Project acronym AFRISCREENWORLDS
Project African Screen Worlds: Decolonising Film and Screen Studies
Researcher (PI) Lindiwe Dovey
Host Institution (HI) SCHOOL OF ORIENTAL AND AFRICAN STUDIES ROYAL CHARTER
Call Details Consolidator Grant (CoG), SH5, ERC-2018-COG
Summary A half century since it came into existence, the discipline of Film and Screen Studies remains mostly Eurocentric in its historical, theoretical and critical frameworks. Although “world cinema” and “transnational cinema” scholars have attempted to broaden its canon and frameworks, several major problems persist. Films and scholarship by Africans in particular, and by people of colour in general, are frequently marginalised if not altogether excluded. This prevents exciting exchanges that could help to re-envision Film and Screen Studies for the twenty-first century, in an era in which greater access to the technological means of making films, and circulating them on a range of screens, means that dynamic “screen worlds” are developing at a rapid rate. AFRISCREENWORLDS will study these “screen worlds” (in both their textual forms and industrial structures), with a focus on Africa, as a way of centring the most marginalised regional cinema. We will also elaborate comparative studies of global “screen worlds” – and, in particular, “screen worlds” in the Global South – exploring their similarities, differences, and parallel developments. We will respond to the exclusions of Film and Screen Studies not only in scholarly ways – through conferences and publications – but also in creative and activist ways – through drawing on cutting-edge creative research methodologies (such as audiovisual criticism and filmmaking) and through helping to decolonise Film and Screen Studies (through the production of ‘toolkits’ on how to make curricula, syllabi, and teaching more globally representative and inclusive). On a theoretical level, we will make an intervention through considering how the concept of “screen worlds” is better equipped than “world cinema” or “transnational cinema” to explore the complexities of audiovisual narratives, and their production and circulation in our contemporary moment, in diverse contexts throughout the globe.
Summary
A half century since it came into existence, the discipline of Film and Screen Studies remains mostly Eurocentric in its historical, theoretical and critical frameworks. Although “world cinema” and “transnational cinema” scholars have attempted to broaden its canon and frameworks, several major problems persist. Films and scholarship by Africans in particular, and by people of colour in general, are frequently marginalised if not altogether excluded. This prevents exciting exchanges that could help to re-envision Film and Screen Studies for the twenty-first century, in an era in which greater access to the technological means of making films, and circulating them on a range of screens, means that dynamic “screen worlds” are developing at a rapid rate. AFRISCREENWORLDS will study these “screen worlds” (in both their textual forms and industrial structures), with a focus on Africa, as a way of centring the most marginalised regional cinema. We will also elaborate comparative studies of global “screen worlds” – and, in particular, “screen worlds” in the Global South – exploring their similarities, differences, and parallel developments. We will respond to the exclusions of Film and Screen Studies not only in scholarly ways – through conferences and publications – but also in creative and activist ways – through drawing on cutting-edge creative research methodologies (such as audiovisual criticism and filmmaking) and through helping to decolonise Film and Screen Studies (through the production of ‘toolkits’ on how to make curricula, syllabi, and teaching more globally representative and inclusive). On a theoretical level, we will make an intervention through considering how the concept of “screen worlds” is better equipped than “world cinema” or “transnational cinema” to explore the complexities of audiovisual narratives, and their production and circulation in our contemporary moment, in diverse contexts throughout the globe.
