Project acronym 2SEXES_1GENOME
Project Sex-specific genetic effects on fitness and human disease
Researcher (PI) Edward Hugh Morrow
Host Institution (HI) THE UNIVERSITY OF SUSSEX
Call Details Starting Grant (StG), LS8, ERC-2011-StG_20101109
Summary Darwin’s theory of natural selection rests on the principle that fitness variation in natural populations has a heritable component, on which selection acts, thereby leading to evolutionary change. A fundamental and so far unresolved question for the field of evolutionary biology is to identify the genetic loci responsible for this fitness variation, thereby coming closer to an understanding of how variation is maintained in the face of continual selection. One important complicating factor in the search for fitness related genes however is the existence of separate sexes – theoretical expectations and empirical data both suggest that sexually antagonistic genes are common. The phrase “two sexes, one genome” nicely sums up the problem; selection may favour alleles in one sex, even if they have detrimental effects on the fitness of the opposite sex, since it is their net effect across both sexes that determine the likelihood that alleles persist in a population. This theoretical framework raises an interesting, and so far entirely unexplored issue: that in one sex the functional performance of some alleles is predicted to be compromised and this effect may account for some common human diseases and conditions which show genotype-sex interactions. I propose to explore the genetic basis of sex-specific fitness in a model organism in both laboratory and natural conditions and to test whether those genes identified as having sexually antagonistic effects can help explain the incidence of human diseases that display sexual dimorphism in prevalence, age of onset or severity. This multidisciplinary project directly addresses some fundamental unresolved questions in evolutionary biology: the genetic basis and maintenance of fitness variation; the evolution of sexual dimorphism; and aims to provide novel insights into the genetic basis of some common human diseases.
Summary
Darwin’s theory of natural selection rests on the principle that fitness variation in natural populations has a heritable component, on which selection acts, thereby leading to evolutionary change. A fundamental and so far unresolved question for the field of evolutionary biology is to identify the genetic loci responsible for this fitness variation, thereby coming closer to an understanding of how variation is maintained in the face of continual selection. One important complicating factor in the search for fitness related genes however is the existence of separate sexes – theoretical expectations and empirical data both suggest that sexually antagonistic genes are common. The phrase “two sexes, one genome” nicely sums up the problem; selection may favour alleles in one sex, even if they have detrimental effects on the fitness of the opposite sex, since it is their net effect across both sexes that determine the likelihood that alleles persist in a population. This theoretical framework raises an interesting, and so far entirely unexplored issue: that in one sex the functional performance of some alleles is predicted to be compromised and this effect may account for some common human diseases and conditions which show genotype-sex interactions. I propose to explore the genetic basis of sex-specific fitness in a model organism in both laboratory and natural conditions and to test whether those genes identified as having sexually antagonistic effects can help explain the incidence of human diseases that display sexual dimorphism in prevalence, age of onset or severity. This multidisciplinary project directly addresses some fundamental unresolved questions in evolutionary biology: the genetic basis and maintenance of fitness variation; the evolution of sexual dimorphism; and aims to provide novel insights into the genetic basis of some common human diseases.
Max ERC Funding
1 500 000 €
Duration
Start date: 2012-01-01, End date: 2016-12-31
Project acronym ArtifiCell
Project Synthetic Cell Biology: Designing organelle transport mechanisms
Researcher (PI) James Edward Rothman
Host Institution (HI) UNIVERSITY COLLEGE LONDON
Call Details Advanced Grant (AdG), LS3, ERC-2014-ADG
Summary Imagine being able to design into living cells and organisms de novo vesicle transport mechanisms that do not naturally exist? At one level this is a wild-eyed notion of synthetic biology.
But we contend that this vision can be approached even today, focusing first on the process of exocytosis, a fundamental process that impacts almost every area of physiology. Enough has now been learned about the natural core machinery (as recognized by the award of the 2013 Nobel Prize in Physiology or Medicine to the PI and others) to take highly innovative physics/engineering- and DNA-based approaches to design synthetic versions of the secretory apparatus that could someday open new avenues in genetic medicine.
