Project acronym COMPLEXITY
Project Understanding the Complexity of Modern Financial Systems
Researcher (PI) Vikrant Vig
Host Institution (HI) LONDON BUSINESS SCHOOL
Country United Kingdom
Call Details Starting Grant (StG), SH1, ERC-2015-STG
Summary The modern financial system has undergone immense transformation in recent years and is far more complex than ever before. In lockstep, financial regulation has also become more complex. This research proposal attempts to improve our understanding of potential drivers of this complexity and the implications of this change on the allocation of resources.
Taking a positive rather than a normative approach, I will analyse post-crisis changes at both the micro- and at the macro-levels to create a broader understanding of complexities in the current financial system. In order to do so, I will employ a set of advanced research designs, as well as a uniquely assembled micro-level dataset covering state and privately owned financial institutions in Asia, Africa, South America and Europe.
This project will focus on two interconnected areas of research: 1) Organisation of Credit, 2) Financial regulation in a complex environment. The aim of this project is to create a sustainable framework for the study of post-crisis financial systems, and to shape the current debate on the future of post-crisis financial structures and the development of policy in this area. Not only will this research have a considerable impact on our understanding of financial systems, it will also impact fields beyond finance, like Organisational Economics, Industrial Organisation and Development Economics.
Summary
The modern financial system has undergone immense transformation in recent years and is far more complex than ever before. In lockstep, financial regulation has also become more complex. This research proposal attempts to improve our understanding of potential drivers of this complexity and the implications of this change on the allocation of resources.
Taking a positive rather than a normative approach, I will analyse post-crisis changes at both the micro- and at the macro-levels to create a broader understanding of complexities in the current financial system. In order to do so, I will employ a set of advanced research designs, as well as a uniquely assembled micro-level dataset covering state and privately owned financial institutions in Asia, Africa, South America and Europe.
This project will focus on two interconnected areas of research: 1) Organisation of Credit, 2) Financial regulation in a complex environment. The aim of this project is to create a sustainable framework for the study of post-crisis financial systems, and to shape the current debate on the future of post-crisis financial structures and the development of policy in this area. Not only will this research have a considerable impact on our understanding of financial systems, it will also impact fields beyond finance, like Organisational Economics, Industrial Organisation and Development Economics.
Max ERC Funding
1 498 947 €
Duration
Start date: 2016-04-01, End date: 2021-03-31
Project acronym Coupled gene circuit
Project Dynamics, noise, and coupling in gene circuit modules
Researcher (PI) James Charles Wallace Locke
Host Institution (HI) THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Country United Kingdom
Call Details Starting Grant (StG), LS2, ERC-2013-StG
Summary Cells must integrate output from multiple genetic circuits in order to correctly control cellular processes. Despite much work characterizing regulation in these circuits, how circuits interact to control global cellular programs remains unclear. This is particularly true given that recent research at the single cell level has revealed that genetic circuits often generate variable or stochastic regulation dynamics. In this proposal we will use a multi-disciplinary approach, combining modelling and time-lapse microscopy, to investigate how cells can robustly integrate signals from multiple dynamic genetic circuits. In particular we will answer the following questions: 1) What types of dynamic signal encoding strategies are available for the cell? 2) What are the benefits of dynamic gene activation, whether stochastic or oscillatory, to the cell? 3) How do cells couple and integrate output from diverse gene modules despite the noise and variability observed in gene circuit dynamics?
We will study these questions using 2 key model systems. In Aim 1, we will examine stochastic pulse regulation dynamics and coupling between alternative sigma factors in B. subtilis. Our preliminary data has revealed that multiple B. subtilis sigma factors stochastically pulse under stress. We will look for evidence of any coupling or interactions between these stochastic pulse circuits. This system will serve as a model for how a cell uses stochastic pulsing to control diverse cellular processes. In Aim 2, we will examine coupling between a deterministic oscillator, the circadian clock, and multiple other key pathways in Cyanobacteria. We will examine how the cell can dynamically couple multiple cellular processes using an oscillating signal. This work will provide an excellent base for Aim 3, in which we will use synthetic biology approaches to develop ‘bottom up’ tests of generation of novel dynamic coupling strategies.
