Project acronym CancerADAPT
Project Targeting the adaptive capacity of prostate cancer through the manipulation of transcriptional and metabolic traits
Researcher (PI) Arkaitz CARRACEDO PEREZ
Host Institution (HI) ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS
Call Details Consolidator Grant (CoG), LS4, ERC-2018-COG
Summary The composition and molecular features of tumours vary during the course of the disease, and the selection pressure imposed by the environment is a central component in this process. Evolutionary principles have been exploited to explain the genomic aberrations in cancer. However, the phenotypic changes underlying disease progression remain poorly understood. In the past years, I have contributed to identify and characterise the therapeutic implications underlying metabolic alterations that are intrinsic to primary tumours or metastasis. In CancerADAPT I postulate that cancer cells rely on adaptive transcriptional & metabolic mechanisms [converging on a Metabolic Phenotype] in order to rapidly succeed in their establishment in new microenvironments along disease progression. I aim to predict the molecular cues that govern the adaptive properties in prostate cancer (PCa), one of the most commonly diagnosed cancers in men and an important source of cancer-related deaths. I will exploit single cell RNASeq, spatial transcriptomics and multiregional OMICs in order to identify the transcriptional and metabolic diversity within tumours and along disease progression. I will complement experimental strategies with computational analyses that identify and classify the predicted adaptation strategies of PCa cells in response to variations in the tumour microenvironment. Metabolic phenotypes postulated to sustain PCa adaptability will be functionally and mechanistically deconstructed. We will identify therapeutic strategies emanating from these results through in silico methodologies and small molecule high-throughput screening, and evaluate their potential to hamper the adaptability of tumour cells in vitro and in vivo, in two specific aspects: metastasis and therapy response. CancerADAPT will generate fundamental understanding on how cancer cells adapt in our organism, in turn leading to therapeutic strategies that increase the efficacy of current treatments.
Summary
The composition and molecular features of tumours vary during the course of the disease, and the selection pressure imposed by the environment is a central component in this process. Evolutionary principles have been exploited to explain the genomic aberrations in cancer. However, the phenotypic changes underlying disease progression remain poorly understood. In the past years, I have contributed to identify and characterise the therapeutic implications underlying metabolic alterations that are intrinsic to primary tumours or metastasis. In CancerADAPT I postulate that cancer cells rely on adaptive transcriptional & metabolic mechanisms [converging on a Metabolic Phenotype] in order to rapidly succeed in their establishment in new microenvironments along disease progression. I aim to predict the molecular cues that govern the adaptive properties in prostate cancer (PCa), one of the most commonly diagnosed cancers in men and an important source of cancer-related deaths. I will exploit single cell RNASeq, spatial transcriptomics and multiregional OMICs in order to identify the transcriptional and metabolic diversity within tumours and along disease progression. I will complement experimental strategies with computational analyses that identify and classify the predicted adaptation strategies of PCa cells in response to variations in the tumour microenvironment. Metabolic phenotypes postulated to sustain PCa adaptability will be functionally and mechanistically deconstructed. We will identify therapeutic strategies emanating from these results through in silico methodologies and small molecule high-throughput screening, and evaluate their potential to hamper the adaptability of tumour cells in vitro and in vivo, in two specific aspects: metastasis and therapy response. CancerADAPT will generate fundamental understanding on how cancer cells adapt in our organism, in turn leading to therapeutic strategies that increase the efficacy of current treatments.
Max ERC Funding
1 999 882 €
Duration
Start date: 2019-11-01, End date: 2024-10-31
Project acronym ECHO
Project Extending Coherence for Hardware-Driven Optimizations in Multicore Architectures
Researcher (PI) Alberto ROS BARDISA
Host Institution (HI) UNIVERSIDAD DE MURCIA
Call Details Consolidator Grant (CoG), PE6, ERC-2018-COG
Summary Multicore processors are present nowadays in most digital devices, from smartphones to high-performance
servers. The increasing computational power of these processors is essential for enabling many important
emerging application domains such as big-data, media, medical, or scientific modeling. A fundamental
technique to improve performance is speculation, a technique that consists in executing work before it is
known if it is actually needed. In hardware, speculation significantly increases energy consumption by
performing unnecessary operations, while speculation in software (e.g., compilers) is not the default thus
preventing performance optimizations. Since performance in current multicores is limited by their power
budget, it is imperative to make multicores as energy-efficient as possible to increase performance even
further.
In a multicore architecture, the cache coherence protocol is an essential component since its unique but
challenging role is to offer a simple and unified view of the memory hierarchy. This project envisions that
extending the role of the coherence protocol to simplify other system components will be the key to
overcome the performance and energy limitations of current multicores. In particular, ECHO proposes to
add simple but effective extensions to the cache coherence protocol in order to (i) reduce and even
eliminate misspeculations at the processing cores and synchronization mechanisms and to (ii) enable
speculative optimizations at compile time. The goal of this innovative approach is to improve the
performance and energy efficiency of future multicore architectures. To accomplish the objectives
proposed in this project, I will build on my 14 years expertise in cache coherence, documented in over 40
publications of high impact.
Summary
Multicore processors are present nowadays in most digital devices, from smartphones to high-performance
servers. The increasing computational power of these processors is essential for enabling many important
emerging application domains such as big-data, media, medical, or scientific modeling. A fundamental
technique to improve performance is speculation, a technique that consists in executing work before it is
known if it is actually needed. In hardware, speculation significantly increases energy consumption by
performing unnecessary operations, while speculation in software (e.g., compilers) is not the default thus
preventing performance optimizations. Since performance in current multicores is limited by their power
budget, it is imperative to make multicores as energy-efficient as possible to increase performance even
further.
In a multicore architecture, the cache coherence protocol is an essential component since its unique but
challenging role is to offer a simple and unified view of the memory hierarchy. This project envisions that
extending the role of the coherence protocol to simplify other system components will be the key to
overcome the performance and energy limitations of current multicores. In particular, ECHO proposes to
add simple but effective extensions to the cache coherence protocol in order to (i) reduce and even
eliminate misspeculations at the processing cores and synchronization mechanisms and to (ii) enable
speculative optimizations at compile time. The goal of this innovative approach is to improve the
performance and energy efficiency of future multicore architectures. To accomplish the objectives
proposed in this project, I will build on my 14 years expertise in cache coherence, documented in over 40
publications of high impact.
Max ERC Funding
1 999 955 €
Duration
Start date: 2019-09-01, End date: 2024-08-31
Project acronym ENFORCE
Project ENgineering FrustratiOn in aRtificial Colloidal icEs:degeneracy, exotic lattices and 3D states
Researcher (PI) pietro TIERNO
Host Institution (HI) UNIVERSITAT DE BARCELONA
Call Details Consolidator Grant (CoG), PE3, ERC-2018-COG
Summary Geometric frustration, namely the impossibility of satisfying competing interactions on a lattice, has recently
become a topic of considerable interest as it engenders emergent, fundamentally new phenomena and holds
the exciting promise of delivering a new class of nanoscale devices based on the motion of magnetic charges.