The central idea is to introduce DNA-based functional equivalents of the core protein machinery that naturally form (coats), target (tethers), and fuse (SNAREs) vesicles. We have already taken first steps by using DNA origami-based templates to produce synthetic phospholipid vesicles and complementary DNA-based tethers to specifically capture these DNA-templated vesicles on targeted bilayers. Others have linked DNA oligonucleotides to trigger vesicle fusion.
The next and much more challenging step is to introduce such processes into living cells. We hope to break this barrier, and in the process start a new field of research into “synthetic exocytosis”, by introducing Peptide-Nucleic Acids (PNAs) of tethers and SNAREs to re-direct naturally-produced secretory vesicles to artificially-programmed targets and provide artificially-programmed regulation. PNAs are chosen mainly because they lack the negatively charged phosphate backbones of DNA, and therefore are more readily delivered into the cell across the plasma membrane. Future steps, would include producing the transport vesicles synthetically within the cell by externally supplied origami-based PNA or similar cages, and - much more speculatively - ultimately using encoded DNA and RNAs to provide these functions.
Summary
Imagine being able to design into living cells and organisms de novo vesicle transport mechanisms that do not naturally exist? At one level this is a wild-eyed notion of synthetic biology.
But we contend that this vision can be approached even today, focusing first on the process of exocytosis, a fundamental process that impacts almost every area of physiology. Enough has now been learned about the natural core machinery (as recognized by the award of the 2013 Nobel Prize in Physiology or Medicine to the PI and others) to take highly innovative physics/engineering- and DNA-based approaches to design synthetic versions of the secretory apparatus that could someday open new avenues in genetic medicine.
The central idea is to introduce DNA-based functional equivalents of the core protein machinery that naturally form (coats), target (tethers), and fuse (SNAREs) vesicles. We have already taken first steps by using DNA origami-based templates to produce synthetic phospholipid vesicles and complementary DNA-based tethers to specifically capture these DNA-templated vesicles on targeted bilayers. Others have linked DNA oligonucleotides to trigger vesicle fusion.
The next and much more challenging step is to introduce such processes into living cells. We hope to break this barrier, and in the process start a new field of research into “synthetic exocytosis”, by introducing Peptide-Nucleic Acids (PNAs) of tethers and SNAREs to re-direct naturally-produced secretory vesicles to artificially-programmed targets and provide artificially-programmed regulation. PNAs are chosen mainly because they lack the negatively charged phosphate backbones of DNA, and therefore are more readily delivered into the cell across the plasma membrane. Future steps, would include producing the transport vesicles synthetically within the cell by externally supplied origami-based PNA or similar cages, and - much more speculatively - ultimately using encoded DNA and RNAs to provide these functions.
Max ERC Funding
3 000 000 €
Duration
Start date: 2015-09-01, End date: 2021-08-31
Project acronym BG-BB-AS
Project Birational Geometry, B-branes and Artin Stacks
Researcher (PI) Edward Paul Segal
Host Institution (HI) UNIVERSITY COLLEGE LONDON
Call Details Consolidator Grant (CoG), PE1, ERC-2016-COG
Summary Derived categories of coherent sheaves on a variety are a fundamental tool in algebraic geometry. They also arise in String Theory, as the category of B-branes in a quantum field theory whose target space is the variety. This connection to physics has been extraordinarily fruitful, providing deep insights and conjectures.
An Artin stack is a sophisticated generalization of a variety, they encode the idea of equivariant geometry. A simple example is a vector space carrying a linear action of a Lie group. In String Theory this data defines a Gauged Linear Sigma Model, which is a basic tool in the subject. A GLSM should also give rise to a category of B-branes, but surprisingly it is not yet understood what this should be. An overarching goal of this project is to develop an understanding of this category (more accurately, system of categories), and to extend this understanding to more general Artin stacks.
The basic importance of this question is that in certain limits a GLSM reduces to a sigma model, whose target is a quotient of the vector space by the group. This quotient must be taken using Geometric Invariant Theory. Thus this project is intimately connected with the question of how derived categories change under variation-of-GIT, and birational maps in general.
