Project acronym ACO
Project The Proceedings of the Ecumenical Councils from Oral Utterance to Manuscript Edition as Evidence for Late Antique Persuasion and Self-Representation Techniques
Researcher (PI) Peter Alfred Riedlberger
Host Institution (HI) OTTO-FRIEDRICH-UNIVERSITAET BAMBERG
Call Details Starting Grant (StG), SH5, ERC-2015-STG
Summary The Acts of the Ecumenical Councils of Late Antiquity include (purportedly) verbatim minutes of the proceedings, a formal framework and copies of relevant documents which were either (allegedly) read out during the proceedings or which were later attached to the Acts proper. Despite this unusual wealth of documentary evidence, the daunting nature of the Acts demanding multidisciplinary competency, their complex structure with a matryoshka-like nesting of proceedings from different dates, and the stereotype that their contents bear only on Christological niceties have deterred generations of historians from studying them. Only in recent years have their fortunes begun to improve, but this recent research has not always been based on sound principles: the recorded proceedings of the sessions are still often accepted as verbatim minutes. Yet even a superficial reading quickly reveals widespread editorial interference. We must accept that in many cases the Acts will teach us less about the actual debates than about the editors who shaped their presentation. This does not depreciate the Acts’ evidence: on the contrary, they are first-rate material for the rhetoric of persuasion and self-representation. It is possible, in fact, to take the investigation to a deeper level and examine in what manner the oral proceedings were put into writing: several passages in the Acts comment upon the process of note-taking and the work of the shorthand writers. Thus, the main objective of the proposed research project could be described as an attempt to trace the destinies of the Acts’ texts, from the oral utterance to the manuscript texts we have today. This will include the fullest study on ancient transcript techniques to date; a structural analysis of the Acts’ texts with the aim of highlighting edited passages; and a careful comparison of the various editions of the Acts, which survive in Greek, Latin, Syriac and Coptic, in order to detect traces of editorial interference.
Summary
The Acts of the Ecumenical Councils of Late Antiquity include (purportedly) verbatim minutes of the proceedings, a formal framework and copies of relevant documents which were either (allegedly) read out during the proceedings or which were later attached to the Acts proper. Despite this unusual wealth of documentary evidence, the daunting nature of the Acts demanding multidisciplinary competency, their complex structure with a matryoshka-like nesting of proceedings from different dates, and the stereotype that their contents bear only on Christological niceties have deterred generations of historians from studying them. Only in recent years have their fortunes begun to improve, but this recent research has not always been based on sound principles: the recorded proceedings of the sessions are still often accepted as verbatim minutes. Yet even a superficial reading quickly reveals widespread editorial interference. We must accept that in many cases the Acts will teach us less about the actual debates than about the editors who shaped their presentation. This does not depreciate the Acts’ evidence: on the contrary, they are first-rate material for the rhetoric of persuasion and self-representation. It is possible, in fact, to take the investigation to a deeper level and examine in what manner the oral proceedings were put into writing: several passages in the Acts comment upon the process of note-taking and the work of the shorthand writers. Thus, the main objective of the proposed research project could be described as an attempt to trace the destinies of the Acts’ texts, from the oral utterance to the manuscript texts we have today. This will include the fullest study on ancient transcript techniques to date; a structural analysis of the Acts’ texts with the aim of highlighting edited passages; and a careful comparison of the various editions of the Acts, which survive in Greek, Latin, Syriac and Coptic, in order to detect traces of editorial interference.
Max ERC Funding
1 497 250 €
Duration
Start date: 2016-05-01, End date: 2021-04-30
Project acronym ApeAttachment
Project Are social skills determined by early live experiences?
Researcher (PI) Catherine Delia Crockford
Host Institution (HI) MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Call Details Starting Grant (StG), SH4, ERC-2015-STG
Summary Social bonding success in life impacts on health, survival and fitness. It is proposed that early and later social experience as well as heritable factors determine social bonding abilities in adulthood, although the relative influence of each is unclear. In humans, the resulting uncertainty likely impedes psychological and psychiatric assessment and therapy. One problem hampering progress for human studies is that social bonding success is hard to objectively quantify, particularly in adults. I propose to directly address this problem by determining the key influences on social bonding abilities in chimpanzees, our closest living relative, where social bonding success can be objectively quantified, and is defined as number of affiliative relationships maintained over time with high rates of affiliation.