With ENFORCE, I propose to realize two and three dimensional artificial colloidal ices and investigate the
fascinating manybody physics of geometric frustration in these mesoscopic structures. I will use these soft
matter systems to engineer novel frustrated states through independent control of the single particle
positions, lattice topology and collective magnetic coupling. The three project work packages (WPs) will
present increasing levels of complexity, challenge and ambition:
(i) In WP1, I will demonstrate a way to restore the residual entropy in the square ice, a fundamental longstanding
problem in the field. Furthermore, I will miniaturize the square and the honeycomb geometries and investigate the dynamics of thermally excited topological defects and the formation of grain boundaries.
(ii) In WP2, I will decimate both lattices and realize mixed coordination geometries, where the similarity
between the colloidal and spin ice systems breaks down. I will then develop a novel annealing protocol based
on the simultaneous system visualization and magnetic actuation control.
(iii) In WP3, I will realize a three dimensional artificial colloidal ice, in which interacting ferromagnetic
inclusions will be located in the voids of an inverse opal, and arranged to form the FCC or the pyrochlore
lattices. External fields will be used to align, bias and stir these magnetic inclusions while monitoring in situ
their orientation and dynamics via laser scanning confocal microscopy.
ENFORCE will exploit the accessible time and length scales of the colloidal ice to shed new light on the
exciting and interdisciplinary field of geometric frustration.
Summary
Geometric frustration, namely the impossibility of satisfying competing interactions on a lattice, has recently
become a topic of considerable interest as it engenders emergent, fundamentally new phenomena and holds
the exciting promise of delivering a new class of nanoscale devices based on the motion of magnetic charges.
With ENFORCE, I propose to realize two and three dimensional artificial colloidal ices and investigate the
fascinating manybody physics of geometric frustration in these mesoscopic structures. I will use these soft
matter systems to engineer novel frustrated states through independent control of the single particle
positions, lattice topology and collective magnetic coupling. The three project work packages (WPs) will
present increasing levels of complexity, challenge and ambition:
(i) In WP1, I will demonstrate a way to restore the residual entropy in the square ice, a fundamental longstanding
problem in the field. Furthermore, I will miniaturize the square and the honeycomb geometries and investigate the dynamics of thermally excited topological defects and the formation of grain boundaries.
(ii) In WP2, I will decimate both lattices and realize mixed coordination geometries, where the similarity
between the colloidal and spin ice systems breaks down. I will then develop a novel annealing protocol based
on the simultaneous system visualization and magnetic actuation control.
(iii) In WP3, I will realize a three dimensional artificial colloidal ice, in which interacting ferromagnetic
inclusions will be located in the voids of an inverse opal, and arranged to form the FCC or the pyrochlore
lattices. External fields will be used to align, bias and stir these magnetic inclusions while monitoring in situ
their orientation and dynamics via laser scanning confocal microscopy.
ENFORCE will exploit the accessible time and length scales of the colloidal ice to shed new light on the
exciting and interdisciplinary field of geometric frustration.
Max ERC Funding
1 850 298 €
Duration
Start date: 2020-01-01, End date: 2024-12-31
Project acronym FeMiT
Project Ferrites-by-design for Millimeter-wave and Terahertz Technologies
Researcher (PI) Martí GICH
Host Institution (HI) AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Call Details Consolidator Grant (CoG), PE8, ERC-2018-COG
Summary Robust disruptive materials will be essential for the “wireless everywhere” to become a reality. This is because we need a paradigm shift in mobile communications to meet the challenges of such an ambitious evolution. In particular, some of these emerging technologies will trigger the replacement of the magnetic microwave ferrites in use today. This will namely occur with the forecasted shift to high frequency mm-wave and THz bands and in novel antennas that can simultaneously transmit and receive data on the same frequency. In both cases, operating with state-of-the-art ferrites would require large external magnetic fields incompatible with future needs of smaller, power-efficient devices.
To overcome these issues, we target ferrites featuring the so far unmet combinations of low magnetic loss and large values of magnetocrystalline anisotropy, magnetostriction or magnetoelectric coupling.
The objective of FeMiT is developing a novel family of orthorhombic ferrites based on ε-Fe2O3, a room-temperature multiferroic with large magnetocrystalline anisotropy. Those properties and unique structural features make it an excellent platform to develop the sought-after functional materials for future compact and energy-efficient wireless devices.
In the first part of FeMiT we will explore the limits and diversity of this new family by exploiting rational chemical substitutions, high pressures and strain engineering. Soft chemistry and physical deposition methods will be both considered at this stage.
The second part of FeMiT entails a characterization of functional properties and selection of the best candidates to be integrated in composite and epitaxial films suitable for application. The expected outcomes will provide proof-of-concept self-biased or voltage-controlled signal-processing devices with low losses in the mm-wave to THz bands, with high potential impact in the development of future wireless technologies.
Summary
Robust disruptive materials will be essential for the “wireless everywhere” to become a reality. This is because we need a paradigm shift in mobile communications to meet the challenges of such an ambitious evolution. In particular, some of these emerging technologies will trigger the replacement of the magnetic microwave ferrites in use today. This will namely occur with the forecasted shift to high frequency mm-wave and THz bands and in novel antennas that can simultaneously transmit and receive data on the same frequency. In both cases, operating with state-of-the-art ferrites would require large external magnetic fields incompatible with future needs of smaller, power-efficient devices.
To overcome these issues, we target ferrites featuring the so far unmet combinations of low magnetic loss and large values of magnetocrystalline anisotropy, magnetostriction or magnetoelectric coupling.
The objective of FeMiT is developing a novel family of orthorhombic ferrites based on ε-Fe2O3, a room-temperature multiferroic with large magnetocrystalline anisotropy. Those properties and unique structural features make it an excellent platform to develop the sought-after functional materials for future compact and energy-efficient wireless devices.
In the first part of FeMiT we will explore the limits and diversity of this new family by exploiting rational chemical substitutions, high pressures and strain engineering. Soft chemistry and physical deposition methods will be both considered at this stage.
The second part of FeMiT entails a characterization of functional properties and selection of the best candidates to be integrated in composite and epitaxial films suitable for application. The expected outcomes will provide proof-of-concept self-biased or voltage-controlled signal-processing devices with low losses in the mm-wave to THz bands, with high potential impact in the development of future wireless technologies.
Max ERC Funding
1 989 967 €
Duration
Start date: 2019-05-01, End date: 2024-04-30
Project acronym InOutBioLight
Project Advanced biohybrid lighting and photovoltaic devices
Researcher (PI) Rubén Darío COSTA
Host Institution (HI) FUNDACION IMDEA MATERIALES
Call Details Consolidator Grant (CoG), PE5, ERC-2018-COG
Summary InOutBioLight aims to design multifunctional rubbers with enhanced mechanical, thermal, color-converting, and light-guiding features towards advanced biohybrid lighting and photovoltaic technologies. The latter are placed at the forefront of the EU efforts for low-cost production and efficient consumption of electricity, a critical issue for a sustainable development.
In this context, the use of biomolecules as functional components in lighting and photovoltaic devices is still a challenge, as they quickly denature under storage and device operation conditions. This paradigm has changed using an innovative rubber-like material, in which the biofunctionality is long preserved. As a proof-of-concept, color down-converting rubbers based on fluorescent proteins were used to design the first biohybrid white light-emitting diode (bio-HWLED). To develop a new generation of biohybrid devices, InOutBioLight will address the following critical issues, namely i) the nature of the protein-matrix stabilization, ii) how to enhance the thermal/mechanical features, iii) how to design multifunctional rubbers, iv) how to mimic natural patterns for light-guiding, and v) how to expand the technological use of the rubber approach.
