ERC FUNDED PROJECTS

The brain evolves, develops, and operates in the context of animal movements. As a consequence, fundamental brain functions such as spatial perception and motor control critically depend on the precise knowledge of the ongoing body motion. An accurate internal estimate of self-movement is thought to emerge from sensorimotor integration; nonetheless, which circuits perform this internal estimation, and exactly how motor-sensory coordination is implemented within these circuits are basic questions that remain to be poorly understood. There is growing evidence suggesting that, during locomotion, motor-related and visual signals interact at early stages of visual processing. In mammals, however, it is not clear what the function of this interaction is. Recently, we have shown that a population of Drosophila optic-flow processing neurons —neurons that are sensitive to self-generated visual flow, receives convergent visual and walking-related signals to form a faithful representation of the fly’s walking movements. Leveraging from these results, and combining quantitative analysis of behavior with physiology, optogenetics, and modelling, we propose to investigate circuit mechanisms of self-movement estimation during walking. We will:1) use cell specific manipulations to identify what cells are necessary to generate the motor-related activity in the population of visual neurons, 2) record from the identified neurons and correlate their activity with specific locomotor parameters, and 3) perturb the activity of different cell-types within the identified circuits to test their role in the dynamics of the visual neurons, and on the fly’s walking behavior. These experiments will establish unprecedented causal relationships among neural activity, the formation of an internal representation, and locomotor control. The identified sensorimotor principles will establish a framework that can be tested in other scenarios or animal systems with implications both in health and disease.

1 500 000 €

Start date: 2017-11-01, End date: 2022-10-31

"In a time of accelerating human-caused ecological catastrophe, questions of organizational resilience have become extremely timely. In bringing the archaeological perspective of a 4200-year timespan, ANTHEA seeks to to radically alter our knowledge of resilient forms of self-organisation in past land-use regimes and human-nature entanglements. Based on seven case study areas, ANTHEA will show how collaborative institutions of common land use were organized in the North European heathland regimes (3200 BC-AD 1000), with a particular emphasis on their earliest emergence, their adaption to internal and external factors as well as their ecological, temporal, spatial, and social fabric. More than 4,000 years ago, farming communities across northern Europe began the first fire-based expansion of naturally occurring heather. Pollen evidence suggests that some of these grazing areas, spanning thousands of hectares, existed until the 18th-19th century. Without frequent intervention and management, anthropogenic heathland will turn into forest. So the survival of these areas suggests the existence of highly specialised forms of social organization with the unique capacity to persist. Still, we know little about the actual stability of these heathlands or what caused their unprecedented resilience. By shifting attention away from seeing institutional robustness as equilibrium, stability and continuity and placing the questions of instability, uncertainty, and areal flexibility at the centre, ANTHEA envisages a new cultural history of heathlands that breaks with rooted ideas of these areas being marginal and underdeveloped. ANTHEA is truly multidisciplinary and links landscape and settlement archaeology with paleoenvironmental modelling, social anthropology and philosophy. Moreover, the project introduces a pioneering theoretical and methodological advancement in the temporality of resilience, to be made usable in contemporary land-use policies. The long-term perspective will allow detailed historical trajectories to be established of how common land-use institutions emerged and reorganized according to changing circumstances, challenging the ""tragedy of the commons"" narrative."

1 499 457 €

Start date: 2020-08-01, End date: 2025-07-31

Nanoscale systems binding single molecules, or small numbers of molecules, in conducting junctions show considerable promise for a range of technological applications, from photovoltaics to rectifiers to sensors. These environments differ significantly from the traditional domain of chemical studies involving molecules in solution and the gas phase, necessitating renewed efforts to understand the physical properties of these systems. The objective of this proposal concerns one particular class of physical processes: understanding and controlling local heating in molecular junctions in terms of excitation, dissipation and transfer. Local heating and dissipation in molecular junctions has long been a concern due to the possibly detrimental impact on device stability and function. More recently there has been increased interest, as these processes underlie both spectroscopic techniques and potential technological applications. Together these issues make an investigation of ways to chemically control local heating in molecular junctions timely and important. The proposal objective will be addressed through the investigation of three challenges: - Developing chemical control of local heating in molecular junctions. - Developing chemical control of heat dissipation in molecular junctions. - Design of optimal thermoelectric materials. These three challenges constitute distinct, yet complementary, avenues for investigation with progress in each area supporting the other two. All three challenges build on existing theoretical methods, with the important shift of focus to methods to achieve chemical control. The combination of state-of-the-art computational methods with careful chemical studies promises significant new developments for the area.

1 499 999 €

Start date: 2010-12-01, End date: 2015-11-30

Colonial-Liberation Wars generate plural memories, conflicting evocations and persisting amnesias. The project’s main challenge is to produce innovative knowledge about the memories of the wars fought by the Portuguese state and pro-independence African movements between 1961 and 1974/5. The approach chosen is simultaneously diachronic and comparative, inasmuch as it contrasts changes that took place between the end of the conflicts and nowadays, regarding how wars, colonial pasts and anticolonial legacies have been remembered and silenced in Portugal, Angola, Mozambique, Guinea-Bissau, Cape Verde and São Tomé and Principe. The key hypothesis is that wars - as pivotal moments that ended the cycle of Empire in Portugal and started the cycle of African independences in the former Portuguese colonies - triggered memorialisation and silencing processes which had their own historicity. CROME is divided into two strands. The first one, named ‘Colonial Wars, Postcolonial States’, looks at the role played by the states under consideration in mobilising, articulating and recognising the past, but also in actively generating selective representations. ‘Memory as a battlefield’ is the second strand, which will highlight distinct uses of the past and dynamics between social memories and individual memories. The project intends to demonstrate how wars gave rise to multiple memories and conflicting historical judgements, mostly in Portugal, but also to examine how the specific nature of the (post-)colonial histories of each African country has generated different ways to summon war memories and (anti-)colonial legacies. CROME will, thus, put forward a ground-breaking perspective in terms of colonial-liberation war studies, and will be instrumental in dealing with such traumatic experience, for its comparative approach might help overcoming everlasting constraints still at play today, caused by the historical burden European colonialism left behind.

1 478 249 €

Start date: 2017-02-01, End date: 2023-01-31