Objectives. This project will quantify the relative impact of early and later social experience as well as heritable factors on social hormone levels, social cognition and social bonding success in 270 wild and captive chimpanzees, using both cohort and longitudinal data. This will reveal the degree of plasticity in social cognition and bonding behaviour throughout life. Finally, it will evaluate the potential for using endogenous hormone levels as non-invasive biomarkers of social bonding success, as well as identifying social contexts that act as strong natural social hormone releasers.
Outcomes. This project will expose what makes some better at social bonding than others. Specifically, it will show the extent to which later social experience can compensate for early social experience or heritable factors in terms of adult social bonding success, the latter being a key factor in determining health and happiness in life. This project also offers the potential for using hormonal biomarkers in clincial settings, as objective assessment of changes in relationships over time, and in therapy by engaging in social behaviours that act as strong social hormone releasers.
Summary
Social bonding success in life impacts on health, survival and fitness. It is proposed that early and later social experience as well as heritable factors determine social bonding abilities in adulthood, although the relative influence of each is unclear. In humans, the resulting uncertainty likely impedes psychological and psychiatric assessment and therapy. One problem hampering progress for human studies is that social bonding success is hard to objectively quantify, particularly in adults. I propose to directly address this problem by determining the key influences on social bonding abilities in chimpanzees, our closest living relative, where social bonding success can be objectively quantified, and is defined as number of affiliative relationships maintained over time with high rates of affiliation.
Objectives. This project will quantify the relative impact of early and later social experience as well as heritable factors on social hormone levels, social cognition and social bonding success in 270 wild and captive chimpanzees, using both cohort and longitudinal data. This will reveal the degree of plasticity in social cognition and bonding behaviour throughout life. Finally, it will evaluate the potential for using endogenous hormone levels as non-invasive biomarkers of social bonding success, as well as identifying social contexts that act as strong natural social hormone releasers.
Outcomes. This project will expose what makes some better at social bonding than others. Specifically, it will show the extent to which later social experience can compensate for early social experience or heritable factors in terms of adult social bonding success, the latter being a key factor in determining health and happiness in life. This project also offers the potential for using hormonal biomarkers in clincial settings, as objective assessment of changes in relationships over time, and in therapy by engaging in social behaviours that act as strong social hormone releasers.
Max ERC Funding
1 495 000 €
Duration
Start date: 2016-04-01, End date: 2021-03-31
Project acronym BAR2LEGAB
Project Women travelling to seek abortion care in Europe: the impact of barriers to legal abortion on women living in countries with ostensibly liberal abortion laws
Researcher (PI) Silvia De Zordo
Host Institution (HI) UNIVERSITAT DE BARCELONA
Call Details Starting Grant (StG), SH2, ERC-2015-STG
Summary In many European countries with ostensibly liberal abortion laws, women face legal restrictions to abortion beyond the first trimester of pregnancy, as well as other barriers to legal abortion, in particular shortages of providers willing and able to offer abortion due to poor training and to conscientious objection among physicians. The Council of Europe has recognized that conscientious objection can make access to safe abortion more difficult or impossible, particularly in rural areas and for low income women, who are forced to travel far to seek abortion care, including abroad. The WHO also highlights that delaying abortion care increases risks for women’s reproductive health. Despite the relevance of this topic from a public health and human rights perspective, the impact of procedural and social barriers to legal abortion on women in countries with ostensibly liberal abortion laws has not been studied by social scientists in Europe. This five-year research project is envisaged as a ground-breaking multi-disciplinary, mixed-methods investigation that will fill this gap, by capitalizing on previous, pioneer anthropological research of the PI on abortion and conscientious objection. It will contribute to the anthropology of reproduction in Europe, and particularly to the existing literature on abortion, conscientious objection and the medicalization of reproduction, and to the international debate on gender inequalities and citizenship, by exploring how barriers to legal abortion are constructed and how women embody and challenge them in different countries, by travelling or seeking illegal abortion, as well as their conceptualizations of abortion and their self perception as moral/political subjects. The project will be carried out in France, Italy and Spain, where the few existing studies show that women face several barriers to legal abortion as well as in the UK, the Netherlands and Spain, where Italian and French women travel to seek abortion care.