For GLSMs with abelian groups this approach has already produced spectacular results, in the non-abelian case we understand only a few remarkable examples. We will develop these examples into a wide-ranging general theory.
Our key objectives are to:
- Provide powerful new tools for controlling the behaviour of derived categories under birational maps.
- Understand the category of B-branes on a large class of Artin stacks.
- Prove and apply a striking new duality between GLSMs.
- Construct completely new symmetries of derived categories.
Summary
Derived categories of coherent sheaves on a variety are a fundamental tool in algebraic geometry. They also arise in String Theory, as the category of B-branes in a quantum field theory whose target space is the variety. This connection to physics has been extraordinarily fruitful, providing deep insights and conjectures.
An Artin stack is a sophisticated generalization of a variety, they encode the idea of equivariant geometry. A simple example is a vector space carrying a linear action of a Lie group. In String Theory this data defines a Gauged Linear Sigma Model, which is a basic tool in the subject. A GLSM should also give rise to a category of B-branes, but surprisingly it is not yet understood what this should be. An overarching goal of this project is to develop an understanding of this category (more accurately, system of categories), and to extend this understanding to more general Artin stacks.
The basic importance of this question is that in certain limits a GLSM reduces to a sigma model, whose target is a quotient of the vector space by the group. This quotient must be taken using Geometric Invariant Theory. Thus this project is intimately connected with the question of how derived categories change under variation-of-GIT, and birational maps in general.
For GLSMs with abelian groups this approach has already produced spectacular results, in the non-abelian case we understand only a few remarkable examples. We will develop these examples into a wide-ranging general theory.
Our key objectives are to:
- Provide powerful new tools for controlling the behaviour of derived categories under birational maps.
- Understand the category of B-branes on a large class of Artin stacks.
- Prove and apply a striking new duality between GLSMs.
- Construct completely new symmetries of derived categories.
Max ERC Funding
1 358 925 €
Duration
Start date: 2017-09-01, End date: 2022-08-31
Project acronym BOTFIND
Project BOTFIND: Finding Bots, Detect Harassing Automation, and Restoring Trust in Social Media Civic Engagement
Researcher (PI) Philip Edward HOWARD
Host Institution (HI) THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Call Details Proof of Concept (PoC), ERC-2017-PoC
Summary Social media platforms have become tools for manipulating public opinion during elections. In particular, “bots” are algorithms that automate rapid, widespread interactions with citizens, often with deleterious effects on public knowledge of science, social inequality, and public policy options. Through the ERC COMPROP Consolidator award, researchers have demonstrated that even simple bots (i) effectively keep negative messages and fake news in circulation longer (ii) target journalists and civil society groups and (iii) operate with little oversight from social media firms. Such algorithms have negative consequences both for public trust in technology innovation and for the quality of public deliberation in Europe’s democracies. ERC researchers have been able to identify highly automated, politically-manipulative social media accounts post hoc. This project will allow researchers to take what we have learned and produce an online tool that allows people to evaluate suspicious social media accounts. Most social media platforms are slow to address troll and bot activity, so this innovative tool will put ERC research into public service in Europe—and around the world.
Summary
Social media platforms have become tools for manipulating public opinion during elections. In particular, “bots” are algorithms that automate rapid, widespread interactions with citizens, often with deleterious effects on public knowledge of science, social inequality, and public policy options. Through the ERC COMPROP Consolidator award, researchers have demonstrated that even simple bots (i) effectively keep negative messages and fake news in circulation longer (ii) target journalists and civil society groups and (iii) operate with little oversight from social media firms. Such algorithms have negative consequences both for public trust in technology innovation and for the quality of public deliberation in Europe’s democracies. ERC researchers have been able to identify highly automated, politically-manipulative social media accounts post hoc. This project will allow researchers to take what we have learned and produce an online tool that allows people to evaluate suspicious social media accounts. Most social media platforms are slow to address troll and bot activity, so this innovative tool will put ERC research into public service in Europe—and around the world.
