Project acronym AARTFAAC
Project Amsterdam-ASTRON Radio Transient Facility And Analysis Centre: Probing the Extremes of Astrophysics
Researcher (PI) Ralph Antoine Marie Joseph Wijers
Host Institution (HI) UNIVERSITEIT VAN AMSTERDAM
Call Details Advanced Grant (AdG), PE9, ERC-2009-AdG
Summary Some of the most extreme tests of physical law come from its manifestations in the behaviour of black holes and neutron stars, and as such these objects should be used as fundamental physics labs. Due to advances in both theoretical work and observational techniques, I have a major opportunity now to significantly push this agenda forward and get better answers to questions like: How are black holes born? How can energy be extracted from black holes? What is the origin of magnetic fields and cosmic rays in jets and shocks? Is their primary energy stream hadronic or magnetic? I propose to do this by exploiting the advent of wide-field radio astronomy: extreme objects are very rare and usually transient, so not only must one survey large areas of sky, but also must one do this often. I propose to form and shape a group that will use the LOFAR wide-field radio telescope to hunt for these extreme transients and systematically collect enough well-documented examples of the behaviour of each type of transient. Furthermore, I propose to expand LOFAR with a true 24/7 all-sky monitor to catch and study even the rarest of events. Next, I will use my experience in gamma-ray burst followup to conduct a vigorous multi-wavelength programme of study of these objects, to constrain their physics from as many angles as possible. This will eventually include results from multi-messenger astrophysics, in which we use neutrinos, gravity waves, and other non-electromagnetic messengers as extra diagnostics of the physics of these sources. Finally, I will build on my experience in modelling accretion phenomena and relativistic explosions to develop a theoretical framework for these phenomena and constrain the resulting models with the rich data sets we obtain.
Summary
Some of the most extreme tests of physical law come from its manifestations in the behaviour of black holes and neutron stars, and as such these objects should be used as fundamental physics labs. Due to advances in both theoretical work and observational techniques, I have a major opportunity now to significantly push this agenda forward and get better answers to questions like: How are black holes born? How can energy be extracted from black holes? What is the origin of magnetic fields and cosmic rays in jets and shocks? Is their primary energy stream hadronic or magnetic? I propose to do this by exploiting the advent of wide-field radio astronomy: extreme objects are very rare and usually transient, so not only must one survey large areas of sky, but also must one do this often. I propose to form and shape a group that will use the LOFAR wide-field radio telescope to hunt for these extreme transients and systematically collect enough well-documented examples of the behaviour of each type of transient. Furthermore, I propose to expand LOFAR with a true 24/7 all-sky monitor to catch and study even the rarest of events. Next, I will use my experience in gamma-ray burst followup to conduct a vigorous multi-wavelength programme of study of these objects, to constrain their physics from as many angles as possible. This will eventually include results from multi-messenger astrophysics, in which we use neutrinos, gravity waves, and other non-electromagnetic messengers as extra diagnostics of the physics of these sources. Finally, I will build on my experience in modelling accretion phenomena and relativistic explosions to develop a theoretical framework for these phenomena and constrain the resulting models with the rich data sets we obtain.
Max ERC Funding
3 499 128 €
Duration
Start date: 2010-10-01, End date: 2016-09-30
Project acronym CORALWARM
Project Corals and global warming: The Mediterranean versus the Red Sea
Researcher (PI) Zvy Dubinsky
Host Institution (HI) BAR ILAN UNIVERSITY
Call Details Advanced Grant (AdG), LS8, ERC-2009-AdG
Summary CoralWarm will generate for the first time projections of temperate and subtropical coral survival by integrating sublethal temperature increase effects on metabolic and skeletal processes in Mediterranean and Red Sea key species. CoralWarm unique approach is from the nano- to the macro-scale, correlating molecular events to environmental processes. This will show new pathways to future investigations on cellular mechanisms linking environmental factors to final phenotype, potentially improving prediction powers and paleoclimatological interpretation. Biological and chemical expertise will merge, producing new interdisciplinary approaches for ecophysiology and biomineralization. Field transplantations will be combined with controlled experiments under IPCC scenarios. Corals will be grown in aquaria, exposing the Mediterranean species native to cooler waters to higher temperatures, and the Red Sea ones to gradually increasing above ambient warming seawater. Virtually all state-of-the-art methods will be used, by uniquely combining the investigators expertise. Expected results include responses of algal symbionts photosynthesis, host, symbiont and holobiont respiration, biomineralization rates and patterns, including colony architecture, and reproduction to temperature and pH gradients and combinations. Integration of molecular aspects of potential replacement of symbiont clades, changes in skeletal crystallography, with biochemical and physiological aspects of temperature response, will lead to a novel mechanistic model predicting changes in coral ecology and survival prospect. High-temperature tolerant clades and species will be revealed, allowing future bioremediation actions and establishment of coral refuges, saving corals and coral reefs for future generations.