Summary
In many European countries with ostensibly liberal abortion laws, women face legal restrictions to abortion beyond the first trimester of pregnancy, as well as other barriers to legal abortion, in particular shortages of providers willing and able to offer abortion due to poor training and to conscientious objection among physicians. The Council of Europe has recognized that conscientious objection can make access to safe abortion more difficult or impossible, particularly in rural areas and for low income women, who are forced to travel far to seek abortion care, including abroad. The WHO also highlights that delaying abortion care increases risks for women’s reproductive health. Despite the relevance of this topic from a public health and human rights perspective, the impact of procedural and social barriers to legal abortion on women in countries with ostensibly liberal abortion laws has not been studied by social scientists in Europe. This five-year research project is envisaged as a ground-breaking multi-disciplinary, mixed-methods investigation that will fill this gap, by capitalizing on previous, pioneer anthropological research of the PI on abortion and conscientious objection. It will contribute to the anthropology of reproduction in Europe, and particularly to the existing literature on abortion, conscientious objection and the medicalization of reproduction, and to the international debate on gender inequalities and citizenship, by exploring how barriers to legal abortion are constructed and how women embody and challenge them in different countries, by travelling or seeking illegal abortion, as well as their conceptualizations of abortion and their self perception as moral/political subjects. The project will be carried out in France, Italy and Spain, where the few existing studies show that women face several barriers to legal abortion as well as in the UK, the Netherlands and Spain, where Italian and French women travel to seek abortion care.
Max ERC Funding
1 495 753 €
Duration
Start date: 2016-10-01, End date: 2021-09-30
Project acronym BBRhythms
Project Brain and body rhythms: on the relationship between movement and percept
Researcher (PI) Barbara Haendel
Host Institution (HI) JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG
Call Details Starting Grant (StG), SH4, ERC-2015-STG
Summary Exciting findings from animal electrophysiological research in the last years suggest that an increased rate of body movements results in an enhanced response of neurons within the visual system despite the absence of visual changes. It is unclear why such modulation occurs in areas which process visual input. In humans, little is known about the influence of body movements on sensory brain areas mainly due to the technical challenges of measuring brain responses during pronounced muscle activity. However, psychophysical studies in humans show that also percept and perceptual demands are connected to the rate of movements. These two lines of evidence suggest a general link between rhythmic body movements and perceptual processes.
The main aim of the proposed research is to decode the relationship between body movements and percept and to identify the underlying mechanism. To this end human non-invasive recordings from electro- and magnetoencephalography (EEG, MEG) as well as invasive human and animal multi-electrode recordings collected during movement execution will be analyzed. Directly relating perceptual processes and their underlying neuronal oscillations to rhythmic body movements offers an approach circumventing some of the methodological problems.
This research could uncover a new mechanism of how our system modulates perceptual processes through body movements. The proof of such a mechanism would constitute a ground-breaking step in understanding perception during natural behavior. We need to keep in mind that in the awake state our body is constantly in motion. However, up to now, the vast majority of studies which investigate sensory brain responses are conducted under strict movement suppression. Besides facilitating exciting new insights, this research can strengthen the assumption that the knowledge we have gathered about artificial situations generalizes to our natural behavior.
Summary
Exciting findings from animal electrophysiological research in the last years suggest that an increased rate of body movements results in an enhanced response of neurons within the visual system despite the absence of visual changes. It is unclear why such modulation occurs in areas which process visual input. In humans, little is known about the influence of body movements on sensory brain areas mainly due to the technical challenges of measuring brain responses during pronounced muscle activity. However, psychophysical studies in humans show that also percept and perceptual demands are connected to the rate of movements. These two lines of evidence suggest a general link between rhythmic body movements and perceptual processes.