Summary
Cells must integrate output from multiple genetic circuits in order to correctly control cellular processes. Despite much work characterizing regulation in these circuits, how circuits interact to control global cellular programs remains unclear. This is particularly true given that recent research at the single cell level has revealed that genetic circuits often generate variable or stochastic regulation dynamics. In this proposal we will use a multi-disciplinary approach, combining modelling and time-lapse microscopy, to investigate how cells can robustly integrate signals from multiple dynamic genetic circuits. In particular we will answer the following questions: 1) What types of dynamic signal encoding strategies are available for the cell? 2) What are the benefits of dynamic gene activation, whether stochastic or oscillatory, to the cell? 3) How do cells couple and integrate output from diverse gene modules despite the noise and variability observed in gene circuit dynamics?
We will study these questions using 2 key model systems. In Aim 1, we will examine stochastic pulse regulation dynamics and coupling between alternative sigma factors in B. subtilis. Our preliminary data has revealed that multiple B. subtilis sigma factors stochastically pulse under stress. We will look for evidence of any coupling or interactions between these stochastic pulse circuits. This system will serve as a model for how a cell uses stochastic pulsing to control diverse cellular processes. In Aim 2, we will examine coupling between a deterministic oscillator, the circadian clock, and multiple other key pathways in Cyanobacteria. We will examine how the cell can dynamically couple multiple cellular processes using an oscillating signal. This work will provide an excellent base for Aim 3, in which we will use synthetic biology approaches to develop ‘bottom up’ tests of generation of novel dynamic coupling strategies.
Max ERC Funding
1 499 571 €
Duration
Start date: 2014-02-01, End date: 2019-01-31
Project acronym DYNAMICSS
Project Labour market dynamics and optimal policies
Researcher (PI) Camille Gregoire Alexis Landais
Host Institution (HI) LONDON SCHOOL OF ECONOMICS AND POLITICAL SCIENCE
Country United Kingdom
Call Details Starting Grant (StG), SH1, ERC-2015-STG
Summary From pension reforms to UI extensions, the optimal tax and program design literature is often ill-equipped to provide clear guidance in policy debates on the reform of social insurance and tax-and-benefit systems. The reason is that this literature is mostly focused on static settings, while these programs are inherently dynamic: they specify a schedule of tax and benefits that is time or state dependent and they affect individuals’ decisions throughout their lifetime.
DYNAMICSS will offer a simple and general approach to the analysis of optimal dynamic policies that connects to the data. The key idea of DYNAMICSS is to extend the sufficient statistics (SS) approach to dynamic settings and characterize the full time profile, rather than the average generosity, of social insurance and transfer policies. By expressing optimal policy as a function of a limited set of statistics, the SS approach has the advantage of making clear the trade-offs implied in optimal tax or benefit formulae and of tightly integrating the theory and the empirics of optimal policy analysis, to offer robust policy guidance.
DYNAMICSS will use unique administrative data and cutting-edge econometric techniques to exploit compelling variations in policy profiles and offer significant contributions to the empirical analysis of dynamic behavioural responses to policies. A central contribution will be to create a unique measure of consumption expenditures based on leveraging complete administrative information on income, transfers and wealth to offer ground-breaking evidence of the effect of social insurance on consumption dynamics.
Part I will use and extend the SS framework to analyse the optimal time profile of UI benefits. Part II will develop this approach for analysing the optimal design of retirement pension systems. Part III will address optimal family policies with a focus on understanding the different dynamics of men and women in the labour market, and exploring the role of cultural norm
Summary
From pension reforms to UI extensions, the optimal tax and program design literature is often ill-equipped to provide clear guidance in policy debates on the reform of social insurance and tax-and-benefit systems. The reason is that this literature is mostly focused on static settings, while these programs are inherently dynamic: they specify a schedule of tax and benefits that is time or state dependent and they affect individuals’ decisions throughout their lifetime.
