Project acronym 2SEXES_1GENOME
Project Sex-specific genetic effects on fitness and human disease
Researcher (PI) Edward Hugh Morrow
Host Institution (HI) THE UNIVERSITY OF SUSSEX
Call Details Starting Grant (StG), LS8, ERC-2011-StG_20101109
Summary Darwin’s theory of natural selection rests on the principle that fitness variation in natural populations has a heritable component, on which selection acts, thereby leading to evolutionary change. A fundamental and so far unresolved question for the field of evolutionary biology is to identify the genetic loci responsible for this fitness variation, thereby coming closer to an understanding of how variation is maintained in the face of continual selection. One important complicating factor in the search for fitness related genes however is the existence of separate sexes – theoretical expectations and empirical data both suggest that sexually antagonistic genes are common. The phrase “two sexes, one genome” nicely sums up the problem; selection may favour alleles in one sex, even if they have detrimental effects on the fitness of the opposite sex, since it is their net effect across both sexes that determine the likelihood that alleles persist in a population. This theoretical framework raises an interesting, and so far entirely unexplored issue: that in one sex the functional performance of some alleles is predicted to be compromised and this effect may account for some common human diseases and conditions which show genotype-sex interactions. I propose to explore the genetic basis of sex-specific fitness in a model organism in both laboratory and natural conditions and to test whether those genes identified as having sexually antagonistic effects can help explain the incidence of human diseases that display sexual dimorphism in prevalence, age of onset or severity. This multidisciplinary project directly addresses some fundamental unresolved questions in evolutionary biology: the genetic basis and maintenance of fitness variation; the evolution of sexual dimorphism; and aims to provide novel insights into the genetic basis of some common human diseases.
Summary
Darwin’s theory of natural selection rests on the principle that fitness variation in natural populations has a heritable component, on which selection acts, thereby leading to evolutionary change. A fundamental and so far unresolved question for the field of evolutionary biology is to identify the genetic loci responsible for this fitness variation, thereby coming closer to an understanding of how variation is maintained in the face of continual selection. One important complicating factor in the search for fitness related genes however is the existence of separate sexes – theoretical expectations and empirical data both suggest that sexually antagonistic genes are common. The phrase “two sexes, one genome” nicely sums up the problem; selection may favour alleles in one sex, even if they have detrimental effects on the fitness of the opposite sex, since it is their net effect across both sexes that determine the likelihood that alleles persist in a population. This theoretical framework raises an interesting, and so far entirely unexplored issue: that in one sex the functional performance of some alleles is predicted to be compromised and this effect may account for some common human diseases and conditions which show genotype-sex interactions. I propose to explore the genetic basis of sex-specific fitness in a model organism in both laboratory and natural conditions and to test whether those genes identified as having sexually antagonistic effects can help explain the incidence of human diseases that display sexual dimorphism in prevalence, age of onset or severity. This multidisciplinary project directly addresses some fundamental unresolved questions in evolutionary biology: the genetic basis and maintenance of fitness variation; the evolution of sexual dimorphism; and aims to provide novel insights into the genetic basis of some common human diseases.
Max ERC Funding
1 500 000 €
Duration
Start date: 2012-01-01, End date: 2016-12-31
Project acronym ABYSS
Project ABYSS - Assessment of bacterial life and matter cycling in deep-sea surface sediments
Researcher (PI) Antje Boetius
Host Institution (HI) ALFRED-WEGENER-INSTITUT HELMHOLTZ-ZENTRUM FUR POLAR- UND MEERESFORSCHUNG
Call Details Advanced Grant (AdG), LS8, ERC-2011-ADG_20110310
Summary The deep-sea floor hosts a distinct microbial biome covering 67% of the Earth’s surface, characterized by cold temperatures, permanent darkness, high pressure and food limitation. The surface sediments are dominated by bacteria, with on average a billion cells per ml. Benthic bacteria are highly relevant to the Earth’s element cycles as they remineralize most of the organic matter sinking from the productive surface ocean, and return nutrients, thereby promoting ocean primary production. What passes the bacterial filter is a relevant sink for carbon on geological time scales, influencing global oxygen and carbon budgets, and fueling the deep subsurface biosphere. Despite the relevance of deep-sea sediment bacteria to climate, geochemical cycles and ecology of the seafloor, their genetic and functional diversity, niche differentiation and biological interactions remain unknown. Our preliminary work in a global survey of deep-sea sediments enables us now to target specific genes for the quantification of abyssal bacteria. We can trace isotope-labeled elements into communities and single cells, and analyze the molecular alteration of organic matter during microbial degradation, all in context with environmental dynamics recorded at the only long-term deep-sea ecosystem observatory in the Arctic that we maintain. I propose to bridge biogeochemistry, ecology, microbiology and marine biology to develop a systematic understanding of abyssal sediment bacterial community distribution, diversity, function and interactions, by combining in situ flux studies and different visualization techniques with a wide range of molecular tools. Substantial progress is expected in understanding I) identity and function of the dominant types of indigenous benthic bacteria, II) dynamics in bacterial activity and diversity caused by variations in particle flux, III) interactions with different types and ages of organic matter, and other biological factors.