Max ERC Funding
1 985 578 €
Duration
Start date: 2019-06-01, End date: 2024-05-31
Project acronym CHRONO
Project Chronotype, health and family: The role of biology, socio- and natural environment and their interaction
Researcher (PI) Melinda MILLS
Host Institution (HI) THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Call Details Advanced Grant (AdG), SH3, ERC-2018-ADG
Summary The widespread use of electronic devices, artificial light and rise of the 24-hour economy means that more individuals experience disruption of their chronotype, which is the natural circadian rhythm that regulates sleep and activity levels. The natural and medical sciences focus on the natural environment (e.g., light exposure), genetics, biology and health consequences, whereas the social sciences have largely explored the socio-environment (e.g., working regulations) and psychological and familial consequences of nonstandard work schedules. For the first time CHRONO bridges these disparate disciplines to ask: What is the role of biology, the natural and socio-environment and their interaction on predicting and understanding resilience to chronotype disruption and how does this in turn impact an individual’s health (sleep, cancer, obesity, digestive problems) and family (partnership, children) outcomes? I propose to: (1) develop a multifactor interdisciplinary theoretical model; (2) disrupt data collection by crowdsourcing a sociogenomic dataset with novel measures; (3) discover and validate with informed machine learning innovative measures of chronotype (molecular genetic, accelerometer, microbiome, patient-record, self-reported) and the natural and socio-environment; (4) ask fundamentally new substantive questions to determine how chronotype disruption influences health and family outcomes and, via Biology x Environment interaction (BxE), whether this is moderated by the natural or socio-environment; and, (5) develop new statistical models and methods to cope with contentious issues, answer longitudinal questions and engage in novel quasi-experiments (e.g., policy and life course changes) to transcend description to identify endogenous factors and causal mechanisms. Interdisciplinary in the truest sense, CHRONO will overturn long-held substantive findings of the causes and consequences of chronotype disruption.
Summary
The widespread use of electronic devices, artificial light and rise of the 24-hour economy means that more individuals experience disruption of their chronotype, which is the natural circadian rhythm that regulates sleep and activity levels. The natural and medical sciences focus on the natural environment (e.g., light exposure), genetics, biology and health consequences, whereas the social sciences have largely explored the socio-environment (e.g., working regulations) and psychological and familial consequences of nonstandard work schedules. For the first time CHRONO bridges these disparate disciplines to ask: What is the role of biology, the natural and socio-environment and their interaction on predicting and understanding resilience to chronotype disruption and how does this in turn impact an individual’s health (sleep, cancer, obesity, digestive problems) and family (partnership, children) outcomes? I propose to: (1) develop a multifactor interdisciplinary theoretical model; (2) disrupt data collection by crowdsourcing a sociogenomic dataset with novel measures; (3) discover and validate with informed machine learning innovative measures of chronotype (molecular genetic, accelerometer, microbiome, patient-record, self-reported) and the natural and socio-environment; (4) ask fundamentally new substantive questions to determine how chronotype disruption influences health and family outcomes and, via Biology x Environment interaction (BxE), whether this is moderated by the natural or socio-environment; and, (5) develop new statistical models and methods to cope with contentious issues, answer longitudinal questions and engage in novel quasi-experiments (e.g., policy and life course changes) to transcend description to identify endogenous factors and causal mechanisms. Interdisciplinary in the truest sense, CHRONO will overturn long-held substantive findings of the causes and consequences of chronotype disruption.
Max ERC Funding
2 499 811 €
Duration
Start date: 2019-11-01, End date: 2024-10-31
Project acronym CLaSS
Project Climate, Landscape, Settlement and Society: Exploring Human-Environment Interaction in the Ancient Near East
Researcher (PI) Daniel LAWRENCE
Host Institution (HI) UNIVERSITY OF DURHAM
Call Details Starting Grant (StG), SH6, ERC-2018-STG
Summary Over the last 8000 years, the Fertile Crescent of the Near East has seen the emergence of cities, states and empires. Climate fluctuations are generally considered to be a significant factor in these changes because in pre-industrial societies they directly relate to food production and security. In the short term, ‘collapse’ events brought about by extreme weather changes such as droughts have been blamed for declines in population, social complexity and political systems. More broadly, the relationships between environment, settlement and surplus drive most models for the development of urbanism and hierarchical political systems.
Studies seeking to correlate social and climatic changes in the past tend either to focus on highly localised analyses of specific sites and surveys or to take a more synthetic overview at much larger, even continental, scales. The CLaSS project will take a ground breaking hybrid approach using archaeological data science (or ‘big data’) to construct detailed, empirical datasets at unprecedented scales. Archaeological settlement data and archaeobotanical data (plant and tree remains) will be collated for the entire Fertile Crescent and combined with climate simulations derived from General Circulation Models using cutting edge techniques. The resulting datasets will represent the largest of their kind ever compiled, covering the period between 8000BP and 2000BP and an area of 600,000km2.
