Project acronym AXIAL.EC
Project PRINCIPLES OF AXIAL POLARITY-DRIVEN VASCULAR PATTERNING
Researcher (PI) Claudio Franco
Host Institution (HI) INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES
Country Portugal
Call Details Starting Grant (StG), LS4, ERC-2015-STG
Summary The formation of a functional patterned vascular network is essential for development, tissue growth and organ physiology. Several human vascular disorders arise from the mis-patterning of blood vessels, such as arteriovenous malformations, aneurysms and diabetic retinopathy. Although blood flow is recognised as a stimulus for vascular patterning, very little is known about the molecular mechanisms that regulate endothelial cell behaviour in response to flow and promote vascular patterning.
Recently, we uncovered that endothelial cells migrate extensively in the immature vascular network, and that endothelial cells polarise against the blood flow direction. Here, we put forward the hypothesis that vascular patterning is dependent on the polarisation and migration of endothelial cells against the flow direction, in a continuous flux of cells going from low-shear stress to high-shear stress regions. We will establish new reporter mouse lines to observe and manipulate endothelial polarity in vivo in order to investigate how polarisation and coordination of endothelial cells movements are orchestrated to generate vascular patterning. We will manipulate cell polarity using mouse models to understand the importance of cell polarisation in vascular patterning. Also, using a unique zebrafish line allowing analysis of endothelial cell polarity, we will perform a screen to identify novel regulators of vascular patterning. Finally, we will explore the hypothesis that defective flow-dependent endothelial polarisation underlies arteriovenous malformations using two genetic models.
This integrative approach, based on high-resolution imaging and unique experimental models, will provide a unifying model defining the cellular and molecular principles involved in vascular patterning. Given the physiological relevance of vascular patterning in health and disease, this research plan will set the basis for the development of novel clinical therapies targeting vascular disorders.
Summary
The formation of a functional patterned vascular network is essential for development, tissue growth and organ physiology. Several human vascular disorders arise from the mis-patterning of blood vessels, such as arteriovenous malformations, aneurysms and diabetic retinopathy. Although blood flow is recognised as a stimulus for vascular patterning, very little is known about the molecular mechanisms that regulate endothelial cell behaviour in response to flow and promote vascular patterning.
Recently, we uncovered that endothelial cells migrate extensively in the immature vascular network, and that endothelial cells polarise against the blood flow direction. Here, we put forward the hypothesis that vascular patterning is dependent on the polarisation and migration of endothelial cells against the flow direction, in a continuous flux of cells going from low-shear stress to high-shear stress regions. We will establish new reporter mouse lines to observe and manipulate endothelial polarity in vivo in order to investigate how polarisation and coordination of endothelial cells movements are orchestrated to generate vascular patterning. We will manipulate cell polarity using mouse models to understand the importance of cell polarisation in vascular patterning. Also, using a unique zebrafish line allowing analysis of endothelial cell polarity, we will perform a screen to identify novel regulators of vascular patterning. Finally, we will explore the hypothesis that defective flow-dependent endothelial polarisation underlies arteriovenous malformations using two genetic models.
This integrative approach, based on high-resolution imaging and unique experimental models, will provide a unifying model defining the cellular and molecular principles involved in vascular patterning. Given the physiological relevance of vascular patterning in health and disease, this research plan will set the basis for the development of novel clinical therapies targeting vascular disorders.
Max ERC Funding
1 618 750 €
Duration
Start date: 2016-09-01, End date: 2022-02-28
Project acronym BlackBox
Project A collaborative platform to document performance composition: from conceptual structures in the backstage to customizable visualizations in the front-end
Researcher (PI) Carla Maria De Jesus Fernandes
Host Institution (HI) FACULDADE DE CIENCIAS SOCIAIS E HUMANAS DA UNIVERSIDADE NOVA DE LISBOA
Country Portugal
Call Details Starting Grant (StG), SH5, ERC-2013-StG
Summary The global performing arts community is requiring innovative systems to: a) document, transmit and preserve the knowledge contained in choreographic-dramaturgic practices; b) assist artists with tools to facilitate their compositional processes, preferably on a collaborative basis. The existing digital archives of performing arts mostly function as conventional e-libraries, not allowing higher degrees of interactivity or active user intervention. They rarely contemplate accessible video annotation tools or provide relational querying functionalities based on artist-driven conceptual principles or idiosyncratic ontologies.
