Project acronym COUNTATOMS
Project Counting Atoms in nanomaterials
Researcher (PI) Gustaaf Van Tendeloo
Host Institution (HI) UNIVERSITEIT ANTWERPEN
Country Belgium
Call Details Advanced Grant (AdG), PE5, ERC-2009-AdG
Summary COUNTING ATOMS IN NANOMATERIALS Advanced electron microscopy for solid state materials has evolved from a qualitative imaging setup to a quantitative scientific technique. This will allow us not only to probe and better understand the fundamental behaviour of (nano) materials at an atomic level but also to guide technology towards new horizons. The installation in 2009 of a new and unique electron microscope with a real space resolution of 50 pm and an energy resolution of 100 meV will make it possible to perform unique experiments. We believe that the position of atoms at an interface or at a surface can be determined with a precision of 1 pm; this precision is essential as input for modelling the materials properties. It will be first applied to explain the fascinating behaviour of multilayer ceramic materials. The new experimental limits will also allow us to literally count the number of atoms within an atomic columns; particularly counting the number of foreign atoms. This will not only require experimental skills, but also theoretical support. A real challenge is probing the magnetic and electronic information of a single atom column. According to theory this would be possible using ultra high resolution. This new probing technique will be of extreme importance for e.g. spintronics. Modern (nano) technology more and more requires information in 3 dimensions (3D), rather than in 2D. This is possible through electron tomography; this technique will be optimised in order to obtain sub nanometer precision. A final challenge is the study of the interface between soft matter (bio- or organic materials) and hard matter. This was hitherto impossible because of the radiation damage of the electron beam. With the possibility to lower the voltage to 80 kV and possibly 50 kV, maintaining more or less the resolution, we will hopefully be able to probe the active sites for catalysis.
Summary
COUNTING ATOMS IN NANOMATERIALS Advanced electron microscopy for solid state materials has evolved from a qualitative imaging setup to a quantitative scientific technique. This will allow us not only to probe and better understand the fundamental behaviour of (nano) materials at an atomic level but also to guide technology towards new horizons. The installation in 2009 of a new and unique electron microscope with a real space resolution of 50 pm and an energy resolution of 100 meV will make it possible to perform unique experiments. We believe that the position of atoms at an interface or at a surface can be determined with a precision of 1 pm; this precision is essential as input for modelling the materials properties. It will be first applied to explain the fascinating behaviour of multilayer ceramic materials. The new experimental limits will also allow us to literally count the number of atoms within an atomic columns; particularly counting the number of foreign atoms. This will not only require experimental skills, but also theoretical support. A real challenge is probing the magnetic and electronic information of a single atom column. According to theory this would be possible using ultra high resolution. This new probing technique will be of extreme importance for e.g. spintronics. Modern (nano) technology more and more requires information in 3 dimensions (3D), rather than in 2D. This is possible through electron tomography; this technique will be optimised in order to obtain sub nanometer precision. A final challenge is the study of the interface between soft matter (bio- or organic materials) and hard matter. This was hitherto impossible because of the radiation damage of the electron beam. With the possibility to lower the voltage to 80 kV and possibly 50 kV, maintaining more or less the resolution, we will hopefully be able to probe the active sites for catalysis.
Max ERC Funding
2 000 160 €
Duration
Start date: 2010-01-01, End date: 2014-12-31
Project acronym EATINGBODIES
Project The eating body in Western practice and theory
Researcher (PI) Anne-Marie Mol
Host Institution (HI) UNIVERSITEIT VAN AMSTERDAM
Country Netherlands
Call Details Advanced Grant (AdG), SH2, ERC-2009-AdG
Summary Human bodies eat. But what does this entail? The proposed project will explore how the eating body is shaped in different Western practices. These will include nutritional research and health care clinics, sites that have a far-reaching impact on how we eat. Four related sub-projects will trace the most relevant contrasts: (1) the eating body's health: limiting calorie intake versus maximising satisfaction; (2) the eating body's sensitivity: on tasting in various practices; (3) the eating body and other eaters: on different ways of relating individual and collective; (4) the eating body and its environment: on absorbing food, excreting waste and different bodily boundaries. These four sub-projects will together inform an anthropology of the eating body in Western practices. A fifth sub-project will attend to the eater in theory . Eating may be ubiquitous in practice, but it is strikingly absent from theorising in the Western philosophical tradition. This has profound implications for social science repertoires, which tend to include an actor modelled on the neuromuscular body. This actor sees, hears, moves and manipulates, but does not eat. Drawing on what we learn about the eating body in the empirical parts of the study, the fifth sub-project will model the actor on the eater. Eaters do not observe from a distance, but are mixed up with their surroundings. They do not judge impartially, but appreciate their food as they destroy it. Their metabolic activity, distributed over every cell, does not depend on central control. The theoretical possibilities that follow, will be experimentally explored. Thus the project aims to substantially enrich the Western tradition by feeding it with lessons drawn from its own marginalised experiences.