Summary
CoralWarm will generate for the first time projections of temperate and subtropical coral survival by integrating sublethal temperature increase effects on metabolic and skeletal processes in Mediterranean and Red Sea key species. CoralWarm unique approach is from the nano- to the macro-scale, correlating molecular events to environmental processes. This will show new pathways to future investigations on cellular mechanisms linking environmental factors to final phenotype, potentially improving prediction powers and paleoclimatological interpretation. Biological and chemical expertise will merge, producing new interdisciplinary approaches for ecophysiology and biomineralization. Field transplantations will be combined with controlled experiments under IPCC scenarios. Corals will be grown in aquaria, exposing the Mediterranean species native to cooler waters to higher temperatures, and the Red Sea ones to gradually increasing above ambient warming seawater. Virtually all state-of-the-art methods will be used, by uniquely combining the investigators expertise. Expected results include responses of algal symbionts photosynthesis, host, symbiont and holobiont respiration, biomineralization rates and patterns, including colony architecture, and reproduction to temperature and pH gradients and combinations. Integration of molecular aspects of potential replacement of symbiont clades, changes in skeletal crystallography, with biochemical and physiological aspects of temperature response, will lead to a novel mechanistic model predicting changes in coral ecology and survival prospect. High-temperature tolerant clades and species will be revealed, allowing future bioremediation actions and establishment of coral refuges, saving corals and coral reefs for future generations.
Max ERC Funding
3 332 032 €
Duration
Start date: 2010-06-01, End date: 2016-05-31
Project acronym DCENSY
Project Doping, Charge Transfer and Energy Flow in Hybrid Nanoparticle Systems
Researcher (PI) Uri Banin
Host Institution (HI) THE HEBREW UNIVERSITY OF JERUSALEM
Call Details Advanced Grant (AdG), PE4, ERC-2009-AdG
Summary We target a frontier in nanocrystal science of combining disparate materials into a single hybrid nanosystem. This offers an intriguing route to engineer nanomaterials with multiple functionalities in ways that are not accessible in bulk materials or in molecules. Such control of novel material combinations on a single nanoparticle or in a super-structure of assembled nanoparticles, presents alongside with the synthesis challenges, fundamental questions concerning the physical attributes of nanoscale systems. My goals are to create new highly controlled hybrid nanoparticle systems, focusing on combinations of semiconductors and metals, and to decipher the fundamental principles governing doping in nanoparticles and charge and energy transfer processes among components of the hybrid systems. The research addresses several key challenges: First, in synthesis, combining disparate material components into one hybrid nanoparticle system. Second, in self assembly, organizing a combination of semiconductor (SC) and metal nanoparticle building blocks into hybrid systems with controlled architecture. Third in fundamental physico-chemical questions pertaining to the unique attributes of the hybrid systems, constituting a key component of the research. A first aspect concerns doping of SC nanoparticles with metal atoms. A second aspect concerns light-induced charge transfer between the SC part and metal parts of the hybrid constructs. A third related aspect concerns energy transfer processes between the SC and metal components and the interplay between near-field enhancement and fluorescence quenching effects. Due to the new properties, significant impact on nanocrystal applications in solar energy harvesting, biological tagging, sensing, optics and electropotics is expected.