Collecting data at this scale will enable us to compare population densities and distribution, subsistence practices and landscape management strategies to investigate the question: What factors have allowed for the differential persistence of societies in the face of changing climatic and environmental conditions? This ambitious project will provide insights into the sustainability and resilience of societies through both abrupt and longer term climate changes, leveraging the deep time perspective only available to archaeology.
Summary
Over the last 8000 years, the Fertile Crescent of the Near East has seen the emergence of cities, states and empires. Climate fluctuations are generally considered to be a significant factor in these changes because in pre-industrial societies they directly relate to food production and security. In the short term, ‘collapse’ events brought about by extreme weather changes such as droughts have been blamed for declines in population, social complexity and political systems. More broadly, the relationships between environment, settlement and surplus drive most models for the development of urbanism and hierarchical political systems.
Studies seeking to correlate social and climatic changes in the past tend either to focus on highly localised analyses of specific sites and surveys or to take a more synthetic overview at much larger, even continental, scales. The CLaSS project will take a ground breaking hybrid approach using archaeological data science (or ‘big data’) to construct detailed, empirical datasets at unprecedented scales. Archaeological settlement data and archaeobotanical data (plant and tree remains) will be collated for the entire Fertile Crescent and combined with climate simulations derived from General Circulation Models using cutting edge techniques. The resulting datasets will represent the largest of their kind ever compiled, covering the period between 8000BP and 2000BP and an area of 600,000km2.
Collecting data at this scale will enable us to compare population densities and distribution, subsistence practices and landscape management strategies to investigate the question: What factors have allowed for the differential persistence of societies in the face of changing climatic and environmental conditions? This ambitious project will provide insights into the sustainability and resilience of societies through both abrupt and longer term climate changes, leveraging the deep time perspective only available to archaeology.
Max ERC Funding
1 498 650 €
Duration
Start date: 2019-01-01, End date: 2023-12-31
Project acronym CLD
Project China, Law, and Development
Researcher (PI) Matthew ERIE
Host Institution (HI) THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Call Details Starting Grant (StG), SH2, ERC-2018-STG
Summary The world is in the midst of a sea change in approaches to development. The rise of nationalist politics in the U.S., U.K. and Europe have questioned commitments to global governance at the same time that China has emerged as a champion of globalization, a turn of geo-political events that would have been unfathomable ten years ago. Through its own multi-lateral institutions, China is setting a new agenda for development from Europe to Oceania. China’s approach differs from Anglo/Euro/American approaches to “law and development” (LD). Whereas LD orthodoxy has sought to improve legal institutions in poor states, Chinese do not foster rule of law abroad. Instead, Chinese view law as one set of rules, among others, to facilitate economic transactions and not to foster democratization. This distinction has sparked a global debate about the so-called “China model” as an alternative to LD. Yet there is little empirical data with which to assess the means and ends of China’s expanded footprint, a question with long-term implications for much of the developing world. This project addresses that problem by proposing that even if Chinese cross-border development does not operate through transparent rules, it nonetheless has its own notion of order. The project adopts a multi-sited, mixed method, and interdisciplinary approach—at the intersection of comparative law, developmental studies, and legal anthropology—to understand the nature of China’s order. The project has two objectives:
1. To establish the conceptual bases for the study of China’s approach to law and development by developing the first systematic study of the impacts of Chinese investment on the legal systems of developing economies.
2. To experiment with a comparative research design to theorize how China’s approach suggests a type of order that extends through a conjuncture of regional and local processes and manifests itself differently in diverse contexts.
Summary
The world is in the midst of a sea change in approaches to development. The rise of nationalist politics in the U.S., U.K. and Europe have questioned commitments to global governance at the same time that China has emerged as a champion of globalization, a turn of geo-political events that would have been unfathomable ten years ago. Through its own multi-lateral institutions, China is setting a new agenda for development from Europe to Oceania. China’s approach differs from Anglo/Euro/American approaches to “law and development” (LD). Whereas LD orthodoxy has sought to improve legal institutions in poor states, Chinese do not foster rule of law abroad. Instead, Chinese view law as one set of rules, among others, to facilitate economic transactions and not to foster democratization. This distinction has sparked a global debate about the so-called “China model” as an alternative to LD. Yet there is little empirical data with which to assess the means and ends of China’s expanded footprint, a question with long-term implications for much of the developing world. This project addresses that problem by proposing that even if Chinese cross-border development does not operate through transparent rules, it nonetheless has its own notion of order. The project adopts a multi-sited, mixed method, and interdisciplinary approach—at the intersection of comparative law, developmental studies, and legal anthropology—to understand the nature of China’s order. The project has two objectives:
1. To establish the conceptual bases for the study of China’s approach to law and development by developing the first systematic study of the impacts of Chinese investment on the legal systems of developing economies.