DYNAMICSS will offer a simple and general approach to the analysis of optimal dynamic policies that connects to the data. The key idea of DYNAMICSS is to extend the sufficient statistics (SS) approach to dynamic settings and characterize the full time profile, rather than the average generosity, of social insurance and transfer policies. By expressing optimal policy as a function of a limited set of statistics, the SS approach has the advantage of making clear the trade-offs implied in optimal tax or benefit formulae and of tightly integrating the theory and the empirics of optimal policy analysis, to offer robust policy guidance.
DYNAMICSS will use unique administrative data and cutting-edge econometric techniques to exploit compelling variations in policy profiles and offer significant contributions to the empirical analysis of dynamic behavioural responses to policies. A central contribution will be to create a unique measure of consumption expenditures based on leveraging complete administrative information on income, transfers and wealth to offer ground-breaking evidence of the effect of social insurance on consumption dynamics.
Part I will use and extend the SS framework to analyse the optimal time profile of UI benefits. Part II will develop this approach for analysing the optimal design of retirement pension systems. Part III will address optimal family policies with a focus on understanding the different dynamics of men and women in the labour market, and exploring the role of cultural norm
Max ERC Funding
1 049 855 €
Duration
Start date: 2016-03-01, End date: 2021-02-28
Project acronym EMF-FEIM
Project Empirical Macro-Finance and the Financial Economics of Insurance Markets
Researcher (PI) Ralph Koijen
Host Institution (HI) LONDON BUSINESS SCHOOL
Country United Kingdom
Call Details Starting Grant (StG), SH1, ERC-2013-StG
Summary "My project consists of two lines of work. 1.Empirical Macro-Finance: Asset prices are informative about the macro-economic risks that matter to investors and about the welfare costs of economic fluctuations. However, recent empirical evidence suggests that leading asset pricing models cannot explain how risks are priced across maturities in equity markets, which is a key input to measuring the costs of business cycles. An analysis of what leading models miss will vastly improve our understanding of how the real economy and asset prices are related. Also, by expanding our empirical evidence about the term structure of equity to the firm-level, I plan to study how investment decisions relate to asset prices. My goal is to measure the firms' incentives to invest and how this impacts economic growth more broadly.
2.Financial Economics of Insurance Markets: Households in Europe and the US can choose from a wide variety of insurance products that insure health and mortality risks. Choosing between these products is no easy task and the costs from sub-optimal insurance choices are estimated to be large. My plan is to develop a comprehensive life-cycle theory of insurance choice that accounts for family structure, risk factors such as labor income and housing, and different institutional settings across countries. I also plan to study the supply side of insurance markets. The traditional view is that insurance prices are driven by life-cycle demand or informational frictions. However, as is clear from evidence during the financial crisis, insurance companies are in fact financial institutions. If financial constraints bind, it may affect insurance prices and ultimately consumers' welfare. My goal is to understand how financial frictions affect insurance companies. A policy implication of my research may be that the private supply of insurance is an imperfect substitute for public supply as insurance companies face different incentives and constraints than the government."
Summary
"My project consists of two lines of work. 1.Empirical Macro-Finance: Asset prices are informative about the macro-economic risks that matter to investors and about the welfare costs of economic fluctuations. However, recent empirical evidence suggests that leading asset pricing models cannot explain how risks are priced across maturities in equity markets, which is a key input to measuring the costs of business cycles. An analysis of what leading models miss will vastly improve our understanding of how the real economy and asset prices are related. Also, by expanding our empirical evidence about the term structure of equity to the firm-level, I plan to study how investment decisions relate to asset prices. My goal is to measure the firms' incentives to invest and how this impacts economic growth more broadly.
