Project acronym 2-HIT
Project Genetic interaction networks: From C. elegans to human disease
Researcher (PI) Ben Lehner
Host Institution (HI) FUNDACIO CENTRE DE REGULACIO GENOMICA
Country Spain
Call Details Starting Grant (StG), LS2, ERC-2007-StG
Summary Most hereditary diseases in humans are genetically complex, resulting from combinations of mutations in multiple genes. However synthetic interactions between genes are very difficult to identify in population studies because of a lack of statistical power and we fundamentally do not understand how mutations interact to produce phenotypes. C. elegans is a unique animal in which genetic interactions can be rapidly identified in vivo using RNA interference, and we recently used this system to construct the first genetic interaction network for any animal, focused on signal transduction genes. The first objective of this proposal is to extend this work and map a comprehensive genetic interaction network for this model metazoan. This project will provide the first insights into the global properties of animal genetic interaction networks, and a comprehensive view of the functional relationships between genes in an animal. The second objective of the proposal is to use C. elegans to develop and validate experimentally integrated gene networks that connect genes to phenotypes and predict genetic interactions on a genome-wide scale. The methods that we develop and validate in C. elegans will then be applied to predict phenotypes and interactions for human genes. The final objective is to dissect the molecular mechanisms underlying genetic interactions, and to understand how these interactions evolve. The combined aim of these three objectives is to generate a framework for understanding and predicting how mutations interact to produce phenotypes, including in human disease.
Summary
Most hereditary diseases in humans are genetically complex, resulting from combinations of mutations in multiple genes. However synthetic interactions between genes are very difficult to identify in population studies because of a lack of statistical power and we fundamentally do not understand how mutations interact to produce phenotypes. C. elegans is a unique animal in which genetic interactions can be rapidly identified in vivo using RNA interference, and we recently used this system to construct the first genetic interaction network for any animal, focused on signal transduction genes. The first objective of this proposal is to extend this work and map a comprehensive genetic interaction network for this model metazoan. This project will provide the first insights into the global properties of animal genetic interaction networks, and a comprehensive view of the functional relationships between genes in an animal. The second objective of the proposal is to use C. elegans to develop and validate experimentally integrated gene networks that connect genes to phenotypes and predict genetic interactions on a genome-wide scale. The methods that we develop and validate in C. elegans will then be applied to predict phenotypes and interactions for human genes. The final objective is to dissect the molecular mechanisms underlying genetic interactions, and to understand how these interactions evolve. The combined aim of these three objectives is to generate a framework for understanding and predicting how mutations interact to produce phenotypes, including in human disease.
Max ERC Funding
1 100 000 €
Duration
Start date: 2008-09-01, End date: 2014-04-30
Project acronym 2D-TOPSENSE
Project Tunable optoelectronic devices by strain engineering of 2D semiconductors
Researcher (PI) Andres CASTELLANOS
Host Institution (HI) AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Country Spain
Call Details Starting Grant (StG), PE7, ERC-2017-STG
Summary The goal of 2D-TOPSENSE is to exploit the remarkable stretchability of two-dimensional semiconductors to fabricate optoelectronic devices where strain is used as an external knob to tune their properties.
While bulk semiconductors tend to break under strains larger than 1.5%, 2D semiconductors (such as MoS2) can withstand deformations of up to 10-20% before rupture. This large breaking strength promises a great potential of 2D semiconductors as ‘straintronic’ materials, whose properties can be adjusted by applying a deformation to their lattice. In fact, recent theoretical works predicted an interesting physical phenomenon: a tensile strain-induced semiconductor-to-metal transition in 2D semiconductors. By tensioning single-layer MoS2 from 0% up to 10%, its electronic band structure is expected to undergo a continuous transition from a wide direct band-gap of 1.8 eV to a metallic behavior. This unprecedented large strain-tunability will undoubtedly have a strong impact in a wide range of optoelectronic applications such as photodetectors whose cut-off wavelength is tuned by varying the applied strain or atomically thin light modulators.
To date, experimental works on strain engineering have been mostly focused on fundamental studies, demonstrating part of the potential of 2D semiconductors in straintronics, but they have failed to exploit strain engineering to add extra functionalities to optoelectronic devices. In 2D-TOPSENSE I will go beyond the state of the art in straintronics by designing and fabricating optoelectronic devices whose properties and performance can be tuned by means of applying strain. 2D-TOPSENSE will focus on photodetectors with a tunable bandwidth and detectivity, light emitting devices whose emission wavelength can be adjusted, light modulators based on 2D semiconductors such as transition metal dichalcogenides or black phosphorus and solar funnels capable of directing the photogenerated charge carriers towards a specific position.
Summary
The goal of 2D-TOPSENSE is to exploit the remarkable stretchability of two-dimensional semiconductors to fabricate optoelectronic devices where strain is used as an external knob to tune their properties.
While bulk semiconductors tend to break under strains larger than 1.5%, 2D semiconductors (such as MoS2) can withstand deformations of up to 10-20% before rupture. This large breaking strength promises a great potential of 2D semiconductors as ‘straintronic’ materials, whose properties can be adjusted by applying a deformation to their lattice. In fact, recent theoretical works predicted an interesting physical phenomenon: a tensile strain-induced semiconductor-to-metal transition in 2D semiconductors. By tensioning single-layer MoS2 from 0% up to 10%, its electronic band structure is expected to undergo a continuous transition from a wide direct band-gap of 1.8 eV to a metallic behavior. This unprecedented large strain-tunability will undoubtedly have a strong impact in a wide range of optoelectronic applications such as photodetectors whose cut-off wavelength is tuned by varying the applied strain or atomically thin light modulators.
To date, experimental works on strain engineering have been mostly focused on fundamental studies, demonstrating part of the potential of 2D semiconductors in straintronics, but they have failed to exploit strain engineering to add extra functionalities to optoelectronic devices. In 2D-TOPSENSE I will go beyond the state of the art in straintronics by designing and fabricating optoelectronic devices whose properties and performance can be tuned by means of applying strain. 2D-TOPSENSE will focus on photodetectors with a tunable bandwidth and detectivity, light emitting devices whose emission wavelength can be adjusted, light modulators based on 2D semiconductors such as transition metal dichalcogenides or black phosphorus and solar funnels capable of directing the photogenerated charge carriers towards a specific position.
Max ERC Funding
1 930 437 €
Duration
Start date: 2018-03-01, End date: 2023-02-28
Project acronym 2DNANOPTICA
Project Nano-optics on flatland: from quantum nanotechnology to nano-bio-photonics
Researcher (PI) Pablo Alonso-Gonzalez
Host Institution (HI) UNIVERSIDAD DE OVIEDO
Country Spain
Call Details Starting Grant (StG), PE3, ERC-2016-STG
Summary Ubiquitous in nature, light-matter interactions are of fundamental importance in science and all optical technologies. Understanding and controlling them has been a long-pursued objective in modern physics. However, so far, related experiments have relied on traditional optical schemes where, owing to the classical diffraction limit, control of optical fields to length scales below the wavelength of light is prevented. Importantly, this limitation impedes to exploit the extraordinary fundamental and scaling potentials of nanoscience and nanotechnology. A solution to concentrate optical fields into sub-diffracting volumes is the excitation of surface polaritons –coupled excitations of photons and mobile/bound charges in metals/polar materials (plasmons/phonons)-. However, their initial promises have been hindered by either strong optical losses or lack of electrical control in metals, and difficulties to fabricate high optical quality nanostructures in polar materials.