Summary
The deep-sea floor hosts a distinct microbial biome covering 67% of the Earth’s surface, characterized by cold temperatures, permanent darkness, high pressure and food limitation. The surface sediments are dominated by bacteria, with on average a billion cells per ml. Benthic bacteria are highly relevant to the Earth’s element cycles as they remineralize most of the organic matter sinking from the productive surface ocean, and return nutrients, thereby promoting ocean primary production. What passes the bacterial filter is a relevant sink for carbon on geological time scales, influencing global oxygen and carbon budgets, and fueling the deep subsurface biosphere. Despite the relevance of deep-sea sediment bacteria to climate, geochemical cycles and ecology of the seafloor, their genetic and functional diversity, niche differentiation and biological interactions remain unknown. Our preliminary work in a global survey of deep-sea sediments enables us now to target specific genes for the quantification of abyssal bacteria. We can trace isotope-labeled elements into communities and single cells, and analyze the molecular alteration of organic matter during microbial degradation, all in context with environmental dynamics recorded at the only long-term deep-sea ecosystem observatory in the Arctic that we maintain. I propose to bridge biogeochemistry, ecology, microbiology and marine biology to develop a systematic understanding of abyssal sediment bacterial community distribution, diversity, function and interactions, by combining in situ flux studies and different visualization techniques with a wide range of molecular tools. Substantial progress is expected in understanding I) identity and function of the dominant types of indigenous benthic bacteria, II) dynamics in bacterial activity and diversity caused by variations in particle flux, III) interactions with different types and ages of organic matter, and other biological factors.
Max ERC Funding
3 375 693 €
Duration
Start date: 2012-06-01, End date: 2018-05-31
Project acronym ADULT
Project Analysis of the Dark Universe through Lensing Tomography
Researcher (PI) Hendrik Hoekstra
Host Institution (HI) UNIVERSITEIT LEIDEN
Call Details Starting Grant (StG), PE9, ERC-2011-StG_20101014
Summary The discoveries that the expansion of the universe is accelerating due to an unknown “dark energy”
and that most of the matter is invisible, highlight our lack of understanding of the major constituents
of the universe. These surprising findings set the stage for research in cosmology at the start of the
21st century. The objective of this proposal is to advance observational constraints to a level where we can distinguish between physical mechanisms that aim to explain the properties of dark energy and the observed distribution of dark matter throughout the universe. We use a relatively new technique called weak gravitational lensing: the accurate measurement of correlations in the orientations of distant galaxies enables us to map the dark matter distribution directly and to extract the cosmological information that is encoded by the large-scale structure.
To study the dark universe we will analyse data from a new state-of-the-art imaging survey: the Kilo-
Degree Survey (KiDS) will cover 1500 square degrees in 9 filters. The combination of its large survey
area and the availability of exquisite photometric redshifts for the sources makes KiDS the first
project that can place interesting constraints on the dark energy equation-of-state using lensing data
alone. Combined with complementary results from Planck, our measurements will provide one of the
best views of the dark side of the universe before much larger space-based projects commence.