2.Financial Economics of Insurance Markets: Households in Europe and the US can choose from a wide variety of insurance products that insure health and mortality risks. Choosing between these products is no easy task and the costs from sub-optimal insurance choices are estimated to be large. My plan is to develop a comprehensive life-cycle theory of insurance choice that accounts for family structure, risk factors such as labor income and housing, and different institutional settings across countries. I also plan to study the supply side of insurance markets. The traditional view is that insurance prices are driven by life-cycle demand or informational frictions. However, as is clear from evidence during the financial crisis, insurance companies are in fact financial institutions. If financial constraints bind, it may affect insurance prices and ultimately consumers' welfare. My goal is to understand how financial frictions affect insurance companies. A policy implication of my research may be that the private supply of insurance is an imperfect substitute for public supply as insurance companies face different incentives and constraints than the government."
Max ERC Funding
1 077 765 €
Duration
Start date: 2013-10-01, End date: 2018-09-30
Project acronym FRICTIONS
Project Frictions in the Financial System
Researcher (PI) Peter Kondor
Host Institution (HI) LONDON SCHOOL OF ECONOMICS AND POLITICAL SCIENCE
Country United Kingdom
Call Details Starting Grant (StG), SH1, ERC-2013-StG
Summary "The financial crisis, since its start in 2008 has exposed enormous fractures both in the financial architecture and in the structure of the global economy. Although with some notable exceptions, the magnitude of the events caught the finance profession largely by surprise. Clearly, we have to understand better the institutional mechanism channeling savings towards the best uses of capital, and to what extent this mechanism can sometimes fail. The projects in this proposal will push the boundaries of our knowledge in this direction.
I suggest a dual approach to achieve this goal. First, we have to improve our understanding of which frictions are the crucial impediments of the efficient functioning of markets. As this approach focuses on particular markets in isolation, I call this the micro approach. I propose three projects within this approach: trading and information diffusion in OTC markets, the crowdedness in limits-to-arbitrage, and the interaction of political uncertainty and sovereign bond prices.
Second, from the frictions emerging from the micro approach, we have to select the ones which determine the aggregate liquidity fluctuations in the economy. I use this concept in a broad sense; referring to the changing efficiency with which the financial system allocates resources across investment opportunities. As this approach focuses on the functionality of the financial system as a whole, I call this the macro approach. I propose two projects within this approach. The first project focuses on the determinants of the differences in the financial architecture of different economies. It builds a novel framework to study the dynamics of the financial sector of an economy. The second project studies the role of shadow banking in the fluctuation of aggregate liquidity. In particular, this project concentrates on the fluctuation of the efficiency of private liquidity creation as the state of the economy changes."
Summary
"The financial crisis, since its start in 2008 has exposed enormous fractures both in the financial architecture and in the structure of the global economy. Although with some notable exceptions, the magnitude of the events caught the finance profession largely by surprise. Clearly, we have to understand better the institutional mechanism channeling savings towards the best uses of capital, and to what extent this mechanism can sometimes fail. The projects in this proposal will push the boundaries of our knowledge in this direction.
I suggest a dual approach to achieve this goal. First, we have to improve our understanding of which frictions are the crucial impediments of the efficient functioning of markets. As this approach focuses on particular markets in isolation, I call this the micro approach. I propose three projects within this approach: trading and information diffusion in OTC markets, the crowdedness in limits-to-arbitrage, and the interaction of political uncertainty and sovereign bond prices.
Second, from the frictions emerging from the micro approach, we have to select the ones which determine the aggregate liquidity fluctuations in the economy. I use this concept in a broad sense; referring to the changing efficiency with which the financial system allocates resources across investment opportunities. As this approach focuses on the functionality of the financial system as a whole, I call this the macro approach. I propose two projects within this approach. The first project focuses on the determinants of the differences in the financial architecture of different economies. It builds a novel framework to study the dynamics of the financial sector of an economy. The second project studies the role of shadow banking in the fluctuation of aggregate liquidity. In particular, this project concentrates on the fluctuation of the efficiency of private liquidity creation as the state of the economy changes."