The main aim of the proposed research is to decode the relationship between body movements and percept and to identify the underlying mechanism. To this end human non-invasive recordings from electro- and magnetoencephalography (EEG, MEG) as well as invasive human and animal multi-electrode recordings collected during movement execution will be analyzed. Directly relating perceptual processes and their underlying neuronal oscillations to rhythmic body movements offers an approach circumventing some of the methodological problems.
This research could uncover a new mechanism of how our system modulates perceptual processes through body movements. The proof of such a mechanism would constitute a ground-breaking step in understanding perception during natural behavior. We need to keep in mind that in the awake state our body is constantly in motion. However, up to now, the vast majority of studies which investigate sensory brain responses are conducted under strict movement suppression. Besides facilitating exciting new insights, this research can strengthen the assumption that the knowledge we have gathered about artificial situations generalizes to our natural behavior.
Max ERC Funding
1 422 907 €
Duration
Start date: 2016-07-01, End date: 2021-06-30
Project acronym BRISC
Project Bounded Rationality in Sensorimotor Coordination
Researcher (PI) Daniel Alexander Braun
Host Institution (HI) UNIVERSITAET ULM
Call Details Starting Grant (StG), SH4, ERC-2015-STG
Summary Despite their many successes and great computational power and speed, why are machines still so blatantly outperformed by humans in uncertain environments that require flexible sensorimotor behavior like playing football or navigating a disaster zone? Answering this question requires understanding the mathematical principles of biological sensorimotor control and learning. Over the recent years Bayes-optimal actor models have widely become the gold standard in the mathematical understanding of sensorimotor processing in well-controlled laboratory tasks. However, these models quickly become intractable for real-world problems because they ignore the computational effort required to search for the Bayes-optimum. What is therefore needed is a framework of sensorimotor processing that takes the limited information-processing capacity of bounded rational actors into account and that explains their robust real-world performance. It is the aim of BRISC to establish such a framework by drawing out theoretical predictions and gathering experimental evidence in human motor control, in particular to understand (i) how single bounded rational actors deviate from Bayes-optimal behavior in motor tasks, (ii) how multiple bounded rational actors organize themselves to solve motor tasks that no individual can solve by themselves and (iii) how this drives the emergence of hierarchical control structures that simultaneously process multiple degrees of abstraction at different time scales. Understanding how abstract concepts are formed autonomously from the sensorimotor stream based on resource allocation principles will establish an essential missing link between high-level symbolic and low-level perceptual processing. These advances will provide a decisive step towards a framework for robust and flexible sensorimotor processing, which is not only essential for understanding the fundamental principles of intelligent behavior, but it is also of potentially great technological value.
Summary
Despite their many successes and great computational power and speed, why are machines still so blatantly outperformed by humans in uncertain environments that require flexible sensorimotor behavior like playing football or navigating a disaster zone? Answering this question requires understanding the mathematical principles of biological sensorimotor control and learning. Over the recent years Bayes-optimal actor models have widely become the gold standard in the mathematical understanding of sensorimotor processing in well-controlled laboratory tasks. However, these models quickly become intractable for real-world problems because they ignore the computational effort required to search for the Bayes-optimum. What is therefore needed is a framework of sensorimotor processing that takes the limited information-processing capacity of bounded rational actors into account and that explains their robust real-world performance. It is the aim of BRISC to establish such a framework by drawing out theoretical predictions and gathering experimental evidence in human motor control, in particular to understand (i) how single bounded rational actors deviate from Bayes-optimal behavior in motor tasks, (ii) how multiple bounded rational actors organize themselves to solve motor tasks that no individual can solve by themselves and (iii) how this drives the emergence of hierarchical control structures that simultaneously process multiple degrees of abstraction at different time scales. Understanding how abstract concepts are formed autonomously from the sensorimotor stream based on resource allocation principles will establish an essential missing link between high-level symbolic and low-level perceptual processing. These advances will provide a decisive step towards a framework for robust and flexible sensorimotor processing, which is not only essential for understanding the fundamental principles of intelligent behavior, but it is also of potentially great technological value.