Summary
We target a frontier in nanocrystal science of combining disparate materials into a single hybrid nanosystem. This offers an intriguing route to engineer nanomaterials with multiple functionalities in ways that are not accessible in bulk materials or in molecules. Such control of novel material combinations on a single nanoparticle or in a super-structure of assembled nanoparticles, presents alongside with the synthesis challenges, fundamental questions concerning the physical attributes of nanoscale systems. My goals are to create new highly controlled hybrid nanoparticle systems, focusing on combinations of semiconductors and metals, and to decipher the fundamental principles governing doping in nanoparticles and charge and energy transfer processes among components of the hybrid systems. The research addresses several key challenges: First, in synthesis, combining disparate material components into one hybrid nanoparticle system. Second, in self assembly, organizing a combination of semiconductor (SC) and metal nanoparticle building blocks into hybrid systems with controlled architecture. Third in fundamental physico-chemical questions pertaining to the unique attributes of the hybrid systems, constituting a key component of the research. A first aspect concerns doping of SC nanoparticles with metal atoms. A second aspect concerns light-induced charge transfer between the SC part and metal parts of the hybrid constructs. A third related aspect concerns energy transfer processes between the SC and metal components and the interplay between near-field enhancement and fluorescence quenching effects. Due to the new properties, significant impact on nanocrystal applications in solar energy harvesting, biological tagging, sensing, optics and electropotics is expected.
Max ERC Funding
2 499 000 €
Duration
Start date: 2010-06-01, End date: 2015-05-31
Project acronym DIRECTDELIVERY
Project Controlled fusion of liposomes and cells: a new pathway for direct drug delivery
Researcher (PI) Alexander Kros
Host Institution (HI) UNIVERSITEIT LEIDEN
Call Details Starting Grant (StG), PE5, ERC-2009-StG
Summary Inspired by the natural membrane fusion machinery, the aim of this research line is to design a synthetic analogue in order to: 1) Understand the process of the peptide-controlled fusion of two membranes at the atomic, molecular and mesoscopic level. 2) Developing a new generic method for the controlled delivery of any (bio)molecule directly into the cytoplasm of a cell thereby omitting endocytotic pathways. This new paradigm opens many new applications in the fields of functional proteomics, genomics and siRNA-technology. Studying, imitating and dissecting processes from Nature and applying the underlying principles has been highly successful approach for many years and opened up new lines of research and applications which were previously unimagineable. Examples are the aptamer and antibody technology. I will use this learning-from-Nature approach to design synthetic analogues of the membrane fusion machinery to create new functions and/or applications which are currently non-existent. Membrane fusion is a key process in all living cells as it facilitates the transport of molecules between and within cells. A primary mechanism by which molecules are conveyed to the appropriate location is to encapsulate them in liposomes that deliver the cargo by fusing with the lipid membrane of the target cell or compartment. I will use synthetic analogues of the membrane fusion machinery to induce the controlled fusion between 1) specific liposomes and 2) liposome-cell. This approach opens up a new paradigm for the direct introduction of (bio)molecule into the cytoplasm of living cells omitting the endocytotic pathways for which the applications are only limited by one s imagination.
Summary
Inspired by the natural membrane fusion machinery, the aim of this research line is to design a synthetic analogue in order to: 1) Understand the process of the peptide-controlled fusion of two membranes at the atomic, molecular and mesoscopic level. 2) Developing a new generic method for the controlled delivery of any (bio)molecule directly into the cytoplasm of a cell thereby omitting endocytotic pathways. This new paradigm opens many new applications in the fields of functional proteomics, genomics and siRNA-technology. Studying, imitating and dissecting processes from Nature and applying the underlying principles has been highly successful approach for many years and opened up new lines of research and applications which were previously unimagineable. Examples are the aptamer and antibody technology. I will use this learning-from-Nature approach to design synthetic analogues of the membrane fusion machinery to create new functions and/or applications which are currently non-existent. Membrane fusion is a key process in all living cells as it facilitates the transport of molecules between and within cells. A primary mechanism by which molecules are conveyed to the appropriate location is to encapsulate them in liposomes that deliver the cargo by fusing with the lipid membrane of the target cell or compartment. I will use synthetic analogues of the membrane fusion machinery to induce the controlled fusion between 1) specific liposomes and 2) liposome-cell. This approach opens up a new paradigm for the direct introduction of (bio)molecule into the cytoplasm of living cells omitting the endocytotic pathways for which the applications are only limited by one s imagination.
Max ERC Funding
1 392 262 €
Duration
Start date: 2009-10-01, End date: 2014-09-30
Project acronym ERGODICNONCOMPACT
Project Ergodic theory on non compact spaces
Researcher (PI) Omri Moshe Sarig
Host Institution (HI) WEIZMANN INSTITUTE OF SCIENCE
Call Details Starting Grant (StG), PE1, ERC-2009-StG
Summary The proposal is to look for, and investigate, new ergodic theoretic types of behavior for dynamical systems which act on non compact spaces. These could include transience and non-trivial ways of escape to infinity, critical phenomena similar to phase transitions, and new types of measure rigidity. There are potential applications to smooth ergodic theory (non-uniform hyperbolicity), algebraic ergodic theory (actions on homogeneous spaces), and probability theory (weakly dependent stochastic processes).