With the advent of two-dimensional (2D) materials and their extraordinary optical properties, during the last 2-3 years the visualization of both low-loss and electrically tunable (active) plasmons in graphene and high optical quality phonons in monolayer and multilayer h-BN nanostructures have been demonstrated in the mid-infrared spectral range, thus introducing a very encouraging arena for scientifically ground-breaking discoveries in nano-optics. Inspired by these extraordinary prospects, this ERC project aims to make use of our knowledge and unique expertise in 2D nanoplasmonics, and the recent advances in nanophononics, to establish a technological platform that, including coherent sources, waveguides, routers, and efficient detectors, permits an unprecedented active control and manipulation (at room temperature) of light and light-matter interactions on the nanoscale, thus laying experimentally the foundations of a 2D nano-optics field.
Summary
Ubiquitous in nature, light-matter interactions are of fundamental importance in science and all optical technologies. Understanding and controlling them has been a long-pursued objective in modern physics. However, so far, related experiments have relied on traditional optical schemes where, owing to the classical diffraction limit, control of optical fields to length scales below the wavelength of light is prevented. Importantly, this limitation impedes to exploit the extraordinary fundamental and scaling potentials of nanoscience and nanotechnology. A solution to concentrate optical fields into sub-diffracting volumes is the excitation of surface polaritons –coupled excitations of photons and mobile/bound charges in metals/polar materials (plasmons/phonons)-. However, their initial promises have been hindered by either strong optical losses or lack of electrical control in metals, and difficulties to fabricate high optical quality nanostructures in polar materials.
With the advent of two-dimensional (2D) materials and their extraordinary optical properties, during the last 2-3 years the visualization of both low-loss and electrically tunable (active) plasmons in graphene and high optical quality phonons in monolayer and multilayer h-BN nanostructures have been demonstrated in the mid-infrared spectral range, thus introducing a very encouraging arena for scientifically ground-breaking discoveries in nano-optics. Inspired by these extraordinary prospects, this ERC project aims to make use of our knowledge and unique expertise in 2D nanoplasmonics, and the recent advances in nanophononics, to establish a technological platform that, including coherent sources, waveguides, routers, and efficient detectors, permits an unprecedented active control and manipulation (at room temperature) of light and light-matter interactions on the nanoscale, thus laying experimentally the foundations of a 2D nano-optics field.
Max ERC Funding
1 459 219 €
Duration
Start date: 2017-01-01, End date: 2021-12-31
Project acronym 2DTHERMS
Project Design of new thermoelectric devices based on layered and field modulated nanostructures of strongly correlated electron systems
Researcher (PI) Jose Francisco Rivadulla Fernandez
Host Institution (HI) UNIVERSIDAD DE SANTIAGO DE COMPOSTELA
Country Spain
Call Details Starting Grant (StG), PE3, ERC-2010-StG_20091028
Summary Design of new thermoelectric devices based on layered and field modulated nanostructures of strongly correlated electron systems
Summary
Design of new thermoelectric devices based on layered and field modulated nanostructures of strongly correlated electron systems
Max ERC Funding
1 427 190 €
Duration
Start date: 2010-11-01, End date: 2015-10-31
Project acronym 4SUNS
Project 4-Colours/2-Junctions of III-V semiconductors on Si to use in electronics devices and solar cells
Researcher (PI) MarIa Nair LOPEZ MARTINEZ
Host Institution (HI) UNIVERSIDAD AUTONOMA DE MADRID
Country Spain
Call Details Starting Grant (StG), PE7, ERC-2017-STG
Summary It was early predicted by M. Green and coeval colleagues that dividing the solar spectrum into narrow ranges of colours is the most efficient manner to convert solar energy into electrical power. Multijunction solar cells are the current solution to this challenge, which have reached over 30% conversion efficiencies by stacking 3 junctions together. However, the large fabrication costs and time hinders their use in everyday life. It has been shown that highly mismatched alloy (HMA) materials provide a powerful playground to achieve at least 3 different colour absorption regions that enable optimised energy conversion with just one junction. Combining HMA-based junctions with standard Silicon solar cells will rocket solar conversion efficiency at a reduced price. To turn this ambition into marketable devices, several efforts are still needed and few challenges must be overcome.
4SUNS is a revolutionary approach for the development of HMA materials on Silicon technology, which will bring highly efficient multi-colour solar cells costs below current multijunction devices. The project will develop the technology of HMA materials on Silicon via material synthesis opening a new technology for the future. The understanding and optimization of highly mismatched alloy materials-using GaAsNP alloy- will provide building blocks for the fabrication of laboratory-size 4-colours/2-junctions solar cells.
Using a molecular beam epitaxy system, 4SUNS will grow 4-colours/2-junctions structure as well as it will manufacture the final devices. Structural and optoelectronic characterizations will carry out to determine the quality of the materials and the solar cells characteristic to obtain a competitive product. These new solar cells are competitive products to breakthrough on the solar energy sector solar cells and allowing Europe to take leadership on high efficiency solar cells.
Summary
It was early predicted by M. Green and coeval colleagues that dividing the solar spectrum into narrow ranges of colours is the most efficient manner to convert solar energy into electrical power. Multijunction solar cells are the current solution to this challenge, which have reached over 30% conversion efficiencies by stacking 3 junctions together. However, the large fabrication costs and time hinders their use in everyday life. It has been shown that highly mismatched alloy (HMA) materials provide a powerful playground to achieve at least 3 different colour absorption regions that enable optimised energy conversion with just one junction. Combining HMA-based junctions with standard Silicon solar cells will rocket solar conversion efficiency at a reduced price. To turn this ambition into marketable devices, several efforts are still needed and few challenges must be overcome.
4SUNS is a revolutionary approach for the development of HMA materials on Silicon technology, which will bring highly efficient multi-colour solar cells costs below current multijunction devices. The project will develop the technology of HMA materials on Silicon via material synthesis opening a new technology for the future. The understanding and optimization of highly mismatched alloy materials-using GaAsNP alloy- will provide building blocks for the fabrication of laboratory-size 4-colours/2-junctions solar cells.
Using a molecular beam epitaxy system, 4SUNS will grow 4-colours/2-junctions structure as well as it will manufacture the final devices. Structural and optoelectronic characterizations will carry out to determine the quality of the materials and the solar cells characteristic to obtain a competitive product. These new solar cells are competitive products to breakthrough on the solar energy sector solar cells and allowing Europe to take leadership on high efficiency solar cells.
Max ERC Funding
1 499 719 €
Duration
Start date: 2018-02-01, End date: 2023-01-31
Project acronym AMORE
Project A distributional MOdel of Reference to Entities
Researcher (PI) Gemma BOLEDA TORRENT
Host Institution (HI) UNIVERSIDAD POMPEU FABRA
Country Spain
Call Details Starting Grant (StG), SH4, ERC-2016-STG
Summary "When I asked my seven-year-old daughter ""Who is the boy in your class who was also new in school last year, like you?"", she instantly replied ""Daniel"", using the descriptive content in my utterance to identify an entity in the real world and refer to it. The ability to use language to refer to reality is crucial for humans, and yet it is very difficult to model. AMORE breaks new ground in Computational Linguistics, Linguistics, and Artificial Intelligence by developing a model of linguistic reference to entities implemented as a computational system that can learn its own representations from data.