This proposal endeavours to fill that gap and create a new paradigm for the documentation of performance composition. It aims at the analysis of artists’ unique conceptual structures, by combining the empirical insights of contemporary creators with research theories from Multimodal Communication and Digital Media studies. The challenge is to design a model for a web-based collaborative platform enabling both a robust representation of performance composition methods and novel visualization technologies to support it. This can be done by analysing recurring body movement patterns and by fostering online contributions of users (a.o. performers and researchers) to the multimodal annotations stored in the platform. To accomplish this goal, two subjacent components must be developed: 1. the production of a video annotation-tool to allow artists in rehearsal periods to take notes over video in real-time and share them via the collaborative platform; 2. the linguistic analysis of a corpus of invited artists’ multimodal materials as source for the extraction of indicative conceptual structures, which will guide the architectural logics and interface design of the collaborative platform software.The outputs of these two components will generate critical case-studies to help understanding the human mind when engaged in cultural production processes.
Summary
The global performing arts community is requiring innovative systems to: a) document, transmit and preserve the knowledge contained in choreographic-dramaturgic practices; b) assist artists with tools to facilitate their compositional processes, preferably on a collaborative basis. The existing digital archives of performing arts mostly function as conventional e-libraries, not allowing higher degrees of interactivity or active user intervention. They rarely contemplate accessible video annotation tools or provide relational querying functionalities based on artist-driven conceptual principles or idiosyncratic ontologies.
This proposal endeavours to fill that gap and create a new paradigm for the documentation of performance composition. It aims at the analysis of artists’ unique conceptual structures, by combining the empirical insights of contemporary creators with research theories from Multimodal Communication and Digital Media studies. The challenge is to design a model for a web-based collaborative platform enabling both a robust representation of performance composition methods and novel visualization technologies to support it. This can be done by analysing recurring body movement patterns and by fostering online contributions of users (a.o. performers and researchers) to the multimodal annotations stored in the platform. To accomplish this goal, two subjacent components must be developed: 1. the production of a video annotation-tool to allow artists in rehearsal periods to take notes over video in real-time and share them via the collaborative platform; 2. the linguistic analysis of a corpus of invited artists’ multimodal materials as source for the extraction of indicative conceptual structures, which will guide the architectural logics and interface design of the collaborative platform software.The outputs of these two components will generate critical case-studies to help understanding the human mind when engaged in cultural production processes.
Max ERC Funding
1 378 200 €
Duration
Start date: 2014-05-01, End date: 2019-04-30
Project acronym CAPSAHARA
Project CRITICAL APPROACHES TO POLITICS, SOCIAL ACTIVISM, AND ISLAMIC MILITANCY IN THE WESTERN SAHARAN REGION
Researcher (PI) Francisco Manuel Machado da Rosa da Silva Freire
Host Institution (HI) CENTRO EM REDE DE INVESTIGACAO EM ANTROPOLOGIA
Country Portugal
Call Details Starting Grant (StG), SH5, ERC-2016-STG
Summary This project proposes an analysis of the reconfigurations established in the socio-political vocabulary of the western Saharan region – southern Morocco, Western Sahara and Mauritania – from the “post-empire” to the contemporary period. The project should produce an analysis of 1) the social and political structures shared in the region, 2) the local variations of those structures, based on case studies, 3) their specific configurations, based on social markers such as gender, age, and class, 4) the use of those structures in different historical periods. All these will be under theoretical and ethnographic scrutiny in order to achieve its main goal: 5) to understand the recent articulation of the social and political structures of the Western Saharan region, with broader and often exogenous political vocabularies.
The methodology used in this project is based on readings associated with different social sciences, with a particular focus on anthropology, history, and political science. The members of the research team, with experience and linguistic competence in the different geographies involved in this project, are expected to conduct original field enquiries, enabling a significant enhancement of the theoretical and ethnographic knowledge associated with this region.
The project’s main goal is to analyse the types of interplay established between pre-modern socio-political traditions and contemporary political expression and activism, in a particularly sensitive – and academically disregarded – region. Its effort to integrate a context that is usually compartmentalized, as well as to put together a group of researchers generally “isolated” in their particular areas of expertise, geographies, or nations, should also be valued. The project’s results should enable the different contexts under study to be integrated into the wider maps of current scientific research, providing, at the same time a dissemination of its outputs to an extended audience.