To achieve these goals, InOutBioLight involves comprehensive spectroscopic, microscopic, and mechanical studies to investigate the protein-matrix interaction using new polymer matrices, additives, and protein-based nanoparticles. In addition, the mechanical, thermal, and light-coupling features will be enhanced using structural biocompounds and reproducing biomorphic patterns. As such, InOutBioLight offers three major advances: i) a thorough scientific basis for the rubber approach, ii) a significant thrust of the emerging bio-HWLEDs, and iii) innovative breakthroughs beyond state-of-the-art biohybrid solar cells.
Summary
InOutBioLight aims to design multifunctional rubbers with enhanced mechanical, thermal, color-converting, and light-guiding features towards advanced biohybrid lighting and photovoltaic technologies. The latter are placed at the forefront of the EU efforts for low-cost production and efficient consumption of electricity, a critical issue for a sustainable development.
In this context, the use of biomolecules as functional components in lighting and photovoltaic devices is still a challenge, as they quickly denature under storage and device operation conditions. This paradigm has changed using an innovative rubber-like material, in which the biofunctionality is long preserved. As a proof-of-concept, color down-converting rubbers based on fluorescent proteins were used to design the first biohybrid white light-emitting diode (bio-HWLED). To develop a new generation of biohybrid devices, InOutBioLight will address the following critical issues, namely i) the nature of the protein-matrix stabilization, ii) how to enhance the thermal/mechanical features, iii) how to design multifunctional rubbers, iv) how to mimic natural patterns for light-guiding, and v) how to expand the technological use of the rubber approach.
To achieve these goals, InOutBioLight involves comprehensive spectroscopic, microscopic, and mechanical studies to investigate the protein-matrix interaction using new polymer matrices, additives, and protein-based nanoparticles. In addition, the mechanical, thermal, and light-coupling features will be enhanced using structural biocompounds and reproducing biomorphic patterns. As such, InOutBioLight offers three major advances: i) a thorough scientific basis for the rubber approach, ii) a significant thrust of the emerging bio-HWLEDs, and iii) innovative breakthroughs beyond state-of-the-art biohybrid solar cells.
Max ERC Funding
1 999 188 €
Duration
Start date: 2020-01-01, End date: 2024-12-31
Project acronym LArcHer
Project Breaking barriers between Science and Heritage approaches to Levantine Rock Art through Archaeology, Heritage Science and IT
Researcher (PI) Ines DOMINGO SANZ
Host Institution (HI) UNIVERSITAT DE BARCELONA
Call Details Consolidator Grant (CoG), SH6, ERC-2018-COG
Summary LArcHer project aims at pioneering a new and more comprehensive way of understanding one of Europe’s most extraordinary bodies of prehistoric art, awarded Unesco World Heritage status in 1998: Levantine rock art (LRA). The ground-breaking nature of the project relies on combining a multidisciplinary (Archaeology, Heritage Science and IT) and multiscale approach (from microanalysis to landscape perspectives) to gain a holistic view of this art. It also aims at closing existing gaps between science and heritage mainstreams, to better understand the values and threats affecting this tradition and bring about a change in the way we understand, care, use and manage this millenary legacy. LArcHer aims are: a) Use cross-disciplinary knowledge and methods to redefine LRA (i.e. new dating techniques to refine chronology, new analytical methods to understand the creative process); b) Use LRA as a proxy to raise new questions of global interest on the evolution of creative thinking and human cognition (i.e. the timing and driving forces behind the birth of anthropocentrism and visual narratives in the history of prehistoric art); c) Develop new research agendas to set off complementary goals between science and heritage and define best practices for open air rock art conservation and management.
Spread across Mediterranean Iberia, LRA is the only European body of figurative art dominated by humans engaged in dynamic narratives of hunting, violence, warfare, dances and so forth. These scenes are unique to explore past social dynamics, human behaviour and cultural practices. As such, it is the only body of European rock art with potential to answer some of the new questions raised by LArcHer.
Key to LArcHer are the systematic recording and analysis of the art through 3D Digital technologies, management and data storage systems, GIS, physicochemical analysis of pigments and bedrock and comparative analysis with other major bodies of art with equivalent developments.
Summary
LArcHer project aims at pioneering a new and more comprehensive way of understanding one of Europe’s most extraordinary bodies of prehistoric art, awarded Unesco World Heritage status in 1998: Levantine rock art (LRA). The ground-breaking nature of the project relies on combining a multidisciplinary (Archaeology, Heritage Science and IT) and multiscale approach (from microanalysis to landscape perspectives) to gain a holistic view of this art. It also aims at closing existing gaps between science and heritage mainstreams, to better understand the values and threats affecting this tradition and bring about a change in the way we understand, care, use and manage this millenary legacy. LArcHer aims are: a) Use cross-disciplinary knowledge and methods to redefine LRA (i.e. new dating techniques to refine chronology, new analytical methods to understand the creative process); b) Use LRA as a proxy to raise new questions of global interest on the evolution of creative thinking and human cognition (i.e. the timing and driving forces behind the birth of anthropocentrism and visual narratives in the history of prehistoric art); c) Develop new research agendas to set off complementary goals between science and heritage and define best practices for open air rock art conservation and management.
Spread across Mediterranean Iberia, LRA is the only European body of figurative art dominated by humans engaged in dynamic narratives of hunting, violence, warfare, dances and so forth. These scenes are unique to explore past social dynamics, human behaviour and cultural practices. As such, it is the only body of European rock art with potential to answer some of the new questions raised by LArcHer.
Key to LArcHer are the systematic recording and analysis of the art through 3D Digital technologies, management and data storage systems, GIS, physicochemical analysis of pigments and bedrock and comparative analysis with other major bodies of art with equivalent developments.
Max ERC Funding
1 991 178 €
Duration
Start date: 2019-10-01, End date: 2024-09-30
Project acronym MAGNESIA
Project The impact of highly magnetic neutron stars in the explosive and transient Universe
Researcher (PI) Nanda Rea
Host Institution (HI) AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Call Details Consolidator Grant (CoG), PE9, ERC-2018-COG
Summary The gravitational wave window is now open. It is then imperative to build quantitative models of neutron stars that use all the available tracers to constrain fundamental physics at the highest densities and magnetic fields. The most magnetic neutron stars, the magnetars, have been recently suggested to be powering a large variety of explosive and transient events. The enormous rotational power at birth, and the magnetic energy they can release via large flares, put the magnetars in the (yet) hand-wavy interpretations of gamma-ray bursts, the early phases of double neutron star mergers, super-luminous supernovae, hypernovae, fast radio bursts, and ultra-luminous X-ray sources. However, despite knowing about 30 magnetars, we are lacking a census of how many we expect within the pulsar population, nor we have robust constraints on their flaring rates. The recent discovery of transient magnetars, of magnetar-like flares from sources with measured low dipolar magnetic fields and from typical radio pulsars, clearly showed that the magnetar census in our Galaxy is largely under-estimated. This hampers our understanding not only of the pulsar and magnetar populations, but also of them as possibly related to many of Universe’s explosive events. MAGNESIA will infer a sound Magnetar Census via an innovative approach that will build the first Pulsar Population Synthesis model able to cope with constraints/limits from multi-band observations, and taking into account 3D magnetic field evolution models and flaring rates for neutron stars. Combining expertise in multi-band observations, numerical modeling, nuclear physics, and computation, MAGNESIA will solve the physics, the observational systematic errors, and the computational challenges that inhibited previous works, to finally constrain the spin period and magnetic field distribution at birth of the neutron star population.