This interdisciplinary project builds on two complementary semantic traditions: 1) Formal semantics, a symbolic approach that can delimit and track linguistic referents, but does not adequately match them with the descriptive content of linguistic expressions; 2) Distributional semantics, which can handle descriptive content but does not associate it to individuated referents. AMORE synthesizes the two approaches into a unified, scalable model of reference that operates with individuated referents and links them to referential expressions characterized by rich descriptive content. The model is a distributed (neural network) version of a formal semantic framework that is furthermore able to integrate perceptual (visual) and linguistic information about entities. We test it extensively in referential tasks that require matching noun phrases (“the Medicine student”, “the white cat”) with entity representations extracted from text and images.
AMORE advances our scientific understanding of language and its computational modeling, and contributes to the far-reaching debate between symbolic and distributed approaches to cognition with an integrative proposal. I am in a privileged position to carry out this integration, since I have contributed top research in both distributional and formal semantics.
"
Summary
"When I asked my seven-year-old daughter ""Who is the boy in your class who was also new in school last year, like you?"", she instantly replied ""Daniel"", using the descriptive content in my utterance to identify an entity in the real world and refer to it. The ability to use language to refer to reality is crucial for humans, and yet it is very difficult to model. AMORE breaks new ground in Computational Linguistics, Linguistics, and Artificial Intelligence by developing a model of linguistic reference to entities implemented as a computational system that can learn its own representations from data.
This interdisciplinary project builds on two complementary semantic traditions: 1) Formal semantics, a symbolic approach that can delimit and track linguistic referents, but does not adequately match them with the descriptive content of linguistic expressions; 2) Distributional semantics, which can handle descriptive content but does not associate it to individuated referents. AMORE synthesizes the two approaches into a unified, scalable model of reference that operates with individuated referents and links them to referential expressions characterized by rich descriptive content. The model is a distributed (neural network) version of a formal semantic framework that is furthermore able to integrate perceptual (visual) and linguistic information about entities. We test it extensively in referential tasks that require matching noun phrases (“the Medicine student”, “the white cat”) with entity representations extracted from text and images.
AMORE advances our scientific understanding of language and its computational modeling, and contributes to the far-reaching debate between symbolic and distributed approaches to cognition with an integrative proposal. I am in a privileged position to carry out this integration, since I have contributed top research in both distributional and formal semantics.
"
Max ERC Funding
1 499 805 €
Duration
Start date: 2017-02-01, End date: 2022-01-31
Project acronym ANIMETRICS
Project Measurement-Based Modeling and Animation of Complex Mechanical Phenomena
Researcher (PI) Miguel Angel Otaduy Tristan
Host Institution (HI) UNIVERSIDAD REY JUAN CARLOS
Country Spain
Call Details Starting Grant (StG), PE6, ERC-2011-StG_20101014
Summary Computer animation has traditionally been associated with applications in virtual-reality-based training, video games or feature films. However, interactive animation is gaining relevance in a more general scope, as a tool for early-stage analysis, design and planning in many applications in science and engineering. The user can get quick and visual feedback of the results, and then proceed by refining the experiments or designs. Potential applications include nanodesign, e-commerce or tactile telecommunication, but they also reach as far as, e.g., the analysis of ecological, climate, biological or physiological processes.
The application of computer animation is extremely limited in comparison to its potential outreach due to a trade-off between accuracy and computational efficiency. Such trade-off is induced by inherent complexity sources such as nonlinear or anisotropic behaviors, heterogeneous properties, or high dynamic ranges of effects.
The Animetrics project proposes a modeling and animation methodology, which consists of a multi-scale decomposition of complex processes, the description of the process at each scale through combination of simple local models, and fitting the parameters of those local models using large amounts of data from example effects. The modeling and animation methodology will be explored on specific problems arising in complex mechanical phenomena, including viscoelasticity of solids and thin shells, multi-body contact, granular and liquid flow, and fracture of solids.
Summary
Computer animation has traditionally been associated with applications in virtual-reality-based training, video games or feature films. However, interactive animation is gaining relevance in a more general scope, as a tool for early-stage analysis, design and planning in many applications in science and engineering. The user can get quick and visual feedback of the results, and then proceed by refining the experiments or designs. Potential applications include nanodesign, e-commerce or tactile telecommunication, but they also reach as far as, e.g., the analysis of ecological, climate, biological or physiological processes.
The application of computer animation is extremely limited in comparison to its potential outreach due to a trade-off between accuracy and computational efficiency. Such trade-off is induced by inherent complexity sources such as nonlinear or anisotropic behaviors, heterogeneous properties, or high dynamic ranges of effects.
The Animetrics project proposes a modeling and animation methodology, which consists of a multi-scale decomposition of complex processes, the description of the process at each scale through combination of simple local models, and fitting the parameters of those local models using large amounts of data from example effects. The modeling and animation methodology will be explored on specific problems arising in complex mechanical phenomena, including viscoelasticity of solids and thin shells, multi-body contact, granular and liquid flow, and fracture of solids.
Max ERC Funding
1 277 969 €
Duration
Start date: 2012-01-01, End date: 2016-12-31
Project acronym ARCTIC
Project Air Transport as Information and Computation
Researcher (PI) Massimiliano ZANIN
Host Institution (HI) AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Country Spain
Call Details Starting Grant (StG), SH2, ERC-2019-STG
Summary Air transport has by and large been studied as a transportation process, in which different elements, e.g. aircraft or passengers, move within the system. While intuitive, this approach entails several drawbacks, including the need for large-scale simulations, the reliance on real data, and the difficulty of extracting macro-scale conclusions from large quantities of micro- scale results. The lack of a better approach is in part responsible for our inability to fully understand delay propagation, one of the most important phenomena in air transport. ARCTIC proposes an ambitious program to change the conceptual framework used to analyse air transport, inspired by the way the brain is studied in neuroscience. It is based on understanding air transport as an information processing system, in which the movement of aircraft is merely a vehicle for information transfer. Airports then become computational units, receiving information from their neighbours through inbound flights under the form of delays; processing it in a potentially non-linear way; and redistributing the result to the system as outbound delays. In this proposal I show how, as already common in neuroscience, such computation can be made explicit by using a combination of information sciences and statistical physics techniques: from the detection of information movements through causality metrics, up to the representation of the resulting transfer structures through complex networks and their topological properties. The approach also entails important challenges, e.g. the definition of appropriate metrics or the translation of the obtained insights into implementable policies. In the main text of the proposal I present a number of preliminary results that point towards a radically new way of thinking about the dynamics of air transport. ARCTIC’s methodology will be used over the next five years to characterize and model delay propagation, as well as to limit its societal and economic impact.
Summary
Air transport has by and large been studied as a transportation process, in which different elements, e.g. aircraft or passengers, move within the system. While intuitive, this approach entails several drawbacks, including the need for large-scale simulations, the reliance on real data, and the difficulty of extracting macro-scale conclusions from large quantities of micro- scale results. The lack of a better approach is in part responsible for our inability to fully understand delay propagation, one of the most important phenomena in air transport. ARCTIC proposes an ambitious program to change the conceptual framework used to analyse air transport, inspired by the way the brain is studied in neuroscience. It is based on understanding air transport as an information processing system, in which the movement of aircraft is merely a vehicle for information transfer. Airports then become computational units, receiving information from their neighbours through inbound flights under the form of delays; processing it in a potentially non-linear way; and redistributing the result to the system as outbound delays. In this proposal I show how, as already common in neuroscience, such computation can be made explicit by using a combination of information sciences and statistical physics techniques: from the detection of information movements through causality metrics, up to the representation of the resulting transfer structures through complex networks and their topological properties. The approach also entails important challenges, e.g. the definition of appropriate metrics or the translation of the obtained insights into implementable policies. In the main text of the proposal I present a number of preliminary results that point towards a radically new way of thinking about the dynamics of air transport. ARCTIC’s methodology will be used over the next five years to characterize and model delay propagation, as well as to limit its societal and economic impact.