To reach the desired accuracy we need to carefully measure the shapes of distant background galaxies. We also need to account for any intrinsic alignments that arise due to tidal interactions, rather than through lensing. Reducing these observational and physical biases to negligible levels is a necessarystep to ensure the success of KiDS and an important part of our preparation for more challenging projects such as the European-led space mission Euclid.
Summary
The discoveries that the expansion of the universe is accelerating due to an unknown “dark energy”
and that most of the matter is invisible, highlight our lack of understanding of the major constituents
of the universe. These surprising findings set the stage for research in cosmology at the start of the
21st century. The objective of this proposal is to advance observational constraints to a level where we can distinguish between physical mechanisms that aim to explain the properties of dark energy and the observed distribution of dark matter throughout the universe. We use a relatively new technique called weak gravitational lensing: the accurate measurement of correlations in the orientations of distant galaxies enables us to map the dark matter distribution directly and to extract the cosmological information that is encoded by the large-scale structure.
To study the dark universe we will analyse data from a new state-of-the-art imaging survey: the Kilo-
Degree Survey (KiDS) will cover 1500 square degrees in 9 filters. The combination of its large survey
area and the availability of exquisite photometric redshifts for the sources makes KiDS the first
project that can place interesting constraints on the dark energy equation-of-state using lensing data
alone. Combined with complementary results from Planck, our measurements will provide one of the
best views of the dark side of the universe before much larger space-based projects commence.
To reach the desired accuracy we need to carefully measure the shapes of distant background galaxies. We also need to account for any intrinsic alignments that arise due to tidal interactions, rather than through lensing. Reducing these observational and physical biases to negligible levels is a necessarystep to ensure the success of KiDS and an important part of our preparation for more challenging projects such as the European-led space mission Euclid.
Max ERC Funding
1 316 880 €
Duration
Start date: 2012-01-01, End date: 2016-12-31
Project acronym ARISE
Project The Ecology of Antibiotic Resistance
Researcher (PI) Roy Kishony
Host Institution (HI) TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY
Call Details Starting Grant (StG), LS8, ERC-2011-StG_20101109
Summary Main goal. We aim to understand the puzzling coexistence of antibiotic-resistant and antibiotic-sensitive species in natural soil environments, using novel quantitative experimental techniques and mathematical analysis. The ecological insights gained will be translated into novel treatment strategies for combating antibiotic resistance.
Background. Microbial soil ecosystems comprise communities of species interacting through copious secretion of antibiotics and other chemicals. Defence mechanisms, i.e. resistance to antibiotics, are ubiquitous in these wild communities. However, in sharp contrast to clinical settings, resistance does not take over the population. Our hypothesis is that the ecological setting provides natural mechanisms that keep antibiotic resistance in check. We are motivated by our recent finding that specific antibiotic combinations can generate selection against resistance and that soil microbial strains produce compounds that directly target antibiotic resistant mechanisms.
Approaches. We will: (1) Isolate natural bacterial species from individual grains of soil, characterize their ability to produce and resist antibiotics and identify the spatial scale for correlations between resistance and production. (2) Systematically measure interactions between species and identify interaction patterns enriched in co-existing communities derived from the same grain of soil. (3) Introducing fluorescently-labelled resistant and sensitive strains into natural soil, we will measure the fitness cost and benefit of antibiotic resistance in situ and identify natural compounds that select against resistance. (4) Test whether such “selection-inverting” compounds can slow evolution of resistance to antibiotics in continuous culture experiments.
Conclusions. These findings will provide insights into the ecological processes that keep antibiotic resistance in check, and will suggest novel antimicrobial treatment strategies.
Summary
Main goal. We aim to understand the puzzling coexistence of antibiotic-resistant and antibiotic-sensitive species in natural soil environments, using novel quantitative experimental techniques and mathematical analysis. The ecological insights gained will be translated into novel treatment strategies for combating antibiotic resistance.
Background. Microbial soil ecosystems comprise communities of species interacting through copious secretion of antibiotics and other chemicals. Defence mechanisms, i.e. resistance to antibiotics, are ubiquitous in these wild communities. However, in sharp contrast to clinical settings, resistance does not take over the population. Our hypothesis is that the ecological setting provides natural mechanisms that keep antibiotic resistance in check. We are motivated by our recent finding that specific antibiotic combinations can generate selection against resistance and that soil microbial strains produce compounds that directly target antibiotic resistant mechanisms.