Max ERC Funding
149 921 €
Duration
Start date: 2017-08-01, End date: 2019-01-31
Project acronym CARDYADS
Project Controlling Cardiomyocyte Dyadic Structure
Researcher (PI) William Edward Louch
Host Institution (HI) UNIVERSITETET I OSLO
Call Details Consolidator Grant (CoG), LS4, ERC-2014-CoG
Summary Contraction and relaxation of cardiac myocytes, and thus the whole heart, are critically dependent on dyads. These functional junctions between t-tubules, which are invaginations of the surface membrane, and the sarcoplasmic reticulum allow efficient control of calcium release into the cytosol, and also its removal. Dyads are formed gradually during development and break down during disease. However, the precise nature of dyadic structure is unclear, even in healthy adult cardiac myocytes, as are the triggers and consequences of altering dyadic integrity. In this proposal, my group will investigate the precise 3-dimensional arrangement of dyads and their proteins during development, adulthood, and heart failure by employing CLEM imaging (PALM and EM tomography). This will be accomplished by developing transgenic mice with fluorescent labels on four dyadic proteins (L-type calcium channel, ryanodine receptor, sodium-calcium exchanger, SERCA), and by imaging tissue from explanted normal and failing human hearts. The signals responsible for controlling dyadic formation, maintenance, and disruption will be determined by performing high-throughput sequencing to identify novel genes involved with these processes in several established model systems. Particular focus will be given to investigating left ventricular wall stress and stretch-dependent gene regulation as controllers of dyadic integrity. Candidate genes will be manipulated in cell models and transgenic animals to promote dyadic formation and maintenance, and reverse dyadic disruption in heart failure. The consequences of dyadic structure for function will be tested experimentally and with mathematical modeling to examine effects on cardiac myocyte calcium homeostasis and whole-heart function. The results of this project are anticipated to yield unprecedented insight into dyadic structure, regulation, and function, and to identify novel therapeutic targets for heart disease patients.
Summary
Contraction and relaxation of cardiac myocytes, and thus the whole heart, are critically dependent on dyads. These functional junctions between t-tubules, which are invaginations of the surface membrane, and the sarcoplasmic reticulum allow efficient control of calcium release into the cytosol, and also its removal. Dyads are formed gradually during development and break down during disease. However, the precise nature of dyadic structure is unclear, even in healthy adult cardiac myocytes, as are the triggers and consequences of altering dyadic integrity. In this proposal, my group will investigate the precise 3-dimensional arrangement of dyads and their proteins during development, adulthood, and heart failure by employing CLEM imaging (PALM and EM tomography). This will be accomplished by developing transgenic mice with fluorescent labels on four dyadic proteins (L-type calcium channel, ryanodine receptor, sodium-calcium exchanger, SERCA), and by imaging tissue from explanted normal and failing human hearts. The signals responsible for controlling dyadic formation, maintenance, and disruption will be determined by performing high-throughput sequencing to identify novel genes involved with these processes in several established model systems. Particular focus will be given to investigating left ventricular wall stress and stretch-dependent gene regulation as controllers of dyadic integrity. Candidate genes will be manipulated in cell models and transgenic animals to promote dyadic formation and maintenance, and reverse dyadic disruption in heart failure. The consequences of dyadic structure for function will be tested experimentally and with mathematical modeling to examine effects on cardiac myocyte calcium homeostasis and whole-heart function. The results of this project are anticipated to yield unprecedented insight into dyadic structure, regulation, and function, and to identify novel therapeutic targets for heart disease patients.
Max ERC Funding
2 000 000 €
Duration
Start date: 2015-07-01, End date: 2020-06-30
Project acronym CRYOSOCIETIES
Project Suspended Life: Exploring Cryopreservation Practices in Contemporary Societies
Researcher (PI) Thomas LEMKE
Host Institution (HI) JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN
Call Details Advanced Grant (AdG), SH3, ERC-2017-ADG
Summary Cryopreservation practices are an essential dimension of contemporary life sciences. They make possible the freezing and storage of cells, tissues and other organic materials at very low temperatures and the subsequent thawing of these at a future date without apparent loss of vitality. Although cryotechnologies are fundamental to reproductive technologies, regenerative medicine, transplantation surgery and conservation biology, they have largely escaped scholarly attention in science and technology studies, anthropology and sociology.