Max ERC Funding
1 297 024 €
Duration
Start date: 2020-03-01, End date: 2025-02-28
Project acronym BacBio
Project Mechanistic and functional studies of Bacillus biofilms assembly on plants, and their impact in sustainable agriculture and food safety
Researcher (PI) Diego Francisco Romero Hinojosa
Host Institution (HI) UNIVERSIDAD DE MALAGA
Country Spain
Call Details Starting Grant (StG), LS9, ERC-2014-STG
Summary Sustainable agriculture is an ambitious concept conceived to improve productivity but minimizing side effects. Why the efficiency of a biocontrol agent is so variable? How can different therapies be efficiently exploited in a combined way to combat microbial diseases? These are questions that need investigation to convey with criteria of sustainability. What I present is an integral proposal aim to study the microbial ecology and specifically bacterial biofilms as a central axis of two differential but likely interconnected scenarios in plant health: i) the beneficial interaction of the biocontrol agent (BCA) Bacillus subtilis, and ii) the non-conventional interaction of the food-borne pathogen Bacillus cereus.
I will start working with B. subtilis, and reasons are: 1) Different isolates are promising BCAs and are commercialized for such purpose, 2) There exist vast information of the genetics circuitries that govern important aspects of B. subtilis physiology as antibiotic production, cell differentiation, and biofilm formation. In parallel I propose to study the way B. cereus, a food-borne pathogenic bacterium interacts with vegetables. I am planning to set up a multidisciplinary approach that will combine genetics, biochemistry, proteomics, cell biology and molecular biology to visualize how these bacterial population interacts, communicates with plants and other microorganisms, or how all these factors trigger or inhibit the developmental program ending in biofilm formation. I am also interested on knowing if structural components of the bacterial extracellular matrix (exopolysaccharides or amyloid proteins) are important for bacterial fitness. If this were the case, I will also investigate which external factors affect their expression and assembly in functional biofilms. The insights get on these studies are committed to impulse our knowledge on microbial ecology and their biotechnological applicability to sustainable agriculture and food safety.
Summary
Sustainable agriculture is an ambitious concept conceived to improve productivity but minimizing side effects. Why the efficiency of a biocontrol agent is so variable? How can different therapies be efficiently exploited in a combined way to combat microbial diseases? These are questions that need investigation to convey with criteria of sustainability. What I present is an integral proposal aim to study the microbial ecology and specifically bacterial biofilms as a central axis of two differential but likely interconnected scenarios in plant health: i) the beneficial interaction of the biocontrol agent (BCA) Bacillus subtilis, and ii) the non-conventional interaction of the food-borne pathogen Bacillus cereus.
I will start working with B. subtilis, and reasons are: 1) Different isolates are promising BCAs and are commercialized for such purpose, 2) There exist vast information of the genetics circuitries that govern important aspects of B. subtilis physiology as antibiotic production, cell differentiation, and biofilm formation. In parallel I propose to study the way B. cereus, a food-borne pathogenic bacterium interacts with vegetables. I am planning to set up a multidisciplinary approach that will combine genetics, biochemistry, proteomics, cell biology and molecular biology to visualize how these bacterial population interacts, communicates with plants and other microorganisms, or how all these factors trigger or inhibit the developmental program ending in biofilm formation. I am also interested on knowing if structural components of the bacterial extracellular matrix (exopolysaccharides or amyloid proteins) are important for bacterial fitness. If this were the case, I will also investigate which external factors affect their expression and assembly in functional biofilms. The insights get on these studies are committed to impulse our knowledge on microbial ecology and their biotechnological applicability to sustainable agriculture and food safety.
Max ERC Funding
1 453 563 €
Duration
Start date: 2015-03-01, End date: 2021-02-28
Project acronym BAR2LEGAB
Project Women travelling to seek abortion care in Europe: the impact of barriers to legal abortion on women living in countries with ostensibly liberal abortion laws
Researcher (PI) Silvia De Zordo
Host Institution (HI) UNIVERSITAT DE BARCELONA
Country Spain
Call Details Starting Grant (StG), SH2, ERC-2015-STG
Summary In many European countries with ostensibly liberal abortion laws, women face legal restrictions to abortion beyond the first trimester of pregnancy, as well as other barriers to legal abortion, in particular shortages of providers willing and able to offer abortion due to poor training and to conscientious objection among physicians. The Council of Europe has recognized that conscientious objection can make access to safe abortion more difficult or impossible, particularly in rural areas and for low income women, who are forced to travel far to seek abortion care, including abroad. The WHO also highlights that delaying abortion care increases risks for women’s reproductive health. Despite the relevance of this topic from a public health and human rights perspective, the impact of procedural and social barriers to legal abortion on women in countries with ostensibly liberal abortion laws has not been studied by social scientists in Europe. This five-year research project is envisaged as a ground-breaking multi-disciplinary, mixed-methods investigation that will fill this gap, by capitalizing on previous, pioneer anthropological research of the PI on abortion and conscientious objection. It will contribute to the anthropology of reproduction in Europe, and particularly to the existing literature on abortion, conscientious objection and the medicalization of reproduction, and to the international debate on gender inequalities and citizenship, by exploring how barriers to legal abortion are constructed and how women embody and challenge them in different countries, by travelling or seeking illegal abortion, as well as their conceptualizations of abortion and their self perception as moral/political subjects. The project will be carried out in France, Italy and Spain, where the few existing studies show that women face several barriers to legal abortion as well as in the UK, the Netherlands and Spain, where Italian and French women travel to seek abortion care.
Summary
In many European countries with ostensibly liberal abortion laws, women face legal restrictions to abortion beyond the first trimester of pregnancy, as well as other barriers to legal abortion, in particular shortages of providers willing and able to offer abortion due to poor training and to conscientious objection among physicians. The Council of Europe has recognized that conscientious objection can make access to safe abortion more difficult or impossible, particularly in rural areas and for low income women, who are forced to travel far to seek abortion care, including abroad. The WHO also highlights that delaying abortion care increases risks for women’s reproductive health. Despite the relevance of this topic from a public health and human rights perspective, the impact of procedural and social barriers to legal abortion on women in countries with ostensibly liberal abortion laws has not been studied by social scientists in Europe. This five-year research project is envisaged as a ground-breaking multi-disciplinary, mixed-methods investigation that will fill this gap, by capitalizing on previous, pioneer anthropological research of the PI on abortion and conscientious objection. It will contribute to the anthropology of reproduction in Europe, and particularly to the existing literature on abortion, conscientious objection and the medicalization of reproduction, and to the international debate on gender inequalities and citizenship, by exploring how barriers to legal abortion are constructed and how women embody and challenge them in different countries, by travelling or seeking illegal abortion, as well as their conceptualizations of abortion and their self perception as moral/political subjects. The project will be carried out in France, Italy and Spain, where the few existing studies show that women face several barriers to legal abortion as well as in the UK, the Netherlands and Spain, where Italian and French women travel to seek abortion care.