Summary
The proposal is to look for, and investigate, new ergodic theoretic types of behavior for dynamical systems which act on non compact spaces. These could include transience and non-trivial ways of escape to infinity, critical phenomena similar to phase transitions, and new types of measure rigidity. There are potential applications to smooth ergodic theory (non-uniform hyperbolicity), algebraic ergodic theory (actions on homogeneous spaces), and probability theory (weakly dependent stochastic processes).
Max ERC Funding
539 479 €
Duration
Start date: 2009-10-01, End date: 2014-09-30
Project acronym GALACTICA
Project Dynamical imprints of the evolutionary history of the Milky Way
Researcher (PI) Amina Helmi
Host Institution (HI) RIJKSUNIVERSITEIT GRONINGEN
Call Details Starting Grant (StG), PE9, ERC-2009-StG
Summary Galactic Astronomy is entering a new era, driven by state-of-the-art instrumentation and large surveys, and by the dramatic leaps in our understanding of galaxy formation provided by the cosmological LCDM framework. These surveys have shown that the Galaxy is up for discoveries every single month, and have revealed the first footprints of past mergers. This Era will reach its summit when the Gaia mission, scheduled for launch in 2011, provides the much-awaited survey of Galactic phase-space for a billion stars. This motivates us to propose a program that will provide a comprehensive view of the dynamical imprints leftover from the Galaxy s evolutionary history. This program will address the following key questions: How much memory does a galaxy like the Milky Way retain of its past? What is the relative importance of internally driven (secular processes) and externally acquired (mergers) phase-space substructure? What was the merging history of the Galaxy? Is the Galaxy consistent with LCDM? This ambitious program will advance the field of Galactic archaeology beyond the state-of-the-art thanks to two developments: the Aquarius Project simulations and the RAVE spectroscopic survey. The Aquarius are the largest ever cosmological simulations of a Milky Way dark matter halo. When complemented with a recently built phenomenological galaxy formation model, these superb simulations will serve for comparisons to the latest observational datasets, and in particular to the RAVE survey that is providing a fantastic dynamical map of the Solar vicinity. This will enable us to be in prime position to exploit the first Gaia data release in 2013, and before the end of this Research Program, to harvest its key scientific goal, namely to unravel the assembly history of the Milky Way.
Summary
Galactic Astronomy is entering a new era, driven by state-of-the-art instrumentation and large surveys, and by the dramatic leaps in our understanding of galaxy formation provided by the cosmological LCDM framework. These surveys have shown that the Galaxy is up for discoveries every single month, and have revealed the first footprints of past mergers. This Era will reach its summit when the Gaia mission, scheduled for launch in 2011, provides the much-awaited survey of Galactic phase-space for a billion stars. This motivates us to propose a program that will provide a comprehensive view of the dynamical imprints leftover from the Galaxy s evolutionary history. This program will address the following key questions: How much memory does a galaxy like the Milky Way retain of its past? What is the relative importance of internally driven (secular processes) and externally acquired (mergers) phase-space substructure? What was the merging history of the Galaxy? Is the Galaxy consistent with LCDM? This ambitious program will advance the field of Galactic archaeology beyond the state-of-the-art thanks to two developments: the Aquarius Project simulations and the RAVE spectroscopic survey. The Aquarius are the largest ever cosmological simulations of a Milky Way dark matter halo. When complemented with a recently built phenomenological galaxy formation model, these superb simulations will serve for comparisons to the latest observational datasets, and in particular to the RAVE survey that is providing a fantastic dynamical map of the Solar vicinity. This will enable us to be in prime position to exploit the first Gaia data release in 2013, and before the end of this Research Program, to harvest its key scientific goal, namely to unravel the assembly history of the Milky Way.