Summary
The gravitational wave window is now open. It is then imperative to build quantitative models of neutron stars that use all the available tracers to constrain fundamental physics at the highest densities and magnetic fields. The most magnetic neutron stars, the magnetars, have been recently suggested to be powering a large variety of explosive and transient events. The enormous rotational power at birth, and the magnetic energy they can release via large flares, put the magnetars in the (yet) hand-wavy interpretations of gamma-ray bursts, the early phases of double neutron star mergers, super-luminous supernovae, hypernovae, fast radio bursts, and ultra-luminous X-ray sources. However, despite knowing about 30 magnetars, we are lacking a census of how many we expect within the pulsar population, nor we have robust constraints on their flaring rates. The recent discovery of transient magnetars, of magnetar-like flares from sources with measured low dipolar magnetic fields and from typical radio pulsars, clearly showed that the magnetar census in our Galaxy is largely under-estimated. This hampers our understanding not only of the pulsar and magnetar populations, but also of them as possibly related to many of Universe’s explosive events. MAGNESIA will infer a sound Magnetar Census via an innovative approach that will build the first Pulsar Population Synthesis model able to cope with constraints/limits from multi-band observations, and taking into account 3D magnetic field evolution models and flaring rates for neutron stars. Combining expertise in multi-band observations, numerical modeling, nuclear physics, and computation, MAGNESIA will solve the physics, the observational systematic errors, and the computational challenges that inhibited previous works, to finally constrain the spin period and magnetic field distribution at birth of the neutron star population.
Max ERC Funding
2 263 148 €
Duration
Start date: 2019-06-01, End date: 2024-05-31
Project acronym MarsFirstWater
Project The physicochemical nature of water on early Mars
Researcher (PI) Alberto Gonzalez Fairen
Host Institution (HI) AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Call Details Consolidator Grant (CoG), PE9, ERC-2018-COG
Summary Concepts of large bodies of glacial ice and liquid standing water, a robust hydrological cycle, and a rich Martian history of climate change are part of the current consensus model for early Mars. However, questions still poorly constrained include: a precise understanding of the inventory of water during the first billion years of Mars history and its early evolution on both global and local scales; whether liquid or solid H2O dominated, for what duration of time and where the water resided; what were the host-rock weathering rates and patterns and the physicochemical parameters defining such interactions; what specific landforms and mineralogies were generated during those periods; and what implications all these processes had on the possible inception of life on Mars. These fundamental questions represent large uncertainties and knowledge gaps. Therefore, a quantitative understanding of the basic characteristics of water on early Mars is very much needed and is the focus of this proposal.
This application outlines a plan for my research in the next five years, and explains how I propose to fully characterize the aqueous environments of early Mars through a quantitative and truly interdisciplinary investigation. Spacecraft mission-derived datasets will be consistently used to test hypotheses through paleogeomorphological reconstructions, geochemical modeling, mineralogical studies, and astrobiological investigations. The derived results will produce hard constraints on the physical evolution, chemical alteration and habitability of surface and near-surface aqueous environments on early Mars. The planned investigations will benefit from the combination of working with first-hand data from ongoing Mars missions and with the state-of-the-art laboratory tools at the host institution. The final expected result will be a complete understanding of the physicochemical nature of water on early Mars, also opening new paths for the astrobiological exploration of the planet.
Summary
Concepts of large bodies of glacial ice and liquid standing water, a robust hydrological cycle, and a rich Martian history of climate change are part of the current consensus model for early Mars. However, questions still poorly constrained include: a precise understanding of the inventory of water during the first billion years of Mars history and its early evolution on both global and local scales; whether liquid or solid H2O dominated, for what duration of time and where the water resided; what were the host-rock weathering rates and patterns and the physicochemical parameters defining such interactions; what specific landforms and mineralogies were generated during those periods; and what implications all these processes had on the possible inception of life on Mars. These fundamental questions represent large uncertainties and knowledge gaps. Therefore, a quantitative understanding of the basic characteristics of water on early Mars is very much needed and is the focus of this proposal.
This application outlines a plan for my research in the next five years, and explains how I propose to fully characterize the aqueous environments of early Mars through a quantitative and truly interdisciplinary investigation. Spacecraft mission-derived datasets will be consistently used to test hypotheses through paleogeomorphological reconstructions, geochemical modeling, mineralogical studies, and astrobiological investigations. The derived results will produce hard constraints on the physical evolution, chemical alteration and habitability of surface and near-surface aqueous environments on early Mars. The planned investigations will benefit from the combination of working with first-hand data from ongoing Mars missions and with the state-of-the-art laboratory tools at the host institution. The final expected result will be a complete understanding of the physicochemical nature of water on early Mars, also opening new paths for the astrobiological exploration of the planet.
Max ERC Funding
1 998 368 €
Duration
Start date: 2019-06-01, End date: 2024-05-31
Project acronym MATRIX
Project Novel mitochondria-targeted therapies for cancer treatment-induced cardiotoxicity
Researcher (PI) Borja Ibáñez Cabeza
Host Institution (HI) CENTRO NACIONAL DE INVESTIGACIONESCARDIOVASCULARES CARLOS III (F.S.P.)
Call Details Consolidator Grant (CoG), LS7, ERC-2018-COG
Summary Cardiac toxicity is one of the most frequent serious side effects of cancer therapy, affecting up to 30% of treated patients. Cancer treatment-induced cardiotoxicity (CTiCT) can result in severe heart failure. The trade-off between cancer and chronic heart failure is an immense personal burden with physical and psychological consequences. Current therapies for CTiCT are suboptimal, featuring poor early detection algorithms and nonspecific heart failure treatments. Based on our recently published results and additional preliminary data presented here, we propose that CTiCT is associated with altered mitochondrial dynamics, triggering a cardiomyocyte metabolic reprogramming. MATRIX represents a holistic approach to tackling mitochondrial dysfunction in CTiCT. Our hypothesis is that reverting metabolic reprogramming by shifting mitochondrial substrate utilization could represent a new paradigm in the treatment of early-stage CTiCT. By refining a novel imaging-based algorithm recently developed in our group, we will achieve very early detection of myocardial damage in patients treated with commonly prescribed cancer therapies, long before clinically used parameters become abnormal. Such early detection, not available currently, is crucial for implementation of early therapies. We also hypothesize that in end-stage CTiCT, mitochondrial dysfunction has passed a no-return point, and the failing heart will only be rescued by a strategy to replenish the myocardium with fresh healthy mitochondria. This will be achieved with a radical new therapeutic option: in-vivo mitochondrial transplantation. The MATRIX project has broad translational potential, including a new therapeutic approach to a clinically relevant condition, the development of technology for early diagnosis, and advances in knowledge of basic disease mechanisms.