Max ERC Funding
1 122 883 €
Duration
Start date: 2013-12-01, End date: 2018-11-30
Project acronym HISKNOWL
Project Using Historical Quasi-Experiments to Understand the Knowledge Economy
Researcher (PI) Fabian Waldinger
Host Institution (HI) LONDON SCHOOL OF ECONOMICS AND POLITICAL SCIENCE
Country United Kingdom
Call Details Starting Grant (StG), SH1, ERC-2013-StG
Summary This proposal covers three research strands at the intersection of innovation economics, economic history, and labour economics.
In project A I will investigate how the number of entrepreneurs at the city level affects city growth. As the number of entrepreneurs in a city is likely to be endogenous I identify the causal effect of entrepreneurs using the exodus of Jewish entrepreneurs from German cities during the Nazi era. As different German cities were affected to varying extents by the exodus of Jewish entrepreneurs I can investigate how entrepreneurs affect local GDP and employment in the long-run. Furthermore, I will analyse which types of entrepreneurs matter (e.g. bankers versus manufacturers) because different cities lost Jewish entrepreneurs in different professions.
In project B we will analyse how increases in the availability of secondary schools in Germany affect the number of talented people (such as scientists, parliamentarians or entrepreneurs) who originate from certain cities. To analyse the causal effect of secondary school availability we study large expansions in the number of schools in Germany that lowered the cost of attending an academic-track school for children in some locations, in particular for students in rural areas. Furthermore, we will investigate how the school curriculum and how single-sex versus mixed-sex education affect the production of talent.
In project C we investigate the role of open science for the accumulation of knowledge. To investigate the causal effect of open science on the productivity of scientists we will investigate the exclusion of scientists from the losing Central Powers (e.g. Germany) from the international scientific community after WWI. As the exclusion affected scientists in different scientific fields and countries very differently we can identify the role of open science for the number of published articles by a certain scientist and how quickly she cites important work by foreign scientists.
Summary
This proposal covers three research strands at the intersection of innovation economics, economic history, and labour economics.
In project A I will investigate how the number of entrepreneurs at the city level affects city growth. As the number of entrepreneurs in a city is likely to be endogenous I identify the causal effect of entrepreneurs using the exodus of Jewish entrepreneurs from German cities during the Nazi era. As different German cities were affected to varying extents by the exodus of Jewish entrepreneurs I can investigate how entrepreneurs affect local GDP and employment in the long-run. Furthermore, I will analyse which types of entrepreneurs matter (e.g. bankers versus manufacturers) because different cities lost Jewish entrepreneurs in different professions.
In project B we will analyse how increases in the availability of secondary schools in Germany affect the number of talented people (such as scientists, parliamentarians or entrepreneurs) who originate from certain cities. To analyse the causal effect of secondary school availability we study large expansions in the number of schools in Germany that lowered the cost of attending an academic-track school for children in some locations, in particular for students in rural areas. Furthermore, we will investigate how the school curriculum and how single-sex versus mixed-sex education affect the production of talent.
In project C we investigate the role of open science for the accumulation of knowledge. To investigate the causal effect of open science on the productivity of scientists we will investigate the exclusion of scientists from the losing Central Powers (e.g. Germany) from the international scientific community after WWI. As the exclusion affected scientists in different scientific fields and countries very differently we can identify the role of open science for the number of published articles by a certain scientist and how quickly she cites important work by foreign scientists.