CRYOSOCIETIES explores the crucial role of cryopreservation in affecting temporalities and the concept of life. The project is based on the thesis that in contemporary societies, cryopreservation practices bring into existence a new form of life: “suspended life”. “Suspended life” enables vital processes to be kept in a liminal state in which biological substances are neither fully alive nor dead. CRYOSOCIETIES generates profound empirical knowledge about the creation of “suspended life” through three ethnographic studies that investigate various sites of cryopreservation. A fourth subproject develops a complex theoretical framework in order to grasp the temporal and spatial regimes of the different cryopractices.
CRYOSOCIETIES breaks analytical ground in three important ways. First, the project provides the first systematic and comprehensive empirical study of “suspended life” and deepens our knowledge of how cryopreservation works in different settings. Secondly, it undertakes pioneering work on cryopreservation practices in Europe, generating novel ways of understanding how “suspended life” is assembled, negotiated and mobilised in European societies. Thirdly, CRYOSOCIETIES develops an innovative methodological and theoretical framework in order to address the relationality and materiality of cryopreservation practices and to explore the concept of vitality and the politics of life in the 21st century.
Summary
Cryopreservation practices are an essential dimension of contemporary life sciences. They make possible the freezing and storage of cells, tissues and other organic materials at very low temperatures and the subsequent thawing of these at a future date without apparent loss of vitality. Although cryotechnologies are fundamental to reproductive technologies, regenerative medicine, transplantation surgery and conservation biology, they have largely escaped scholarly attention in science and technology studies, anthropology and sociology.
CRYOSOCIETIES explores the crucial role of cryopreservation in affecting temporalities and the concept of life. The project is based on the thesis that in contemporary societies, cryopreservation practices bring into existence a new form of life: “suspended life”. “Suspended life” enables vital processes to be kept in a liminal state in which biological substances are neither fully alive nor dead. CRYOSOCIETIES generates profound empirical knowledge about the creation of “suspended life” through three ethnographic studies that investigate various sites of cryopreservation. A fourth subproject develops a complex theoretical framework in order to grasp the temporal and spatial regimes of the different cryopractices.
CRYOSOCIETIES breaks analytical ground in three important ways. First, the project provides the first systematic and comprehensive empirical study of “suspended life” and deepens our knowledge of how cryopreservation works in different settings. Secondly, it undertakes pioneering work on cryopreservation practices in Europe, generating novel ways of understanding how “suspended life” is assembled, negotiated and mobilised in European societies. Thirdly, CRYOSOCIETIES develops an innovative methodological and theoretical framework in order to address the relationality and materiality of cryopreservation practices and to explore the concept of vitality and the politics of life in the 21st century.
Max ERC Funding
2 497 587 €
Duration
Start date: 2019-04-01, End date: 2024-03-31
Project acronym DHCP
Project The Developing Human Connectome Project
Researcher (PI) Anthony David Edwards
Host Institution (HI) KING'S COLLEGE LONDON
Call Details Synergy Grants (SyG), SYG6, ERC-2012-SyG
Summary Few advances in neuroscience could have as much impact as a precise global description of human brain connectivity and its variability. Understanding this ‘connectome’ in detail will provide insights into fundamental neural processes and intractable neuropsychiatric diseases.
The connectome can be studied at millimetre scale in humans by neuroimaging, particularly diffusion and functional connectivity Magnetic Resonance Imaging. By linking imaging data to genetic, cognitive and environmental information it will be possible to answer previously unsolvable questions concerning normal mental functioning and intractable neuropsychiatric diseases.
Current human connectome research relates almost exclusively to the mature brain. However mental capacity and neurodevelopmental diseases are created during early development. Advances in fetal and neonatal Magnetic Resonance Imaging now allow us to undertake The Developing Human Connectome Project (dHCP) which will make major scientific progress by: creating the first 4-dimensional connectome of early life; and undertake pioneer studies into normal and abnormal development.