Max ERC Funding
1 434 250 €
Duration
Start date: 2016-10-01, End date: 2021-09-30
Project acronym cenRNA
Project The role of RNA in centromere biology and genome integrity
Researcher (PI) Sylvia Erhardt
Host Institution (HI) RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
Call Details Consolidator Grant (CoG), LS1, ERC-2015-CoG
Summary One of the most astonishing processes in the life of a cell is the division into two daughter cells. Such a highly organized process would presumably be regulated tightly by the underlying centromeric DNA sequence; however, the sites of chromosome attachment to the microtubule spindle are regulated by epigenetic mechanisms. The best-characterized epigenetic mark for centromeres is the histone H3-variant CENP-A, which replaces H3 in some of the nucleosomes within centromeric chromatin. Centromeres are embedded in pericentromeric heterochromatin and it has become apparent in recent years that heterochromatin is transcribed into non-coding RNAs. We have recently shown that a long non-coding RNA from pericentromeric heterochromatin of the X chromosome (SATIII) in Drosophila melanogaster localizes in trans to centromeres of all other chromosomes and is an essential component for correct loading and maintenance of CENP-A and, therefore, genome stability. Additional RNAs in Drosophila and RNAs from other species have been linked to centromeric chromatin, but their function is not understood. We propose that a complex, RNA-based epigenetic mechanism regulates centromere establishment and function.
This proposal is designed to the precise function of SATIII RNA by identifying the associated protein complexes as well as structural and post-transcriptional features of SATIII. We will evaluate the mechanisms by which SATIII functions as a heritable mark of centromeres through generations, during the developing germ line, and species separation. In parallel, we will systematically identify and characterize centromere-associated RNAs (cenRNAs) in Drosophila and human cells. We will elucidate their function in centromere biology and chromosome segregation, essentially as we have done and propose to do for SATIII. These experiments are designed to provide a detailed understanding of the essential, RNA-based epigenetic regulation of centromeres.
Summary
One of the most astonishing processes in the life of a cell is the division into two daughter cells. Such a highly organized process would presumably be regulated tightly by the underlying centromeric DNA sequence; however, the sites of chromosome attachment to the microtubule spindle are regulated by epigenetic mechanisms. The best-characterized epigenetic mark for centromeres is the histone H3-variant CENP-A, which replaces H3 in some of the nucleosomes within centromeric chromatin. Centromeres are embedded in pericentromeric heterochromatin and it has become apparent in recent years that heterochromatin is transcribed into non-coding RNAs. We have recently shown that a long non-coding RNA from pericentromeric heterochromatin of the X chromosome (SATIII) in Drosophila melanogaster localizes in trans to centromeres of all other chromosomes and is an essential component for correct loading and maintenance of CENP-A and, therefore, genome stability. Additional RNAs in Drosophila and RNAs from other species have been linked to centromeric chromatin, but their function is not understood. We propose that a complex, RNA-based epigenetic mechanism regulates centromere establishment and function.
This proposal is designed to the precise function of SATIII RNA by identifying the associated protein complexes as well as structural and post-transcriptional features of SATIII. We will evaluate the mechanisms by which SATIII functions as a heritable mark of centromeres through generations, during the developing germ line, and species separation. In parallel, we will systematically identify and characterize centromere-associated RNAs (cenRNAs) in Drosophila and human cells. We will elucidate their function in centromere biology and chromosome segregation, essentially as we have done and propose to do for SATIII. These experiments are designed to provide a detailed understanding of the essential, RNA-based epigenetic regulation of centromeres.