Max ERC Funding
1 495 753 €
Duration
Start date: 2016-10-01, End date: 2021-12-31
Project acronym BETTERSENSE
Project Nanodevice Engineering for a Better Chemical Gas Sensing Technology
Researcher (PI) Juan Daniel Prades Garcia
Host Institution (HI) UNIVERSITAT DE BARCELONA
Country Spain
Call Details Starting Grant (StG), PE7, ERC-2013-StG
Summary BetterSense aims to solve the two main problems in current gas sensor technologies: the high power consumption and the poor selectivity. For the former, we propose a radically new approach: to integrate the sensing components and the energy sources intimately, at the nanoscale, in order to achieve a new kind of sensor concept featuring zero power consumption. For the latter, we will mimic the biological receptors designing a kit of gas-specific molecular organic functionalizations to reach ultra-high gas selectivity figures, comparable to those of biological processes. Both cutting-edge concepts will be developed in parallel an integrated together to render a totally new gas sensing technology that surpasses the state-of-the-art.
As a matter of fact, the project will enable, for the first time, the integration of gas detectors in energetically autonomous sensors networks. Additionally, BetterSense will provide an integral solution to the gas sensing challenge by producing a full set of gas-specific sensors over the same platform to ease their integration in multi-analyte systems. Moreover, the project approach will certainly open opportunities in adjacent fields in which power consumption, specificity and nano/micro integration are a concern, such as liquid chemical and biological sensing.
In spite of the promising evidences that demonstrate the feasibility of this proposal, there are still many scientific and technological issues to solve, most of them in the edge of what is known and what is possible today in nano-fabrication and nano/micro integration. For this reason, BetterSense also aims to contribute to the global challenge of making nanodevices compatible with scalable, cost-effective, microelectronic technologies.
For all this, addressing this challenging proposal in full requires a funding scheme compatible with a high-risk/high-gain vision to finance the full dedication of a highly motivated research team with multidisciplinary skill
Summary
BetterSense aims to solve the two main problems in current gas sensor technologies: the high power consumption and the poor selectivity. For the former, we propose a radically new approach: to integrate the sensing components and the energy sources intimately, at the nanoscale, in order to achieve a new kind of sensor concept featuring zero power consumption. For the latter, we will mimic the biological receptors designing a kit of gas-specific molecular organic functionalizations to reach ultra-high gas selectivity figures, comparable to those of biological processes. Both cutting-edge concepts will be developed in parallel an integrated together to render a totally new gas sensing technology that surpasses the state-of-the-art.
As a matter of fact, the project will enable, for the first time, the integration of gas detectors in energetically autonomous sensors networks. Additionally, BetterSense will provide an integral solution to the gas sensing challenge by producing a full set of gas-specific sensors over the same platform to ease their integration in multi-analyte systems. Moreover, the project approach will certainly open opportunities in adjacent fields in which power consumption, specificity and nano/micro integration are a concern, such as liquid chemical and biological sensing.
In spite of the promising evidences that demonstrate the feasibility of this proposal, there are still many scientific and technological issues to solve, most of them in the edge of what is known and what is possible today in nano-fabrication and nano/micro integration. For this reason, BetterSense also aims to contribute to the global challenge of making nanodevices compatible with scalable, cost-effective, microelectronic technologies.
For all this, addressing this challenging proposal in full requires a funding scheme compatible with a high-risk/high-gain vision to finance the full dedication of a highly motivated research team with multidisciplinary skill
Max ERC Funding
1 498 452 €
Duration
Start date: 2014-02-01, End date: 2019-01-31
Project acronym BIOCON
Project Biological origins of linguistic constraints
Researcher (PI) Juan Manuel Toro
Host Institution (HI) UNIVERSIDAD POMPEU FABRA
Country Spain
Call Details Starting Grant (StG), SH4, ERC-2012-StG_20111124
Summary The linguistic capacity to express and comprehend an unlimited number of ideas when combining a limited number of elements has only been observed in humans. Nevertheless, research has not fully identified the components of language that make it uniquely human and that allow infants to grasp the complexity of linguistic structure in an apparently effortless manner. Research on comparative cognition suggests humans and other species share powerful learning mechanisms and basic perceptual abilities we use for language processing. But humans display remarkable linguistic abilities that other animals do not possess. Understanding the interplay between general mechanisms shared across species and more specialized ones dedicated to the speech signal is at the heart of current debates in human language acquisition. This is a highly relevant issue for researchers in the fields of Psychology, Linguistics, Biology, Philosophy and Cognitive Neuroscience. By conducting experiments across several populations (human adults and infants) and species (human and nonhuman animals), and using a wide array of experimental techniques, the present proposal hopes to shed some light on the origins of shared biological constraints that guide more specialized mechanisms in the search for linguistic structure. More specifically, we hope to understand how general perceptual and cognitive mechanisms likely present in other animals constrain the way humans tackle the task of language acquisition. Our hypothesis is that differences between humans and other species are not the result of humans being able to process increasingly complex structures that are the hallmark of language. Rather, differences might be due to humans and other animals focusing on different cues present in the signal to extract relevant information. This research will hint at what is uniquely human and what is shared across different animals species.
Summary
The linguistic capacity to express and comprehend an unlimited number of ideas when combining a limited number of elements has only been observed in humans. Nevertheless, research has not fully identified the components of language that make it uniquely human and that allow infants to grasp the complexity of linguistic structure in an apparently effortless manner. Research on comparative cognition suggests humans and other species share powerful learning mechanisms and basic perceptual abilities we use for language processing. But humans display remarkable linguistic abilities that other animals do not possess. Understanding the interplay between general mechanisms shared across species and more specialized ones dedicated to the speech signal is at the heart of current debates in human language acquisition. This is a highly relevant issue for researchers in the fields of Psychology, Linguistics, Biology, Philosophy and Cognitive Neuroscience. By conducting experiments across several populations (human adults and infants) and species (human and nonhuman animals), and using a wide array of experimental techniques, the present proposal hopes to shed some light on the origins of shared biological constraints that guide more specialized mechanisms in the search for linguistic structure. More specifically, we hope to understand how general perceptual and cognitive mechanisms likely present in other animals constrain the way humans tackle the task of language acquisition. Our hypothesis is that differences between humans and other species are not the result of humans being able to process increasingly complex structures that are the hallmark of language. Rather, differences might be due to humans and other animals focusing on different cues present in the signal to extract relevant information. This research will hint at what is uniquely human and what is shared across different animals species.
Max ERC Funding
1 305 973 €
Duration
Start date: 2013-01-01, End date: 2018-12-31
Project acronym BioInspired_SolarH2
Project Engineering Bio-Inspired Systems for the Conversion of Solar Energy to Hydrogen
Researcher (PI) Elisabet ROMERO MESA
Host Institution (HI) FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA
Country Spain
Call Details Starting Grant (StG), PE3, ERC-2018-STG
Summary With this proposal, I aim to achieve the efficient conversion of solar energy to hydrogen. The overall objective is to engineer bio-inspired systems able to convert solar energy into a separation of charges and to construct devices by coupling these systems to catalysts in order to drive sustainable and effective water oxidation and hydrogen production.
The global energy crisis requires an urgent solution, we must replace fossil fuels for a renewable energy source: Solar energy. However, the efficient and inexpensive conversion and storage of solar energy into fuel remains a fundamental challenge. Currently, solar-energy conversion devices suffer from energy losses mainly caused by disorder in the materials used. The solution to this problem is to learn from nature. In photosynthesis, the photosystem II reaction centre (PSII RC) is a pigment-protein complex able to overcome disorder and convert solar photons into a separation of charges with near 100% efficiency. Crucially, the generated charges have enough potential to drive water oxidation and hydrogen production.
Previously, I have investigated the charge separation process in the PSII RC by a collection of spectroscopic techniques, which allowed me to formulate the design principles of photosynthetic charge separation, where coherence plays a crucial role. Here I will put these knowledge into action to design efficient and robust chromophore-protein assemblies for the collection and conversion of solar energy, employ organic chemistry and synthetic biology tools to construct these well defined and fully controllable assemblies, and apply a complete set of spectroscopic methods to investigate these engineered systems.