2. To experiment with a comparative research design to theorize how China’s approach suggests a type of order that extends through a conjuncture of regional and local processes and manifests itself differently in diverse contexts.
Max ERC Funding
1 499 381 €
Duration
Start date: 2019-01-01, End date: 2023-12-31
Project acronym COMMIOS
Project Communities and Connectivities: Iron Age Britons and their Continental Neighbours
Researcher (PI) Ian ARMIT
Host Institution (HI) UNIVERSITY OF LEICESTER
Call Details Advanced Grant (AdG), SH6, ERC-2018-ADG
Summary Recent breakthroughs in ancient DNA and isotope analysis are transforming our understanding of diversity, mobility and social dynamics in the human past. COMMIOS integrates these cutting-edge methods on a scale not previously attempted, within a ground-breaking interdisciplinary framework, to provide a radically new vision of Iron Age communities in Britain (800 BC – AD 100) within their wider European context.
At the broad scale, we will conduct the first concerted programme of genome-wide ancient DNA analysis on Iron Age populations anywhere in the world (c. 1000 individuals in the UK, 250 in Europe), mapping genetic clusters to shed light on ancient populations themselves and on their relationships to modern genetic patterning. Together with isotope analysis, and underpinned by both osteoarchaeological and cultural archaeological approaches, this will also enable us to directly address critical issues of population movement and inter-regional connectivity in Iron Age Europe. We will utilise the power of these new scientific methods to examine the structure and social dynamics of Iron Age societies in Britain, including household and kin-group composition, the identification of familial relationships, gender-specific mobility, and the development of social inequalities. Previously the preserve of cultural anthropologists studying recent societies, we will draw these questions into the archaeological domain, opening up new areas of enquiry for prehistoric societies.
The scope and scale of the project represents a new departure for European archaeology, made possible by the coming-of-age of new analytical methods. Many of these have been pioneered by the project team, which comprises world-leaders in the fields of ancient DNA, isotope analysis, osteoarchaeology, chronological modelling and cultural archaeology. Although focussed on Iron Age Britain, the project will establish a new benchmark for future analyses of other regions and periods in Europe and beyond.
Summary
Recent breakthroughs in ancient DNA and isotope analysis are transforming our understanding of diversity, mobility and social dynamics in the human past. COMMIOS integrates these cutting-edge methods on a scale not previously attempted, within a ground-breaking interdisciplinary framework, to provide a radically new vision of Iron Age communities in Britain (800 BC – AD 100) within their wider European context.
At the broad scale, we will conduct the first concerted programme of genome-wide ancient DNA analysis on Iron Age populations anywhere in the world (c. 1000 individuals in the UK, 250 in Europe), mapping genetic clusters to shed light on ancient populations themselves and on their relationships to modern genetic patterning. Together with isotope analysis, and underpinned by both osteoarchaeological and cultural archaeological approaches, this will also enable us to directly address critical issues of population movement and inter-regional connectivity in Iron Age Europe. We will utilise the power of these new scientific methods to examine the structure and social dynamics of Iron Age societies in Britain, including household and kin-group composition, the identification of familial relationships, gender-specific mobility, and the development of social inequalities. Previously the preserve of cultural anthropologists studying recent societies, we will draw these questions into the archaeological domain, opening up new areas of enquiry for prehistoric societies.
The scope and scale of the project represents a new departure for European archaeology, made possible by the coming-of-age of new analytical methods. Many of these have been pioneered by the project team, which comprises world-leaders in the fields of ancient DNA, isotope analysis, osteoarchaeology, chronological modelling and cultural archaeology. Although focussed on Iron Age Britain, the project will establish a new benchmark for future analyses of other regions and periods in Europe and beyond.