Summary
Human bodies eat. But what does this entail? The proposed project will explore how the eating body is shaped in different Western practices. These will include nutritional research and health care clinics, sites that have a far-reaching impact on how we eat. Four related sub-projects will trace the most relevant contrasts: (1) the eating body's health: limiting calorie intake versus maximising satisfaction; (2) the eating body's sensitivity: on tasting in various practices; (3) the eating body and other eaters: on different ways of relating individual and collective; (4) the eating body and its environment: on absorbing food, excreting waste and different bodily boundaries. These four sub-projects will together inform an anthropology of the eating body in Western practices. A fifth sub-project will attend to the eater in theory . Eating may be ubiquitous in practice, but it is strikingly absent from theorising in the Western philosophical tradition. This has profound implications for social science repertoires, which tend to include an actor modelled on the neuromuscular body. This actor sees, hears, moves and manipulates, but does not eat. Drawing on what we learn about the eating body in the empirical parts of the study, the fifth sub-project will model the actor on the eater. Eaters do not observe from a distance, but are mixed up with their surroundings. They do not judge impartially, but appreciate their food as they destroy it. Their metabolic activity, distributed over every cell, does not depend on central control. The theoretical possibilities that follow, will be experimentally explored. Thus the project aims to substantially enrich the Western tradition by feeding it with lessons drawn from its own marginalised experiences.
Max ERC Funding
1 848 701 €
Duration
Start date: 2010-03-01, End date: 2015-02-28
Project acronym ENTCHILD
Project The Entertainization of Childhood: An Etiology of Risks and Opportunities
Researcher (PI) Patricia Maria Valkenburg
Host Institution (HI) UNIVERSITEIT VAN AMSTERDAM
Country Netherlands
Call Details Advanced Grant (AdG), SH2, ERC-2009-AdG
Summary Never before has media entertainment been so abundantly accessible to children. In this project, I propose an entirely new theoretical model to understand entertainment processing and effects. The model enables us to simultaneously investigate: (a) how and why certain types of media entertainment may influence certain children, (b) which children are particularly susceptible to positive, which to negative, and which to both positive and negative entertainment effects, and (c) how children s social environment can maximize positive and minimize negative entertainment effects on children. The project involves a longitudinal panel study among 900 Dutch families. To measure the variables in the model, we will use some well-established survey instruments and neuropsychological tests. We will also employ two less conventional methods (coded media-use diaries and experience sampling methods) that may enhance serendipity in the development of our theory-advancing insights. We will use state-of-the art data-analytic techniques (e.g., multi-level and latent-growth curve modelling) to analyse the data. Although adventurous, this transdisciplinary project, the first in its kind, has great theoretical significance. If the assumptions of my model are supported, it may lead to a fundamental re-evaluation of earlier media-effects theories and research on children. The project will also have tremendous social relevance, not only for parents, but also for programme makers, educators, and the society as a whole. After all, only if we truly understand why, how, and which children are influenced by certain types of media entertainment, are we able to adequately target prevention and intervention strategies at these children.
