Project acronym ESSOG
Project Extracting science from surveys of our Galaxy
Researcher (PI) James Jeffrey Binney
Host Institution (HI) THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Country United Kingdom
Call Details Advanced Grant (AdG), PE9, ERC-2012-ADG_20120216
Summary "The goal is to put in place the infrastructure required to extract the promised science for large surveys of our Galaxy that are underway and will culminate in ESA's Cornerstone Mission Gaia. Dynamical models are fundamental to this process because surveys are heavily biased by the Sun's location in the Galaxy. Novel dynamical models will be built and novel methods of fitting them to the data developed. With their help we will be able to constrain the distribution of dark matter in the Galaxy. By modelling the chemical and dynamical evolution of the Galaxy we expect to be able to infer much information about how the Galaxy was assembled, and thus test the prevailing cosmological paradigm. During the grant period we will be applying our tools to ground-based surveys, but the first version of the Gaia Catalogue will become available at the end of the grant period, and our goal is to have everything ready and tested for its prompt exploitation."
Summary
"The goal is to put in place the infrastructure required to extract the promised science for large surveys of our Galaxy that are underway and will culminate in ESA's Cornerstone Mission Gaia. Dynamical models are fundamental to this process because surveys are heavily biased by the Sun's location in the Galaxy. Novel dynamical models will be built and novel methods of fitting them to the data developed. With their help we will be able to constrain the distribution of dark matter in the Galaxy. By modelling the chemical and dynamical evolution of the Galaxy we expect to be able to infer much information about how the Galaxy was assembled, and thus test the prevailing cosmological paradigm. During the grant period we will be applying our tools to ground-based surveys, but the first version of the Gaia Catalogue will become available at the end of the grant period, and our goal is to have everything ready and tested for its prompt exploitation."
Max ERC Funding
1 954 460 €
Duration
Start date: 2013-04-01, End date: 2018-03-31
Project acronym GENEWELL
Project Genetics and epigenetics of animal welfare
Researcher (PI) Per Ole Stokmann Jensen
Host Institution (HI) LINKOPINGS UNIVERSITET
Country Sweden
Call Details Advanced Grant (AdG), LS9, ERC-2012-ADG_20120314
Summary Animal welfare is a topic of highest societal and scientific priority. Here, I propose to use genomic and epigenetic tools to provide a new perspective on the biology of animal welfare. This will reveal mechanisms involved in modulating stress responses. Groundbreaking aspects include new insights into how environmental conditions shape the orchestration of the genome by means of epigenetic mechanisms, and how this in turn modulates coping patterns of animals. The flexible epigenome comprises the interface between the environment and the genome. It is involved in both short- and long-term, including transgenerational, adaptations of animals. Hence, populations may adapt to environmental conditions over generations, using epigenetic mechanisms. The project will primarily be based on chickens, but will also be extended to a novel species, the dog. We will generate congenic chicken strains, where interesting alleles and epialleles will be fixed against a common background of either RJF or domestic genotypes. In these, we will apply a broad phenotyping strategy, to characterize the effects on different welfare relevant behaviors. Furthermore, we will characterize how environmental stress affects the epigenome of birds, and tissue samples from more than 500 birds from an intercross between RJF and White Leghorn layers will be used to perform an extensive meth-QTL-analysis. This will reveal environmental and genetic mechanisms affecting gene-specific methylation. The dog is another highly interesting species in the context of behavior genetics, because of its high inter-breed variation in behavior, and its compact and sequenced genome. We will set up a large-scale F2-intercross experiment and phenotype about 400 dogs in standardized behavioral tests. All individuals will be genotyped on about 1000 genetic markers, and this will be used for performing an extensive QTL-analysis in order to find new loci and alleles associated with personalities and coping patterns.