Summary
Cardiac toxicity is one of the most frequent serious side effects of cancer therapy, affecting up to 30% of treated patients. Cancer treatment-induced cardiotoxicity (CTiCT) can result in severe heart failure. The trade-off between cancer and chronic heart failure is an immense personal burden with physical and psychological consequences. Current therapies for CTiCT are suboptimal, featuring poor early detection algorithms and nonspecific heart failure treatments. Based on our recently published results and additional preliminary data presented here, we propose that CTiCT is associated with altered mitochondrial dynamics, triggering a cardiomyocyte metabolic reprogramming. MATRIX represents a holistic approach to tackling mitochondrial dysfunction in CTiCT. Our hypothesis is that reverting metabolic reprogramming by shifting mitochondrial substrate utilization could represent a new paradigm in the treatment of early-stage CTiCT. By refining a novel imaging-based algorithm recently developed in our group, we will achieve very early detection of myocardial damage in patients treated with commonly prescribed cancer therapies, long before clinically used parameters become abnormal. Such early detection, not available currently, is crucial for implementation of early therapies. We also hypothesize that in end-stage CTiCT, mitochondrial dysfunction has passed a no-return point, and the failing heart will only be rescued by a strategy to replenish the myocardium with fresh healthy mitochondria. This will be achieved with a radical new therapeutic option: in-vivo mitochondrial transplantation. The MATRIX project has broad translational potential, including a new therapeutic approach to a clinically relevant condition, the development of technology for early diagnosis, and advances in knowledge of basic disease mechanisms.
Max ERC Funding
1 999 375 €
Duration
Start date: 2019-09-01, End date: 2024-08-31
Project acronym MOF-reactors
Project Metal-Organic Frameworks as Chemical Reactors for the Synthesis of Well-Defined Sub-Nanometer Metal Clusters
Researcher (PI) Emilio PARDO
Host Institution (HI) UNIVERSITAT DE VALENCIA
Call Details Consolidator Grant (CoG), PE5, ERC-2018-COG
Summary Humankind advancement is connected to the use and development of metal forms. Recent works have unveiled exceptional properties –such as luminescence, biocompatibility, antitumoral activity or a superlative catalytic activity– for small aggregations of metal atoms, so–called sub–nanometer metal clusters (SNMCs). Despite this importance, the gram-scale synthesis of structurally and electronically well–defined SNMCs is still far from being a reality.
The present proposal situates at the centre of such weakness and aims at making a breakthrough step-change on the use of metal-organic frameworks (MOFs) as chemical reactors for the in–situ synthesis of stable ligand-free SNMCs with such unique properties. This challenging synthetic strategy, which is assisted by striking published and inedited preliminary results, has solid foundations. Firstly, the design and large-scale preparation of cheap and novel families of highly robust and crystalline MOFs with tailor-made functional channels to be used as chemical reactors. Secondly, the application of solid-state post-synthetic methods to drive the multigram-scale preparation of unique ligand-free homo- and heterometallic SNMCs, which are, in the best-case scenario, very difficult to be obtained and stabilised outside the channels. Last but not least, single-crystal X-Ray diffraction will be used as the definitive tool for the characterisation, at the atomic level, of such ultrasmall species offering unprecedented snapshots about their real structures and formation mechanisms.
The ultimate goal will be upscaling this synthetic strategy aiming at the large-scale fabrication of SNMCs and their industrial application will be then evaluated. A successful achievement of all the aforementioned objectives of this ground-breaking project would open new routes for the use of MOFs as chemical reactors to manufacture, at competitive prices, MOF-driven, structurally and electronically well–defined, ligand–free SNMCs in a multigram-scale.
Summary
Humankind advancement is connected to the use and development of metal forms. Recent works have unveiled exceptional properties –such as luminescence, biocompatibility, antitumoral activity or a superlative catalytic activity– for small aggregations of metal atoms, so–called sub–nanometer metal clusters (SNMCs). Despite this importance, the gram-scale synthesis of structurally and electronically well–defined SNMCs is still far from being a reality.
The present proposal situates at the centre of such weakness and aims at making a breakthrough step-change on the use of metal-organic frameworks (MOFs) as chemical reactors for the in–situ synthesis of stable ligand-free SNMCs with such unique properties. This challenging synthetic strategy, which is assisted by striking published and inedited preliminary results, has solid foundations. Firstly, the design and large-scale preparation of cheap and novel families of highly robust and crystalline MOFs with tailor-made functional channels to be used as chemical reactors. Secondly, the application of solid-state post-synthetic methods to drive the multigram-scale preparation of unique ligand-free homo- and heterometallic SNMCs, which are, in the best-case scenario, very difficult to be obtained and stabilised outside the channels. Last but not least, single-crystal X-Ray diffraction will be used as the definitive tool for the characterisation, at the atomic level, of such ultrasmall species offering unprecedented snapshots about their real structures and formation mechanisms.
The ultimate goal will be upscaling this synthetic strategy aiming at the large-scale fabrication of SNMCs and their industrial application will be then evaluated. A successful achievement of all the aforementioned objectives of this ground-breaking project would open new routes for the use of MOFs as chemical reactors to manufacture, at competitive prices, MOF-driven, structurally and electronically well–defined, ligand–free SNMCs in a multigram-scale.
Max ERC Funding
1 886 000 €
Duration
Start date: 2019-03-01, End date: 2024-02-29
Project acronym ReadCalibration
Project Phonemic representations in speech perception and production: Recalibration by readingacquisition
Researcher (PI) Clara, Dominique, Sylvie Martin
Host Institution (HI) BCBL BASQUE CENTER ON COGNITION BRAIN AND LANGUAGE
Call Details Consolidator Grant (CoG), SH4, ERC-2018-COG
Summary The main goal of this project is to demonstrate that reading acquisition (RA) drastically reshapes our phonemic inventory, and to investigate the time-course and fine-grained properties of this recalibration. The main innovative and ground-breaking aspect of this project is the merging of two research fields, (1) reading acquisition and (2) phonemic recalibration, together with a deep and extensive exploration of the (3) perception-production link, which results in a new research line that pushes the boundaries of our understanding of the complex interactions between auditory and visual language perception and production.
We will demonstrate that phonemic representations (PRs) become more stable (less dispersed) during the process of learning to read, and that this recalibration varies according to the grapheme-phoneme conversion rules of the reading system. We will explore such recalibration by means of the first cross-linguistic longitudinal study examining the position and dispersion of PRs, both in perception and production of phonemes and words. Secondly, we will explore how recalibration develops when RA is impaired as is the case in dyslexic children –informing the research field on (4) dyslexia– and when pre-reading PRs are unstable as is the case in deaf children with cochlear implants –informing the research field on (5) deafness. Finally, the research will also be extended to PR recalibration during RA in a second language –informing the research on (6) bilingualism.
This proposal provides the first systematic investigation of phonemic recalibration during literacy acquisition, and will provide important insight for pragmatic research and theoretical accounts of language perception and production and phonemic recalibration. This project will also have major implications for the clinical field (theories and remediation of dyslexia and deafness) and for social policies and education (bilingualism, spoken and written language teaching).