Summary
Never before has media entertainment been so abundantly accessible to children. In this project, I propose an entirely new theoretical model to understand entertainment processing and effects. The model enables us to simultaneously investigate: (a) how and why certain types of media entertainment may influence certain children, (b) which children are particularly susceptible to positive, which to negative, and which to both positive and negative entertainment effects, and (c) how children s social environment can maximize positive and minimize negative entertainment effects on children. The project involves a longitudinal panel study among 900 Dutch families. To measure the variables in the model, we will use some well-established survey instruments and neuropsychological tests. We will also employ two less conventional methods (coded media-use diaries and experience sampling methods) that may enhance serendipity in the development of our theory-advancing insights. We will use state-of-the art data-analytic techniques (e.g., multi-level and latent-growth curve modelling) to analyse the data. Although adventurous, this transdisciplinary project, the first in its kind, has great theoretical significance. If the assumptions of my model are supported, it may lead to a fundamental re-evaluation of earlier media-effects theories and research on children. The project will also have tremendous social relevance, not only for parents, but also for programme makers, educators, and the society as a whole. After all, only if we truly understand why, how, and which children are influenced by certain types of media entertainment, are we able to adequately target prevention and intervention strategies at these children.
Max ERC Funding
2 500 000 €
Duration
Start date: 2010-12-01, End date: 2016-08-31
Project acronym FUNCTIONAL GENOMICS
Project DISSECTING GENETIC DEPENDENCIES IN CANCER
Researcher (PI) Rene Bernards
Host Institution (HI) STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
Country Netherlands
Call Details Advanced Grant (AdG), LS2, ERC-2009-AdG
Summary While significant progress has been made in the diagnosis and treatment of cancer, several major issues remain unresolved. First, only a minority of patients respond to most forms of (chemo)therapy. It is generally believed that this poor responsiveness to drugs has its origin, at least in part, in the molecular heterogeneity of cancer. This heterogeneity requires the use of biomarkers to stratify patients having seemingly similar tumors according to their likely responses to specific cancer therapies. To identify such biomarkers, we will use large-scale genetic screens to identify genes that are causally involved in controlling responses to cancer drugs. Such genes are likely biomarkers of drug responsiveness in the clinic. Availability of such drug response biomarkers will facilitate a more personalized therapy choice for each individual patient. A second major deficit in effective cancer therapy is the lack of sufficient highly selective drug targets. The large-scale cancer genome re-sequencing efforts already indicate that there is a paucity of druggable genes that are consistently mutated in cancer and the same holds true for genes that are consistently over-expressed in cancer. Hence, there is an urgent need for innovative drug targets that have a similar cancer-selectivity as the genes that are specifically mutated or over-expressed in cancer. In this project, we will use large-scale loss of function genetic screens, exploiting the concept of synthetic lethality , to identify genes whose inactivation is selectively toxic to cells having a defined cancer-specific genetic alteration. Drugs against these targets will be highly cancer-selective, as their activity hinges on the presence of a specific genetic defect, which is only present in the cancer cell.
Summary
While significant progress has been made in the diagnosis and treatment of cancer, several major issues remain unresolved. First, only a minority of patients respond to most forms of (chemo)therapy. It is generally believed that this poor responsiveness to drugs has its origin, at least in part, in the molecular heterogeneity of cancer. This heterogeneity requires the use of biomarkers to stratify patients having seemingly similar tumors according to their likely responses to specific cancer therapies. To identify such biomarkers, we will use large-scale genetic screens to identify genes that are causally involved in controlling responses to cancer drugs. Such genes are likely biomarkers of drug responsiveness in the clinic. Availability of such drug response biomarkers will facilitate a more personalized therapy choice for each individual patient. A second major deficit in effective cancer therapy is the lack of sufficient highly selective drug targets. The large-scale cancer genome re-sequencing efforts already indicate that there is a paucity of druggable genes that are consistently mutated in cancer and the same holds true for genes that are consistently over-expressed in cancer. Hence, there is an urgent need for innovative drug targets that have a similar cancer-selectivity as the genes that are specifically mutated or over-expressed in cancer. In this project, we will use large-scale loss of function genetic screens, exploiting the concept of synthetic lethality , to identify genes whose inactivation is selectively toxic to cells having a defined cancer-specific genetic alteration. Drugs against these targets will be highly cancer-selective, as their activity hinges on the presence of a specific genetic defect, which is only present in the cancer cell.