Approaches. We will: (1) Isolate natural bacterial species from individual grains of soil, characterize their ability to produce and resist antibiotics and identify the spatial scale for correlations between resistance and production. (2) Systematically measure interactions between species and identify interaction patterns enriched in co-existing communities derived from the same grain of soil. (3) Introducing fluorescently-labelled resistant and sensitive strains into natural soil, we will measure the fitness cost and benefit of antibiotic resistance in situ and identify natural compounds that select against resistance. (4) Test whether such “selection-inverting” compounds can slow evolution of resistance to antibiotics in continuous culture experiments.
Conclusions. These findings will provide insights into the ecological processes that keep antibiotic resistance in check, and will suggest novel antimicrobial treatment strategies.
Max ERC Funding
1 900 000 €
Duration
Start date: 2012-09-01, End date: 2018-08-31
Project acronym Beacon
Project Beacons in the Dark
Researcher (PI) Paulo César Carvalho Freire
Host Institution (HI) MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Call Details Starting Grant (StG), PE9, ERC-2011-StG_20101014
Summary BEACON aims at performing an ambitious multi-disciplinary (optical, radio astronomy and theoretical physics) study to enable a fundamentally improved understanding of gravitation and space-time. For almost a century Einstein's general relativity has been the last word on gravity. However, superstring theory predicts new gravitational phenomena beyond relativity. In this proposal I will attempt to detect these new phenomena, with a sensitivity 20 times better than state-of-the-art attempts. A successful detection would take physics beyond its current understanding of the Universe.
These new gravitational phenomena are emission of dipolar gravitational waves and the violation of the strong equivalence principle (SEP). I plan to look for them by timing newly discovered binary pulsars. I will improve upon the best current limits on dipolar gravitational wave emission by a factor of 20 within the time of this proposal. I also plan to develop a test of the Strong Equivalence Principle using a new pulsar/main-sequence star binary. The precision of this test is likely to surpass the current best limits within the time frame of this proposal and then keep improving indefinitely with time. This happens because this is the cleanest gravitational experiment ever carried out.
In order to further these goals, I plan to build the ultimate pulsar observing system. By taking advantage of recent technological advances in microwave engineering (particularly sensitive ultra-wide band receivers) digital electronics (fast analogue-to-digital converters and digital spectrometers) and computing, my team and me will be able to greatly improve the sensitivity and precision for pulsar timing experiments and exploit the capabilities of modern radio telescopes to their limits.
Pulsars are the beacons that will guide me in these new, uncharted seas.
Summary
BEACON aims at performing an ambitious multi-disciplinary (optical, radio astronomy and theoretical physics) study to enable a fundamentally improved understanding of gravitation and space-time. For almost a century Einstein's general relativity has been the last word on gravity. However, superstring theory predicts new gravitational phenomena beyond relativity. In this proposal I will attempt to detect these new phenomena, with a sensitivity 20 times better than state-of-the-art attempts. A successful detection would take physics beyond its current understanding of the Universe.
These new gravitational phenomena are emission of dipolar gravitational waves and the violation of the strong equivalence principle (SEP). I plan to look for them by timing newly discovered binary pulsars. I will improve upon the best current limits on dipolar gravitational wave emission by a factor of 20 within the time of this proposal. I also plan to develop a test of the Strong Equivalence Principle using a new pulsar/main-sequence star binary. The precision of this test is likely to surpass the current best limits within the time frame of this proposal and then keep improving indefinitely with time. This happens because this is the cleanest gravitational experiment ever carried out.
In order to further these goals, I plan to build the ultimate pulsar observing system. By taking advantage of recent technological advances in microwave engineering (particularly sensitive ultra-wide band receivers) digital electronics (fast analogue-to-digital converters and digital spectrometers) and computing, my team and me will be able to greatly improve the sensitivity and precision for pulsar timing experiments and exploit the capabilities of modern radio telescopes to their limits.
Pulsars are the beacons that will guide me in these new, uncharted seas.