Max ERC Funding
2 499 872 €
Duration
Start date: 2019-10-01, End date: 2024-09-30
Project acronym DEVORHBIOSHIP
Project The Developmental Origins of Health: Biology, Shocks, Investments, and Policies
Researcher (PI) Gabriella CONTI
Host Institution (HI) UNIVERSITY COLLEGE LONDON
Call Details Consolidator Grant (CoG), SH1, ERC-2018-COG
Summary What are the origins of inequalities in health? A recent literature in economics has established causal impacts of early life shocks, investments and policies on lifelong health. However, several unknowns remain. The mechanisms through which shocks, investments, and policies interact are just beginning to be understood. Our knowledge of sensitive periods is imprecise. Little is also known about the impact of shocks and policies across different ages. Commonly used health capital measures, such as birth weight, lack sensitivity and specificity. The interplay between genes and environments in the formation of health inequalities is poorly understood.
To fill these gaps, I will build on insights from my earlier work, and use a combination of high-quality data, more sensitive measures, robust identification strategies and richer models to untangle the complex interactions between biology, shocks, investments and policies.
First, I will investigate causal impacts and mechanisms of two public health policies on child health and development: medical treatments for pregnancy complications and prenatal home visiting programmes. Second, I will examine the effects of two environmental shocks (pollution and influenza) on the formation of early health and human capital, and their interplay with maternal investments in nutrition. Third, I will study interactions between shocks, investments and policies from birth to adulthood, to understand the dynamic interplay between SES and health. Throughout, I will explore their interactions with genetic susceptibility or potential.
I will analyse administrative records, registries linked to survey data, cohort data with biomarkers; and a randomized controlled trial. I will use state-of-the-art econometric techniques for observational and experimental data. My findings will have direct policy implications and will help understand whether and to which extent early life interventions are a cost-effective mean to promote health.
Summary
What are the origins of inequalities in health? A recent literature in economics has established causal impacts of early life shocks, investments and policies on lifelong health. However, several unknowns remain. The mechanisms through which shocks, investments, and policies interact are just beginning to be understood. Our knowledge of sensitive periods is imprecise. Little is also known about the impact of shocks and policies across different ages. Commonly used health capital measures, such as birth weight, lack sensitivity and specificity. The interplay between genes and environments in the formation of health inequalities is poorly understood.
To fill these gaps, I will build on insights from my earlier work, and use a combination of high-quality data, more sensitive measures, robust identification strategies and richer models to untangle the complex interactions between biology, shocks, investments and policies.
First, I will investigate causal impacts and mechanisms of two public health policies on child health and development: medical treatments for pregnancy complications and prenatal home visiting programmes. Second, I will examine the effects of two environmental shocks (pollution and influenza) on the formation of early health and human capital, and their interplay with maternal investments in nutrition. Third, I will study interactions between shocks, investments and policies from birth to adulthood, to understand the dynamic interplay between SES and health. Throughout, I will explore their interactions with genetic susceptibility or potential.
I will analyse administrative records, registries linked to survey data, cohort data with biomarkers; and a randomized controlled trial. I will use state-of-the-art econometric techniques for observational and experimental data. My findings will have direct policy implications and will help understand whether and to which extent early life interventions are a cost-effective mean to promote health.
Max ERC Funding
1 738 763 €
Duration
Start date: 2019-04-01, End date: 2024-03-31
Project acronym DiCED
Project Digital Campaigning and Electoral Democracy
Researcher (PI) Rachel GIBSON
Host Institution (HI) THE UNIVERSITY OF MANCHESTER
Call Details Advanced Grant (AdG), SH2, ERC-2018-ADG
Summary Overview: This project will set a new agenda and direction for the study of political campaigns. It will examine whether and how new digital technologies are transforming election campaigns and citizen behaviour in new and established democracies. More specifically, it will assess claims that democracies are now entering a new data-driven era of political campaigning that is profoundly reconfiguring how campaigns’ are run, who runs them and their implications for the quality of voter decision-making, the vibrancy of political parties and ultimately, the future of representative democracy. It will do so in three main stages: (1) First, it will define what data-driven campaigning is and critically assess whether it forms new and distinct era of electioneering in conceptual and historical terms? In particular, it will argue that the two key traits of this new mode of campaigning are the increased individualization or micro-targeting of party messages and the automated use of misinformation to mobilize and persuade voters. (2) Based on this definition it will map the ‘supply’ of the new mode of campaigning across new and older democracies by designing an innovative new index to compare use of data-driven techniques by parties. Where is it most commonly seen and why are some parties and countries more likely to promote its growth? (3) Finally, it will assess the impact of these new methods on key political actors and assess the consequences for the longer term future of liberal democracy. Does use of these techniques help counter recent declines in voter turnout by identifying under-mobilized groups? Or, do they ensure parties focus on the already engaged, bypassing those that are harder to reach? Can data-driven campaigning improve citizen choices by giving them the information on the issues they primarily care about or does it help to increase disinformation and even manipulation of voter choices?