Max ERC Funding
733 621 €
Duration
Start date: 2013-11-01, End date: 2018-09-30
Project acronym InterMetrix
Project Econometric Analysis of Interaction Models
Researcher (PI) Aureo Nilo De Paula Neto
Host Institution (HI) University College London
Country United Kingdom
Call Details Starting Grant (StG), SH1, ERC-2013-StG
Summary Equilibrium models are one of the pillars of Economics. This proposal focuses on methodological and empirical studies of estimable game theoretic and social interactions models where observed outcomes are assumed to be determined in equilibrium. Ignoring this simultaneity in estimation and inference is likely to mislead conclusions and produce flawed counterfactual analyses.
One pervasive feature in many interaction models is the existence of multiple solutions for various payoff configurations, and this is an aspect that carries over to estimable versions of such systems. Overlooking this possibility or assuming an uninformed equilibrium selection process potentially opens the door to severe misspecifications and erroneous conclusions. Another notable complication in the analysis of interaction models is computability: with a large number of players and sizeable set of outcomes and/or states, the search for an equilibrium solution can be daunting.
The research projects contemplated in this proposal address one or both of these aspects in various different settings. Those projects contain methodological and substantive contributions. The work involves advances in the econometric analysis (identification and estimation) of interaction models and empirical implementation of the devised methodologies to questions of interest. Given the widespread and increasing use of such econometric models, the projects contemplated here will have a fundamental impact.
I divide the projects into three main subtopics:
1) Identification and inference in games with multiple equilibria,
2) Social interactions and network models,
3) Dynamic interaction models.
Summary
Equilibrium models are one of the pillars of Economics. This proposal focuses on methodological and empirical studies of estimable game theoretic and social interactions models where observed outcomes are assumed to be determined in equilibrium. Ignoring this simultaneity in estimation and inference is likely to mislead conclusions and produce flawed counterfactual analyses.
One pervasive feature in many interaction models is the existence of multiple solutions for various payoff configurations, and this is an aspect that carries over to estimable versions of such systems. Overlooking this possibility or assuming an uninformed equilibrium selection process potentially opens the door to severe misspecifications and erroneous conclusions. Another notable complication in the analysis of interaction models is computability: with a large number of players and sizeable set of outcomes and/or states, the search for an equilibrium solution can be daunting.
The research projects contemplated in this proposal address one or both of these aspects in various different settings. Those projects contain methodological and substantive contributions. The work involves advances in the econometric analysis (identification and estimation) of interaction models and empirical implementation of the devised methodologies to questions of interest. Given the widespread and increasing use of such econometric models, the projects contemplated here will have a fundamental impact.
I divide the projects into three main subtopics:
1) Identification and inference in games with multiple equilibria,
2) Social interactions and network models,
3) Dynamic interaction models.
Max ERC Funding
1 028 780 €
Duration
Start date: 2013-10-01, End date: 2018-09-30
Project acronym MACRONETS
Project Production Networks in Macroeconomics
Researcher (PI) Vasco Pereira Marques De Carvalho
Host Institution (HI) THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Country United Kingdom
Call Details Starting Grant (StG), SH1, ERC-2013-StG
Summary "A modern economy is an intricately linked web of specialized production units, each relying on the flow of inputs from their suppliers to produce their own output which, in turn, is routed towards other downstream units. Recent work in economics stresses that the structure of this production network is key in determining whether and how microeconomic shocks can propagate throughout the economy and shape aggregate outcomes.
This project has two main goals. First, it aims to provide novel evidence that we can trace back the origins of business cycles and asset price fluctuations to individual technologies interconnected by input-supply relations. The particular questions it tries to answer are: (1) Can we have more direct, causal, evidence that these micro shocks do matter in practice for the evolution of aggregates? What are examples of these micro shocks in reality, how can we identify them and how do they propagate through input chains? (2) What are the asset pricing implications of this perspective on the micro origins of aggregate fluctuations? What is the relation between changes in the technology portfolio of an economy and the evolution of asset prices?