Summary
This project proposes an analysis of the reconfigurations established in the socio-political vocabulary of the western Saharan region – southern Morocco, Western Sahara and Mauritania – from the “post-empire” to the contemporary period. The project should produce an analysis of 1) the social and political structures shared in the region, 2) the local variations of those structures, based on case studies, 3) their specific configurations, based on social markers such as gender, age, and class, 4) the use of those structures in different historical periods. All these will be under theoretical and ethnographic scrutiny in order to achieve its main goal: 5) to understand the recent articulation of the social and political structures of the Western Saharan region, with broader and often exogenous political vocabularies.
The methodology used in this project is based on readings associated with different social sciences, with a particular focus on anthropology, history, and political science. The members of the research team, with experience and linguistic competence in the different geographies involved in this project, are expected to conduct original field enquiries, enabling a significant enhancement of the theoretical and ethnographic knowledge associated with this region.
The project’s main goal is to analyse the types of interplay established between pre-modern socio-political traditions and contemporary political expression and activism, in a particularly sensitive – and academically disregarded – region. Its effort to integrate a context that is usually compartmentalized, as well as to put together a group of researchers generally “isolated” in their particular areas of expertise, geographies, or nations, should also be valued. The project’s results should enable the different contexts under study to be integrated into the wider maps of current scientific research, providing, at the same time a dissemination of its outputs to an extended audience.
Max ERC Funding
1 192 144 €
Duration
Start date: 2017-04-01, End date: 2021-12-31
Project acronym ContentMAP
Project Contentotopic mapping: the topographical organization of object knowledge in the brain
Researcher (PI) Jorge ALMEIDA
Host Institution (HI) UNIVERSIDADE DE COIMBRA
Country Portugal
Call Details Starting Grant (StG), SH4, ERC-2018-STG
Summary Our ability to recognize an object amongst many others is one of the most important features of the human mind. However, object recognition requires tremendous computational effort, as we need to solve a complex and recursive environment with ease and proficiency. This challenging feat is dependent on the implementation of an effective organization of knowledge in the brain. In ContentMAP I will put forth a novel understanding of how object knowledge is organized in the brain, by proposing that this knowledge is topographically laid out in the cortical surface according to object-related dimensions that code for different types of representational content – I will call this contentotopic mapping. To study this fine-grain topography, I will use a combination of fMRI, behavioral, and neuromodulation approaches. I will first obtain patterns of neural and cognitive similarity between objects, and from these extract object-related dimensions using a dimensionality reduction technique. I will then parametrically manipulate these dimensions with an innovative use of a visual field mapping technique, and test how functional selectivity changes across the cortical surface according to an object’s score on a target dimension. Moreover, I will test the tuning function of these contentotopic maps. Finally, to mirror the complexity of implementing a high-dimensional manifold onto a 2D cortical sheet, I will aggregate the topographies for the different dimensions into a composite map, and develop an encoding model to predict neural signatures for each object. To sum up, ContentMAP will have a dramatic impact in the cognitive sciences by describing how the stuff of concepts is represented in the brain, and providing a complete description of how fine-grain representations and functional selectivity within high-level complex processes are topographically implemented.
Summary
Our ability to recognize an object amongst many others is one of the most important features of the human mind. However, object recognition requires tremendous computational effort, as we need to solve a complex and recursive environment with ease and proficiency. This challenging feat is dependent on the implementation of an effective organization of knowledge in the brain. In ContentMAP I will put forth a novel understanding of how object knowledge is organized in the brain, by proposing that this knowledge is topographically laid out in the cortical surface according to object-related dimensions that code for different types of representational content – I will call this contentotopic mapping. To study this fine-grain topography, I will use a combination of fMRI, behavioral, and neuromodulation approaches. I will first obtain patterns of neural and cognitive similarity between objects, and from these extract object-related dimensions using a dimensionality reduction technique. I will then parametrically manipulate these dimensions with an innovative use of a visual field mapping technique, and test how functional selectivity changes across the cortical surface according to an object’s score on a target dimension. Moreover, I will test the tuning function of these contentotopic maps. Finally, to mirror the complexity of implementing a high-dimensional manifold onto a 2D cortical sheet, I will aggregate the topographies for the different dimensions into a composite map, and develop an encoding model to predict neural signatures for each object. To sum up, ContentMAP will have a dramatic impact in the cognitive sciences by describing how the stuff of concepts is represented in the brain, and providing a complete description of how fine-grain representations and functional selectivity within high-level complex processes are topographically implemented.