Max ERC Funding
1 613 680 €
Duration
Start date: 2010-01-01, End date: 2015-12-31
Project acronym GLC
Project Langlands correspondence and its variants
Researcher (PI) David Kazhdan
Host Institution (HI) THE HEBREW UNIVERSITY OF JERUSALEM
Call Details Advanced Grant (AdG), PE1, ERC-2009-AdG
Summary Sometimes in the sciences there are different yet complementary descriptions for the same object. This extends to the particle-wave duality of quantum mechanics; one mathematical analog of this duality is the Fourier transform. Questions that are difficult when formulated in one language of science may become simple when interpreted in another. The Langlands conjecture posits the existence of a correspondence between problems in arithmetic and in Representation Theory. The Langlands conjecture has only been proven for a limited number of cases, but even this has solved problems such as the famous Fermat conjecture. The aim of this project is to continue study of the "classical" aspects of the Langlands conjecture and to extend the conjecture to the quantum geometric Langlands correspondence, higher-dimensional fields, Kac-Moody groups (with D.Gaitsgory: quantum Langlands correspondence; D.Gaitsgory and E. Hrushevsi: groups over higher-dimensional fields; A. Braverman: Kac-Moody groups; R. Bezrukavnikov, S.Debacker, Y.Varshavsky: classical aspects of the correspondence; A. Berenstein: geometric crystals and crystal bases). The quantum case is much more symmetric than the classical case and can lead in the limit q->0 to new insights into the classical case. The quantum case is also related to the multiple Dirichlet series. New results in the quantum case would lead to progress in understanding important Number Theoretic questions. Extending the Langlands correspondence to groups over higher-dimensional fields could substantially enlarge its applicability. Studying Kac-Moody groups would provide tools for the new important class of L-functions. This progress could lead to a proof of the existence of the analytic continuation of classical L-functions. The geometric Langlands correspondence is closely related to T-symmetry in 4-dimensional gauge theory and the understanding of this relation is important for both Mathematics and Physics.
Summary
Sometimes in the sciences there are different yet complementary descriptions for the same object. This extends to the particle-wave duality of quantum mechanics; one mathematical analog of this duality is the Fourier transform. Questions that are difficult when formulated in one language of science may become simple when interpreted in another. The Langlands conjecture posits the existence of a correspondence between problems in arithmetic and in Representation Theory. The Langlands conjecture has only been proven for a limited number of cases, but even this has solved problems such as the famous Fermat conjecture. The aim of this project is to continue study of the "classical" aspects of the Langlands conjecture and to extend the conjecture to the quantum geometric Langlands correspondence, higher-dimensional fields, Kac-Moody groups (with D.Gaitsgory: quantum Langlands correspondence; D.Gaitsgory and E. Hrushevsi: groups over higher-dimensional fields; A. Braverman: Kac-Moody groups; R. Bezrukavnikov, S.Debacker, Y.Varshavsky: classical aspects of the correspondence; A. Berenstein: geometric crystals and crystal bases). The quantum case is much more symmetric than the classical case and can lead in the limit q->0 to new insights into the classical case. The quantum case is also related to the multiple Dirichlet series. New results in the quantum case would lead to progress in understanding important Number Theoretic questions. Extending the Langlands correspondence to groups over higher-dimensional fields could substantially enlarge its applicability. Studying Kac-Moody groups would provide tools for the new important class of L-functions. This progress could lead to a proof of the existence of the analytic continuation of classical L-functions. The geometric Langlands correspondence is closely related to T-symmetry in 4-dimensional gauge theory and the understanding of this relation is important for both Mathematics and Physics.
Max ERC Funding
1 277 060 €
Duration
Start date: 2010-01-01, End date: 2014-12-31
Project acronym HI-ONE
Project Hybrid Inorganic-Organic NanoElectronics
Researcher (PI) Wilfred Gerard Van Der Wiel
Host Institution (HI) UNIVERSITEIT TWENTE
Call Details Starting Grant (StG), PE3, ERC-2009-StG
Summary This project aims at combining inorganic and organic materials in hybrid nanoelectronic structures for addressing a set of key problems in solid-state physics: (1) the magnetic ordering of 2D spin systems and their interaction with conduction electrons, (2) the coherent transport properties of organic molecules, and (3) reliable electronic characterization of single nanostructures. For all objectives we will integrate top-down and bottom-up (self-assembly) techniques, benefitting from strong collaborations with leading chemistry groups. For Objective 1, we will apply self-assembled monolayers of organic paramagnetic molecules on various substrates. This geometry offers great tunability for the nature, density and ordering of spins, and for their interaction with underlying electrons. We will study (many-body) phenomena that lie at the very heart of solid-state physics: the Kondo effect, RKKY interaction, spin glasses and the 2D Ising/Heisenberg model, addressing open questions concerning the extension of the Kondo cloud, RKKY-Kondo competition, and the relevance for high-Tc superconductivity. For Objective 2, molecular monolayers are inserted in an electron interferometer, allowing a systematic study of molecular charge coherence. We will study how coherence depends on the molecule s characteristics, such as length and chemical composition. For Objective 3 we will attach single nanostructures (quantum dots) by an innovative self-assembly method to highly-conductive, selectively metallized DNA molecules, bridging the gap between nano and micro. A crucial advantage compared to conventional (top-down) nanocontacting schemes is the high control and reproducibility afforded by sequence-specificity of DNA hybridization, enabling a wide range of fascinating experiments.