Max ERC Funding
1 896 250 €
Duration
Start date: 2016-07-01, End date: 2021-06-30
Project acronym CLOCK
Project CLIMATE ADAPTATION TO SHIFTING STOCKS
Researcher (PI) Elena Ojea
Host Institution (HI) UNIVERSIDAD DE VIGO
Call Details Starting Grant (StG), SH3, ERC-2015-STG
Summary Management of marine fisheries is still far from incorporating adaptation to climate change, even though global stocks are heavily overexploited and climate change is adding additional pressure to the resource. In fact, there is growing evidence that current fisheries management systems may no longer be effective under climate change, and this will translate into both ecological and socioeconomic impacts. This research project argues that the combination of fisheries management science and socio-ecological systems thinking is necessary in order to advance in fisheries adaptation to climate change. To this end, the main objectives are set to: 1) Identify and understand the new challenges raised by climate change for current sustainable fisheries management; 2) Develop a novel approach to fisheries adaptation within a socio-ecological framework; 3) Provide empirical evidence on potential solutions for the adaptation of fisheries management systems; and 4) Help introduce fisheries adaptation at the top of the regional and international adaptation policy agendas. To do this, I will combine model and simulation approaches to fisheries with specific case studies where both biophysical and economic variables will be studied an modelled, but also individuals will be given the opportunity to participate in an active way, learning from participatory methods their preferences towards adaptation and the consequences of the new scenarios climate change poses. Three potential case studies are identified for property rights over stocks, property rights over space, and Marine Reserves in two European and one international case study areas. As a result, I expect to develop a new Adaptation Framework for fisheries management that can be scalable, transferable and easily operationalized, and a set of case study examples on how to integrate theory and participatory processes with the aim of increasing social, ecological and institutional resilience to climate change.
Summary
Management of marine fisheries is still far from incorporating adaptation to climate change, even though global stocks are heavily overexploited and climate change is adding additional pressure to the resource. In fact, there is growing evidence that current fisheries management systems may no longer be effective under climate change, and this will translate into both ecological and socioeconomic impacts. This research project argues that the combination of fisheries management science and socio-ecological systems thinking is necessary in order to advance in fisheries adaptation to climate change. To this end, the main objectives are set to: 1) Identify and understand the new challenges raised by climate change for current sustainable fisheries management; 2) Develop a novel approach to fisheries adaptation within a socio-ecological framework; 3) Provide empirical evidence on potential solutions for the adaptation of fisheries management systems; and 4) Help introduce fisheries adaptation at the top of the regional and international adaptation policy agendas. To do this, I will combine model and simulation approaches to fisheries with specific case studies where both biophysical and economic variables will be studied an modelled, but also individuals will be given the opportunity to participate in an active way, learning from participatory methods their preferences towards adaptation and the consequences of the new scenarios climate change poses. Three potential case studies are identified for property rights over stocks, property rights over space, and Marine Reserves in two European and one international case study areas. As a result, I expect to develop a new Adaptation Framework for fisheries management that can be scalable, transferable and easily operationalized, and a set of case study examples on how to integrate theory and participatory processes with the aim of increasing social, ecological and institutional resilience to climate change.
Max ERC Funding
1 184 931 €
Duration
Start date: 2016-10-01, End date: 2021-09-30
Project acronym CondStruct
Project Structural basis for the coordination of chromosome architecture by condensin complexes
Researcher (PI) Christian Helmut Haering
Host Institution (HI) EUROPEAN MOLECULAR BIOLOGY LABORATORY
Call Details Consolidator Grant (CoG), LS1, ERC-2015-CoG
Summary Chromosomes undergo dramatic changes in their three-dimensional organisation during all aspects of genome function, ranging from the regulation of gene expression during cellular differentiation to chromosome duplication and partitioning over the course of a cell division cycle. The multi-subunit condensin protein complex plays major roles for these changes in DNA topology. Despite its fundamental importance, the mechanisms of condensin’s action are not understood.