Following the approach Understand, Engineer, Implement, I will create a new generation of bio-inspired devices based on abundant and biodegradable materials that will drive the transformation of solar energy and water into hydrogen, an energy-rich molecule that can be stored and transported.
Summary
With this proposal, I aim to achieve the efficient conversion of solar energy to hydrogen. The overall objective is to engineer bio-inspired systems able to convert solar energy into a separation of charges and to construct devices by coupling these systems to catalysts in order to drive sustainable and effective water oxidation and hydrogen production.
The global energy crisis requires an urgent solution, we must replace fossil fuels for a renewable energy source: Solar energy. However, the efficient and inexpensive conversion and storage of solar energy into fuel remains a fundamental challenge. Currently, solar-energy conversion devices suffer from energy losses mainly caused by disorder in the materials used. The solution to this problem is to learn from nature. In photosynthesis, the photosystem II reaction centre (PSII RC) is a pigment-protein complex able to overcome disorder and convert solar photons into a separation of charges with near 100% efficiency. Crucially, the generated charges have enough potential to drive water oxidation and hydrogen production.
Previously, I have investigated the charge separation process in the PSII RC by a collection of spectroscopic techniques, which allowed me to formulate the design principles of photosynthetic charge separation, where coherence plays a crucial role. Here I will put these knowledge into action to design efficient and robust chromophore-protein assemblies for the collection and conversion of solar energy, employ organic chemistry and synthetic biology tools to construct these well defined and fully controllable assemblies, and apply a complete set of spectroscopic methods to investigate these engineered systems.
Following the approach Understand, Engineer, Implement, I will create a new generation of bio-inspired devices based on abundant and biodegradable materials that will drive the transformation of solar energy and water into hydrogen, an energy-rich molecule that can be stored and transported.
Max ERC Funding
1 500 000 €
Duration
Start date: 2019-04-01, End date: 2024-03-31
Project acronym BLOODCELLSCROSSTALK
Project The Crosstalk Between Red And White Blood Cells: The Case Of Fish
Researcher (PI) Maria del Mar Ortega-Villaizan Romo
Host Institution (HI) UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE
Country Spain
Call Details Starting Grant (StG), LS9, ERC-2014-STG
Summary Fish are the phylogenetically oldest vertebrate group with an immune system with clear similarities to the immune system of mammals. However, it is an actual matter of fact that the current knowledge of the fish immune system seems to lack the key piece to complete the puzzle.
In 1953 Nelson described a new role of human red blood cells (RBCs) which would go beyond the simple transport of O2 to the tissues. This new role, involved in the defence against microbes, described the antibody and complement-dependent binding of microbial immune complexes to RBCs. Regardless of the importance of this finding in the field of microbial infection, this phenomenon has been poorly evaluated. Just recently, a set of biological processes relevant to immunity have been described in the RBCs of a diverse group of organisms, which include: pathogen recognition, pathogen binding and clearance and cytokines production. Furthermore, it has been demonstrated that nucleated erythrocytes from fish and avian species develop specific responses to different pathogen associated molecular patterns and produce soluble factors that modulate leukocyte activity.
In the light of these pieces of evidences, and in an attempt to improve the knowledge of the immune mechanism(s) responsible for fish protection against viral infections, we raised the question: could nucleated fish erythrocytes be the key mediators of the antiviral responses? To answer this question we decided to focus our project on the evaluation of the crosstalk between red and white blood cells in the scenario of fish viral infections and prophylaxis. For that a working model composed of the rainbow trout and the viral haemorrhagic septicaemia virus (VHSV) was chosen, being the objectives of the project to evaluate: i) the implication trout RBCs (tRBCs) in the clearance of VHSV, and ii) the involvement of tRBCs in the blood transportation of the glycoprotein G of VHSV (GVHSV), the antigen encoded by the DNA vaccine.
Summary
Fish are the phylogenetically oldest vertebrate group with an immune system with clear similarities to the immune system of mammals. However, it is an actual matter of fact that the current knowledge of the fish immune system seems to lack the key piece to complete the puzzle.
In 1953 Nelson described a new role of human red blood cells (RBCs) which would go beyond the simple transport of O2 to the tissues. This new role, involved in the defence against microbes, described the antibody and complement-dependent binding of microbial immune complexes to RBCs. Regardless of the importance of this finding in the field of microbial infection, this phenomenon has been poorly evaluated. Just recently, a set of biological processes relevant to immunity have been described in the RBCs of a diverse group of organisms, which include: pathogen recognition, pathogen binding and clearance and cytokines production. Furthermore, it has been demonstrated that nucleated erythrocytes from fish and avian species develop specific responses to different pathogen associated molecular patterns and produce soluble factors that modulate leukocyte activity.
In the light of these pieces of evidences, and in an attempt to improve the knowledge of the immune mechanism(s) responsible for fish protection against viral infections, we raised the question: could nucleated fish erythrocytes be the key mediators of the antiviral responses? To answer this question we decided to focus our project on the evaluation of the crosstalk between red and white blood cells in the scenario of fish viral infections and prophylaxis. For that a working model composed of the rainbow trout and the viral haemorrhagic septicaemia virus (VHSV) was chosen, being the objectives of the project to evaluate: i) the implication trout RBCs (tRBCs) in the clearance of VHSV, and ii) the involvement of tRBCs in the blood transportation of the glycoprotein G of VHSV (GVHSV), the antigen encoded by the DNA vaccine.
Max ERC Funding
1 823 250 €
Duration
Start date: 2015-04-01, End date: 2020-10-31
Project acronym CAPA
Project Global existence and Computer-Assisted Proofs of singularities in incompressible fluids, with Applications
Researcher (PI) Javier GOMEZ-SERRANO
Host Institution (HI) UNIVERSITAT DE BARCELONA
Country Spain
Call Details Starting Grant (StG), PE1, ERC-2019-STG
Summary The goal of this proposal is twofold: on the one hand to pursue methods and ideas developed in recent work in the search for either singularities or global existence in incompressible fluids with finite energy and on the
other transfer the techniques to solve long-standing open problems in spectral geometry. A key ingredient in its success is to have accurate numerics together with a deep understanding of the regularity theory. Therefore, the interdisciplinary nature of this project, which involves numerical computations, computer-assisted proofs, modern PDE methods and harmonic analysis, is an essential ingredient for the successful outcome.
This proposal is divided in three blocks, the first two involving global existence and/or singularities for: the incompressible Euler and Navier-Stokes equations; the surface quasi-geostrophic (SQG), the generalized-SQG equations and related models; and a third one on applications to spectral geometry. There is a strong analogy between the SQG and the 3D Euler equations, and many results that hold for the former also hold for the latter.
A major theme is the interplay between rigorous computer calculations and traditional mathematics. Interval arithmetics are used as part of a proof whenever they are needed. As an evidence of its capabilities, I have pioneered techniques to show singularities in PDE related to fluid mechanics – even in low regularity settings –, developed a way to treat singular integrals, and solved eigenvalue problems using computer-assisted proofs. This is a completely novel approach that can be blended with more classical ones, resulting in very powerful theorems solving problems that can not be treated currently with pen and paper methods.