Summary
Overview: This project will set a new agenda and direction for the study of political campaigns. It will examine whether and how new digital technologies are transforming election campaigns and citizen behaviour in new and established democracies. More specifically, it will assess claims that democracies are now entering a new data-driven era of political campaigning that is profoundly reconfiguring how campaigns’ are run, who runs them and their implications for the quality of voter decision-making, the vibrancy of political parties and ultimately, the future of representative democracy. It will do so in three main stages: (1) First, it will define what data-driven campaigning is and critically assess whether it forms new and distinct era of electioneering in conceptual and historical terms? In particular, it will argue that the two key traits of this new mode of campaigning are the increased individualization or micro-targeting of party messages and the automated use of misinformation to mobilize and persuade voters. (2) Based on this definition it will map the ‘supply’ of the new mode of campaigning across new and older democracies by designing an innovative new index to compare use of data-driven techniques by parties. Where is it most commonly seen and why are some parties and countries more likely to promote its growth? (3) Finally, it will assess the impact of these new methods on key political actors and assess the consequences for the longer term future of liberal democracy. Does use of these techniques help counter recent declines in voter turnout by identifying under-mobilized groups? Or, do they ensure parties focus on the already engaged, bypassing those that are harder to reach? Can data-driven campaigning improve citizen choices by giving them the information on the issues they primarily care about or does it help to increase disinformation and even manipulation of voter choices?
Max ERC Funding
2 499 394 €
Duration
Start date: 2019-11-01, End date: 2024-10-31
Project acronym DNA-DOCK
Project Precision Docking of Very Large DNA Cargos in Mammalian Genomes
Researcher (PI) Imre Berger
Host Institution (HI) UNIVERSITY OF BRISTOL
Call Details Advanced Grant (AdG), LS9, ERC-2018-ADG
Summary Gene editing has developed at breath-taking speed. In particular CRISPR/Cas9 provides a tool-set thousands of researchers worldwide now utilize with unprecedented ease to edit genes, catalysing a broad range of biomedical and industrial applications. Gene synthesis technologies producing thousands of base pairs of synthetic DNA have become affordable. Current gene editing technology is highly effective for local, small genomic DNA edits and insertions. To unlock the full potential of this revolution, however, our capacities to disrupt or rewrite small local elements of code must be complemented by equal capacities to efficiently insert very large synthetic DNA cargos with a wide range of functions into genomic sites. Large designer cargos would carry multicomponent DNA circuitry including programmable and fine-tuneable functionalities, representing the vital interface between gene editing which is the state-of-the-art at present, and genome engineering, which is the future. This challenge remained largely unaddressed to date.
We aspire to resolve this bottleneck by creating ground-breaking, generally applicable, easy-to-use technology to enable docking of large DNA cargos with base pair precision and unparalleled efficiency into mammalian genomes. To achieve our ambitious goals, we will apply a whole array of sophisticated tools. We will unlock a small non-human virus to rational design, creating safe, flexible and easy-to-produce, large capacity DNA delivery nanodevices with unmatched transduction capability. We will exploit a range of techniques including Darwinian in vitro selection/evolution to accomplish unprecedented precision DNA integration efficiency into genomic sites. We will use parallelized DNA assembly methods to generate multifunctional circuits, to accelerate T cell engineering, resolving unmet needs. Once we accomplish our tasks, our technology has the potential to be exceptionally rewarding to the scientific, industrial and medical communities.