Here, I propose a comprehensive research program that aims to reveal the elusive mechanisms behind the functions of the condensin complex. We intend to unravel how the condensin complex engages DNA, how this interaction activates large-scale ATPase-dependent conformational rearrangements within the complex, and how condensin eventually encircles chromatin fibres within its ring-shaped architecture. Insights from these mechanistic studies will be invaluable for understanding how networks of condensin-mediated linkages can shape linear DNA helices into higher-order chromosome structures. To achieve this ambitious and timely goal, we will combine an integrative structural biology approach with biochemical and cell biological methods. By applying complementary technologies, including X-ray protein crystallography, electron microscopy, cross-linking mass spectrometry, single molecule fluorescence microscopy and reconstitution experiments, we anticipate to build the first model of the entire condensin complex at near-atomic resolution and explain how dynamic conformational changes confer function.
The insights gained from this research program will provide an in-depth mechanistic comprehension of the core molecular machinery that determines the architecture of our genomes and will have major implications for understanding how genomic integrity is affected in various disease conditions.
Summary
Chromosomes undergo dramatic changes in their three-dimensional organisation during all aspects of genome function, ranging from the regulation of gene expression during cellular differentiation to chromosome duplication and partitioning over the course of a cell division cycle. The multi-subunit condensin protein complex plays major roles for these changes in DNA topology. Despite its fundamental importance, the mechanisms of condensin’s action are not understood.
Here, I propose a comprehensive research program that aims to reveal the elusive mechanisms behind the functions of the condensin complex. We intend to unravel how the condensin complex engages DNA, how this interaction activates large-scale ATPase-dependent conformational rearrangements within the complex, and how condensin eventually encircles chromatin fibres within its ring-shaped architecture. Insights from these mechanistic studies will be invaluable for understanding how networks of condensin-mediated linkages can shape linear DNA helices into higher-order chromosome structures. To achieve this ambitious and timely goal, we will combine an integrative structural biology approach with biochemical and cell biological methods. By applying complementary technologies, including X-ray protein crystallography, electron microscopy, cross-linking mass spectrometry, single molecule fluorescence microscopy and reconstitution experiments, we anticipate to build the first model of the entire condensin complex at near-atomic resolution and explain how dynamic conformational changes confer function.
The insights gained from this research program will provide an in-depth mechanistic comprehension of the core molecular machinery that determines the architecture of our genomes and will have major implications for understanding how genomic integrity is affected in various disease conditions.
Max ERC Funding
1 982 479 €
Duration
Start date: 2016-07-01, End date: 2021-06-30
Project acronym DECOR
Project Decorative Principles in late Republican and early Imperial Italy
Researcher (PI) Annette Adelheid Haug
Host Institution (HI) CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL
Call Details Consolidator Grant (CoG), SH5, ERC-2015-CoG
Summary This project will provide a comprehensive analysis of the decorative principles employed between the late Republic and the end of the early Imperial period, i.e. the 2nd century BC and the end of the 1st century AD. It will be the first research programme to move away from analyses of single decorative elements in isolation and to focus on their correlation and interaction. This comprehensive approach will be adopted for varying spatial contexts such as houses, sanctuaries and main streets, enabling analyses of the changes decorative principles underwent according to spatial and functional contexts. Within this framework, the project will address four core research questions:
(1) How can the interplay of different decorative elements be analysed for architecturally closed and open urban spaces? A key question here is how forms of decor interact on a formal level, as well as in terms of content and meaning, in order to create specific atmospheres.
(2) What methods allow a scientific assessment of the interplay between decor and the use of space?
(3) Is there a social significance to decorative principles? Do specific social groups or specific spatial contexts favour or exclusively employ specific forms of decor?
(4) How can decorative ensembles be identified as artistic expressions typical for certain periods?
This approach will enable analyses of forms of decor and their dependencies on respective functional contexts in spatial, chronological and social terms.
The project is a pilot project for advancing new methods in substantial analyses of decorated spaces. At the same time, it provides a fundamental advancement of our understanding of the visual culture from the late Republic to the early Roman Empire.
Summary
This project will provide a comprehensive analysis of the decorative principles employed between the late Republic and the end of the early Imperial period, i.e. the 2nd century BC and the end of the 1st century AD. It will be the first research programme to move away from analyses of single decorative elements in isolation and to focus on their correlation and interaction. This comprehensive approach will be adopted for varying spatial contexts such as houses, sanctuaries and main streets, enabling analyses of the changes decorative principles underwent according to spatial and functional contexts. Within this framework, the project will address four core research questions:
(1) How can the interplay of different decorative elements be analysed for architecturally closed and open urban spaces? A key question here is how forms of decor interact on a formal level, as well as in terms of content and meaning, in order to create specific atmospheres.