Max ERC Funding
1 816 004 €
Duration
Start date: 2019-02-01, End date: 2024-01-31
Project acronym CROME
Project Crossed Memories, Politics of Silence: The Colonial-Liberation Wars in Postcolonial Times
Researcher (PI) Miguel Goncalo CARDINA
Host Institution (HI) CENTRO DE ESTUDOS SOCIAIS
Country Portugal
Call Details Starting Grant (StG), SH6, ERC-2016-STG
Summary Colonial-Liberation Wars generate plural memories, conflicting evocations and persisting amnesias. The project’s main challenge is to produce innovative knowledge about the memories of the wars fought by the Portuguese state and pro-independence African movements between 1961 and 1974/5. The approach chosen is simultaneously diachronic and comparative, inasmuch as it contrasts changes that took place between the end of the conflicts and nowadays, regarding how wars, colonial pasts and anticolonial legacies have been remembered and silenced in Portugal, Angola, Mozambique, Guinea-Bissau, Cape Verde and São Tomé and Principe. The key hypothesis is that wars - as pivotal moments that ended the cycle of Empire in Portugal and started the cycle of African independences in the former Portuguese colonies - triggered memorialisation and silencing processes which had their own historicity.
CROME is divided into two strands. The first one, named ‘Colonial Wars, Postcolonial States’, looks at the role played by the states under consideration in mobilising, articulating and recognising the past, but also in actively generating selective representations. ‘Memory as a battlefield’ is the second strand, which will highlight distinct uses of the past and dynamics between social memories and individual memories.
The project intends to demonstrate how wars gave rise to multiple memories and conflicting historical judgements, mostly in Portugal, but also to examine how the specific nature of the (post-)colonial histories of each African country has generated different ways to summon war memories and (anti-)colonial legacies. CROME will, thus, put forward a ground-breaking perspective in terms of colonial-liberation war studies, and will be instrumental in dealing with such traumatic experience, for its comparative approach might help overcoming everlasting constraints still at play today, caused by the historical burden European colonialism left behind.
Summary
Colonial-Liberation Wars generate plural memories, conflicting evocations and persisting amnesias. The project’s main challenge is to produce innovative knowledge about the memories of the wars fought by the Portuguese state and pro-independence African movements between 1961 and 1974/5. The approach chosen is simultaneously diachronic and comparative, inasmuch as it contrasts changes that took place between the end of the conflicts and nowadays, regarding how wars, colonial pasts and anticolonial legacies have been remembered and silenced in Portugal, Angola, Mozambique, Guinea-Bissau, Cape Verde and São Tomé and Principe. The key hypothesis is that wars - as pivotal moments that ended the cycle of Empire in Portugal and started the cycle of African independences in the former Portuguese colonies - triggered memorialisation and silencing processes which had their own historicity.
CROME is divided into two strands. The first one, named ‘Colonial Wars, Postcolonial States’, looks at the role played by the states under consideration in mobilising, articulating and recognising the past, but also in actively generating selective representations. ‘Memory as a battlefield’ is the second strand, which will highlight distinct uses of the past and dynamics between social memories and individual memories.
The project intends to demonstrate how wars gave rise to multiple memories and conflicting historical judgements, mostly in Portugal, but also to examine how the specific nature of the (post-)colonial histories of each African country has generated different ways to summon war memories and (anti-)colonial legacies. CROME will, thus, put forward a ground-breaking perspective in terms of colonial-liberation war studies, and will be instrumental in dealing with such traumatic experience, for its comparative approach might help overcoming everlasting constraints still at play today, caused by the historical burden European colonialism left behind.
Max ERC Funding
1 478 249 €
Duration
Start date: 2017-02-01, End date: 2023-01-31
Project acronym DUNES
Project Sea, Sand and People. An Environmental History of Coastal Dunes
Researcher (PI) Joana FREITAS
Host Institution (HI) Faculdade de letras da Universidade de Lisboa
Country Portugal
Call Details Starting Grant (StG), SH6, ERC-2018-STG
Summary Dunes are now protected environments, being top priority for coastal managers, because of their important role as coastal defences. But, it was not like that in the past.