The second aim of this project is to improve our understanding of the structure and evolution of these production networks by asking the following questions: (3) At the firm level, do more productive suppliers match with more productive customers and, if so, why? What is the typical duration of a supplier-customer match and does this vary across matches? What is the firm-level impact of matching with better suppliers or more productive customers? (4) How do inputs diffuse on a network of interconnected technologies? Do linkages across sectors facilitate input adoption and the diffusion of General Purpose Technologies? Can linkages across sectors help us understand not only which sectors will adopt a given input but also the order in which these sectors adopt it?"
Summary
"A modern economy is an intricately linked web of specialized production units, each relying on the flow of inputs from their suppliers to produce their own output which, in turn, is routed towards other downstream units. Recent work in economics stresses that the structure of this production network is key in determining whether and how microeconomic shocks can propagate throughout the economy and shape aggregate outcomes.
This project has two main goals. First, it aims to provide novel evidence that we can trace back the origins of business cycles and asset price fluctuations to individual technologies interconnected by input-supply relations. The particular questions it tries to answer are: (1) Can we have more direct, causal, evidence that these micro shocks do matter in practice for the evolution of aggregates? What are examples of these micro shocks in reality, how can we identify them and how do they propagate through input chains? (2) What are the asset pricing implications of this perspective on the micro origins of aggregate fluctuations? What is the relation between changes in the technology portfolio of an economy and the evolution of asset prices?
The second aim of this project is to improve our understanding of the structure and evolution of these production networks by asking the following questions: (3) At the firm level, do more productive suppliers match with more productive customers and, if so, why? What is the typical duration of a supplier-customer match and does this vary across matches? What is the firm-level impact of matching with better suppliers or more productive customers? (4) How do inputs diffuse on a network of interconnected technologies? Do linkages across sectors facilitate input adoption and the diffusion of General Purpose Technologies? Can linkages across sectors help us understand not only which sectors will adopt a given input but also the order in which these sectors adopt it?"
Max ERC Funding
940 200 €
Duration
Start date: 2014-05-01, End date: 2019-04-30
Project acronym NanoScope
Project Optical imaging of nanoscopic dynamics and potentials
Researcher (PI) Philipp Kukura
Host Institution (HI) THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Country United Kingdom
Call Details Starting Grant (StG), LS1, ERC-2013-StG
Summary I propose to develop and apply a novel approach to optical microscopy to enable the direct visualization and study of dynamics on the nanoscale in biological and condensed matter physics. Given the speed with which nanoscopic objects move at ambient condition, this requires simultaneously very fast (ms) and precise (nm) imaging. The challenge is to avoid excessive perturbation of the system and enable imaging in biologically compatible environments without compromising imaging performance by pushing interferometric scattering to its theoretical limits.
Using these advanced capabilities, I will study the dynamics and thereby the structure-function relationships in three fundamental systems that are currently not captured by even the most advanced biophysical approaches. These include: (1) the flexibility of DNA on short length scales, (2) diffusion in artificial and cellular membranes and (3) the three-dimensional power stroke of molecular motors such as myosin and kinesin.
Fundamentally, this work aims to develop and establish a high-speed, non-invasive camera on the nanoscale that will enable us to study and eventually understand nanoscopic motion, dynamics and potentials on the relevant, rather than currently achievable, size and time scales.
Summary
I propose to develop and apply a novel approach to optical microscopy to enable the direct visualization and study of dynamics on the nanoscale in biological and condensed matter physics. Given the speed with which nanoscopic objects move at ambient condition, this requires simultaneously very fast (ms) and precise (nm) imaging. The challenge is to avoid excessive perturbation of the system and enable imaging in biologically compatible environments without compromising imaging performance by pushing interferometric scattering to its theoretical limits.
Using these advanced capabilities, I will study the dynamics and thereby the structure-function relationships in three fundamental systems that are currently not captured by even the most advanced biophysical approaches. These include: (1) the flexibility of DNA on short length scales, (2) diffusion in artificial and cellular membranes and (3) the three-dimensional power stroke of molecular motors such as myosin and kinesin.