Summary
The main goal of this project is to demonstrate that reading acquisition (RA) drastically reshapes our phonemic inventory, and to investigate the time-course and fine-grained properties of this recalibration. The main innovative and ground-breaking aspect of this project is the merging of two research fields, (1) reading acquisition and (2) phonemic recalibration, together with a deep and extensive exploration of the (3) perception-production link, which results in a new research line that pushes the boundaries of our understanding of the complex interactions between auditory and visual language perception and production.
We will demonstrate that phonemic representations (PRs) become more stable (less dispersed) during the process of learning to read, and that this recalibration varies according to the grapheme-phoneme conversion rules of the reading system. We will explore such recalibration by means of the first cross-linguistic longitudinal study examining the position and dispersion of PRs, both in perception and production of phonemes and words. Secondly, we will explore how recalibration develops when RA is impaired as is the case in dyslexic children –informing the research field on (4) dyslexia– and when pre-reading PRs are unstable as is the case in deaf children with cochlear implants –informing the research field on (5) deafness. Finally, the research will also be extended to PR recalibration during RA in a second language –informing the research on (6) bilingualism.
This proposal provides the first systematic investigation of phonemic recalibration during literacy acquisition, and will provide important insight for pragmatic research and theoretical accounts of language perception and production and phonemic recalibration. This project will also have major implications for the clinical field (theories and remediation of dyslexia and deafness) and for social policies and education (bilingualism, spoken and written language teaching).
Max ERC Funding
1 875 000 €
Duration
Start date: 2019-10-01, End date: 2024-09-30
Project acronym RememberEx
Project Human Subcortical-Cortical Circuit Dynamics for Remembering the Exceptional
Researcher (PI) Bryan STRANGE
Host Institution (HI) UNIVERSIDAD POLITECNICA DE MADRID
Call Details Consolidator Grant (CoG), LS5, ERC-2018-COG
Summary Our memory system is optimised for remembering the exceptional over the mundane. We remember better those events that violate predictions generated by the prevailing context, particularly because of surprise or emotional impact. Understanding how we form and retrieve long-term memories for important or salient events is critical for combating the rapidly growing incidence of pathologies associated with memory dysfunction with huge socio-econonomic burden. Human lesion and non-invasive functional imaging data, motivated by findings from animal models, have identified subcortical structures that are critical for upregulating hippocampal function during salient event memory. However, mechanistic understanding of these processes in humans remains scarce, and requires better experimental approaches such as direct intracranial recordings from, and focal electrical stimulation of, these subcortical structures.
This project will characterise human subcortico-cortical neuronal circuit dynamics associated with enhanced episodic memory for salient stimuli by studying direct recordings from human hippocampus, amygdala, nucleus accumbens, ventral midbrain and cortex. Within this framework, I will elucidate the electrophysiological mechanisms underlying amygdala-hippocampal-cortical coupling that lead to better memory for emotional stimuli, extend the hippocampal role in detecting unpredicted stimuli to define its role in orchestrating cortical dynamics in unpredictable contexts, and discover the neuronal response profile of the human mesolimbic dopamine system during salient stimulus encoding. The predicted results, based on my own preliminary data, will offer several conceptual breakthroughs, particularly regarding hippocampal function and the role of dopaminergic ventral midbrain in memory. The knowledge gained from this project is a fundamental requirement for designing therapeutic interventions for patients with memory deficits and other neuropsychiatric disorders.
Summary
Our memory system is optimised for remembering the exceptional over the mundane. We remember better those events that violate predictions generated by the prevailing context, particularly because of surprise or emotional impact. Understanding how we form and retrieve long-term memories for important or salient events is critical for combating the rapidly growing incidence of pathologies associated with memory dysfunction with huge socio-econonomic burden. Human lesion and non-invasive functional imaging data, motivated by findings from animal models, have identified subcortical structures that are critical for upregulating hippocampal function during salient event memory. However, mechanistic understanding of these processes in humans remains scarce, and requires better experimental approaches such as direct intracranial recordings from, and focal electrical stimulation of, these subcortical structures.
This project will characterise human subcortico-cortical neuronal circuit dynamics associated with enhanced episodic memory for salient stimuli by studying direct recordings from human hippocampus, amygdala, nucleus accumbens, ventral midbrain and cortex. Within this framework, I will elucidate the electrophysiological mechanisms underlying amygdala-hippocampal-cortical coupling that lead to better memory for emotional stimuli, extend the hippocampal role in detecting unpredicted stimuli to define its role in orchestrating cortical dynamics in unpredictable contexts, and discover the neuronal response profile of the human mesolimbic dopamine system during salient stimulus encoding. The predicted results, based on my own preliminary data, will offer several conceptual breakthroughs, particularly regarding hippocampal function and the role of dopaminergic ventral midbrain in memory. The knowledge gained from this project is a fundamental requirement for designing therapeutic interventions for patients with memory deficits and other neuropsychiatric disorders.
Max ERC Funding
2 000 000 €
Duration
Start date: 2019-05-01, End date: 2024-04-30
Project acronym SUBSILIENCE
Project Subsistence and human resilience to sudden climatic events in Europe during MIS3
Researcher (PI) ANA B. MARIN-ARROYO
Host Institution (HI) UNIVERSIDAD DE CANTABRIA
Call Details Consolidator Grant (CoG), SH6, ERC-2018-COG
Summary Climate has long been proposed as a possible trigger-factor for the extinction of Neanderthals and the rapid colonization of Europe by Anatomically Modern Humans (AMH). Abrupt and acute oscillations of climate, as recorded from polar ice sheets, are particularly threatening as they can push ecosystems towards catastrophic outcomes. Under these conditions, the survival of a species critically depends on their adaptive skills. Understanding the exact role that these episodes could have had in the Middle to Upper Palaeolithic transition is then essential to unravel the real causes of Neanderthal demise and AMH success. To do this, SUBSILIENCE will identify the subsistence strategies adopted by both human species in response to those climatic changes at 20 key archaeological sites located across southern European peninsulas. By applying zooarchaeological and taphonomic analyses, the behavioural flexibility and resilience of each human species will be assessed. In addition, to enable effective testing, local terrestrial climatic and environmental conditions will be accurately reconstructed using stable isotopes from animals consumed, producing a unique, continuous and properly-dated general environmental framework, improving existing knowledge. Finally, to further explore the problem, an innovative procedure to estimate prey abundance, ecology and human behaviour, involving the estimation of the ecosystem carrying capacity, will be developed. This multidisciplinary and novel approach will provide, for the first time, accurate answers to questions concerning a) which particular subsistence patterns (if any) favoured AMH over Neanderthals while coping with the changing environment and b) the extent to which climatic oscillations affected Neanderthal extinction. In this, it will be of relevance to the study of Prehistory on a pan-European scale.