Max ERC Funding
2 176 000 €
Duration
Start date: 2010-06-01, End date: 2015-05-31
Project acronym INTERCOM
Project The Influence of Interfaces, Confinement and Compartmentalization on Chemical Reactions
Researcher (PI) Wilhelm Huck
Host Institution (HI) STICHTING KATHOLIEKE UNIVERSITEIT
Country Netherlands
Call Details Advanced Grant (AdG), PE4, ERC-2009-AdG
Summary Water is essential for life on our planet and is the solvent of choice for Nature to carry out her syntheses. In contrast, our methods of making complex organic molecules have taken us far away from the watery milieu of biosynthesis. Indeed, it is fair to say that most organic reactions commonly used both in academic laboratories and in industry fail in the presence of water or oxygen. At the same time of course, chemical reactors are very different from the cellular environment where Nature s synthesis is carried out. This research proposal aims to incorporate some of the key characteristic of cellular reactors, i.e. confinement, compartmentalization and interfaces, into model droplet-based reactors. The envisioned reactors will comprise of monodisperse aqueous droplets in oil carrier phases with volumes ranging from pL to nL, produced in microfluidics devices or in tubing, in very large numbers. These droplets will have precisely determined interfacial areas, which can be used for the study of so-called on water reactions, a new area of synthetic chemistry rapidly gaining in interest. Furthermore, the interfaces can be functionalized with catalytically active surfactants and by confining the droplets into ever decreasing volumes, the effect of nanoconfinement on enzymatic and other reactions can be studied. Finally, individual droplets provide a completely compartmentalized environment, suitable for the study of single enzymes in a crowded environment, but also for systematic studies into communication between compartmentalized, mutually incompatible, reaction systems. This proposal presents a radically new approach to increasing our understanding of chemical reactions in confined spaces and at interfaces and provides a technological platform for the creation of chemically linked networks with emerging complexity.
Summary
Water is essential for life on our planet and is the solvent of choice for Nature to carry out her syntheses. In contrast, our methods of making complex organic molecules have taken us far away from the watery milieu of biosynthesis. Indeed, it is fair to say that most organic reactions commonly used both in academic laboratories and in industry fail in the presence of water or oxygen. At the same time of course, chemical reactors are very different from the cellular environment where Nature s synthesis is carried out. This research proposal aims to incorporate some of the key characteristic of cellular reactors, i.e. confinement, compartmentalization and interfaces, into model droplet-based reactors. The envisioned reactors will comprise of monodisperse aqueous droplets in oil carrier phases with volumes ranging from pL to nL, produced in microfluidics devices or in tubing, in very large numbers. These droplets will have precisely determined interfacial areas, which can be used for the study of so-called on water reactions, a new area of synthetic chemistry rapidly gaining in interest. Furthermore, the interfaces can be functionalized with catalytically active surfactants and by confining the droplets into ever decreasing volumes, the effect of nanoconfinement on enzymatic and other reactions can be studied. Finally, individual droplets provide a completely compartmentalized environment, suitable for the study of single enzymes in a crowded environment, but also for systematic studies into communication between compartmentalized, mutually incompatible, reaction systems. This proposal presents a radically new approach to increasing our understanding of chemical reactions in confined spaces and at interfaces and provides a technological platform for the creation of chemically linked networks with emerging complexity.
Max ERC Funding
2 147 726 €
Duration
Start date: 2010-05-01, End date: 2015-04-30
Project acronym MLG
Project Causes and Consequences of Multilevel Governance
Researcher (PI) Gary Marks
Host Institution (HI) STICHTING VU
Country Netherlands
Call Details Advanced Grant (AdG), SH2, ERC-2009-AdG
Summary This five-year research programme is motivated by the question: Why does the structure of government vary, and how does this affect the quality of democracy and governance? The programme estimates and explains the scope and depth of authority exercised by subnational governments and international governmental organizations (IGOs) from 1950 to 2010. This will allow deeper understanding of a major policy development multilevel governance, the dispersion of authority away from central states to subnational and supranational levels. While major institutions, including the World Bank, the European Parliament, and European Commission recommend multilevel governance, some policy analysts claim that multilevel governance exacerbates corruption, leads to gridlock, engenders moral hazard, constrains redistribution, obfuscates accountability, and wastes money. However, comparative information about how international and subnational government varies across countries and over time is lacking, and so it is not possible to discipline normative claims against evidence. The contribution of the research programme is threefold. First, it provides carefully constructed, comparative, and reliable estimates of subnational and international government for a wide range of countries over an extended time period. Second, it seeks to advance understanding of the causes of multilevel governance, building on the major theories in the field. Third, it provides a rigorous assessment of the consequences of multilevel governance. Theories of the causes and consequences of multilevel governance will be evaluated quantitatively and in a case study of government response to climate change.