(2) What methods allow a scientific assessment of the interplay between decor and the use of space?
(3) Is there a social significance to decorative principles? Do specific social groups or specific spatial contexts favour or exclusively employ specific forms of decor?
(4) How can decorative ensembles be identified as artistic expressions typical for certain periods?
This approach will enable analyses of forms of decor and their dependencies on respective functional contexts in spatial, chronological and social terms.
The project is a pilot project for advancing new methods in substantial analyses of decorated spaces. At the same time, it provides a fundamental advancement of our understanding of the visual culture from the late Republic to the early Roman Empire.
Max ERC Funding
1 996 971 €
Duration
Start date: 2016-10-01, End date: 2021-09-30
Project acronym DevelopingTheatre
Project Developing Theatre: Building Expert Networks for Theatre in Emerging Countries after 1945
Researcher (PI) Christopher BALME
Host Institution (HI) LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Call Details Advanced Grant (AdG), SH5, ERC-2015-AdG
Summary This research project proposes a fundamental re-examination of the historiography of theatre in emerging countries after 1945 . It investigates the institutional factors that led to the emergence of professional theatre in the post-war period throughout the decolonizing world. The particular focus will be on the massive involvement of internationally coordinated ‘development’ and ‘modernization’ programs both East and West. The project will introduce the concepts of epistemic community, expert networks and techno-politics to theatre historical research as a means to historicize theatre within transnational and transcultural paradigms and examine its imbrication in globalization processes. This institutional and transnational approach will enable theatre studies to overcome its still strong national and local focus on plays and productions and connect it to current discourses on transnational history.
The main objectives of this project are to:
• examine how a global ‘epistemic community’ centred around theatre emerged in the post-war period;
• investigate how ‘expert networks’ composed of government bodies, private foundations, transnational corporate philanthropy, local elites and individual artists sought to institutionalize particular forms and practices of professional theatre as an interconnected, transnational phenomenon;
• develop a new interdisciplinary approach to theatre historiography by focusing on institutional structures, path dependencies and transnational imbrications rather than on works and authors.
The principal investigator will bring to this project two decades of internationally recognized research into intercultural and global theatre. With its combination of institutional historiography and innovative research methods the project will provide a new foundation for current discussions of cultural policy and sustainability in emerging societies.
Summary
This research project proposes a fundamental re-examination of the historiography of theatre in emerging countries after 1945 . It investigates the institutional factors that led to the emergence of professional theatre in the post-war period throughout the decolonizing world. The particular focus will be on the massive involvement of internationally coordinated ‘development’ and ‘modernization’ programs both East and West. The project will introduce the concepts of epistemic community, expert networks and techno-politics to theatre historical research as a means to historicize theatre within transnational and transcultural paradigms and examine its imbrication in globalization processes. This institutional and transnational approach will enable theatre studies to overcome its still strong national and local focus on plays and productions and connect it to current discourses on transnational history.
The main objectives of this project are to:
• examine how a global ‘epistemic community’ centred around theatre emerged in the post-war period;
• investigate how ‘expert networks’ composed of government bodies, private foundations, transnational corporate philanthropy, local elites and individual artists sought to institutionalize particular forms and practices of professional theatre as an interconnected, transnational phenomenon;
• develop a new interdisciplinary approach to theatre historiography by focusing on institutional structures, path dependencies and transnational imbrications rather than on works and authors.
The principal investigator will bring to this project two decades of internationally recognized research into intercultural and global theatre. With its combination of institutional historiography and innovative research methods the project will provide a new foundation for current discussions of cultural policy and sustainability in emerging societies.
Max ERC Funding
2 150 083 €
Duration
Start date: 2016-10-01, End date: 2021-09-30