Summary
Animal welfare is a topic of highest societal and scientific priority. Here, I propose to use genomic and epigenetic tools to provide a new perspective on the biology of animal welfare. This will reveal mechanisms involved in modulating stress responses. Groundbreaking aspects include new insights into how environmental conditions shape the orchestration of the genome by means of epigenetic mechanisms, and how this in turn modulates coping patterns of animals. The flexible epigenome comprises the interface between the environment and the genome. It is involved in both short- and long-term, including transgenerational, adaptations of animals. Hence, populations may adapt to environmental conditions over generations, using epigenetic mechanisms. The project will primarily be based on chickens, but will also be extended to a novel species, the dog. We will generate congenic chicken strains, where interesting alleles and epialleles will be fixed against a common background of either RJF or domestic genotypes. In these, we will apply a broad phenotyping strategy, to characterize the effects on different welfare relevant behaviors. Furthermore, we will characterize how environmental stress affects the epigenome of birds, and tissue samples from more than 500 birds from an intercross between RJF and White Leghorn layers will be used to perform an extensive meth-QTL-analysis. This will reveal environmental and genetic mechanisms affecting gene-specific methylation. The dog is another highly interesting species in the context of behavior genetics, because of its high inter-breed variation in behavior, and its compact and sequenced genome. We will set up a large-scale F2-intercross experiment and phenotype about 400 dogs in standardized behavioral tests. All individuals will be genotyped on about 1000 genetic markers, and this will be used for performing an extensive QTL-analysis in order to find new loci and alleles associated with personalities and coping patterns.
Max ERC Funding
2 499 828 €
Duration
Start date: 2013-03-01, End date: 2018-02-28
Project acronym M4D
Project Metal Microstructures in Four Dimensions
Researcher (PI) Dorte JUUL JENSEN
Host Institution (HI) DANMARKS TEKNISKE UNIVERSITET
Country Denmark
Call Details Advanced Grant (AdG), PE8, ERC-2017-ADG
Summary The goals are:
1) to develop a universal laboratory-based 4D X-ray microscope with potentials in the broad field of materials science and beyond;
2) to advance metal research by quantifying local microstructural variations using the new 4D tool and by including the effects hereof in the understanding and modelling of industrially relevant metals.
Today, high resolution 4D (x,y,z,time) crystallographic characterization of materials is possible only at large international facilities. This is a serious limitation preventing the common use. The new technique will allow such 4D characterization to be carried out at home laboratories, thereby wide spreading this powerful tool.
Whereas current metal research mainly focuses on average properties, local microstructural variations are present in all metals on several length scales, and are often of critical importance for the properties and performance of the metal. In this project, the new technique will be the cornerstone in studies of such variations in three types of metallic materials: 3D printed, multilayered and micrometre-scale metals. Effects of local variations on the subsequent microstructural evolution will be followed during deformation and annealing, i.e. during processes typical for manufacturing, and occurring during in-service operation.
Current models largely ignore the presence of local microstructural variations and lack predictive power. Based on the new experimental data, three models operating on different length scales will be improved and combined, namely crystal plasticity finite element, phase field and molecular dynamics models. The main novelty here relates to the full 4D validation of the models, which has not been possible hitherto because of lack of sufficient experimental data.
The resulting fundamental understanding of the inherent microstructural variations and the new models are foreseen to be an integral part of the future design of metallic materials for high performance applications.
Summary
The goals are:
1) to develop a universal laboratory-based 4D X-ray microscope with potentials in the broad field of materials science and beyond;
2) to advance metal research by quantifying local microstructural variations using the new 4D tool and by including the effects hereof in the understanding and modelling of industrially relevant metals.
Today, high resolution 4D (x,y,z,time) crystallographic characterization of materials is possible only at large international facilities. This is a serious limitation preventing the common use. The new technique will allow such 4D characterization to be carried out at home laboratories, thereby wide spreading this powerful tool.