Summary
Climate has long been proposed as a possible trigger-factor for the extinction of Neanderthals and the rapid colonization of Europe by Anatomically Modern Humans (AMH). Abrupt and acute oscillations of climate, as recorded from polar ice sheets, are particularly threatening as they can push ecosystems towards catastrophic outcomes. Under these conditions, the survival of a species critically depends on their adaptive skills. Understanding the exact role that these episodes could have had in the Middle to Upper Palaeolithic transition is then essential to unravel the real causes of Neanderthal demise and AMH success. To do this, SUBSILIENCE will identify the subsistence strategies adopted by both human species in response to those climatic changes at 20 key archaeological sites located across southern European peninsulas. By applying zooarchaeological and taphonomic analyses, the behavioural flexibility and resilience of each human species will be assessed. In addition, to enable effective testing, local terrestrial climatic and environmental conditions will be accurately reconstructed using stable isotopes from animals consumed, producing a unique, continuous and properly-dated general environmental framework, improving existing knowledge. Finally, to further explore the problem, an innovative procedure to estimate prey abundance, ecology and human behaviour, involving the estimation of the ecosystem carrying capacity, will be developed. This multidisciplinary and novel approach will provide, for the first time, accurate answers to questions concerning a) which particular subsistence patterns (if any) favoured AMH over Neanderthals while coping with the changing environment and b) the extent to which climatic oscillations affected Neanderthal extinction. In this, it will be of relevance to the study of Prehistory on a pan-European scale.
Max ERC Funding
2 000 000 €
Duration
Start date: 2019-06-01, End date: 2024-05-31
Project acronym TRADITION
Project Long-term coastal adaptation, food security and poverty alleviation in Latin America
Researcher (PI) Andre Carlo COLONESE
Host Institution (HI) UNIVERSITAT AUTONOMA DE BARCELONA
Call Details Consolidator Grant (CoG), SH6, ERC-2018-COG
Summary TRADITION aims to understand the long-term trajectory of human interaction with coastal resources and its legacy to present day small-scale fisheries in Latin America. Founded on traditional knowledge rooted in the past, small-scale fisheries are a crucial source of food and livelihood for millions of people worldwide, and play a pivotal role in poverty eradication in developing countries. A thorough recognition of the cultural and socio-economic significance of Latin American fisheries requires a temporal component that only archaeology and history can provide. TRADITION will investigate a 4000-year record of coastal exploitation in one of the world's most threatened tropical environments: the Atlantic forest of Brazil. We will draw together archaeological, palaeoecological, historical and ethnographic records to address fundamental questions that impinge upon our current understanding of the development of small-scale fisheries in this region. How did coastal economies adapt to the spread of agriculture? What was the impact of past climate and environmental changes on coastal populations? What was the impact of European colonisation of the Americas on the development of small-scale fisheries? What was the role of historical institutions and regulations in the negotiation between traditional and modern practices in small-scale fisheries? How have the historical practices and events shaped current small-scale coastal communities, and can this knowledge benefit current management strategies. The answers will help us understand how coastal economies responded to unprecedented societal and environmental changes by adapting their subsistence practices, technology and culture, while contributing to the foundation of coastal societies in Latin America.
Summary
TRADITION aims to understand the long-term trajectory of human interaction with coastal resources and its legacy to present day small-scale fisheries in Latin America. Founded on traditional knowledge rooted in the past, small-scale fisheries are a crucial source of food and livelihood for millions of people worldwide, and play a pivotal role in poverty eradication in developing countries. A thorough recognition of the cultural and socio-economic significance of Latin American fisheries requires a temporal component that only archaeology and history can provide. TRADITION will investigate a 4000-year record of coastal exploitation in one of the world's most threatened tropical environments: the Atlantic forest of Brazil. We will draw together archaeological, palaeoecological, historical and ethnographic records to address fundamental questions that impinge upon our current understanding of the development of small-scale fisheries in this region. How did coastal economies adapt to the spread of agriculture? What was the impact of past climate and environmental changes on coastal populations? What was the impact of European colonisation of the Americas on the development of small-scale fisheries? What was the role of historical institutions and regulations in the negotiation between traditional and modern practices in small-scale fisheries? How have the historical practices and events shaped current small-scale coastal communities, and can this knowledge benefit current management strategies. The answers will help us understand how coastal economies responded to unprecedented societal and environmental changes by adapting their subsistence practices, technology and culture, while contributing to the foundation of coastal societies in Latin America.
Max ERC Funding
1 877 107 €
Duration
Start date: 2019-09-01, End date: 2024-08-31
Project acronym UpTEMPO
Project Ultrafast tunneling microscopy by optical field control of quantum currents
Researcher (PI) Daniele BRIDA
Host Institution (HI) UNIVERSITE DU LUXEMBOURG
Call Details Consolidator Grant (CoG), PE2, ERC-2018-COG
Summary The project aims at imaging electronic dynamics in molecules with atomic precision and sub-femtosecond temporal resolution. This result will be achieved by establishing new experiments at the boundary of ultrafast optics and scanning probe microscopy where the electric field of single-cycle light pulses is harnessed to control currents in nanojunctions. The basic concept relies on the fact that state-of-the-art femtosecond optical wave packets exhibit only one cycle of radiation with a defined electric field maximum. These pulses need to be phase locked to a “cosine-like” electric field profile. If such radiation is focused onto a junction with a nonlinear current-voltage characteristics, a net charge flow results solely due to the bias induced by the optical field.
In detail, we want to exploit the time resolution provided by this new technique and induce electron transport at the probe tip of a scanning tunneling microscope (STM). The optical control of the current over a sub-optical-cycle interval will guarantee a temporal resolution better that one femtosecond, thus improving by several orders of magnitude what can be achieved with standard electronic bias.
The core of the experimental system will be an ultrabroadband and passively phase-locked Er:fiber laser that is designed to generate single-cycle optical pulses in the near/mid-infrared, i.e. off resonant to the transition energies of III-V and II-VI semiconductors and large molecules. This laser will operate at 80-MHz repetition rate for enhanced sensitivity and stability when coupled to an ultra-high-vacuum STM. The setup will allow for the direct combination of independent pulse trains to resonantly excite few-femtosecond dynamics and then probe the electron density via the optically driven tunneling. In this pump-probe scheme it will be possible to map with atomic resolution the coherent evolution of electronic wavefunctions that in molecules and nanosystems follows an impulsive photoexcitation.
Summary
The project aims at imaging electronic dynamics in molecules with atomic precision and sub-femtosecond temporal resolution. This result will be achieved by establishing new experiments at the boundary of ultrafast optics and scanning probe microscopy where the electric field of single-cycle light pulses is harnessed to control currents in nanojunctions. The basic concept relies on the fact that state-of-the-art femtosecond optical wave packets exhibit only one cycle of radiation with a defined electric field maximum. These pulses need to be phase locked to a “cosine-like” electric field profile. If such radiation is focused onto a junction with a nonlinear current-voltage characteristics, a net charge flow results solely due to the bias induced by the optical field.
In detail, we want to exploit the time resolution provided by this new technique and induce electron transport at the probe tip of a scanning tunneling microscope (STM). The optical control of the current over a sub-optical-cycle interval will guarantee a temporal resolution better that one femtosecond, thus improving by several orders of magnitude what can be achieved with standard electronic bias.
The core of the experimental system will be an ultrabroadband and passively phase-locked Er:fiber laser that is designed to generate single-cycle optical pulses in the near/mid-infrared, i.e. off resonant to the transition energies of III-V and II-VI semiconductors and large molecules. This laser will operate at 80-MHz repetition rate for enhanced sensitivity and stability when coupled to an ultra-high-vacuum STM. The setup will allow for the direct combination of independent pulse trains to resonantly excite few-femtosecond dynamics and then probe the electron density via the optically driven tunneling. In this pump-probe scheme it will be possible to map with atomic resolution the coherent evolution of electronic wavefunctions that in molecules and nanosystems follows an impulsive photoexcitation.