Summary
The goal of this proposal is twofold: on the one hand to pursue methods and ideas developed in recent work in the search for either singularities or global existence in incompressible fluids with finite energy and on the
other transfer the techniques to solve long-standing open problems in spectral geometry. A key ingredient in its success is to have accurate numerics together with a deep understanding of the regularity theory. Therefore, the interdisciplinary nature of this project, which involves numerical computations, computer-assisted proofs, modern PDE methods and harmonic analysis, is an essential ingredient for the successful outcome.
This proposal is divided in three blocks, the first two involving global existence and/or singularities for: the incompressible Euler and Navier-Stokes equations; the surface quasi-geostrophic (SQG), the generalized-SQG equations and related models; and a third one on applications to spectral geometry. There is a strong analogy between the SQG and the 3D Euler equations, and many results that hold for the former also hold for the latter.
A major theme is the interplay between rigorous computer calculations and traditional mathematics. Interval arithmetics are used as part of a proof whenever they are needed. As an evidence of its capabilities, I have pioneered techniques to show singularities in PDE related to fluid mechanics – even in low regularity settings –, developed a way to treat singular integrals, and solved eigenvalue problems using computer-assisted proofs. This is a completely novel approach that can be blended with more classical ones, resulting in very powerful theorems solving problems that can not be treated currently with pen and paper methods.
Max ERC Funding
1 483 073 €
Duration
Start date: 2020-07-01, End date: 2025-06-30
Project acronym CARBONLIGHT
Project Tunable light tightly bound to a single sheet of carbon atoms:
graphene as a novel platform for nano-optoelectronics
Researcher (PI) Frank Henricus Louis Koppens
Host Institution (HI) FUNDACIO INSTITUT DE CIENCIES FOTONIQUES
Country Spain
Call Details Starting Grant (StG), PE3, ERC-2012-StG_20111012
Summary Graphene, a one-atom-thick layer of carbon, has attracted enormous attention in diverse areas of applied and fundamental physics. Due to its unique crystal structure, charge carriers have an effective mass of zero and a very high mobility, even at room temperature. While graphene-based devices have an enormous potential for high-speed electronics, graphene has recently been recognized as a photonic material for novel optoelectronic applications.
Interestingly, graphene is also a promising host material for light that is confined to nanoscale dimensions, more than 100 times below the diffraction limit. Due to its ultra-small thickness and extremely high purity, graphene can support strongly confined propagating light fields coupled to the charge carriers in the material: surface plasmons. The properties of these plasmons are controllable by electrostatic gates, holding promise for in-situ tunability of light-matter interactions at a length scale far below the wavelength.
This project will experimentally investigate the new and virtually unexplored field of graphene surface plasmonics, and combine this with other appealing properties of graphene to demonstrate the unique potential of carbon-based nano-optoelectronics. The aim is to explore the limits of unprecedented light concentration, manipulation and detection at the nanoscale, to dramatically intensify nonlinear interactions between photons towards the quantum regime, and to reveal the subtle effects of cavity quantum electrodynamics on graphene-emitter systems. This research will reveal the far-reaching potential of a single sheet of carbon atoms as a host for light and electrons at the nanoscale, with prospects for novel nanoscale optical circuits and detectors, nano-optomechanical systems and tunable artificial quantum emitters.
Summary
Graphene, a one-atom-thick layer of carbon, has attracted enormous attention in diverse areas of applied and fundamental physics. Due to its unique crystal structure, charge carriers have an effective mass of zero and a very high mobility, even at room temperature. While graphene-based devices have an enormous potential for high-speed electronics, graphene has recently been recognized as a photonic material for novel optoelectronic applications.
Interestingly, graphene is also a promising host material for light that is confined to nanoscale dimensions, more than 100 times below the diffraction limit. Due to its ultra-small thickness and extremely high purity, graphene can support strongly confined propagating light fields coupled to the charge carriers in the material: surface plasmons. The properties of these plasmons are controllable by electrostatic gates, holding promise for in-situ tunability of light-matter interactions at a length scale far below the wavelength.
This project will experimentally investigate the new and virtually unexplored field of graphene surface plasmonics, and combine this with other appealing properties of graphene to demonstrate the unique potential of carbon-based nano-optoelectronics. The aim is to explore the limits of unprecedented light concentration, manipulation and detection at the nanoscale, to dramatically intensify nonlinear interactions between photons towards the quantum regime, and to reveal the subtle effects of cavity quantum electrodynamics on graphene-emitter systems. This research will reveal the far-reaching potential of a single sheet of carbon atoms as a host for light and electrons at the nanoscale, with prospects for novel nanoscale optical circuits and detectors, nano-optomechanical systems and tunable artificial quantum emitters.
Max ERC Funding
1 466 000 €
Duration
Start date: 2012-11-01, End date: 2017-10-31
Project acronym CARBONNEMS
Project NanoElectroMechanical Systems based on Carbon Nanotube and Graphene
Researcher (PI) Adrian Bachtold
Host Institution (HI) FUNDACIO INSTITUT DE CIENCIES FOTONIQUES
Country Spain
Call Details Starting Grant (StG), PE3, ERC-2011-StG_20101014
Summary Carbon nanotubes and graphene form a class of nanoscale objects with exceptional electrical, mechanical and structural properties. I propose to exploit these unique properties to fabricate and study various nanoelectromechanical systems (NEMS) based on graphene and nanotubes. Specifically, I will address two directions with major scientific interests:
1- I propose to study electromechanical resonators based on an individual nanotube or on a single layer of graphene. My group has a leading position in this recent research field and the idea is to take advantage of our expertise for two sets of experiments, one on inertial mass sensing and one on the exploration of quantum motion. These two topics are generating at present an intense activity in the NEMS community. Experiments are usually carried out using microfabricated silicon resonators but the ultra low mass of nanotubes and graphene has here an enormous asset. It drastically improves the sensitivity of mass sensing and it dramatically enhances the amplitude of the motion in the quantum regime.
2- My team will fabricate and exploit nanomotors based on nanotube and graphene. Only few man-made nanomotors have been demonstrated so far. Reasons are multiple. For instance, the fabrication of nanomotors is technically challenging. In addition, friction forces are often so strong that they hinder motion. Because of their unique properties, nanotubes and graphene represent a material of choice for the development of new nanomotors. We will construct nanomotors with different layouts and address how electrical, thermal or chemical energy can be transformed into mechanical energy in order to drive motion at the nanoscale.
Summary
Carbon nanotubes and graphene form a class of nanoscale objects with exceptional electrical, mechanical and structural properties. I propose to exploit these unique properties to fabricate and study various nanoelectromechanical systems (NEMS) based on graphene and nanotubes. Specifically, I will address two directions with major scientific interests:
1- I propose to study electromechanical resonators based on an individual nanotube or on a single layer of graphene. My group has a leading position in this recent research field and the idea is to take advantage of our expertise for two sets of experiments, one on inertial mass sensing and one on the exploration of quantum motion. These two topics are generating at present an intense activity in the NEMS community. Experiments are usually carried out using microfabricated silicon resonators but the ultra low mass of nanotubes and graphene has here an enormous asset. It drastically improves the sensitivity of mass sensing and it dramatically enhances the amplitude of the motion in the quantum regime.
2- My team will fabricate and exploit nanomotors based on nanotube and graphene. Only few man-made nanomotors have been demonstrated so far. Reasons are multiple. For instance, the fabrication of nanomotors is technically challenging. In addition, friction forces are often so strong that they hinder motion. Because of their unique properties, nanotubes and graphene represent a material of choice for the development of new nanomotors. We will construct nanomotors with different layouts and address how electrical, thermal or chemical energy can be transformed into mechanical energy in order to drive motion at the nanoscale.