For centuries dunes were considered unproductive and dangerous. The sand blown by the wind was taken inland, invading fields, silting rivers and destroying villages. In the eighteenth century, a strategy was developed to fight against the dunes: trapping them with trees, with the double purpose of preventing the destruction of arable land and increasing their economic value converting them into forest areas. Different governments, in different countries supported the immobilization of the shifting sands. The strategy, developed in Europe, was taken to other places in the world. These works caused profound changes in vast coastal areas transforming arid landscapes of sandy dunes into green tree forests.
This project aims to explore human-environment relations in coastal areas worldwide, since the eighteenth century until today, through the study of dunes as hybrid landscapes. Based on selected case-studies and comparative approaches, the project will focus on the origins, reasons and means of dunes afforestation; the impacts of the creation of new landscapes to local communities and ecosystems; and the present situation of dunes as coastal defences and rehabilitated environments. The final purpose is to produce an innovative global history of coastal dunes, combining knowledges from both Humanities and Social Sciences and Physical and Life Sciences, which has never been done.
Supported by an interdisciplinary team, this research will result in new developments in the field of the Environmental History studies; provide relevant knowledge considering the need of efficient management solutions to adapt to the expected mean sea level rise; and stimulate environmental citizenship by disseminating the idea that the future of the world coasts depends on today’s actions.
Summary
Dunes are now protected environments, being top priority for coastal managers, because of their important role as coastal defences. But, it was not like that in the past.
For centuries dunes were considered unproductive and dangerous. The sand blown by the wind was taken inland, invading fields, silting rivers and destroying villages. In the eighteenth century, a strategy was developed to fight against the dunes: trapping them with trees, with the double purpose of preventing the destruction of arable land and increasing their economic value converting them into forest areas. Different governments, in different countries supported the immobilization of the shifting sands. The strategy, developed in Europe, was taken to other places in the world. These works caused profound changes in vast coastal areas transforming arid landscapes of sandy dunes into green tree forests.
This project aims to explore human-environment relations in coastal areas worldwide, since the eighteenth century until today, through the study of dunes as hybrid landscapes. Based on selected case-studies and comparative approaches, the project will focus on the origins, reasons and means of dunes afforestation; the impacts of the creation of new landscapes to local communities and ecosystems; and the present situation of dunes as coastal defences and rehabilitated environments. The final purpose is to produce an innovative global history of coastal dunes, combining knowledges from both Humanities and Social Sciences and Physical and Life Sciences, which has never been done.
Supported by an interdisciplinary team, this research will result in new developments in the field of the Environmental History studies; provide relevant knowledge considering the need of efficient management solutions to adapt to the expected mean sea level rise; and stimulate environmental citizenship by disseminating the idea that the future of the world coasts depends on today’s actions.
Max ERC Funding
1 062 330 €
Duration
Start date: 2018-11-01, End date: 2023-10-31
Project acronym EXOEARTHS
Project EXtra-solar planets and stellar astrophysics: towards the detection of Other Earths
Researcher (PI) Nuno Miguel Cardoso Santos
Host Institution (HI) CENTRO DE INVESTIGACAO EM ASTRONOMIA E ASTROFISICA DA UNIVERSIDADE DO PORTO
Country Portugal
Call Details Starting Grant (StG), PE9, ERC-2009-StG
Summary The detection of more than 300 extrasolar planets orbiting other solar-like stars opened the window to a new field of astrophysics. Many projects to search for Earth-like planets are currently under way, using a huge battery of telescopes and instruments. New instrumentation is also being developed towards this goal for use in both ground- and space-based based facilities. Since planets come as an output of the star formation process, the study of the stars hosting planets is of great importance. The stellar-planet connection is strengthened by the fact that most of the exoplanets were discovered using a Doppler radial-velocity technique, where the gravitational influence of the planet on the star and not the planet itself is actually measured. This project aims at doing frontier research to explore i) in unique detail the stellar limitations of the radial-velocity technique, as well as ways of reducing them, having in mind the detection of Earth-like planets and ii) to develop and apply software packages aiming at the study of the properties of the planet-host stars, having in mind the full characterization of the newfound planets, as well as understanding planet formation processes. These goals will improve our capacity to detect, study, and characterize new very low mass extra-solar planets. EXOEarths further fits into the fact that I am currently Co-PI of the project for a new high-resolution ultra-stable spectrograph for the VLT. The results of this project are crucial to fully exploit this new instrument. They will be also of extreme importance to current state-of-the-art planet-search projects aiming at the discovery of other Earths, in particular those making use of the radial-velocity method.