Summary
Gene editing has developed at breath-taking speed. In particular CRISPR/Cas9 provides a tool-set thousands of researchers worldwide now utilize with unprecedented ease to edit genes, catalysing a broad range of biomedical and industrial applications. Gene synthesis technologies producing thousands of base pairs of synthetic DNA have become affordable. Current gene editing technology is highly effective for local, small genomic DNA edits and insertions. To unlock the full potential of this revolution, however, our capacities to disrupt or rewrite small local elements of code must be complemented by equal capacities to efficiently insert very large synthetic DNA cargos with a wide range of functions into genomic sites. Large designer cargos would carry multicomponent DNA circuitry including programmable and fine-tuneable functionalities, representing the vital interface between gene editing which is the state-of-the-art at present, and genome engineering, which is the future. This challenge remained largely unaddressed to date.
We aspire to resolve this bottleneck by creating ground-breaking, generally applicable, easy-to-use technology to enable docking of large DNA cargos with base pair precision and unparalleled efficiency into mammalian genomes. To achieve our ambitious goals, we will apply a whole array of sophisticated tools. We will unlock a small non-human virus to rational design, creating safe, flexible and easy-to-produce, large capacity DNA delivery nanodevices with unmatched transduction capability. We will exploit a range of techniques including Darwinian in vitro selection/evolution to accomplish unprecedented precision DNA integration efficiency into genomic sites. We will use parallelized DNA assembly methods to generate multifunctional circuits, to accelerate T cell engineering, resolving unmet needs. Once we accomplish our tasks, our technology has the potential to be exceptionally rewarding to the scientific, industrial and medical communities.
Max ERC Funding
2 498 578 €
Duration
Start date: 2019-09-01, End date: 2024-08-31
Project acronym DYNNET
Project Opinion Dynamics
Researcher (PI) Friederike MENGEL
Host Institution (HI) UNIVERSITY OF ESSEX
Call Details Starting Grant (StG), SH1, ERC-2018-STG
Summary In this project I propose to study opinion dynamics in social networks and groups. In particular, I will ask how opinion dynamics contribute to shape social identity and how, conversely, social identity affects communication. I also ask whether and when social identity is a barrier to communication, when “opinion bubbles” are created and when and how “fake news” can spread. The types of social identity I consider include social class, ethnicity and gender. The project consists of four subprojects.
The first subproject [A] focuses on communication between social classes and inequality. The subproject asks how opinion dynamics contribute to diverging experiences, core behaviours and values that go much beyond income inequality. I will first document this divergence by conducting experiments in a representative sample of the UK population via the UK Household panel and then conduct lab experiments to study opinion dynamics and the conditions under which “opinion bubbles” arise in more detail.
Subproject [B] focuses on gender bias in committees. A large body of empirical evidence has documented gender biases in decisions, such as hiring, promotion, or performance evaluations. Many of these decisions involve communication and deliberation among committee members. Nevertheless the role of opinion dynamics in committees in creating or amplifying gender bias has not been explored. Subproject [B] aims to fill this gap.
Subproject [C] will focus on how perceived uncertainty contributes to the spread of discriminatory attitudes with a particular focus on ethnic discrimination. Subproject [C] will be conducted both using a representative sample of the UK population via the Innovation Panel of Understanding Society, the UK Household panel as well as lab experiments.
The last subproject [D] will use lab experiments to study under which conditions opinion dynamics can become vulnerable to “fake news”.
Summary
In this project I propose to study opinion dynamics in social networks and groups. In particular, I will ask how opinion dynamics contribute to shape social identity and how, conversely, social identity affects communication. I also ask whether and when social identity is a barrier to communication, when “opinion bubbles” are created and when and how “fake news” can spread. The types of social identity I consider include social class, ethnicity and gender. The project consists of four subprojects.
The first subproject [A] focuses on communication between social classes and inequality. The subproject asks how opinion dynamics contribute to diverging experiences, core behaviours and values that go much beyond income inequality. I will first document this divergence by conducting experiments in a representative sample of the UK population via the UK Household panel and then conduct lab experiments to study opinion dynamics and the conditions under which “opinion bubbles” arise in more detail.
Subproject [B] focuses on gender bias in committees. A large body of empirical evidence has documented gender biases in decisions, such as hiring, promotion, or performance evaluations. Many of these decisions involve communication and deliberation among committee members. Nevertheless the role of opinion dynamics in committees in creating or amplifying gender bias has not been explored. Subproject [B] aims to fill this gap.