Max ERC Funding
1 892 376 €
Duration
Start date: 2011-09-01, End date: 2016-08-31
Project acronym BEAMING
Project Detecting massive-planet/brown-dwarf/low-mass-stellar companions with the beaming effect
Researcher (PI) Moshe Zvi Mazeh
Host Institution (HI) TEL AVIV UNIVERSITY
Call Details Advanced Grant (AdG), PE9, ERC-2011-ADG_20110209
Summary "I propose to lead an international observational effort to characterize the population of massive planets, brown dwarf and stellar secondaries orbiting their parent stars with short periods, up to 10-30 days. The effort will utilize the superb, accurate, continuous lightcurves of more than hundred thousand stars obtained recently by two space missions – CoRoT and Kepler. I propose to use these lightcurves to detect non-transiting low-mass companions with a new algorithm, BEER, which I developed recently together with Simchon Faigler. BEER searches for the beaming effect, which causes the stellar intensity to increase if the star is moving towards the observer. The combination of the beaming effect with other modulations induced by a low-mass companion produces periodic modulation with a specific signature, which is used to detect small non-transiting companions. The accuracy of the space mission lightcurves is enough to detect massive planets with short periods. The proposed project is equivalent to a radial-velocity survey of tens of thousands of stars, instead of the presently active surveys which observe only hundreds of stars.
We will use an assortment of telescopes to perform radial velocity follow-up observations in order to confirm the existence of the detected companions, and to derive their masses and orbital eccentricities. We will discover many tens, if not hundreds, of new massive planets and brown dwarfs with short periods, and many thousands of new binaries. The findings will enable us to map the mass, period, and eccentricity distributions of planets and stellar companions, determine the upper mass of planets, understand the nature of the brown-dwarf desert, and put strong constrains on the theory of planet and binary formation and evolution."
Summary
"I propose to lead an international observational effort to characterize the population of massive planets, brown dwarf and stellar secondaries orbiting their parent stars with short periods, up to 10-30 days. The effort will utilize the superb, accurate, continuous lightcurves of more than hundred thousand stars obtained recently by two space missions – CoRoT and Kepler. I propose to use these lightcurves to detect non-transiting low-mass companions with a new algorithm, BEER, which I developed recently together with Simchon Faigler. BEER searches for the beaming effect, which causes the stellar intensity to increase if the star is moving towards the observer. The combination of the beaming effect with other modulations induced by a low-mass companion produces periodic modulation with a specific signature, which is used to detect small non-transiting companions. The accuracy of the space mission lightcurves is enough to detect massive planets with short periods. The proposed project is equivalent to a radial-velocity survey of tens of thousands of stars, instead of the presently active surveys which observe only hundreds of stars.
We will use an assortment of telescopes to perform radial velocity follow-up observations in order to confirm the existence of the detected companions, and to derive their masses and orbital eccentricities. We will discover many tens, if not hundreds, of new massive planets and brown dwarfs with short periods, and many thousands of new binaries. The findings will enable us to map the mass, period, and eccentricity distributions of planets and stellar companions, determine the upper mass of planets, understand the nature of the brown-dwarf desert, and put strong constrains on the theory of planet and binary formation and evolution."
Max ERC Funding
1 737 600 €
Duration
Start date: 2012-01-01, End date: 2016-12-31
Project acronym CHEMPLAN
Project Astrochemistry and the Origin of Planetary Systems
Researcher (PI) Ewine Fleur Van Dishoeck
Host Institution (HI) UNIVERSITEIT LEIDEN
Call Details Advanced Grant (AdG), PE9, ERC-2011-ADG_20110209
Summary When interstellar clouds collapse to form new stars and planets, the surrounding gas and dust become part of the infalling envelopes and rotating disks, thus providing the basic material from which new solar systems are made. Instrumentation to probe the physics and chemistry in low-mass star-forming regions has so far lacked spatial resolution. I propose here an integrated observational-modeling-laboratory program to survey protostars and disks on the relevant scales of 1-50 AU where planet formation takes place. The observations are centered on new data coming from the Atacama Large Millimeter / submillimeter Array (ALMA), and the analysis includes unique new data from key programs on Herschel, Spitzer and VLT that I am (co-)leading. The combination of millimeter and infrared data allows the full range of temperatures from 10-2000 K in star- and planet- forming regions to be probed, for both gas and solids. The molecular line data are used as diagnostics of physical parameters (such as UV field, cosmic ray ionization rate, kinematics, mixing, shock strength, grain growth, gas/dust ratios) as well as to follow the chemistry of water and complex organic molecules from cores to disks, which ultimately may be delivered to terrestrial planets. The implications for the history of volatile material in our own solar systen and exo-planetary atmospheres will be assessed by comparing models and data with cometary taxonomy and, ultimately, feeding them into planet population synthesis models. Altogether, this program will bring the link between interstellar chemistry and solar system and exo-planetary research to a new level.