Summary
The detection of more than 300 extrasolar planets orbiting other solar-like stars opened the window to a new field of astrophysics. Many projects to search for Earth-like planets are currently under way, using a huge battery of telescopes and instruments. New instrumentation is also being developed towards this goal for use in both ground- and space-based based facilities. Since planets come as an output of the star formation process, the study of the stars hosting planets is of great importance. The stellar-planet connection is strengthened by the fact that most of the exoplanets were discovered using a Doppler radial-velocity technique, where the gravitational influence of the planet on the star and not the planet itself is actually measured. This project aims at doing frontier research to explore i) in unique detail the stellar limitations of the radial-velocity technique, as well as ways of reducing them, having in mind the detection of Earth-like planets and ii) to develop and apply software packages aiming at the study of the properties of the planet-host stars, having in mind the full characterization of the newfound planets, as well as understanding planet formation processes. These goals will improve our capacity to detect, study, and characterize new very low mass extra-solar planets. EXOEarths further fits into the fact that I am currently Co-PI of the project for a new high-resolution ultra-stable spectrograph for the VLT. The results of this project are crucial to fully exploit this new instrument. They will be also of extreme importance to current state-of-the-art planet-search projects aiming at the discovery of other Earths, in particular those making use of the radial-velocity method.
Max ERC Funding
928 090 €
Duration
Start date: 2009-10-01, End date: 2014-12-31
Project acronym FARE
Project FAKE NEWS AND REAL PEOPLE – USING BIG DATA TO UNDERSTAND HUMAN BEHAVIOUR
Researcher (PI) Maria Joana GONcALVES-Sa
Host Institution (HI) LABORATORIO DE INSTRUMENTACAO E FISICA EXPERIMENTAL DE PARTICULAS LIP
Country Portugal
Call Details Starting Grant (StG), SH3, ERC-2019-STG
Summary Recent events, from the anti-vaccination movement, to Brexit and even to mob killings, have raised serious concerns about the influence of the so-called fake news (FN). False information is not new in human history, but the recent surge in online activity, coupled with poor digital literacy, consumer profiling, and large profits from ad revenues, created a perfect storm for the FN epidemic, with still unimaginable consequences.
This challenge is interdisciplinary and requires academic research to guide current calls for action issued by academics, governmental and non-governmental agencies, and the social network platforms themselves. FARE will enrich current efforts, which mostly confront FN spreading from an applied perspective, by offering a theoretical framework that allows to make testable predictions. FARE argues that sharing of FN is a deviation from pure rationality and brings together 1) state of the art knowledge in behavioural psychology, to assess the role that cognitive biases play in susceptibility to FN, and 2) current models in network science and epidemiology, to test whether FN spread more like simple or complex contagions. Finally, fully recognizing that these novel big-data approaches carry great risks, FARE will develop a new strategy, mostly based on distributed computing, and guidelines to the ethical handling of human-related big-data.
Together, FARE will offer a comprehensive model to ask questions such as: 1) What role(s) cognitive biases play in FN spreading? 2) How does network architecture affect FNs spread? 3) How do biases and position on networks build on each other to impact propagation? 4) What monitoring and mitigation interventions are likely to be more efficient?
Moreover, the study of FN from such a conceptual perspective has the potential to profoundly increase our knowledge on human behaviour and information spread, beyond specific problems, with implications for communication (science, political), economics, and psychology.
Summary
Recent events, from the anti-vaccination movement, to Brexit and even to mob killings, have raised serious concerns about the influence of the so-called fake news (FN). False information is not new in human history, but the recent surge in online activity, coupled with poor digital literacy, consumer profiling, and large profits from ad revenues, created a perfect storm for the FN epidemic, with still unimaginable consequences.