The dHCP will deliver:
• the first dynamic map of human brain connectivity from 20 to 44 weeks post-conceptional age, linked to imaging, clinical, behavioural and genetic information;
• comparative maps of the cerebral connectivity associated with neurodevelopmental abnormality, studying well-characterized patients with either the adverse environmental influence of preterm delivery or genetically-characterised Autistic Spectrum Disorder; and
• novel imaging and analysis methods in an open-source, outward-facing expandable informatics environment that will provide a scalable resource for the research community and advances in clinical medicine.
Summary
Few advances in neuroscience could have as much impact as a precise global description of human brain connectivity and its variability. Understanding this ‘connectome’ in detail will provide insights into fundamental neural processes and intractable neuropsychiatric diseases.
The connectome can be studied at millimetre scale in humans by neuroimaging, particularly diffusion and functional connectivity Magnetic Resonance Imaging. By linking imaging data to genetic, cognitive and environmental information it will be possible to answer previously unsolvable questions concerning normal mental functioning and intractable neuropsychiatric diseases.
Current human connectome research relates almost exclusively to the mature brain. However mental capacity and neurodevelopmental diseases are created during early development. Advances in fetal and neonatal Magnetic Resonance Imaging now allow us to undertake The Developing Human Connectome Project (dHCP) which will make major scientific progress by: creating the first 4-dimensional connectome of early life; and undertake pioneer studies into normal and abnormal development.
The dHCP will deliver:
• the first dynamic map of human brain connectivity from 20 to 44 weeks post-conceptional age, linked to imaging, clinical, behavioural and genetic information;
• comparative maps of the cerebral connectivity associated with neurodevelopmental abnormality, studying well-characterized patients with either the adverse environmental influence of preterm delivery or genetically-characterised Autistic Spectrum Disorder; and
• novel imaging and analysis methods in an open-source, outward-facing expandable informatics environment that will provide a scalable resource for the research community and advances in clinical medicine.
Max ERC Funding
14 974 313 €
Duration
Start date: 2013-09-01, End date: 2019-08-31
Project acronym eEDM
Project A laser-cooled molecular fountain to measure the electron EDM
Researcher (PI) Edward Allen Hinds
Host Institution (HI) IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Call Details Advanced Grant (AdG), PE2, ERC-2012-ADG_20120216
Summary I propose to build an instrument that cools YbF molecules to microK temperature using laser light, and throws them up as a fountain in free fall. This will be used to detect CP-violating elementary particle interactions that caused our universe to evolve an excess of matter over antimatter These interactions cause the charge distribution of the electron to be slightly non-spherical and it is this property, the permanent electric dipole moment (EDM), that the ultracold molecules will sense.
Laser cooling of any molecule is very new, with first results emerging from a few laboratories including mine. Developing a fountain of molecules will be a major advance in the state of the art. As well as being the key to the new EDM instrument, this will be important in its own right because ultracold molecules have major applications in chemistry, quantum information processing and metrology.
In the fountain, the electron spin of each molecule will be polarized. On applying a perpendicular electric field, the spins will precess in proportion to the EDM. At present the (warm) YbF molecules in my lab precess for only 1ms. This gives us world-leading sensitivity, but has not been sufficient to detect the CP-violating forces being sought. The fountain however will achieve precession times of almost a second, giving over 1000x more rotation. The increase in sensitivity should reveal a clear EDM, providing information about the fundamental laws of physics, and the important CP-violating physics of the early universe, which is currently not understood.
By advancing the preparation of ultracold molecules, this project will address a key question in particle physics and cosmology: the nature of CP-violating physics beyond the standard model. The approach is radically different from standard accelerator physics and complements it. The sensitivity is sufficient to detect some proposed new forces that are beyond the reach of any current collider experiment.