The project will train four PhD students in a truly interdisciplinary environment in which they are exposed to all aspects of molecular astrophysics and have access to ample ALMA expertise, and it will prepare two postdocs for future faculty positions.
Summary
When interstellar clouds collapse to form new stars and planets, the surrounding gas and dust become part of the infalling envelopes and rotating disks, thus providing the basic material from which new solar systems are made. Instrumentation to probe the physics and chemistry in low-mass star-forming regions has so far lacked spatial resolution. I propose here an integrated observational-modeling-laboratory program to survey protostars and disks on the relevant scales of 1-50 AU where planet formation takes place. The observations are centered on new data coming from the Atacama Large Millimeter / submillimeter Array (ALMA), and the analysis includes unique new data from key programs on Herschel, Spitzer and VLT that I am (co-)leading. The combination of millimeter and infrared data allows the full range of temperatures from 10-2000 K in star- and planet- forming regions to be probed, for both gas and solids. The molecular line data are used as diagnostics of physical parameters (such as UV field, cosmic ray ionization rate, kinematics, mixing, shock strength, grain growth, gas/dust ratios) as well as to follow the chemistry of water and complex organic molecules from cores to disks, which ultimately may be delivered to terrestrial planets. The implications for the history of volatile material in our own solar systen and exo-planetary atmospheres will be assessed by comparing models and data with cometary taxonomy and, ultimately, feeding them into planet population synthesis models. Altogether, this program will bring the link between interstellar chemistry and solar system and exo-planetary research to a new level.
The project will train four PhD students in a truly interdisciplinary environment in which they are exposed to all aspects of molecular astrophysics and have access to ample ALMA expertise, and it will prepare two postdocs for future faculty positions.
Max ERC Funding
2 499 150 €
Duration
Start date: 2012-07-01, End date: 2018-06-30
Project acronym CHROMPHYS
Project Physics of the Solar Chromosphere
Researcher (PI) Mats Per-Olof Carlsson
Host Institution (HI) UNIVERSITETET I OSLO
Call Details Advanced Grant (AdG), PE9, ERC-2011-ADG_20110209
Summary CHROMPHYS aims at a breakthrough in our understanding of the solar chromosphere by combining the development of sophisticated radiation-magnetohydrodynamic simulations with observations from the upcoming NASA SMEX mission Interface Region Imaging Spectrograph (IRIS).
The enigmatic chromosphere is the transition between the solar surface and the eruptive outer solar atmosphere. The chromosphere harbours and constrains the mass and energy loading processes that define the heating of the corona, the acceleration and the composition of the solar wind, and the energetics and triggering of solar outbursts (filament eruptions, flares, coronal mass ejections) that govern near-Earth space weather and affect mankind's technological environment.
CHROMPHYS targets the following fundamental physics questions about the chromospheric role in the mass and energy loading of the corona:
- Which types of non-thermal energy dominate in the chromosphere and beyond?
- How does the chromosphere regulate mass and energy supply to the corona and the solar wind?
- How do magnetic flux and matter rise through the chromosphere?
- How does the chromosphere affect the free magnetic energy loading that leads to solar eruptions?
CHROMPHYS proposes to answer these by producing a new, physics based vista of the chromosphere through a three-fold effort:
- develop the techniques of high-resolution numerical MHD physics to the level needed to realistically predict and analyse small-scale chromospheric structure and dynamics,
- optimise and calibrate diverse observational diagnostics by synthesizing these in detail from the simulations, and
- obtain and analyse data from IRIS using these diagnostics complemented by data from other space missions and the best solar telescopes on the ground.