Subproject [C] will focus on how perceived uncertainty contributes to the spread of discriminatory attitudes with a particular focus on ethnic discrimination. Subproject [C] will be conducted both using a representative sample of the UK population via the Innovation Panel of Understanding Society, the UK Household panel as well as lab experiments.
The last subproject [D] will use lab experiments to study under which conditions opinion dynamics can become vulnerable to “fake news”.
Max ERC Funding
830 623 €
Duration
Start date: 2018-12-01, End date: 2022-11-30
Project acronym EMPORIGIN
Project What are the origins of empathy? A comparative developmental investigation
Researcher (PI) Susanna Elizabeth Valerie CLAY
Host Institution (HI) UNIVERSITY OF DURHAM
Call Details Starting Grant (StG), SH4, ERC-2018-STG
Summary Empathy – sharing and understanding others’ emotions and thoughts – is a defining feature of what it means to be human. However, we lack knowledge about the origins of empathy and to what extent its sub-components reflect species and cultural universals. Studying infants and great apes enables us to identify the developmental and evolutionary origins of empathy and the extent of its human uniqueness. Until now, it has largely been assumed that infants and great apes lack the capacity for empathy. However, this claim may reflect a lack of adequate methodologies and research attention, leaving infant and great ape empathy underestimated. Now, combining novel techniques to investigate empathy comparatively (thermal-imaging, pupillometry and eye-tracking) with longitudinal observations and innovative experiments, EMPORIGIN will overcome this issue to provide the first comparative investigation of empathy development in humans and bonobos, our closest living relatives. Rich datasets on bonobo (wild and semi-captive) infant development and caregiver interactions will be compared to those from human infants in two small-scale, traditional societies – Vanuatu and Samoa. Both societies show distributed-caregiving but vary in societal structure and emotional expressivity. Using a cross-species and cross-cultural approach, EMPORIGIN will deliver step-change insights into empathy development that go far beyond the State-of-the-Art. We will test the hypothesis that humans and bonobos share a core capacity for empathy, but humans diverge in a greater motivation to ameliorate others’ emotional states and a capacity for reciprocal emotional exchange. These capacities could lead to a cascade of human-unique forms of sharing and co-operation. Combining approaches across biology, psychology, ethology and anthropology, EMPORIGIN will advance our understanding of the origins of empathy, one of our most remarkable capacities, and challenge current perspectives about its human uniqueness.
Summary
Empathy – sharing and understanding others’ emotions and thoughts – is a defining feature of what it means to be human. However, we lack knowledge about the origins of empathy and to what extent its sub-components reflect species and cultural universals. Studying infants and great apes enables us to identify the developmental and evolutionary origins of empathy and the extent of its human uniqueness. Until now, it has largely been assumed that infants and great apes lack the capacity for empathy. However, this claim may reflect a lack of adequate methodologies and research attention, leaving infant and great ape empathy underestimated. Now, combining novel techniques to investigate empathy comparatively (thermal-imaging, pupillometry and eye-tracking) with longitudinal observations and innovative experiments, EMPORIGIN will overcome this issue to provide the first comparative investigation of empathy development in humans and bonobos, our closest living relatives. Rich datasets on bonobo (wild and semi-captive) infant development and caregiver interactions will be compared to those from human infants in two small-scale, traditional societies – Vanuatu and Samoa. Both societies show distributed-caregiving but vary in societal structure and emotional expressivity. Using a cross-species and cross-cultural approach, EMPORIGIN will deliver step-change insights into empathy development that go far beyond the State-of-the-Art. We will test the hypothesis that humans and bonobos share a core capacity for empathy, but humans diverge in a greater motivation to ameliorate others’ emotional states and a capacity for reciprocal emotional exchange. These capacities could lead to a cascade of human-unique forms of sharing and co-operation. Combining approaches across biology, psychology, ethology and anthropology, EMPORIGIN will advance our understanding of the origins of empathy, one of our most remarkable capacities, and challenge current perspectives about its human uniqueness.
Max ERC Funding
1 499 829 €
Duration
Start date: 2019-03-01, End date: 2024-02-29