Max ERC Funding
1 999 509 €
Duration
Start date: 2019-09-01, End date: 2024-08-31
Project acronym URBAG
Project Integrated System Analysis of Urban Vegetation and Agriculture
Researcher (PI) Gara Villalba Méndez
Host Institution (HI) UNIVERSITAT AUTONOMA DE BARCELONA
Call Details Consolidator Grant (CoG), SH2, ERC-2018-COG
Summary This research aims to find out how urban green infrastructures can be most efficient in contributing to urban sustainability. This will evaluate which combinations of urban, peri-urban agriculture and green spaces result in the best performance in terms of local and global environmental impact.
For this purpose, I will use novel and comprehensive analysis that will integrate the life cycle impacts of the resources required for green infrastructures with the understanding of how green infrastructures impact the urban atmosphere interaction. This comprehensive approach allows to capture the urban metabolism to optimize the food-energy-water nexus. In previous works, the impacts had been only studied individually.
The analysis will consist of 1) A geo-referenced land-use model to optimize urban and peri-urban food production in terms of nutrients, water, and energy, considering urban morphology and determining life cycle impacts 2) A spatially-temporally resolved framework for quantitative analysis and simulation of green infrastructures to determine the direct and indirect effects on the urban and regional atmosphere. The research will be implemented in two selected cities with different profiles, Barcelona and Oslo. The study ambitions to gather substantial quantitative evidence in green infrastructures and sustainability, contributing to cover the existing gap in previous works.
This project and the envisaged: Green infrastructures - A Guide for city planners and policy makers, are timely and urgent. Many cities are implementing green infrastructures despite having little quantitative and comprehensive knowledge as to which infrastructure strategies are more effective in promoting food production, air quality and temperature while reducing environmental impact. This intended Guide will contain evidence-based guidance and tools to create green infrastructure strategies; to help to meet sustainability targets, and promote wider and diffused social benefits.
Summary
This research aims to find out how urban green infrastructures can be most efficient in contributing to urban sustainability. This will evaluate which combinations of urban, peri-urban agriculture and green spaces result in the best performance in terms of local and global environmental impact.
For this purpose, I will use novel and comprehensive analysis that will integrate the life cycle impacts of the resources required for green infrastructures with the understanding of how green infrastructures impact the urban atmosphere interaction. This comprehensive approach allows to capture the urban metabolism to optimize the food-energy-water nexus. In previous works, the impacts had been only studied individually.
The analysis will consist of 1) A geo-referenced land-use model to optimize urban and peri-urban food production in terms of nutrients, water, and energy, considering urban morphology and determining life cycle impacts 2) A spatially-temporally resolved framework for quantitative analysis and simulation of green infrastructures to determine the direct and indirect effects on the urban and regional atmosphere. The research will be implemented in two selected cities with different profiles, Barcelona and Oslo. The study ambitions to gather substantial quantitative evidence in green infrastructures and sustainability, contributing to cover the existing gap in previous works.
This project and the envisaged: Green infrastructures - A Guide for city planners and policy makers, are timely and urgent. Many cities are implementing green infrastructures despite having little quantitative and comprehensive knowledge as to which infrastructure strategies are more effective in promoting food production, air quality and temperature while reducing environmental impact. This intended Guide will contain evidence-based guidance and tools to create green infrastructure strategies; to help to meet sustainability targets, and promote wider and diffused social benefits.
Max ERC Funding
1 893 754 €
Duration
Start date: 2019-09-01, End date: 2024-08-31
Project acronym ViroPedTher
Project Oncolytic viruses for the treatment of pediatric brain tumors: An integrated clinical and lab approach
Researcher (PI) marta ALONSO-ROLDAN
Host Institution (HI) UNIVERSIDAD DE NAVARRA
Call Details Consolidator Grant (CoG), LS7, ERC-2018-COG
Summary The overreaching goal of my lab is to improve the prognosis of patients with high-risk pediatric brain tumors. To this end, I propose to integrate clinical and lab-based research to develop tumor-targeted oncolytic adenoviruses with the capacity to elicit a therapeutic immune response in those tumors. Our research will use novel and relevant models to accomplish the experimental aims. We have previously worked with Delta-24-RGD (DNX-2401) a replication-competent adenovirus that has been translated to the clinical scenario. In 2017, the first clinical trial phase I with DNX-2401 for newly diagnosed Diffuse Intrinsic Pontine Gliomas (DIPG; a lethal pediatric brain tumor) opened propelled by my team. Preliminary results from the first trials revealed that the intratumoral injection of the virus instigated an initial phase of oncolysis followed by a delayed inflammatory response that ultimately resulted in complete regression in a subset of the patients without associated toxicities. I hypothesized that enhancement of the immune component of the DNX-2401-based therapy will result in the complete regression of the vast majority of pediatric brain tumors. In our specific approach, we propose to understand the immune microenvironment of DIPGs and the response to viral therapy in the context of the trial. Moreover, that knowledge will leverage the design of Delta-24-based adenoviruses to recruit lymphocytes to the tumor with the competence of different type of ligands to activate the tumor infiltrating lymphocytes. I expect that this combinatorial innovative treatment will efficiently challenge the profound and inherent tumor immunosuppression and, in turn, will elicit a robust anti-tumor immune response resulting in the significant improvement of the prognosis and quality of life of patients with pediatric brain tumors. This project has the potential to produce a vertical advance in the field of pediatric oncology.
Summary
The overreaching goal of my lab is to improve the prognosis of patients with high-risk pediatric brain tumors. To this end, I propose to integrate clinical and lab-based research to develop tumor-targeted oncolytic adenoviruses with the capacity to elicit a therapeutic immune response in those tumors. Our research will use novel and relevant models to accomplish the experimental aims. We have previously worked with Delta-24-RGD (DNX-2401) a replication-competent adenovirus that has been translated to the clinical scenario. In 2017, the first clinical trial phase I with DNX-2401 for newly diagnosed Diffuse Intrinsic Pontine Gliomas (DIPG; a lethal pediatric brain tumor) opened propelled by my team. Preliminary results from the first trials revealed that the intratumoral injection of the virus instigated an initial phase of oncolysis followed by a delayed inflammatory response that ultimately resulted in complete regression in a subset of the patients without associated toxicities. I hypothesized that enhancement of the immune component of the DNX-2401-based therapy will result in the complete regression of the vast majority of pediatric brain tumors. In our specific approach, we propose to understand the immune microenvironment of DIPGs and the response to viral therapy in the context of the trial. Moreover, that knowledge will leverage the design of Delta-24-based adenoviruses to recruit lymphocytes to the tumor with the competence of different type of ligands to activate the tumor infiltrating lymphocytes. I expect that this combinatorial innovative treatment will efficiently challenge the profound and inherent tumor immunosuppression and, in turn, will elicit a robust anti-tumor immune response resulting in the significant improvement of the prognosis and quality of life of patients with pediatric brain tumors. This project has the potential to produce a vertical advance in the field of pediatric oncology.
Max ERC Funding
2 000 000 €
Duration
Start date: 2019-03-01, End date: 2024-02-29