Summary
This five-year research programme is motivated by the question: Why does the structure of government vary, and how does this affect the quality of democracy and governance? The programme estimates and explains the scope and depth of authority exercised by subnational governments and international governmental organizations (IGOs) from 1950 to 2010. This will allow deeper understanding of a major policy development multilevel governance, the dispersion of authority away from central states to subnational and supranational levels. While major institutions, including the World Bank, the European Parliament, and European Commission recommend multilevel governance, some policy analysts claim that multilevel governance exacerbates corruption, leads to gridlock, engenders moral hazard, constrains redistribution, obfuscates accountability, and wastes money. However, comparative information about how international and subnational government varies across countries and over time is lacking, and so it is not possible to discipline normative claims against evidence. The contribution of the research programme is threefold. First, it provides carefully constructed, comparative, and reliable estimates of subnational and international government for a wide range of countries over an extended time period. Second, it seeks to advance understanding of the causes of multilevel governance, building on the major theories in the field. Third, it provides a rigorous assessment of the consequences of multilevel governance. Theories of the causes and consequences of multilevel governance will be evaluated quantitatively and in a case study of government response to climate change.
Max ERC Funding
2 478 807 €
Duration
Start date: 2010-05-01, End date: 2015-04-30
Project acronym MULTI-SCALE FLOWS
Project Multi-scale modeling of mass and heat transfer in dense gas-solid flows
Researcher (PI) Johannes Alfonsius Maria Kuipers
Host Institution (HI) TECHNISCHE UNIVERSITEIT EINDHOVEN
Country Netherlands
Call Details Advanced Grant (AdG), PE8, ERC-2009-AdG
Summary Dense gas-solid flows have been the subject of intense research over the past decades, owing to its wealth of scientifically interesting phenomena, as well as to its direct relevance for innumerable industrial applications. Dense gas solid flows are notoriously complex and its phenomena difficult to predict. This finds its origin in the large separation of relevant scales: particle-particle and particle-gas interactions at the microscale (< 1 mm) dictate the phenomena that occur at the macroscale (> 1 meter), the fundamental understanding of which poses a huge challenge for both the scientific and technological community. This proposal is aimed at providing a comprehensive understanding of large-scale dense gas-solid flow based on first principles, that is, based on the exchange of mass, momentum and heat at the surface of the individual solid particles, below the millimeter scale. To this end, we employ a multi-scale approach, where the gas-solid flow is described by three different models. Such an approach is by now widely recognized as the most rigorous and viable pathway to obtain a full understanding of dense-gas solid flow, and has become very topical in chemical engineering science. The unique aspect of this proposal is the scale and the comprehensiveness of the research: we want to consider, for the first time, the exchange of heat, momentum and energy, and the effects of polydispersity, heterogeneity, and domain geometries, at all three levels of modeling, and validated by one-to-one experiments. These generated insight and models will be extremely relevant for the design and scale-up of industrial equipment involving dispersed particulate flow, which is currently a fully empirical process, involving expensive and time-consuming experimentation.
Summary
Dense gas-solid flows have been the subject of intense research over the past decades, owing to its wealth of scientifically interesting phenomena, as well as to its direct relevance for innumerable industrial applications. Dense gas solid flows are notoriously complex and its phenomena difficult to predict. This finds its origin in the large separation of relevant scales: particle-particle and particle-gas interactions at the microscale (< 1 mm) dictate the phenomena that occur at the macroscale (> 1 meter), the fundamental understanding of which poses a huge challenge for both the scientific and technological community. This proposal is aimed at providing a comprehensive understanding of large-scale dense gas-solid flow based on first principles, that is, based on the exchange of mass, momentum and heat at the surface of the individual solid particles, below the millimeter scale. To this end, we employ a multi-scale approach, where the gas-solid flow is described by three different models. Such an approach is by now widely recognized as the most rigorous and viable pathway to obtain a full understanding of dense-gas solid flow, and has become very topical in chemical engineering science. The unique aspect of this proposal is the scale and the comprehensiveness of the research: we want to consider, for the first time, the exchange of heat, momentum and energy, and the effects of polydispersity, heterogeneity, and domain geometries, at all three levels of modeling, and validated by one-to-one experiments. These generated insight and models will be extremely relevant for the design and scale-up of industrial equipment involving dispersed particulate flow, which is currently a fully empirical process, involving expensive and time-consuming experimentation.
