Project acronym ZooMWest
Project Zooarchaeology and Mobility in the Western Mediterranean: husbandry production from the Late Bronze Age to Late Antiquity
Researcher (PI) Silvia VALENZUELA LAMAS
Host Institution (HI) AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Call Details Starting Grant (StG), SH6, ERC-2016-STG
Summary Human survival and success is substantially determined by the ability to move across the landscape and adapt. Consequently, ‘mobility’ is a crucial topic in historical and archaeological research. To overcome the seasonal scarcity of food and the related over-grazing of pastures, it is essential for animal husbandry to move across territories. However, the decision to allow or deny rights of way to mobile people and livestock depends on political judgements. How might these shape animal husbandry production, and society?
The period between the Late Bronze Age and Late Antiquity in the Western Mediterranean witnessed the development of complex societies with a high territorial component, the Roman conquest, and the decline of the Western Roman Empire. Animal husbandry reflects human decisions regarding the management of resources, and the study of livestock rearing in specific geographical locations is possible through the isotopic analysis of ancient animal teeth. Consequently, we can analyse whether the nucleation of power occurring during the Bronze and Iron Ages, the centralization in Roman times and the later re-fragmentation in Late Antiquity transformed animal husbandry production. Crucially, we can then understand how political systems and decisions shaped human mobility through investigating animal production.
ZooMWest brings together isotopic chemistry, ancient DNA, zooarchaeology and geospatial analysis through four related work packages. Other than elucidating long term debates in archaeology –did transhumance exist in prehistoric Europe?–, this multidisciplinary and innovative project will create an open-access database of strontium and oxygen stable isotopes of the Iberian Peninsula and Italy. This database will enable us to refine geographic provenance to any discipline assessing the origin of matter, including geology, forensic studies, and the alimentary industry, as strontium and oxygen are present in many molecules, including organic tissues.
Summary
Human survival and success is substantially determined by the ability to move across the landscape and adapt. Consequently, ‘mobility’ is a crucial topic in historical and archaeological research. To overcome the seasonal scarcity of food and the related over-grazing of pastures, it is essential for animal husbandry to move across territories. However, the decision to allow or deny rights of way to mobile people and livestock depends on political judgements. How might these shape animal husbandry production, and society?
The period between the Late Bronze Age and Late Antiquity in the Western Mediterranean witnessed the development of complex societies with a high territorial component, the Roman conquest, and the decline of the Western Roman Empire. Animal husbandry reflects human decisions regarding the management of resources, and the study of livestock rearing in specific geographical locations is possible through the isotopic analysis of ancient animal teeth. Consequently, we can analyse whether the nucleation of power occurring during the Bronze and Iron Ages, the centralization in Roman times and the later re-fragmentation in Late Antiquity transformed animal husbandry production. Crucially, we can then understand how political systems and decisions shaped human mobility through investigating animal production.
ZooMWest brings together isotopic chemistry, ancient DNA, zooarchaeology and geospatial analysis through four related work packages. Other than elucidating long term debates in archaeology –did transhumance exist in prehistoric Europe?–, this multidisciplinary and innovative project will create an open-access database of strontium and oxygen stable isotopes of the Iberian Peninsula and Italy. This database will enable us to refine geographic provenance to any discipline assessing the origin of matter, including geology, forensic studies, and the alimentary industry, as strontium and oxygen are present in many molecules, including organic tissues.
Max ERC Funding
1 199 319 €
Duration
Start date: 2017-04-01, End date: 2021-03-31
Project acronym ZPR
Project The Pancreas Regulome: From causality to prediction of non-coding mutations in human pancreatic diseases
Researcher (PI) José Carlos Ribeiro Bessa
Host Institution (HI) INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR-IBMC
Call Details Starting Grant (StG), LS2, ERC-2015-STG
Summary Several human pancreatic diseases have been characterized, being the diabetes the most common. Like others, this genetic disease is related to disrupted non-coding cis-regulatory elements (CREs) that culminate in altered gene expression. Although Genome Wide Association Studies support this hypothesis, it’s still unclear how mutations on CREs contribute to disease. The translation from the “non-coding code” to phenotype is an exciting and unexplored field that we will approach in this project with the help of the zebrafish as a suitable animal model. We aim to uncover the implications of the disruption of pancreas CREs and how they contribute to diabetes in vivo. For this we will study transcriptional regulation of genes in zebrafish. The similarities between zebrafish and mammal pancreas and the evolutionary conservation of pancreas transcription factors (TF) make it an excellent model to approach and study this disease. In this project we will characterize the zebrafish insulin producing beta-cell regulome, by determining the active CREs in this cell type and their bound TFs. Then we will compare this information with a similar dataset recently available for human beta-cells, to define functional orthologs in these species. Selected CREs will be tested by in vivo gene reporter assays in zebrafish, focusing on those functionally equivalent to human CREs where risk alleles have been associated with diabetes or those regulating genes involved in diabetes. Later these CREs will be mutated in the zebrafish genome to validate their contribution to diabetes. Finally we will translate this to predict new human disease-associated CREs by focusing on the regulatory landscape of diabetes-associated genes, without the need of having countless patients to uncover them. With this project we will create a model system that will allow the identification of new diabetes-associated CREs, which might have a great impact in clinical management of this epidemic disease.
Summary
Several human pancreatic diseases have been characterized, being the diabetes the most common. Like others, this genetic disease is related to disrupted non-coding cis-regulatory elements (CREs) that culminate in altered gene expression. Although Genome Wide Association Studies support this hypothesis, it’s still unclear how mutations on CREs contribute to disease. The translation from the “non-coding code” to phenotype is an exciting and unexplored field that we will approach in this project with the help of the zebrafish as a suitable animal model. We aim to uncover the implications of the disruption of pancreas CREs and how they contribute to diabetes in vivo. For this we will study transcriptional regulation of genes in zebrafish. The similarities between zebrafish and mammal pancreas and the evolutionary conservation of pancreas transcription factors (TF) make it an excellent model to approach and study this disease. In this project we will characterize the zebrafish insulin producing beta-cell regulome, by determining the active CREs in this cell type and their bound TFs. Then we will compare this information with a similar dataset recently available for human beta-cells, to define functional orthologs in these species. Selected CREs will be tested by in vivo gene reporter assays in zebrafish, focusing on those functionally equivalent to human CREs where risk alleles have been associated with diabetes or those regulating genes involved in diabetes. Later these CREs will be mutated in the zebrafish genome to validate their contribution to diabetes. Finally we will translate this to predict new human disease-associated CREs by focusing on the regulatory landscape of diabetes-associated genes, without the need of having countless patients to uncover them. With this project we will create a model system that will allow the identification of new diabetes-associated CREs, which might have a great impact in clinical management of this epidemic disease.
Max ERC Funding
1 497 520 €
Duration
Start date: 2016-06-01, End date: 2021-05-31