Whereas current metal research mainly focuses on average properties, local microstructural variations are present in all metals on several length scales, and are often of critical importance for the properties and performance of the metal. In this project, the new technique will be the cornerstone in studies of such variations in three types of metallic materials: 3D printed, multilayered and micrometre-scale metals. Effects of local variations on the subsequent microstructural evolution will be followed during deformation and annealing, i.e. during processes typical for manufacturing, and occurring during in-service operation.
Current models largely ignore the presence of local microstructural variations and lack predictive power. Based on the new experimental data, three models operating on different length scales will be improved and combined, namely crystal plasticity finite element, phase field and molecular dynamics models. The main novelty here relates to the full 4D validation of the models, which has not been possible hitherto because of lack of sufficient experimental data.
The resulting fundamental understanding of the inherent microstructural variations and the new models are foreseen to be an integral part of the future design of metallic materials for high performance applications.
Max ERC Funding
2 496 519 €
Duration
Start date: 2018-10-01, End date: 2023-09-30
Project acronym WATERUNDERTHEICE
Project Where is the water under the Greenland ice sheet?
Researcher (PI) Dorthe Dahl-Jensen
Host Institution (HI) KOBENHAVNS UNIVERSITET
Country Denmark
Call Details Advanced Grant (AdG), PE10, ERC-2009-AdG
Summary Recent analysis of radar-depth sounder data has shown that many areas of the Greenland ice sheet have melt water under the base. The extent of the wet base and distribution of melt water are poorly known. Also lakes under the ice have not been discovered in contrast with those in Antarctica. The effect of the water beneath the ice, however, is well documented: it lubricates the bed and removes the friction between the basal ice and underlying bedrock. The ice with a wet bed flows faster, reacts rapidly to changes in climate and the basal-melt water contributes to the fresh-water supply to the ocean from the Greenland ice sheet. The primary objectives of the project are to map melt water extent of the Greenland ice sheet and its impact by tracing internal layers and analyzing bedrock returns from airborne radio-echo sounding data, and use mapping results in conjunction with ice-sheet and hydrostatic models for the movement of the basal water to predict the ice-sheet s response to climate change. The information derived from deep ice-cores that reach the bed will be used to constrain models. We will also study the basal material (dust, DNA and microbiological material) and bedrock properties from the deep-ice core sites. This will add a further dimension to the study and provide opportunities to look for life under the ice and constrain the age of the Greenland ice sheet. The proposed research is a high risk project because of the difficulty in accessing basal conditions under 3-km of ice with a potential for high payoff science. The team will consist of scientists and engineers with expertise in the palaeoclimate, radar sounding and signal processing, and ice-sheet models.
Summary
Recent analysis of radar-depth sounder data has shown that many areas of the Greenland ice sheet have melt water under the base. The extent of the wet base and distribution of melt water are poorly known. Also lakes under the ice have not been discovered in contrast with those in Antarctica. The effect of the water beneath the ice, however, is well documented: it lubricates the bed and removes the friction between the basal ice and underlying bedrock. The ice with a wet bed flows faster, reacts rapidly to changes in climate and the basal-melt water contributes to the fresh-water supply to the ocean from the Greenland ice sheet. The primary objectives of the project are to map melt water extent of the Greenland ice sheet and its impact by tracing internal layers and analyzing bedrock returns from airborne radio-echo sounding data, and use mapping results in conjunction with ice-sheet and hydrostatic models for the movement of the basal water to predict the ice-sheet s response to climate change. The information derived from deep ice-cores that reach the bed will be used to constrain models. We will also study the basal material (dust, DNA and microbiological material) and bedrock properties from the deep-ice core sites. This will add a further dimension to the study and provide opportunities to look for life under the ice and constrain the age of the Greenland ice sheet. The proposed research is a high risk project because of the difficulty in accessing basal conditions under 3-km of ice with a potential for high payoff science. The team will consist of scientists and engineers with expertise in the palaeoclimate, radar sounding and signal processing, and ice-sheet models.
Max ERC Funding
2 499 999 €
Duration
Start date: 2010-01-01, End date: 2015-12-31