Max ERC Funding
2 500 000 €
Duration
Start date: 2010-03-01, End date: 2015-02-28
Project acronym OPTION
Project Optimizing Policies for Transport: accounting for Industrial Organisation in Network markets
Researcher (PI) Erik Teodoor Verhoef
Host Institution (HI) STICHTING VU
Country Netherlands
Call Details Advanced Grant (AdG), SH3, ERC-2009-AdG
Summary Traditional models of transport networks ignore the existence and strategic behaviour of large actors who are often active in transport markets. Examples of such large actors are private infrastructure or service operators, insurance companies, or vehicle manufacturers. Both for positive and normative analyses, this omission can lead to substantial errors, and therefore to seriously biased policy evaluations and recommendations. The reason is that such actors will have their own objectives to pursue, while their market power gives them ample opportunity to influence market outcomes through strategic behaviour. Ignoring their behavioural responses to policy changes therefore leads to a wrong prediction of the policy s optimal design as well as its impacts. An important reason why they are nevertheless usually ignored is the analytical and numerical complexity of transport network models in which large actors, with strategic behaviour, are active. This project seeks to develop such models. Specific applications will include models of road transport networks allowing for private road operators, vehicle manufacturers, and insurance companies; models of urban taxi markets; and networks models for public transport and aviation. Although applying to different cases, these models will have important methodological characteristics in common, particularly in that they apply multilevel optimization techniques for (transport) network models that account for strategic behaviour of and interactions between large actors. We will investigate how this behaviour affects the formation of network equilibria in transport markets, as well as the impacts and (second-best) optimal design of transport policies.
Summary
Traditional models of transport networks ignore the existence and strategic behaviour of large actors who are often active in transport markets. Examples of such large actors are private infrastructure or service operators, insurance companies, or vehicle manufacturers. Both for positive and normative analyses, this omission can lead to substantial errors, and therefore to seriously biased policy evaluations and recommendations. The reason is that such actors will have their own objectives to pursue, while their market power gives them ample opportunity to influence market outcomes through strategic behaviour. Ignoring their behavioural responses to policy changes therefore leads to a wrong prediction of the policy s optimal design as well as its impacts. An important reason why they are nevertheless usually ignored is the analytical and numerical complexity of transport network models in which large actors, with strategic behaviour, are active. This project seeks to develop such models. Specific applications will include models of road transport networks allowing for private road operators, vehicle manufacturers, and insurance companies; models of urban taxi markets; and networks models for public transport and aviation. Although applying to different cases, these models will have important methodological characteristics in common, particularly in that they apply multilevel optimization techniques for (transport) network models that account for strategic behaviour of and interactions between large actors. We will investigate how this behaviour affects the formation of network equilibria in transport markets, as well as the impacts and (second-best) optimal design of transport policies.
Max ERC Funding
2 493 318 €
Duration
Start date: 2010-05-01, End date: 2015-04-30
Project acronym SHARES
Project Shared Responsibility in International Law
Researcher (PI) Peter Andreas Nollkaemper
Host Institution (HI) UNIVERSITEIT VAN AMSTERDAM
Country Netherlands
Call Details Advanced Grant (AdG), SH2, ERC-2009-AdG
Summary SHARES seeks to rethink the allocation of international responsibilities in cases where actors cooperate to pursue common international objectives, for example environmental protection and protection of human populations from mass atrocities. International cooperation may complicate attempts to determine who is responsible for what. SHARES is based on the unrecognized and unexplored fact that as the responsibility for policies is shared among more actors, the discrete responsibility of every individual actor is diminished proportionately. International cooperation paradoxically may undermine the key objectives of any scheme of responsibility : the protection of the international rule of law and the provision of remedies of injured parties. The dominant principle of individual responsibility, and the scholarship based on it, provides us neither with the concepts nor the perspectives for addressing shared responsibilities. SHARES will uncover the extent and nature of the problem of scattering of international responsibilities in cases of international cooperation and will provide fresh perspectives on how cooperation can be better matched by a corresponding system of international responsibility. It will pursue two interlocking tracks, focussing on principles and processes of international responsibility. As to principles, it will examine the possibility of holding multiple actors collectively, jointly or proportionately responsible. As to processes, SHARES will rethink how (quasi-)judicial processes may better taken into account the collective context of the international policies of states and other actors. SHARES will complement a conceptual and theoretical foundation with a thorough empirical approach, exploring through case-studies how we can improve our understanding of the principles and processes that are needed to match the unprecedented international cooperation with a proper system of shared responsibility.