This challenge is interdisciplinary and requires academic research to guide current calls for action issued by academics, governmental and non-governmental agencies, and the social network platforms themselves. FARE will enrich current efforts, which mostly confront FN spreading from an applied perspective, by offering a theoretical framework that allows to make testable predictions. FARE argues that sharing of FN is a deviation from pure rationality and brings together 1) state of the art knowledge in behavioural psychology, to assess the role that cognitive biases play in susceptibility to FN, and 2) current models in network science and epidemiology, to test whether FN spread more like simple or complex contagions. Finally, fully recognizing that these novel big-data approaches carry great risks, FARE will develop a new strategy, mostly based on distributed computing, and guidelines to the ethical handling of human-related big-data.
Together, FARE will offer a comprehensive model to ask questions such as: 1) What role(s) cognitive biases play in FN spreading? 2) How does network architecture affect FNs spread? 3) How do biases and position on networks build on each other to impact propagation? 4) What monitoring and mitigation interventions are likely to be more efficient?
Moreover, the study of FN from such a conceptual perspective has the potential to profoundly increase our knowledge on human behaviour and information spread, beyond specific problems, with implications for communication (science, political), economics, and psychology.
Max ERC Funding
1 499 844 €
Duration
Start date: 2020-10-01, End date: 2025-09-30
Project acronym FattyCyanos
Project Fatty acid incorporation and modification in cyanobacterial natural products
Researcher (PI) Pedro LEaO
Host Institution (HI) CENTRO INTERDISCIPLINAR DE INVESTIGACAO MARINHA E AMBIENTAL
Country Portugal
Call Details Starting Grant (StG), PE5, ERC-2017-STG
Summary Known, but mostly novel natural products (NPs) are in high demand – these are used in drugs, cosmetics and agrochemicals and serve also as research tools to probe biological systems. NP structures inspire chemists to develop new syntheses, and NP biosynthetic enzymes add to the metabolic engineer’s toolbox. The advent of next generation DNA-sequencing has revealed a vastly rich pool of NP biosynthetic gene clusters (BGCs) among bacterial genomes, most of which with no corresponding NP. Hence, opportunities abound for the discovery of new chemistry and enzymology that has the potential to push the boundaries of chemical space and enzymatic reactivity. Still, we cannot reliably predict chemistry from BGCs with unusual organization or encoding unknown functionalities, and, for molecules of unorthodox architecture, it is difficult to anticipate how their BGCs are organized. It is the valuable, truly novel chemistry and biochemistry that lies on these unexplored connections, that we aim to reveal with this proposal. To achieve it, we will work with a chemically-talented group of organisms – cyanobacteria, and with a specific structural class – fatty acids (FAs) – that is metabolized in a quite peculiar fashion by these organisms, paving the way for NP and enzyme discovery. On one hand, we will exploit the unique FA metabolism of cyanobacteria to develop a feeding strategy that will quickly reveal unprecedented FA-incorporating NPs. On the other, we will scrutinize the intriguing biosynthesis of three unique classes of metabolites that we have isolated recently and that incorporate and modify FA-moieties. We will find the BGCs for these compounds and dissect the functionality involved in such puzzling modifications to uncover important underlying enzymatic chemistry. This proposal is a blend of discovery- and hypothesis-driven research at the NP chemistry/biosynthesis interface that draws on the experience of the PI’s work on different aspects of cyanobacterial NPs.
Summary
Known, but mostly novel natural products (NPs) are in high demand – these are used in drugs, cosmetics and agrochemicals and serve also as research tools to probe biological systems. NP structures inspire chemists to develop new syntheses, and NP biosynthetic enzymes add to the metabolic engineer’s toolbox. The advent of next generation DNA-sequencing has revealed a vastly rich pool of NP biosynthetic gene clusters (BGCs) among bacterial genomes, most of which with no corresponding NP. Hence, opportunities abound for the discovery of new chemistry and enzymology that has the potential to push the boundaries of chemical space and enzymatic reactivity. Still, we cannot reliably predict chemistry from BGCs with unusual organization or encoding unknown functionalities, and, for molecules of unorthodox architecture, it is difficult to anticipate how their BGCs are organized. It is the valuable, truly novel chemistry and biochemistry that lies on these unexplored connections, that we aim to reveal with this proposal. To achieve it, we will work with a chemically-talented group of organisms – cyanobacteria, and with a specific structural class – fatty acids (FAs) – that is metabolized in a quite peculiar fashion by these organisms, paving the way for NP and enzyme discovery. On one hand, we will exploit the unique FA metabolism of cyanobacteria to develop a feeding strategy that will quickly reveal unprecedented FA-incorporating NPs. On the other, we will scrutinize the intriguing biosynthesis of three unique classes of metabolites that we have isolated recently and that incorporate and modify FA-moieties. We will find the BGCs for these compounds and dissect the functionality involved in such puzzling modifications to uncover important underlying enzymatic chemistry. This proposal is a blend of discovery- and hypothesis-driven research at the NP chemistry/biosynthesis interface that draws on the experience of the PI’s work on different aspects of cyanobacterial NPs.