Fundamentally, this work aims to develop and establish a high-speed, non-invasive camera on the nanoscale that will enable us to study and eventually understand nanoscopic motion, dynamics and potentials on the relevant, rather than currently achievable, size and time scales.
Max ERC Funding
1 498 352 €
Duration
Start date: 2014-01-01, End date: 2018-12-31
Project acronym NeuroVisEco
Project Zebrafish vision in its natural context: from natural scenes through retinal and central processing to behaviour.
Researcher (PI) Thomas Baden
Host Institution (HI) THE UNIVERSITY OF SUSSEX
Country United Kingdom
Call Details Starting Grant (StG), LS5, ERC-2015-STG
Summary All visual systems are specialised to best serve an animal’s sensory niche, yet how such specialisations are achieved through phylogenetic and developmental adaptations of the ‘common vertebrate visual system blueprint’ are poorly understood. I will study these adaptations in the visual system of zebrafish. I will use two-photon functional imaging and computational modelling to investigate how the visual system of zebrafish samples and processes behaviourally meaningful stimuli in the natural world. I will then use optogenetic manipulations while zebrafish navigate a virtual reality environment to directly probe the role of visual circuits in driving behaviour. Specifically, I will pursue four Aims:
1. What is the zebrafish eye designed to see?
2. How does the fish retina form feature selective output channels?
3. What does the fish’s eye tell the fish’s brain?
4. How does visual input to the brain lead to behaviour?
Visual specialisations begin in the optics and movements of the eyes, and are subsequently deeply rooted in every step of neuronal computation. Therefore, I will study visual processing at these different organisational levels. Here, the highly ‘visual’ zebrafish present a powerful model. They (i) offer exquisite genetic tools to record and manipulate neurons, (ii) have transparent larval stages permitting optical access to the entire nervous system and (iii) there is a large array of well-studied and easily quantifiable visual behaviours. In addition, zebrafish undergo two distinct life-stages, from larva to adult - with distinct lifestyles in different visual environments and hence different feature-detection requirements. Comparison of processing strategies employed by the (a) larval and (b) adult zebrafish visual system with that of other species, including a complementary database already recorded in mice (c), will lead to an increasingly generalised understanding of biological vision.
Summary
All visual systems are specialised to best serve an animal’s sensory niche, yet how such specialisations are achieved through phylogenetic and developmental adaptations of the ‘common vertebrate visual system blueprint’ are poorly understood. I will study these adaptations in the visual system of zebrafish. I will use two-photon functional imaging and computational modelling to investigate how the visual system of zebrafish samples and processes behaviourally meaningful stimuli in the natural world. I will then use optogenetic manipulations while zebrafish navigate a virtual reality environment to directly probe the role of visual circuits in driving behaviour. Specifically, I will pursue four Aims:
1. What is the zebrafish eye designed to see?
2. How does the fish retina form feature selective output channels?
3. What does the fish’s eye tell the fish’s brain?
4. How does visual input to the brain lead to behaviour?
Visual specialisations begin in the optics and movements of the eyes, and are subsequently deeply rooted in every step of neuronal computation. Therefore, I will study visual processing at these different organisational levels. Here, the highly ‘visual’ zebrafish present a powerful model. They (i) offer exquisite genetic tools to record and manipulate neurons, (ii) have transparent larval stages permitting optical access to the entire nervous system and (iii) there is a large array of well-studied and easily quantifiable visual behaviours. In addition, zebrafish undergo two distinct life-stages, from larva to adult - with distinct lifestyles in different visual environments and hence different feature-detection requirements. Comparison of processing strategies employed by the (a) larval and (b) adult zebrafish visual system with that of other species, including a complementary database already recorded in mice (c), will lead to an increasingly generalised understanding of biological vision.
Max ERC Funding
1 500 000 €
Duration
Start date: 2016-06-01, End date: 2021-05-31