Summary
SHARES seeks to rethink the allocation of international responsibilities in cases where actors cooperate to pursue common international objectives, for example environmental protection and protection of human populations from mass atrocities. International cooperation may complicate attempts to determine who is responsible for what. SHARES is based on the unrecognized and unexplored fact that as the responsibility for policies is shared among more actors, the discrete responsibility of every individual actor is diminished proportionately. International cooperation paradoxically may undermine the key objectives of any scheme of responsibility : the protection of the international rule of law and the provision of remedies of injured parties. The dominant principle of individual responsibility, and the scholarship based on it, provides us neither with the concepts nor the perspectives for addressing shared responsibilities. SHARES will uncover the extent and nature of the problem of scattering of international responsibilities in cases of international cooperation and will provide fresh perspectives on how cooperation can be better matched by a corresponding system of international responsibility. It will pursue two interlocking tracks, focussing on principles and processes of international responsibility. As to principles, it will examine the possibility of holding multiple actors collectively, jointly or proportionately responsible. As to processes, SHARES will rethink how (quasi-)judicial processes may better taken into account the collective context of the international policies of states and other actors. SHARES will complement a conceptual and theoretical foundation with a thorough empirical approach, exploring through case-studies how we can improve our understanding of the principles and processes that are needed to match the unprecedented international cooperation with a proper system of shared responsibility.
Max ERC Funding
2 113 949 €
Duration
Start date: 2010-05-01, End date: 2015-10-31
Project acronym SUPOCOSYS
Project From Supramolecular Polymers to Compartmentalized Systems
Researcher (PI) Egbert Willem Meijer
Host Institution (HI) TECHNISCHE UNIVERSITEIT EINDHOVEN
Country Netherlands
Call Details Advanced Grant (AdG), PE5, ERC-2009-AdG
Summary This ERC Grant proposal aims to explore the many challenges offered by non-covalent synthesis of functional supramolecular systems. This proposal will use the many possibilities of supramolecular polymers and how we envisage the construction of supramolecular compartmentalized systems based on specific secondary interactions. By studying the mechanisms of the formation of supramolecular polymers, new entrees are foreseen to limit the degree of supramolecular polymers by anti-cooperative mechanisms and to control both the depolymerization and polymerization aiming at supramolecular polymerization processes out of equilibrium. These insights will be used to design, synthesize and self-assembly materials that dynamically adapt their properties to cells that are brought in contact with these biomaterials. With these materials, parts of a bioartificial kidney will be made. With all the knowledge obtained through the years, we have recently introduced a concept to stepwise create folded macromolecules making use of our well-known supramolecular units. These single chain nanoparticles with internal structure are now proposed to be the starting point for making compartmentalized three-dimensional systems that possess functionality similar to proteins. Therefore, also novel techniques to synthesize well-defined polymers are introduced.
Summary
This ERC Grant proposal aims to explore the many challenges offered by non-covalent synthesis of functional supramolecular systems. This proposal will use the many possibilities of supramolecular polymers and how we envisage the construction of supramolecular compartmentalized systems based on specific secondary interactions. By studying the mechanisms of the formation of supramolecular polymers, new entrees are foreseen to limit the degree of supramolecular polymers by anti-cooperative mechanisms and to control both the depolymerization and polymerization aiming at supramolecular polymerization processes out of equilibrium. These insights will be used to design, synthesize and self-assembly materials that dynamically adapt their properties to cells that are brought in contact with these biomaterials. With these materials, parts of a bioartificial kidney will be made. With all the knowledge obtained through the years, we have recently introduced a concept to stepwise create folded macromolecules making use of our well-known supramolecular units. These single chain nanoparticles with internal structure are now proposed to be the starting point for making compartmentalized three-dimensional systems that possess functionality similar to proteins. Therefore, also novel techniques to synthesize well-defined polymers are introduced.
Max ERC Funding
1 947 937 €
Duration
Start date: 2010-04-01, End date: 2015-03-31