Summary
CHROMPHYS aims at a breakthrough in our understanding of the solar chromosphere by combining the development of sophisticated radiation-magnetohydrodynamic simulations with observations from the upcoming NASA SMEX mission Interface Region Imaging Spectrograph (IRIS).
The enigmatic chromosphere is the transition between the solar surface and the eruptive outer solar atmosphere. The chromosphere harbours and constrains the mass and energy loading processes that define the heating of the corona, the acceleration and the composition of the solar wind, and the energetics and triggering of solar outbursts (filament eruptions, flares, coronal mass ejections) that govern near-Earth space weather and affect mankind's technological environment.
CHROMPHYS targets the following fundamental physics questions about the chromospheric role in the mass and energy loading of the corona:
- Which types of non-thermal energy dominate in the chromosphere and beyond?
- How does the chromosphere regulate mass and energy supply to the corona and the solar wind?
- How do magnetic flux and matter rise through the chromosphere?
- How does the chromosphere affect the free magnetic energy loading that leads to solar eruptions?
CHROMPHYS proposes to answer these by producing a new, physics based vista of the chromosphere through a three-fold effort:
- develop the techniques of high-resolution numerical MHD physics to the level needed to realistically predict and analyse small-scale chromospheric structure and dynamics,
- optimise and calibrate diverse observational diagnostics by synthesizing these in detail from the simulations, and
- obtain and analyse data from IRIS using these diagnostics complemented by data from other space missions and the best solar telescopes on the ground.
Max ERC Funding
2 487 600 €
Duration
Start date: 2012-01-01, End date: 2016-12-31
Project acronym CLOCKWORKGREEN
Project Ecological performance of arrhythmic plants in nature
Researcher (PI) Ian Thomas Baldwin
Host Institution (HI) MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Call Details Advanced Grant (AdG), LS8, ERC-2011-ADG_20110310
Summary Timing is everything in ecology, and because plants provide the foundation for most land-based food webs, the timing of their activities profoundly orchestrates the majority of ecological interactions. Most photosynthetic and growth processes are under circadian control, but many additional processes--approximately 30-40% of all genes—are under circadian control, and yet the Darwinian fitness impact of being “in synch” with the environment has not been systematically studied for any organism.
We have developed a toolbox for a native tobacco plant, Nicotiana attenuata, that allows us to “ask the plant” which genes, proteins or metabolites are regulated in particular plant-mediated ecological interactions; identify “the genes that matter” for a given interaction; silence or ectopically express these genes, and conduct field releases with the transformed plants at a nature preserve in the Great Basin Desert to rigorously test hypotheses of gene function. By taking advantage of both our understanding of what it takes for this plant to survive in nature, and the procedures established to disentangle the skein of subtle interactions that determine its performance, we will systematically examine the importance of synchronous entrained endogenous rhythms at all life stages: longevity in the seed bank, germination, rosette growth, elongation, flowering and senescence. Specifically, we propose to silence a key components (starting with NaTOC1) of the plant’s endogenous clock to shorten the plant’s circadian rhythm, both constitutively and with strong dexamethasone-inducible promoters, at all life stages. With a combination of real-time phenotype imaging, metabolite and transcriptome analysis, and ecological know-how, the research will reveal how plants adjust their physiologies to the ever-changing panoply of environmental stresses with which they must cope; by creating arrhythmic plants, we will understand why so many processes are under circadian control.
Summary
Timing is everything in ecology, and because plants provide the foundation for most land-based food webs, the timing of their activities profoundly orchestrates the majority of ecological interactions. Most photosynthetic and growth processes are under circadian control, but many additional processes--approximately 30-40% of all genes—are under circadian control, and yet the Darwinian fitness impact of being “in synch” with the environment has not been systematically studied for any organism.