Summary
This project aims at combining inorganic and organic materials in hybrid nanoelectronic structures for addressing a set of key problems in solid-state physics: (1) the magnetic ordering of 2D spin systems and their interaction with conduction electrons, (2) the coherent transport properties of organic molecules, and (3) reliable electronic characterization of single nanostructures. For all objectives we will integrate top-down and bottom-up (self-assembly) techniques, benefitting from strong collaborations with leading chemistry groups. For Objective 1, we will apply self-assembled monolayers of organic paramagnetic molecules on various substrates. This geometry offers great tunability for the nature, density and ordering of spins, and for their interaction with underlying electrons. We will study (many-body) phenomena that lie at the very heart of solid-state physics: the Kondo effect, RKKY interaction, spin glasses and the 2D Ising/Heisenberg model, addressing open questions concerning the extension of the Kondo cloud, RKKY-Kondo competition, and the relevance for high-Tc superconductivity. For Objective 2, molecular monolayers are inserted in an electron interferometer, allowing a systematic study of molecular charge coherence. We will study how coherence depends on the molecule s characteristics, such as length and chemical composition. For Objective 3 we will attach single nanostructures (quantum dots) by an innovative self-assembly method to highly-conductive, selectively metallized DNA molecules, bridging the gap between nano and micro. A crucial advantage compared to conventional (top-down) nanocontacting schemes is the high control and reproducibility afforded by sequence-specificity of DNA hybridization, enabling a wide range of fascinating experiments.
Max ERC Funding
1 750 000 €
Duration
Start date: 2009-12-01, End date: 2014-11-30
Project acronym HYDRATIONLUBE
Project Hydration lubrication: exploring a new paradigm
Researcher (PI) Jacob Klein
Host Institution (HI) WEIZMANN INSTITUTE OF SCIENCE
Call Details Advanced Grant (AdG), PE4, ERC-2009-AdG
Summary In recent years, as first established in some 6 papers in Science and Nature from the PI s group, a new paradigm has emerged. This reveals the remarkable and unsuspected - role of hydration layers in modulating frictional forces between sliding surfaces or molecular layers in aqueous media, termed hydration lubrication, in which the lubricating mode is completely different from the classic one of oils or surfactants. In this project we address the substantial challenges that have now arisen: what are the underlying mechanisms controlling this effect? what are the potential breakthroughs that it may lead to? We will answer these questions through several interrelated objectives designed to address both fundamental aspects, as well as limits of applicability. We will use surface force balance (SFB) experiments, for which we will develop new methodologies, to characterize normal and frictional forces between atomically smooth surfaces where the nature of the surfaces (hydrophilic, hydrophobic, metallic, polymeric), as well as their electric potential, may be independently varied. We will examine mono- and multivalent ions to establish the role of relaxation rates and hydration energies in controlling the hydration lubrication, will probe hydration interactions at both hydrophobic/hydrophilic surfaces and will monitor slip of hydrated ions past surfaces. We will also characterize the hydration lubrication properties of a wide range of novel surface systems, including surfactants, liposomes, polymer brushes and, importantly, liposomes, using also synchrotron X-ray reflectometry for structural information. Attainment of these objectives should lead to conceptual breakthroughs both in our understanding of this new paradigm, and for its practical implications.