Summary
I propose to build an instrument that cools YbF molecules to microK temperature using laser light, and throws them up as a fountain in free fall. This will be used to detect CP-violating elementary particle interactions that caused our universe to evolve an excess of matter over antimatter These interactions cause the charge distribution of the electron to be slightly non-spherical and it is this property, the permanent electric dipole moment (EDM), that the ultracold molecules will sense.
Laser cooling of any molecule is very new, with first results emerging from a few laboratories including mine. Developing a fountain of molecules will be a major advance in the state of the art. As well as being the key to the new EDM instrument, this will be important in its own right because ultracold molecules have major applications in chemistry, quantum information processing and metrology.
In the fountain, the electron spin of each molecule will be polarized. On applying a perpendicular electric field, the spins will precess in proportion to the EDM. At present the (warm) YbF molecules in my lab precess for only 1ms. This gives us world-leading sensitivity, but has not been sufficient to detect the CP-violating forces being sought. The fountain however will achieve precession times of almost a second, giving over 1000x more rotation. The increase in sensitivity should reveal a clear EDM, providing information about the fundamental laws of physics, and the important CP-violating physics of the early universe, which is currently not understood.
By advancing the preparation of ultracold molecules, this project will address a key question in particle physics and cosmology: the nature of CP-violating physics beyond the standard model. The approach is radically different from standard accelerator physics and complements it. The sensitivity is sufficient to detect some proposed new forces that are beyond the reach of any current collider experiment.
Max ERC Funding
2 409 629 €
Duration
Start date: 2013-02-01, End date: 2018-01-31
Project acronym FAB4V
Project A Functional Architecture of the Brain for Vision
Researcher (PI) Edward Hendrik Fokko De Haan
Host Institution (HI) UNIVERSITEIT VAN AMSTERDAM
Call Details Advanced Grant (AdG), SH4, ERC-2013-ADG
Summary We are visual animals. Seeing is our prime means for probing the outside world. Although vision appears effortless, we dedicate about a quarter of our most precious organ to this most prominent of all senses. The primary objective of this research programme is to develop a rigorous new view on how the human brain process visual information. This endeavour is based on two concepts: the methodological issue of necessity and the theoretical framework of cortical networks.
In the last decades, electrophysiological and neuroimaging studies have identified more than 40 separate maps in the brain that are selectively tuned to specific visual features, such colour or motion. Brain-behaviour relationships inferred from electrophysiology and functional neuroimaging are per definition correlational. We need neuropsychological research with patients who suffered focal brain damage to show us which brain structures are necessary. Only structures that, when damaged, have a selective detrimental effect on the execution of that function are necessary. Other structures that are activated during the execution of that function are merely involved in associated processes.
Having established which brain structures are necessary for a specific function, the proposed research programme will investigate how these necessary maps are linked together. As a theoretical perspective, this programme adopts a critical position towards the “what and where pathways” model of Goodale & Milner, the current gold standard. The model postulates two major pathways, each involving a large number of maps; one for processing visuospatial information for motor programming, and one for visual recognition and memory. I have recently suggested an alternative model in which the maps are thought to be organised in multiple overlapping networks. This research programme entails dedicated imaging experiments and a large-scale, neuropsychological study involving four academic medical centres in the Netherlands.
Summary
We are visual animals. Seeing is our prime means for probing the outside world. Although vision appears effortless, we dedicate about a quarter of our most precious organ to this most prominent of all senses. The primary objective of this research programme is to develop a rigorous new view on how the human brain process visual information. This endeavour is based on two concepts: the methodological issue of necessity and the theoretical framework of cortical networks.
In the last decades, electrophysiological and neuroimaging studies have identified more than 40 separate maps in the brain that are selectively tuned to specific visual features, such colour or motion. Brain-behaviour relationships inferred from electrophysiology and functional neuroimaging are per definition correlational. We need neuropsychological research with patients who suffered focal brain damage to show us which brain structures are necessary. Only structures that, when damaged, have a selective detrimental effect on the execution of that function are necessary. Other structures that are activated during the execution of that function are merely involved in associated processes.