We have developed a toolbox for a native tobacco plant, Nicotiana attenuata, that allows us to “ask the plant” which genes, proteins or metabolites are regulated in particular plant-mediated ecological interactions; identify “the genes that matter” for a given interaction; silence or ectopically express these genes, and conduct field releases with the transformed plants at a nature preserve in the Great Basin Desert to rigorously test hypotheses of gene function. By taking advantage of both our understanding of what it takes for this plant to survive in nature, and the procedures established to disentangle the skein of subtle interactions that determine its performance, we will systematically examine the importance of synchronous entrained endogenous rhythms at all life stages: longevity in the seed bank, germination, rosette growth, elongation, flowering and senescence. Specifically, we propose to silence a key components (starting with NaTOC1) of the plant’s endogenous clock to shorten the plant’s circadian rhythm, both constitutively and with strong dexamethasone-inducible promoters, at all life stages. With a combination of real-time phenotype imaging, metabolite and transcriptome analysis, and ecological know-how, the research will reveal how plants adjust their physiologies to the ever-changing panoply of environmental stresses with which they must cope; by creating arrhythmic plants, we will understand why so many processes are under circadian control.
Max ERC Funding
2 496 002 €
Duration
Start date: 2012-04-01, End date: 2017-03-31
Project acronym DARKLIGHT
Project ILLUMINATING DARK ENERGY WITH THE NEXT GENERATION OF COSMOLOGICAL REDSHIFT SURVEYS
Researcher (PI) Luigi Guzzo
Host Institution (HI) UNIVERSITA DEGLI STUDI DI MILANO
Call Details Advanced Grant (AdG), PE9, ERC-2011-ADG_20110209
Summary Galaxy redshift surveys have been central in establishing the current successful cosmological model. Reconstructing the large-scale distribution of galaxies in space and time, they provide us with a unique probe of the basic constituents of the Universe, their evolution and the background fundamental physics. A new generation of even larger surveys is planned for the starting decade, with the aim of solving the remaining mysteries of the standard model using high-precision measurements of galaxy clustering. These entail the nature of the “dark sector” and in particular the origin of the accelerated cosmic expansion. While data accumulation already started, the needed analysis capabilities to reach the required percent levels in both accuracy and precision are not ready yet.
I propose to establish a focused research group to develop these tools and optimally analyze the new data, while being directly involved in their collection. New techniques as redshift-space distortions and well-known but still debated probes as galaxy clusters will be refined to a new level. They will be combined with more standard methods as baryonic acoustic oscillations and external data as CMB anisotropies. Performances will be validated on mock samples from large numerical simulations and then applied to state-of-the-art data with enhanced control over systematic errors to obtain the best achievable measurements.
These new capabilities will be decisive in enabling ongoing and future surveys to tackle the key open problems in cosmology: What is the nature of dark energy? Is it produced by an evolving scalar field? Or does it rather require a modification of the laws of gravity? How does it relate to dark matter? What is the role of neutrinos? The answer to these questions may well revolutionize our view of physics.
Summary
Galaxy redshift surveys have been central in establishing the current successful cosmological model. Reconstructing the large-scale distribution of galaxies in space and time, they provide us with a unique probe of the basic constituents of the Universe, their evolution and the background fundamental physics. A new generation of even larger surveys is planned for the starting decade, with the aim of solving the remaining mysteries of the standard model using high-precision measurements of galaxy clustering. These entail the nature of the “dark sector” and in particular the origin of the accelerated cosmic expansion. While data accumulation already started, the needed analysis capabilities to reach the required percent levels in both accuracy and precision are not ready yet.
I propose to establish a focused research group to develop these tools and optimally analyze the new data, while being directly involved in their collection. New techniques as redshift-space distortions and well-known but still debated probes as galaxy clusters will be refined to a new level. They will be combined with more standard methods as baryonic acoustic oscillations and external data as CMB anisotropies. Performances will be validated on mock samples from large numerical simulations and then applied to state-of-the-art data with enhanced control over systematic errors to obtain the best achievable measurements.
These new capabilities will be decisive in enabling ongoing and future surveys to tackle the key open problems in cosmology: What is the nature of dark energy? Is it produced by an evolving scalar field? Or does it rather require a modification of the laws of gravity? How does it relate to dark matter? What is the role of neutrinos? The answer to these questions may well revolutionize our view of physics.
Max ERC Funding
1 723 600 €
Duration
Start date: 2012-05-01, End date: 2017-10-31