Summary
In recent years, as first established in some 6 papers in Science and Nature from the PI s group, a new paradigm has emerged. This reveals the remarkable and unsuspected - role of hydration layers in modulating frictional forces between sliding surfaces or molecular layers in aqueous media, termed hydration lubrication, in which the lubricating mode is completely different from the classic one of oils or surfactants. In this project we address the substantial challenges that have now arisen: what are the underlying mechanisms controlling this effect? what are the potential breakthroughs that it may lead to? We will answer these questions through several interrelated objectives designed to address both fundamental aspects, as well as limits of applicability. We will use surface force balance (SFB) experiments, for which we will develop new methodologies, to characterize normal and frictional forces between atomically smooth surfaces where the nature of the surfaces (hydrophilic, hydrophobic, metallic, polymeric), as well as their electric potential, may be independently varied. We will examine mono- and multivalent ions to establish the role of relaxation rates and hydration energies in controlling the hydration lubrication, will probe hydration interactions at both hydrophobic/hydrophilic surfaces and will monitor slip of hydrated ions past surfaces. We will also characterize the hydration lubrication properties of a wide range of novel surface systems, including surfactants, liposomes, polymer brushes and, importantly, liposomes, using also synchrotron X-ray reflectometry for structural information. Attainment of these objectives should lead to conceptual breakthroughs both in our understanding of this new paradigm, and for its practical implications.
Max ERC Funding
2 304 180 €
Duration
Start date: 2010-05-01, End date: 2015-04-30
Project acronym INTERCOM
Project The Influence of Interfaces, Confinement and Compartmentalization on Chemical Reactions
Researcher (PI) Wilhelm Huck
Host Institution (HI) STICHTING KATHOLIEKE UNIVERSITEIT
Call Details Advanced Grant (AdG), PE4, ERC-2009-AdG
Summary Water is essential for life on our planet and is the solvent of choice for Nature to carry out her syntheses. In contrast, our methods of making complex organic molecules have taken us far away from the watery milieu of biosynthesis. Indeed, it is fair to say that most organic reactions commonly used both in academic laboratories and in industry fail in the presence of water or oxygen. At the same time of course, chemical reactors are very different from the cellular environment where Nature s synthesis is carried out. This research proposal aims to incorporate some of the key characteristic of cellular reactors, i.e. confinement, compartmentalization and interfaces, into model droplet-based reactors. The envisioned reactors will comprise of monodisperse aqueous droplets in oil carrier phases with volumes ranging from pL to nL, produced in microfluidics devices or in tubing, in very large numbers. These droplets will have precisely determined interfacial areas, which can be used for the study of so-called on water reactions, a new area of synthetic chemistry rapidly gaining in interest. Furthermore, the interfaces can be functionalized with catalytically active surfactants and by confining the droplets into ever decreasing volumes, the effect of nanoconfinement on enzymatic and other reactions can be studied. Finally, individual droplets provide a completely compartmentalized environment, suitable for the study of single enzymes in a crowded environment, but also for systematic studies into communication between compartmentalized, mutually incompatible, reaction systems. This proposal presents a radically new approach to increasing our understanding of chemical reactions in confined spaces and at interfaces and provides a technological platform for the creation of chemically linked networks with emerging complexity.
Summary
Water is essential for life on our planet and is the solvent of choice for Nature to carry out her syntheses. In contrast, our methods of making complex organic molecules have taken us far away from the watery milieu of biosynthesis. Indeed, it is fair to say that most organic reactions commonly used both in academic laboratories and in industry fail in the presence of water or oxygen. At the same time of course, chemical reactors are very different from the cellular environment where Nature s synthesis is carried out. This research proposal aims to incorporate some of the key characteristic of cellular reactors, i.e. confinement, compartmentalization and interfaces, into model droplet-based reactors. The envisioned reactors will comprise of monodisperse aqueous droplets in oil carrier phases with volumes ranging from pL to nL, produced in microfluidics devices or in tubing, in very large numbers. These droplets will have precisely determined interfacial areas, which can be used for the study of so-called on water reactions, a new area of synthetic chemistry rapidly gaining in interest. Furthermore, the interfaces can be functionalized with catalytically active surfactants and by confining the droplets into ever decreasing volumes, the effect of nanoconfinement on enzymatic and other reactions can be studied. Finally, individual droplets provide a completely compartmentalized environment, suitable for the study of single enzymes in a crowded environment, but also for systematic studies into communication between compartmentalized, mutually incompatible, reaction systems. This proposal presents a radically new approach to increasing our understanding of chemical reactions in confined spaces and at interfaces and provides a technological platform for the creation of chemically linked networks with emerging complexity.
Max ERC Funding
2 147 726 €
Duration
Start date: 2010-05-01, End date: 2015-04-30