Max ERC Funding
1 462 938 €
Duration
Start date: 2018-01-01, End date: 2022-12-31
Project acronym INTIMATE
Project "Citizenship, Care and Choice: The Micropolitics of Intimacy in Southern Europe"
Researcher (PI) Ana Cristina Alvarez Caiano Da Silva Santos
Host Institution (HI) CENTRO DE ESTUDOS SOCIAIS
Country Portugal
Call Details Starting Grant (StG), SH2, ERC-2013-StG
Summary "Changes in personal life in recent decades illustrate significant socio-cultural transformations. However, the focus of mainstream sociological literature has been the heterosexual, monogamic and reproductive couple, with little research exploring non-conventional intimacy in Southern Europe. INTIMATE’s main aim is to contribute to legal, policy and cultural innovation through the findings of a comparative, empirically-grounded, research project designed to rethink citizenship, care and choice from the point of view of 'non-standard intimacies' (Berlant and Warner, 2000) in 3 contrasting Southern European countries: Italy, Portugal and Spain.
Guided by the fundamental sociological question of how change takes place and, concomitantly, how law and social policy adjust to and/or shape the practices and expectations of individuals concerning personal life, this research will address intimacy from the perspective of those on the margins of social, legal and policy concerns in Southern Europe – lesbians, gay men, bisexuals and transgendered people.
INTIMATE is based on 3 strands – Strand 1: the micropolitics of partnering; Strand 2: the micropolitics of parenting; and Strand 3: the micropolitics of friendship. The notion of micropolitics enables a double focus on everyday practices and expectations (biographic dimension) within the wider contextual framework of law and social policy (socio-legal dimension).
This qualitative research involves conducting 6 cross-national qualitative studies across the strands of partnering, parenting and friendship in each of the chosen countries. Topics covered are lesbian coupledom, polyamorous relationships, assisted conception and surrogacy, naming a child, transgender and care, and living with friends in adult life.
Expected results include a range of both international and national publications targeting academia and beyond, thematic conferences and participatory workshops, policy briefs, media briefs and an interactive website."
Summary
"Changes in personal life in recent decades illustrate significant socio-cultural transformations. However, the focus of mainstream sociological literature has been the heterosexual, monogamic and reproductive couple, with little research exploring non-conventional intimacy in Southern Europe. INTIMATE’s main aim is to contribute to legal, policy and cultural innovation through the findings of a comparative, empirically-grounded, research project designed to rethink citizenship, care and choice from the point of view of 'non-standard intimacies' (Berlant and Warner, 2000) in 3 contrasting Southern European countries: Italy, Portugal and Spain.
Guided by the fundamental sociological question of how change takes place and, concomitantly, how law and social policy adjust to and/or shape the practices and expectations of individuals concerning personal life, this research will address intimacy from the perspective of those on the margins of social, legal and policy concerns in Southern Europe – lesbians, gay men, bisexuals and transgendered people.
INTIMATE is based on 3 strands – Strand 1: the micropolitics of partnering; Strand 2: the micropolitics of parenting; and Strand 3: the micropolitics of friendship. The notion of micropolitics enables a double focus on everyday practices and expectations (biographic dimension) within the wider contextual framework of law and social policy (socio-legal dimension).
This qualitative research involves conducting 6 cross-national qualitative studies across the strands of partnering, parenting and friendship in each of the chosen countries. Topics covered are lesbian coupledom, polyamorous relationships, assisted conception and surrogacy, naming a child, transgender and care, and living with friends in adult life.
Expected results include a range of both international and national publications targeting academia and beyond, thematic conferences and participatory workshops, policy briefs, media briefs and an interactive website."
Max ERC Funding
1 462 537 €
Duration
Start date: 2014-03-01, End date: 2019-02-28