Having established which brain structures are necessary for a specific function, the proposed research programme will investigate how these necessary maps are linked together. As a theoretical perspective, this programme adopts a critical position towards the “what and where pathways” model of Goodale & Milner, the current gold standard. The model postulates two major pathways, each involving a large number of maps; one for processing visuospatial information for motor programming, and one for visual recognition and memory. I have recently suggested an alternative model in which the maps are thought to be organised in multiple overlapping networks. This research programme entails dedicated imaging experiments and a large-scale, neuropsychological study involving four academic medical centres in the Netherlands.
Max ERC Funding
2 499 139 €
Duration
Start date: 2014-07-01, End date: 2020-06-30
Project acronym FODEX
Project Tropical Forest Degradation Experiment
Researcher (PI) Edward MITCHARD
Host Institution (HI) THE UNIVERSITY OF EDINBURGH
Call Details Starting Grant (StG), PE10, ERC-2017-STG
Summary We know how to map tropical forest biomass using an array of satellite and aircraft sensors with reasonable accuracy (±15-40 %). However, we do not know how to map biomass change. Simply differencing existing biomass maps produces noisy and biased results, with confidence intervals unknowable using existing static field plots. Thus the potential for using plentiful free satellite data for biomass change mapping is being wasted.
To solve this I propose setting up the first experimental arrays of biomass change plots. In total 52 large plots will be located in logging concessions in Gabon and Peru, where biomass will be assessed before and after logging, and during recovery. In addition to traditional field inventory, terrestrial laser scanning (TLS) data will give the precise 3D shape of thousands of trees before and after disturbance, allowing biomass change to be estimated without bias. The project’s unmanned aerial vehicle (UAV) will collect LiDAR data 4 times over each concession over 4 years, scaling up the field data to give thousands of hectares of biomass change data. In tandem, data from all potentially useful satellites (17+) flying over the field sites over the study period will be ordered and processed.
These data will enable the development of new methods for mapping carbon stock changes, with known uncertainty, which I will scale up across the Amazon basin and west/central Africa. For the first time we will have the methods to assess the balance of regrowth and anthropogenic disturbance across tropical forests, informing us about the status and resilience of the land surface carbon sink. As well as of scientific interest, these results are urgently needed for forest conservation: the Paris Agreement relies on paying countries to reduce losses and enhance gains in forest carbon stocks, but we do not currently have the tools to map forest carbon stock changes. Without accurate monitoring it is not possible to target resources nor assess success.
Summary
We know how to map tropical forest biomass using an array of satellite and aircraft sensors with reasonable accuracy (±15-40 %). However, we do not know how to map biomass change. Simply differencing existing biomass maps produces noisy and biased results, with confidence intervals unknowable using existing static field plots. Thus the potential for using plentiful free satellite data for biomass change mapping is being wasted.
To solve this I propose setting up the first experimental arrays of biomass change plots. In total 52 large plots will be located in logging concessions in Gabon and Peru, where biomass will be assessed before and after logging, and during recovery. In addition to traditional field inventory, terrestrial laser scanning (TLS) data will give the precise 3D shape of thousands of trees before and after disturbance, allowing biomass change to be estimated without bias. The project’s unmanned aerial vehicle (UAV) will collect LiDAR data 4 times over each concession over 4 years, scaling up the field data to give thousands of hectares of biomass change data. In tandem, data from all potentially useful satellites (17+) flying over the field sites over the study period will be ordered and processed.
These data will enable the development of new methods for mapping carbon stock changes, with known uncertainty, which I will scale up across the Amazon basin and west/central Africa. For the first time we will have the methods to assess the balance of regrowth and anthropogenic disturbance across tropical forests, informing us about the status and resilience of the land surface carbon sink. As well as of scientific interest, these results are urgently needed for forest conservation: the Paris Agreement relies on paying countries to reduce losses and enhance gains in forest carbon stocks, but we do not currently have the tools to map forest carbon stock changes. Without accurate monitoring it is not possible to target resources nor assess success.
Max ERC Funding
1 942 471 €
Duration
Start date: 2018-01-01, End date: 2022-12-31
