Households are exposed to a wide array of monetary and non-monetary risks: employment risk, financial risk, interest rate risk, and health and mortality risk, to name a few. Society and policymakers can certainly help households manage risk, but to be effective, they need to understand the ways households cope with risk and how vulnerable they are to market and policy changes. For instance, how do households react to bank defaults and market failures? How personal do these experiences have to be for households to change behavior? And how permanent are the changes in behavior?
The goal of the proposed research program is to understand how personal and market experiences affect financial decisions made by households, such as savings behavior, portfolio allocation, borrowing decisions, mortgage choices, and pension savings. RDRECON combines theory and evidence with an empirical research strategy that is comprised of both natural and field experiments. The theoretical component models how households make decisions. The empirical component uses both econometric and experimental methodologies to study actual household behavior across a range of economic and financial margins, as well as the influence of personal and market experiences on a household’s financial choices.
RDRECON’s strength and path-breaking innovation is its combination of administrative register data and controlled field experiments to form treatment and control groups of interest which allow empirical identification of theoretical predictions. This approach puts theory to work and overcomes the limits of identification in natural experiments. To this end, RDRECON will further our understanding of how households respond to personal and market experiences, and provide helpful insights for policy makers.
Max ERC Funding
1 461 881 €
Duration
Start date: 2015-05-01, End date: 2020-04-30