Max ERC Funding
1 996 789 €
Duration
Start date: 2012-01-01, End date: 2016-12-31
Project acronym CDSIF
Project Contour dynamics and singularities in incompressible flows
Researcher (PI) Diego Cordoba
Host Institution (HI) AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Country Spain
Call Details Starting Grant (StG), PE1, ERC-2007-StG
Summary The search of singularities in incompressible flows has become a major challenge in the area of non-linear partial differential equations and is relevant in applied mathematics, physics and engineering. The existence of such singularities would have important consequences for the understanding of turbulence. One way to make progress in this direction, is to study plausible scenarios for the singularities supported by experiments or numerical analysis. With the more sophisticated numerical tools now available, the subject has recently gained considerable momentum. The main goal of this project is to study analytically several incompressible fluid models. In particular solutions that involve the possible formation of singularities or quasi-singular structures.
Summary
The search of singularities in incompressible flows has become a major challenge in the area of non-linear partial differential equations and is relevant in applied mathematics, physics and engineering. The existence of such singularities would have important consequences for the understanding of turbulence. One way to make progress in this direction, is to study plausible scenarios for the singularities supported by experiments or numerical analysis. With the more sophisticated numerical tools now available, the subject has recently gained considerable momentum. The main goal of this project is to study analytically several incompressible fluid models. In particular solutions that involve the possible formation of singularities or quasi-singular structures.
Max ERC Funding
650 000 €
Duration
Start date: 2008-09-01, End date: 2013-08-31
Project acronym CERCODE
Project Cerebellar control of Cortical Development
Researcher (PI) Juan Antonio Moreno Bravo
Host Institution (HI) AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Country Spain
Call Details Starting Grant (StG), LS5, ERC-2020-STG
Summary The cerebellum plays a critical role in motor function, but also in cognitive, and social behavioral development. It is proposed that the influence of the cerebellum in high-order processing is via modulatory effects on the cerebral cortex. Importantly, mounting evidences from clinical studies indicate that early cerebellar damage lead to wide range of changes in the structure and function of the developing cerebral cortex. This pathophysiological phenomenon is referred as “developmental diaschisis” and it suggests that the development of cerebral cortical areas is optimized by the guidance of cerebellar input. Thus, abnormalities in the developmental influence between these two brain regions might underlie the emergence of several neurodevelopmental disorders, such as autism spectrum disorders. Yet, the mechanisms by which the cerebellum is influencing the development and maturation of distant cortical circuits remain unknown.
Here, we will adopt a multidisciplinary and innovative approach to define the mechanisms by which the cerebellum influences the development of cortical areas. We hypothesize that these mechanisms are orchestrated by the thalamus, a key intermediate region connecting the cerebellum and the cortex. Therefore, a cerebellar malfunctioning might lead to alterations of cortical areas via thalamic reorganizations. Manipulating cerebellar early normal development and function offers us the possibility to shed light onto this issue. Thus, we will embryonically disturb the cerebello-thalamo-cortical output by anatomical, genetic and functional methods to determine the alterations in the development, organization, function and plasticity of the thalamocortical and cortical networks. The successful execution of this high-risk, high-impact research will provide insights on how the atypical cerebellar structure or function is involved in neurodevelopmental disorders.
Summary
The cerebellum plays a critical role in motor function, but also in cognitive, and social behavioral development. It is proposed that the influence of the cerebellum in high-order processing is via modulatory effects on the cerebral cortex. Importantly, mounting evidences from clinical studies indicate that early cerebellar damage lead to wide range of changes in the structure and function of the developing cerebral cortex. This pathophysiological phenomenon is referred as “developmental diaschisis” and it suggests that the development of cerebral cortical areas is optimized by the guidance of cerebellar input. Thus, abnormalities in the developmental influence between these two brain regions might underlie the emergence of several neurodevelopmental disorders, such as autism spectrum disorders. Yet, the mechanisms by which the cerebellum is influencing the development and maturation of distant cortical circuits remain unknown.
Here, we will adopt a multidisciplinary and innovative approach to define the mechanisms by which the cerebellum influences the development of cortical areas. We hypothesize that these mechanisms are orchestrated by the thalamus, a key intermediate region connecting the cerebellum and the cortex. Therefore, a cerebellar malfunctioning might lead to alterations of cortical areas via thalamic reorganizations. Manipulating cerebellar early normal development and function offers us the possibility to shed light onto this issue. Thus, we will embryonically disturb the cerebello-thalamo-cortical output by anatomical, genetic and functional methods to determine the alterations in the development, organization, function and plasticity of the thalamocortical and cortical networks. The successful execution of this high-risk, high-impact research will provide insights on how the atypical cerebellar structure or function is involved in neurodevelopmental disorders.
Max ERC Funding
1 499 709 €
Duration
Start date: 2021-01-01, End date: 2025-12-31
Project acronym CHAI
Project Cardiovascular Health effects of Air pollution in Andhra Pradesh, India
Researcher (PI) Cathryn Tonne
Host Institution (HI) FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA
Country Spain
Call Details Starting Grant (StG), LS7, ERC-2013-StG
Summary While there is convincing evidence that exposure to particulate air pollution causes cardiovascular mortality and morbidity, nearly all of this evidence is based on populations in high-income countries where concentrations are relatively low. There is large uncertainty regarding the relationship between combustion particles and cardiovascular risk for concentrations higher than outdoor concentrations in urban areas of high-income countries and lower than active smoking. Exposures for our study population are likely to be in this range.
We will investigate the cardiovascular health effects of exposure to particles from outdoor and household sources within a prospective cohort in Andhra Pradesh, India. Firstly, we will characterise exposure of participants using an integrated approach utilising outdoor mobile monitoring, personal monitoring, and questionnaire data. We will then collect data on participants’ activities and location using ‘life-logging’ from which activities driving exposure can be identified. Finally, we will quantify the association between exposure to particles and biomarkers of atherosclerosis.
This research will shed light on the relationship between particles and cardiovascular risk at concentration ranges where there is the largest uncertainty. It will provide some of the first evidence of the cardiovascular health effects of medium-term exposure to particulate air pollution outside of a high-income country. The research will also provide evidence regarding the relative contribution of sources and activities linked to high exposure, forming the basis of recommendations for exposure reduction.
Summary
While there is convincing evidence that exposure to particulate air pollution causes cardiovascular mortality and morbidity, nearly all of this evidence is based on populations in high-income countries where concentrations are relatively low. There is large uncertainty regarding the relationship between combustion particles and cardiovascular risk for concentrations higher than outdoor concentrations in urban areas of high-income countries and lower than active smoking. Exposures for our study population are likely to be in this range.
We will investigate the cardiovascular health effects of exposure to particles from outdoor and household sources within a prospective cohort in Andhra Pradesh, India. Firstly, we will characterise exposure of participants using an integrated approach utilising outdoor mobile monitoring, personal monitoring, and questionnaire data. We will then collect data on participants’ activities and location using ‘life-logging’ from which activities driving exposure can be identified. Finally, we will quantify the association between exposure to particles and biomarkers of atherosclerosis.
This research will shed light on the relationship between particles and cardiovascular risk at concentration ranges where there is the largest uncertainty. It will provide some of the first evidence of the cardiovascular health effects of medium-term exposure to particulate air pollution outside of a high-income country. The research will also provide evidence regarding the relative contribution of sources and activities linked to high exposure, forming the basis of recommendations for exposure reduction.
Max ERC Funding
1 200 000 €
Duration
Start date: 2015-01-01, End date: 2018-12-31